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MCID: ANM038
MIFTS: 59

Anemia, Autoimmune Hemolytic

Categories: Rare diseases, Immune diseases, Genetic diseases, Blood diseases, Metabolic diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anemia, Autoimmune Hemolytic

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MalaCards integrated aliases for Anemia, Autoimmune Hemolytic:

Name: Anemia, Autoimmune Hemolytic 57
Autoimmune Hemolytic Anemia 12 76 53 37 29 55 15 73
Idiopathic Autoimmune Hemolytic Anemia 53 73
Immuno-Hemolytic Anemia 53 73
Familial Auto-Immune Hemolytic Anemia 53
Acquired Autoimmune Hemolytic Anemia 53
Autoimmune Haemolytic Anaemia 12
Anemia, Hemolytic, Autoimmune 44
Anemia Hemolytic Autoimmune 53

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
anemia, autoimmune hemolytic:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Metabolic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Anemia, Autoimmune Hemolytic

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NIH Rare Diseases : 53 Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions.

MalaCards based summary : Anemia, Autoimmune Hemolytic, also known as autoimmune hemolytic anemia, is related to evans' syndrome and hemolytic anemia. An important gene associated with Anemia, Autoimmune Hemolytic is HP (Haptoglobin), and among its related pathways/superpathways are Innate Immune System and Creation of C4 and C2 activators. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and b cells, and related phenotypes are autoimmune hemolytic anemia and abnormality of metabolism/homeostasis

Disease Ontology : 12 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia : 76 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM: 205700
Sources

Related Diseases for Anemia, Autoimmune Hemolytic

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Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Anemia, Autoimmune Hemolytic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 evans' syndrome 33.7 CD40LG HP
2 hemolytic anemia 31.4 CD55 CD59 HP
3 drug-induced autoimmune hemolytic anemia 12.5
4 mixed-type autoimmune hemolytic anemia 12.3
5 autoimmune hemolytic anemia, warm type 12.3
6 lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmune hemolytic anemia, and glomerulonephritis 12.1
7 neonatal autoimmune hemolytic anemia 12.1
8 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 12.1
9 warm antibody hemolytic anemia 12.1
10 cold agglutinin disease 11.5
11 purine nucleoside phosphorylase deficiency 11.3
12 selective igg deficiency disease 10.8 CD40LG CD79A
13 c1q nephropathy 10.8 CD40LG CD79A
14 meningovascular neurosyphilis 10.8 CD40LG CD79A
15 alpha chain disease 10.8 CD40LG CD79A
16 brill-zinsser disease 10.8 CD40LG CD79A
17 exudative glomerulonephritis 10.8 CD40LG CD79A
18 cork-handlers' disease 10.8 CD40LG CD79A
19 salpingo-oophoritis 10.8 CD40LG CD79A
20 early yaws 10.8 CD40LG CD79A
21 ventilation pneumonitis 10.8 CD40LG CD79A
22 chronic interstitial cystitis 10.8 CD40LG CD79A
23 axillary adenitis 10.8 CD40LG CD79A
24 trichostrongyloidiasis 10.8 CD40LG CD79A
25 subacute bacterial endocarditis 10.8 CD40LG CD79A
26 heterophyiasis 10.8 CD40LG CD79A
27 immunoglobulin g deficiency 10.8 CD40LG CD79A
28 orbital granuloma 10.8 CD40LG CD79A
29 transient hypogammaglobulinemia of infancy 10.8 CD40LG CD79A
30 hyperglobulinemic purpura 10.8 CD40LG CD79A
31 gastroduodenitis 10.8 CD40LG CD79A
32 bacterial conjunctivitis 10.8 CD40LG CD79A
33 heavy chain disease 10.8 CD40LG CD79A
34 ophthalmia neonatorum 10.8 CD40LG CD79A
35 immunoglobulin a deficiency 1 10.8 CD40LG CD79A
36 parotid disease 10.8 CD40LG CD79A
37 cerebral arteritis 10.8 CD40LG CD79A
38 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
39 multiple congenital anomalies-hypotonia-seizures syndrome 2 10.8 CD55 CD59
40 erythema elevatum diutinum 10.8 CD40LG CD79A
41 sporotrichosis 10.8 CD40LG CD79A
42 fallopian tube disease 10.8 CD40LG CD79A
43 hyperimmunoglobulin syndrome 10.8 CD40LG CD79A
44 congenital syphilis 10.8 CD40LG CD79A
45 polyclonal hypergammaglobulinemia 10.8 CD40LG CD79A
46 monoclonal paraproteinemia 10.8 CD40LG CD79A
47 salpingitis 10.8 CD40LG CD79A
48 ocular toxoplasmosis 10.8 CD40LG CD79A
49 dysgammaglobulinemia 10.8 CD40LG CD79A
50 congenital hypogammaglobulinemia 10.8 CD40LG CD79A

Comorbidity relations with Anemia, Autoimmune Hemolytic via Phenotypic Disease Network (PDN):


Acquired Thrombocytopenia Acute Cystitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Leukemia, Chronic Lymphocytic
Neutropenia

Graphical network of the top 20 diseases related to Anemia, Autoimmune Hemolytic:



Diseases related to Anemia, Autoimmune Hemolytic
Sources

Symptoms & Phenotypes for Anemia, Autoimmune Hemolytic

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Symptoms via clinical synopsis from OMIM:

57
Heme:
autoimmune hemolytic anemia

Lab:
coombs positive
abnormal immunoglobulin in heterozygotes


Clinical features from OMIM:

205700

Human phenotypes related to Anemia, Autoimmune Hemolytic:

32 (show all 18)
# Description HPO Frequency HPO Source Accession
1 autoimmune hemolytic anemia 32 HP:0001890
2 abnormality of metabolism/homeostasis 32 HP:0001939
3 pallor 32 frequent (33%) HP:0000980
4 muscle weakness 32 hallmark (90%) HP:0001324
5 congestive heart failure 32 occasional (7.5%) HP:0001635
6 splenomegaly 32 occasional (7.5%) HP:0001744
7 hemolytic anemia 32 hallmark (90%) HP:0001878
8 abnormal leukocyte morphology 32 hallmark (90%) HP:0001881
9 fever 32 occasional (7.5%) HP:0001945
10 abdominal pain 32 occasional (7.5%) HP:0002027
11 dyspnea 32 hallmark (90%) HP:0002094
12 headache 32 hallmark (90%) HP:0002315
13 lymphoma 32 frequent (33%) HP:0002665
14 immunodeficiency 32 frequent (33%) HP:0002721
15 autoimmunity 32 hallmark (90%) HP:0002960
16 arrhythmia 32 occasional (7.5%) HP:0011675
17 abnormal urinary color 32 occasional (7.5%) HP:0012086
18 fatigue 32 hallmark (90%) HP:0012378

MGI Mouse Phenotypes related to Anemia, Autoimmune Hemolytic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 RHD SIRPA C3 CD40LG CD5 CD55
Sources

Drugs & Therapeutics for Anemia, Autoimmune Hemolytic

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Drugs for Anemia, Autoimmune Hemolytic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-24-8 5755
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
4
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
5
Fludarabine Approved Phase 3,Phase 2 21679-14-1, 75607-67-9 30751
6
Vidarabine Approved, Investigational Phase 3,Phase 2 24356-66-9 32326 21704
7
Chlorambucil Approved Phase 3,Phase 2 305-03-3 2708
8 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
9 Antibodies Phase 3,Phase 2
10 Antiemetics Phase 3,Phase 2,Not Applicable
11 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
12 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
13 Autonomic Agents Phase 3,Phase 2,Not Applicable
14 Gastrointestinal Agents Phase 3,Phase 2,Not Applicable
15 glucocorticoids Phase 3,Phase 2,Not Applicable
16 Hormone Antagonists Phase 3,Phase 2,Not Applicable
17 Hormones Phase 3,Phase 2,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
19 Immunoglobulins Phase 3,Phase 2
20 Methylprednisolone acetate Phase 3,Phase 2,Not Applicable
21 Methylprednisolone Hemisuccinate Phase 3,Phase 2,Not Applicable
22 Neuroprotective Agents Phase 3,Phase 2,Not Applicable
23 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
24 Prednisolone acetate Phase 3,Phase 2,Not Applicable
25 Prednisolone hemisuccinate Phase 3,Phase 2,Not Applicable
26 Prednisolone phosphate Phase 3,Phase 2,Not Applicable
27 Protective Agents Phase 3,Phase 2,Not Applicable
28 Alkylating Agents Phase 3,Phase 2,Not Applicable
29 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
30 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
31 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
32 Antibodies, Monoclonal Phase 3,Phase 2
33 Antimetabolites Phase 3,Phase 2
34 Antimetabolites, Antineoplastic Phase 3,Phase 2
35 Antiviral Agents Phase 3,Phase 2,Phase 1
36
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
37
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
38
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
39
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
40
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
41
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
42
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
43
alemtuzumab Approved, Investigational Phase 2 216503-57-0
44
Doxil Approved June 1999 Phase 2 31703
45
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
46 Adjuvants, Immunologic Phase 2
47 Anthelmintics Phase 2
48 Antiparasitic Agents Phase 2
49 Autoantibodies Phase 2
50 Anti-Bacterial Agents Phase 2

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Rituximab in Auto-Immune Hemolytic Anemia Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
2 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
3 Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia Completed NCT00824265 Phase 3 OFC Infusion;FC infusion
4 Ofatumumab vs Physician's Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia Completed NCT01313689 Phase 3 Ofatumumab;Physicians' Choice
5 Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia Active, not recruiting NCT00748189 Phase 3 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
6 Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy Active, not recruiting NCT01039376 Phase 3
7 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
8 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
9 Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
10 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2 Bendamustine, Rituximab
11 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2 Rituximab;Fludarabine
12 Bortezomib to Treat Significant Complication of HSCT Completed NCT01929980 Phase 2 Bortezomib
13 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2 cyclophosphamide;filgrastim
14 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
15 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
16 A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia Completed NCT01563055 Phase 2 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
17 A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) Recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
18 Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With wAIHA or CAD Recruiting NCT03226678 Phase 2 APL-2
19 Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Recruiting NCT02389231 Phase 1, Phase 2 Interleukine-2
20 A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia Not yet recruiting NCT03538041 Phase 2 INCB050465
21 The Efficacy and Safety of Alemtuzumab in Auotoimmune Cytopenias Terminated NCT00472433 Phase 2 Alemtuzumab
22 Treatment of Autoimmune Thrombocytopenia (AITP) Completed NCT00001630 Phase 1
23 A Safety Study of SYNT001 in Subjects With Chronic, Stable Warm Autoimmune Hemolytic Anemia (WAIHA) Recruiting NCT03075878 Phase 1 SYNT001
24 Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1 TNT009
25 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
26 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219
27 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
28 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
29 Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA) Recruiting NCT02828670
30 Immunopathology of Autoimmune Hemolytic Anemia Recruiting NCT02158195
31 Autoimmune Cytopenias : Midi-Pyrenees Registry Recruiting NCT02877706
32 Severe Immune Cytopenia Registry Www.Sic-reg.Org Recruiting NCT03576742
33 One Year Hospital Data Patients With AIHA in Assiut University Hospital - Clinical Hematology Unit Not yet recruiting NCT03269292
34 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805

Search NIH Clinical Center for Anemia, Autoimmune Hemolytic

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: anemia, hemolytic, autoimmune

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Genetic Tests for Anemia, Autoimmune Hemolytic

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Genetic tests related to Anemia, Autoimmune Hemolytic:

# Genetic test Affiliating Genes
1 Autoimmune Hemolytic Anemia 29
Sources

Anatomical Context for Anemia, Autoimmune Hemolytic

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MalaCards organs/tissues related to Anemia, Autoimmune Hemolytic:

41
Testes, T Cells, B Cells, Liver, Bone, Heart, Bone Marrow
Sources

Publications for Anemia, Autoimmune Hemolytic

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Articles related to Anemia, Autoimmune Hemolytic:

(show top 50) (show all 718)
# Title Authors Year
1
Exacerbation of autoimmune hemolytic anemia induced by the first dose of programmed death-1 inhibitor pembrolizumab: a case report. ( 29340837 )
2018
2
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
3
Mixed IgM cold and IgG warm autoimmune hemolytic anemia complicated by acral gangrene. ( 29683507 )
2018
4
Ominous comorbidities: Small ventricular septal defect and warm autoimmune hemolytic anemia. ( 29440848 )
2018
5
Splenic myeloid metaplasia in warm autoimmune hemolytic anemia (wAIHA): a retrospective study. ( 29662860 )
2018
6
Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis. ( 29359617 )
2018
7
Eluate testing with monospecific antisera unmasks multiple immunoglobulin classes and identifies frequent IgA involvement in severe autoimmune hemolytic anemia. ( 29716828 )
2018
8
Features of peripheral CD8<sup>+</sup>CD57<sup>+</sup> lymphocytes in patients with autoimmune hemolytic anemia. ( 29845877 )
2018
9
Efficacy of D- red blood cell transfusion and rituximab therapy in autoimmune hemolytic anemia with anti-D and panreactive autoantibodies arising after hematopoietic stem cell transplant. ( 29664112 )
2018
10
Durable responses in refractory autoimmune hemolytic anemia with alemtuzumab. ( 29334337 )
2018
11
Predictors of refractoriness to therapy and healthcare resource utilization in 378 patients with primary autoimmune hemolytic anemia from 8 Italian Reference Centers. ( 29981267 )
2018
12
Should Giant Cell Hepatitis With Autoimmune Hemolytic Anemia Be Considered a Pediatric Autoimmune Liver Disease? ( 29394216 )
2018
13
An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report. ( 28700492 )
2017
14
Treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma presenting simultaneously with acquired hemophilia and warm autoimmune hemolytic anemia. ( 28670081 )
2017
15
Tumor necrosis factor gene polymorphisms in adult patients with autoimmune hemolytic anemia. ( 28111935 )
2017
16
Successful treatment of tacrolimus-related pure red cell aplasia and autoimmune hemolytic anemia with rituximab in a pediatric cardiac transplant patient. ( 28598573 )
2017
17
Steroid-Refractory Autoimmune Hemolytic Anemia with Massive Splenomegaly. ( 28389309 )
2017
18
Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City. ( 28401101 )
2017
19
Reliable assessment of the incidence of childhood autoimmune hemolytic anemia. ( 28748541 )
2017
20
Autoimmune Hemolytic Anemia in Plasmodium vivax Malaria. ( 28290054 )
2017
21
Thyroid storm and warm autoimmune hemolytic anemia. ( 28870408 )
2017
22
Rituximab in refractory autoimmune hemolytic anemia in systemic lupus erythematosus. ( 28870533 )
2017
23
Autoimmune hemolytic anemia associated with trimethoprim-sulfamethoxazole use. ( 28596226 )
2017
24
C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. ( 29277896 )
2017
25
How I treat autoimmune hemolytic anemia. ( 28360039 )
2017
26
Plasmapheresis in a child with cold antibody autoimmune hemolytic anemia: case report. ( 29062252 )
2017
27
Autoimmune Hemolytic Anemia. ( 28189175 )
2017
28
Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p). ( 28597168 )
2017
29
A rare case of autoimmune hemolytic anemia. ( 28751361 )
2017
30
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )
2017
31
Platelet satellitism in autoimmune hemolytic anemia. ( 28619392 )
2017
32
Human Immunodeficiency Virus Infection Increases the Risk of Incident Autoimmune Hemolytic Anemia: A Population-Based Cohort Study in Taiwan. ( 29149339 )
2017
33
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
34
Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report. ( 28878911 )
2017
35
Therapeutic plasma exchange in refractory warm autoimmune hemolytic anemia. ( 28594138 )
2017
36
A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication. ( 28948030 )
2017
37
Prognostic impact of bone marrow fibrosis and dyserythropoiesis in autoimmune hemolytic anemia. ( 29274091 )
2017
38
High prevalence of monoclonal gammopathy among patients with warm autoimmune hemolytic anemia. ( 28437873 )
2017
39
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice. ( 28455817 )
2017
40
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
41
Autoimmune hemolytic anemia in solid organ transplantation-The role of immunosuppression. ( 28621877 )
2017
42
No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. ( 27082039 )
2016
43
Systemic lupus erythematosus presenting with mixed-type fulminant autoimmune hemolytic anemia. ( 26892457 )
2016
44
AOHE: manuscript AOHE-D-16-00564 paroxysmal nocturnal hemoglobinuria with autoimmune hemolytic anemia following eculizumab therapy-with large granular lymphocytic leukemia. ( 27449072 )
2016
45
Diagnosis and treatment of autoimmune hemolytic anemia: classic approach and recent advances. ( 27382547 )
2016
46
Autoimmune Hemolytic Anemia Triggered by Infection with Human Parvovirus B19 after Total Abdominal Colectomy for Ulcerative Colitis. ( 26984090 )
2016
47
Fatal warm autoimmune hemolytic anemia in a child due to IgM-type autoantibodies. ( 27273179 )
2016
48
Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. ( 27062564 )
2016
49
Refractory IgG Warm Autoimmune Hemolytic Anemia Treated with Eculizumab: A Novel Application of Anticomplement Therapy. ( 27092282 )
2016
50
Autoimmune Hemolytic Anemia in Individuals Aged 75 and Older: A Study of 10 Individuals. ( 27321629 )
2016
Sources

Variations for Anemia, Autoimmune Hemolytic

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Expression for Anemia, Autoimmune Hemolytic

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Search GEO for disease gene expression data for Anemia, Autoimmune Hemolytic.
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Pathways for Anemia, Autoimmune Hemolytic

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Pathways related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.6 C1S C3 CD40LG CD55 CD59 CD79A
2
Creation of C4 and C2 activators 66
Show member pathways
 11.83 C1S C3 CD55 CD59
3
Complement and coagulation cascades 1 37
11.77 C1S C3 CD55 CD59
4
Immune response Lectin induced complement pathway 22
Show member pathways
 11.68 C1S C3 CD55 CD59
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.52 CD5 CD59 CD79A GYPA
6
Complement Pathway 64
Show member pathways
 11.28 C1S C3 CD55 CD59
7
Primary immunodeficiency 37
11 CD40LG CD79A
8
Hematopoietic cell lineage 37
10.91 CD5 CD55 CD59 GYPA
Sources

GO Terms for Anemia, Autoimmune Hemolytic

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Cellular components related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 C1S C3 CD55 CD59 GYPA HP
2 blood microparticle GO:0072562 9.13 C1S C3 HP
3 integral component of plasma membrane GO:0005887 9.1 CD40LG CD5 CD55 CD79A RHCE RHD

Biological processes related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.71 C1S C3 CD55 CD79A
2 complement activation, classical pathway GO:0006958 9.54 C1S C3 CD55
3 positive regulation of phagocytosis GO:0050766 9.46 C3 SIRPA
4 B cell proliferation GO:0042100 9.43 CD40LG CD79A
5 neutrophil degranulation GO:0043312 9.35 C3 CD55 CD59 HP SIRPA
6 organic cation transport GO:0015695 9.32 RHCE RHD
7 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
8 ammonium transport GO:0015696 9.16 RHCE RHD
9 regulation of complement activation GO:0030449 8.92 C1S C3 CD55 CD59

Molecular functions related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ammonium transmembrane transporter activity GO:0008519 8.62 RHCE RHD
Sources

Sources for Anemia, Autoimmune Hemolytic

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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