MCID: ANM001
MIFTS: 42

Anemia of Prematurity

Categories: Fetal diseases, Blood diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD10 33 P61.2
ICD9CM 35 776.6
NCIt 50 C97167
SNOMED-CT 68 47100003
UMLS 73 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and acquired polycythemia. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Darbepoetin alfa and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and heart, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 76 Anemia of prematurity refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 28.2 CSF3 EPO EPOR HAMP IL3
2 acquired polycythemia 10.7 EPO EPOR
3 seborrheic infantile dermatitis 10.7 CSF2 IL3
4 erythrocytosis, familial, 2 10.7 EPO EPOR
5 retinitis pigmentosa and erythrocytic microcytosis 10.7 EPO IL3
6 neonatal anemia 10.6 EPO EPOR
7 transient erythroblastopenia of childhood 10.6 EPO KITLG
8 acute monoblastic leukemia 10.5 CSF2 EPO
9 large granular lymphocyte leukemia 10.5 CSF2 STAT5B
10 primary polycythemia 10.5 EPO EPOR IL3
11 thrombocytosis 10.5 CSF2 EPO IL3
12 eosinophilic gastroenteritis 10.3 CSF2 IL3
13 megakaryocytic leukemia 10.3 CSF2 IL3 KITLG
14 b cell linker protein deficiency 10.1 STAT5A STAT5B
15 cellular congenital mesoblastic nephroma 10.1 STAT5A STAT5B
16 engraftment syndrome 10.0 CSF2 CSF3
17 jak3-deficient severe combined immunodeficiency 10.0 STAT5A STAT5B
18 trichosporonosis 10.0 CSF2 CSF3
19 refractory anemia 10.0 EPO IL3
20 human t-cell leukemia virus type 2 9.9 CSF2 STAT5A
21 doxorubicin induced cardiomyopathy 9.9 CSF3 EPOR
22 diamond-blackfan anemia 9.8 CSF2 EPO EPOR IL3 KITLG
23 felty syndrome 9.8 CSF2 CSF3 IL3
24 cyclic neutropenia 9.8 CSF2 CSF3 IL3
25 enterocolitis 9.6
26 bronchopulmonary dysplasia 9.6
27 iron deficiency anemia 9.6
28 iron metabolism disease 9.6
29 ischemia 9.6
30 cerebritis 9.6
31 perinatal necrotizing enterocolitis 9.6
32 pancytopenia 9.6 CSF2 CSF3 EPO IL3
33 polycythemia 9.5 EPO EPOR IL3 KITLG STAT5A
34 ewing's family of tumors 9.5 CSF3 EPO EPOR KITLG
35 polycythemia vera 9.5 EPO EPOR IL3 KITLG STAT5A
36 erythrocytosis, familial, 1 9.4 EPO EPOR IL3 STAT5A STAT5B
37 leukocyte disease 9.4 CSF2 CSF3 IL3 KITLG
38 essential thrombocythemia 9.4 EPO EPOR IL3 STAT5A STAT5B
39 severe congenital neutropenia 9.3 CSF2 CSF3 IL3 KITLG
40 neutropenia 9.1 CSF2 CSF3 EPO IL3 KITLG
41 immune system disease 9.1 CSF2 CSF3 EPO HAMP IL3
42 aplastic anemia 9.1 CSF2 CSF3 EPO IL3 KITLG
43 asthma 8.7 CSF2 CSF3 IL3 KITLG PTGDR
44 myelofibrosis 8.7 CSF3 EPO IL3 STAT5A STAT5B
45 malaria 8.6 CSF2 CSF3 EPO GYPA HAMP SLC4A1
46 hematologic cancer 8.2 CSF2 CSF3 IL3 KITLG STAT5A STAT5B
47 leukemia, acute myeloid 8.2 CSF2 CSF3 IL3 KITLG STAT5A STAT5B
48 leukemia, chronic myeloid 8.0 CSF2 CSF3 EPO IL3 KITLG STAT5A
49 myelodysplastic syndrome 7.9 CSF2 CSF3 EPO EPOR GYPA IL3
50 bone marrow cancer 7.7 CSF2 CSF3 EPO EPOR IL3 KITLG

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 EPOR SCO2 SLC4A1 GPX3 CSF2 HIF1AN
2 hematopoietic system MP:0005397 10.14 EPOR GPX3 CSF2 CSF3 KITLG EPO
3 cellular MP:0005384 10.13 SCO2 EPOR CSF2 HIF1AN KITLG EPO
4 cardiovascular system MP:0005385 10.11 PTGDR EPOR GPX3 CSF2 HIF1AN KITLG
5 immune system MP:0005387 10.02 EPOR CSF2 CSF3 KITLG EPO PTGDR
6 integument MP:0010771 9.91 SLC4A1 CSF2 CSF3 KITLG EPO PTGDR
7 liver/biliary system MP:0005370 9.76 EPOR SCO2 HIF1AN KITLG EPO STAT5A
8 mortality/aging MP:0010768 9.7 PTGDR SCO2 EPOR GPX3 CSF2 KITLG
9 renal/urinary system MP:0005367 9.1 GPX3 CSF2 CSF3 STAB2 STAT5B SLC4A1

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
2 Epoetin alfa Phase 2,Phase 1,Not Applicable 113427-24-0
3 Hematinics Phase 2,Phase 1,Not Applicable
4 Pharmaceutical Solutions Phase 1, Phase 2
5
Benzocaine Approved, Investigational Phase 1 1994-09-7, 94-09-7 2337
6 tannic acid Approved, Nutraceutical Phase 1
7 Disinfectants Phase 1
8
Iron Approved Not Applicable 7439-89-6 23925
9 Antioxidants Not Applicable
10 Micronutrients Not Applicable
11 Protective Agents Not Applicable
12 Trace Elements Not Applicable
13 Anti-Infective Agents
14 Hepcidins
15 Iron Supplement Nutraceutical Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants Active, not recruiting NCT01393496 Phase 4
2 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
3 Darbepoetin Administration to Preterm Infants Unknown status NCT00334737 Phase 2 darbepoetin alfa;erythropoietin;sham injection
4 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
5 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
6 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
7 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
8 Autologous Umbilical Cord Blood Transfusion for Preterm Neonates Unknown status NCT01121328 Phase 1
9 The Effect of Blood Transfusion on Blood Flow to the Intestines of Premature Infants Completed NCT00167388 Phase 1
10 Autologous Cord Blood Transfusion in Preterm Infants Completed NCT02101086 Not Applicable
11 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
12 Erythropoietin Treatment in Extremely Low Birth Weight Infants Completed NCT00593801 Not Applicable epoetin beta;epoetin beta
13 Early Versus Late Enteral Iron in Infants Less Than 1301 Grams Completed NCT00458068 Not Applicable Oral administration of ferrous sulphate
14 Hepcidin Levels in Preterm Infants Completed NCT01539356
15 Neurodevelopment After Early Iron Supplementation Completed NCT00457990 Not Applicable Oral administration of ferrous sulphate
16 Combining Restrictive Guidelines and a NIRS SCORE to Decrease RBC Transfusions Recruiting NCT02535208 Not Applicable
17 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

41
Brain, Neutrophil, Heart

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 100)
# Title Authors Year
1
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. ( 29535446 )
2018
2
Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? ( 29740185 )
2018
3
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. ( 28783992 )
2017
4
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. ( 23521158 )
2013
5
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. ( 22737576 )
2012
6
Necrotizing enterocolitis and the role of anemia of prematurity. ( 22818548 )
2012
7
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. ( 23540189 )
2012
8
Sucking improvement following blood transfusion for anemia of prematurity. ( 22664924 )
2012
9
Erythropoietin in anemia of prematurity. ( 23025776 )
2012
10
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? ( 20303035 )
2010
11
Current controversies in the management of the anemia of prematurity. ( 19167579 )
2009
12
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. ( 19816209 )
2009
13
Pathophysiology of Anemia During the Neonatal Period, Including Anemia of Prematurity. ( 20463861 )
2008
14
A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity. ( 18507748 )
2008
15
Controversies in the management of the anemia of prematurity using single-donor red blood cell transfusions and/or recombinant human erythropoietin. ( 16373186 )
2006
16
A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. ( 16818564 )
2006
17
Effects of transfusion in anemia of prematurity. ( 16166047 )
2005
18
Erythropoietin in anemia of prematurity. ( 12785302 )
2003
19
Human recombinant erythropoietin in the prevention and treatment of anemia of prematurity. ( 11888358 )
2002
20
Does early erythropoietin therapy decrease transfusions in anemia of prematurity? ( 12061670 )
2002
21
Iron status and the treatment of the anemia of prematurity. ( 12168242 )
2002
22
[The effect of recombinant human erythropoietin on the treatment of anemia of prematurity] ( 14647595 )
2001
23
Managing the anemia of prematurity: red blood cell transfusions versus recombinant erythropoietin. ( 11471123 )
2001
24
Anemia of prematurity. ( 12144218 )
2001
25
The role of high-dose oral iron supplementation during erythropoietin therapy for anemia of prematurity. ( 11533837 )
2001
26
Meta-analysis of controlled clinical trials studying the efficacy of rHuEPO in reducing blood transfusions in the anemia of prematurity. ( 11274599 )
2001
27
[Prophylaxis of anemia of prematurity with erythropoietin. Case control study]. ( 11083968 )
2000
28
Erythropoietin to prevent and treat the anemia of prematurity. ( 10202619 )
1999
29
Recombinant human erythropoietin in anemia of prematurity. ( 10709119 )
1999
30
Financial impact of the introduction of erythropoietin in the treatment of anemia of premature infants in Israel. ( 10731302 )
1999
31
Comparison between two and five doses a week of recombinant human erythropoietin for anemia of prematurity: a randomized trial. ( 10428996 )
1999
32
Myocardial, erythropoietic, and metabolic adaptations to anemia of prematurity in infants with bronchopulmonary dysplasia. ( 9580761 )
1998
33
The use of erythropoietin in treatment of anemia of prematurity. ( 9601351 )
1998
34
Recombinant human erythropoietin therapy for treatment of anemia of prematurity in very low birth weight infants: a randomized, double-blind, placebo-controlled trial. ( 9659643 )
1998
35
The role of erythropoietin in the anemia of prematurity. ( 9190030 )
1997
36
Erythropoietin to treat anemia of prematurity. ( 9161667 )
1997
37
Recombinant human erythropoietin as a treatment for anemia of prematurity. ( 9451192 )
1997
38
[Randomized multi-center trial of the administration of erythropoietin in anemia of prematurity]. ( 9297428 )
1997
39
Recombinant erythropoietin for the anemia of prematurity: still a promise, not a panacea. ( 9403639 )
1997
40
Erythropoietin therapy for anemia of prematurity. ( 8772909 )
1996
41
Effect of protein intake on erythropoiesis during erythropoietin treatment of anemia of prematurity. ( 8618185 )
1996
42
Do cardiac output and serum lactate levels indicate blood transfusion requirements in anemia of prematurity? ( 8796405 )
1996
43
Pathophysiology and treatment of the anemia of prematurity. ( 7743231 )
1995
44
Use of epoetin (erythropoietin) in the anemia of prematurity. ( 7747503 )
1995
45
[Effects of recombinant human erythropoietin in the treatment of anemia of prematurity]. ( 7739926 )
1995
46
The effect of recombinant human erythropoietin in treating the anemia of prematurity. ( 7793277 )
1995
47
[Evaluation of treatment results for anemia of prematurity treated with various doses of human recombinant erythropoietin]. ( 8657506 )
1995
48
Potential for treatment of anemia of prematurity with recombinant human erythropoietin. ( 7787927 )
1995
49
Recombinant human erythropoietin in the treatment of anemia of prematurity. ( 8540930 )
1995
50
A cost analysis comparing erythropoietin and red cell transfusions in the treatment of anemia of prematurity. ( 8604492 )
1995

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

Pathways related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 CSF2 CSF3 EPOR IL3 KITLG STAT5A
2
Show member pathways
13.15 CSF2 CSF3 IL3 KITLG STAT5A STAT5B
3
Show member pathways
12.76 CSF3 EPO EPOR IL3 KITLG
4 12.63 EPO EPOR IL3 KITLG STAT5A STAT5B
5
Show member pathways
12.4 CSF2 CSF3 EPO EPOR IL3 STAT5A
6 12.34 IL3 KITLG STAT5A STAT5B
7
Show member pathways
12.01 EPO EPOR IL3 KITLG STAT5A STAT5B
8
Show member pathways
11.76 IL3 STAT5A STAT5B
9 11.71 EPO EPOR IL3 STAT5A STAT5B
10 11.7 CSF2 CSF3 EPO GYPA IL3 KITLG
11
Show member pathways
11.69 EPO EPOR STAT5A STAT5B
12 11.6 CSF2 STAT5A STAT5B
13 11.49 CSF2 CSF3 EPO EPOR GYPA IL3
14 11.33 EPO IL3 KITLG
15 11.11 CSF2 CSF3 IL3
16 10.85 CSF2 CSF3 EPO GYPA IL3 KITLG
17 10.83 STAT5A STAT5B

GO Terms for Anemia of Prematurity

Cellular components related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF2 CSF3 EPO GPX3 HAMP IL3
2 extracellular region GO:0005576 9.23 CSF2 CSF3 EPO EPOR GPX3 HAMP

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.8 CSF2 CSF3 HAMP
2 peptidyl-tyrosine phosphorylation GO:0018108 9.78 CSF2 IL3 STAT5A STAT5B
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 CSF3 IL3 KITLG
4 positive regulation of cell proliferation GO:0008284 9.73 CSF2 CSF3 EPO IL3 KITLG STAT5B
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 CSF2 EPO IL3
6 positive regulation of activated T cell proliferation GO:0042104 9.63 EPO STAT5B
7 regulation of signaling receptor activity GO:0010469 9.63 CSF2 CSF3 EPO HAMP IL3 KITLG
8 response to vitamin A GO:0033189 9.62 EPO HAMP
9 positive regulation of Ras protein signal transduction GO:0046579 9.62 EPO KITLG
10 2-oxoglutarate metabolic process GO:0006103 9.61 STAT5A STAT5B
11 embryonic hemopoiesis GO:0035162 9.61 IL3 KITLG
12 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.6 STAT5A STAT5B
13 interleukin-15-mediated signaling pathway GO:0035723 9.59 STAT5A STAT5B
14 oxaloacetate metabolic process GO:0006107 9.58 STAT5A STAT5B
15 creatine metabolic process GO:0006600 9.57 STAT5A STAT5B
16 interleukin-2-mediated signaling pathway GO:0038110 9.56 STAT5A STAT5B
17 succinate metabolic process GO:0006105 9.55 STAT5A STAT5B
18 citrate metabolic process GO:0006101 9.52 STAT5A STAT5B
19 valine metabolic process GO:0006573 9.51 STAT5A STAT5B
20 taurine metabolic process GO:0019530 9.49 STAT5A STAT5B
21 erythropoietin-mediated signaling pathway GO:0038162 9.46 EPO EPOR
22 creatinine metabolic process GO:0046449 9.43 STAT5A STAT5B
23 cytokine-mediated signaling pathway GO:0019221 9.43 CSF2 CSF3 EPOR IL3 STAT5A STAT5B
24 isoleucine metabolic process GO:0006549 9.4 STAT5A STAT5B
25 neutrophil differentiation GO:0030223 9.37 CSF2 CSF3
26 allantoin metabolic process GO:0000255 9.32 STAT5A STAT5B
27 positive regulation of DNA replication GO:0045740 8.92 CSF2 EPO IL3 KITLG

Molecular functions related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.46 CSF2 IL3 STAT5A STAT5B
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL3 KITLG
3 protein disulfide oxidoreductase activity GO:0015035 9.32 SCO2 STAB2
4 growth factor activity GO:0008083 9.26 CSF2 CSF3 IL3 KITLG
5 cytokine activity GO:0005125 9.02 CSF2 CSF3 EPO IL3 KITLG

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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