MCID: ANM001
MIFTS: 43

Anemia of Prematurity

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD9CM 36 776.6
NCIt 51 C97167
SNOMED-CT 69 47100003
ICD10 34 P61.2
UMLS 74 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and acquired polycythemia. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Darbepoetin alfa and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and myeloid, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 77 Anemia of prematurity refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.3 CSF3 EPO EPOR HAMP IL3
2 acquired polycythemia 10.4 EPO EPOR
3 seborrheic infantile dermatitis 10.3 CSF2 IL3
4 erythrocytosis, familial, 2 10.3 EPO EPOR
5 transient erythroblastopenia of childhood 10.3 EPO KITLG
6 retinitis pigmentosa and erythrocytic microcytosis 10.3 EPO IL3
7 neonatal anemia 10.3 EPO EPOR
8 acute monoblastic leukemia 10.3 CSF2 EPO
9 large granular lymphocyte leukemia 10.2 CSF2 STAT5B
10 thrombocytosis 10.2 CSF2 EPO IL3
11 primary polycythemia 10.2 EPO EPOR IL3
12 erythroleukemia, familial 10.2 EPO EPOR
13 megakaryocytic leukemia 10.1 CSF2 IL3 KITLG
14 refractory anemia 10.1 EPO IL3
15 b cell linker protein deficiency 10.1 STAT5A STAT5B
16 acute radiation syndrome 10.1 CSF3 EPO
17 human t-cell leukemia virus type 2 10.1 CSF2 STAT5A
18 cellular congenital mesoblastic nephroma 10.0 STAT5A STAT5B
19 jak3-deficient severe combined immunodeficiency 10.0 STAT5A STAT5B
20 engraftment syndrome 10.0 CSF2 CSF3
21 trichosporonosis 10.0 CSF2 CSF3
22 fetal erythroblastosis 10.0 EPO GYPA
23 doxorubicin induced cardiomyopathy 9.9 CSF3 EPOR
24 severe combined immunodeficiency 9.9 IL3 KITLG STAT5B
25 neutropenia 9.9 CSF2 CSF3 IL3
26 felty syndrome 9.9 CSF2 CSF3 IL3
27 diamond-blackfan anemia 9.9 CSF2 EPO EPOR IL3 KITLG
28 granulocytopenia 9.9 CSF2 CSF3 IL3
29 leukocyte disease 9.8 CSF2 CSF3 IL3
30 pancytopenia 9.7 CSF2 CSF3 EPO IL3
31 ewing's family of tumors 9.7 CSF3 EPO EPOR KITLG
32 polycythemia 9.7 EPO EPOR IL3 KITLG STAT5A
33 enterocolitis 9.7
34 chylomicron retention disease 9.7
35 bronchopulmonary dysplasia 9.7
36 hemolytic anemia 9.7
37 iron deficiency anemia 9.7
38 iron metabolism disease 9.7
39 ischemia 9.7
40 perinatal necrotizing enterocolitis 9.7
41 polycythemia vera 9.7 EPO EPOR IL3 KITLG STAT5A
42 cyclic neutropenia 9.7 CSF2 CSF3 IL3 KITLG
43 erythrocytosis, familial, 1 9.7 EPO EPOR IL3 STAT5A STAT5B
44 essential thrombocythemia 9.7 EPO EPOR IL3 STAT5A STAT5B
45 severe congenital neutropenia 9.7 CSF2 CSF3 IL3 KITLG
46 aplastic anemia 9.5 CSF2 CSF3 EPO IL3 KITLG
47 malaria 9.3 CSF2 CSF3 EPO GYPA HAMP SLC4A1
48 myelofibrosis 9.3 CSF3 EPO IL3 STAT5A STAT5B
49 hematologic cancer 9.1 CSF2 CSF3 IL3 KITLG STAT5A STAT5B
50 leukemia, chronic myeloid 9.0 CSF2 CSF3 EPO IL3 KITLG STAT5A

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 CSF2 EPO EPOR GPX3 KITLG PTGDR
2 hematopoietic system MP:0005397 10.14 CSF2 CSF3 EPO EPOR GPX3 KITLG
3 cellular MP:0005384 10.09 CSF2 EPO EPOR KITLG SCO2 SLC4A1
4 cardiovascular system MP:0005385 10.06 CSF2 EPO EPOR GPX3 KITLG PTGDR
5 immune system MP:0005387 10.02 CSF2 CSF3 EPO EPOR KITLG PTGDR
6 integument MP:0010771 9.91 CSF2 CSF3 EPO KITLG PTGDR SLC4A1
7 liver/biliary system MP:0005370 9.7 EPO EPOR KITLG SCO2 STAB2 STAT5A
8 mortality/aging MP:0010768 9.7 CSF2 EPO EPOR GPX3 KITLG PTGDR
9 renal/urinary system MP:0005367 9.1 CSF2 CSF3 GPX3 SLC4A1 STAB2 STAT5B

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2, 11096-26-7
2 Epoetin alfa Phase 1, Phase 2,Phase 2,Not Applicable 113427-24-0
3 Pharmaceutical Solutions Phase 1, Phase 2
4 Hematinics Phase 1, Phase 2,Phase 2,Not Applicable
5
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925
6 Antioxidants Not Applicable
7 Micronutrients Not Applicable
8 Trace Elements Not Applicable
9 Nutrients Not Applicable
10 Protective Agents Not Applicable
11 Iron Supplement Not Applicable
12 Anti-Infective Agents
13 Hepcidins

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants Completed NCT01393496 Phase 4
2 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
3 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
4 Darbepoetin Administration to Preterm Infants Completed NCT00334737 Phase 2 Darbepoetin Alfa Injection;erythropoietin alfa injection;sham injection
5 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
6 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
7 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
8 The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants Completed NCT00167388 Phase 1
9 Autologous Umbilical Cord Blood Transfusion for Preterm Neonates Withdrawn NCT01121328 Phase 1
10 Autologous Cord Blood Transfusion in Preterm Infants Completed NCT02101086 Not Applicable
11 Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions Completed NCT02535208 Not Applicable
12 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
13 Erythropoietin Treatment in Extremely Low Birth Weight Infants Completed NCT00593801 Not Applicable epoetin beta;epoetin beta
14 Early Versus Late Enteral Iron in Infants Less Than 1301 Grams Completed NCT00458068 Not Applicable Oral administration of ferrous sulphate
15 Hepcidin Levels in Preterm Infants Completed NCT01539356
16 Neurodevelopment After Early Iron Supplementation Completed NCT00457990 Not Applicable Oral administration of ferrous sulphate
17 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

42
Brain, Neutrophil, Myeloid, Heart, Bone, Bone Marrow, T Cells

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 102)
# Title Authors Year
1
Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? ( 29740185 )
2018
2
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. ( 29535446 )
2018
3
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. ( 28783992 )
2018
4
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. ( 23521158 )
2013
5
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. ( 23540189 )
2012
6
Erythropoietin in anemia of prematurity. ( 23025776 )
2012
7
Necrotizing enterocolitis and the role of anemia of prematurity. ( 22818548 )
2012
8
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. ( 22737576 )
2012
9
Sucking improvement following blood transfusion for anemia of prematurity. ( 22664924 )
2012
10
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? ( 20303035 )
2010
11
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. ( 19816209 )
2009
12
Current controversies in the management of the anemia of prematurity. ( 19167579 )
2009
13
Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity. ( 20463861 )
2008
14
A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. ( 18507748 )
2008
15
A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. ( 16818564 )
2006
16
Controversies in the management of the anemia of prematurity using single-donor red blood cell transfusions and/or recombinant human erythropoietin. ( 16373186 )
2006
17
Effects of transfusion in anemia of prematurity. ( 16166047 )
2005
18
Erythropoietin in anemia of prematurity. ( 12785302 )
2003
19
Iron status and the treatment of the anemia of prematurity. ( 12168242 )
2002
20
Does early erythropoietin therapy decrease transfusions in anemia of prematurity? ( 12061670 )
2002
21
Human recombinant erythropoietin in the prevention and treatment of anemia of prematurity. ( 11888358 )
2002
22
Anemia of prematurity. ( 12144218 )
2001
23
The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity. ( 11533837 )
2001
24
Managing the anemia of prematurity: red blood cell transfusions versus recombinant erythropoietin. ( 11471123 )
2001
25
Meta-analysis of controlled clinical trials studying the efficacy of rHuEPO in reducing blood transfusions in the anemia of prematurity. ( 11274599 )
2001
26
[The effect of recombinant human erythropoietin on the treatment of anemia of prematurity] ( 14647595 )
2001
27
[Prophylaxis of anemia of prematurity with erythropoietin. Case control study]. ( 11083968 )
2000
28
Recombinant human erythropoietin in anemia of prematurity. ( 10709119 )
1999
29
Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial. ( 10428996 )
1999
30
Erythropoietin to prevent and treat the anemia of prematurity. ( 10202619 )
1999
31
Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial. ( 9659643 )
1998
32
The use of erythropoietin in treatment of anemia of prematurity. ( 9601351 )
1998
33
Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia. ( 9580761 )
1998
34
Recombinant human erythropoietin as a treatment for anemia of prematurity. ( 9451192 )
1997
35
Recombinant erythropoietin for the anemia of prematurity: still a promise, not a panacea. ( 9403639 )
1997
36
The role of erythropoietin in the anemia of prematurity. ( 9190030 )
1997
37
Erythropoietin to treat anemia of prematurity. ( 9161667 )
1997
38
[Randomized multi-center trial of the administration of erythropoietin in anemia of prematurity]. ( 9297428 )
1997
39
Do cardiac output and serum lactate levels indicate blood transfusion requirements in anemia of prematurity? ( 8796405 )
1996
40
Erythropoietin therapy for anemia of prematurity. ( 8772909 )
1996
41
Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity. ( 8618185 )
1996
42
Pathophysiology and treatment of the anemia of prematurity. ( 7743231 )
1995
43
Use of epoetin (erythropoietin) in the anemia of prematurity. ( 7747503 )
1995
44
Erythropoietin--not yet a standard treatment for anemia of prematurity. ( 7770317 )
1995
45
Potential for treatment of anemia of prematurity with recombinant human erythropoietin. ( 7787927 )
1995
46
A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity. ( 8604492 )
1995
47
Recombinant human erythropoietin in the treatment of anemia of prematurity. ( 8540930 )
1995
48
The effect of recombinant human erythropoietin in treating the anemia of prematurity. ( 7793277 )
1995
49
Follow-up of very low birth weight infants after erythropoietin treatment to prevent anemia of prematurity. ( 7636658 )
1995
50
[Evaluation of treatment results for anemia of prematurity treated with various doses of human recombinant erythropoietin]. ( 8657506 )
1995

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

Pathways related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.19 CSF2 CSF3 EPOR IL3 KITLG STAT5A
2
Show member pathways
13.16 CSF2 CSF3 IL3 KITLG STAT5A STAT5B
3
Show member pathways
12.78 CSF3 EPO EPOR IL3 KITLG
4 12.63 EPO EPOR IL3 KITLG STAT5A STAT5B
5 12.35 IL3 KITLG STAT5A STAT5B
6
Show member pathways
12.17 CSF2 CSF3 EPO EPOR IL3 STAT5A
7
Show member pathways
12.01 EPO EPOR IL3 KITLG STAT5A STAT5B
8
Show member pathways
11.76 IL3 STAT5A STAT5B
9 11.71 EPO EPOR IL3 STAT5A STAT5B
10 11.7 CSF2 CSF3 EPO GYPA IL3 KITLG
11
Show member pathways
11.69 EPO EPOR STAT5A STAT5B
12 11.61 CSF2 STAT5A STAT5B
13 11.49 CSF2 CSF3 EPO EPOR GYPA IL3
14 11.33 EPO IL3 KITLG
15 11.1 CSF2 CSF3 IL3
16
Show member pathways
11.06 STAT5A STAT5B
17 11.04 STAT5A STAT5B
18 11.02 EPO EPOR
19 10.85 STAT5A STAT5B
20 10.85 CSF2 CSF3 EPO GYPA IL3 KITLG
21 10.81 CSF2 CSF3 EPOR IL3 KITLG

GO Terms for Anemia of Prematurity

Cellular components related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF2 CSF3 EPO GPX3 HAMP IL3
2 extracellular region GO:0005576 9.23 CSF2 CSF3 EPO EPOR GPX3 HAMP

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.74 CSF2 CSF3 HAMP
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 CSF3 IL3 KITLG
3 positive regulation of cell proliferation GO:0008284 9.63 CSF2 CSF3 EPO IL3 KITLG STAT5B
4 regulation of multicellular organism growth GO:0040014 9.58 STAT5A STAT5B
5 JAK-STAT cascade GO:0007259 9.56 STAT5A STAT5B
6 positive regulation of activated T cell proliferation GO:0042104 9.55 EPO STAT5B
7 positive regulation of Ras protein signal transduction GO:0046579 9.54 EPO KITLG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 CSF2 EPO IL3
9 response to vitamin A GO:0033189 9.52 EPO HAMP
10 embryonic hemopoiesis GO:0035162 9.51 IL3 KITLG
11 interleukin-15-mediated signaling pathway GO:0035723 9.49 STAT5A STAT5B
12 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.48 STAT5A STAT5B
13 interleukin-2-mediated signaling pathway GO:0038110 9.43 STAT5A STAT5B
14 regulation of signaling receptor activity GO:0010469 9.43 CSF2 CSF3 EPO HAMP IL3 KITLG
15 interleukin-9-mediated signaling pathway GO:0038113 9.4 STAT5A STAT5B
16 taurine metabolic process GO:0019530 9.32 STAT5A STAT5B
17 erythropoietin-mediated signaling pathway GO:0038162 9.26 EPO EPOR
18 cytokine-mediated signaling pathway GO:0019221 9.1 CSF2 CSF3 EPOR IL3 STAT5A STAT5B

Molecular functions related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 CSF2 CSF3 IL3 KITLG
2 protein disulfide oxidoreductase activity GO:0015035 9.16 SCO2 STAB2
3 cytokine activity GO:0005125 9.02 CSF2 CSF3 EPO IL3 KITLG

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....