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MCID: ANM038
MIFTS: 59

Anemia, Autoimmune Hemolytic

Categories: Blood diseases, Genetic diseases, Immune diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anemia, Autoimmune Hemolytic

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MalaCards integrated aliases for Anemia, Autoimmune Hemolytic:

Name: Anemia, Autoimmune Hemolytic 58
Autoimmune Hemolytic Anemia 12 77 54 38 30 56 15 74
Idiopathic Autoimmune Hemolytic Anemia 54 74
Anemia, Hemolytic, Autoimmune 45 17
Immuno-Hemolytic Anemia 54 74
Familial Auto-Immune Hemolytic Anemia 54
Acquired Autoimmune Hemolytic Anemia 54
Autoimmune Haemolytic Anaemia 12
Anemia Hemolytic Autoimmune 54

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
anemia, autoimmune hemolytic:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases Genetic diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Anemia, Autoimmune Hemolytic

About this section
NIH Rare Diseases : 54 Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions.

MalaCards based summary : Anemia, Autoimmune Hemolytic, also known as autoimmune hemolytic anemia, is related to evans' syndrome and hemolytic anemia. An important gene associated with Anemia, Autoimmune Hemolytic is HP (Haptoglobin), and among its related pathways/superpathways are Toxoplasmosis and Creation of C4 and C2 activators. The drugs Tacrolimus and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and testes, and related phenotypes are muscle weakness and fatigue

Disease Ontology : 12 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia : 77 Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person''s own red blood... more...

Description from OMIM: 205700
Sources

Related Diseases for Anemia, Autoimmune Hemolytic

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Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Anemia, Autoimmune Hemolytic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 365)
# Related Disease Score Top Affiliating Genes
1 evans' syndrome 32.9 HP LRBA
2 hemolytic anemia 31.2 C3 CD55 CD59 HP
3 paroxysmal nocturnal hemoglobinuria 30.5 CD55 CD59 HP
4 immunoglobulin alpha deficiency 30.2 CD40LG HP
5 acquired angioedema 30.2 C3 HP
6 hemoglobinuria 30.2 C3 CD55 CD59 HP
7 cryoglobulinemia 30.2 CD40LG CD5
8 complement deficiency 30.1 C3 CD59
9 marginal zone b-cell lymphoma 29.9 CD40LG CD5
10 malaria 29.8 CD40LG CD55 GYPA HP RHD
11 drug-induced autoimmune hemolytic anemia 12.7
12 mixed-type autoimmune hemolytic anemia 12.5
13 autoimmune hemolytic anemia, warm type 12.5
14 lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmune hemolytic anemia, and glomerulonephritis 12.3
15 neonatal autoimmune hemolytic anemia 12.3
16 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 12.3
17 warm antibody hemolytic anemia 12.3
18 cold agglutinin disease 11.7
19 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.5
20 purine nucleoside phosphorylase deficiency 11.5
21 immunodeficiency, common variable, 8, with autoimmunity 11.4
22 paroxysmal cold hemoglobinuria 11.4
23 autoimmune lymphoproliferative syndrome 11.2
24 autoimmune lymphoproliferative syndrome, type iia 11.2
25 immunodeficiency 10 11.2
26 lymphoproliferative syndrome 1 11.2
27 ras-associated autoimmune leukoproliferative disorder 11.2
28 idiopathic cd4-positive t-lymphocytopenia 11.2
29 autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency 11.2
30 combined immunodeficiency due to partial rag1 deficiency 11.2
31 lupus erythematosus 10.6
32 systemic lupus erythematosus 10.6
33 purpura 10.5
34 hepatitis c 10.5
35 hematopoietic stem cell transplantation 10.4
36 primary biliary cholangitis 10.4
37 biliary cirrhosis, primary, 1 10.4
38 primary biliary cirrhosis 10.4
39 cholangitis 10.4
40 thrombocytopenic purpura, autoimmune 10.4
41 lymphoma, hodgkin, classic 10.4
42 sclerosing cholangitis 10.4
43 deficiency anemia 10.4
44 glomerulonephritis 10.3
45 cryofibrinogenemia 10.3 CD40LG HP
46 multiple congenital anomalies-hypotonia-seizures syndrome 2 10.3 CD55 CD59
47 myasthenia gravis 10.3
48 myeloma, multiple 10.3
49 sjogren syndrome 10.3
50 autoimmune hepatitis 10.3

Comorbidity relations with Anemia, Autoimmune Hemolytic via Phenotypic Disease Network (PDN):


Acquired Thrombocytopenia Acute Cystitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Leukemia, Chronic Lymphocytic
Neutropenia

Graphical network of the top 20 diseases related to Anemia, Autoimmune Hemolytic:



Diseases related to Anemia, Autoimmune Hemolytic
Sources

Symptoms & Phenotypes for Anemia, Autoimmune Hemolytic

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Human phenotypes related to Anemia, Autoimmune Hemolytic:

33 (show all 18)
# Description HPO Frequency HPO Source Accession
1 muscle weakness 33 hallmark (90%) HP:0001324
2 fatigue 33 hallmark (90%) HP:0012378
3 dyspnea 33 hallmark (90%) HP:0002094
4 hemolytic anemia 33 hallmark (90%) HP:0001878
5 autoimmunity 33 hallmark (90%) HP:0002960
6 headache 33 hallmark (90%) HP:0002315
7 abnormal leukocyte morphology 33 hallmark (90%) HP:0001881
8 immunodeficiency 33 frequent (33%) HP:0002721
9 pallor 33 frequent (33%) HP:0000980
10 lymphoma 33 frequent (33%) HP:0002665
11 splenomegaly 33 occasional (7.5%) HP:0001744
12 fever 33 occasional (7.5%) HP:0001945
13 arrhythmia 33 occasional (7.5%) HP:0011675
14 abdominal pain 33 occasional (7.5%) HP:0002027
15 congestive heart failure 33 occasional (7.5%) HP:0001635
16 abnormal urinary color 33 occasional (7.5%) HP:0012086
17 abnormality of metabolism/homeostasis 33 HP:0001939
18 autoimmune hemolytic anemia 33 HP:0001890

Symptoms via clinical synopsis from OMIM:

58
Heme:
autoimmune hemolytic anemia

Lab:
coombs positive
abnormal immunoglobulin in heterozygotes

Clinical features from OMIM:

205700

GenomeRNAi Phenotypes related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 C3 CD5 CD59 CHAD FCGR1A

MGI Mouse Phenotypes related to Anemia, Autoimmune Hemolytic:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 C3 CD40LG CD5 CD55 CD59 FCGR1A
2 immune system MP:0005387 9.17 C3 CD40LG CD5 FCGR1A HP LRBA
Sources

Drugs & Therapeutics for Anemia, Autoimmune Hemolytic

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Drugs for Anemia, Autoimmune Hemolytic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 6473866 445643 439492
2 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
3 Calcineurin Inhibitors Phase 4,Not Applicable
4 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 302-25-0
6
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-24-8 5755
7
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Not Applicable 2921-57-5
8
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 83-43-2 6741
9
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
10
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
11
Fludarabine Approved Phase 3,Phase 2 75607-67-9, 21679-14-1 30751
12
ofatumumab Approved Phase 3,Phase 2 679818-59-8 6918251
13
Vidarabine Approved, Investigational Phase 3,Phase 2 24356-66-9 21704 32326
14
Chlorambucil Approved Phase 3,Phase 2 305-03-3 2708
15
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Not Applicable 2920-86-7
16 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
17 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
18 Prednisolone acetate Phase 3,Phase 2,Not Applicable
19 Protective Agents Phase 3,Phase 2,Not Applicable
20 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Not Applicable
21 Neuroprotective Agents Phase 3,Phase 2,Not Applicable
22 Hormone Antagonists Phase 3,Phase 2,Not Applicable
23 Hormones Phase 3,Phase 2,Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
25 Antibodies Phase 3,Phase 2
26 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
27 Gastrointestinal Agents Phase 3,Phase 2,Not Applicable
28 Methylprednisolone Acetate Phase 3,Phase 2,Not Applicable
29 Antiemetics Phase 3,Phase 2,Not Applicable
30 glucocorticoids Phase 3,Phase 2,Not Applicable
31 Immunoglobulins Phase 3,Phase 2
32 Autonomic Agents Phase 3,Phase 2,Not Applicable
33 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Not Applicable
34 Alkylating Agents Phase 3,Phase 2,Not Applicable
35 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
36 Autoantibodies Phase 3,Phase 2
37 Antineoplastic Agents, Immunological Phase 3,Phase 2
38 Antimetabolites, Antineoplastic Phase 3,Phase 2
39 Antimetabolites Phase 3,Phase 2
40 Antiviral Agents Phase 3,Phase 1,Phase 2
41 Antibodies, Monoclonal Phase 3,Phase 2
42
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
43
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
44
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
45
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
46
Aldesleukin Approved Phase 1, Phase 2 110942-02-4, 85898-30-2
47
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
48
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
49
alemtuzumab Approved, Investigational Phase 2 216503-57-0
50
Doxil Approved June 1999 Phase 2 31703

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Tacrolimus Treatment for Refractory Autoimmune Cytopenia Not yet recruiting NCT03918265 Phase 4 Tacrolimus
2 Rituximab in Auto-Immune Hemolytic Anemia Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
3 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
4 Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia Completed NCT00824265 Phase 3 OFC Infusion;FC infusion
5 Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia Completed NCT00748189 Phase 3 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
6 Ofatumumab vs Physician's Choice in Subjects With Bulky Fludarabine-Refractory Chronic Lymphocytic Leukemia Completed NCT01313689 Phase 3 Ofatumumab;Physicians' Choice
7 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of wAIHA Recruiting NCT03764618 Phase 3 Fostamatinib disodium;Placebo
8 Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy Terminated NCT01039376 Phase 3
9 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
10 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
11 Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
12 Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Completed NCT02389231 Phase 1, Phase 2 Interleukine-2
13 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2 Bendamustine, Rituximab
14 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2 Rituximab;Fludarabine
15 Bortezomib to Treat Significant Complication of HSCT Completed NCT01929980 Phase 2 Bortezomib
16 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2 cyclophosphamide;filgrastim
17 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
18 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
19 A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia Completed NCT01563055 Phase 2 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
20 A Study of Parsaclisib in Participants With Autoimmune Hemolytic Anemia Recruiting NCT03538041 Phase 2 Parsaclisib
21 Ibrutinib in Steroid Refractory Autoimmune Hemolytic Anemia Recruiting NCT03827603 Phase 2 Ibrutinib
22 A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) Active, not recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
23 Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With wAIHA or CAD Active, not recruiting NCT03226678 Phase 2 APL-2
24 The Efficacy and Safety of Alemtuzumab in Auotoimmune Cytopenias Terminated NCT00472433 Phase 2 Alemtuzumab
25 Treatment of Autoimmune Thrombocytopenia (AITP) Completed NCT00001630 Phase 1
26 A Safety Study of SYNT001 in Subjects With Chronic, Stable Warm Autoimmune Hemolytic Anemia (WAIHA) Recruiting NCT03075878 Phase 1 SYNT001
27 Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1 BIV009
28 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
29 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219
30 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713 Rituximab (MABTHERA® or RITUXAN®).
31 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
32 Role of T Follicular Helper Cells in Autoimmune Hemolytic Anemia (TFH in AIHA) Recruiting NCT02828670
33 Immunopathology of Autoimmune Hemolytic Anemia Recruiting NCT02158195
34 Autoimmune Cytopenias : Midi-Pyrenees Registry Recruiting NCT02877706
35 Severe Immune Cytopenia Registry Www.Sic-reg.Org Recruiting NCT03576742
36 One Year Hospital Data Patients With AIHA in Assiut University Hospital - Clinical Hematology Unit Not yet recruiting NCT03269292
37 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805

Search NIH Clinical Center for Anemia, Autoimmune Hemolytic

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: anemia, hemolytic, autoimmune

Sources

Genetic Tests for Anemia, Autoimmune Hemolytic

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Genetic tests related to Anemia, Autoimmune Hemolytic:

# Genetic test Affiliating Genes
1 Autoimmune Hemolytic Anemia 30
Sources

Anatomical Context for Anemia, Autoimmune Hemolytic

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MalaCards organs/tissues related to Anemia, Autoimmune Hemolytic:

42
T Cells, B Cells, Testes, Liver, Bone, Lung, Bone Marrow
Sources

Publications for Anemia, Autoimmune Hemolytic

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Articles related to Anemia, Autoimmune Hemolytic:

(show top 50) (show all 1222)
# Title Authors Year
1
Hot and Cold: A Concurrent Warm and Cold Autoimmune Hemolytic Anemia in B-cell Prolymphocytic Leukemia. ( 30947164 )
2019
2
Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review. ( 30347480 )
2019
3
Prognosis of autoimmune hemolytic anemia in critically ill patients. ( 30536106 )
2019
4
Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature. ( 30537439 )
2019
5
IgM-mediated Warm Autoimmune Hemolytic Anemia: An Autopsy Report. ( 30568122 )
2019
6
Cold type autoimmune hemolytic anemia- a rare manifestation of infectious mononucleosis; serum ferritin as an important biomarker. ( 30658594 )
2019
7
Low-dose rituximab in autoimmune hemolytic anemia: 10 years after. ( 30670440 )
2019
8
Immunosensor for the Diagnostics of Autoimmune Hemolytic Anemia (AIHA) Based on Immobilization of a Monoclonal Antibody on a Layer of Silk Fibroin. ( 30764933 )
2019
9
Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. ( 30790338 )
2019
10
Pembrolizumab-induced Autoimmune Hemolytic Anemia and Hemophagocytic Lymphohistiocytosis in Non-small Cell Lung Cancer. ( 30828042 )
2019
11
Autoimmune Hemolytic Anemia, Erythrophagocytosis and Liver Dysfunction After Cefixime Use for Urinary Tract Infection in a Child. ( 30828180 )
2019
12
Autoimmune hemolytic anemia and ovarian dermoid cysts in pregnancy. ( 30957135 )
2019
13
B-cell depletion induces prolonged remission in patients with giant cell hepatitis and autoimmune hemolytic anemia. ( 31076361 )
2019
14
A case series of pediatric patients with direct antiglobulin test negative autoimmune hemolytic anemia. ( 31111963 )
2019
15
Durable responses in refractory autoimmune hemolytic anemia with alemtuzumab. ( 29334337 )
2019
16
Ectopic expression of band 3 anion transport protein in colorectal cancer revealed in an autoimmune hemolytic anemia patient. ( 30063906 )
2019
17
Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly. ( 30527923 )
2018
18
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )
2018
19
Acute Brucellosis Presenting as an Autoimmune Hemolytic Anemia. ( 30498608 )
2018
20
Severe warm-antibody autoimmune hemolytic anemia due to multicentric Castleman disease: Responding to rituximab. ( 30486744 )
2018
21
A Unique Triad: Ulcerative Colitis, Primary Sclerosing Cholangitis, and Autoimmune Hemolytic Anemia. ( 29552430 )
2018
22
Complications of a severe autoimmune hemolytic anemia crisis: transfusional iron overload and gangrenous cholecystitis. ( 30291762 )
2018
23
Complement Activation and Inhibition in Autoimmune Hemolytic Anemia: Focus on Cold Agglutinin Disease. ( 30032751 )
2018
24
Safety and Efficacy of Laparoscopic Oophorocystectomy for Ovarian Dermoid Cyst Associated With Autoimmune Hemolytic Anemia. ( 30254931 )
2018
25
Bartonella endocarditis in a child with tetralogy of Fallot complicated by PR3-ANCA positive serology, autoimmune hemolytic anemia, and acute kidney injury. ( 29988634 )
2018
26
Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report. ( 29557617 )
2018
27
Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation. ( 30291113 )
2018
28
Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo Español de Trasplante Hematopoyetico (GETH). ( 29573905 )
2018
29
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
30
Case report of mixed-type autoimmune hemolytic anemia in a patient with relapsing polychondritis. ( 30290676 )
2018
31
Heterozygous Mutation in Adenosine Deaminase Gene in a Patient With Severe Lymphopenia Following Corticosteroid Treatment of Autoimmune Hemolytic Anemia. ( 30327760 )
2018
32
Artesunate-Induced Severe Autoimmune Hemolytic Anemia in Complicated Malaria. ( 30405291 )
2018
33
Venous thromboembolic events during warm autoimmune hemolytic anemia. ( 30408135 )
2018
34
Quetiapine Induced Autoimmune Hemolytic Anemia in a Child Patient: A Case Report. ( 30466224 )
2018
35
Refractory Chronic Pouchitis and Autoimmune Hemolytic Anemia Successfully Treated with Vedolizumab. ( 30480056 )
2018
36
Autoimmune hemolytic anemia. ( 30504336 )
2018
37
Gastric duplication cyst in an adult with autoimmune hemolytic anemia: a case report and review of the literature. ( 30585141 )
2018
38
Immunohematological and clinical characterizations of mixed autoimmune hemolytic anemia. ( 30692792 )
2018
39
Acute autoimmune hemolytic anemia due to anti-Ena autoantibody successfully treated with rituximab. ( 29023757 )
2018
40
Clinical severity in adult warm autoimmune hemolytic anemia and its relationship to antibody specificity. ( 29025905 )
2018
41
Severe Warm Autoimmune Hemolytic Anemia in a 7-Month-Old Infant Associated With a Mycoplasma Pneumoniae Infection. ( 29135841 )
2018
42
Prognostic impact of bone marrow fibrosis and dyserythropoiesis in autoimmune hemolytic anemia. ( 29274091 )
2018
43
C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice. ( 29277896 )
2018
44
Exacerbation of autoimmune hemolytic anemia induced by the first dose of programmed death-1 inhibitor pembrolizumab: a case report. ( 29340837 )
2018
45
Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis. ( 29359617 )
2018
46
Should Giant Cell Hepatitis With Autoimmune Hemolytic Anemia Be Considered a Pediatric Autoimmune Liver Disease? ( 29394216 )
2018
47
Ominous comorbidities: Small ventricular septal defect and warm autoimmune hemolytic anemia. ( 29440848 )
2018
48
miR-150 regulates B lymphocyte in autoimmune hemolytic anemia/Evans syndrome by c-Myb. ( 29488168 )
2018
49
Rosai-Dorfman Disease Complicated by Autoimmune Hemolytic Anemia in a Child: A Case Report and Review of the Literature. ( 29515411 )
2018
50
A Case of Warm Autoimmune Hemolytic Anemia With a Direct Antiglobulin Test Positive for C3 in Rheumatoid Arthritis Patient Successfully Treated With Low-Dose Rituximab. ( 29561472 )
2018
Sources

Variations for Anemia, Autoimmune Hemolytic

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Sources

Expression for Anemia, Autoimmune Hemolytic

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Search GEO for disease gene expression data for Anemia, Autoimmune Hemolytic.
Sources

Pathways for Anemia, Autoimmune Hemolytic

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Pathways related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Toxoplasmosis 38
Show member pathways
 11.88 C3 CD40LG FCGR1A
2
Creation of C4 and C2 activators 67
Show member pathways
 11.74 C3 CD55 CD59
3
Complement and coagulation cascades 1 38
11.69 C3 CD55 CD59
4
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 67
11.63 C3 CD40LG FCGR1A
5
Immune response Lectin induced complement pathway 23
Show member pathways
 11.56 C3 CD55 CD59
6
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.4 CD5 CD59 GYPA
7
Malaria 38
11.17 CD40LG GYPA
8
Complement Pathway 65
Show member pathways
 11.16 C3 CD55 CD59
9
Microglia Activation During Neuroinflammation: Steady-State Microglia 66
11.11 FCGR1A SIRPA
10
Hematopoietic cell lineage 38
11.01 CD5 CD55 CD59 FCGR1A GYPA
Sources

GO Terms for Anemia, Autoimmune Hemolytic

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Cellular components related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.28 C3 CD40LG CD5 CD55 CD59 FCGR1A
2 cell surface GO:0009986 9.26 CD40LG CD55 CD59 SIRPA

Biological processes related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.54 C3 CD40LG FCGR1A
2 receptor-mediated endocytosis GO:0006898 9.5 CD5 FCGR1A HP
3 regulation of complement activation GO:0030449 9.43 C3 CD55 CD59
4 positive regulation of phagocytosis GO:0050766 9.4 C3 SIRPA
5 ammonium transmembrane transport GO:0072488 9.16 RHCE RHD
6 neutrophil degranulation GO:0043312 9.02 C3 CD55 CD59 HP SIRPA
7 ammonium transport GO:0015696 8.96 RHCE RHD

Molecular functions related to Anemia, Autoimmune Hemolytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ammonium transmembrane transporter activity GO:0008519 8.62 RHCE RHD
Sources

Sources for Anemia, Autoimmune Hemolytic

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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