MCID: ANM001
MIFTS: 31

Anemia of Prematurity

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD9CM 34 776.6
NCIt 50 C97167
SNOMED-CT 67 47100003
ICD10 32 P61.2
UMLS 70 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and iron metabolism disease. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are JAK-STAT signaling pathway and Hematopoietic Stem Cell Differentiation. The drugs Iron and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include myeloid, neutrophil and lung, and related phenotype is respiratory system.

Wikipedia : 73 Anemia of prematurity (AOP) refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 30.7 HAMP EPOR EPO CSF2
2 iron metabolism disease 30.3 HAMP EPO
3 hemosiderosis 30.0 HAMP EPO
4 iron deficiency anemia 29.9 HAMP EPO
5 enterocolitis 10.2
6 perinatal necrotizing enterocolitis 10.2
7 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.2 EPO CSF2
8 acute monoblastic leukemia 10.2 EPO CSF2
9 lumbosacral lipoma 10.2 EPOR EPO
10 progressive myoclonus epilepsy 9 10.2 EPOR EPO
11 acute erythroid leukemia 10.2 EPOR EPO
12 neonatal anemia 10.2 EPOR EPO
13 primary polycythemia 10.2 EPOR EPO
14 folic acid deficiency anemia 10.2 HAMP EPO
15 hypersplenism 10.2 EPO CSF2
16 erythrocytosis, familial, 1 10.1 EPOR EPO
17 lung clear cell carcinoma 10.1 HAMP EPO
18 hemochromatosis, type 3 10.1 HAMP EPOR
19 anemia, congenital dyserythropoietic, type ia 10.1 HAMP EPO
20 microcytic anemia 10.1 HAMP EPO
21 congenital dyserythropoietic anemia 10.1 HAMP EPO
22 chronic mountain sickness 10.0 EPO ANP32D
23 essential thrombocythemia 10.0 EPOR EPO CSF2
24 hemangioblastoma 10.0 EPOR EPO
25 myeloproliferative neoplasm 10.0 EPOR EPO CSF2
26 hemoglobin h disease 10.0 HAMP EPO
27 acquired polycythemia 10.0 HAMP EPOR EPO
28 polycythemia 10.0 HAMP EPOR EPO
29 erythrocytosis, familial, 2 10.0 HAMP EPOR EPO
30 exudative vitreoretinopathy 1 9.9
31 sudden infant death syndrome 9.9
32 yemenite deaf-blind hypopigmentation syndrome 9.9
33 patent ductus arteriosus 1 9.9
34 hemorrhagic disease 9.9
35 thrombocytosis 9.9
36 ischemia 9.9
37 bronchopulmonary dysplasia 9.9
38 rare hereditary hemochromatosis 9.9
39 diamond-blackfan anemia 9.9 EPOR EPO CSF2
40 beta-thalassemia 9.9 HAMP EPOR EPO
41 leukemia, chronic myeloid 9.9 EPOR EPO CSF2
42 nutritional deficiency disease 9.9 HAMP EPO
43 congenital hemolytic anemia 9.8 HAMP EPO
44 polycythemia vera 9.8 HAMP EPOR EPO CSF2
45 myelodysplastic syndrome 9.7 HAMP EPOR EPO CSF2
46 malaria 9.6 HAMP EPOR EPO CSF2

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 CSF2 EPO EPOR PDS5B PTGDR SCNN1A

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925 29936
2 Trace Elements Phase 4
3 Nutrients Phase 4
4 Micronutrients Phase 4
5 Iron Supplement Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants (ETTNO)- a Blinded Randomized Controlled Multicenter Trial Completed NCT01393496 Phase 4
2 Iron Supplementation and Intestinal Microbiome in Preterm Infants Not yet recruiting NCT04497012 Phase 4 2mg/kg/day Iron Sulfate;6 mg/kg/day Iron Sulfate
3 A Randomized Controlled Trial of Two Hemoglobin Thresholds for Transfusion in Newborns <1000g Birth Weight Completed NCT00182390 Phase 3
4 The Effect of Packed Red Blood Cell Transfusion on Superior Mesenteric Artery Blood Flow Velocity in Premature Infants After Feeding Completed NCT00167388 Phase 1
5 A Pilot Randomized Trial of Restrictive Red Blood Cell Transfusion Guidelines Used in Combination With Near-infrared Spectroscopy Splanchnic-cerebral Oxygenation Ratio Evaluations Versus Liberal Red Blood Cell Transfusion Guidelines in Preterm Infants Completed NCT02535208
6 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
7 Evaluation of the Efficacy and Safety of Autologous Cord Blood Transfusions in Premature Infants Completed NCT02101086
8 Comparison of Results of Near-Infrared Spectroscopy and Cranial Doppler Measurements in Premature Newborns With Anemia Recruiting NCT04509375
9 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates. Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

40
Myeloid, Neutrophil, Lung, Brain, Heart

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 222)
# Title Authors PMID Year
1
Anemia of prematurity: how low is too low? 61
33664467 2021
2
Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial. 61
32623628 2021
3
The role of recombinant Human erythropoietin in neonatal anemia. 61
31628923 2020
4
Survey on clinical use and non-use of recombinant human erythropoietin in European neonatal units. 61
32681780 2020
5
Hemodynamics of Different Volume of Red Blood Cell Transfusion in Preterm Infant. 61
32645234 2020
6
The development of intestinal dysbiosis in anemic preterm infants. 61
31992818 2020
7
Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth? 61
32315090 2020
8
Anemia of Prematurity and Oral Feeding Milestones in Premature Infants. 61
31777047 2019
9
Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction. 61
31669878 2019
10
Liberal hemoglobin threshold affects cerebral arterial pulsed Doppler and cardiac output, not cerebral tissue oxygenation: a prospective cohort study in anemic preterm infants. 61
31313334 2019
11
Updates in Red Blood Cell and Platelet Transfusions in Preterm Neonates. 61
31238357 2019
12
The Burden of Hypoxic Respiratory Failure in Preterm and Term/Near-term Infants in the United States 2011-2015. 61
32685586 2019
13
[Clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia: multicenter retrospective analysis]. 61
30630229 2019
14
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. 61
28783992 2018
15
Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates. 61
30178874 2018
16
Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? 61
29740185 2018
17
Comparison of Placental and Neonatal Admission Complete Blood Cell Count and Blood Cultures. 61
29578894 2018
18
Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis. 61
29767696 2018
19
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. 61
29535446 2018
20
Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants. 61
27346390 2017
21
[Focus on placental transfusion for preterm neonates: Delayed cord clamping and/or milking?] 61
27638229 2016
22
[Decreased transfusions in preterm infants with anemia treated with erythropoietin]. 61
27428338 2016
23
Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units. 61
26341125 2015
24
Diffuse neonatal hemangiomatosis in a very low-birthweight infant treated with erythropoietin. 61
25868957 2015
25
Immediate compared with delayed cord clamping in the preterm neonate: a randomized controlled trial. 61
25415157 2014
26
Measurement of posttransfusion red cell survival with the biotin label. 61
24969019 2014
27
Red blood cell transfusion in newborn infants. 61
24855419 2014
28
Evaluation of a new restricted transfusion protocol in neonates admitted to the NICU. 61
25678998 2014
29
Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants. 61
24135784 2014
30
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. 61
23521158 2013
31
[Clinical study of iron protein succinylate oral solution for preventing and treating anemia of prematurity]. 61
24342196 2013
32
Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. 61
24088873 2013
33
Preterm infant with a late presentation of blueberry muffin lesions secondary to recombinant erythropoietin. 61
24050292 2013
34
The effect of blood transfusion on cerebral hemodynamics in preterm infants. 61
23145971 2013
35
Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin. 61
23485870 2013
36
Risk factors of transfusion in anemia of very low birth weight infants. 61
23364969 2013
37
[Blood transfusions suppress erythropoiesis in anemia of prematurity]. 61
24501868 2013
38
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. 61
23540189 2012
39
Sucking improvement following blood transfusion for anemia of prematurity. 61
22664924 2012
40
Erythropoietin in anemia of prematurity. 61
23025776 2012
41
Late-onset blueberry muffin lesions following recombinant erythropoietin administration in a premature infant. 61
23007340 2012
42
Necrotizing enterocolitis and the role of anemia of prematurity. 61
22818548 2012
43
[Discussion on the clinical indications for blood transfusion in anemia of prematurity]. 61
22967418 2012
44
The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol. 61
22298226 2012
45
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. 61
22737576 2012
46
Decrease in incidence of bronchopulmonary dysplasia with erythropoietin administration in preterm infants: a retrospective study. 61
22922736 2012
47
[Incidence and risk factors of bronchopulmonary dysplasia in premature infants in 10 hospitals in China]. 61
22176899 2011
48
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. 61
21199970 2011
49
[Erythropoietin and neuroprotection]. 61
20728813 2010
50
Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. 61
20113454 2010

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

GO Terms for Anemia of Prematurity

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.32 EPO CSF2
2 acute-phase response GO:0006953 9.26 HAMP EPO
3 positive regulation of Ras protein signal transduction GO:0046579 9.16 EPOR EPO
4 response to vitamin A GO:0033189 8.96 HAMP EPO
5 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPOR EPO

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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