MCID: ANC001
MIFTS: 39

Ancylostomiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Ancylostomiasis

MalaCards integrated aliases for Ancylostomiasis:

Name: Ancylostomiasis 12 20 58 44 15 17 70 32
Hookworm Infections 54 70
Hookworm Infection 20 58
Ankylostomiasis 20 58
Ancylostomiasis Due to Ancylostoma Duodenale 70
Ancylostoma Duodenale Infection 20

Characteristics:

Orphanet epidemiological data:

58
ankylostomiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:12841
MeSH 44 D000724
NCIt 50 C35805
SNOMED-CT 67 85807000
ICD10 32 B76.0
MESH via Orphanet 45 D000724 D006725
ICD10 via Orphanet 33 B76.0 B76.1 B76.8 more
UMLS via Orphanet 71 C0002831 C0019911
Orphanet 58 ORPHA78
UMLS 70 C0002831 C0019911 C1384687

Summaries for Ancylostomiasis

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 78 Definition A hookworm infection caused primarily by the species Ancylostoma duodenale or Necator americanus, usually acquired through penetration of the skin, (often asymptomatic but that can also manifest with an allergic reaction at the site of skin penetration), followed by the migration of larva through the bloodstream to the lungs (causing asymptomatic pneumonitis, eosinophilia) and finally reaching and colonizing the small intestines where they cause blood extravasation leading to diarrhea, abdominal pain, and when untreated, melena, iron-deficiency anemia and protein malnutrition.

MalaCards based summary : Ancylostomiasis, also known as hookworm infections, is related to parasitic helminthiasis infectious disease and taeniasis, and has symptoms including anemia, abdominal pain and intestinal bleeding. An important gene associated with Ancylostomiasis is HHAT (Hedgehog Acyltransferase). The drugs Pyrantel and Oxantel have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and small intestine.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has symptom intestinal bleeding, has symptom abdominal pain, has symptom anemia, has symptom severe diarrhea and has symptom malnutrition.

Wikipedia : 73 Ancylostomiasis is a hookworm disease caused by infection with Ancylostoma hookworms. The name is... more...

Related Diseases for Ancylostomiasis

Diseases related to Ancylostomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 parasitic helminthiasis infectious disease 30.0 TES MT-CO1
2 taeniasis 29.8 TES MT-CO1
3 enterobiasis 29.6 TES MT-CO1
4 strongyloidiasis 29.5 TES MT-CO1
5 ascaridiasis 10.5
6 ascaris lumbricoides infection 10.4
7 deficiency anemia 10.3
8 celiac disease 1 10.2
9 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
10 filarial elephantiasis 10.2
11 duodenal ulcer 10.2
12 schistosoma mansoni infection, susceptibility/ 10.2
13 schistosomiasis 10.2
14 allergic asthma 10.1
15 hypereosinophilic syndrome 10.1
16 opisthorchiasis 10.1
17 cutaneous larva migrans 10.1
18 trichuriasis 10.1
19 iron metabolism disease 10.1
20 alveolar soft part sarcoma 10.0
21 mycobacterium tuberculosis 1 10.0
22 disease by infectious agent 10.0
23 nephrotic syndrome 10.0
24 pulmonary embolism 10.0
25 gnathomiasis 10.0 TES MT-CO1
26 hymenolepiasis 10.0 TES MT-CO1
27 malaria 10.0
28 cysticercosis 10.0
29 filariasis 10.0
30 iron deficiency anemia 10.0
31 allergic disease 10.0
32 amebiasis 10.0
33 nivelon-nivelon-mabille syndrome 10.0 NR5A1 HHAT
34 oesophagostomiasis 9.9
35 ige responsiveness, atopic 9.9
36 body mass index quantitative trait locus 11 9.9
37 helicobacter pylori infection 9.9
38 asthma 9.9
39 body mass index quantitative trait locus 9 9.9
40 body mass index quantitative trait locus 8 9.9
41 allergic rhinitis 9.9
42 body mass index quantitative trait locus 4 9.9
43 body mass index quantitative trait locus 10 9.9
44 body mass index quantitative trait locus 7 9.9
45 body mass index quantitative trait locus 12 9.9
46 acute promyelocytic leukemia 9.9
47 body mass index quantitative trait locus 14 9.9
48 chitotriosidase deficiency 9.9
49 graft-versus-host disease 9.9
50 body mass index quantitative trait locus 18 9.9

Graphical network of the top 20 diseases related to Ancylostomiasis:



Diseases related to Ancylostomiasis

Symptoms & Phenotypes for Ancylostomiasis

Symptoms:

12
  • anemia
  • abdominal pain
  • intestinal bleeding
  • malnutrition
  • severe diarrhea

Drugs & Therapeutics for Ancylostomiasis

Drugs for Ancylostomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2
Oxantel Experimental Phase 4 36531-26-7
3 Neuromuscular Blocking Agents Phase 4
4
Oxantel pamoate Phase 4 68813-55-8 5281086
5 Pyrantel Pamoate Phase 4
6
Albendazole Approved, Vet_approved Phase 2, Phase 3 54965-21-8 2082
7
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
8 Antiprotozoal Agents Phase 2, Phase 3
9 Milbemycin Phase 2, Phase 3
10 Gastrointestinal Agents Phase 2
11 Adjuvants, Immunologic Phase 2
12 Antacids Phase 2
13 Pharmaceutical Solutions Phase 2
14 Anti-Ulcer Agents Phase 2
15 Immunologic Factors Phase 2
16
Iron Approved Phase 1 7439-89-6 23925 29936
17
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
18
Imidazole Experimental, Investigational Phase 1 288-32-4 795
19 Monophosphoryl lipid A Phase 1
20 CPG-oligonucleotide Phase 1
21 Interferon-gamma Phase 1
22 interferons Phase 1
23 Interleukin-12 Phase 1
24 Vaccines Phase 1

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Different Drug Combinations Against Hookworm Infection in School-aged Children in the Lao People's Democratic Republic, a Single Blind, Randomised Controlled Trial Completed NCT03278431 Phase 4 Albendazole;Pyrantel Pamoate;Oxantel Pamoate;Mebendazole
2 Efficacy and Safety of a Single-dose Regimen and a Multi-dose Regimen of Mebendazole Against Hookworm Infections in School Children: a Randomized Controlled Trial Completed NCT03245398 Phase 4 Treatment with one of the two regimens of mebendazole
3 Efficacy and Safety of a Single-dose Regimen and a Multi-dose Regimen of Mebendazole Against Hookworm Infections in Children and Adolescents in Ghana: a Randomized Controlled Trial Withdrawn NCT03261596 Phase 4 Mebendazole
4 Efficacy and Safety of Moxidectin and Albendazole Compared to Ivermectin and Albendazole Co-administration in Adolescents Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04700423 Phase 2, Phase 3 moxidectin (8 mg) / albendazole (400 mg);ivermectin (200 µg/kg) / albendazole (400 mg);ALBENDAZOLE 400 Mg ORAL TABLET [ZENTEL];ivermectin (200 µg/kg);moxidectin (8 mg)
5 Efficacy and Safety of Combination Moxidectin and Albendazole, Ivermectin and Albendazole and Albendazole Alone in Adolescents and Adults Infected With Trichuris Trichiura: a Randomized Controlled Trial Not yet recruiting NCT04726969 Phase 3 Moxidectin 2 mg Oral Tablet;Albendazole 400 mg Oral Tablet;Ivermectin 3 mg Oral Tablet
6 Efficacy and Safety of a New Chewable Tablet of Mebendazole Versus the Swallowable, Standard Tablet of Mebendazole Against Hookworm Infections in Children: a Randomized Controlled Trial Completed NCT03995680 Phase 2 Mebendazole
7 Efficacy and Safety of Ascending Dosages of Albendazole Against T. Trichiura and Hookworm in Preschool- and School-aged Children and Adults: a Randomized Controlled Trial Completed NCT03527745 Phase 2 Albendazole;Albendazole;Albendazole;Albendazole;Placebo
8 Phase 2 Study to Assess the Safety, Efficacy and Immunogenicity of Na-GST-1/Alhydrogel Co-administered With Different Toll-Like Receptor Agonists in Hookworm- Naïve Adults Active, not recruiting NCT03172975 Phase 2 Albendazole
9 Phase 1 Study of the Safety and Immunogenicity of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel® in Brazilian Adults Completed NCT02476773 Phase 1
10 Phase I Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel® With Different Doses of the Novel Immunostimulant GLA-AF in Healthy Adults Completed NCT01385189 Phase 1
11 Phase 1 Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel® With or Without GLA-AF in Brazilian Adults Completed NCT01261130 Phase 1
12 Phase 1 Study of the Safety and Immunogenicity of Na-APR-1 (M74)/Alhydrogel® in Healthy Adults Completed NCT01717950 Phase 1
13 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Na-GST-1/Alhydrogel®, With or Without a CPG ODN Adjuvant, in Gabonese Adults Completed NCT03373214 Phase 1
14 Phase 1 Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel, With or Without a CpG ODN Adjuvant, in Healthy Adults Completed NCT02143518 Phase 1
15 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Co-administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 Adjuvanted With Alhydrogel® and Gluco-pyranosylphospho-lipid A in Gabonese Adults Completed NCT02126462 Phase 1
16 Phase 1, Single-Center, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study to Compare the Safety, Tolerability, and Immunogenicity of Three Intramuscular Administrations of Na-ASP-2 Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection Completed NCT00120081 Phase 1
17 Hookworm Therapy for Coeliac Disease: A Phase 1B Safety and Dose-ranging Clinical Trial Examining Sustained Gluten Consumption in Hookworm-naive and Hookworm-infection People With Coeliac Disease Completed NCT02754609 Phase 1
18 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Co-administered Hookworm Vaccine Candidates Na-APR-1 (M74)/Alhydrogel® and Na-GST-1/ Alhydrogel® in Gabonese Children Completed NCT02839161 Phase 1
19 An Experimental Infection Study of Dermally-applied Infectious Necator Americanus Hookworm Larvae in Hookworm-naïve Adults Active, not recruiting NCT01940757 Phase 1
20 Double-blind, Randomized, Controlled Phase 1 Study of the Safety and Immunogenicity of Na-ASP-2 Hookworm Vaccine in Previously-Infected Brazilian Adults Terminated NCT00473967 Phase 1
21 A Randomized Effectiveness Trial of Hookworm Treatment of Women Smallholder Farmers to Evaluate Improved Productivity of Their Farming and/or Household Labor Unknown status NCT02102321 albendazole;placebo
22 Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma Completed NCT00469989
23 Development of a Skin Test to Detect Immediate-type Hypersensitivity to the Experimental Na-ASP-2 Hookworm Antigen Completed NCT00603889
24 Determination of Prevalence and Intensity of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Northeastern Minas Gerais, Brazil Completed NCT00939198
25 Immunisation, Treatment and Controlled Human Hookworm Infection Completed NCT03702530
26 Randomised Controlled Clinical Trial of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis Completed NCT00232518
27 Shoes for Kids on the Island of Pemba (SKIP): A Pragmatic, Cluster Randomised Controlled Trial to Test if Shoes Reduce Hookworm Infection and Transmission in School-aged Children on Pemba Island, Zanzibar Completed NCT01869127
28 Repeated Controlled Human Hookworm Infection in Healthy Dutch Volunteers Completed NCT03257072
29 Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma. Completed NCT01163877
30 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
31 Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection Active, not recruiting NCT02262403
32 Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center Active, not recruiting NCT03126552
33 Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial Active, not recruiting NCT04227834

Search NIH Clinical Center for Ancylostomiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albendazole
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: ancylostomiasis

Genetic Tests for Ancylostomiasis

Anatomical Context for Ancylostomiasis

MalaCards organs/tissues related to Ancylostomiasis:

40
Skin, Bone Marrow, Small Intestine, Thymus, Monocytes, Lung, Placenta

Publications for Ancylostomiasis

Articles related to Ancylostomiasis:

(show top 50) (show all 874)
# Title Authors PMID Year
1
In vivo and in vitro efficacy of a single dose of albendazole against hookworm infection in northwest Ethiopia: open-label trial. 61
33743835 2021
2
A Randomized Controlled Trial to Investigate Safety and Variability of Egg Excretion After Repeated Controlled Human Hookworm Infection. 61
32645714 2021
3
Hookworm infection in infants: a case report and review of literature. 61
33563313 2021
4
Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans. 61
33318013 2021
5
Agar Plate Culture: An Alternative Sensitive Routine Laboratory Detection Method for Strongyloides stercoralis and Hookworm Parasites. 61
33786049 2021
6
Hotspots and correlates of soil-transmitted helminth infections in a Venezuelan rural community: Which are the "wormy" houses? 61
33271168 2021
7
Socioenvironmental Factors Influencing Distribution and Intensity of Soil-Transmitted Helminthiasis in the Brazilian Amazon: Challenges for the 2030 Agenda. 61
33613673 2021
8
Pharmacometric Analysis of Tribendimidine Monotherapy and Combination Therapies To Achieve High Cure Rates in Patients with Hookworm Infections. 61
33139276 2021
9
Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection. 61
33139293 2021
10
Morphological and Molecular Diagnosis of Necator americanus and Ancylostoma ceylanicum Recovered from Villagers in Northern Cambodia. 61
33412765 2020
11
Randomized, Placebo Controlled Trial of Experimental Hookworm Infection for Improving Gluten Tolerance in Celiac Disease. 61
33512796 2020
12
Baseline patterns of infection in regions of Benin, Malawi and India seeking to interrupt transmission of soil transmitted helminths (STH) in the DeWorm3 trial. 61
33137100 2020
13
Efficacy, safety and acceptability of a new chewable formulation versus the solid tablet of mebendazole against hookworm infections in children: An open-label, randomized controlled trial. 61
33150325 2020
14
An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections. 61
32956390 2020
15
Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis. 61
32342850 2020
16
[Polarization of human acute monocytic leukemia THP-1 cells-derived macprophages induced by Nippostrongylus brasiliensis proteins in vitro]. 61
32935510 2020
17
The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. 61
32574160 2020
18
Making the Difference in Occupational Health: Three Original and Significant Cases Presented at ICOH Congresses in the 20th Century. 61
32596018 2020
19
High-throughput multiplex qPCRs for the surveillance of zoonotic species of canine hookworms. 61
32542036 2020
20
A holistic approach is needed to control the perpetual burden of soil-transmitted helminth infections among indigenous schoolchildren in Malaysia. 61
32249689 2020
21
Semi-domesticated dogs as a potential reservoir for zoonotic hookworms in Bangkok, Thailand. 61
32636587 2020
22
Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial. 61
32460712 2020
23
Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation. 61
32238181 2020
24
Efficacy of Simparica Trio™, a novel chewable tablet containing sarolaner, moxidectin and pyrantel, against induced hookworm infections in dogs. 61
32113471 2020
25
Insights into hookworm prevalence in Asia: a systematic review and meta-analysis. 61
31917423 2020
26
Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes. 61
33042153 2020
27
A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum. 61
33324163 2020
28
Effects of nutritional supplements on the re-infection rate of soil-transmitted helminths in school-age children: A systematic review and meta-analysis. 61
32790693 2020
29
Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya. 61
32351578 2020
30
[Investigation on human hookworm infections in Anhui Province from 2014 to 2015]. 61
32185934 2020
31
Distribution of ascariasis, trichuriasis and hookworm infections in Ogun State, Southwestern Nigeria. 61
32511237 2020
32
Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? 61
31818311 2019
33
Sustained preventive chemotherapy for soil-transmitted helminthiases leads to reduction in prevalence and anthelminthic tablets required. 61
31575378 2019
34
[Progress of research on host immune responses induced by hookworm infection and its potential therapeutic values]. 61
31713396 2019
35
Hookworm infection aggravates metabolic disorder in obesity. 61
31306675 2019
36
The mitochondrial genome of the dog hookworm Ancylostoma caninum (Nematoda, Ancylostomatidae) from Southwest China. 61
33365829 2019
37
A Half-Century Studies on Epidemiological Features of Ancylostomiasis in China: A Review Article. 61
31700811 2019
38
A Case of Cutaneous Larva Migrans in a Child from Vinces, Ecuador. 61
31543509 2019
39
Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16. 61
31486912 2019
40
Efficacy and Safety of Ascending Dosages of Tribendimidine Against Hookworm Infections in Children: A Randomized Controlled Trial. 61
30496350 2019
41
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections. 61
31077279 2019
42
HLA-G expression during hookworm infection in pregnant women. 61
31078470 2019
43
Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control. 61
30648601 2019
44
Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters. 61
31133690 2019
45
A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection. 61
31009474 2019
46
Correlation between hematological parameters and ancylostomiasis: A retrospective study. 61
30390342 2019
47
ANCYLOSTOMIASIS CAUSING UPPER GASTROINTESTINAL BLEEDING: REAL-TIME ENDOSCOPIC PICTURES. 61
30946305 2019
48
Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. 61
28711437 2019
49
Modified Harada-Mori and simple wet mount to determine hookworm infections in Yo Island urban area, Songkhla, Southern Thailand. 61
31049017 2019
50
Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study. 61
30589847 2018

Variations for Ancylostomiasis

Expression for Ancylostomiasis

Search GEO for disease gene expression data for Ancylostomiasis.

Pathways for Ancylostomiasis

GO Terms for Ancylostomiasis

Biological processes related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 8.62 MT-CO1 GCLM

Sources for Ancylostomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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