MCID: ANR040
MIFTS: 58

Aneurysm

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Aneurysm

MalaCards integrated aliases for Aneurysm:

Name: Aneurysm 53 54 62 17 71
Aneurysms 42

Classifications:



External Ids:

UMLS 71 C0002940

Summaries for Aneurysm

NINDS : 53 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Aneurysm, also known as aneurysms, is related to aortic aneurysm, familial abdominal, 1 and subclavian artery aneurysm, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Aneurysm is TGFBR2 (Transforming Growth Factor Beta Receptor 2), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Everolimus and Eplerenone have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and kidney, and related phenotypes are Decreased viability and Decreased viability

MedlinePlus : 42 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms occur in the aorta, the main artery that runs from the heart through the chest and abdomen. Aneurysms also can happen in arteries in the brain, heart and other parts of the body. If an aneurysm in the brain bursts, it causes a stroke. Aneurysms can develop and become large before causing any symptoms. Often doctors can stop aneurysms from bursting if they find and treat them early. They use imaging tests to find aneurysms. Often aneurysms are found by chance during tests done for other reasons. Medicines and surgery are the two main treatments for aneurysms. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 62 About aneurysm: An aneurysm (AN-u-rism) is a balloon-like bulge in an artery. Arteries are blood vessels that carry oxygen-rich blood to your body. Arteries have thick walls to withstand normal blood pressure. However, certain medical problems, genetic conditions, and trauma can damage or injure artery walls. The force of blood pushing against the weakened or injured walls can cause an aneurysm. An aneurysm can grow large and rupture (burst) or dissect. A rupture causes dangerous bleeding inside the body. A dissection is a split in one or more layers of the artery wall. The split causes bleeding into and along the layers of the artery wall. Both rupture and dissection often are fatal.

Wikipedia : 74 An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak... more...

Related Diseases for Aneurysm

Diseases related to Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2055)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 34.4 MMP12 FBN1 ELN
2 subclavian artery aneurysm 34.1 TGFBR2 FBN1
3 aortic aneurysm, familial thoracic 6 33.7 TGFBR1 SLC2A10 MYLK MYH11 ACTA2
4 familial abdominal aortic aneurysm 33.6 MYLK FBN1 ELN COL3A1
5 intracranial aneurysm 33.2 TGFBR2 TGFBR1 TGFB2 LOX FBN2 ELN
6 aortic aneurysm, familial thoracic 2 33.1 SLC2A10 FBN2 FBN1 COL3A1 ACTA2
7 autosomal recessive cutis laxa type i 32.6 SLC2A10 FBN1 ELN
8 loeys-dietz syndrome 4 32.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
9 loeys-dietz syndrome 3 32.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
10 moyamoya disease 1 32.1 TGFBR2 MYLK MYH11 ELN ACTA2
11 cutis laxa, autosomal dominant 1 32.0 TGFBR2 TGFBR1 SLC2A10 FBN1 ELN
12 loeys-dietz syndrome 5 31.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
13 loeys-dietz syndrome 1 31.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
14 arterial tortuosity syndrome 31.3 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYH11
15 patent ductus arteriosus 1 31.0 TGFBR2 TGFBR1 SLC2A10 NOTCH1 MYLK MYH11
16 aortic valve insufficiency 31.0 TGFBR2 TGFBR1 MYH11 FBN1 ELN ACTA2
17 telangiectasis 30.8 TGFBR1 FBN1 ELN
18 varicose veins 30.8 FBN1 ELN COL3A1
19 inguinal hernia 30.6 LOX FBN1 ELN
20 atrial heart septal defect 30.6 NOTCH1 FBN1 ELN
21 pulsating exophthalmos 30.5 TGFBR2 TGFBR1 COL3A1
22 hereditary hemorrhagic telangiectasia 30.5 TGFBR2 TGFBR1 TGFB2
23 aortic valve disease 2 30.5 NOTCH1 FBN1 ELN
24 ehlers-danlos syndrome, vascular type 30.5 ELN COL3A1
25 ehlers-danlos syndrome 30.4 TGFBR1 SLC2A10 MYH11 FBN1 ELN COL3A1
26 heart valve disease 30.4 NOTCH1 FBN1 ELN
27 pseudoxanthoma elasticum 30.3 MYH11 FBN1 ELN
28 cutis laxa 30.3 LOX FBN1 ELN
29 mitral valve disease 30.1 TGFB3 TGFB2 FBN1 ELN
30 brittle bone disorder 30.0 FBN1 ELN COL3A1 BGN
31 collagen disease 30.0 TGFBR1 SMAD3 FBN1 ELN COL3A1
32 loeys-dietz syndrome 29.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
33 pulmonary emphysema 29.8 MMP12 LOX ELN
34 marfan syndrome 29.8 TGFBR2 TGFBR1 TGFB2 NOTCH1 MYLK MYH11
35 eisenmenger syndrome 29.8 TGFBR2 TGFBR1
36 exfoliation syndrome 29.7 LOX FBN1 ELN
37 connective tissue disease 29.6 TGFBR2 SMAD3 LOX FBN2 FBN1 ELN
38 glaucoma, primary open angle 29.6 TGFB2 FBN1 ELN
39 familial thoracic aortic aneurysm and dissection 29.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
40 tricuspid valve prolapse 29.5 TGFBR2 TGFBR1 SLC2A10 FBN1 COL3A1
41 aortic aneurysm, familial thoracic 1 29.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
42 scoliosis 29.5 TGFBR2 TGFB2 LOX FBN2 FBN1 ELN
43 cerebral arterial disease 29.4 ELN COL3A1 ACTA2
44 pelvic organ prolapse 29.4 LOX ELN COL3A1
45 bladder diverticulum 29.4 SLC2A10 LOX ELN
46 diaphragmatic hernia, congenital 29.3 SLC2A10 FBN1 ELN
47 aortic aneurysm 28.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
48 orthostatic intolerance 28.8 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 FBN2
49 pulmonary fibrosis, idiopathic 28.4 TGFBR1 SMAD3 MMP12 LOX ELN COL3A1
50 aortic valve disease 1 27.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10

Graphical network of the top 20 diseases related to Aneurysm:



Diseases related to Aneurysm

Symptoms & Phenotypes for Aneurysm

UMLS symptoms related to Aneurysm:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 9.92 TGFBR2
2 Decreased viability GR00221-A-1 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 9.92 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 9.92 TGFBR2
5 Decreased viability GR00221-A-4 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00301-A 9.92 PRKG1
7 Decreased viability GR00402-S-2 9.92 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aneurysm:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACTA2 COL3A1 FBN1 FBN2 LOX MFAP5
2 homeostasis/metabolism MP:0005376 10.31 BGN COL3A1 FBN1 FBN2 LOX MMP12
3 cellular MP:0005384 10.3 BGN COL3A1 FBN1 FBN2 MYH11 NOTCH1
4 growth/size/body region MP:0005378 10.26 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
5 immune system MP:0005387 10.25 BGN COL3A1 FBN1 MFAP5 MMP12 MYLK
6 hematopoietic system MP:0005397 10.23 COL3A1 FBN1 MFAP5 MMP12 NOTCH1 PRKG1
7 digestive/alimentary MP:0005381 10.19 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 mortality/aging MP:0010768 10.17 BGN COL3A1 FBN1 FBN2 LOX MYH11
9 craniofacial MP:0005382 10.11 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 integument MP:0010771 10.07 BGN COL3A1 FBN1 LOX MMP12 MYH11
11 muscle MP:0005369 10.07 ACTA2 BGN COL3A1 FBN1 FBN2 LOX
12 renal/urinary system MP:0005367 9.81 FBN1 MYH11 MYLK NOTCH1 PRKG1 SLC2A10
13 respiratory system MP:0005388 9.73 COL3A1 FBN1 FBN2 LOX MMP12 MYH11
14 skeleton MP:0005390 9.4 BGN FBN1 FBN2 LOX MFAP5 MYLK

Drugs & Therapeutics for Aneurysm

PubMed Health treatment related to Aneurysm: 62

Aortic aneurysms are treated with medicines and surgery . Small aneurysms that are found early and aren’t causing symptoms may not need treatment . Other aneurysms need to be treated. The goals of treatment may include: Preventing the aneurysm from growing Preventing or reversing damage to other body structures Preventing or treating a rupture or dissection Allowing you to continue doing your normal daily activities Treatment for an aortic aneurysm is based on its size. Your doctor may recommend routine testing to make sure an aneurysm isn't getting bigger. This method usually is used for aneurysms that are smaller than 5 centimeters (about 2 inches) across. How often you need testing (for example, every few months or every year) is based on the size of the aneurysm and how fast it's growing. The larger it is and the faster it's growing, the more often you may need to be checked.

Drugs for Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 413)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
2
Eplerenone Approved Phase 4 107724-20-9 150310 443872
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Atorvastatin Approved Phase 4 134523-00-5 60823
11
Iodine Approved, Investigational Phase 4 7553-56-2 807
12
Remifentanil Approved Phase 4 132875-61-7 60815
13
Atenolol Approved Phase 4 29122-68-7 2249
14
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
15
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
16
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
17
Enalaprilat Approved Phase 4 76420-72-9 6917719
18
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
19
Enoxaparin Approved Phase 4 9005-49-6 772
20
Ticagrelor Approved Phase 4 274693-27-5 9871419
21
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
22
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
23
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
24
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
25
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
26
Racepinephrine Approved Phase 4 329-65-7 838
27
Desflurane Approved Phase 4 57041-67-5 42113
28
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
31
Ramipril Approved Phase 4 87333-19-5 5362129
32
Glyburide Approved Phase 4 10238-21-8 3488
33
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 23925 27284
34
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
35
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
36
Levetiracetam Approved Phase 4 102767-28-2 441341
37
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
38
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
39
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
40
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
41
Clevidipine Approved, Investigational Phase 4 167221-71-8
42
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
43
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
44
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
45
Tenecteplase Approved Phase 4 191588-94-0
46
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
47 Mineralocorticoids Phase 4
48 Mineralocorticoid Receptor Antagonists Phase 4
49 Antifungal Agents Phase 4
50 Immunologic Factors Phase 4

Interventional clinical trials:

(show top 50) (show all 1426)
# Name Status NCT ID Phase Drugs
1 Comparative Study of Covered Stent With Coil Embolization in the Treatment of Cranial Internal Carotid Artery Aneurysm: A Nonrandomized Prospective Trial Unknown status NCT01029938 Phase 4
2 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
5 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
6 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
7 Multicenter Clinical Study Assessing the Performance and the Safety of the Second Generation Antimicrobial Graft in the Abdominal Position Unknown status NCT00824109 Phase 4
8 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Unknown status NCT02478346 Phase 4 Fluorescein Sodium
9 Evaluation of Closed Incision Negative Pressure Device (Prevena) to Prevent Vascular Wound Complications Unknown status NCT02581904 Phase 4
10 A Prospective Randomized Multicenter Study of the Efficacy and Safety of Systematic Post -Dilatation With Noncompliant Balloon After Successful Drug-eluting Stent Implantation. IVUS Analysis. Unknown status NCT01103765 Phase 4
11 Comparison of the Efficacy of Everolimus-Eluting Versus Sirolimus-Eluting Stent for Coronary Lesions Unknown status NCT00698607 Phase 4 6-month clopidogrel therapy;12-month clopidogrel therapy
12 A Randomised Controlled Trial of the Effectiveness of Ultrasound Guidance in Cannulation of Dialysis Arteriovenous Fistulas and Grafts in a University Hospital Dialysis Unit Unknown status NCT01163981 Phase 4
13 Randomised Clinical Trial to Evaluate the Obtention of Blood Samples Through an Arterial Catheter to Monitor Glycose Levels Unknown status NCT01176279 Phase 4
14 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
15 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
16 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
17 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
18 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
19 A Prospective, Randomized, Multicenter Trial Investigating Matrix 2® and GDC® Detachable Coils for the Treatment of Intracranial Saccular Aneurysms Completed NCT00396981 Phase 4
20 ACE: An Aneurysm Coiling Efficiency Study of the Penumbra Coil 400 System Completed NCT01465841 Phase 4
21 Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry Completed NCT01444664 Phase 4
22 PRET: Patients Prone to Recurrence After Endovascular Treatment. A Randomized Trial Comparing Platinum and Hydrogel-coated Coils Completed NCT00626912 Phase 4
23 Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
24 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
25 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
26 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
27 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
28 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
29 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
30 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
31 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
32 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
33 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
34 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
35 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery. Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
36 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
37 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
38 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
39 Identification and Quantification of the Effects of a Surgery-induced Peripheral Inflammatory Response on Changes in Drug Efflux Transporter Function in the Brain Completed NCT00878371 Phase 4 morphine
40 The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Concentration During General Anesthesia Induction Completed NCT02135016 Phase 4 1% lidocaine;2% lidocaine;0.9% normal saline
41 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed NCT01452256 Phase 4 Desflurane;Propofol
42 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
43 Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD Completed NCT02046460 Phase 4 Acetylsalicylic acid;Vitamin K antagonist
44 Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management Completed NCT01725607 Phase 4 general anesthesia combined with dexmedetomidine infusion
45 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
46 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Completed NCT02097017 Phase 4 Lidocaine
47 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
48 Comparison of Stent Graft, Sirolimus Stent, and Bare Metal Stent Implanted in Patients With Acute Coronary Syndrome: Clinical and Angiographic Follow-up Completed NCT00452517 Phase 4
49 Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study (EVAS): Effect of Eicosapentaenoic Acid on Cerebral Vasospasm Following Subarachnoid Hemorrhage Completed NCT00839449 Phase 4 Eicosapentaenoic acid ethyl ester
50 A Trial of Telmisartan Prevention of Cardiovascular Disease Completed NCT01075698 Phase 4 Non-ARB (standard therapy);ARB (Telmisartan)

Search NIH Clinical Center for Aneurysm

Genetic Tests for Aneurysm

Anatomical Context for Aneurysm

MalaCards organs/tissues related to Aneurysm:

40
Heart, Brain, Kidney, Lung, Testes, Spinal Cord, Endothelial

Publications for Aneurysm

Articles related to Aneurysm:

(show top 50) (show all 57825)
# Title Authors PMID Year
1
Brief review: Pulmonary artery aneurysms and pseudoaneurysms. 61 42
31190207 2019
2
The Emerging Role of the ADAMTS Family in Vascular Diseases. 42
30566059 2018
3
Pulmonary manifestations of large, medium, and variable vessel vasculitis. 42
30509707 2018
4
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. 54 61
20487632 2010
5
Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. 54 61
20212283 2010
6
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation. 54 61
20173550 2010
7
Cathepsin K gene disruption does not affect murine aneurysm formation. 54 61
19775691 2010
8
MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans. 54 61
20177108 2010
9
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. 54 61
20019329 2010
10
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. 54 61
20101093 2010
11
Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B. 54 61
20101701 2010
12
Elastase-induced intracranial aneurysms in hypertensive mice. 54 61
19884566 2009
13
Smooth muscle phenotypic modulation is an early event in aortic aneurysms. 54 61
19931668 2009
14
Aneurysm formation and bradykinin. 54 61
19707733 2009
15
Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. 54 61
19542084 2009
16
Elastin gene study of infants with isolated congenital ductus arteriosus aneurysm. 54 61
19593948 2009
17
Modelling the growth and stabilization of cerebral aneurysms. 54 61
19234094 2009
18
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. 54 61
19304942 2009
19
Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysm. 54 61
18931513 2009
20
Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair. 54 61
20103998 2009
21
Elastin degradation within the abdominal aortic aneurysm wall--relationship between intramural pH and adjacent thrombus formation. 54 61
19021711 2008
22
Ruptured giant aneurysm of the left anterior descending coronary artery in Kawasaki disease. 54 61
18535756 2008
23
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair. 54 61
19238864 2008
24
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. 54 61
18635848 2008
25
Thoracic aortic aneurysm: reading the enemy's playbook. 54 61
18439439 2008
26
A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. 54 61
18389341 2008
27
Bilateral cavernous internal carotid aneurysms in a child with juvenile paget disease and osteoprotegerin deficiency. 54 61
17947367 2008
28
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms. 54 61
17875574 2007
29
Cysteine protease activity in the wall of abdominal aortic aneurysms. 54 61
18155003 2007
30
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. 54 61
17885220 2007
31
Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. 54 61
17721627 2007
32
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays. 54 61
17494658 2007
33
Severe aortic and arterial aneurysms associated with a TGFBR2 mutation. 54 61
17330129 2007
34
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair. 54 61
17277243 2007
35
Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm. 54 61
17714769 2007
36
Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms. 54 61
17198804 2007
37
Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis. 54 61
17182933 2006
38
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. 54 61
17182923 2006
39
Genes predisposing to rapid aneurysm growth. 54 61
17182940 2006
40
Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms. 54 61
16987162 2006
41
The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. 54 61
16961137 2006
42
Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. 54 61
16776339 2006
43
The elevated level of circulating matrix metalloproteinase-9 in patients with abdominal aortic aneurysms decreased to levels equal to those of healthy controls after an aortic repair. 54 61
16779512 2006
44
A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2. 54 61
16476613 2006
45
Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall. 54 61
16136262 2005
46
Genetic basis of thoracic aortic aneurysms and aortic dissections. 54 61
16273536 2005
47
Association of osteoprotegerin with human abdominal aortic aneurysm progression. 54 61
15939823 2005
48
Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. 54 61
15652949 2005
49
Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. 54 61
15561045 2004
50
Rapamycin suppresses experimental aortic aneurysm growth. 54 61
15297830 2004

Variations for Aneurysm

Expression for Aneurysm

Search GEO for disease gene expression data for Aneurysm.

Pathways for Aneurysm

Pathways related to Aneurysm according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
Show member pathways
13.26 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
3
Show member pathways
13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
4
Show member pathways
13.06 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 ELN
5
Show member pathways
12.94 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
6
Show member pathways
12.89 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
7 12.86 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
8
Show member pathways
12.84 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
9
Show member pathways
12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
10
Show member pathways
12.62 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
12
Show member pathways
12.46 PRKG1 MYLK MYH11 ACTA2
13 12.37 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
14
Show member pathways
12.31 TGFB3 TGFB2 MMP12 MFAP5 LOX FBN2
15 12.28 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
16
Show member pathways
12.23 TGFBR2 TGFBR1 TGFB2 SMAD3
17 12.2 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
18 12.17 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
19 12.15 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MMP12
20 12.11 TGFBR1 SMAD3 MYLK ACTA2
21 12.09 TGFBR2 TGFBR1 SMAD3 MMP12
22
Show member pathways
12.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
23
Show member pathways
12.06 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
24 11.89 TGFB3 TGFB2 COL3A1
25 11.89 TGFBR1 TGFB3 TGFB2 NOTCH1
26 11.89 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
27 11.88 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
28
Show member pathways
11.84 TGFBR2 TGFBR1 SMAD3
29 11.82 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
30
Show member pathways
11.81 TGFBR2 TGFBR1 SMAD3 LOX
31 11.73 TGFBR2 TGFBR1 SMAD3
32 11.72 TGFBR2 TGFBR1 SMAD3
33
Show member pathways
11.71 TGFBR2 TGFBR1 SMAD3
34 11.69 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
35 11.62 TGFBR2 TGFBR1 SMAD3
36 11.61 TGFB3 TGFB2 BGN
37
Show member pathways
11.61 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
38 11.58 TGFBR2 TGFBR1 TGFB3 SMAD3
39 11.54 TGFBR2 TGFBR1 TGFB2
40 11.49 TGFBR2 TGFBR1 TGFB3 TGFB2
41 11.39 MYLK MYH11 ACTA2
42
Show member pathways
11.26 TGFBR2 TGFBR1 TGFB3
43 11.24 TGFBR2 TGFBR1 TGFB3
44 11.13 TGFBR2 TGFBR1 SMAD3
45 11.13 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
46 11.04 TGFB3 TGFB2 MYLK FBN2 FBN1 ELN
47
Show member pathways
11.03 TGFB3 TGFB2 MFAP5 LOX FBN2 FBN1
48 10.95 TGFBR2 TGFBR1 SMAD3 FBN2 FBN1

GO Terms for Aneurysm

Cellular components related to Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TGFB3 TGFB2 NOTCH1 MMP12 MFAP5 LOX
2 receptor complex GO:0043235 9.62 TGFBR2 TGFBR1 SMAD3 NOTCH1
3 collagen-containing extracellular matrix GO:0062023 9.56 TGFB3 TGFB2 MFAP5 FBN2 FBN1 ELN
4 microfibril GO:0001527 9.33 MFAP5 FBN2 FBN1
5 extracellular matrix GO:0031012 9.23 MMP12 MFAP5 LOX FBN2 FBN1 ELN

Biological processes related to Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.13 TGFBR2 TGFBR1 TGFB3 TGFB2 NOTCH1
2 positive regulation of gene expression GO:0010628 10.1 TGFBR1 SMAD3 NOTCH1 MMP12 ACTA2
3 negative regulation of cell proliferation GO:0008285 10.1 TGFBR2 TGFB3 TGFB2 SMAD3 NOTCH1
4 positive regulation of cell migration GO:0030335 10.02 TGFBR1 SMAD3 NOTCH1 MYLK
5 regulation of gene expression GO:0010468 10.02 TGFBR2 TGFBR1 NOTCH1 LOX
6 regulation of cell proliferation GO:0042127 9.99 TGFBR2 TGFB3 TGFB2 NOTCH1
7 response to hypoxia GO:0001666 9.97 TGFBR2 TGFB3 TGFB2 SMAD3
8 in utero embryonic development GO:0001701 9.97 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
9 lung development GO:0030324 9.91 TGFBR2 NOTCH1 LOX
10 cell cycle arrest GO:0007050 9.91 TGFBR1 TGFB2 SMAD3 NOTCH1
11 camera-type eye development GO:0043010 9.87 FOXE3 FBN2 FBN1
12 heart looping GO:0001947 9.87 TGFBR2 SMAD3 NOTCH1
13 heart development GO:0007507 9.87 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
14 cellular response to transforming growth factor beta stimulus GO:0071560 9.86 TGFBR1 SMAD3 FBN1
15 SMAD protein signal transduction GO:0060395 9.86 TGFB3 TGFB2 SMAD3
16 embryonic limb morphogenesis GO:0030326 9.85 TGFB2 NOTCH1 FBN2
17 cell development GO:0048468 9.85 TGFB3 TGFB2 FOXE3
18 outflow tract morphogenesis GO:0003151 9.85 TGFBR2 NOTCH1 ELN
19 positive regulation of stress fiber assembly GO:0051496 9.85 TGFBR1 TGFB3 SMAD3
20 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.85 TGFBR2 TGFBR1 TGFB3 SMAD3
21 skeletal system development GO:0001501 9.85 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
22 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.84 TGFBR1 TGFB3 TGFB2
23 lens development in camera-type eye GO:0002088 9.82 TGFBR2 TGFBR1 FOXE3
24 epithelial to mesenchymal transition GO:0001837 9.8 TGFBR1 TGFB2 NOTCH1
25 positive regulation of bone mineralization GO:0030501 9.79 TGFB3 SMAD3 FBN2
26 embryonic cranial skeleton morphogenesis GO:0048701 9.78 TGFBR2 TGFBR1 SMAD3
27 digestive tract development GO:0048565 9.77 TGFBR2 TGFB3 COL3A1
28 extracellular matrix organization GO:0030198 9.76 MMP12 MFAP5 LOX FBN2 FBN1 ELN
29 regulation of epithelial cell proliferation GO:0050678 9.74 SMAD3 NOTCH1
30 cell-cell junction organization GO:0045216 9.74 TGFB3 TGFB2 SMAD3
31 negative regulation of immune response GO:0050777 9.73 TGFB2 COL3A1
32 pulmonary valve morphogenesis GO:0003184 9.73 TGFB2 NOTCH1
33 supramolecular fiber organization GO:0097435 9.73 MFAP5 COL3A1
34 cardiac muscle cell proliferation GO:0060038 9.73 TGFB2 NOTCH1
35 activin receptor signaling pathway GO:0032924 9.73 TGFBR2 TGFBR1 SMAD3
36 collagen fibril organization GO:0030199 9.73 TGFBR1 TGFB2 LOX COL3A1
37 transforming growth factor beta receptor signaling pathway GO:0007179 9.73 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
38 positive regulation of SMAD protein signal transduction GO:0060391 9.72 TGFBR1 TGFB3
39 response to cholesterol GO:0070723 9.72 TGFBR2 TGFBR1
40 somatic stem cell division GO:0048103 9.72 TGFB2 NOTCH1
41 salivary gland morphogenesis GO:0007435 9.71 TGFB3 TGFB2
42 cardiac left ventricle morphogenesis GO:0003214 9.71 TGFBR2 NOTCH1
43 membranous septum morphogenesis GO:0003149 9.71 TGFBR2 TGFB2
44 coronary artery morphogenesis GO:0060982 9.71 TGFBR1 NOTCH1
45 elastic fiber assembly GO:0048251 9.71 MYH11 LOX
46 ventricular trabecula myocardium morphogenesis GO:0003222 9.71 TGFBR1 TGFB2 NOTCH1
47 ventricular septum morphogenesis GO:0060412 9.71 TGFBR2 TGFBR1 TGFB2 NOTCH1
48 embryonic eye morphogenesis GO:0048048 9.7 FBN2 FBN1
49 secondary palate development GO:0062009 9.7 TGFBR2 TGFB3 TGFB2
50 cell growth GO:0016049 9.69 TGFB3 TGFB2

Molecular functions related to Aneurysm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.63 SMAD3 MMP12 LOX
2 transforming growth factor beta receptor binding GO:0005160 9.58 TGFB3 TGFB2 SMAD3
3 SMAD binding GO:0046332 9.56 TGFBR2 TGFBR1 SMAD3 COL3A1
4 activin binding GO:0048185 9.51 TGFBR2 TGFBR1
5 transforming growth factor beta binding GO:0050431 9.5 TGFBR2 TGFBR1 TGFB3
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.49 TGFBR2 TGFBR1
7 type I transforming growth factor beta receptor binding GO:0034713 9.48 TGFBR2 TGFB3
8 transforming growth factor beta-activated receptor activity GO:0005024 9.43 TGFBR2 TGFBR1
9 type III transforming growth factor beta receptor binding GO:0034714 9.37 TGFB3 TGFB2
10 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN2 FBN1 ELN
11 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
12 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN2 FBN1 ELN COL3A1 BGN

Sources for Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....