MCID: ANM001
MIFTS: 31

Anemia of Prematurity

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD9CM 34 776.6
NCIt 49 C97167
SNOMED-CT 67 47100003
ICD10 32 P61.2
UMLS 71 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and iron metabolism disease. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Hematopoietic Stem Cell Differentiation. The drugs Pharmaceutical Solutions and Iron have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and heart, and related phenotype is respiratory system.

Wikipedia : 74 Anemia of prematurity (AOP) refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 30.5 HAMP EPOR EPO CSF2
2 iron metabolism disease 30.1 HAMP EPO
3 hemosiderosis 29.6 HAMP EPO
4 iron deficiency anemia 29.1 HAMP EPO
5 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.3 EPO CSF2
6 acute monoblastic leukemia 10.3 EPO CSF2
7 erythroleukemia, familial 10.2 EPOR EPO
8 hypersplenism 10.2 EPO CSF2
9 erythrocytosis, familial, 2 10.2 EPOR EPO
10 pure red-cell aplasia 10.2 EPOR EPO
11 erythrocytosis, familial, 1 10.2 EPOR EPO
12 primary polycythemia 10.2 EPOR EPO
13 neonatal anemia 10.0 LINC-PINT EPOR EPO
14 exudative vitreoretinopathy 1 10.0 LINC-PINT EPOR EPO
15 congenital dyserythropoietic anemia 10.0 HAMP EPO
16 ocular hypertension 10.0 EPOR EPO
17 enterocolitis 10.0
18 perinatal necrotizing enterocolitis 10.0
19 essential thrombocythemia 10.0 EPOR EPO CSF2
20 myeloproliferative neoplasm 10.0 EPOR EPO CSF2
21 hemoglobin h disease 10.0 HAMP EPO
22 microcytic anemia 9.9 HAMP EPO
23 neutropenia 9.9
24 hemolytic anemia 9.9
25 diamond-blackfan anemia 9.9 EPOR EPO CSF2
26 acquired polycythemia 9.9 HAMP EPOR EPO
27 polycythemia 9.9 HAMP EPOR EPO
28 hemoglobinopathy 9.8 HAMP EPO
29 chylomicron retention disease 9.7
30 sudden infant death syndrome 9.7
31 yemenite deaf-blind hypopigmentation syndrome 9.7
32 patent ductus arteriosus 1 9.7
33 hemorrhagic disease 9.7
34 thrombocytosis 9.7
35 ischemia 9.7
36 end stage renal failure 9.7
37 bronchopulmonary dysplasia 9.7
38 rare hereditary hemochromatosis 9.7
39 polycythemia vera 9.6 HAMP EPOR EPO CSF2
40 myelodysplastic syndrome 9.6 HAMP EPOR EPO CSF2

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 CSF2 EPO EPOR PDS5B PTGDR STAB2

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4
2
Iron Approved, Experimental Phase 2, Phase 3 7439-89-6, 15438-31-0 23925 27284
3 Hematinics Phase 2, Phase 3
4 Epoetin alfa Phase 2, Phase 3 113427-24-0
5 Iron-Dextran Complex Phase 2, Phase 3
6 Dextrans Phase 2, Phase 3
7
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2, 11096-26-7

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants (ETTNO)- a Blinded Randomized Controlled Multicenter Trial Completed NCT01393496 Phase 4
2 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
3 Effect of Early Application of Recombinant Human Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Unknown status NCT03110341 Phase 3 Erythropoietin;Normal saline
4 A Randomized Controlled Trial of Two Hemoglobin Thresholds for Transfusion in Newborns <1000g Birth Weight Completed NCT00182390 Phase 3
5 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Preterm Infants 401-1250 Grams: Two Multi-Center, Randomized, Double-Masked, Placebo Controlled Studies Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
6 Early Treatment With Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants: Comparison of High and Low Dose Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
7 A Randomized, Masked, Placebo Controlled Study to Assess the Safety and Efficacy of Darbepoetin Alfa Administered to Preterm Infants Completed NCT00334737 Phase 2 Darbepoetin Alfa Injection;erythropoietin alfa injection;sham injection
8 A Randomized, Masked Study of Weekly Erythropoietin Dosing in Preterm Infants Completed NCT01235923 Phase 2 three times weekly Epo;weekly Epo
9 Effect of Erythropoietin on Neonatal Hypoxic Ischemic Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
10 High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
11 Safety and Effectiveness Phase 1 Study of Autologous Umbilical Cord Blood Transfusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
12 The Effect of Packed Red Blood Cell Transfusion on Superior Mesenteric Artery Blood Flow Velocity in Premature Infants After Feeding Completed NCT00167388 Phase 1
13 Evaluation of the Efficacy and Safety of Autologous Cord Blood Transfusions in Premature Infants Completed NCT02101086
14 A Pilot Randomized Trial of Restrictive Red Blood Cell Transfusion Guidelines Used in Combination With Near-infrared Spectroscopy Splanchnic-cerebral Oxygenation Ratio Evaluations Versus Liberal Red Blood Cell Transfusion Guidelines in Preterm Infants Completed NCT02535208
15 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
16 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates. Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

40
Brain, Neutrophil, Heart, Myeloid

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 216)
# Title Authors PMID Year
1
The development of intestinal dysbiosis in anemic preterm infants. 61
31992818 2020
2
Anemia of Prematurity and Oral Feeding Milestones in Premature Infants. 61
31777047 2019
3
The role of recombinant Human erythropoietin in neonatal anemia. 61
31628923 2019
4
Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction. 61
31669878 2019
5
Liberal hemoglobin threshold affects cerebral arterial pulsed Doppler and cardiac output, not cerebral tissue oxygenation: a prospective cohort study in anemic preterm infants. 61
31313334 2019
6
Updates in Red Blood Cell and Platelet Transfusions in Preterm Neonates. 61
31238357 2019
7
[Clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia: multicenter retrospective analysis]. 61
30630229 2019
8
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. 61
28783992 2018
9
Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates. 61
30178874 2018
10
Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? 61
29740185 2018
11
Comparison of Placental and Neonatal Admission Complete Blood Cell Count and Blood Cultures. 61
29578894 2018
12
Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis. 61
29767696 2018
13
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. 61
29535446 2018
14
Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants. 61
27346390 2017
15
[Focus on placental transfusion for preterm neonates: Delayed cord clamping and/or milking?] 61
27638229 2016
16
[Decreased transfusions in preterm infants with anemia treated with erythropoietin]. 61
27428338 2016
17
Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units. 61
26341125 2015
18
Diffuse neonatal hemangiomatosis in a very low-birthweight infant treated with erythropoietin. 61
25868957 2015
19
Immediate compared with delayed cord clamping in the preterm neonate: a randomized controlled trial. 61
25415157 2014
20
Measurement of posttransfusion red cell survival with the biotin label. 61
24969019 2014
21
Red blood cell transfusion in newborn infants. 61
24855419 2014
22
Evaluation of a new restricted transfusion protocol in neonates admitted to the NICU. 61
25678998 2014
23
Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants. 61
24135784 2014
24
[Clinical study of iron protein succinylate oral solution for preventing and treating anemia of prematurity]. 61
24342196 2013
25
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. 61
23521158 2013
26
Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. 61
24088873 2013
27
Preterm infant with a late presentation of blueberry muffin lesions secondary to recombinant erythropoietin. 61
24050292 2013
28
The effect of blood transfusion on cerebral hemodynamics in preterm infants. 61
23145971 2013
29
Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin. 61
23485870 2013
30
Risk factors of transfusion in anemia of very low birth weight infants. 61
23364969 2013
31
[Blood transfusions suppress erythropoiesis in anemia of prematurity]. 61
24501868 2013
32
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. 61
23540189 2012
33
Sucking improvement following blood transfusion for anemia of prematurity. 61
22664924 2012
34
Erythropoietin in anemia of prematurity. 61
23025776 2012
35
Late-onset blueberry muffin lesions following recombinant erythropoietin administration in a premature infant. 61
23007340 2012
36
Necrotizing enterocolitis and the role of anemia of prematurity. 61
22818548 2012
37
[Discussion on the clinical indications for blood transfusion in anemia of prematurity]. 61
22967418 2012
38
The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol. 61
22298226 2012
39
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. 61
22737576 2012
40
Decrease in incidence of bronchopulmonary dysplasia with erythropoietin administration in preterm infants: a retrospective study. 61
22922736 2012
41
[Incidence and risk factors of bronchopulmonary dysplasia in premature infants in 10 hospitals in China]. 61
22176899 2011
42
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. 61
21199970 2011
43
[Erythropoietin and neuroprotection]. 61
20728813 2010
44
Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. 61
20113454 2010
45
A rational approach to red blood cell transfusion in the neonatal ICU. 61
20087187 2010
46
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? 61
20303035 2010
47
Thrombocytosis in neonates and young infants: a report of 25 patients with platelet counts of > or = 1000000 microl(-1). 61
19798040 2010
48
Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity. 61
20102705 2010
49
[Does human recombinant erythropoetin /R-HU-EPO/ treatment for anemia of prematurity have any effect on reducing the number of blood transfusions?]. 61
20734672 2010
50
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. 61
19816209 2009

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

GO Terms for Anemia of Prematurity

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.26 HAMP EPO
2 positive regulation of Ras protein signal transduction GO:0046579 9.16 EPOR EPO
3 response to vitamin A GO:0033189 8.96 HAMP EPO
4 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPOR EPO

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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