MCID: ANM001
MIFTS: 38

Anemia of Prematurity

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Anemia of Prematurity

MalaCards integrated aliases for Anemia of Prematurity:

Name: Anemia of Prematurity 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11243
ICD9CM 35 776.6
NCIt 50 C97167
SNOMED-CT 68 47100003
ICD10 33 P61.2
UMLS 72 C0158996

Summaries for Anemia of Prematurity

MalaCards based summary : Anemia of Prematurity is related to deficiency anemia and thrombocytosis. An important gene associated with Anemia of Prematurity is EPO (Erythropoietin), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Pharmaceutical Solutions and Iron have been mentioned in the context of this disorder. Affiliated tissues include brain, neutrophil and heart, and related phenotypes are hematopoietic system and cellular

Wikipedia : 75 Anemia of prematurity (AOP) refers to a form of anemia affecting preterm infants with decreased... more...

Related Diseases for Anemia of Prematurity

Diseases related to Anemia of Prematurity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 30.4 IL3 HAMP EPOR EPO CSF3
2 thrombocytosis 30.2 IL3 EPO CSF2
3 neutropenia 30.1 IL3 CSF3 CSF2
4 acquired polycythemia 10.6 EPOR EPO
5 seborrheic infantile dermatitis 10.6 IL3 CSF2
6 transient erythroblastopenia of childhood 10.5 KITLG EPO
7 erythrocytosis, familial, 2 10.5 EPOR EPO
8 retinitis pigmentosa and erythrocytic microcytosis 10.5 IL3 EPO
9 large granular lymphocyte leukemia 10.5 STAT5B CSF2
10 acute monoblastic leukemia 10.4 EPO CSF2
11 primary polycythemia 10.4 IL3 EPOR EPO
12 neonatal anemia 10.4 EPOR EPO
13 acute radiation syndrome 10.3 EPO CSF3
14 megakaryocytic leukemia 10.3 KITLG IL3 CSF2
15 engraftment syndrome 10.2 CSF3 CSF2
16 refractory anemia 10.2 IL3 EPO
17 trichosporonosis 10.2 CSF3 CSF2
18 doxorubicin induced cardiomyopathy 10.1 EPOR CSF3
19 erythroleukemia, familial 10.1 EPOR EPO
20 felty syndrome 10.0 IL3 CSF3 CSF2
21 iron metabolism disease 10.0
22 granulocytopenia 10.0 IL3 CSF3 CSF2
23 leukocyte disease 10.0 IL3 CSF3 CSF2
24 enterocolitis 10.0
25 perinatal necrotizing enterocolitis 10.0
26 diamond-blackfan anemia 9.9 KITLG IL3 EPOR EPO CSF2
27 hemolytic anemia 9.9
28 pancytopenia 9.9 IL3 EPO CSF3 CSF2
29 cellular congenital mesoblastic nephroma 9.8 STAT5B STAT5A
30 ewing's family of tumors 9.8 KITLG EPOR EPO CSF3
31 jak3-deficient severe combined immunodeficiency 9.8 STAT5B STAT5A
32 cyclic neutropenia 9.8 KITLG IL3 CSF3 CSF2
33 human t-cell leukemia virus type 2 9.8 STAT5A CSF2
34 severe congenital neutropenia 9.7 KITLG IL3 CSF3 CSF2
35 chylomicron retention disease 9.7
36 sudden infant death syndrome 9.7
37 yemenite deaf-blind hypopigmentation syndrome 9.7
38 iron deficiency anemia 9.7
39 hemosiderosis 9.7
40 hemorrhagic disease 9.7
41 ischemia 9.7
42 end stage renal failure 9.7
43 bronchopulmonary dysplasia 9.7
44 rare hereditary hemochromatosis 9.7
45 aplastic anemia 9.5 KITLG IL3 EPO CSF3 CSF2
46 malaria 9.5 HAMP GYPA EPO CSF3 CSF2
47 polycythemia 9.4 STAT5A KITLG IL3 EPOR EPO
48 polycythemia vera 9.4 STAT5A KITLG IL3 EPOR EPO
49 erythrocytosis, familial, 1 9.3 STAT5B STAT5A IL3 EPOR EPO
50 essential thrombocythemia 9.3 STAT5B STAT5A IL3 EPOR EPO

Graphical network of the top 20 diseases related to Anemia of Prematurity:



Diseases related to Anemia of Prematurity

Symptoms & Phenotypes for Anemia of Prematurity

MGI Mouse Phenotypes related to Anemia of Prematurity:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.11 CLDN4 CSF2 CSF3 EPO EPOR GPX3
2 cellular MP:0005384 10.1 CLDN4 CSF2 EPO EPOR KITLG SAMHD1
3 homeostasis/metabolism MP:0005376 10.1 CLDN4 CSF2 EPO EPOR GPX3 KITLG
4 immune system MP:0005387 9.96 CSF2 CSF3 EPO EPOR KITLG PTGDR
5 integument MP:0010771 9.76 CSF2 CSF3 EPO KITLG PTGDR SLC7A11
6 liver/biliary system MP:0005370 9.5 EPO EPOR KITLG SCO2 STAB2 STAT5A
7 mortality/aging MP:0010768 9.4 CLDN4 CSF2 EPO EPOR GPX3 KITLG

Drugs & Therapeutics for Anemia of Prematurity

Drugs for Anemia of Prematurity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4
2
Iron Approved, Experimental Phase 2, Phase 3 15438-31-0, 7439-89-6 23925 27284
3 Dextrans Phase 2, Phase 3
4 Iron-Dextran Complex Phase 2, Phase 3
5 Hematinics Phase 3
6 Epoetin alfa Phase 3 113427-24-0
7
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth Weight Infants (ETTNO)- a Blinded Randomized Controlled Multicenter Trial Completed NCT01393496 Phase 4
2 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
3 A Randomized Controlled Trial of Two Hemoglobin Thresholds for Transfusion in Newborns <1000g Birth Weight Completed NCT00182390 Phase 3
4 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Preterm Infants 401-1250 Grams: Two Multi-Center, Randomized, Double-Masked, Placebo Controlled Studies Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
5 Effect of Early Application of Recombinant Human Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
6 Early Treatment With Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants: Comparison of High and Low Dose Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
7 A Randomized, Masked, Placebo Controlled Study to Assess the Safety and Efficacy of Darbepoetin Alfa Administered to Preterm Infants Completed NCT00334737 Phase 2 Darbepoetin Alfa Injection;erythropoietin alfa injection;sham injection
8 A Randomized, Masked Study of Weekly Erythropoietin Dosing in Preterm Infants Completed NCT01235923 Phase 2 three times weekly Epo;weekly Epo
9 Effect of Erythropoietin on Neonatal Hypoxic Ischemic Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
10 High-Dose Erythropoietin in Very Low Birth Weight Infants for the Potential Treatment of Prematurity-Related Cerebral Hemorrhagic-Ischemic Injury: A Phase II Safety/Tolerability Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
11 Safety and Effectiveness Phase 1 Study of Autologous Umbilical Cord Blood Transfusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
12 The Effect of Packed Red Blood Cell Transfusion on Superior Mesenteric Artery Blood Flow Velocity in Premature Infants After Feeding Completed NCT00167388 Phase 1
13 Evaluation of the Efficacy and Safety of Autologous Cord Blood Transfusions in Premature Infants Completed NCT02101086
14 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
15 A Pilot Randomized Trial of Restrictive Red Blood Cell Transfusion Guidelines Used in Combination With Near-infrared Spectroscopy Splanchnic-cerebral Oxygenation Ratio Evaluations Versus Liberal Red Blood Cell Transfusion Guidelines in Preterm Infants Completed NCT02535208
16 Transfusion-related Inflammatory Cytokine and Neutrophil Extracellular Trap Quantification in Neonates. Terminated NCT01735552

Search NIH Clinical Center for Anemia of Prematurity

Genetic Tests for Anemia of Prematurity

Anatomical Context for Anemia of Prematurity

MalaCards organs/tissues related to Anemia of Prematurity:

41
Brain, Neutrophil, Heart

Publications for Anemia of Prematurity

Articles related to Anemia of Prematurity:

(show top 50) (show all 212)
# Title Authors PMID Year
1
Updates in Red Blood Cell and Platelet Transfusions in Preterm Neonates. 38
31238357 2019
2
Liberal hemoglobin threshold affects cerebral arterial pulsed Doppler and cardiac output, not cerebral tissue oxygenation: a prospective cohort study in anemic preterm infants. 38
31313334 2019
3
[Clinical characteristics and risk factors of very low birth weight and extremely low birth weight infants with bronchopulmonary dysplasia: multicenter retrospective analysis]. 38
30630229 2019
4
Evaluation of serum ischemia-modified albumin levels in anemia of prematurity. 38
28783992 2018
5
Use of potassium adsorption filter for the removal of ammonia and potassium from red blood cell solution for neonates. 38
30178874 2018
6
Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? 38
29740185 2018
7
Comparison of Placental and Neonatal Admission Complete Blood Cell Count and Blood Cultures. 38
29578894 2018
8
Clinical Outcomes Related to the Gastrointestinal Trophic Effects of Erythropoietin in Preterm Neonates: A Systematic Review and Meta-Analysis. 38
29767696 2018
9
Tubular immaturity causes erythropoietin-deficiency anemia of prematurity in preterm neonates. 38
29535446 2018
10
Early Erythropoietin Administration does not Increase the Risk of Retinopathy in Preterm Infants. 38
27346390 2017
11
[Focus on placental transfusion for preterm neonates: Delayed cord clamping and/or milking?] 38
27638229 2016
12
[Decreased transfusions in preterm infants with anemia treated with erythropoietin]. 38
27428338 2016
13
Factors associated with red blood cell transfusions in very-low-birth-weight preterm infants in Brazilian neonatal units. 38
26341125 2015
14
Diffuse neonatal hemangiomatosis in a very low-birthweight infant treated with erythropoietin. 38
25868957 2015
15
Immediate compared with delayed cord clamping in the preterm neonate: a randomized controlled trial. 38
25415157 2014
16
Measurement of posttransfusion red cell survival with the biotin label. 38
24969019 2014
17
Red blood cell transfusion in newborn infants. 38
24855419 2014
18
Evaluation of a new restricted transfusion protocol in neonates admitted to the NICU. 38
25678998 2014
19
Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants. 38
24135784 2014
20
Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity. 38
23521158 2013
21
[Clinical study of iron protein succinylate oral solution for preventing and treating anemia of prematurity]. 38
24342196 2013
22
Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. 38
24088873 2013
23
Preterm infant with a late presentation of blueberry muffin lesions secondary to recombinant erythropoietin. 38
24050292 2013
24
The effect of blood transfusion on cerebral hemodynamics in preterm infants. 38
23145971 2013
25
Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin. 38
23485870 2013
26
Risk factors of transfusion in anemia of very low birth weight infants. 38
23364969 2013
27
[Blood transfusions suppress erythropoiesis in anemia of prematurity]. 38
24501868 2013
28
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates. 38
23540189 2012
29
Sucking improvement following blood transfusion for anemia of prematurity. 38
22664924 2012
30
Erythropoietin in anemia of prematurity. 38
23025776 2012
31
Late-onset blueberry muffin lesions following recombinant erythropoietin administration in a premature infant. 38
23007340 2012
32
Necrotizing enterocolitis and the role of anemia of prematurity. 38
22818548 2012
33
[Discussion on the clinical indications for blood transfusion in anemia of prematurity]. 38
22967418 2012
34
The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth-Weight Infants (ETTNO)' Study: Background, Aims, and Study Protocol. 38
22298226 2012
35
Comparison of oral recombinant erythropoietin and subcutaneous recombinant erythropoietin in prevention of anemia of prematurity. 38
22737576 2012
36
Decrease in incidence of bronchopulmonary dysplasia with erythropoietin administration in preterm infants: a retrospective study. 38
22922736 2012
37
[Incidence and risk factors of bronchopulmonary dysplasia in premature infants in 10 hospitals in China]. 38
22176899 2011
38
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. 38
21199970 2011
39
[Erythropoietin and neuroprotection]. 38
20728813 2010
40
Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. 38
20113454 2010
41
A rational approach to red blood cell transfusion in the neonatal ICU. 38
20087187 2010
42
Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity? 38
20303035 2010
43
Thrombocytosis in neonates and young infants: a report of 25 patients with platelet counts of > or = 1000000 microl(-1). 38
19798040 2010
44
Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity. 38
20102705 2010
45
[Does human recombinant erythropoetin /R-HU-EPO/ treatment for anemia of prematurity have any effect on reducing the number of blood transfusions?]. 38
20734672 2010
46
Erythrocyte transfusions and serum prohepcidin levels in premature newborns with anemia of prematurity. 38
19816209 2009
47
Post-discharge supplementation of vitamins and minerals for preterm neonates. 38
19767157 2009
48
Anemia in the preterm infant: erythropoietin versus erythrocyte transfusion--it's not that simple. 38
19161869 2009
49
Current controversies in the management of the anemia of prematurity. 38
19167579 2009
50
[Prevention of anemia of prematurity]. 38
20225493 2009

Variations for Anemia of Prematurity

Expression for Anemia of Prematurity

Search GEO for disease gene expression data for Anemia of Prematurity.

Pathways for Anemia of Prematurity

Pathways related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 STAT5B STAT5A KITLG IL3 EPOR CSF3
2
Show member pathways
13.15 STAT5B STAT5A SAMHD1 KITLG IL3 CSF3
3
Show member pathways
12.81 KITLG IL3 EPOR EPO CSF3
4 12.63 STAT5B STAT5A KITLG IL3 EPOR EPO
5 12.36 STAT5B STAT5A KITLG IL3
6
Show member pathways
12.17 STAT5B STAT5A IL3 EPOR EPO CSF3
7
Show member pathways
12.01 STAT5B STAT5A KITLG IL3 EPOR EPO
8
Show member pathways
11.77 STAT5B STAT5A IL3
9 11.71 STAT5B STAT5A IL3 EPOR EPO
10 11.7 KITLG IL3 GYPA EPO CSF3 CSF2
11
Show member pathways
11.69 STAT5B STAT5A EPOR EPO
12 11.6 STAT5B STAT5A CSF2
13 11.49 KITLG IL3 GYPA EPOR EPO CSF3
14 11.33 KITLG IL3 EPO
15 11.1 IL3 CSF3 CSF2
16 10.85 STAT5A KITLG IL3 GYPA EPO CSF3
17 10.84 STAT5B STAT5A
18 10.84 KITLG IL3 EPOR CSF3 CSF2

GO Terms for Anemia of Prematurity

Cellular components related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 KITLG IL3 HAMP GPX3 EPO CSF3
2 extracellular region GO:0005576 9.23 KITLG IL3 HAMP GPX3 EPOR EPO

Biological processes related to Anemia of Prematurity according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 SAMHD1 IL3 HAMP CSF3 CSF2
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 KITLG IL3 CSF3
3 response to vitamin A GO:0033189 9.54 HAMP EPO
4 positive regulation of Ras protein signal transduction GO:0046579 9.52 KITLG EPO
5 embryonic hemopoiesis GO:0035162 9.51 KITLG IL3
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.5 IL3 EPO CSF2
7 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.49 STAT5B STAT5A
8 interleukin-15-mediated signaling pathway GO:0035723 9.48 STAT5B STAT5A
9 interleukin-2-mediated signaling pathway GO:0038110 9.43 STAT5B STAT5A
10 interleukin-9-mediated signaling pathway GO:0038113 9.37 STAT5B STAT5A
11 positive regulation of cell proliferation GO:0008284 9.35 KITLG IL3 EPO CSF3 CSF2
12 taurine metabolic process GO:0019530 9.26 STAT5B STAT5A
13 erythropoietin-mediated signaling pathway GO:0038162 9.16 EPOR EPO
14 cytokine-mediated signaling pathway GO:0019221 9.1 STAT5B STAT5A IL3 EPOR CSF3 CSF2

Molecular functions related to Anemia of Prematurity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 KITLG IL3 CSF3 CSF2
2 protein disulfide oxidoreductase activity GO:0015035 9.16 STAB2 SCO2
3 cytokine activity GO:0005125 9.02 KITLG IL3 EPO CSF3 CSF2

Sources for Anemia of Prematurity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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