MCID: ANC001
MIFTS: 48

Ancylostomiasis

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Ancylostomiasis

MalaCards integrated aliases for Ancylostomiasis:

Name: Ancylostomiasis 12 53 44 15 73
Hookworm Infections 55 73
Ancylostomiasis Due to Ancylostoma Duodenale 73
Ancylostoma Duodenale Infection 53
Hookworm Infection 53

Classifications:



External Ids:

Disease Ontology 12 DOID:12841
ICD10 33 B76.0
MeSH 44 D000724
NCIt 50 C35805
SNOMED-CT 68 63479002 85807000

Summaries for Ancylostomiasis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 78Disease definitionAnkylostomiasis is a hookworm infection caused primarily by the species Ancylostoma duodenale or Necator americanus, usually acquired through penetration of the skin, (often asymptomatic but that can also manifest with an allergic reaction at the site of skin penetration), followed by the migration of larva through the bloodstream to the lungs (causing asymptomatic pneumonitis, eosinophilia) and finally reaching and colonizing the small intestines where they cause blood extravasation leading to diarrhea, abdominal pain, and when untreated, melena, iron-deficiency anemia and protein malnutrition.Visit the Orphanet disease page for more resources.

MalaCards based summary : Ancylostomiasis, also known as hookworm infections, is related to iron metabolism disease and protein-energy malnutrition, and has symptoms including anemia, abdominal pain and intestinal bleeding. An important gene associated with Ancylostomiasis is SLC25A46 (Solute Carrier Family 25 Member 46), and among its related pathways/superpathways are NRF2 pathway and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. The drugs Albendazole and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and small intestine, and related phenotype is homeostasis/metabolism.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has symptom intestinal bleeding, has symptom abdominal pain, has symptom anemia, has symptom severe diarrhea and has symptom malnutrition.

Wikipedia : 76 Ancylostomiasis (also anchylostomiasis or ankylostomiasis) is a hookworm disease caused by infection... more...

Related Diseases for Ancylostomiasis

Diseases related to Ancylostomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 iron metabolism disease 29.9 CP TF
2 protein-energy malnutrition 29.8 CP TF
3 ankylostomiasis 11.8
4 necatoriasis 11.1
5 schistosomiasis 10.2
6 phacolytic glaucoma 10.1 NR5A1 SERPINA1
7 diphyllobothriasis 10.1 MT-CO1 SERPINA1
8 boutonneuse fever 10.1 CP SERPINA1
9 holoprosencephaly 1 10.1 MT-CO1 SERPINA1
10 taeniasis 10.1
11 trichuriasis 10.1
12 hypochromic microcytic anemia 10.1 CP TF
13 granulosa cell tumor of the ovary 10.1 CP SERPINA1
14 paragonimiasis 10.0 MT-CO1 RNASE3
15 eales disease 10.0 CP TF
16 congenital disorder of glycosylation, type iii 10.0 SERPINA1 TF
17 retinitis pigmentosa 7 10.0 SERPINA1 TF
18 deficiency anemia 10.0
19 urinary schistosomiasis 10.0
20 hemosiderosis 10.0 CP TF
21 siderosis 10.0 SERPINA1 TF
22 metal metabolism disorder 10.0 CP TF
23 fructose intolerance, hereditary 9.9 SERPINA1 TF
24 vernal conjunctivitis 9.9 RNASE3 TF
25 ascaris lumbricoides infection 9.9
26 malaria 9.9
27 hepatitis 9.9
28 hepatitis b 9.9
29 salmonellosis 9.9
30 cysticercosis 9.9
31 filariasis 9.9
32 chagas disease 9.9
33 shigellosis 9.9
34 trichostrongylosis 9.9
35 hypogonadism 9.9
36 ascaridiasis 9.9
37 pellagra 9.9
38 dwarfism 9.9
39 hemochromatosis, type 1 9.9 CP SERPINA1 TF
40 testicular yolk sac tumor 9.9 SERPINA1 TF
41 celiac disease 1 9.9
42 asthma 9.9
43 chitotriosidase deficiency 9.9
44 intestinal schistosomiasis 9.9
45 strongyloidiasis 9.9
46 trachoma 9.9
47 iron deficiency anemia 9.9
48 opisthorchiasis 9.9
49 dracunculiasis 9.9
50 dyspepsia 9.9

Graphical network of the top 20 diseases related to Ancylostomiasis:



Diseases related to Ancylostomiasis

Symptoms & Phenotypes for Ancylostomiasis

Symptoms:

12
  • anemia
  • abdominal pain
  • intestinal bleeding
  • malnutrition
  • severe diarrhea

MGI Mouse Phenotypes related to Ancylostomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 CP CYGB EGR3 EPGN GCLC GCLM

Drugs & Therapeutics for Ancylostomiasis

Drugs for Ancylostomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 2,Not Applicable 54965-21-8 2082
2
Piperazine Approved, Vet_approved Phase 4,Phase 3 110-85-0 4837
3
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
4
Mebendazole Approved, Vet_approved Phase 4,Phase 3,Not Applicable 31431-39-7 4030
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 77-92-9 311
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Antiprotozoal Agents Phase 4,Phase 2,Not Applicable
8 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Antimitotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Anthelmintics Phase 4,Phase 3,Phase 2,Not Applicable
11 Peripheral Nervous System Agents Phase 4
12 Piperazine citrate Phase 4,Phase 3
13 Citrate Phase 4,Phase 3,Not Applicable
14 Neuromuscular Depolarizing Agents Phase 4
15 Neuromuscular Blocking Agents Phase 4
16 Pyrantel Pamoate Phase 4
17 Neuromuscular Agents Phase 4
18
Oxantel pamoate Phase 4 68813-55-8 5281086
19 Oxantel Phase 4
20
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
21
Aluminum hydroxide Approved, Investigational Phase 2,Phase 1 21645-51-2
22 Immunologic Factors Phase 2,Phase 1,Not Applicable
23 Vaccines Phase 2,Phase 1,Not Applicable
24 Cayenne Phase 2
25 Anti-Ulcer Agents Phase 2,Phase 1
26 Pharmaceutical Solutions Phase 2,Phase 1,Not Applicable
27 Adjuvants, Immunologic Phase 2,Phase 1
28 Antacids Phase 2,Phase 1
29 Gastrointestinal Agents Phase 2,Phase 1
30
Iron Approved Phase 1,Not Applicable 7439-89-6 23925
31
Imidazole Experimental, Investigational Phase 1 288-32-4 795
32 Interleukin-12 Phase 1
33 CPG-oligonucleotide Phase 1
34 interferons Phase 1
35 Interferon-gamma Phase 1
36 Monophosphoryl lipid A Phase 1
37
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
38 Micronutrients Not Applicable
39 Trace Elements Not Applicable

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Triple Combinations Against Hookworm Infections in Lao Completed NCT03278431 Phase 4 Albendazole;Pyrantel Pamoate;Oxantel Pamoate;Mebendazole
2 Efficacy and Safety of a Multi-dose Regimen of Mebendazole Against Hookworm in Children Completed NCT03245398 Phase 4 Treatment with one of the two regimens of mebendazole
3 Impact of Alternative Treatment Strategies and Delivery Systems for Soil-transmitted Helminths in Kenya Completed NCT02397772 Phase 4 albendazole
4 Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana Withdrawn NCT03261596 Phase 4 Mebendazole
5 Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections Completed NCT01350271 Phase 3 Mebendazole polymorph A and C 500 mg;Mebendazole polymorph C;Placebo
6 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
7 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
8 Albendazole Dose Finding and Pharmacokinetics in Children and Adults Recruiting NCT03527745 Phase 2 Albendazole;Albendazole;Albendazole;Albendazole;Placebo
9 Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection Recruiting NCT03172975 Phase 2 Albendazole
10 Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection Completed NCT00120081 Phase 1
11 Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian Adults Completed NCT01261130 Phase 1
12 Study of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel in Brazilian Adults Completed NCT02476773 Phase 1
13 Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese Adults Completed NCT02126462 Phase 1
14 Safety and Immunogenicity Study of Na-GST-1 With or Without CpG Completed NCT02143518 Phase 1
15 Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy Adults Completed NCT01717950 Phase 1
16 Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant Completed NCT01385189 Phase 1
17 Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae Recruiting NCT01940757 Phase 1
18 Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults Recruiting NCT03373214 Phase 1
19 Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese Children Recruiting NCT02839161 Phase 1
20 Hookworm Therapy for Coeliac Disease Active, not recruiting NCT02754609 Phase 1
21 Phase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian Adults Terminated NCT00473967 Phase 1
22 Does Treating Hookworm Improve Productivity of Small Subsistence Farmers Unknown status NCT02102321 Not Applicable albendazole;placebo
23 Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Brazil Completed NCT00939198 Not Applicable
24 Randomised Controlled Clinical Trials of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis Completed NCT00232518 Not Applicable
25 Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar Completed NCT01869127 Not Applicable
26 Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma Completed NCT00469989 Not Applicable
27 Repeated Controlled Human Hookworm Infection Completed NCT03257072 Not Applicable
28 Development of a Skin Test for the Na-ASP-2 Hookworm Antigen Completed NCT00603889 Not Applicable
29 Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma Completed NCT01163877 Not Applicable
30 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
31 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
32 Immunisation, Treatment and Controlled Human Hookworm Infection Active, not recruiting NCT03702530 Not Applicable
33 Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center Active, not recruiting NCT03126552 Not Applicable
34 Hookworm Immune Regulation Project Active, not recruiting NCT02262403 Not Applicable

Search NIH Clinical Center for Ancylostomiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: ancylostomiasis

Genetic Tests for Ancylostomiasis

Anatomical Context for Ancylostomiasis

MalaCards organs/tissues related to Ancylostomiasis:

41
Skin, Eye, Small Intestine, Lung, Colon, Liver, Ovary

Publications for Ancylostomiasis

Articles related to Ancylostomiasis:

(show top 50) (show all 183)
# Title Authors Year
1
Correlation between hematological parameters and ancylostomiasis: A retrospective study. ( 30390342 )
2018
2
Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial. ( 29673735 )
2018
3
Prevalence of intestinal parasitic infections and associated risk factors for hookworm infections among primary schoolchildren in rural areas of Nakhon Si Thammarat, southern Thailand. ( 30217180 )
2018
4
Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial. ( 30496350 )
2018
5
Hookworm infections among migrant workers in Malaysia: Molecular identification of Necator americanus and Ancylostoma duodenale. ( 28610937 )
2017
6
The diversity and impact of hookworm infections in wildlife. ( 28765810 )
2017
7
Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya. ( 28863133 )
2017
8
Evaluation of the utility of conventional polymerase chain reaction for detection and species differentiation in human hookworm infections. ( 29114490 )
2017
9
Profiling Nonrecipients of Mass Drug Administration for Schistosomiasis and Hookworm Infections: A Comprehensive Analysis of Praziquantel and Albendazole Coverage in Community-Directed Treatment in Uganda. ( 26409064 )
2016
10
Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. ( 24515942 )
2014
11
High prevalence of Ancylostoma ceylanicum hookworm infections in humans, Cambodia, 2012. ( 24865815 )
2014
12
Prevalence of ancylostomiasis in people living in slum area, Philhousepet of Eluru, West Godavari District (Andhra Pradesh). ( 24431537 )
2013
13
Prednisolone and cyclosporine A: effects on an experimental model of ancylostomiasis. ( 23142084 )
2013
14
Comparison of real-time PCR and Kato smear microscopy for the detection of hookworm infections in three consecutive faecal samples from schoolchildren in Ghana. ( 23426113 )
2013
15
Impact of Plasmodium falciparum and hookworm infections on the frequency of anaemia in pregnant women of rural communities in Enugu, South East Nigeria. ( 23503560 )
2013
16
In vivo endoscopic imaging of ancylostomiasis-induced gastrointestinal bleeding: clinical and biological profiles. ( 22869629 )
2012
17
Intestinal ancylostomiasis: an unusual histologic finding. ( 22084430 )
2012
18
Molecular identification of human hookworm infections in economically disadvantaged communities in Peninsular Malaysia. ( 22556084 )
2012
19
Rapid detection and identification of human hookworm infections through high resolution melting (HRM) analysis. ( 22844538 )
2012
20
Evidence of microbial translocation associated with perturbations in T cell and antigen-presenting cell homeostasis in hookworm infections. ( 23056659 )
2012
21
Trichuris and hookworm infections associated with anaemia during pregnancy. ( 21281406 )
2011
22
The immunology of human hookworm infections. ( 20626810 )
2010
23
PCR-based coprodiagnostic tools reveal dogs as reservoirs of zoonotic ancylostomiasis caused by Ancylostoma ceylanicum in temple communities in Bangkok. ( 18556131 )
2008
24
Malaria and hookworm infections in relation to haemoglobin and serum ferritin levels in pregnancy in Masindi district, western Uganda. ( 17996912 )
2008
25
FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans. ( 18028969 )
2008
26
Hookworm infections in Singaporean soldiers after jungle training in Brunei Darussalam. ( 17919671 )
2007
27
Efficacy of mebendazole and albendazole for Ascaris lumbricoides and hookworm infections in an area with long time exposure for antihelminthes, Northwest Ethiopia. ( 18330331 )
2007
28
The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters. ( 16323144 )
2006
29
Distribution and clustering of Oesophagostomum bifurcum and hookworm infections in northern Ghana. ( 16388688 )
2006
30
Impact of repeated mass treatment on human Oesophagostomum and hookworm infections in northern Ghana. ( 17054758 )
2006
31
Liver phosphatases in mice treated with lead during murine ancylostomiasis. ( 15814320 )
2005
32
Anemia, malaria and hookworm infections in a Vietnamese ethnic minority. ( 16295531 )
2005
33
Hookworm infections in human and laboratory animals--differences and similarities in immune responses. ( 16913526 )
2005
34
The short-term impact of albendazole treatment on Oesophagostomum bifurcum and hookworm infections in northern Ghana. ( 15228719 )
2004
35
An epidemiological study of ancylostomiasis in a rural area of Kanpur district Uttar Pradesh, India. ( 15129854 )
2003
36
Random spatial distribution of Schistosoma mansoni and hookworm infections among school children within a single village. ( 14533674 )
2003
37
Effect of lead and ancylostomiasis on phosphatases of heart in Swiss albino mice. ( 12568465 )
2002
38
Reduction in the prevalence and intensity of hookworm infections after praziquantel treatment for schistosomiasis infection. ( 12062494 )
2002
39
Association between Schistosoma mansoni and hookworm infections among schoolchildren in Côte d'Ivoire. ( 12387908 )
2002
40
Hookworm infections of schoolchildren in southern Thailand. ( 12693578 )
2002
41
Epidemiology of Necator americanus hookworm infections in Xiulongkan Village, Hainan Province, China: high prevalence and intensity among middle-aged and elderly residents. ( 11534635 )
2001
42
Efficacy of DEC against Ascaris and hookworm infections in schoolchildren. ( 11555442 )
2001
43
Immune responses in hookworm infections. ( 11585781 )
2001
44
Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou Village), Anhui Province, China: II. Seroepidemiological studies of the age relationships of serum antibody levels and infection status. ( 11414422 )
2000
45
The epidemiology of human hookworm infections in the southern region of Mali. ( 10886798 )
2000
46
Epidemiology of human ancylostomiasis among rural villagers in Nanlin County (Zhongzhou village), Anhui Province, China: age-associated prevalence, intensity and hookworm species identification. ( 10928362 )
1999
47
Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa. ( 10450449 )
1999
48
Epidemiology of human hookworm infections among adult villagers in Hejiang and Santai Counties, Sichuan Province, China. ( 10546842 )
1999
49
Geographic distribution and epidemiology of Oesophagostomum bifurcum and hookworm infections in humans in Togo. ( 10674676 )
1999
50
Ancylostoma duodenale is responsible for hookworm infections among pregnant women in the rural plains of Nepal. ( 9645880 )
1998

Variations for Ancylostomiasis

Expression for Ancylostomiasis

Search GEO for disease gene expression data for Ancylostomiasis.

Pathways for Ancylostomiasis

Pathways related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 GCLC GCLM SERPINA1
2 10.64 GCLC GCLM
3 10.53 CP GCLC GCLM TF
4 10.13 GCLC GCLM

GO Terms for Ancylostomiasis

Cellular components related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate-cysteine ligase complex GO:0017109 8.62 GCLC GCLM

Biological processes related to Ancylostomiasis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.73 CP SERPINA1 TF
2 aging GO:0007568 9.72 GCLC GCLM MT-CO1
3 response to activity GO:0014823 9.58 GCLC GCLM
4 glutathione metabolic process GO:0006749 9.58 GCLC GCLM
5 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.57 GCLC GCLM
6 apoptotic mitochondrial changes GO:0008637 9.54 GCLC GCLM
7 glutamate metabolic process GO:0006536 9.52 GCLC GCLM
8 regulation of blood vessel size GO:0050880 9.51 GCLC GCLM
9 glutathione biosynthetic process GO:0006750 9.49 GCLC GCLM
10 cellular response to hepatocyte growth factor stimulus GO:0035729 9.48 GCLC GCLM
11 cellular response to follicle-stimulating hormone stimulus GO:0071372 9.46 GCLC GCLM
12 regulation of mitochondrial depolarization GO:0051900 9.43 GCLC GCLM
13 cellular response to fibroblast growth factor stimulus GO:0044344 9.43 EGR3 GCLC GCLM
14 cysteine metabolic process GO:0006534 9.4 GCLC GCLM
15 response to human chorionic gonadotropin GO:0044752 9.37 GCLC GCLM
16 response to nitrosative stress GO:0051409 9.32 GCLC GCLM
17 cellular response to thyroxine stimulus GO:0097069 9.16 GCLC GCLM
18 negative regulation of hepatic stellate cell activation GO:2000490 8.96 CYGB GCLC
19 response to oxidative stress GO:0006979 8.92 CYGB GCLC GCLM MT-CO1

Molecular functions related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamate-cysteine ligase activity GO:0004357 8.62 GCLC GCLM

Sources for Ancylostomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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