AAV
MCID: ANC002
MIFTS: 42

Anca-Associated Vasculitis (AAV)

Categories: Bone diseases, Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Anca-Associated Vasculitis

MalaCards integrated aliases for Anca-Associated Vasculitis:

Name: Anca-Associated Vasculitis 52 58
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 52 58 71
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis 52 58
Aav 52 58

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

MESH via Orphanet 44 D056648
UMLS via Orphanet 72 C2717865
Orphanet 58 ORPHA156152
UMLS 71 C2717865

Summaries for Anca-Associated Vasculitis

NIH Rare Diseases : 52 Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of diseases (granulomatosis with polyangiitis , eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis ), characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs , such as the kidney, stomach, intestine, and lung. Skin lesions, such as purpura and urticaria , result when blood from small vessels leaks under the skin. AAV occurs when neutrophils attack small and medium vessels of the body. The underlying reason for this remains unclear. Treatment includes cyclophosphamide , glucocorticoids and other autoimmune drugs such as rituximab .

MalaCards based summary : Anca-Associated Vasculitis, also known as anti-neutrophil cytoplasmic antibody-associated vasculitis, is related to microscopic polyangiitis and churg-strauss syndrome. An important gene associated with Anca-Associated Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and Phagosome. The drugs alemtuzumab and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, kidney and lung.

Wikipedia : 74 Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a long-term... more...

Related Diseases for Anca-Associated Vasculitis

Diseases related to Anca-Associated Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 629)
# Related Disease Score Top Affiliating Genes
1 microscopic polyangiitis 31.5 MPO HLA-DRB1 CTLA4
2 churg-strauss syndrome 31.5 PRTN3 MPO HMGB1
3 crescentic glomerulonephritis 31.4 PRTN3 MPO
4 glomerulonephritis 31.3 PRTN3 MPO C3
5 vasculitis 31.0 SERPINA1 PRTN3 MPO CTLA4 C3
6 mononeuritis multiplex 31.0 PRTN3 MPO
7 multiple cranial nerve palsy 30.7 PRTN3 MPO
8 exanthem 30.7 PRTN3 CTLA4
9 granulomatosis with polyangiitis 30.7 SERPINA1 PRTN3 MPO HMGB1 CTLA4
10 aortitis 30.7 PRTN3 MPO
11 mastoiditis 30.7 PRTN3 MPO
12 rapidly progressive glomerulonephritis 30.6 PRTN3 MPO C3
13 autoimmune vasculitis 30.6 PRTN3 MPO
14 polyarteritis nodosa 30.6 PRTN3 MPO HLA-DRB1
15 anti-basement membrane glomerulonephritis 30.4 PRTN3 MPO
16 autoimmune disease 30.4 PRTN3 HLA-DRB1 CTLA4 C3
17 proliferative glomerulonephritis 30.4 MPO C3
18 mononeuropathy 30.4 PRTN3 MPO
19 henoch-schoenlein purpura 30.3 PRTN3 MPO
20 pneumonia 30.3 SERPINA1 MPO HMGB1
21 lung disease 30.2 SERPINA1 PRTN3 MPO HMGB1
22 graves' disease 30.2 MPO HLA-DRB1 CTLA4
23 goodpasture syndrome 30.2 PRTN3 MPO HLA-DRB1
24 autoimmune hepatitis 30.0 HMGB1 HLA-DRB1 CTLA4
25 pulmonary disease, chronic obstructive 30.0 SERPINA1 PRTN3 MPO
26 respiratory failure 30.0 SERPINA1 MPO ANGPT2
27 alpha-1-antitrypsin deficiency 30.0 SERPINA1 PRTN3 MPO
28 hyperthyroidism 29.9 PRTN3 GHRL CTLA4
29 anemia, autoimmune hemolytic 29.9 CTLA4 C3
30 hypersensitivity vasculitis 29.8 PRTN3 MPO C3
31 ulcerative colitis 29.8 PRTN3 MPO HLA-DRB1
32 lupus erythematosus 29.7 HMGB1 HLA-DRB1 CTLA4 C3
33 colitis 29.7 MPO HLA-DRB1 CTLA4
34 temporal arteritis 29.7 PRTN3 MPO HLA-DRB1 CTLA4
35 kidney disease 29.7 PRTN3 HMGB1 CTLA4 C3
36 rheumatoid arthritis 29.4 PRTN3 MPO HMGB1 HLA-DRB1 CTLA4
37 primary biliary cirrhosis 29.3 PRTN3 HLA-DRB1 CTLA4
38 thrombotic thrombocytopenic purpura 29.3 HLA-DRB1 C3
39 celiac disease 1 29.2 HLA-DRB1 GHRL CTLA4
40 systemic lupus erythematosus 29.1 PRTN3 MPO HMGB1 HLA-DRB1 CTLA4 C3
41 cholangitis 29.1 PRTN3 MPO HLA-DRB1 CTLA4
42 inflammatory bowel disease 28.4 PRTN3 MPO HMGB1 HLA-DRB1 GHRL CTLA4
43 allergic angiitis 10.8
44 end stage renal failure 10.8
45 hemophilia b 10.6
46 muscular dystrophy 10.5
47 idiopathic interstitial pneumonia 10.5
48 pulmonary fibrosis 10.5
49 purpura 10.5
50 retinal degeneration 10.5

Graphical network of the top 20 diseases related to Anca-Associated Vasculitis:



Diseases related to Anca-Associated Vasculitis

Symptoms & Phenotypes for Anca-Associated Vasculitis

Drugs & Therapeutics for Anca-Associated Vasculitis

Drugs for Anca-Associated Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
alemtuzumab Approved, Investigational Phase 4 216503-57-0
2
Azathioprine Approved Phase 4 446-86-6 2265
3 Gastrointestinal Agents Phase 4
4 Antiemetics Phase 4
5 Protective Agents Phase 4
6 Neuroprotective Agents Phase 4
7 Tin Fluorides Phase 4
8 Autonomic Agents Phase 4
9
Mycophenolic acid Approved Phase 2, Phase 3 24280-93-1 446541
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11
Abatacept Approved Phase 3 332348-12-6 10237
12
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
13
leucovorin Approved Phase 3 58-05-9 6006 143
14
Acetaminophen Approved Phase 3 103-90-2 1983
15
Clemastine Approved, Investigational Phase 3 15686-51-8 26987
16
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
17
Ibuprofen Approved Phase 3 15687-27-1 3672
18
rituximab Approved Phase 3 174722-31-7 10201696
19
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
20
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
21
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
22 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
23
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
24
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
25
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
26
Dexchlorpheniramine Experimental, Investigational Phase 3 25523-97-1 33036
27 Antibodies Phase 3
28 Immunoglobulins Phase 3
29 Plasma Substitutes Phase 3
30 Immunosuppressive Agents Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Antineoplastic Agents, Hormonal Phase 3
33 Hormone Antagonists Phase 3
34 Hormones Phase 3
35 Complement System Proteins Phase 3
36 Alkylating Agents Phase 3
37 Antimetabolites Phase 3
38 Anti-Infective Agents Phase 3
39 Antibiotics, Antitubercular Phase 3
40 Antitubercular Agents Phase 3
41 Anti-Bacterial Agents Phase 3
42 Folic Acid Antagonists Phase 3
43 Vitamin B Complex Phase 3
44 Dermatologic Agents Phase 3
45 Folate Phase 3
46 Vitamin B9 Phase 3
47 Pharmaceutical Solutions Phase 3
48 Analgesics Phase 3
49 Analgesics, Non-Narcotic Phase 3
50 Anti-Inflammatory Agents, Non-Steroidal Phase 3

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Alemtuzumab for ANCA Associated Refractory Vasculitis - a Study of Safety and Efficacy Unknown status NCT01405807 Phase 4 Alemtuzumab
2 Short-Course Glucocorticoids and Rituximab in ANCA-Associated Vasculitis Completed NCT02169219 Phase 4 Glucocorticoids;Rituximab
3 Low-dose Glucocorticoids Plus Rituximab Versus High-dose Glucocorticoids Plus Rituximab for Remission Induction in ANCA-associated Vasculitis; a Multicentre, Open Label, Randomised Control Trial Recruiting NCT02198248 Phase 4 Rituximab;Glucocorticoids
4 Maintenance of ANCA Vasculitis Remission by Intermittent Rituximab Dosing Based on B-cell Reconstitution vs a Serologic ANCA Flare Recruiting NCT02749292 Phase 4 Rituximab
5 Prevention of Relapses in PR3-ANCA-associated Vasculitis, a Tailored Approach Terminated NCT00128895 Phase 4 azathioprine
6 Treatment of ANCA-Associated Vasculitides : Corticosteroids and Pulse Cyclophosphamide Followed by Maintenance Therapy With Methotrexate or Azathioprine: a Prospective Multicenter Randomized Trial Unknown status NCT00349674 Phase 3 Azathioprine: 2 mg/kg/day;methotrexate 0.3 mg/kg/week, to a maximum and optimal dose of 25 mg/week
7 Comparative Study of the Efficacy of Induction Therapy With Cyclophosphamide or Mycophenolate Mofetil for Non-Life-Threatening Relapses of PR3- or MPO-ANCA Associated Vasculitis Unknown status NCT00103792 Phase 3 mycophenolate mofetil;cyclophosphamide
8 Efficacy and Tolerance of First-line Treatment With Tocilizumab in Active Takayasu Arteritis French Prospective Multicenter Study Unknown status NCT02101333 Phase 3 Tocilizumab
9 A Randomized, Double-Blind, Active-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine Completed NCT02994927 Phase 3 CCX168;Prednisone;Cyclophosphamide;Azathioprine
10 MAINtenance of Remission Using RITuximab in Systemic ANCA-associated Vasculitis II Completed NCT01731561 Phase 3 Rituximab (Arm B);Rituximab (Arm A)
11 Randomized Trial of Intravenous Pulse Versus Oral Continuous Cyclophosphamide for Induction of Remission in Systemic ANCA-Associated Vasculitides Completed NCT00430105 Phase 2, Phase 3 cyclophosphamide
12 A Randomised Clinical Trial of Mycophenolate Mofetil Versus Cyclophosphamide for Remission Induction in ANCA Associated Vasculitis. Completed NCT00414128 Phase 2, Phase 3 mycophenolate mofetil;cyclophosphamide
13 MAINtenance of Remission Using RITuximab in Systemic ANCA-associated Vasculitis Completed NCT00748644 Phase 3 Rituximab;Azathioprine
14 Rituximab Therapy for the Induction of Remission and Tolerance in ANCA-Associated Vasculitis (ITN021AI) Completed NCT00104299 Phase 2, Phase 3 Rituximab plus cyclophosphamide placebo (rituximab group);Cyclophosphamide plus rituximab placebo (control group);Azathioprine;Methylprednisolone (or other glucocorticoid);Prednisone
15 Plasma Exchange and Glucocorticoid Dosing in the Treatment of Anti-neutrophil Cytoplasm Antibody Associated Vasculitis: an International Randomized Controlled Trial Completed NCT00987389 Phase 3 Glucocorticoids
16 Maintaining or Stopping Immunosuppressive Therapy in Patients With ANCA Vasculitis and End-stage Renal Disease: a Prospective, Multicenter, Randomized, Open-label, Clinical Trial Recruiting NCT03323476 Phase 3 Maintenance (or initiation) of immunosuppressive treatment: Imurel®, Mabthera®,Cellcept®, Cortancyl®
17 Abatacept (CTLA4-Ig) for the Treatment of Relapsing, Non-Severe, Granulomatosis With Polyangiitis (Wegener's) (ABROGATE) Recruiting NCT02108860 Phase 3 Abatacept;placebo
18 Evaluating Favorable, Immunological Effects of Rituximab With Cyclophosphamide Compared to Rituximab Alone in AAV Patients Recruiting NCT03942887 Phase 3 Rituximab;endoxan;Methylprednisolone;Prednisolone
19 The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach Recruiting NCT01933724 Phase 3 5 mg prednisone;0 mg prednisone
20 The Assessment of Prednisone In Remission Trial (TAPIR) - Centers of Excellence Approach Recruiting NCT01940094 Phase 3 5 mg Prednisone;0 mg Prednisone
21 The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children Attending Assiut University Hospital. Recruiting NCT03692416 Phase 3 Ibuprofen;Prednisone;Methotrexate
22 Extended Follow Up of the Mainritsan 2 Study. Comparison Between a Long Term and a Conventional Maintenance Treatment With Rituximab: a Placebo- Controlled Randomized Trial Active, not recruiting NCT02433522 Phase 3 rituximab;Placebo
23 An International, Open Label, Randomised Controlled Trial Comparing Rituximab With Azathioprine as Maintenance Therapy in Relapsing ANCA-associated Vasculitis Active, not recruiting NCT01697267 Phase 3 Azathioprine
24 Efficacy and Safety of Rituximab in the Treatment of Good Prognosis Microscopic Polyangiitis Not yet recruiting NCT03920722 Phase 3 Rituximab;placebo
25 Does CMV Reactivation Cause Functional Impairment of CMV Specific CD4+ T-cells? The Potential for Valaciclovir to Prevent CMV-mediated Adverse Modulation of the Immune System in Patients With ANCA-associated Vasculitis Unknown status NCT01633476 Phase 2 Valaciclovir
26 A Randomized, Double-Blind, Placebo-Controlled, Dose Assessment Phase 2 Study to Evaluate the Safety and Efficacy of CCX168 in Subjects With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Completed NCT02222155 Phase 2 CCX168 low dose plus standard of care;CCX168 high dose plus standard of care
27 Pilot Study of Rituximab Therapy for Systemic Lupus Erythematosus (SLE) and Vasculitis Resistant to Conventional Therapy Completed NCT00293072 Phase 2 Rituximab
28 Phase II Pilot Cohort Study to Investigate the Safety and Efficacy of Infliximab as Additional Therapy in the Treatment if Anti-Neutrophil Cytoplasm Antibody Associated Vasculitis Completed NCT00753103 Phase 2 Cyclophosphamide;Prednisolone;Azathioprine;Mycophenolate mofetil;Methylprednisolone
29 A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of CCX168 in Subjects With Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis on Background of Cyclophosphamide or Rituximab Treatment Completed NCT01363388 Phase 2 Placebo;CCX168
30 A Randomised, Double Blind, Controlled Mechanistic Study of Rituximab and Belimumab Combination Therapy in PR3 ANCA-associated Vasculitis Recruiting NCT03967925 Phase 2 Belimumab
31 Multicenter Randomized Controlled Trial Comparing Immunogenicity and Safety of Two Innovative Anti-pneumococcal Vaccine Strategies to Standard Vaccination Regimen in Patients With ANCA-associated Vasculitis Receiving Rituximab Therapy Recruiting NCT03069703 Phase 2 Rituximab
32 A Pilot Study to Evaluate the Efficacy and Safety of Pirfenidone in Patients With Pulmonary Fibrosis With Anti-myeloperoxydase (MPO) Antibodies or With Anti-MPO Associated Vasculitis." Recruiting NCT03385668 Phase 2 Pirfenidone
33 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase II Efficacy and Safety Study of IFX-1 in Add-On to Standard of Care in Granulomatosis With Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) Recruiting NCT03712345 Phase 2 IFX-1;IFX-1;Placebo
34 Acquired Immunodeficiency in ANCA (Antineutrophil Cytoplasmic Antibody) Associated Vasculitis Not yet recruiting NCT03514979 Phase 2
35 A Pilot Study Examining the Effect of Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
36 A Pilot Study on the Use of Rituximab in the Treatment of Churg- Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
37 Retinoids in ANCA Small Vessel Vasculitis: Silencing Autoantigens Withdrawn NCT01275274 Phase 2 Retinoic acid;Standard of care
38 Targeting Complement Activation in Antineutrophil Cytoplasmic Autoantibodies (ANCA)-Vasculitis Withdrawn NCT01275287 Phase 2 Standard of care treatment;eculizumab
39 A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of Blisibimod in Addition to Methotrexate During Induction of Remission in Subjects With ANCA-Associated Small Vessel Vasculitis Withdrawn NCT01598857 Phase 2 Blisibimod;Placebo
40 A Pilot Study of Mycophenolate Mofetil (MMF) in Patients With p-ANCA Microscopic Polyangiitis and Mild to Moderate Renal Dysfunction. Completed NCT00405860 Phase 1 CellCept (mycophenolate mofetil)
41 Immunogenicity of a Combined Anti-pneumococcal Vaccine Schedule in Patients With ANCA-associated Vasculitis: a Pilot Study Following New Vaccine Recommendations. PneumoVas Pilot 2 Unknown status NCT02463578
42 Cohort Study of Chinese Patients With Pulmonary Vasculitis Unknown status NCT02126098
43 Differing Levels of Positive Anti-Neutrophil Cytoplasm Antibody (ANCA) Test and Their Correlation With Vasculitis or Malignancy or Chronic Inflammation Unknown status NCT02180126
44 A Qualitative Study Using Interviews With Patients Who Have Anti-neutrophil Cytoplasm Antibody (ANCA) Associated Vasculitis, to Develop a Patient Reported Outcome (PRO) Measure Unknown status NCT01729624
45 Neutrophils Function and Identification of Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis). Unknown status NCT01862068
46 Eosinophilic Granulomatosis With Polyangiitis Cohort Unknown status NCT03036670
47 Residual Anti-pneumococcal Immunity After Pneumococcal Immunization in ANCA-associated Vasculitis. PneumoVas Pilot 1 Completed NCT02463539
48 Mycophenolate Mofetil Versus Cyclophosphamide in the Induction Treatment of ANCA Associated Vasculitis Completed NCT00301652 mycophenolate mofetil
49 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
50 A Prospective Cohort Study in 6 Swiss Rheumatology Centres and 4 Travel Clinics on the Immunogenicity and Safety of Tetanus and Hepatitis A Vaccine in Patients With Rheumatoid Arthritis, Axial Spondyloarthritis and Vasculitis and Healthy Controls Completed NCT01947465

Search NIH Clinical Center for Anca-Associated Vasculitis

Genetic Tests for Anca-Associated Vasculitis

Anatomical Context for Anca-Associated Vasculitis

MalaCards organs/tissues related to Anca-Associated Vasculitis:

40
Neutrophil, Kidney, Lung, B Cells, T Cells, Skin, Heart

Publications for Anca-Associated Vasculitis

Articles related to Anca-Associated Vasculitis:

(show top 50) (show all 2004)
# Title Authors PMID Year
1
Complement alternative pathway in ANCA-associated vasculitis: Two decades from bench to bedside. 61
31734405 2020
2
No evident association of nasal carriage of Staphylococcus aureus or its small-colony variants with cotrimoxazole use or ANCA-associated vasculitis relapses. 61
31834404 2020
3
Predictor of depressive disorders in patients with antineutrophil cytoplasmic antibody-associated vasculitis. 61
31312987 2019
4
Double positivity for antineutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane antibody could predict end-stage renal disease in ANCA-associated vasculitis: a monocentric pilot study. 61
31802348 2019
5
Kidney transplantation in ANCA-associated vasculitis. 61
31471816 2019
6
Controlling Nutritional Status Score is Associated with All-Cause Mortality in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
31769247 2019
7
Update on ANCA-associated vasculitis: from biomarkers to therapy. 61
31301058 2019
8
[ANCA and anti-MBG double-positive vasculitis: An update on the clinical and therapeutic specificities and comparison with the two eponymous vasculitis]. 61
31839271 2019
9
All-cause and cause-specific mortality in ANCA-associated vasculitis: overall and according to ANCA type. 61
31846030 2019
10
Serum IgG4 level and IgG4 subclass of ANCA as disease biomarker for ANCA-associated vasculitis. 61
31811700 2019
11
Prevalence and management of cardiovascular risk factors in ANCA-associated vasculitis. 61
31243446 2019
12
Glucocorticoid-free induction regimen in severe ANCA-associated vasculitis using a combination of rituximab and eculizumab. 61
31102526 2019
13
Reduced activated regulatory T cells and imbalance of Th17/activated Treg cells marks renal involvement in ANCA-associated vasculitis. 61
31837507 2019
14
Evaluation of 12 different assays for detecting ANCA in Chinese patients with GPA and MPA: a multicenter study in China. 61
31414304 2019
15
Bartonella endocarditis masquerading as systemic vasculitis with rapidly progressive glomerulonephritis (aka 'Löhlein nephritis'). 61
31801777 2019
16
B cell targeted therapies in autoimmune disease. 61
31733607 2019
17
Effect of high mobility group box 1 on Toll-like receptor 9 in B cells in myeloperoxidase-ANCA-associated vasculitis. 61
31790283 2019
18
Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Compared to Systemic Lupus Erythematosus. 61
31313503 2019
19
The association of serum interleukin-6 levels with clinical outcomes in antineutrophil cytoplasmic antibody-associated vasculitis. 61
31320177 2019
20
Childhood GPA, EGPA, and MPA. 61
31837445 2019
21
Spectrum and prognosis of ANCA-associated vasculitis-related bronchiectasis: data from 61 patients. 61
31787599 2019
22
Remission maintenance in ANCA-associated vasculitis: does one size fit all? 61
31762340 2019
23
Autologous haematopoietic stem cell transplantation (HSCT) for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: a retrospective survey of patients reported to European Society for Blood and Marrow Transplantation (EBMT) registry. 61
31848450 2019
24
Antineutrophil Cytoplasmic Antibodies Testing and Interpretation. 61
31668268 2019
25
Urinary mitochondrial DNA is a useful biomarker for assessing kidney injury of antineutrophil cytoplasmic antibody -associated vasculitis. 61
31758933 2019
26
PR3-ANCA-associated vasculitis is associated with a specific motif in the peptide-binding cleft of HLA-DP molecules. 61
30938436 2019
27
The effect of pulse methylprednisolone induction therapy in Chinese patients with dialysis-dependent MPO-ANCA associated vasculitis. 61
31536905 2019
28
Disease Activity, Antineutrophil Cytoplasmic Antibody Type, and Lipid Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
31162829 2019
29
Measuring Circulating Complement Activation Products in Myeloperoxidase- and Proteinase 3-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
31215772 2019
30
Cytokine profiling in anti neutrophil cytoplasmic antibody-associated vasculitis: a cross-sectional cohort study. 61
31286195 2019
31
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis. 61
31756913 2019
32
Association of Pulmonary Hemorrhage, Positive Proteinase 3, and Urinary Red Blood Cell Casts With Venous Thromboembolism in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
31216123 2019
33
Clinical characteristics of patients with vasculitis positive for anti-neutrophil cytoplasmic antibody targeting both proteinase 3 and myeloperoxidase: a retrospective study. 61
31552433 2019
34
Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. 61
31764171 2019
35
Aortitis caused by antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a case-based review. 61
31222438 2019
36
Acute tubulointerstitial nephritis with germinal centers in antineutrophil cytoplasmic antibody-associated vasculitis: A case report and literature review. 61
31770269 2019
37
Clinical significance of ANCA positivity in patients with IgA vasculitis: a retrospective monocentric study. 61
31372719 2019
38
Peripheral neuropathy in antineutrophil cytoplasmic antibody-associated vasculitides: Insights from the DCVAS study. 61
31540965 2019
39
New perspectives in eosinophilic granulomatosis with polyangiitis (EGPA): report of the first meeting of the European EGPA Study Group. 61
31388893 2019
40
Measuring vasculitis with numbers: outcome scores. 61
31804163 2019
41
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status. 61
31719529 2019
42
Systemic calprotectin and chronic inflammatory rheumatic diseases. 61
30660804 2019
43
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population. 61
31705128 2019
44
Simultaneous Occurrence of Sarcoidosis and Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis in a Patient with Lung Cancer. 61
31327832 2019
45
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo. 61
31776158 2019
46
ANCA-Associated Vasculitis in Inflammatory Bowel Disease. 61
31093814 2019
47
Predominant Involvement of the Aortic Root in a Patient with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: Congestive Heart Failure due to Subacute Severe Aortic Regurgitation and Reversible Conduction Disturbance. 61
31708549 2019
48
Clinical Effect of Alpha-1 Antitrypsin Deficiency in Antineutrophil Cytoplasmic Antibody-associated Vasculitis: Results from a French Retrospective Monocentric Cohort. 61
30824651 2019
49
Biologics for childhood systemic vasculitis. 61
30203375 2019
50
Infectious profile in inpatients with ANCA-associated vasculitis: a single-center retrospective study from Southern China. 61
31576488 2019

Variations for Anca-Associated Vasculitis

Expression for Anca-Associated Vasculitis

Search GEO for disease gene expression data for Anca-Associated Vasculitis.

Pathways for Anca-Associated Vasculitis

Pathways related to Anca-Associated Vasculitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 SERPINA1 PRTN3 MPO HMGB1 HLA-DRB1 CTLA4
2 10.98 MPO HLA-DRB1 C3
3 10.94 MPO HMGB1
4 10.42 MPO HMGB1

GO Terms for Anca-Associated Vasculitis

Cellular components related to Anca-Associated Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.5 SERPINA1 GHRL C3
2 extracellular region GO:0005576 9.5 SERPINA1 PRTN3 MPO HMGB1 GHRL C3
3 secretory granule lumen GO:0034774 9.43 HMGB1 GHRL C3
4 azurophil granule lumen GO:0035578 9.33 PRTN3 MPO C3
5 extracellular space GO:0005615 9.17 SERPINA1 PRTN3 MPO HMGB1 GHRL C3

Biological processes related to Anca-Associated Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.56 HMGB1 HLA-DRB1 CTLA4 C3
2 negative regulation of T cell proliferation GO:0042130 9.43 HLA-DRB1 CTLA4
3 negative regulation of blood vessel endothelial cell migration GO:0043537 9.4 HMGB1 ANGPT2
4 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.37 HLA-DRB1 GHRL
5 negative regulation of interferon-gamma production GO:0032689 9.32 HMGB1 HLA-DRB1
6 positive regulation of vascular endothelial cell proliferation GO:1905564 9.16 HMGB1 GHRL
7 neutrophil degranulation GO:0043312 9.02 SERPINA1 PRTN3 MPO HMGB1 C3
8 inflammatory response to antigenic stimulus GO:0002437 8.96 HMGB1 HLA-DRB1

Sources for Anca-Associated Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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