Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Ancylostomiasis

MalaCards integrated aliases for Ancylostomiasis:

Name: Ancylostomiasis 12 52 58 43 15 17 71 32
Hookworm Infections 54 71
Hookworm Infection 52 58
Ankylostomiasis 52 58
Ancylostomiasis Due to Ancylostoma Duodenale 71
Ancylostoma Duodenale Infection 52


Orphanet epidemiological data:

Inheritance: Not applicable; Age of onset: All ages;


Orphanet: 58  
Rare infectious diseases

External Ids:

Disease Ontology 12 DOID:12841
MeSH 43 D000724
NCIt 49 C35805
SNOMED-CT 67 63479002
ICD10 32 B76.0
MESH via Orphanet 44 D000724 D006725
ICD10 via Orphanet 33 B76.0 B76.1 B76.8 more
UMLS via Orphanet 72 C0002831 C0019911
Orphanet 58 ORPHA78
UMLS 71 C0002831 C0019911 C1384687

Summaries for Ancylostomiasis

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 78 Definition A hookworm infection caused primarily by the species Ancylostoma duodenale or Necator americanus , usually acquired through penetration of the skin, (often asymptomatic but that can also manifest with an allergic reaction at the site of skin penetration), followed by the migration of larva through the bloodstream to the lungs (causing asymptomatic pneumonitis, eosinophilia) and finally reaching and colonizing the small intestines where they cause blood extravasation leading to diarrhea, abdominal pain, and when untreated, melena, iron-deficiency anemia and protein malnutrition. Visit the Orphanet disease page for more resources.

MalaCards based summary : Ancylostomiasis, also known as hookworm infections, is related to filarial elephantiasis and parasitic helminthiasis infectious disease, and has symptoms including anemia, abdominal pain and intestinal bleeding. An important gene associated with Ancylostomiasis is EPGN (Epithelial Mitogen), and among its related pathways/superpathways are Post-translational modification- synthesis of GPI-anchored proteins and Folate biosynthesis. The drugs Albendazole and Pyrantel have been mentioned in the context of this disorder. Affiliated tissues include skin, small intestine and eye, and related phenotype is homeostasis/metabolism.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has symptom intestinal bleeding, has symptom abdominal pain, has symptom anemia, has symptom severe diarrhea and has symptom malnutrition.

Wikipedia : 74 Ancylostomiasis is a hookworm disease caused by infection with Ancylostoma hookworms. The name is... more...

Related Diseases for Ancylostomiasis

Diseases related to Ancylostomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 filarial elephantiasis 30.6 MT-CO1 EPGN
2 parasitic helminthiasis infectious disease 30.4 MT-CO1 EPGN
3 enterobiasis 30.2 MT-CO1 EPGN
4 strongyloidiasis 30.1 MT-CO1 EPGN
5 oesophagostomiasis 30.1 MT-CO1 EPGN
6 intestinal schistosomiasis 30.0 MT-CO1 EPGN
7 necatoriasis 30.0 MXRA8 MAGEH1 EPGN
8 ascaridiasis 10.6
9 ascaris lumbricoides infection 10.6
10 deficiency anemia 10.6
11 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.5
12 schistosoma mansoni infection, susceptibility/ 10.3
13 schistosomiasis 10.3
14 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.3
15 duodenal ulcer 10.3
16 hypereosinophilic syndrome 10.3
17 trichuriasis 10.2
18 iron metabolism disease 10.2
19 celiac disease 1 10.2
20 colitis 10.1
21 autoimmune disease 10.1
22 allergic asthma 10.1
23 paragonimiasis 10.1 MT-CO1 EPGN
24 mycobacterium tuberculosis 1 10.1
25 malaria 10.1
26 taeniasis 10.1
27 cysticercosis 10.1
28 filariasis 10.1
29 iron deficiency anemia 10.1
30 allergic hypersensitivity disease 10.1
31 amebiasis 10.1
32 clonorchiasis 10.1 MT-CO1 EPGN
33 alveolar soft part sarcoma 10.1
34 exanthem 10.1
35 protein-energy malnutrition 10.1
36 nephrotic syndrome 10.1
37 opisthorchiasis 10.1
38 pulmonary embolism 10.1
39 47,xyy 10.1
40 cutaneous larva migrans 10.1
41 fascioliasis 10.0 MT-CO1 EPGN
42 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
43 leprosy 3 10.0
44 sickle cell anemia 10.0
45 salmonellosis 10.0
46 trypanosomiasis 10.0
47 rabies 10.0
48 panuveitis 10.0
49 chagas disease 10.0
50 neutropenia 10.0

Graphical network of the top 20 diseases related to Ancylostomiasis:

Diseases related to Ancylostomiasis

Symptoms & Phenotypes for Ancylostomiasis


  • anemia
  • abdominal pain
  • intestinal bleeding
  • malnutrition
  • severe diarrhea

MGI Mouse Phenotypes related to Ancylostomiasis:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 ALPI ASPA EGR3 EPGN HHAT MT-CO1

Drugs & Therapeutics for Ancylostomiasis

Drugs for Ancylostomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
3 Oxantel Experimental Phase 4 36531-26-7
4 Antiprotozoal Agents Phase 4
5 Neuromuscular Blocking Agents Phase 4
6 Pyrantel Pamoate Phase 4
Oxantel pamoate Phase 4 68813-55-8 5281086
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
11 Cayenne Phase 2
12 Antacids Phase 2
13 Vaccines Phase 2
14 Adjuvants, Immunologic Phase 2
15 Anti-Ulcer Agents Phase 2
16 Gastrointestinal Agents Phase 2
17 Immunologic Factors Phase 2
18 Milbemycin Phase 2
Iron Approved, Experimental Phase 1 15438-31-0, 7439-89-6 27284 23925
Ferrous fumarate Approved Phase 1 141-01-5
Imidazole Experimental, Investigational Phase 1 288-32-4 795
22 Monophosphoryl lipid A Phase 1
23 interferons Phase 1
24 Interferon-gamma Phase 1
25 CPG-oligonucleotide Phase 1
26 Interleukin-12 Phase 1
27 Trace Elements Phase 1
28 Iron Supplement Phase 1
29 Nutrients Phase 1
30 Micronutrients Phase 1
leucovorin Approved 58-05-9 6006 143
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
33 Vitamin B Complex
34 Folate
35 Vitamin B9

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Different Drug Combinations Against Hookworm Infection in School-aged Children in the Lao People's Democratic Republic, a Single Blind, Randomised Controlled Trial Completed NCT03278431 Phase 4 Albendazole;Pyrantel Pamoate;Oxantel Pamoate;Mebendazole
2 Efficacy and Safety of a Single-dose Regimen and a Multi-dose Regimen of Mebendazole Against Hookworm Infections in School Children: a Randomized Controlled Trial Completed NCT03245398 Phase 4 Treatment with one of the two regimens of mebendazole
3 The Impact of Different Treatment Strategies on the Transmission Dynamics of Soil-transmitted Helminths: a Cluster Randomised Trial in Kenya Completed NCT02397772 Phase 4 albendazole
4 Efficacy and Safety of a Single-dose Regimen and a Multi-dose Regimen of Mebendazole Against Hookworm Infections in Children and Adolescents in Ghana: a Randomized Controlled Trial Withdrawn NCT03261596 Phase 4 Mebendazole
5 Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections Completed NCT01350271 Phase 3 Mebendazole polymorph A and C 500 mg;Mebendazole polymorph C;Placebo
6 Efficacy and Safety of a New Chewable Tablet of Mebendazole Versus the Swallowable, Standard Tablet of Mebendazole Against Hookworm Infections in Children: a Randomized Controlled Trial Completed NCT03995680 Phase 2 Mebendazole
7 A Phase 2a, Randomized, Double Blinded, Placebo Controlled, Study Evaluating Immunity and Gluten-sensitivity by Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus. Completed NCT00671138 Phase 2
8 Phase 2 Study to Assess the Safety, Efficacy and Immunogenicity of Na-GST-1/Alhydrogel Co-administered With Different Toll-Like Receptor Agonists in Hookworm- Naïve Adults Recruiting NCT03172975 Phase 2 Albendazole
9 Efficacy and Safety of Ascending Dosages of Albendazole Against T. Trichiura and Hookworm in Preschool- and School-aged Children and Adults: a Randomized Controlled Trial Active, not recruiting NCT03527745 Phase 2 Albendazole;Albendazole;Albendazole;Albendazole;Placebo
10 Efficacy, Safety and Pharmacokinetics of Ascending Dosages of Moxidectin Alone and in Comparison to Ivermectin Against Strongyloidiasis Stercoralis in Adults: a Randomized Controlled Trial Enrolling by invitation NCT04056325 Phase 2 Moxidectin;Ivermectin;Placebo oral tablet
11 Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis. Withdrawn NCT00630383 Phase 2
12 Phase 1, Single-Center, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study to Compare the Safety, Tolerability, and Immunogenicity of Three Intramuscular Administrations of Na-ASP-2 Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm Infection Completed NCT00120081 Phase 1
13 Phase 1 Study of the Safety and Immunogenicity of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel® in Brazilian Adults Completed NCT02476773 Phase 1
14 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Co-administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 Adjuvanted With Alhydrogel® and Gluco-pyranosylphospho-lipid A in Gabonese Adults Completed NCT02126462 Phase 1
15 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Na-GST-1/Alhydrogel®, With or Without a CPG ODN Adjuvant, in Gabonese Adults Completed NCT03373214 Phase 1
16 Phase 1 Study of the Safety and Immunogenicity of Na-APR-1 (M74)/Alhydrogel® in Healthy Adults Completed NCT01717950 Phase 1
17 Phase 1 Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel, With or Without a CpG ODN Adjuvant, in Healthy Adults Completed NCT02143518 Phase 1
18 Phase I Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel® With Different Doses of the Novel Immunostimulant GLA-AF in Healthy Adults Completed NCT01385189 Phase 1
19 Phase 1 Study of the Safety and Immunogenicity of Na-GST-1/Alhydrogel® With or Without GLA-AF in Brazilian Adults Completed NCT01261130 Phase 1
20 Hookworm Therapy for Coeliac Disease: A Phase 1B Safety and Dose-ranging Clinical Trial Examining Sustained Gluten Consumption in Hookworm-naive and Hookworm-infection People With Coeliac Disease Completed NCT02754609 Phase 1
21 Randomized, Controlled, Phase 1 Study to Assess Safety and Immunogenicity of Co-administered Hookworm Vaccine Candidates Na-APR-1 (M74)/Alhydrogel® and Na-GST-1/ Alhydrogel® in Gabonese Children Completed NCT02839161 Phase 1
22 The Usefulness of Ferrous Fumarate and Ferric Pyrophosphate as Food Fortificants in Developing Countries Completed NCT00867867 Phase 1 Ferrous fumarate;Ferric pyrophosphate;Placebo
23 An Experimental Infection Study of Dermally-applied Infectious Necator Americanus Hookworm Larvae in Hookworm-naïve Adults Recruiting NCT01940757 Phase 1
24 Double-blind, Randomized, Controlled Phase 1 Study of the Safety and Immunogenicity of Na-ASP-2 Hookworm Vaccine in Previously-Infected Brazilian Adults Terminated NCT00473967 Phase 1
25 A Randomized Effectiveness Trial of Hookworm Treatment of Women Smallholder Farmers to Evaluate Improved Productivity of Their Farming and/or Household Labor Unknown status NCT02102321 albendazole;placebo
26 Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma. Completed NCT01163877
27 Immunisation, Treatment and Controlled Human Hookworm Infection Completed NCT03702530
28 Randomised Controlled Clinical Trial of the Effect of Therapeutic Hookworm Infection in Allergic Rhinoconjunctivitis Completed NCT00232518
29 Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in Asthma Completed NCT00469989
30 Repeated Controlled Human Hookworm Infection in Healthy Dutch Volunteers Completed NCT03257072
31 Determination of Prevalence and Intensity of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of Northeastern Minas Gerais, Brazil Completed NCT00939198
32 Development of a Skin Test to Detect Immediate-type Hypersensitivity to the Experimental Na-ASP-2 Hookworm Antigen Completed NCT00603889
33 Shoes for Kids on the Island of Pemba (SKIP): A Pragmatic, Cluster Randomised Controlled Trial to Test if Shoes Reduce Hookworm Infection and Transmission in School-aged Children on Pemba Island, Zanzibar Completed NCT01869127
34 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
35 Assessment of Drug Efficacy of Albendazole Bought on Local Market Against Soil-transmitted Helminth Infections in School Children in Jimma, Ethiopia Completed NCT02420574 albendazole BENDEX;albendazole OVIS
36 Effects of Video-based Health Education on Health Status of Pregnant Mothers and Their Infants (From 0 to 6 Months) in Dirashe District Southern Ethiopia - a Cluster Randomized Controlled Trial. Recruiting NCT04414527
37 Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection Active, not recruiting NCT02262403
38 Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center Active, not recruiting NCT03126552
39 Re-infection Rates of Soil-transmitted Helminth Infections Among School-aged Children Following a Single or a 4-monthly Health Hygiene Education: an Open Label Clinical Trial Active, not recruiting NCT04227834

Search NIH Clinical Center for Ancylostomiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Pyrantel Pamoate

Cochrane evidence based reviews: ancylostomiasis

Genetic Tests for Ancylostomiasis

Anatomical Context for Ancylostomiasis

MalaCards organs/tissues related to Ancylostomiasis:

Skin, Small Intestine, Eye, Colon, Lung, Testes, Heart

Publications for Ancylostomiasis

Articles related to Ancylostomiasis:

(show top 50) (show all 852)
# Title Authors PMID Year
The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo. 61
32574160 2020
High-throughput multiplex qPCRs for the surveillance of zoonotic species of canine hookworms. 61
32542036 2020
A holistic approach is needed to control the perpetual burden of soil-transmitted helminth infections among indigenous schoolchildren in Malaysia. 61
32249689 2020
Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial. 61
32460712 2020
Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation. 61
32238181 2020
Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis. 61
32342850 2020
Efficacy of Simparica Trio™, a novel chewable tablet containing sarolaner, moxidectin and pyrantel, against induced hookworm infections in dogs. 61
32113471 2020
Insights into hookworm prevalence in Asia: a systematic review and meta-analysis. 61
31917423 2020
Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya. 61
32351578 2020
[Investigation on human hookworm infections in Anhui Province from 2014 to 2015]. 61
32185934 2020
Distribution of ascariasis, trichuriasis and hookworm infections in Ogun State, Southwestern Nigeria. 61
32511237 2020
Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? 61
31818311 2019
Sustained preventive chemotherapy for soil-transmitted helminthiases leads to reduction in prevalence and anthelminthic tablets required. 61
31575378 2019
[Progress of research on host immune responses induced by hookworm infection and its potential therapeutic values]. 61
31713396 2019
Hookworm infection aggravates metabolic disorder in obesity. 61
31306675 2019
A Half-Century Studies on Epidemiological Features of Ancylostomiasis in China: A Review Article. 61
31700811 2019
Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16. 61
31486912 2019
A Case of Cutaneous Larva Migrans in a Child from Vinces, Ecuador. 61
31543509 2019
New Insights Into the Kinetics and Variability of Egg Excretion in Controlled Human Hookworm Infections. 61
31077279 2019
Efficacy and Safety of Ascending Dosages of Tribendimidine Against Hookworm Infections in Children: A Randomized Controlled Trial. 61
30496350 2019
HLA-G expression during hookworm infection in pregnant women. 61
31078470 2019
Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control. 61
30648601 2019
Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters. 61
31133690 2019
A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection. 61
31009474 2019
Correlation between hematological parameters and ancylostomiasis: A retrospective study. 61
30390342 2019
30946305 2019
Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. 61
28711437 2019
Modified Harada-Mori and simple wet mount to determine hookworm infections in Yo Island urban area, Songkhla, Southern Thailand. 61
31049017 2019
Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study. 61
30589847 2018
Epidemiology of viral hepatitis in Somalia: Systematic review and meta-analysis study. 61
30228786 2018
Prevalence of intestinal parasitic infections and associated risk factors for hookworm infections among primary schoolchildren in rural areas of Nakhon Si Thammarat, southern Thailand. 61
30217180 2018
Soil-transmitted helminth infections, anemia and undernutrition among schoolchildren in Yirgacheffee, South Ethiopia. 61
30103797 2018
Immunochromatographic test for rapid serological diagnosis of human angiostrongyliasis. 61
29908250 2018
Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. 61
29772478 2018
Epidemiology of soil transmitted Helminth infections in the middle-belt of Ghana, Africa. 61
29988303 2018
Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial. 61
29673735 2018
Efficacy and Safety of a Single Dose versus a Multiple Dose Regimen of Mebendazole against Hookworm Infections in Children: A Randomised, Double-blind Trial. 61
31193620 2018
Concurrent Infection of a Young Tourist by Hookworm and Strongyloides Stercoralis During Low Budget Travel in Southeast Asia. 61
31662643 2018
In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. 61
29775454 2018
Diagnostic value of OMOM capsule endoscopy for small bowel diseases in adults. 61
29545870 2018
Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis. 61
29702653 2018
[Surveillance of soil-borne nematodiasis in population in Hefei City, 2012-2015]. 61
29770668 2018
Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia - A systematic review. 61
29346440 2018
Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review. 61
29382360 2018
Sero-detection of Toxocara canis infection in human with T.canis recombinant arginine kinase, cathepsin L-1 and TES-26 antigens. 61
29035863 2017
The diversity and impact of hookworm infections in wildlife. 61
28765810 2017
The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus. 61
29261231 2017
Comparison between merthiolate-iodine-formalin and Kato-Katz methods for the diagnosis of human helminth infections in resource-limited settings. 61
27790963 2017
Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study. 61
28991899 2017
Poverty, Dietary Intake, Intestinal Parasites, and Nutritional Status among School-Age Children in the Rural Philippines. 61
30270906 2017

Variations for Ancylostomiasis

Expression for Ancylostomiasis

Search GEO for disease gene expression data for Ancylostomiasis.

Pathways for Ancylostomiasis

Pathways related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
3 9.83 ALPI ALPG

GO Terms for Ancylostomiasis

Molecular functions related to Ancylostomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 8.62 ALPI ALPG

Sources for Ancylostomiasis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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