Aneruptive Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Aneruptive Fever

MalaCards integrated aliases for Aneruptive Fever:

Name: Aneruptive Fever ¹² ¹⁵

Rickettsia Helvetica Spotted Fever ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050484

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Summaries for Aneruptive Fever

Disease Ontology : ¹² A spotted fever that has material basis in Rickettsia helvetica, which is transmitted by ticks (Ixodes sp). The infection has symptom fever, has symptom headache, has symptom myalgia.

MalaCards based summary : Aneruptive Fever, also known as rickettsia helvetica spotted fever, is related to immunodeficiency 27b and dermatitis, atopic, 5, and has symptoms including fever, myalgia and headache. An important gene associated with Aneruptive Fever is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. Related phenotypes are cellular and digestive/alimentary

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Related Diseases for Aneruptive Fever

Diseases related to Aneruptive Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Related Disease	Score	Top Affiliating Genes
1	immunodeficiency 27b	10.1	TBX21 GATA3
2	dermatitis, atopic, 5	10.1	TBX21 GATA3
3	macular degeneration, age-related, 8	10.1	TBX21 CD28
4	dermatitis, atopic, 8	10.1	GATA3 FOXP3
5	autoimmune disease of eyes, ear, nose and throat	10.1	TBX21 FOXP3
6	exanthem	10.1
7	angioimmunoblastic t-cell lymphoma	10.0	TBX21 CD28
8	dacryoadenitis	10.0	IL13 FOXP3
9	egg allergy	10.0	IL13 FOXP3
10	filarial elephantiasis	10.0	IL13 FOXP3
11	legume allergy	10.0	IL13 FOXP3
12	fruit allergy	10.0	IL13 FOXP3
13	kidney papillary necrosis	10.0	HBB ALB
14	hemoglobin d disease	10.0	HBB ALB
15	splenic infarction	10.0	HBB ALB
16	paranasal sinus disease	10.0	IL13 GATA3
17	pollen allergy	10.0	IL13 FOXP3
18	milk allergy	9.9	IL13 FOXP3
19	glucosephosphate dehydrogenase deficiency	9.9	HBB ALB
20	allergic conjunctivitis	9.9	IL13 FOXP3
21	conjunctivitis	9.9	IL13 FOXP3
22	chronic inflammatory demyelinating polyradiculoneuropathy	9.9	TBX21 ALB
23	autoimmune disease of skin and connective tissue	9.9	IL13 FOXP3
24	blood protein disease	9.9	HBB ALB
25	type 1 diabetes mellitus 21	9.9	TBX21 GATA3 CD28
26	hypersplenism	9.9	FOXP3 ALB
27	bronchiolitis obliterans	9.8	IL13 FOXP3
28	cefaclor allergy	9.8	IL13 ALB
29	paracoccidioidomycosis	9.8	CD28 ALB
30	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.8	TBX21 FOXP3 CD28
31	syphilis	9.8	FOXP3 ALB
32	rectal disease	9.8	FOXP3 ALB
33	autoimmune pancreatitis	9.8	FOXP3 ALB
34	chronic meningitis	9.8	IL13 ALB
35	taeniasis	9.8	IL13 ALB
36	cardiomyopathy, familial hypertrophic, 20	9.8	IL13 ALB
37	fungal meningitis	9.8	IL13 ALB
38	drug allergy	9.8	IL13 ALB
39	sezary's disease	9.8	GATA3 FOXP3 CD28
40	drug-induced lupus erythematosus	9.8	IL13 ALB
41	conjunctival disease	9.8	IL13 ALB
42	splenic disease	9.8	IL13 ALB
43	hypersensitivity reaction type iv disease	9.8	FOXP3 ALB
44	lipoid nephrosis	9.8	IL13 ALB
45	filariasis	9.8	GATA3 ALB
46	lymph node disease	9.8	FOXP3 ALB
47	cutaneous leishmaniasis	9.8	IL13 FOXP3
48	cholelithiasis	9.8	HBB ALB
49	opportunistic mycosis	9.8	IL13 ALB
50	dermatitis, atopic	9.8	IL13 GATA3 FOXP3

Graphical network of the top 20 diseases related to Aneruptive Fever:

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Symptoms & Phenotypes for Aneruptive Fever

Symptoms:

¹²

• fever
• myalgia

• headache

MGI Mouse Phenotypes related to Aneruptive Fever:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.73	ALB CD28 FOXP3 GATA3 IL13 TBX21
2	digestive/alimentary	MP:0005381	9.63	ALB CD28 FOXP3 GATA3 IL13 TBX21
3	endocrine/exocrine gland	MP:0005379	9.43	ALB CD28 FOXP3 GATA3 IL13 TBX21
4	immune system	MP:0005387	9.1	ALB CD28 FOXP3 GATA3 IL13 TBX21

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Drugs & Therapeutics for Aneruptive Fever

Search Clinical Trials , NIH Clinical Center for Aneruptive Fever

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Genetic Tests for Aneruptive Fever

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Anatomical Context for Aneruptive Fever

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Publications for Aneruptive Fever

Articles related to Aneruptive Fever:

#	Title	Authors	PMID	Year
1	Rickettsia helvetica in Human-Parasitizing and Free-Living Ixodes ricinus from Urban and Wild Green Areas in the Metropolitan City of Rome, Italy. ⁶¹	Scarpulla M...Macri G	29664700	2018
2	Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. ⁶¹	Fournier PE...Raoult D	14766859	2004

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Genes for Aneruptive Fever

Genes related to Aneruptive Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HBB	Hemoglobin Subunit Beta	Protein Coding	4.33	DISEASES inferred ¹⁵
2	TBX21	T-Box Transcription Factor 21	Protein Coding	3.95	DISEASES inferred ¹⁵
3	GATA3	GATA Binding Protein 3	Protein Coding	3.85	DISEASES inferred ¹⁵
4	CD28	CD28 Molecule	Protein Coding	3.6	DISEASES inferred ¹⁵
5	IL13	Interleukin 13	Protein Coding	3.32	DISEASES inferred ¹⁵
6	ALB	Albumin	Protein Coding	3.28	DISEASES inferred ¹⁵
7	FOXP3	Forkhead Box P3	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Aneruptive Fever

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Expression for Aneruptive Fever

Search GEO for disease gene expression data for Aneruptive Fever.

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Pathways for Aneruptive Fever

Pathways related to Aneruptive Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.14	TBX21 GATA3 FOXP3 CD28
2	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	11.89	TBX21 IL13 GATA3 FOXP3 CD28
3	Glucocorticoid receptor regulatory network ¹	11.55	TBX21 IL13 GATA3
4	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.51	TBX21 IL13 GATA3
5	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.46	TBX21 GATA3 CD28
6	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.43	TBX21 GATA3 FOXP3
7	IgA-Producing B Cells in the Intestine ⁶⁴	11.3	FOXP3 CD28
8	Development and heterogeneity of the ILC family ¹	10.94	TBX21 IL13 GATA3
9	IL12 signaling mediated by STAT4 ¹	10.78	TBX21 IL13 CD28
10	Th2 Differentiation Pathway ⁶⁴	10.59	IL13 GATA3 FOXP3 CD28

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GO Terms for Aneruptive Fever

Biological processes related to Aneruptive Fever according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.71	GATA3 FOXP3 CD28
2	T cell receptor signaling pathway	GO:0050852	9.65	GATA3 FOXP3 CD28
3	negative regulation of inflammatory response	GO:0050728	9.61	IL13 GATA3 FOXP3
4	cellular response to cytokine stimulus	GO:0071345	9.58	IL13 GATA3
5	response to virus	GO:0009615	9.58	TBX21 GATA3 FOXP3
6	humoral immune response	GO:0006959	9.57	GATA3 CD28
7	T cell activation	GO:0042110	9.56	FOXP3 CD28
8	negative regulation of interferon-gamma production	GO:0032689	9.55	GATA3 FOXP3
9	positive regulation of gene expression	GO:0010628	9.55	TBX21 IL13 GATA3 FOXP3 CD28
10	T cell differentiation	GO:0030217	9.52	TBX21 GATA3
11	positive regulation of interleukin-10 production	GO:0032733	9.51	IL13 CD28
12	negative regulation of endothelial cell apoptotic process	GO:2000352	9.49	IL13 GATA3
13	regulation of regulatory T cell differentiation	GO:0045589	9.46	FOXP3 CD28
14	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.37	TBX21 FOXP3
15	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.32	TBX21 CD28
16	lymphocyte migration	GO:0072676	9.26	TBX21 GATA3
17	negative regulation of interleukin-2 production	GO:0032703	9.13	TBX21 GATA3 FOXP3
18	positive regulation of interleukin-4 production	GO:0032753	8.8	GATA3 FOXP3 CD28

Molecular functions related to Aneruptive Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:0043565	9.33	TBX21 GATA3 FOXP3
2	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO:0001227	9.13	TBX21 GATA3 FOXP3
3	oxygen binding	GO:0019825	8.62	HBB ALB

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Sources for Aneruptive Fever

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