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MCID: ANM038
MIFTS: 61

Anemia, Autoimmune Hemolytic

Categories: Blood diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anemia, Autoimmune Hemolytic

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MalaCards integrated aliases for Anemia, Autoimmune Hemolytic:

Name: Anemia, Autoimmune Hemolytic 57
Autoimmune Hemolytic Anemia 12 76 53 37 29 55 15 73
Idiopathic Autoimmune Hemolytic Anemia 53 73
Immuno-Hemolytic Anemia 53 73
Familial Auto-Immune Hemolytic Anemia 53
Acquired Autoimmune Hemolytic Anemia 53
Autoimmune Haemolytic Anaemia 12
Anemia, Hemolytic, Autoimmune 44
Anemia Hemolytic Autoimmune 53

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
anemia, autoimmune hemolytic:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Anemia, Autoimmune Hemolytic

About this section
NIH Rare Diseases : 53 Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions.

MalaCards based summary : Anemia, Autoimmune Hemolytic, also known as autoimmune hemolytic anemia, is related to hemolytic anemia and lupus erythematosus. An important gene associated with Anemia, Autoimmune Hemolytic is HP (Haptoglobin), and among its related pathways/superpathways are Innate Immune System and Toxoplasmosis. The drugs Prednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, b cells and t cells, and related phenotypes are muscle weakness and splenomegaly

Disease Ontology : 12 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia : 76 Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person''s own red blood... more...

Description from OMIM: 205700
Sources

Related Diseases for Anemia, Autoimmune Hemolytic

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Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Anemia, Autoimmune Hemolytic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 hemolytic anemia 31.1 C3 CD55 CD59 HP
2 lupus erythematosus 30.6 C1S C3 CD40LG
3 glomerulonephritis 30.3 C1S C3 CD40LG
4 paroxysmal nocturnal hemoglobinuria 30.2 CD55 CD59 HP
5 hemoglobinuria 30.1 C3 CD55 CD59 HP
6 immunoglobulin alpha deficiency 30.0 CD40LG HP
7 systemic lupus erythematosus 30.0 C1S C3 CD40LG CD59 FCGR1A
8 malaria 29.9 CD40LG CD55 GYPA HP RHD
9 acquired angioedema 29.8 C1S C3 HP
10 marginal zone b-cell lymphoma 29.8 C1S CD40LG CD5
11 drug-induced autoimmune hemolytic anemia 12.6
12 mixed-type autoimmune hemolytic anemia 12.4
13 autoimmune hemolytic anemia, warm type 12.4
14 lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmune hemolytic anemia, and glomerulonephritis 12.3
15 neonatal autoimmune hemolytic anemia 12.3
16 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 12.3
17 warm antibody hemolytic anemia 12.2
18 evans' syndrome 11.8
19 cold agglutinin disease 11.6
20 purine nucleoside phosphorylase deficiency 11.5
21 immunodeficiency, common variable, 8, with autoimmunity 11.3
22 paroxysmal cold hemoglobinuria 11.3
23 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.2
24 autoimmune lymphoproliferative syndrome 11.2
25 autoimmune lymphoproliferative syndrome, type iia 11.2
26 immunodeficiency 10 11.2
27 lymphoproliferative syndrome 1 11.2
28 ras-associated autoimmune leukoproliferative disorder 11.2
29 idiopathic cd4-positive t-lymphocytopenia 11.2
30 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 11.2
31 lymphocytic leukemia 10.8
32 leukemia, chronic lymphocytic 2 10.8
33 leukemia, chronic lymphocytic 10.8
34 leukemia, b-cell, chronic 10.8
35 lymphoma 10.7
36 pure red-cell aplasia 10.5
37 ulcerative colitis 10.5
38 colitis 10.5
39 purpura 10.5
40 hepatitis c 10.5
41 hematopoietic stem cell transplantation 10.4
42 viral infectious disease 10.4
43 primary biliary cholangitis 10.4
44 biliary cirrhosis, primary, 1 10.4
45 primary biliary cirrhosis 10.4
46 cholangitis 10.4
47 lymphoma, hodgkin, classic 10.4
48 sclerosing cholangitis 10.4
49 thrombocytopenic purpura, autoimmune 10.3
50 myeloma, multiple 10.3

Comorbidity relations with Anemia, Autoimmune Hemolytic via Phenotypic Disease Network (PDN):


Acquired Thrombocytopenia Acute Cystitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Leukemia, Chronic Lymphocytic
Neutropenia

Graphical network of the top 20 diseases related to Anemia, Autoimmune Hemolytic:



Diseases related to Anemia, Autoimmune Hemolytic
Sources

Symptoms & Phenotypes for Anemia, Autoimmune Hemolytic

About this section

Symptoms via clinical synopsis from OMIM:

57
Heme:
autoimmune hemolytic anemia

Lab:
coombs positive
abnormal immunoglobulin in heterozygotes


Clinical features from OMIM:

205700

Human phenotypes related to Anemia, Autoimmune Hemolytic:

32 (show all 18)
# Description HPO Frequency HPO Source Accession
1 muscle weakness 32 hallmark (90%) HP:0001324
2 splenomegaly 32 occasional (7.5%) HP:0001744
3 fever 32 occasional (7.5%) HP:0001945
4 fatigue 32 hallmark (90%) HP:0012378
5 abnormality of metabolism/homeostasis 32 HP:0001939
6 dyspnea 32 hallmark (90%) HP:0002094
7 arrhythmia 32 occasional (7.5%) HP:0011675
8 immunodeficiency 32 frequent (33%) HP:0002721
9 hemolytic anemia 32 hallmark (90%) HP:0001878
10 pallor 32 frequent (33%) HP:0000980
11 abdominal pain 32 occasional (7.5%) HP:0002027
12 congestive heart failure 32 occasional (7.5%) HP:0001635
13 autoimmunity 32 hallmark (90%) HP:0002960
14 lymphoma 32 frequent (33%) HP:0002665
15 headache 32 hallmark (90%) HP:0002315
16 abnormal urinary color 32 occasional (7.5%) HP:0012086
17 autoimmune hemolytic anemia 32 HP:0001890
18 abnormal leukocyte morphology 32 hallmark (90%) HP:0001881

GenomeRNAi Phenotypes related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 C3 CD5 CD59 CHAD FCGR1A

MGI Mouse Phenotypes related to Anemia, Autoimmune Hemolytic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.28 C3 CD40LG CD5 CD55 CD59 FCGR1A
Sources

Drugs & Therapeutics for Anemia, Autoimmune Hemolytic

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Drugs for Anemia, Autoimmune Hemolytic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-24-8 5755
2
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Not Applicable 2921-57-5
4
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 83-43-2 6741
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
6
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
7
Fludarabine Approved Phase 3,Phase 2 75607-67-9, 21679-14-1 30751
8
Vidarabine Approved, Investigational Phase 3,Phase 2 24356-66-9 32326 21704
9
Ofatumumab Approved Phase 3,Phase 2 679818-59-8 6918251
10
Chlorambucil Approved Phase 3,Phase 2 305-03-3 2708
11
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Not Applicable 2920-86-7
12 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
13 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
14 Hormones Phase 3,Phase 2,Not Applicable
15 Prednisolone acetate Phase 3,Phase 2,Not Applicable
16 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
17 Hormone Antagonists Phase 3,Phase 2,Not Applicable
18 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Autonomic Agents Phase 3,Phase 2,Not Applicable
20 Antiemetics Phase 3,Phase 2,Not Applicable
21 Protective Agents Phase 3,Phase 2,Not Applicable
22 Antibodies Phase 3,Phase 2
23 Immunoglobulins Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
25 Neuroprotective Agents Phase 3,Phase 2,Not Applicable
26 glucocorticoids Phase 3,Phase 2,Not Applicable
27 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
28 Methylprednisolone acetate Phase 3,Phase 2,Not Applicable
29 Gastrointestinal Agents Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
31 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
32 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
33 Alkylating Agents Phase 3,Phase 2,Not Applicable
34 Antiviral Agents Phase 3,Phase 2,Phase 1
35 Antimetabolites, Antineoplastic Phase 3,Phase 2
36 Antibodies, Monoclonal Phase 3,Phase 2
37 Antimetabolites Phase 3,Phase 2
38
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
39
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
40
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
41
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
42
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
43
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
44
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
45
alemtuzumab Approved, Investigational Phase 2 216503-57-0
46
Doxil Approved June 1999 Phase 2 31703
47
Lactitol Investigational Phase 1, Phase 2 585-86-4 3871
48 Antiparasitic Agents Phase 2
49 Autoantibodies Phase 2
50 Adjuvants, Immunologic Phase 2

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Rituximab in Auto-Immune Hemolytic Anemia Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
2 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
3 Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia Completed NCT00824265 Phase 3 OFC Infusion;FC infusion
4 Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia Completed NCT00748189 Phase 3 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
5 Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy Completed NCT01039376 Phase 3
6 Ofatumumab vs Physician's Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia Completed NCT01313689 Phase 3 Ofatumumab;Physicians' Choice
7 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA Not yet recruiting NCT03764618 Phase 3 Fostamatinib disodium;Placebo
8 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
9 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
10 Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
11 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2 Bendamustine, Rituximab
12 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2 Rituximab;Fludarabine
13 Bortezomib to Treat Significant Complication of HSCT Completed NCT01929980 Phase 2 Bortezomib
14 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2 cyclophosphamide;filgrastim
15 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
16 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
17 A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia Completed NCT01563055 Phase 2 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
18 A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia Recruiting NCT03538041 Phase 2 INCB050465
19 Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With wAIHA or CAD Recruiting NCT03226678 Phase 2 APL-2
20 Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Recruiting NCT02389231 Phase 1, Phase 2 Interleukine-2
21 A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) Active, not recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
22 The Efficacy and Safety of Alemtuzumab in Auotoimmune Cytopenias Terminated NCT00472433 Phase 2 Alemtuzumab
23 Treatment of Autoimmune Thrombocytopenia (AITP) Completed NCT00001630 Phase 1
24 A Safety Study of SYNT001 in Subjects With Chronic, Stable Warm Autoimmune Hemolytic Anemia (WAIHA) Recruiting NCT03075878 Phase 1 SYNT001
25 Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1 BIV009
26 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
27 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219
28 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
29 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
30 Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA) Recruiting NCT02828670
31 Immunopathology of Autoimmune Hemolytic Anemia Recruiting NCT02158195
32 Autoimmune Cytopenias : Midi-Pyrenees Registry Recruiting NCT02877706
33 Severe Immune Cytopenia Registry Www.Sic-reg.Org Recruiting NCT03576742
34 One Year Hospital Data Patients With AIHA in Assiut University Hospital - Clinical Hematology Unit Not yet recruiting NCT03269292
35 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805

Search NIH Clinical Center for Anemia, Autoimmune Hemolytic

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: anemia, hemolytic, autoimmune

Sources

Genetic Tests for Anemia, Autoimmune Hemolytic

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Genetic tests related to Anemia, Autoimmune Hemolytic:

# Genetic test Affiliating Genes
1 Autoimmune Hemolytic Anemia 29
Sources

Anatomical Context for Anemia, Autoimmune Hemolytic

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MalaCards organs/tissues related to Anemia, Autoimmune Hemolytic:

41
Testes, B Cells, T Cells, Liver, Bone, Bone Marrow, Thyroid
Sources

Publications for Anemia, Autoimmune Hemolytic

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Articles related to Anemia, Autoimmune Hemolytic:

(show top 50) (show all 1050)
# Title Authors Year
1
Exacerbation of autoimmune hemolytic anemia induced by the first dose of programmed death-1 inhibitor pembrolizumab: a case report. ( 29340837 )
2018
2
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
3
Mixed IgM cold and IgG warm autoimmune hemolytic anemia complicated by acral gangrene. ( 29683507 )
2018
4
Ominous comorbidities: Small ventricular septal defect and warm autoimmune hemolytic anemia. ( 29440848 )
2018
5
Splenic myeloid metaplasia in warm autoimmune hemolytic anemia (wAIHA): a retrospective study. ( 29662860 )
2018
6
Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis. ( 29359617 )
2018
7
Eluate testing with monospecific antisera unmasks multiple immunoglobulin classes and identifies frequent IgA involvement in severe autoimmune hemolytic anemia. ( 29716828 )
2018
8
Features of peripheral CD8<sup>+</sup>CD57<sup>+</sup> lymphocytes in patients with autoimmune hemolytic anemia. ( 29845877 )
2018
9
Efficacy of D- red blood cell transfusion and rituximab therapy in autoimmune hemolytic anemia with anti-D and panreactive autoantibodies arising after hematopoietic stem cell transplant. ( 29664112 )
2018
10
Durable responses in refractory autoimmune hemolytic anemia with alemtuzumab. ( 29334337 )
2018
11
Predictors of refractoriness to therapy and healthcare resource utilization in 378 patients with primary autoimmune hemolytic anemia from 8 Italian Reference Centers. ( 29981267 )
2018
12
Should Giant Cell Hepatitis With Autoimmune Hemolytic Anemia Be Considered a Pediatric Autoimmune Liver Disease? ( 29394216 )
2018
13
Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. ( 30527923 )
2018
14
Acute Brucellosis Presenting as an Autoimmune Hemolytic Anemia. ( 30498608 )
2018
15
Severe warm-antibody autoimmune hemolytic anemia due to multicentric Castleman disease: Responding to rituximab. ( 30486744 )
2018
16
A Unique Triad: Ulcerative Colitis, Primary Sclerosing Cholangitis, and Autoimmune Hemolytic Anemia. ( 29552430 )
2018
17
Complications of a severe autoimmune hemolytic anemia crisis: transfusional iron overload and gangrenous cholecystitis. ( 30291762 )
2018
18
Complement Activation and Inhibition in Autoimmune Hemolytic Anemia: Focus on Cold Agglutinin Disease. ( 30032751 )
2018
19
Safety and Efficacy of Laparoscopic Oophorocystectomy for Ovarian Dermoid Cyst Associated With Autoimmune Hemolytic Anemia. ( 30254931 )
2018
20
Bartonella endocarditis in a child with tetralogy of Fallot complicated by PR3-ANCA positive serology, autoimmune hemolytic anemia, and acute kidney injury. ( 29988634 )
2018
21
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. ( 29557617 )
2018
22
Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation. ( 30291113 )
2018
23
Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Español de Trasplante Hematopoyetico (GETH). ( 29573905 )
2018
24
Artesunate-Induced Severe Autoimmune Hemolytic Anemia in Complicated Malaria. ( 30405291 )
2018
25
Venous thromboembolic events during warm autoimmune hemolytic anemia. ( 30408135 )
2018
26
Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report. ( 30466224 )
2018
27
Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab. ( 30480056 )
2018
28
Autoimmune hemolytic anemia. ( 30504336 )
2018
29
Prognosis of autoimmune hemolytic anemia in critically ill patients. ( 30536106 )
2018
30
Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature. ( 30537439 )
2018
31
Acute autoimmune hemolytic anemia due to anti-Ena autoantibody successfully treated with rituximab. ( 29023757 )
2018
32
Clinical severity in adult warm autoimmune hemolytic anemia and its relationship to antibody specificity. ( 29025905 )
2018
33
Severe Warm Autoimmune Hemolytic Anemia in a 7-Month-Old Infant Associated With a Mycoplasma Pneumoniae Infection. ( 29135841 )
2018
34
miR-150 regulates B lymphocyte in autoimmune hemolytic anemia/Evans syndrome by c-Myb. ( 29488168 )
2018
35
Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature. ( 29515411 )
2018
36
A Case of Warm Autoimmune Hemolytic Anemia With a Direct Antiglobulin Test Positive for C3 in Rheumatoid Arthritis Patient Successfully Treated With Low-Dose Rituximab. ( 29561472 )
2018
37
Autoimmune hemolytic anemia associated with infliximab infusion in ulcerative colitis. ( 29607436 )
2018
38
Tacrolimus-Induced Autoimmune Hemolytic Anemia in a Previously Reported Child With History of Thrombocytopenia Following Liver Transplant. ( 29633932 )
2018
39
A Comprehensive Diagnostic Algorithm for Direct Antiglobulin Test-Negative Autoimmune Hemolytic Anemia Reveals the Relative Ratio of Three Mechanisms in a Single Laboratory. ( 30007985 )
2018
40
Direct Antiglobulin Test-Negative Autoimmune Hemolytic Anemia. ( 30007988 )
2018
41
A case of chronic lymphocytic leukemia complicated by autoimmune hemolytic anemia due to ibrutinib treatment. ( 30012921 )
2018
42
Ectopic expression of band 3 anion transport protein in colorectal cancer revealed in an autoimmune hemolytic anemia patient. ( 30063906 )
2018
43
Immunoglobulin G4-related Kidney Disease Associated With Autoimmune Hemolytic Anemia. ( 30087220 )
2018
44
Current treatment options for severe autoimmune hemolytic anemia. ( 30116136 )
2018
45
Re: Current treatment options for severe autoimmune hemolytic anemia. ( 30116137 )
2018
46
Autoimmune hemolytic anemia: An unusual presentation of hemophagocytic lymphohistiocytosis in a pediatric post-liver transplant patient. ( 30129086 )
2018
47
Clinical features and treatment of primary autoimmune hemolytic anemia in childhood. ( 30146455 )
2018
48
Murine models of autoimmune hemolytic anemia. ( 30169458 )
2018
49
Successful treatment of severe refractory autoimmune hemolytic anemia after hematopoietic stem cell transplant with abatacept. ( 30179262 )
2018
50
Recurrent autoimmune hemolytic anemia in splenic marginal zone lymphoma. ( 30181837 )
2018
Sources

Variations for Anemia, Autoimmune Hemolytic

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Sources

Expression for Anemia, Autoimmune Hemolytic

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Search GEO for disease gene expression data for Anemia, Autoimmune Hemolytic.
Sources

Pathways for Anemia, Autoimmune Hemolytic

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Pathways related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.67 C1S C3 CD40LG CD55 CD59 FCGR1A
2
Toxoplasmosis 37
Show member pathways
 11.9 C3 CD40LG FCGR1A
3
Creation of C4 and C2 activators 66
Show member pathways
 11.78 C1S C3 CD55 CD59
4
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.74 C3 CD40LG FCGR1A
5
Complement and coagulation cascades 1 37
11.7 C1S C3 CD55 CD59
6
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.64 CD5 CD59 GYPA
7
Immune response Lectin induced complement pathway 22
Show member pathways
 11.58 C1S C3 CD55 CD59
8
Staphylococcus aureus infection 37
11.29 C1S C3 FCGR1A
9
Complement Pathway 64
Show member pathways
 11.28 C1S C3 CD55 CD59
10
Malaria 37
11.2 CD40LG GYPA
11
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
11.15 FCGR1A SIRPA
12
Hematopoietic cell lineage 37
11.01 CD5 CD55 CD59 FCGR1A GYPA
Sources

GO Terms for Anemia, Autoimmune Hemolytic

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Cellular components related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 CD40LG CD55 CD59 SIRPA
2 extracellular space GO:0005615 9.43 C1S C3 CD40LG CD59 CHAD HP
3 blood microparticle GO:0072562 8.8 C1S C3 HP

Biological processes related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.67 C1S C3 CD55 FCGR1A
2 regulation of immune response GO:0050776 9.61 C3 CD40LG FCGR1A
3 receptor-mediated endocytosis GO:0006898 9.58 CD5 FCGR1A HP
4 complement activation, classical pathway GO:0006958 9.5 C1S C3 CD55
5 positive regulation of phagocytosis GO:0050766 9.46 C3 SIRPA
6 neutrophil degranulation GO:0043312 9.35 C3 CD55 CD59 HP SIRPA
7 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
8 ammonium transport GO:0015696 9.16 RHCE RHD
9 regulation of complement activation GO:0030449 8.92 C1S C3 CD55 CD59

Molecular functions related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 C1S C3 HP
2 ammonium transmembrane transporter activity GO:0008519 8.62 RHCE RHD
Sources

Sources for Anemia, Autoimmune Hemolytic

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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