AMOA
MCID: ANP008
MIFTS: 30

Anaplastic Oligoastrocytoma (AMOA)

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Anaplastic Oligoastrocytoma

MalaCards integrated aliases for Anaplastic Oligoastrocytoma:

Name: Anaplastic Oligoastrocytoma 52 58 17 71
Amoa 58

Characteristics:

Orphanet epidemiological data:

58
anaplastic oligoastrocytoma
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C0431108
Orphanet 58 ORPHA251663
UMLS 71 C0431108

Summaries for Anaplastic Oligoastrocytoma

NIH Rare Diseases : 52 Anaplastic oligoastrocytoma is a brain tumor that forms when two types of cells in the brain, called oligodendrocytes and astrocytes , rapidly increase in number to form a mass. These brain cells are known as glial cells , which normally protect and support nerve cells in the brain. Because an oligoastrocytoma is made up of a combination of two cell types, it is known as a mixed glioma . An oligoastrocytoma is described as anaplastic when the tumor grows quickly and the cancer cells within the tumor have the potential to spread into surrounding brain tissue or to more distant parts of the body. Oligoastrocytomas usually occur in a part of the brain called the cerebrum and are diagnosed in adults between the ages of 30 and 50. The exact cause of this condition is unknown.

MalaCards based summary : Anaplastic Oligoastrocytoma, also known as amoa, is related to oligoastrocytoma and oligodendroglioma. An important gene associated with Anaplastic Oligoastrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2). The drugs Carmustine and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and myeloid.

Related Diseases for Anaplastic Oligoastrocytoma

Diseases related to Anaplastic Oligoastrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 oligoastrocytoma 10.8
2 oligodendroglioma 10.5
3 glioblastoma multiforme 10.4
4 astrocytoma 10.4
5 anaplastic oligodendroglioma 10.4
6 glioma 10.4
7 glial tumor 10.4
8 grade iii astrocytoma 10.4
9 mixed glioma 10.2
10 3-methylcrotonyl-coa carboxylase 1 deficiency 10.2
11 anoxia 10.2
12 supernumerary breasts 10.2
13 medulloblastoma 10.1
14 mismatch repair cancer syndrome 10.1
15 leukemia, acute myeloid 10.1
16 meningioma, radiation-induced 10.1
17 meningioma, familial 10.1
18 leukemia, acute lymphoblastic 10.1
19 cerebellar medulloblastoma 10.1
20 cysticercosis 10.1
21 lymphocytic leukemia 10.1
22 spinal meningioma 10.1
23 malignant glioma 10.1
24 secretory meningioma 10.1
25 lymphoplasmacyte-rich meningioma 10.1
26 paraplegia 10.1
27 childhood leukemia 10.1
28 myeloid leukemia 10.1
29 opsoclonus-myoclonus syndrome 10.1
30 spastic paraparesis 10.1
31 myoclonus 10.1

Graphical network of the top 20 diseases related to Anaplastic Oligoastrocytoma:



Diseases related to Anaplastic Oligoastrocytoma

Symptoms & Phenotypes for Anaplastic Oligoastrocytoma

Drugs & Therapeutics for Anaplastic Oligoastrocytoma

Drugs for Anaplastic Oligoastrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 3 154-93-8 2578
2
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
3
tannic acid Approved Phase 3 1401-55-4
4
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
5
Histamine Approved, Investigational Phase 3 51-45-6 774
6
Cyproheptadine Approved Phase 3 129-03-3 2913
7 Anesthetics, Local Phase 3
8 Anesthetics Phase 3
9 Central Nervous System Depressants Phase 3
10 Antiviral Agents Phase 3
11 Interferon-alpha Phase 3
12 interferons Phase 3
13 Dermatologic Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Neurotransmitter Agents Phase 3
16 Antipruritics Phase 3
17 Histamine H1 Antagonists Phase 3
18 Serotonin Agents Phase 3
19 Histamine Antagonists Phase 3
20
Histamine Phosphate Phase 3 51-74-1 65513
21 Serotonin Antagonists Phase 3
22 Anti-Allergic Agents Phase 3
23
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
24
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
25
Panobinostat Approved, Investigational Phase 1, Phase 2 404950-80-7 6918837
26
Leflunomide Approved, Investigational Phase 2 75706-12-6 3899
27
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
28
Mannitol Approved, Investigational Phase 2 69-65-8 453 6251
29
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
30
Acetaminophen Approved Phase 2 103-90-2 1983
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
32
Iodine Approved, Investigational Phase 2 7553-56-2 807
33
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
34
Promethazine Approved, Investigational Phase 2 60-87-7 4927
35
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
36
Trioxsalen Approved Phase 2 3902-71-4 5585
37
Vorinostat Approved, Investigational Phase 1, Phase 2 149647-78-9 5311
38 Podophyllotoxin Phase 1, Phase 2 518-28-5
39 Keratolytic Agents Phase 1, Phase 2
40 Antimitotic Agents Phase 1, Phase 2
41 Immunosuppressive Agents Phase 2
42 Antineoplastic Agents, Immunological Phase 2
43 Natriuretic Agents Phase 2
44 diuretics Phase 2
45 Anti-Infective Agents Phase 2
46 Micronutrients Phase 2
47 Trace Elements Phase 2
48 Antibodies, Monoclonal Phase 2
49 BB 1101 Phase 2
50 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study (Phase I Closed) of Radiation Therapy and Temozolomide Versus Radiation Therapy and Nitrosourea for Anaplastic Astrocytoma And Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant) Completed NCT00004259 Phase 3 BCNU 80mg/m2;TMZ 200mg/m2;CCNU;BCNU 150mg/m2;BCNU 200mg/m2;TMZ 150mg/m2 six 6-week cycles;TMZ 150mg/m2 six 8-week cycles
2 A Study on β-elemene as Maintain Treatment for Complete Remission Patients of Newly Diagnosed Malignant Gliomas Following Standard Treatment Recruiting NCT02629757 Phase 3 β-elemene
3 A Phase III Trial on Adjuvant Standard Temozolomide Chemotherapy With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas Recruiting NCT01765088 Phase 3 Temozolomide;α-IFN
4 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Phase I/II Clinical Trial of the Safety, Tolerability, and Anti-tumor Efficacy of the IGF-1R Inhibitor, AXL1717 (Picropodophyllin), in the Treatment of Recurrent Malignant Astrocytomas Unknown status NCT01721577 Phase 1, Phase 2 AXL1717
6 The Efficacy and Safety of Temozolomide in Patients With Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: a Multicenter, Single-arm, Phase II Trial Completed NCT01847235 Phase 2 Temozolomide
7 Phase I/II Study of LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma Completed NCT00859222 Phase 1, Phase 2 LBH589;bevacizumab
8 A Phase II Open Label Study of SU101 for Patients With Anaplastic Astrocytoma in First Relapse Completed NCT00003775 Phase 2 leflunomide
9 Phase II Trial of Bevacizumab Plus Erlotinib for Patients With Recurrent Malignant Glioma Completed NCT00671970 Phase 2 Bevacizumab and Erlotinib
10 Phase II Trial of Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory Glioblastoma Multiforme, Anaplastic Astrocytoma, and Anaplastic Oligoastrocytoma Recruiting NCT02800486 Phase 2 Intra-arterial Cetuximab;Intra-arterial Mannitol
11 Phase I Trial of Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma Recruiting NCT02942264 Phase 1, Phase 2 Zotiraciclib (TG02);TMZ
12 Phase II Study of Intrathecal I-3F8 in Patients With GD2-Expressing Central Nervous System and Leptomeningeal Neoplasms Active, not recruiting NCT00445965 Phase 2
13 A Phase II Study of Temozolomide and O6-Benzylguanine (O6-BG) in Patients With Temozolomide-Resistant Anaplastic Glioma Terminated NCT00389090 Phase 2 Temozolomide and O6-Benzylguanine
14 A Phase II Study of Photodynamic Therapy (PDT) With Photofrin® (IND 104,613) For Recurrent High Grade Gliomas in Adults Terminated NCT01966809 Phase 2 Photofrin photodynamic therapy.
15 Phase I / II Adaptive Randomized Trial of Vorinostat, Erlotinib and Temozolomide in Adults With Recurrent Glioblastoma Multiforme Terminated NCT01110876 Phase 1, Phase 2 Vorinostat;Erlotinib;Temozolomide
16 Phase I/II Trial of Cabazitaxel in Adult Patients With Recurrent Malignant Glioma Withdrawn NCT01740570 Phase 1, Phase 2 Cabazitaxel
17 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
18 A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Toca 511 in Patients With Recurrent High Grade Glioma Completed NCT01156584 Phase 1 Toca FC
19 A Phase 1 Ascending Dose Trial of Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered to Subjects at the Time of Resection for Recurrent High Grade Glioma & Followed by Treatment With Toca FC, Extended-Release 5-FC Completed NCT01470794 Phase 1 Toca FC
20 A Phase 1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered Intravenously Prior to, and Intracranially at the Time of, Subsequent Resection for Recurrent HGG & Followed by Treatment With Extended-Release 5-FC Completed NCT01985256 Phase 1 Toca FC
21 Phase I Dose Finding Study of Sorafenib in Combination With Radiation Therapy and Temozolomide as a First Line Treatment of Patients With High Grade Glioma Completed NCT00884416 Phase 1 Sorafenib dose escalation
22 A Phase I Study of SU011248 Plus Irinotecan in the Treatment of Patients With Malignant Glioma Completed NCT00611728 Phase 1 SU011248 & Irinotecan
23 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
24 A Phase I Trial of the Addition of the Farnesyl Transferase Inhibitor, SCH 66336, to Temodar for Patients With Grade 3 and 4 Malignant Gliomas Completed NCT00612651 Phase 1 Temodar and SCH 66336
25 Phase Ib Study of Oncolytic Polio/Rhinovirus Recombinant Against Recurrent Malignant Glioma in Children Recruiting NCT03043391 Phase 1
26 Phase I Trial of Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme Terminated NCT00671801 Phase 1 Irinotecan;Lenalidomide
27 Imaging After Stereotactic Radiosurgery for Brain Metastases or Primary Tumor Can Hybrid PET-MRI Differentiate Between Radiation Effects and Disease ? Unknown status NCT03068520
28 Diagnostic And Prognostic Markers In High-Grade Glioma Completed NCT01004887
29 Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients and Setting up a Large-scale, Prospective Database for Glioma Patients Treated in UZ Leuven Recruiting NCT03849430

Search NIH Clinical Center for Anaplastic Oligoastrocytoma

Genetic Tests for Anaplastic Oligoastrocytoma

Anatomical Context for Anaplastic Oligoastrocytoma

MalaCards organs/tissues related to Anaplastic Oligoastrocytoma:

40
Brain, Bone, Myeloid, Eye, Spinal Cord, Colon, Testes

Publications for Anaplastic Oligoastrocytoma

Articles related to Anaplastic Oligoastrocytoma:

(show top 50) (show all 1318)
# Title Authors PMID Year
1
Ubiquity, diversity, and activity of comammox Nitrospira in agricultural soils. 61
31862588 2020
2
The conversion of organic nitrogen by functional bacteria determines the end-result of ammonia in compost. 61
31865156 2020
3
Differences in distribution of functional microorganism at DNA and cDNA levels in cow manure composting. 61
31954219 2020
4
Advanced oxygenation efficiency and purification of wastewater using a constant partially unsaturated scheme in column experiments simulating vertical subsurface flow constructed wetlands. 61
31740061 2020
5
Faster nitrogen cycling and more fungal and root biomass in cold ecosystems under experimental warming: a meta-analysis. 61
31750541 2020
6
Seasonal variation of epiphytic bacteria in the phyllosphere of Gingko biloba, Pinus bungeana and Sabina chinensis. 61
32005997 2020
7
Minimizing ammonia emissions from dairy manure composting by biofiltration using a pre-composted material as the packing media. 61
31770691 2020
8
Terrestrial N2 O emissions and related functional genes under climate change: A global meta-analysis. 61
31554024 2020
9
Alteration of soil nitrifiers and denitrifiers and their driving factors during intensive management of Moso bamboo (Phyllostachys pubescens). 61
31841899 2020
10
Microbial indicators are better predictors of wheat yield and quality than N fertilization. 61
31851310 2020
11
Insight into the effects of sulfamethoxazole and norfloxacin on nitrogen transformation functional genes during swine manure composting. 61
31786036 2020
12
Successful enrichment of low-abundant comammox Nitrospira from nitrifying granules under ammonia-limited conditions. 61
32037440 2020
13
Bioremediation by earthworms on soil microbial diversity and partial nitrification processes in oxytetracycline-contaminated soil. 61
31785943 2020
14
Nitrite accumulation in comammox-dominated nitrification-denitrification reactors: Effects of DO concentration and hydroxylamine addition. 61
31629588 2020
15
Differential responses of encoding-amoA nitrifiers and nir denitrifiers in activated sludge to anatase and rutile TiO2 nanoparticles: What is active functional guild in rate limiting step of nitrogen cycle? 61
31668758 2020
16
Source, contribution and microbial N-cycle of N-compounds in China fresh snow. 61
31991341 2020
17
Effects of environmental variables on abundance of ammonia-oxidizing communities in sediments of Luotian River, China. 61
31934502 2020
18
Patients with anteromedial osteoarthritis achieve the greatest improvement in patient reported outcome after total knee arthroplasty. 61
31970507 2020
19
The changes in functional marker genes associated with nitrogen biological transformation during organic-inorganic co-composting. 61
31630888 2020
20
Diversity and abundance of comammox bacteria in the sediments of an urban lake. 61
31989773 2020
21
Ammonia Oxidation Potentials and Ammonia Oxidizers of Lichen-Moss Vegetated Soils at Two Ice-free Areas in East Antarctica. 61
32009017 2020
22
Effects of PVP-coated silver nanoparticles on enzyme activity, bacterial and archaeal community structure and function in a yellow-brown loam soil. 61
31897981 2020
23
A single Thaumarchaeon drives nitrification in deep oligotrophic Lake Constance. 61
31657089 2020
24
Response of ammonia-oxidizing Bacteria and Archaea to long-term saline water irrigation in alluvial grey desert soils. 61
31949227 2020
25
Cold Adapted Nitrosospira sp.: A Potential Crucial Contributor of Ammonia Oxidation in Cryosols of Permafrost-Affected Landscapes in Northeast Siberia. 61
31847402 2019
26
The effect of biochar amendment on N-cycling genes in soils: A meta-analysis. 61
31465924 2019
27
Reduction of N2O emission by biochar and/or 3,4-dimethylpyrazole phosphate (DMPP) is closely linked to soil ammonia oxidizing bacteria and nosZI-N2O reducer populations. 61
31398644 2019
28
Plant rhizosphere, soil microenvironment, and functional genes in the nitrogen removal process of bioretention. 61
31598615 2019
29
The responses of bacterial community and N2O emission to nitrogen input in lake sediment: Estrogen as a co-pollutant. 61
31574450 2019
30
Insight into the nitrification kinetics and microbial response of an enriched nitrifying sludge in the biodegradation of sulfadiazine. 61
31521996 2019
31
Functional relationship between ammonia-oxidizing bacteria and ammonia-oxidizing archaea populations in the secondary treatment system of a full-scale municipal wastewater treatment plant. 61
31787176 2019
32
Toxicity comparison of three imidazolium bromide ionic liquids to soil microorganisms. 61
31610515 2019
33
[Impact of Dicyandiamide (DCD) and 3,4-Dimethylpyrazole Phosphate (DMPP) on Ammonia-oxidizing Bacteria and Archaea in a Vegetable Planting Soil]. 61
31854584 2019
34
Dynamics and underlying mechanisms of N2O and NO emissions in response to a transient land-use conversion of Masson pine forest to tea field. 61
31374503 2019
35
Variable responses of nitrification and denitrification in a paddy soil to long-term biochar amendment and short-term biochar addition. 61
31229717 2019
36
Agricultural management and plant selection interactively affect rhizosphere microbial community structure and nitrogen cycling. 61
31699148 2019
37
Relationship between tillage management and DMPSA nitrification inhibitor efficiency. 61
31848057 2019
38
Genetic associations as indices for assessing nitrogen transformation processes in co-composting of cattle manure and rice straw. 61
31344636 2019
39
Plant-driven niche differentiation of ammonia-oxidizing bacteria and archaea in global drylands. 61
31249390 2019
40
Ammonia Oxidizers in High-Elevation Rivers of the Qinghai-Tibet Plateau Display Distinctive Distribution Patterns. 61
31519662 2019
41
Depth distributions of nitrite reductase (nirK) gene variants reveal spatial dynamics of thaumarchaeal ecotype populations in coastal Monterey Bay. 61
31330081 2019
42
DNA- and RNA-SIP Reveal Nitrospira spp. as Key Drivers of Nitrification in Groundwater-Fed Biofilters. 61
31690672 2019
43
Long-term N fertilization imbalances potential N acquisition and transformations by soil microbes. 61
31325856 2019
44
Abundance and community composition of comammox bacteria in different ecosystems by a universal primer set. 61
31319252 2019
45
Effects of combined biochar and organic fertilizer on nitrous oxide fluxes and the related nitrifier and denitrifier communities in a saline-alkali soil. 61
31176819 2019
46
Nonylphenol causes shifts in microbial communities and nitrogen mineralization in soil microcosms. 61
31212188 2019
47
Fast start-up strategies of MBBR for mariculture wastewater treatment. 61
31325791 2019
48
Isolation and identification of a salt-tolerant aerobic denitrifying bacterial strain and its application to saline wastewater treatment in constructed wetlands. 61
31301568 2019
49
Ecological Success of the Nitrosopumilus and Nitrosospira Clusters in the Intertidal Zone. 61
30903203 2019
50
Molecular and isotopic evidence of the distribution of nitrogen-cycling microbial communities in the oxygen minimum zone of the Tropical Mexican Pacific. 61
31557275 2019

Variations for Anaplastic Oligoastrocytoma

Expression for Anaplastic Oligoastrocytoma

Search GEO for disease gene expression data for Anaplastic Oligoastrocytoma.

Pathways for Anaplastic Oligoastrocytoma

GO Terms for Anaplastic Oligoastrocytoma

Sources for Anaplastic Oligoastrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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32 ICD10
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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70 Tocris
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