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MCID: ANP009
MIFTS: 43

Anaplastic Oligodendroglioma

Categories: Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anaplastic Oligodendroglioma

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MalaCards integrated aliases for Anaplastic Oligodendroglioma:

Name: Anaplastic Oligodendroglioma 52 58 54 17 71
Oligodendroglioma, Anaplastic 6

Characteristics:

Orphanet epidemiological data:

58
anaplastic oligodendroglioma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C0334590
Orphanet 58 ORPHA251630
UMLS 71 C0334590
Sources

Summaries for Anaplastic Oligodendroglioma

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NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 251630 Definition A rare glial tumor characterized by a grade III oligodendroglial tumour with focal or diffuse anaplastic features. It typically occurs in the supratentorial white matter. Histologically, the cells are enlarged and epithelioid with pleomorphic and increased size nuclei, a vesicular chromatin pattern and prominent nucleoli. Most patients present with seizures . Visit the Orphanet disease page for more resources.

MalaCards based summary : Anaplastic Oligodendroglioma, also known as oligodendroglioma, anaplastic, is related to oligoastrocytoma and glioma, and has symptoms including seizures and headache. An important gene associated with Anaplastic Oligodendroglioma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are DNA Damage and Neural Crest Differentiation. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Anaplastic Oligodendroglioma

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Diseases related to Anaplastic Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 oligoastrocytoma 31.1 MGMT IDH2
2 glioma 30.6 POT1 IDH2 CDKN2A
3 juvenile pilocytic astrocytoma 30.1 OLIG2 MGMT
4 spinal cord oligodendroglioma 30.1 MGMT IDH2
5 mixed glioma 30.0 OLIG2 MGMT IDH2
6 brain glioma 29.8 MGMT IDH2
7 brain cancer 29.5 OLIG2 OLIG1 MGMT IDH2
8 glioma susceptibility 1 29.4 OLIG2 MGMT IDH2 CDKN2A
9 meningioma, familial 29.3 OLIG2 MGMT CDKN2A
10 grade iii astrocytoma 29.0 OLIG2 OLIG1 MGMT IDH2 CDKN2A
11 oligodendroglioma 28.6 POT1 OLIG2 OLIG1 MGMT IDH2 CDKN2C
12 glioblastoma multiforme 10.6
13 glial tumor 10.6
14 anaplastic oligoastrocytoma 10.5
15 astrocytoma 10.5
16 malignant glioma 10.4
17 arteriovenous malformation 10.2
18 parkinson disease, late-onset 10.1
19 leukemia, acute lymphoblastic 10.1
20 lymphocytic leukemia 10.1
21 hydrocephalus 10.1
22 central neurocytoma 10.1
23 gangliocytoma 10.1
24 ganglioglioma 10.1
25 back pain 10.1
26 rare surgical neurologic disease 10.1
27 adult oligodendroglioma 10.1 OLIG2 IDH2
28 adult brain stem glioma 10.1 MGMT IDH2
29 central nervous system rhabdomyosarcoma 10.1 MGMT IDH2
30 gemistocytic astrocytoma 10.0 MGMT IDH2
31 adult astrocytic tumour 10.0 IDH2 CDKN2A
32 central nervous system benign neoplasm 10.0 OLIG2 IDH2
33 cerebral cavernous malformations 10.0
34 endosteal hyperostosis, autosomal dominant 10.0
35 li-fraumeni syndrome 10.0
36 williams-beuren syndrome 10.0
37 lymphoma, hodgkin, classic 10.0
38 myeloma, multiple 10.0
39 lymphoma, non-hodgkin, familial 10.0
40 meningioma, radiation-induced 10.0
41 psoriatic arthritis 10.0
42 li-fraumeni syndrome 2 10.0
43 lymphoma 10.0
44 childhood acute lymphocytic leukemia 10.0
45 lymphoblastic lymphoma 10.0
46 hepatic veno-occlusive disease 10.0
47 disseminated intravascular coagulation 10.0
48 pneumocystosis 10.0
49 spinal meningioma 10.0
50 neutropenia 10.0

Graphical network of the top 20 diseases related to Anaplastic Oligodendroglioma:



Diseases related to Anaplastic Oligodendroglioma
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Symptoms & Phenotypes for Anaplastic Oligodendroglioma

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UMLS symptoms related to Anaplastic Oligodendroglioma:


seizures, headache

GenomeRNAi Phenotypes related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.4 CDKN2A CDKN2C POT1
2 Decreased viability GR00221-A-3 9.4 CDKN2A POT1
3 Decreased viability GR00221-A-4 9.4 CDKN2A POT1
4 Decreased viability GR00301-A 9.4 CDKN2C
5 Decreased viability GR00342-S-2 9.4 CDKN2C
6 Decreased viability GR00402-S-2 9.4 CDKN2A CDKN2C POT1

MGI Mouse Phenotypes related to Anaplastic Oligodendroglioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.55 CDKN2A CDKN2C IDH2 MGMT OLIG2
2 no phenotypic analysis MP:0003012 9.26 CDKN2A MGMT OLIG2 POT1
3 respiratory system MP:0005388 8.92 CDKN2A CDKN2C MGMT OLIG2
Sources

Drugs & Therapeutics for Anaplastic Oligodendroglioma

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Drugs for Anaplastic Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 283)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3
Lomustine Approved, Investigational Phase 3 13010-47-4 3950
4
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
5
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
6
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
7
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
11 Anesthetics Phase 3
12 Analgesics Phase 3
13 Central Nervous System Depressants Phase 3
14 Nootropic Agents Phase 3
15 Cholinergic Agents Phase 3
16 Cholinesterase Inhibitors Phase 3
17 Liver Extracts Phase 3
18 Cola Phase 3
19 Narcotics Phase 3
20 Anesthetics, General Phase 3
21 Analgesics, Opioid Phase 3
22 Adjuvants, Anesthesia Phase 3
23 Anesthetics, Intravenous Phase 3
24 Antimitotic Agents Phase 3
25 Alkylating Agents Phase 3
26 Gastrointestinal Agents Phase 3
27 Neurotransmitter Agents Phase 3
28 Dopamine Uptake Inhibitors Phase 3
29 Central Nervous System Stimulants Phase 3
30 Dexmethylphenidate Hydrochloride Phase 3
31 Dopamine Agents Phase 3
32 Antipruritics Phase 3
33 Histamine H1 Antagonists Phase 3
34 Serotonin Agents Phase 3
35 Histamine Antagonists Phase 3
36
Histamine Phosphate Phase 3 51-74-1 65513
37 Serotonin Antagonists Phase 3
38 Anti-Allergic Agents Phase 3
39
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
40
Ethanol Approved Phase 1, Phase 2 64-17-5 702
41
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
42
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
43
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
44
Bevacizumab Approved, Investigational Phase 2 216974-75-3
45
Oxcarbazepine Approved Phase 1, Phase 2 28721-07-5 34312
46
Phenobarbital Approved, Investigational Phase 1, Phase 2 50-06-6 4763
47
Phenytoin Approved, Vet_approved Phase 1, Phase 2 57-41-0 1775
48
Carbamazepine Approved, Investigational Phase 1, Phase 2 298-46-4 2554
49
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
50
Primidone Approved, Vet_approved Phase 1, Phase 2 125-33-7 4909

Interventional clinical trials:

(show top 50) (show all 171)
# Name Status NCT ID Phase Drugs
1 PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA Completed NCT00002840 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
2 Phase III Intergroup Randomized Comparison of Radiation Alone vs. Pre-Radiation Chemotherapy for Pure and Mixed Anaplastic Oligodendrogliomas Completed NCT00002569 Phase 3 lomustine;procarbazine hydrochloride;vincristine sulfate
3 Phase III Double Blind, Placebo Controlled Study of Donepezil in the Irradiated Brain Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
5 Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma Recruiting NCT00887146 Phase 3 concomitant temozolomide (TMZ);procarbazine;adjuvant temozolomide (TMZ);CCNU;vincristine
6 Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial. Active, not recruiting NCT00626990 Phase 3 temozolomide
7 A Phase III, Double-Blind, Prospective Randomized Clinical Trial of the Effect of D-threo-methylphenidate HCl (d-MPH) on Quality of Life in Brain Tumor Patients Receiving Radiation Therapy Terminated NCT00031798 Phase 3 methylphenidate hydrochloride
8 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
9 Phase III Randomized Evaluation of 13-Cis-Retinoic Acid (cRA) Plus Procarbazine Versus Procarbazine Alone in the Treatment of Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
10 Phase I/II Clinical Trial of the Safety, Tolerability, and Anti-tumor Efficacy of the IGF-1R Inhibitor, AXL1717 (Picropodophyllin), in the Treatment of Recurrent Malignant Astrocytomas Unknown status NCT01721577 Phase 1, Phase 2 AXL1717
11 A Phase II Study of Temozolomide in the Treatment of Recurrent Malignant Gliomas Unknown status NCT00004204 Phase 2 temozolomide
12 Phase I/II Study of Intratumoral Injection of DTI-015 Prior to Tumor Resection in Patients With Recurrent Malignant Glioma or Metastatic Neoplasm to Brain Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
13 Pilot Study to Determine Therapeutic Response of Oral Capecitabine (Xeloda) in Recurrent High Grade Gliomas (HGGs) by Establishing the Radiographic Response Rate Using Modified Macdonald Criteria Completed NCT00717197 Phase 2 Capecitabine
14 Phase II Trial of Bevacizumab Plus Erlotinib for Patients With Recurrent Malignant Glioma Completed NCT00671970 Phase 2 Bevacizumab and Erlotinib
15 Phase II Treatment of Adults With Newly Diagnosed, Progressive or Recurrent Primary Malignant Anaplastic Oligodendroglioma With Temodal Completed NCT00003465 Phase 2 temozolomide
16 The Efficacy and Safety of Temozolomide in Patients With Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: a Multicenter, Single-arm, Phase II Trial Completed NCT01847235 Phase 2 Temozolomide
17 Phase II Trial of Continuous Dose Temozolomide in Patients With Newly Diagnosed Pure and Mixed Anaplastic Oligodendroglioma Completed NCT00400816 Phase 2 temozolomide
18 Open Label Phase II Study On STI571 (Glivec) Administered As A Daily Oral Treatment In Gliomas Completed NCT00039364 Phase 2 imatinib mesylate
19 A Phase II Study of Topotecan in Patients With Anaplastic Oligodendroglioma or Anaplastic Mixed Oligoastrocytoma Completed NCT00003372 Phase 2 topotecan hydrochloride
20 Phase II Evaluation of Fenretinide NSC (374551) as a Single Agent in the Treatment of Adult Patients With Recurrent Malignant Glioma Completed NCT00006080 Phase 2 fenretinide
21 Phase II Trial of Continuous Dose Temozolomide in Patients With Newly Diagnosed Anaplastic Oligodendroglioma and Mixed Oligoastrocytoma Completed NCT00362570 Phase 2 Temozolomide
22 Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms Completed NCT00004688 Phase 2 carmustine;mercaptopurine;streptozocin
23 A Phase I/II Trial Of MGI114 For Treatment Of Patients With Recurrent Malignant Gliomas Completed NCT00012038 Phase 1, Phase 2 irofulven
24 A Phase I/II Study of Col-3 Administered on a Continuous Daily Oral Schedule in Patients With Recurrent High-Grade Astrocytoma Completed NCT00004147 Phase 1, Phase 2 incyclinide
25 A Phase II Trial of Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma Completed NCT00003101 Phase 2 busulfan;lomustine;procarbazine hydrochloride;thiotepa;vincristine sulfate
26 A Phase II Trial of Continuous Low-Dose Temozolomide for Patients With Recurrent Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
27 Bevacizumab in Combination With Irinotecan for Malignant Gliomas Completed NCT00268359 Phase 2 irinotecan hydrochloride
28 A Phase II Trial of Poly ICLC in Patients With Recurrent Anaplastic Glioma Completed NCT00058123 Phase 2 poly ICLC
29 A Phase II Study of Temozolomide (SCH 52365, Temodal(R)) for the Treatment of Recurrent Malignant Glioma Completed NCT00004113 Phase 2 temozolomide
30 A Multi-Center, Open-Label Clinical Study to Evaluate the Safety and Performance of the Proxima GliaSite RTS, a Radiation Delivery System, in Patients With Recurrent Malignant Brain Tumors Undergoing Surgical Resection Completed NCT00003574 Phase 2
31 ANALYSIS OF THE EFFICACY OF SURAMIN IN RECURRENT MALIGNANT PRIMARY BRAIN TUMORS Completed NCT00002639 Phase 2 chemotherapy;suramin
32 Phase I/II Study of LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma Completed NCT00859222 Phase 1, Phase 2 LBH589;bevacizumab
33 Improved Characterization of Brain Tumors By MRI and MRS Completed NCT00274755 Phase 2 chemotherapy
34 A Phase II Trial Of Talampanel In Patients With Recurrent High-Grade Gliomas Completed NCT00064363 Phase 2 talampanel
35 Phase I/II Trial of Imatinib Mesylate; (Gleevec; STI571) in Treatment of Recurrent Oligodendroglioma and Mixed Oligoastrocytoma Completed NCT00049127 Phase 1, Phase 2 Imatinib Mesylate
36 Trial Of Oral Thalidomide, Celecoxib, Etoposide And Cyclophosphamide In Adult Patients With Relapsed Or Progressive Malignant Gliomas Completed NCT00047281 Phase 2 celecoxib;cyclophosphamide;etoposide;thalidomide
37 A Phase II Trial Of Pre-Irradiation And Concurrent Temozolomide In Patients With Newly Diagnosed Anaplastic Oligodendrogliomas And Mixed Anaplastic Oligoastrocytomas Completed NCT00033280 Phase 2 temozolomide
38 A Phase II Trial Of Thalidomide And Procarbazine In Adults With Recurrent/Progressive Gliomas Completed NCT00079092 Phase 2 procarbazine hydrochloride;thalidomide
39 A Phase I/II Trial of EMD 121974 for Treatment of Patients With Recurrent Anaplastic Gliomas Completed NCT00006093 Phase 1, Phase 2 cilengitide
40 A Phase I/II Study of Oral Procarbazine in the Treatment of Recurrent High Grade Astrocytomas Completed NCT00004004 Phase 1, Phase 2 procarbazine hydrochloride
41 Phase II Study of Antineoplastons A10 and AS2-1 in Children With Brain Tumors Completed NCT00003458 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
42 PHASE I STUDY OF ANTI-TENASCIN MONOCLONAL ANTIBODY 131I 81C6 VIA SURGICALLY CREATED CYSTIC RESECTION CAVITY IN THE TREATMENT OF PATIENTS WITH PRIMARY OR METASTATIC MALIGNANT BRAIN TUMORS Completed NCT00002752 Phase 1, Phase 2
43 Levetiracetam and Pregabalin for Monotherapy in Patients With Brain Tumors and Seizures. A Phase II Randomized Study. Completed NCT00629889 Phase 2 levetiracetam;pregabalin
44 A Phase 2, Open-label, Proof-of-concept Study to Assess the Ability to Detect Tumours and Angiogenesis Via the Expression of ανβ3/5 Integrin Receptors by [18F]AH-111585 PET Imaging Completed NCT00565721 Phase 2 Fluciclatide Injection - (AH111585 (F18))
45 A Pilot Study of Tamoxifen, Carboplatin and Topotecan in the Treatment of Recurrent or Refractory Primary Brain or Spinal Cord Tumors or Metastatic Epithelial Cancers With Central Nervous System Metastases Completed NCT00541138 Phase 2 carboplatin;tamoxifen citrate;topotecan hydrochloride
46 Phase II Study of Bevacizumab (Avastin) and BCNU for Treatment of Relapsed, High Grade Gliomas Completed NCT00795665 Phase 2 bevacizumab;carmustine
47 Donepezil and EGb761 in Improving Neurocognitive Function in Patients Who Have Previously Undergone Radiation Therapy for Primary Brain Tumor or Brain Metastases Completed NCT00070161 Phase 2 donepezil hydrochloride
48 ZD1839 FOR Treatment Of Recurrent Or Progressive Malignant Astrocytoma Or Glioblastoma And Recurrent Or Progressive Meningioma: A Phase II Study With A Phase I Component For Patients Receiving EIAEDs Completed NCT00025675 Phase 2 gefitinib
49 Phase I/II Trial Of CCI-779 In Patients With Malignant Glioma Completed NCT00022724 Phase 1, Phase 2 temsirolimus
50 CAMP 004A - Phase 2 Study Of Intensive Chemotherapy (BET) For Selected Categories Of Malignant Central Nervous System Tumor Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa

Search NIH Clinical Center for Anaplastic Oligodendroglioma

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Genetic Tests for Anaplastic Oligodendroglioma

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Anatomical Context for Anaplastic Oligodendroglioma

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MalaCards organs/tissues related to Anaplastic Oligodendroglioma:

40
Brain, Spinal Cord, Bone, T Cells, Breast, Bone Marrow, B Cells
Sources

Publications for Anaplastic Oligodendroglioma

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Articles related to Anaplastic Oligodendroglioma:

(show top 50) (show all 571)
# Title Authors PMID Year
1
IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas. 54 61
19805356 2009
2
[Temozolomide: Temodal]. 54 61
18347414 2008
3
Serum GFAP is a diagnostic marker for glioblastoma multiforme. 54 61
17998256 2007
4
The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. 54 61
17440165 2007
5
Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: a clinicopathological study using fluorescence in situ hybridization. 54 61
17319279 2007
6
[Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors]. 54 61
17236582 2006
7
Malignant glioma: neuropathology and neurobiology. 54 61
16944363 2006
8
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. 54 61
15455350 2005
9
PTEN is a target of chromosome 10q loss in anaplastic oligodendrogliomas and PTEN alterations are associated with poor prognosis. 54 61
11438483 2001
10
Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas. 54 61
11307615 2001
11
Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors. 54 61
10515227 1999
12
Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: a revelation by parallel gene expression profiling. 54 61
10485462 1999
13
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. 54 61
9776413 1998
14
Epidermal growth factor receptor expression in oligodendroglial tumors. 54 61
8686753 1996
15
Lectins: reliable differentiation markers in human oligodendrogliomas. 54 61
8220777 1993
16
Spinal leptomeningeal oligodendrogliomatosis after resection of cerebral anaplastic oligodendoglioma with 1p19q Co-deletion - A case report. 61
32007374 2020
17
Pattern of failure in anaplastic glioma patients with an IDH1/2 mutation. 61
31028406 2020
18
Prognostic Value of O-(2-[18F]Fluoroethyl)-L-Tyrosine PET/CT in Newly Diagnosed WHO 2016 Grade II and III Glioma. 61
30977078 2019
19
High-grade Glioma Masquerading as a Small Cerebral Hemorrhage: A Case Report. 61
31849570 2019
20
Experience Profiling of Fluorescence-Guided Surgery I: Gliomas. 61
31686440 2019
21
The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade III Cerebral Gliomas in Adults: Version 2019.01. 61
31686436 2019
22
Anaplastic Oligodendroglioma with Transdural Extension. 61
31254692 2019
23
Extent of resection and survival for oligodendroglioma: a U.S. population-based study. 61
31407129 2019
24
Ki-67 and MCM6 labeling indices are correlated with overall survival in anaplastic oligodendroglioma, IDH1-mutant and 1p/19q-codeleted: a multicenter study from the French POLA network. 61
31561286 2019
25
Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification. 61
31370384 2019
26
A novel PTPRZ1-ETV1 fusion in gliomas. 61
31381204 2019
27
Scalp Metastasis of Anaplastic Oligodendroglioma. 61
31125773 2019
28
Anaplastic oligodendroglioma metastasizing to the bone marrow: a unique case report and literature review. 61
30526175 2019
29
[IDH、TERT and 1p/19q predicting clinical outcomes in patients with anaplastic oligodendroglioma]. 61
31269600 2019
30
PI3K/AKT/mTOR Pathway Alterations Promote Malignant Progression and Xenograft Formation in Oligodendroglial Tumors. 61
30975663 2019
31
Potential influence of IDH1 mutation and MGMT gene promoter methylation on glioma-related preoperative seizures and postoperative seizure control. 61
31141785 2019
32
Incidence trends of adult malignant brain tumors in Finland, 1990-2016. 61
30985227 2019
33
c-Met Expression Is a Useful Marker for Prognosis Prediction in IDH-Mutant Lower-Grade Gliomas and IDH-Wildtype Glioblastomas. 61
30878754 2019
34
Bone metastases from a 1p/19q codeleted and IDH1-mutant anaplastic oligodendroglioma: a case report. 61
31248444 2019
35
Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management. 61
30677248 2019
36
Glioma Tumor Grade Identification Using Artificial Intelligent Techniques. 61
30900029 2019
37
Anaplastic Oligodendroglioma Found as an Incidental Photopenic Lesion on 18F-FP-CIT PET/CT Image. 61
30672761 2019
38
Sequencing of Chemotherapy and Radiotherapy for Newly Diagnosed Anaplastic Oligodendroglioma and Oligoastrocytoma. 61
30601146 2019
39
Determination of genetic aberrations and novel transcripts involved in the pathogenesis of oligodendroglioma using array comparative genomic hybridization and next generation sequencing. 61
30675227 2019
40
Navigated Transcranial Magnetic Stimulation in Patient with Cranioplasty in Situ: Safe and Accurate Procedure. 61
30296623 2019
41
Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: a case report and review of current challenges in molecular diagnostics. 61
30738431 2019
42
Radiomics-Based Machine Learning Technology Enables Better Differentiation Between Glioblastoma and Anaplastic Oligodendroglioma. 61
31750250 2019
43
Glioma Simultaneously Present with Adjacent Meningioma: Case Report and Literature Review. 61
30937052 2019
44
Ability of Radiomics in Differentiation of Anaplastic Oligodendroglioma From Atypical Low-Grade Oligodendroglioma Using Machine-Learning Approach. 61
31921635 2019
45
Neuro-Oncology Clinical Debate: PCV or temozolomide in combination with radiation for newly diagnosed high-grade oligodendroglioma. 61
31386006 2019
46
Prognostic factors associated with survival in patients with anaplastic oligodendroglioma. 61
30699183 2019
47
Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma. 61
30446361 2019
48
Clinical and Molecular Recursive Partitioning Analysis of High-grade Glioma Treated With IMRT. 61
29912004 2019
49
Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma. 61
30018130 2018
50
Tumour-to-Tumour Metastasis Phenomenon: Metastatic Prostatic Adenocarcinoma within an Anaplastic Oligodendroglioma in the Brain of a Dog. 61
30502799 2018
Sources

Variations for Anaplastic Oligodendroglioma

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ClinVar genetic disease variations for Anaplastic Oligodendroglioma:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CIC NM_015125.4(CIC):c.643C>T (p.Arg215Trp)SNV Likely pathogenic 635170 rs1568504941 19:42791757-42791757 19:42287605-42287605
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Expression for Anaplastic Oligodendroglioma

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Search GEO for disease gene expression data for Anaplastic Oligodendroglioma.
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Pathways for Anaplastic Oligodendroglioma

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Pathways related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
DNA Damage 4
11.6 MGMT CDKN2C CDKN2A
2
Neural Crest Differentiation 1
11.27 OLIG2 OLIG1
3
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.05 OLIG2 OLIG1
4
Oncogene Induced Senescence 65
10.13 CDKN2C CDKN2A
Sources

GO Terms for Anaplastic Oligodendroglioma

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Biological processes related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G1/S transition of mitotic cell cycle GO:0000082 9.37 CDKN2C CDKN2A
2 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.32 CDKN2C CDKN2A
3 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 CDKN2C CDKN2A
4 neuron fate commitment GO:0048663 9.16 OLIG2 OLIG1
5 negative regulation of phosphorylation GO:0042326 8.96 CDKN2C CDKN2A
6 oligodendrocyte differentiation GO:0048709 8.8 OLIG2 OLIG1 CDKN2C

Molecular functions related to Anaplastic Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.35 POT1 OLIG2 OLIG1 MGMT CDKN2A
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.62 CDKN2C CDKN2A
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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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