MCID: ANR001
MIFTS: 24

Aneruptive Fever

Categories: Infectious diseases

Aliases & Classifications for Aneruptive Fever

MalaCards integrated aliases for Aneruptive Fever:

Name: Aneruptive Fever 12 15
Rickettsia Helvetica Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050484

Summaries for Aneruptive Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia helvetica, which is transmitted by ticks (Ixodes sp). The infection has symptom fever, has symptom headache, has symptom myalgia.

MalaCards based summary : Aneruptive Fever, also known as rickettsia helvetica spotted fever, is related to exanthem and headache, and has symptoms including fever, myalgia and headache. An important gene associated with Aneruptive Fever is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. Related phenotypes are cellular and digestive/alimentary

Related Diseases for Aneruptive Fever

Diseases related to Aneruptive Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 exanthem 10.3
2 headache 10.3
3 rare deficiency anemia 10.2 HBB FOXP3
4 macular degeneration, age-related, 8 10.1 TBX21 CD28
5 autoimmune disease of eyes, ear, nose and throat 10.1 TBX21 FOXP3
6 autoimmune disease of cardiovascular system 10.0 FOXP3 CD28
7 angioimmunoblastic t-cell lymphoma 10.0 TBX21 CD28
8 orange allergy 10.0 IL13 FOXP3
9 dacryoadenitis 10.0 IL13 FOXP3
10 nut allergy 9.9 IL13 FOXP3
11 paranasal sinus disease 9.9 IL13 GATA3
12 combined t cell and b cell immunodeficiency 9.9 FOXP3 CD28
13 pollen allergy 9.9 IL13 FOXP3
14 hemoglobin d disease 9.9 HBB ALB
15 kidney papillary necrosis 9.9 HBB ALB
16 milk allergy 9.9 IL13 FOXP3
17 allergic conjunctivitis 9.9 IL13 FOXP3
18 conjunctivitis 9.9 IL13 FOXP3
19 chronic inflammatory demyelinating polyradiculoneuropathy 9.9 TBX21 ALB
20 polyradiculoneuropathy 9.9 TBX21 ALB
21 blood protein disease 9.9 HBB ALB
22 bronchiolitis obliterans 9.8 IL13 FOXP3
23 parathyroid gland disease 9.8 GATA3 ALB
24 lymphoepithelioma-like thymic carcinoma 9.8 FOXP3 ALB
25 diabetes mellitus, insulin-dependent, 21 9.8 TBX21 GATA3 CD28
26 hypersplenism 9.8 FOXP3 ALB
27 autoimmune pancreatitis 9.8 FOXP3 ALB
28 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 TBX21 FOXP3 CD28
29 cefaclor allergy 9.7 IL13 ALB
30 cholelithiasis 9.7 HBB ALB
31 lymph node disease 9.7 FOXP3 ALB
32 cardiomyopathy, familial hypertrophic, 20 9.7 IL13 ALB
33 sezary's disease 9.7 GATA3 FOXP3 CD28
34 cutaneous leishmaniasis 9.7 IL13 FOXP3
35 splenic disease 9.7 IL13 ALB
36 neuromuscular junction disease 9.7 FOXP3 ALB
37 lipoid nephrosis 9.7 IL13 ALB
38 autoimmune disease of gastrointestinal tract 9.7 FOXP3 ALB
39 conjunctival disease 9.7 IL13 ALB
40 hypersensitivity reaction type iv disease 9.7 FOXP3 ALB
41 opportunistic mycosis 9.7 IL13 ALB
42 filariasis 9.7 GATA3 ALB
43 common cold 9.6 IL13 ALB
44 allergic hypersensitivity disease 9.6 IL13 GATA3 FOXP3
45 keratoconjunctivitis 9.6 IL13 ALB
46 dengue hemorrhagic fever 9.6 IL13 ALB
47 deficiency anemia 9.5 HBB FOXP3 ALB
48 immune deficiency disease 9.5 IL13 FOXP3 CD28
49 leprosy 3 9.5 FOXP3 ALB
50 bone inflammation disease 9.4 FOXP3 CD28 ALB

Graphical network of the top 20 diseases related to Aneruptive Fever:



Diseases related to Aneruptive Fever

Symptoms & Phenotypes for Aneruptive Fever

Symptoms:

12
  • fever
  • myalgia
  • headache

MGI Mouse Phenotypes related to Aneruptive Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 ALB CD28 FOXP3 GATA3 IL13 TBX21
2 digestive/alimentary MP:0005381 9.63 ALB CD28 FOXP3 GATA3 IL13 TBX21
3 endocrine/exocrine gland MP:0005379 9.43 ALB CD28 FOXP3 GATA3 IL13 TBX21
4 immune system MP:0005387 9.1 ALB CD28 FOXP3 GATA3 IL13 TBX21

Drugs & Therapeutics for Aneruptive Fever

Search Clinical Trials , NIH Clinical Center for Aneruptive Fever

Genetic Tests for Aneruptive Fever

Anatomical Context for Aneruptive Fever

Publications for Aneruptive Fever

Articles related to Aneruptive Fever:

# Title Authors PMID Year
1
Rickettsia helvetica in Human-Parasitizing and Free-Living Ixodes ricinus from Urban and Wild Green Areas in the Metropolitan City of Rome, Italy. 61
29664700 2018
2
Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. 61
14766859 2004

Variations for Aneruptive Fever

Expression for Aneruptive Fever

Search GEO for disease gene expression data for Aneruptive Fever.

Pathways for Aneruptive Fever

GO Terms for Aneruptive Fever

Biological processes related to Aneruptive Fever according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.87 TBX21 GATA3 FOXP3 CD28
2 negative regulation of gene expression GO:0010629 9.69 GATA3 FOXP3 CD28
3 T cell receptor signaling pathway GO:0050852 9.63 GATA3 FOXP3 CD28
4 cellular response to cytokine stimulus GO:0071345 9.56 IL13 GATA3
5 humoral immune response GO:0006959 9.55 GATA3 CD28
6 positive regulation of gene expression GO:0010628 9.55 TBX21 IL13 GATA3 FOXP3 CD28
7 T cell activation GO:0042110 9.54 FOXP3 CD28
8 response to virus GO:0009615 9.54 TBX21 GATA3 FOXP3
9 T cell differentiation GO:0030217 9.52 TBX21 GATA3
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 IL13 GATA3
11 negative regulation of interferon-gamma production GO:0032689 9.48 GATA3 FOXP3
12 regulation of regulatory T cell differentiation GO:0045589 9.43 FOXP3 CD28
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 TBX21 CD28
14 negative regulation of T-helper 17 cell differentiation GO:2000320 9.32 TBX21 FOXP3
15 lymphocyte migration GO:0072676 9.26 TBX21 GATA3
16 positive regulation of interleukin-4 production GO:0032753 9.13 GATA3 FOXP3 CD28
17 negative regulation of interleukin-2 production GO:0032703 8.8 TBX21 GATA3 FOXP3

Molecular functions related to Aneruptive Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.62 HBB ALB

Sources for Aneruptive Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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