MCID: ANP032
MIFTS: 16

Anaplastic Pleomorphic Xanthoastrocytoma

Categories: Rare diseases

Aliases & Classifications for Anaplastic Pleomorphic Xanthoastrocytoma

MalaCards integrated aliases for Anaplastic Pleomorphic Xanthoastrocytoma:

Name: Anaplastic Pleomorphic Xanthoastrocytoma 53

Classifications:



Summaries for Anaplastic Pleomorphic Xanthoastrocytoma

MalaCards based summary : Anaplastic Pleomorphic Xanthoastrocytoma is related to pleomorphic xanthoastrocytoma and glioblastoma multiforme. An important gene associated with Anaplastic Pleomorphic Xanthoastrocytoma is TP53 (Tumor Protein P53). The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cerebellum.

Related Diseases for Anaplastic Pleomorphic Xanthoastrocytoma

Diseases related to Anaplastic Pleomorphic Xanthoastrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 11.0
2 glioblastoma multiforme 10.6
3 glioblastoma 10.6
4 astrocytoma 10.4
5 rare tumor 10.4
6 neurofibromatosis, type iv, of riccardi 10.2
7 retinoblastoma 10.2
8 aphasia 10.2
9 malignant glioma 10.2
10 giant cell glioblastoma 10.2
11 grade iii astrocytoma 10.2
12 familial retinoblastoma 10.2
13 benign ependymoma 10.2
14 ganglioglioma 10.2
15 astroblastoma 10.2
16 neurofibroma 10.2
17 anaplastic ganglioglioma 10.2
18 ependymoma 10.2
19 glioma 10.2
20 glial tumor 10.2
21 high-grade astrocytoma 10.2

Graphical network of the top 20 diseases related to Anaplastic Pleomorphic Xanthoastrocytoma:



Diseases related to Anaplastic Pleomorphic Xanthoastrocytoma

Symptoms & Phenotypes for Anaplastic Pleomorphic Xanthoastrocytoma

Drugs & Therapeutics for Anaplastic Pleomorphic Xanthoastrocytoma

Drugs for Anaplastic Pleomorphic Xanthoastrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trametinib Approved Phase 2 871700-17-3 11707110
2
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
3
Dimethyl sulfoxide Approved, Vet_approved Phase 2 67-68-5 679
4 Free Radical Scavengers Phase 2
5 Antioxidants Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Protective Agents Phase 2
8
Gemcitabine Approved Phase 1 95058-81-4 60750
9
Lenograstim Approved, Investigational Phase 1 135968-09-1
10 Anesthetics Phase 1
11 Vaccines Phase 1
12 Adjuvants, Immunologic Phase 1
13 Anti-Infective Agents Phase 1
14 Immunosuppressive Agents Phase 1
15 Immunologic Factors Phase 1
16 Antimetabolites Phase 1
17 Antiviral Agents Phase 1
18 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Dabrafenib (NSC# 763760) With Trametinib (NSC# 763093) After Local Irradiation in Newly-Diagnosed BRAF V600-Mutant High-Grade Glioma (HGG) Not yet recruiting NCT03919071 Phase 2 Dabrafenib;Dabrafenib Mesylate;Trametinib;Trametinib Dimethyl Sulfoxide
2 A Phase II Study of Binimetinib in Combination With Encorafenib in Adults With Recurrent BRAF V600-Mutated High-Grade Astrocytoma or Other Primary Brain Tumor Not yet recruiting NCT03973918 Phase 2 Encorafenib;Binimetinib
3 Phase Ib Study of Oncolytic Polio/Rhinovirus Recombinant Against Recurrent Malignant Glioma in Children Recruiting NCT03043391 Phase 1
4 Molecularly-Driven Doublet Therapy for All Children With Refractory or Recurrent CNS Malignant Neoplasms and Young Adults With Refractory or Recurrent SHH Medulloblastoma Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib

Search NIH Clinical Center for Anaplastic Pleomorphic Xanthoastrocytoma

Genetic Tests for Anaplastic Pleomorphic Xanthoastrocytoma

Anatomical Context for Anaplastic Pleomorphic Xanthoastrocytoma

MalaCards organs/tissues related to Anaplastic Pleomorphic Xanthoastrocytoma:

41
Brain, Testes, Cerebellum

Publications for Anaplastic Pleomorphic Xanthoastrocytoma

Articles related to Anaplastic Pleomorphic Xanthoastrocytoma:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Evaluation of EZH2 expression, BRAF V600E mutation, and CDKN2A/B deletions in epithelioid glioblastoma and anaplastic pleomorphic xanthoastrocytoma. 38
31214915 2019
2
Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors. 38
31435824 2019
3
Histological and genetic analysis of anaplastic pleomorphic xanthoastrocytoma suspected of malignant progression over a 12-year clinical course. 38
31397529 2019
4
Anaplastic pleomorphic xanthoastrocytoma associated with an H3G34 mutation: a case report with review of literature. 38
31350684 2019
5
Retinal anaplastic pleomorphic xanthoastrocytoma unassociated with phakomatosis. 38
31317107 2019
6
Urothelial carcinoma with an NRF1-BRAF rearrangement and response to targeted therapy. 38
31010895 2019
7
A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorously-case report and review of the literature. 38
30182181 2019
8
BRAF V600E-mutated central nervous system tumor with divergent morphological feature - Anaplastic pleomorphic xanthoastrocytoma-like and astroblastoma-like. 38
30557911 2019
9
Genome-wide DNA methylation profiling shows molecular heterogeneity of anaplastic pleomorphic xanthoastrocytoma. 38
30609203 2019
10
The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. 38
30051528 2019
11
Anaplastic pleomorphic xanthoastrocytoma with leptomeningeal dissemination responsive to BRAF inhibition and bevacizumab. 38
30255633 2019
12
Role of a Promoter Mutation in TERT in Malignant Transformation of Pleomorphic Xanthoastrocytoma. 38
30599247 2018
13
BRAF V600E, TERT, and IDH2 Mutations in Pleomorphic Xanthoastrocytoma: Observations from a Large Case-Series Study. 38
30240866 2018
14
Complete Remission of an Extracranially Disseminated Anaplastic Pleomorphic Xanthoastrocytoma With Everolimus: A Case Report and Literature Review. 38
30322731 2018
15
Clinico-Histomorphological and Immunohistochemical Profile of Anaplastic Pleomorphic Xanthoastrocytoma: Report of Five Cases and Review of Literature. 38
30774826 2018
16
Response to BRAF/MEK Inhibition After Progression With BRAF Inhibition in a Patient With Anaplastic Pleomorphic Xanthoastrocytoma. 38
30169370 2018
17
Sustained Response to Targeted Therapy in a Patient With Disseminated Anaplastic Pleomorphic Xanthoastrocytoma. 38
29200156 2018
18
MR Imaging Features of Anaplastic Pleomorphic Xanthoastrocytoma Mimicking High-Grade Astrocytoma. 38
29903923 2018
19
Intraventricular Anaplastic Pleomorphic Xanthoastrocytoma: Very Rare Localization and Early Recurrence of a Rare Tumor. 38
30042916 2018
20
Concurrent BRAF/MEK Inhibitors in BRAF V600-Mutant High-Grade Primary Brain Tumors. 38
29632053 2018
21
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. 38
28960623 2018
22
BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma. 38
29544532 2018
23
Recurrent copy number alterations in low-grade and anaplastic pleomorphic xanthoastrocytoma with and without BRAF V600E mutation. 38
28181325 2018
24
WHO 2016 Classification of gliomas. 38
28815663 2018
25
Anaplastic Pleomorphic Xanthoastrocytoma Presenting with Musical Hallucination. 38
30534452 2018
26
[The 2016 WHO classification of primary central nervous system tumors: a clinician's view]. 38
29927430 2018
27
Ganglioglioma Progression to Combined Anaplastic Ganglioglioma and Anaplastic Pleomorphic Xanthoastrocytoma. Case Report and Literature Review. 38
28939541 2017
28
Anaplastic Pleomorphic Xanthoastrocytoma in a Case of Neurofibromatosis Type 1: A Case Report. 38
28571159 2017
29
BRAF/MEK double blockade in refractory anaplastic pleomorphic xanthoastrocytoma. 38
28235815 2017
30
Dabrafenib in BRAFV600-mutated anaplastic pleomorphic xanthoastrocytoma. 38
27781490 2017
31
Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. 38
27624885 2016
32
[Epilepsy-associated tumors of the central nervous system: Epilepsy surgery and oncological aspects]. 38
26676655 2016
33
Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy. 38
25092772 2016
34
Primary anaplastic pleomorphic xanthoastrocytoma in adults. Case report and review of literature. 38
27639203 2016
35
Anaplastic pleomorphic xanthoastrocytoma with spinal leptomeningeal spread at the time of diagnosis in an adult. 38
25934112 2015
36
KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis. 38
25382612 2015
37
DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma. 38
24650279 2014
38
Primary multicentric anaplastic pleomorphic xanthoastrocytoma with atypical features. 38
23827171 2013
39
Clinical neuropathology practice news 2-2012: BRAF V600E testing. 38
22385786 2012
40
Establishment of a primary pleomorphic xanthoastrocytoma cell line: in vitro responsiveness to some chemotherapeutics. 38
21629132 2012
41
Anaplastic pleomorphic xanthoastrocytoma with a component of anaplastic astrocytoma presenting as skull base tumor followed by downward extracranial extension. Case report. 38
21206189 2010
42
Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis--a pediatric case report and review of the literature. 38
19326050 2009
43
Images in neuro-oncology: anaplastic pleomorphic xanthoastrocytoma. 38
16850109 2006
44
Clinicopathologic and genetic analysis of siblings with NF1 and adult-onset gliomas. 38
16725158 2006
45
Non-anaplastic pleomorphic xanthoastrocytoma with neuroradiological evidences of leptomeningeal dissemination. 38
16369851 2006
46
A case of anaplastic pleomorphic xanthoastrocytoma presenting with tumor bleeding and cerebrospinal fluid dissemination. 38
18095120 2006
47
Lipidized giant-cell glioblastoma of cerebellum. 38
16320820 2005
48
Cerebral anaplastic pleomorphic xanthoastrocytoma with meningeal dissemination at first presentation. 38
14669022 2004
49
Molecular genetic analysis of anaplastic pleomorphic xanthoastrocytoma. 38
12732498 2003
50
Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma. 38
15679305 2003

Variations for Anaplastic Pleomorphic Xanthoastrocytoma

Expression for Anaplastic Pleomorphic Xanthoastrocytoma

Search GEO for disease gene expression data for Anaplastic Pleomorphic Xanthoastrocytoma.

Pathways for Anaplastic Pleomorphic Xanthoastrocytoma

GO Terms for Anaplastic Pleomorphic Xanthoastrocytoma

Sources for Anaplastic Pleomorphic Xanthoastrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
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30 HGMD
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34 ICD10 via Orphanet
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36 IUPHAR
37 KEGG
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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