MCID: ANR040
MIFTS: 60

Aneurysm

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Aneurysm

MalaCards integrated aliases for Aneurysm:

Name: Aneurysm 54 55 63 17 72
Aneurysms 43

Classifications:



External Ids:

UMLS 72 C0002940

Summaries for Aneurysm

NINDS : 54 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Aneurysm, also known as aneurysms, is related to aortic aneurysm, familial thoracic 6 and familial thoracic aortic aneurysm and dissection, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aneurysm is TGFBR2 (Transforming Growth Factor Beta Receptor 2), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Everolimus and Telmisartan have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are Decreased viability and Decreased viability

MedlinePlus : 43 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms occur in the aorta, the main artery that runs from the heart through the chest and abdomen. Aneurysms also can happen in arteries in the brain, heart and other parts of the body. If an aneurysm in the brain bursts, it causes a stroke. Aneurysms can develop and become large before causing any symptoms. Often doctors can stop aneurysms from bursting if they find and treat them early. They use imaging tests to find aneurysms. Often aneurysms are found by chance during tests done for other reasons. Medicines and surgery are the two main treatments for aneurysms. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 63 About aneurysm: An aneurysm (AN-u-rism) is a balloon-like bulge in an artery. Arteries are blood vessels that carry oxygen-rich blood to your body. Arteries have thick walls to withstand normal blood pressure. However, certain medical problems, genetic conditions, and trauma can damage or injure artery walls. The force of blood pushing against the weakened or injured walls can cause an aneurysm. An aneurysm can grow large and rupture (burst) or dissect. A rupture causes dangerous bleeding inside the body. A dissection is a split in one or more layers of the artery wall. The split causes bleeding into and along the layers of the artery wall. Both rupture and dissection often are fatal.

Wikipedia : 75 An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak... more...

Related Diseases for Aneurysm

Diseases related to Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2050)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial thoracic 6 34.5 MYLK MYH11 ACTA2
2 familial thoracic aortic aneurysm and dissection 34.3 TGFBR2 TGFBR1 SMAD3 FBN1 COL3A1
3 intracranial aneurysm 34.0 LOX FBN2 ELN COL3A1
4 aortic aneurysm, familial thoracic 2 34.0 SLC2A10 FBN1 ACTA2
5 subclavian artery aneurysm 33.8 TGFBR2 MYH11
6 familial abdominal aortic aneurysm 33.7 MYLK FBN1 ELN COL3A1
7 loeys-dietz syndrome 4 33.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
8 arterial tortuosity syndrome 33.0 TGFBR1 SLC2A10 ELN
9 aortic aneurysm, familial thoracic 1 32.9 TGFBR2 TGFBR1 SMAD3 SLC2A10 MYH11 FBN1
10 loeys-dietz syndrome 1 32.9 TGFBR2 TGFBR1 TGFB2 SMAD3 MYH11 FBN1
11 cutis laxa, autosomal recessive, type ib 32.6 LOX ELN
12 autosomal recessive cutis laxa type i 32.6 TGFBR2 TGFBR1 LOX ELN
13 aortic valve insufficiency 31.6 NOTCH1 FBN1 ELN
14 marfan syndrome 31.6 TGFBR2 TGFBR1 FBN2 FBN1 ELN COL3A1
15 loeys-dietz syndrome 3 31.5 TGFBR2 TGFBR1 TGFB2 SMAD3 PRKG1 MYLK
16 loeys-dietz syndrome 31.3 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MYLK
17 ehlers-danlos syndrome, vascular type 30.6 ELN COL3A1
18 mitral valve disease 30.5 TGFB3 TGFB2 FBN1
19 aortic valve disease 1 30.3 TGFBR2 NOTCH1 FBN2 FBN1 ELN ACTA2
20 tricuspid valve prolapse 30.3 SMAD3 FBN1
21 connective tissue disease 30.3 FBN2 FBN1 ELN COL3A1 ACTA2
22 char syndrome 29.9 TGFBR2 FBN1 COL3A1 ACTA2
23 exfoliation syndrome 29.8 LOX FBN1 ELN
24 aortic disease 29.7 TGFBR2 TGFBR1 TGFB2 PRKG1 NOTCH1 MYH11
25 pelvic organ prolapse 29.6 MYH11 ELN COL3A1
26 aortic aneurysm 28.9 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 PRKG1
27 aortic aneurysm, familial abdominal, 1 12.9
28 aneurysmal bone cysts 12.7
29 cerebral aneurysms 12.7
30 heart aneurysm 12.7
31 angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 12.7
32 coronary artery aneurysm 12.6
33 intracranial berry aneurysm 12.6
34 aneurysm of sinus of valsalva 12.6
35 aortic aneurysm, familial thoracic 4 12.6
36 aortic aneurysm, familial thoracic 10 12.5
37 aortic aneurysm, familial thoracic 11 12.5
38 aortic aneurysm, familial thoracic 9 12.5
39 aneurysm, intracranial berry, 2 12.5
40 vein of galen aneurysm 12.5
41 aortic aneurysm, familial thoracic 8 12.5
42 aneurysm, intracranial berry, 3 12.5
43 aneurysm, intracranial berry, 6 12.5
44 aneurysm, intracranial berry, 5 12.5
45 aneurysm, intracranial berry, 9 12.5
46 aneurysm, intracranial berry, 7 12.5
47 aneurysm, intracranial berry, 8 12.5
48 aneurysm, intracranial berry, 10 12.5
49 aneurysm, intracranial berry, 4 12.5
50 aneurysm, intracranial berry, 11 12.5

Graphical network of the top 20 diseases related to Aneurysm:



Diseases related to Aneurysm

Symptoms & Phenotypes for Aneurysm

UMLS symptoms related to Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00301-A 9.92 PRKG1
7 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aneurysm:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACTA2 COL3A1 FBN1 FBN2 LOX MFAP5
2 homeostasis/metabolism MP:0005376 10.31 BGN COL3A1 FBN1 FBN2 LOX MMP12
3 cellular MP:0005384 10.3 BGN COL3A1 FBN1 FBN2 MYH11 NOTCH1
4 growth/size/body region MP:0005378 10.26 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5 immune system MP:0005387 10.25 BGN COL3A1 FBN1 MFAP5 MMP12 MYLK
6 hematopoietic system MP:0005397 10.2 FBN1 MFAP5 MMP12 NOTCH1 PRKG1 SLC2A10
7 digestive/alimentary MP:0005381 10.19 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 mortality/aging MP:0010768 10.17 BGN COL3A1 FBN1 FBN2 LOX MYH11
9 craniofacial MP:0005382 10.11 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 muscle MP:0005369 10.07 ACTA2 BGN COL3A1 FBN1 FBN2 LOX
11 integument MP:0010771 10.02 BGN COL3A1 FBN1 LOX MMP12 MYH11
12 renal/urinary system MP:0005367 9.76 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
13 respiratory system MP:0005388 9.73 COL3A1 FBN1 FBN2 LOX MMP12 MYH11
14 skeleton MP:0005390 9.36 BGN FBN1 FBN2 MFAP5 MYLK NOTCH1

Drugs & Therapeutics for Aneurysm

PubMed Health treatment related to Aneurysm: 63

Aortic aneurysms are treated with medicines and surgery. Small aneurysms that are found early and aren’t causing symptoms may not need treatment. Other aneurysms need to be treated. The goals of treatment may include: Preventing the aneurysm from growingPreventing or reversing damage to other body structuresPreventing or treating a rupture or dissectionAllowing you to continue doing your normal daily activities Treatment for an aortic aneurysm is based on its size. Your doctor may recommend routine testing to make sure an aneurysm isn't getting bigger. This method usually is used for aneurysms that are smaller than 5 centimeters (about 2 inches) across. How often you need testing (for example, every few months or every year) is based on the size of the aneurysm and how fast it's growing. The larger it is and the faster it's growing, the more often you may need to be checked.

Drugs for Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 419)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
2
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Atorvastatin Approved Phase 4 134523-00-5 60823
5
Iodine Approved, Investigational Phase 4 7553-56-2 807
6
Remifentanil Approved Phase 4 132875-61-7 60815
7
Atenolol Approved Phase 4 29122-68-7 2249
8
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
9
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
10
Enalaprilat Approved Phase 4 76420-72-9 6917719
11
Enoxaparin Approved Phase 4 9005-49-6 772
12
Ticagrelor Approved Phase 4 274693-27-5 9871419
13
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
14
Eplerenone Approved Phase 4 107724-20-9 150310 443872
15
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
16
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
17
Desflurane Approved Phase 4 57041-67-5 42113
18
Phylloquinone Approved, Investigational Phase 4 84-80-0
19
Ramipril Approved Phase 4 87333-19-5 5362129
20
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
21
Glyburide Approved Phase 4 10238-21-8 3488
22
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 23925 27284
23
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
24
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
25
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
26
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
27
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
28
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
29
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
30
Clevidipine Approved, Investigational Phase 4 167221-71-8
31
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
32
Tenecteplase Approved Phase 4 191588-94-0
33
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
34
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
35
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
36 Menaquinone Investigational Phase 4 1182-68-9
37 Antibodies Phase 4
38 Immunologic Factors Phase 4
39 Immunoglobulins Phase 4
40 Protective Agents Phase 4
41 Antifungal Agents Phase 4
42 HIV Protease Inhibitors Phase 4
43
protease inhibitors Phase 4
44 Vasodilator Agents Phase 4
45 calcium channel blockers Phase 4
46 Tryptophan Phase 4
47 cadexomer iodine Phase 4
48 Adrenergic beta-1 Receptor Antagonists Phase 4
49 Adrenergic beta-Antagonists Phase 4
50 Adrenergic Antagonists Phase 4

Interventional clinical trials:

(show top 50) (show all 1381)
# Name Status NCT ID Phase Drugs
1 Comparative Study of Covered Stent With Coil Embolization in the Treatment of Cranial Internal Carotid Artery Aneurysm: A Nonrandomized Prospective Trial Unknown status NCT01029938 Phase 4
2 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
3 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
4 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
5 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
6 Multicenter Clinical Study Assessing the Performance and the Safety of the Second Generation Antimicrobial Graft in the Abdominal Position Unknown status NCT00824109 Phase 4
7 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Unknown status NCT02478346 Phase 4 Fluorescein Sodium
8 Evaluation of Closed Incision Negative Pressure Device (Prevena) to Prevent Vascular Wound Complications Unknown status NCT02581904 Phase 4
9 A Prospective Randomized Multicenter Study of the Efficacy and Safety of Systematic Post -Dilatation With Noncompliant Balloon After Successful Drug-eluting Stent Implantation. IVUS Analysis. Unknown status NCT01103765 Phase 4
10 A Randomised Controlled Trial of the Effectiveness of Ultrasound Guidance in Cannulation of Dialysis Arteriovenous Fistulas and Grafts in a University Hospital Dialysis Unit Unknown status NCT01163981 Phase 4
11 Comparison of the Efficacy of Everolimus-Eluting Versus Sirolimus-Eluting Stent for Coronary Lesions Unknown status NCT00698607 Phase 4 6-month clopidogrel therapy;12-month clopidogrel therapy
12 Randomised Clinical Trial to Evaluate the Obtention of Blood Samples Through an Arterial Catheter to Monitor Glycose Levels Unknown status NCT01176279 Phase 4
13 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
14 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
15 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
16 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
17 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
18 A Prospective, Randomized, Multicenter Trial Investigating Matrix 2® and GDC® Detachable Coils for the Treatment of Intracranial Saccular Aneurysms Completed NCT00396981 Phase 4
19 ACE: An Aneurysm Coiling Efficiency Study of the Penumbra Coil 400 System Completed NCT01465841 Phase 4
20 Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry Completed NCT01444664 Phase 4
21 PRET: Patients Prone to Recurrence After Endovascular Treatment. A Randomized Trial Comparing Platinum and Hydrogel-coated Coils Completed NCT00626912 Phase 4
22 Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
23 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
24 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
25 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
26 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
27 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
28 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
29 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
30 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
31 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
32 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
33 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
34 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery. Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
35 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
36 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
37 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
38 Identification and Quantification of the Effects of a Surgery-induced Peripheral Inflammatory Response on Changes in Drug Efflux Transporter Function in the Brain Completed NCT00878371 Phase 4 morphine
39 The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Concentration During General Anesthesia Induction Completed NCT02135016 Phase 4 1% lidocaine;2% lidocaine;0.9% normal saline
40 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed NCT01452256 Phase 4 Desflurane;Propofol
41 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
42 Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management Completed NCT01725607 Phase 4 general anesthesia combined with dexmedetomidine infusion
43 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
44 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
45 Comparison of Stent Graft, Sirolimus Stent, and Bare Metal Stent Implanted in Patients With Acute Coronary Syndrome: Clinical and Angiographic Follow-up Completed NCT00452517 Phase 4
46 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)
47 Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study (EVAS): Effect of Eicosapentaenoic Acid on Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT00839449 Phase 4 Eicosapentaenoic acid ethyl ester
48 The Safety and Efficacy of an Extravascular, Water-Soluble Sealant for Venous Access-Site Closure Completed NCT02438475 Phase 4
49 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Completed NCT02097017 Phase 4 Lidocaine
50 Comparison Of Pharmacological Neuroprotection Provided By PROPOFOL VERSUS DESFLURANE For Long Term Postoperative Cognitive Dysfunction In Patients Undergoing Surgery For Aneurysmal Subarachnoid Hemorrhage Completed NCT02987218 Phase 4 Propofol;Desflurane

Search NIH Clinical Center for Aneurysm

Genetic Tests for Aneurysm

Anatomical Context for Aneurysm

MalaCards organs/tissues related to Aneurysm:

41
Brain, Heart, Kidney, Lung, Testes, Spinal Cord, Endothelial

Publications for Aneurysm

Articles related to Aneurysm:

(show top 50) (show all 57697)
# Title Authors PMID Year
1
Brief review: Pulmonary artery aneurysms and pseudoaneurysms. 38 17
31190207 2019
2
Renal Arterial Pseudoaneurysm After Partial Nephrectomy: Literature Review and Single-Center Analysis of Predictive Factors and Renal Functional Outcomes. 17
30300074 2019
3
Pseudoaneurysm. 17
30261523 2018
4
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. 9 38
20487632 2010
5
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation. 9 38
20173550 2010
6
MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans. 9 38
20177108 2010
7
Cathepsin K gene disruption does not affect murine aneurysm formation. 9 38
19775691 2010
8
Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. 9 38
20212283 2010
9
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. 9 38
20019329 2010
10
Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B. 9 38
20101701 2010
11
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. 9 38
20101093 2010
12
Elastase-induced intracranial aneurysms in hypertensive mice. 9 38
19884566 2009
13
Smooth muscle phenotypic modulation is an early event in aortic aneurysms. 9 38
19931668 2009
14
Aneurysm formation and bradykinin. 9 38
19707733 2009
15
Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. 9 38
19542084 2009
16
Elastin gene study of infants with isolated congenital ductus arteriosus aneurysm. 9 38
19593948 2009
17
Modelling the growth and stabilization of cerebral aneurysms. 9 38
19234094 2009
18
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. 9 38
19304942 2009
19
Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair. 9 38
20103998 2009
20
Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm. 9 38
18931513 2009
21
Elastin degradation within the abdominal aortic aneurysm wall--relationship between intramural pH and adjacent thrombus formation. 9 38
19021711 2008
22
Ruptured giant aneurysm of the left anterior descending coronary artery in Kawasaki disease. 9 38
18535756 2008
23
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. 9 38
18635848 2008
24
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair. 9 38
19238864 2008
25
Thoracic aortic aneurysm: reading the enemy's playbook. 9 38
18439439 2008
26
A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. 9 38
18389341 2008
27
Bilateral cavernous internal carotid aneurysms in a child with juvenile paget disease and osteoprotegerin deficiency. 9 38
17947367 2008
28
Cysteine protease activity in the wall of abdominal aortic aneurysms. 9 38
18155003 2007
29
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms. 9 38
17875574 2007
30
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. 9 38
17885220 2007
31
Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. 9 38
17721627 2007
32
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays. 9 38
17494658 2007
33
Severe aortic and arterial aneurysms associated with a TGFBR2 mutation. 9 38
17330129 2007
34
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair. 9 38
17277243 2007
35
Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm. 9 38
17714769 2007
36
Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms. 9 38
17198804 2007
37
Genes predisposing to rapid aneurysm growth. 9 38
17182940 2006
38
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. 9 38
17182923 2006
39
Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis. 9 38
17182933 2006
40
Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms. 9 38
16987162 2006
41
The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. 9 38
16961137 2006
42
Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. 9 38
16776339 2006
43
The elevated level of circulating matrix metalloproteinase-9 in patients with abdominal aortic aneurysms decreased to levels equal to those of healthy controls after an aortic repair. 9 38
16779512 2006
44
A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2. 9 38
16476613 2006
45
Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall. 9 38
16136262 2005
46
Genetic basis of thoracic aortic aneurysms and aortic dissections. 9 38
16273536 2005
47
Association of osteoprotegerin with human abdominal aortic aneurysm progression. 9 38
15939823 2005
48
Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. 9 38
15652949 2005
49
Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. 9 38
15561045 2004
50
Rapamycin suppresses experimental aortic aneurysm growth. 9 38
15297830 2004

Variations for Aneurysm

Expression for Aneurysm

Search GEO for disease gene expression data for Aneurysm.

Pathways for Aneurysm

Pathways related to Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
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13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
3
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13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
4
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13.08 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 ELN
5
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13.05 TGFBR2 TGFBR1 SMAD3 PRKG1 COL3A1 ACTA2
6
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12.96 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
7
Show member pathways
12.89 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
8 12.87 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
9
Show member pathways
12.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
10
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12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
12
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12.51 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
13 12.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
14
Show member pathways
12.31 TGFB3 TGFB2 MMP12 MFAP5 LOX FBN2
15 12.29 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
16
Show member pathways
12.24 TGFBR2 TGFBR1 TGFB2 SMAD3
17 12.22 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
18
Show member pathways
12.2 MYLK MYH11 MMP12 FBN2 FBN1 ELN
19 12.19 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20
Show member pathways
12.13 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
21 12.12 TGFBR1 SMAD3 MYLK ACTA2
22
Show member pathways
12.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23 12.1 TGFBR2 TGFBR1 SMAD3 MMP12
24 12.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MMP12
25
Show member pathways
12.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
26 11.99 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
27 11.9 TGFB3 TGFB2 COL3A1
28 11.9 TGFBR1 TGFB3 TGFB2 NOTCH1
29 11.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
30 11.88 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
31
Show member pathways
11.85 TGFBR2 TGFBR1 SMAD3
32 11.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
33
Show member pathways
11.83 TGFBR2 TGFBR1 SMAD3 LOX
34 11.74 TGFBR2 TGFBR1 SMAD3
35 11.73 TGFBR2 TGFBR1 SMAD3
36
Show member pathways
11.72 TGFBR2 TGFBR1 SMAD3
37 11.67 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
38
Show member pathways
11.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
39 11.63 TGFBR2 TGFBR1 SMAD3
40 11.62 TGFB3 TGFB2 BGN
41 11.61 TGFBR2 TGFBR1 TGFB3 SMAD3
42 11.55 TGFBR2 TGFBR1 TGFB2
43 11.52 TGFBR2 TGFBR1 TGFB3 TGFB2
44 11.42 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
45 11.4 MYLK MYH11 ACTA2
46
Show member pathways
11.27 TGFBR2 TGFBR1 TGFB3
47 11.25 TGFBR2 TGFBR1 TGFB3
48 11.14 TGFBR2 TGFBR1 SMAD3
49 11.13 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
50 11.06 TGFB3 TGFB2 MYLK FBN2 FBN1 ELN

GO Terms for Aneurysm

Cellular components related to Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.77 TGFBR2 TGFBR1 TGFB3 NOTCH1 BGN
2 receptor complex GO:0043235 9.62 TGFBR2 TGFBR1 SMAD3 NOTCH1
3 extracellular matrix GO:0031012 9.56 MMP12 MFAP5 LOX FBN2 FBN1 ELN
4 microfibril GO:0001527 9.33 MFAP5 FBN2 FBN1
5 collagen-containing extracellular matrix GO:0062023 9.23 TGFB3 TGFB2 MFAP5 FBN2 FBN1 ELN
6 extracellular region GO:0005576 10 TGFB3 TGFB2 NOTCH1 MMP12 MFAP5 LOX

Biological processes related to Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.97 TGFBR2 TGFB3 TGFB2 NOTCH1
2 in utero embryonic development GO:0001701 9.97 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
3 cell cycle arrest GO:0007050 9.93 TGFBR1 TGFB2 SMAD3 NOTCH1
4 kidney development GO:0001822 9.91 TGFBR1 TGFB2 FBN1
5 muscle contraction GO:0006936 9.91 MYLK MYH11 ACTA2
6 lung development GO:0030324 9.9 TGFBR2 NOTCH1 LOX
7 camera-type eye development GO:0043010 9.87 FOXE3 FBN2 FBN1
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.86 TGFBR1 SMAD3 FBN1
9 heart looping GO:0001947 9.86 TGFBR2 SMAD3 NOTCH1
10 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.86 TGFBR2 TGFBR1 TGFB3 SMAD3
11 cell development GO:0048468 9.85 TGFB3 TGFB2 FOXE3
12 SMAD protein signal transduction GO:0060395 9.85 TGFB3 TGFB2 SMAD3
13 embryonic limb morphogenesis GO:0030326 9.85 TGFB2 NOTCH1 FBN2
14 outflow tract morphogenesis GO:0003151 9.85 TGFBR2 NOTCH1 ELN
15 skeletal system development GO:0001501 9.85 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
16 extracellular matrix organization GO:0030198 9.85 MFAP5 FBN2 FBN1 ELN COL3A1 BGN
17 positive regulation of stress fiber assembly GO:0051496 9.84 TGFBR1 TGFB3 SMAD3
18 response to hypoxia GO:0001666 9.84 TGFBR2 TGFB3 TGFB2 SMAD3
19 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.83 TGFBR1 TGFB3 TGFB2
20 lens development in camera-type eye GO:0002088 9.8 TGFBR2 TGFBR1 FOXE3
21 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
22 epithelial to mesenchymal transition GO:0001837 9.79 TGFBR1 TGFB2 NOTCH1
23 embryonic cranial skeleton morphogenesis GO:0048701 9.79 TGFBR2 TGFBR1 SMAD3
24 positive regulation of bone mineralization GO:0030501 9.77 TGFB3 SMAD3 FBN2
25 digestive tract development GO:0048565 9.77 TGFBR2 TGFB3 COL3A1
26 cell-cell junction organization GO:0045216 9.75 TGFB3 TGFB2 SMAD3
27 smooth muscle contraction GO:0006939 9.73 MYLK MYH11
28 endocardial cushion morphogenesis GO:0003203 9.73 TGFB2 NOTCH1
29 activin receptor signaling pathway GO:0032924 9.73 TGFBR1 SMAD3
30 regulation of epithelial cell proliferation GO:0050678 9.73 SMAD3 NOTCH1
31 collagen fibril organization GO:0030199 9.73 TGFBR1 TGFB2 LOX COL3A1
32 pulmonary valve morphogenesis GO:0003184 9.72 TGFB2 NOTCH1
33 negative regulation of immune response GO:0050777 9.72 TGFB2 COL3A1
34 cardiac muscle cell proliferation GO:0060038 9.72 TGFB2 NOTCH1
35 supramolecular fiber organization GO:0097435 9.72 MFAP5 COL3A1
36 positive regulation of SMAD protein signal transduction GO:0060391 9.72 TGFBR1 TGFB3
37 ventricular trabecula myocardium morphogenesis GO:0003222 9.72 TGFBR1 TGFB2 NOTCH1
38 somatic stem cell division GO:0048103 9.71 TGFB2 NOTCH1
39 salivary gland morphogenesis GO:0007435 9.71 TGFB3 TGFB2
40 response to cholesterol GO:0070723 9.71 TGFBR2 TGFBR1
41 membranous septum morphogenesis GO:0003149 9.71 TGFBR2 TGFB2
42 ventricular septum morphogenesis GO:0060412 9.71 TGFBR2 TGFBR1 TGFB2 NOTCH1
43 cardiac left ventricle morphogenesis GO:0003214 9.7 TGFBR2 NOTCH1
44 embryonic eye morphogenesis GO:0048048 9.7 FBN2 FBN1
45 elastic fiber assembly GO:0048251 9.7 MYH11 LOX
46 coronary artery morphogenesis GO:0060982 9.7 TGFBR1 NOTCH1
47 secondary palate development GO:0062009 9.7 TGFBR2 TGFB3 TGFB2
48 pathway-restricted SMAD protein phosphorylation GO:0060389 9.69 TGFBR2 TGFBR1 TGFB2
49 cardiac epithelial to mesenchymal transition GO:0060317 9.67 TGFBR1 TGFB2 NOTCH1
50 negative regulation of macrophage cytokine production GO:0010936 9.65 TGFB3 TGFB2

Molecular functions related to Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.58 TGFB3 TGFB2 SMAD3
2 SMAD binding GO:0046332 9.56 TGFBR2 TGFBR1 SMAD3 COL3A1
3 transforming growth factor beta binding GO:0050431 9.5 TGFBR2 TGFBR1 TGFB3
4 transforming growth factor beta-activated receptor activity GO:0005024 9.48 TGFBR2 TGFBR1
5 type I transforming growth factor beta receptor binding GO:0034713 9.46 TGFBR2 TGFB3
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.43 TGFBR2 TGFBR1
7 type III transforming growth factor beta receptor binding GO:0034714 9.37 TGFB3 TGFB2
8 type II transforming growth factor beta receptor binding GO:0005114 9.33 TGFBR1 TGFB3 TGFB2
9 extracellular matrix constituent conferring elasticity GO:0030023 9.13 FBN2 FBN1 ELN
10 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN2 FBN1 ELN COL3A1 BGN

Sources for Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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