Aneruptive Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Aneruptive Fever

MalaCards integrated aliases for Aneruptive Fever:

Name: Aneruptive Fever ¹² ¹⁵

Rickettsia Helvetica Spotted Fever ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050484

Sources

Summaries for Aneruptive Fever

Disease Ontology : ¹² A spotted fever that has material basis in Rickettsia helvetica, which is transmitted by ticks (Ixodes sp). The infection has symptom fever, has symptom headache, has symptom myalgia.

MalaCards based summary : Aneruptive Fever, also known as rickettsia helvetica spotted fever, is related to exanthem and headache, and has symptoms including fever, myalgia and headache. An important gene associated with Aneruptive Fever is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. Related phenotypes are cellular and digestive/alimentary

Sources

Related Diseases for Aneruptive Fever

Diseases related to Aneruptive Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)

#	Related Disease	Score	Top Affiliating Genes
1	exanthem	10.3
2	headache	10.3
3	rare deficiency anemia	10.2	HBB FOXP3
4	trachoma	10.1	HBB FOXP3
5	macular degeneration, age-related, 8	10.1	TBX21 CD28
6	dermatitis, atopic, 8	10.1	GATA3 FOXP3
7	autoimmune disease of eyes, ear, nose and throat	10.1	TBX21 FOXP3
8	angioimmunoblastic t-cell lymphoma	10.0	TBX21 CD28
9	egg allergy	9.9	IL13 FOXP3
10	legume allergy	9.9	IL13 FOXP3
11	fruit allergy	9.9	IL13 FOXP3
12	filarial elephantiasis	9.9	IL13 FOXP3
13	paranasal sinus disease	9.9	IL13 GATA3
14	kidney papillary necrosis	9.9	HBB ALB
15	splenic infarction	9.9	HBB ALB
16	pollen allergy	9.9	IL13 FOXP3
17	hemoglobin d disease	9.9	HBB ALB
18	milk allergy	9.9	IL13 FOXP3
19	allergic conjunctivitis	9.9	IL13 FOXP3
20	chronic inflammatory demyelinating polyradiculoneuropathy	9.8	TBX21 ALB
21	conjunctivitis	9.8	IL13 FOXP3
22	polyradiculoneuropathy	9.8	TBX21 ALB
23	blood protein disease	9.8	HBB ALB
24	hypersplenism	9.8	FOXP3 ALB
25	autoimmune disease of blood	9.8	FOXP3 ALB
26	bronchiolitis obliterans	9.7	IL13 FOXP3
27	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.7	TBX21 FOXP3 CD28
28	paracoccidioidomycosis	9.7	CD28 ALB
29	cefaclor allergy	9.7	IL13 ALB
30	autoimmune pancreatitis	9.7	FOXP3 ALB
31	chronic meningitis	9.7	IL13 ALB
32	cardiomyopathy, familial hypertrophic, 20	9.7	IL13 ALB
33	sezary's disease	9.7	GATA3 FOXP3 CD28
34	lipoid nephrosis	9.7	IL13 ALB
35	conjunctival disease	9.7	IL13 ALB
36	cholelithiasis	9.7	HBB ALB
37	lymph node disease	9.7	FOXP3 ALB
38	hypersensitivity reaction type iv disease	9.6	FOXP3 ALB
39	opportunistic mycosis	9.6	IL13 ALB
40	autoimmune disease of gastrointestinal tract	9.6	FOXP3 ALB
41	dermatitis, atopic	9.6	IL13 GATA3 FOXP3
42	fungal infectious disease	9.6	IL13 ALB
43	common cold	9.6	IL13 ALB
44	allergic hypersensitivity disease	9.6	IL13 FOXP3 CD28
45	filariasis	9.6	GATA3 ALB
46	anemia, x-linked, with or without neutropenia and/or platelet abnormalities	9.5	HBB FOXP3 ALB
47	keratoconjunctivitis	9.5	IL13 ALB
48	cutaneous leishmaniasis	9.5	IL13 FOXP3
49	dengue hemorrhagic fever	9.5	IL13 ALB
50	immune deficiency disease	9.4	IL13 FOXP3 CD28

Graphical network of the top 20 diseases related to Aneruptive Fever:

Sources

Symptoms & Phenotypes for Aneruptive Fever

Symptoms:

¹²

• fever
• myalgia

• headache

MGI Mouse Phenotypes related to Aneruptive Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.73	ALB CD28 FOXP3 GATA3 IL13 TBX21
2	digestive/alimentary	MP:0005381	9.63	ALB CD28 FOXP3 GATA3 IL13 TBX21
3	endocrine/exocrine gland	MP:0005379	9.43	ALB CD28 FOXP3 GATA3 IL13 TBX21
4	immune system	MP:0005387	9.1	ALB CD28 FOXP3 GATA3 IL13 TBX21

Sources

Drugs & Therapeutics for Aneruptive Fever

Search Clinical Trials , NIH Clinical Center for Aneruptive Fever

Sources

Genetic Tests for Aneruptive Fever

Sources

Anatomical Context for Aneruptive Fever

Sources

Publications for Aneruptive Fever

Articles related to Aneruptive Fever:

#	Title	Authors	PMID	Year
1	Rickettsia helvetica in Human-Parasitizing and Free-Living Ixodes ricinus from Urban and Wild Green Areas in the Metropolitan City of Rome, Italy. ⁶¹	Scarpulla M...Macri G	29664700	2018
2	Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. ⁶¹	Fournier PE...Raoult D	14766859	2004

Sources

Genes for Aneruptive Fever

Genes related to Aneruptive Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HBB	Hemoglobin Subunit Beta	Protein Coding	4.2	DISEASES inferred ¹⁵
2	TBX21	T-Box Transcription Factor 21	Protein Coding	4.01	DISEASES inferred ¹⁵
3	GATA3	GATA Binding Protein 3	Protein Coding	3.9	DISEASES inferred ¹⁵
4	CD28	CD28 Molecule	Protein Coding	3.66	DISEASES inferred ¹⁵
5	IL13	Interleukin 13	Protein Coding	3.42	DISEASES inferred ¹⁵
6	ALB	Albumin	Protein Coding	3.34	DISEASES inferred ¹⁵
7	FOXP3	Forkhead Box P3	Protein Coding	3.29	DISEASES inferred ¹⁵

Sources

Variations for Aneruptive Fever

Sources

Expression for Aneruptive Fever

Search GEO for disease gene expression data for Aneruptive Fever.

Sources

Pathways for Aneruptive Fever

Pathways related to Aneruptive Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.14	TBX21 GATA3 FOXP3 CD28
2	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	11.89	TBX21 IL13 GATA3 FOXP3 CD28
3	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	11.66	TBX21 GATA3 CD28
4	Glucocorticoid receptor regulatory network ¹	11.52	TBX21 IL13 GATA3
5	Innate Lymphoid Cells Differentiation ⁶⁴	11.48	TBX21 IL13 GATA3
6	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.43	TBX21 GATA3 FOXP3
7	Development and heterogeneity of the ILC family ¹	10.94	TBX21 IL13 GATA3
8	IL12 signaling mediated by STAT4 ¹	10.78	TBX21 IL13 CD28
9	Th2 Differentiation ⁶⁴	10.59	IL13 GATA3 FOXP3 CD28

Sources

GO Terms for Aneruptive Fever

Biological processes related to Aneruptive Fever according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.88	TBX21 GATA3 FOXP3 CD28
2	negative regulation of gene expression	GO:0010629	9.71	GATA3 FOXP3 CD28
3	T cell receptor signaling pathway	GO:0050852	9.65	GATA3 FOXP3 CD28
4	negative regulation of inflammatory response	GO:0050728	9.61	IL13 GATA3 FOXP3
5	cellular response to cytokine stimulus	GO:0071345	9.57	IL13 GATA3
6	humoral immune response	GO:0006959	9.56	GATA3 CD28
7	T cell activation	GO:0042110	9.55	FOXP3 CD28
8	positive regulation of gene expression	GO:0010628	9.55	TBX21 IL13 GATA3 FOXP3 CD28
9	response to virus	GO:0009615	9.54	TBX21 GATA3 FOXP3
10	T cell differentiation	GO:0030217	9.52	TBX21 GATA3
11	negative regulation of endothelial cell apoptotic process	GO:2000352	9.51	IL13 GATA3
12	negative regulation of interferon-gamma production	GO:0032689	9.49	GATA3 FOXP3
13	regulation of regulatory T cell differentiation	GO:0045589	9.46	FOXP3 CD28
14	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.4	TBX21 CD28
15	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.32	TBX21 FOXP3
16	lymphocyte migration	GO:0072676	9.26	TBX21 GATA3
17	positive regulation of interleukin-4 production	GO:0032753	9.13	GATA3 FOXP3 CD28
18	negative regulation of interleukin-2 production	GO:0032703	8.8	TBX21 GATA3 FOXP3

Molecular functions related to Aneruptive Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:0019825	8.62	HBB ALB

Sources

Sources for Aneruptive Fever

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia