MCID: ANR001
MIFTS: 24

Aneruptive Fever

Categories: Infectious diseases

Aliases & Classifications for Aneruptive Fever

MalaCards integrated aliases for Aneruptive Fever:

Name: Aneruptive Fever 12 15
Rickettsia Helvetica Spotted Fever 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050484

Summaries for Aneruptive Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia helvetica, which is transmitted by ticks (Ixodes sp). The infection has symptom fever, has symptom headache, has symptom myalgia.

MalaCards based summary : Aneruptive Fever, also known as rickettsia helvetica spotted fever, is related to immunodeficiency 27b and dermatitis, atopic, 5, and has symptoms including fever, myalgia and headache. An important gene associated with Aneruptive Fever is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are NF-kappaB Signaling and Th17 cell differentiation. Related phenotypes are cellular and digestive/alimentary

Related Diseases for Aneruptive Fever

Diseases related to Aneruptive Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 immunodeficiency 27b 10.1 TBX21 GATA3
2 dermatitis, atopic, 5 10.1 TBX21 GATA3
3 macular degeneration, age-related, 8 10.1 TBX21 CD28
4 dermatitis, atopic, 8 10.1 GATA3 FOXP3
5 autoimmune disease of eyes, ear, nose and throat 10.1 TBX21 FOXP3
6 exanthem 10.1
7 angioimmunoblastic t-cell lymphoma 10.0 TBX21 CD28
8 dacryoadenitis 10.0 IL13 FOXP3
9 egg allergy 10.0 IL13 FOXP3
10 filarial elephantiasis 10.0 IL13 FOXP3
11 legume allergy 10.0 IL13 FOXP3
12 fruit allergy 10.0 IL13 FOXP3
13 kidney papillary necrosis 10.0 HBB ALB
14 hemoglobin d disease 10.0 HBB ALB
15 splenic infarction 10.0 HBB ALB
16 paranasal sinus disease 10.0 IL13 GATA3
17 pollen allergy 10.0 IL13 FOXP3
18 milk allergy 9.9 IL13 FOXP3
19 glucosephosphate dehydrogenase deficiency 9.9 HBB ALB
20 allergic conjunctivitis 9.9 IL13 FOXP3
21 conjunctivitis 9.9 IL13 FOXP3
22 chronic inflammatory demyelinating polyradiculoneuropathy 9.9 TBX21 ALB
23 autoimmune disease of skin and connective tissue 9.9 IL13 FOXP3
24 blood protein disease 9.9 HBB ALB
25 type 1 diabetes mellitus 21 9.9 TBX21 GATA3 CD28
26 hypersplenism 9.9 FOXP3 ALB
27 bronchiolitis obliterans 9.8 IL13 FOXP3
28 cefaclor allergy 9.8 IL13 ALB
29 paracoccidioidomycosis 9.8 CD28 ALB
30 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 TBX21 FOXP3 CD28
31 syphilis 9.8 FOXP3 ALB
32 rectal disease 9.8 FOXP3 ALB
33 autoimmune pancreatitis 9.8 FOXP3 ALB
34 chronic meningitis 9.8 IL13 ALB
35 taeniasis 9.8 IL13 ALB
36 cardiomyopathy, familial hypertrophic, 20 9.8 IL13 ALB
37 fungal meningitis 9.8 IL13 ALB
38 drug allergy 9.8 IL13 ALB
39 sezary's disease 9.8 GATA3 FOXP3 CD28
40 drug-induced lupus erythematosus 9.8 IL13 ALB
41 conjunctival disease 9.8 IL13 ALB
42 splenic disease 9.8 IL13 ALB
43 hypersensitivity reaction type iv disease 9.8 FOXP3 ALB
44 lipoid nephrosis 9.8 IL13 ALB
45 filariasis 9.8 GATA3 ALB
46 lymph node disease 9.8 FOXP3 ALB
47 cutaneous leishmaniasis 9.8 IL13 FOXP3
48 cholelithiasis 9.8 HBB ALB
49 opportunistic mycosis 9.8 IL13 ALB
50 dermatitis, atopic 9.8 IL13 GATA3 FOXP3

Graphical network of the top 20 diseases related to Aneruptive Fever:



Diseases related to Aneruptive Fever

Symptoms & Phenotypes for Aneruptive Fever

Symptoms:

12
  • fever
  • myalgia
  • headache

MGI Mouse Phenotypes related to Aneruptive Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 ALB CD28 FOXP3 GATA3 IL13 TBX21
2 digestive/alimentary MP:0005381 9.63 ALB CD28 FOXP3 GATA3 IL13 TBX21
3 endocrine/exocrine gland MP:0005379 9.43 ALB CD28 FOXP3 GATA3 IL13 TBX21
4 immune system MP:0005387 9.1 ALB CD28 FOXP3 GATA3 IL13 TBX21

Drugs & Therapeutics for Aneruptive Fever

Search Clinical Trials , NIH Clinical Center for Aneruptive Fever

Genetic Tests for Aneruptive Fever

Anatomical Context for Aneruptive Fever

Publications for Aneruptive Fever

Articles related to Aneruptive Fever:

# Title Authors PMID Year
1
Rickettsia helvetica in Human-Parasitizing and Free-Living Ixodes ricinus from Urban and Wild Green Areas in the Metropolitan City of Rome, Italy. 61
29664700 2018
2
Aneruptive fever associated with antibodies to Rickettsia helvetica in Europe and Thailand. 61
14766859 2004

Variations for Aneruptive Fever

Expression for Aneruptive Fever

Search GEO for disease gene expression data for Aneruptive Fever.

Pathways for Aneruptive Fever

GO Terms for Aneruptive Fever

Biological processes related to Aneruptive Fever according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.71 GATA3 FOXP3 CD28
2 T cell receptor signaling pathway GO:0050852 9.65 GATA3 FOXP3 CD28
3 negative regulation of inflammatory response GO:0050728 9.61 IL13 GATA3 FOXP3
4 cellular response to cytokine stimulus GO:0071345 9.58 IL13 GATA3
5 response to virus GO:0009615 9.58 TBX21 GATA3 FOXP3
6 humoral immune response GO:0006959 9.57 GATA3 CD28
7 T cell activation GO:0042110 9.56 FOXP3 CD28
8 negative regulation of interferon-gamma production GO:0032689 9.55 GATA3 FOXP3
9 positive regulation of gene expression GO:0010628 9.55 TBX21 IL13 GATA3 FOXP3 CD28
10 T cell differentiation GO:0030217 9.52 TBX21 GATA3
11 positive regulation of interleukin-10 production GO:0032733 9.51 IL13 CD28
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 IL13 GATA3
13 regulation of regulatory T cell differentiation GO:0045589 9.46 FOXP3 CD28
14 negative regulation of T-helper 17 cell differentiation GO:2000320 9.37 TBX21 FOXP3
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 TBX21 CD28
16 lymphocyte migration GO:0072676 9.26 TBX21 GATA3
17 negative regulation of interleukin-2 production GO:0032703 9.13 TBX21 GATA3 FOXP3
18 positive regulation of interleukin-4 production GO:0032753 8.8 GATA3 FOXP3 CD28

Molecular functions related to Aneruptive Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.33 TBX21 GATA3 FOXP3
2 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 9.13 TBX21 GATA3 FOXP3
3 oxygen binding GO:0019825 8.62 HBB ALB

Sources for Aneruptive Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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