MCID: ANR040
MIFTS: 59

Aneurysm

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Aneurysm

MalaCards integrated aliases for Aneurysm:

Name: Aneurysm 53 54 62 17 71
Aneurysms 42

Classifications:



External Ids:

UMLS 71 C0002940

Summaries for Aneurysm

NINDS : 53 A cerebral aneurysm is a weak or thin spot on a blood vessel in the brain that balloons out and fills with blood.  A cerebral aneurysm can press on a nerve or surrounding tissue in the brain, and also leak or burst, which lets blood spill into surrounding tissues (called a hemorrhage). Cerebral aneurysms can occur at any age, although they are more common in adults than in children and are more common in women than in men. These aneurysms can occur anywhere in the brain. Some small aneurysms may not show signs and are usually detected during imaging tests for other medical conditions. The signs and symptoms of an unruptured cerebral aneurysm will partly depend on its size and rate of growth. A larger aneurysm that is steadily growing may produce symptoms such as numbness, pain above and behind the eye, and paralysis on one side of the face. Immediately after an aneurysm ruptures, an individual may experience such symptoms as a sudden and unusually severe headache, nausea, vision impairment, vomiting, and loss of consciousness.

MalaCards based summary : Aneurysm, also known as aneurysms, is related to aortic aneurysm, familial abdominal, 1 and aortic aneurysm, familial thoracic 6, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Aneurysm is TGFBR2 (Transforming Growth Factor Beta Receptor 2), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Eplerenone and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and kidney, and related phenotypes are Decreased viability and Decreased viability

MedlinePlus : 42 An aneurysm is a bulge or "ballooning" in the wall of an artery. Arteries are blood vessels that carry oxygen-rich blood from the heart to other parts of the body. If an aneurysm grows large, it can burst and cause dangerous bleeding or even death. Most aneurysms occur in the aorta, the main artery that runs from the heart through the chest and abdomen. Aneurysms also can happen in arteries in the brain, heart and other parts of the body. If an aneurysm in the brain bursts, it causes a stroke. Aneurysms can develop and become large before causing any symptoms. Often doctors can stop aneurysms from bursting if they find and treat them early. They use imaging tests to find aneurysms. Often aneurysms are found by chance during tests done for other reasons. Medicines and surgery are the two main treatments for aneurysms. NIH: National Heart, Lung, and Blood Institute

PubMed Health : 62 About aneurysm: An aneurysm (AN-u-rism) is a balloon-like bulge in an artery. Arteries are blood vessels that carry oxygen-rich blood to your body. Arteries have thick walls to withstand normal blood pressure. However, certain medical problems, genetic conditions, and trauma can damage or injure artery walls. The force of blood pushing against the weakened or injured walls can cause an aneurysm. An aneurysm can grow large and rupture (burst) or dissect. A rupture causes dangerous bleeding inside the body. A dissection is a split in one or more layers of the artery wall. The split causes bleeding into and along the layers of the artery wall. Both rupture and dissection often are fatal.

Wikipedia : 74 An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak... more...

Related Diseases for Aneurysm

Diseases related to Aneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2059)
# Related Disease Score Top Affiliating Genes
1 aortic aneurysm, familial abdominal, 1 34.4 MMP12 FBN1 ELN
2 aortic aneurysm, familial thoracic 6 33.8 TGFBR1 SLC2A10 MYLK MYH11 ACTA2
3 familial abdominal aortic aneurysm 33.6 MYLK FBN1 ELN COL3A1
4 intracranial aneurysm 33.3 TGFBR2 TGFBR1 TGFB2 LOX FBN2 ELN
5 aortic aneurysm, familial thoracic 2 33.2 SLC2A10 FBN2 FBN1 COL3A1 ACTA2
6 autosomal recessive cutis laxa type i 32.6 SLC2A10 FBN1 ELN
7 moyamoya disease 1 32.5 MYLK MYH11 ELN ACTA2
8 loeys-dietz syndrome 4 32.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
9 atrial heart septal defect 32.1 NOTCH1 FBN1 ELN
10 cutis laxa, autosomal dominant 1 32.1 TGFBR2 TGFBR1 SLC2A10 FBN1 ELN
11 loeys-dietz syndrome 3 32.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
12 loeys-dietz syndrome 5 32.0 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
13 patent ductus arteriosus 1 31.7 TGFBR2 TGFBR1 NOTCH1 MYH11 FBN1 ELN
14 loeys-dietz syndrome 1 31.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
15 arterial tortuosity syndrome 31.4 TGFBR2 TGFBR1 TGFB2 SMAD3 SLC2A10 MYH11
16 aortic valve insufficiency 31.0 TGFBR2 TGFBR1 MYH11 FBN1 ELN ACTA2
17 telangiectasis 30.9 TGFBR1 FBN1 ELN
18 varicose veins 30.8 FBN1 ELN COL3A1
19 pulmonary hypertension 30.8 TGFBR2 TGFBR1 SMAD3 PRKG1 ACTA2
20 carotid artery dissection 30.8 MYLK COL3A1
21 inguinal hernia 30.7 LOX FBN1 ELN
22 hereditary hemorrhagic telangiectasia 30.6 TGFBR2 TGFBR1 TGFB2
23 tetralogy of fallot 30.5 NOTCH1 MYH11 FBN1 ELN
24 aortic valve disease 2 30.5 NOTCH1 FBN1 ELN
25 pulsating exophthalmos 30.5 TGFBR2 TGFBR1 COL3A1
26 ehlers-danlos syndrome, vascular type 30.5 ELN COL3A1
27 loeys-dietz syndrome 30.3 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
28 pseudoxanthoma elasticum 30.3 MYH11 FBN1 ELN
29 cutis laxa 30.3 LOX FBN1 ELN
30 mitral valve disease 30.1 TGFB3 TGFB2 FBN1 ELN
31 brittle bone disorder 30.1 FBN1 ELN COL3A1 BGN
32 eisenmenger syndrome 30.0 TGFBR2 TGFBR1
33 craniosynostosis 30.0 TGFBR2 TGFBR1 SMAD3 FBN1
34 ehlers-danlos syndrome 30.0 TGFBR1 SLC2A10 MYH11 FBN2 FBN1 ELN
35 marfan syndrome 30.0 TGFBR2 TGFBR1 TGFB2 NOTCH1 MYLK MYH11
36 aortic aneurysm, familial thoracic 1 29.9 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
37 pulmonary emphysema 29.8 MMP12 LOX ELN
38 familial thoracic aortic aneurysm and aortic dissection 29.7 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
39 exfoliation syndrome 29.6 LOX FBN1 ELN
40 aortic dissection 29.6 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 PRKG1
41 glaucoma, primary open angle 29.6 TGFB2 FBN1 ELN
42 scoliosis 29.5 TGFBR2 TGFB2 LOX FBN2 FBN1 ELN
43 aortic aneurysm 29.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
44 cerebral arterial disease 29.4 ELN COL3A1 ACTA2
45 collagen disease 29.4 TGFBR2 TGFBR1 FBN1 ELN COL3A1 BGN
46 bladder diverticulum 29.4 SLC2A10 LOX ELN
47 pelvic organ prolapse 29.3 LOX FBN1 ELN COL3A1
48 pancreatic adenocarcinoma 28.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
49 orthostatic intolerance 28.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
50 tricuspid valve prolapse 28.3 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10

Graphical network of the top 20 diseases related to Aneurysm:



Diseases related to Aneurysm

Symptoms & Phenotypes for Aneurysm

UMLS symptoms related to Aneurysm:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Aneurysm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00107-A-1 10.16 TGFBR2
2 Decreased viability GR00221-A-1 10.16 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
3 Decreased viability GR00221-A-2 10.16 COL3A1 PRKG1
4 Decreased viability GR00221-A-3 10.16 TGFBR2
5 Decreased viability GR00221-A-4 10.16 COL3A1 MYLK PRKG1 TGFBR1 TGFBR2
6 Decreased viability GR00249-S 10.16 ACTA2 MYLK TGFBR1 TGFBR2
7 Decreased viability GR00301-A 10.16 PRKG1
8 Decreased viability GR00386-A-1 10.16 ELN NOTCH1 SLC2A10 TGFB2
9 Decreased viability GR00402-S-2 10.16 ELN FBN1 FBN2 MFAP5 TGFBR1 TGFBR2

MGI Mouse Phenotypes related to Aneurysm:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACTA2 COL3A1 FBN1 FBN2 LOX MFAP5
2 homeostasis/metabolism MP:0005376 10.31 BGN COL3A1 FBN1 FBN2 LOX MMP12
3 immune system MP:0005387 10.31 BGN COL3A1 FBN1 FBN2 LOX MFAP5
4 cellular MP:0005384 10.3 BGN COL3A1 FBN1 FBN2 MYH11 NOTCH1
5 hematopoietic system MP:0005397 10.3 COL3A1 FBN1 FBN2 LOX MFAP5 MMP12
6 growth/size/body region MP:0005378 10.26 BGN COL3A1 FBN1 FBN2 MYH11 MYLK
7 digestive/alimentary MP:0005381 10.19 COL3A1 MYH11 MYLK NOTCH1 PRKG1 SMAD3
8 mortality/aging MP:0010768 10.17 BGN COL3A1 FBN1 FBN2 LOX MYH11
9 craniofacial MP:0005382 10.11 BGN FBN1 FBN2 NOTCH1 SMAD3 TGFB2
10 integument MP:0010771 10.11 BGN COL3A1 FBN1 FBN2 LOX MMP12
11 muscle MP:0005369 10.07 ACTA2 BGN COL3A1 FBN1 FBN2 LOX
12 renal/urinary system MP:0005367 9.85 FBN1 FBN2 MYH11 MYLK NOTCH1 PRKG1
13 respiratory system MP:0005388 9.73 COL3A1 FBN1 FBN2 LOX MMP12 MYH11
14 skeleton MP:0005390 9.4 BGN FBN1 FBN2 LOX MFAP5 MYLK

Drugs & Therapeutics for Aneurysm

PubMed Health treatment related to Aneurysm: 62

Aortic aneurysms are treated with medicines and surgery . Small aneurysms that are found early and aren’t causing symptoms may not need treatment . Other aneurysms need to be treated. The goals of treatment may include: Preventing the aneurysm from growing Preventing or reversing damage to other body structures Preventing or treating a rupture or dissection Allowing you to continue doing your normal daily activities Treatment for an aortic aneurysm is based on its size. Your doctor may recommend routine testing to make sure an aneurysm isn't getting bigger. This method usually is used for aneurysms that are smaller than 5 centimeters (about 2 inches) across. How often you need testing (for example, every few months or every year) is based on the size of the aneurysm and how fast it's growing. The larger it is and the faster it's growing, the more often you may need to be checked.

Drugs for Aneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 407)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eplerenone Approved Phase 4 107724-20-9 150310 443872
2
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
3
Glyburide Approved Phase 4 10238-21-8 3488
4
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
9
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
10
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
11 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
12
Atenolol Approved Phase 4 29122-68-7 2249
13
Atorvastatin Approved Phase 4 134523-00-5 60823
14
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
15
Iodine Approved, Investigational Phase 4 7553-56-2 807
16
Remifentanil Approved Phase 4 132875-61-7 60815
17
Phenprocoumon Approved, Investigational Phase 4 435-97-2 54680692 9908
18
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
19
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
20
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
21
Enalaprilat Approved Phase 4 76420-72-9 6917719
22
Enoxaparin Approved Phase 4 9005-49-6 772
23
Ticagrelor Approved Phase 4 274693-27-5 9871419
24
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
25
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
26
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
27
Racepinephrine Approved Phase 4 329-65-7 838
28
Desflurane Approved Phase 4 57041-67-5 42113
29
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
30
leucovorin Approved Phase 4 58-05-9 6006 143
31
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
32
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
33
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
34
Adalimumab Approved Phase 4 331731-18-1 16219006
35
Tofacitinib Approved, Investigational Phase 4 477600-75-2
36
Ramipril Approved Phase 4 87333-19-5 5362129
37
Iron Approved, Experimental Phase 4 15438-31-0, 7439-89-6 27284 23925
38
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
39
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
40
Levetiracetam Approved Phase 4 102767-28-2 441341
41
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
42
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
43
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
44
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
45
Clevidipine Approved, Investigational Phase 4 167221-71-8
46
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
47
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
48
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
49
Tenecteplase Approved Phase 4 191588-94-0
50
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 1492)
# Name Status NCT ID Phase Drugs
1 Comparative Study of Covered Stent With Coil Embolization in the Treatment of Cranial Internal Carotid Artery Aneurysm: A Nonrandomized Prospective Trial Unknown status NCT01029938 Phase 4
2 Eplerenone in the Management of Abdominal Aortic Aneurysms: A Proof-Of-Concept Randomised Controlled Trial Unknown status NCT02345590 Phase 4 Eplerenone
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair. A Prospective, Randomised, Controlled Study Unknown status NCT01353443 Phase 4
5 A Randomised Controlled Trial of the Effectiveness of Acetazolamide in Reducing Cerebrospinal Fluid Pressure for Patients Undergoing Thoracic-abdominal Aortic Repair Unknown status NCT01889498 Phase 4 Acetazolamide
6 The Effect of Immunonutrition on Outcome and Postoperative Recovery in Patients Undergoing Elective Surgical Repair of a Thoraco (Abdominal) Aneurysm Aorta Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
7 Multicenter Clinical Study Assessing the Performance and the Safety of the Second Generation Antimicrobial Graft in the Abdominal Position Unknown status NCT00824109 Phase 4
8 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Unknown status NCT02478346 Phase 4 Fluorescein Sodium
9 Device Closure Versus Medical Therapy for Secondary Prevention in Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale : DEFENSE-PFO Unknown status NCT01550588 Phase 4 Standard medical treatment
10 Evaluation of Closed Incision Negative Pressure Device (Prevena) to Prevent Vascular Wound Complications Unknown status NCT02581904 Phase 4
11 A Prospective Randomized Multicenter Study of the Efficacy and Safety of Systematic Post -Dilatation With Noncompliant Balloon After Successful Drug-eluting Stent Implantation. IVUS Analysis. Unknown status NCT01103765 Phase 4
12 A Randomised Controlled Trial of the Effectiveness of Ultrasound Guidance in Cannulation of Dialysis Arteriovenous Fistulas and Grafts in a University Hospital Dialysis Unit Unknown status NCT01163981 Phase 4
13 Comparison of the Efficacy of Everolimus-Eluting Versus Sirolimus-Eluting Stent for Coronary Lesions Unknown status NCT00698607 Phase 4 6-month clopidogrel therapy;12-month clopidogrel therapy
14 Randomised Clinical Trial to Evaluate the Obtention of Blood Samples Through an Arterial Catheter to Monitor Glycose Levels Unknown status NCT01176279 Phase 4
15 Glibenclamide in Aneurysmatic Subarachnoid Hemorrhage: A Prospective and Randomized Study Unknown status NCT03569540 Phase 4 Glibenclamide
16 Study Using Plasma for Patients Requiring Emergency Surgery: A Randomized Pilot Trial of Early Plasma for Patients Undergoing Emergency Surgery for Hemorrhagic Shock Unknown status NCT01221389 Phase 4 Human Plasma
17 Endovascular Treatment of Thoracic Aortic Aneurysms Using the TALENT Stent Graft System Completed NCT00802984 Phase 4
18 A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis - Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Completed NCT00593814 Phase 4
19 TALENT Endoluminal Stent Graft System for the Treatment of Abdominal Aortic Aneurysms Completed NCT00803075 Phase 4
20 Study of the Effectiveness of Telmisartan in Slowing the Progression of Abdominal Aortic Aneurysms Completed NCT01683084 Phase 4 Telmisartan;Placebo
21 A Prospective, Randomized, Multicenter Trial Investigating Matrix 2® and GDC® Detachable Coils for the Treatment of Intracranial Saccular Aneurysms Completed NCT00396981 Phase 4
22 ACE: An Aneurysm Coiling Efficiency Study of the Penumbra Coil 400 System Completed NCT01465841 Phase 4
23 Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry Completed NCT01444664 Phase 4
24 PRET: Patients Prone to Recurrence After Endovascular Treatment. A Randomized Trial Comparing Platinum and Hydrogel-coated Coils Completed NCT00626912 Phase 4
25 Sevoflurane, Laryngeal Mask Airway and Single-dose Dexmedetomidine: A Better Choice for Patients Undergoing Endovascular Coil Embolization Completed NCT01722409 Phase 4 sevoflurane and 0.5 μg/kg dexmedetomidine;sevoflurane and 1 μg/kg dexmedetomidine
26 Prevalence of Abdominal Aortic Aneurysm in Patients Undergoing Coronary Angiography Completed NCT01239225 Phase 4
27 CUstodiol Versus RInger: whaT Is the Best Agent? A Randomized Double Blind Trial. Completed NCT02327611 Phase 4 Custodiol;Enriched Ringer's lactate solution
28 Coagulopathy During Surgery for the Repair of Extent 4 Thoraco-Abdominal Aortic Aneurysms - Feasibility Study of the Use of Fibrinogen Concentrate by Infusion in Place of Fresh Frozen Plasma. Completed NCT00994045 Phase 4
29 Opioid-potentiated Volative Anaesthetic(Sevoflurane)Compared to Remifentanil and Propofol During Abdominal Aortic Aneurysm Surgery Completed NCT00538421 Phase 4 Propofol;Sevoflurane
30 CSP #498 - Open Versus Endovascular Repair (OVER) Trial for Abdominal Aortic Aneurysms Completed NCT00094575 Phase 4
31 Transversus Abdominis Plane (TAP) Block in Open Abdominal Aortic Surgery : Randomized Controlled Doubled-blind Trial Comparing Ropivacaine 0.2% Versus Placebo Completed NCT03657979 Phase 4 Ropivacaine;Placebo
32 Multicenter, Randomized, Open Study, Investigator-initiated Trial for Comparison of Eight Weeks Efficacy and Tolerability of Clopirin and Clopidogrel With Aspirin in Korean Patients With Post-Percutaneous Coronary Artery Intervention Completed NCT02410083 Phase 4 Clopirin 1;Clopidogrel-Aspirin(co-administration) 1;Clopirin 2;Clopidogrel-Aspirin(co-administration) 2
33 Impact of Carotid Plaque Screening on Smoking Cessation and Control of Other Cardiovascular Risk Factors: A Randomized Controlled Trial. Completed NCT00548665 Phase 4
34 Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities. Completed NCT02107170 Phase 4 Sevoflurane;Propofol;Remifentanil
35 Comparison of High Iodine Concentration Contrast Material (Isovue 370) vs Standard Protocol (Isovue 300) in Thoracoabdominal Aortic Computed Tomographic Angiography (CTA) for Radiation Dose Reduction Completed NCT02291718 Phase 4 Isovue
36 Comparison of Beta-blocker Versus Angiotensin Receptor Blocker for Suppression of Aneurysm Expansion in Patients With Small Abdominal Aortic Aneurysm and Hypertension (BASE Trial) Completed NCT01904981 Phase 4 Beta-blocker-Atenolol 50mg, PO(peroral), Once daily;Angiotensin receptor blocker-Valsartan 80mg, PO(peroral), Once daily
37 Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function in Patients Undergoing Intracranial Aneurysm Surgery. Completed NCT02691416 Phase 4 propofol postconditioning;sevoflurane
38 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
39 Randomised Controlled Trial of Effect of Pre-operative Statin Use on Matrix Metalloproteinases (MMP) & Tissue Inhibitors of Matrix Metalloproteinases (TIMP) in Abdominal Aortic Aneurysm (AAA). Completed NCT01062802 Phase 4 Atorvastatin
40 Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial. Completed NCT02335359 Phase 4 tranexamic acid diluted in 100 ml of saline solution (loading dose);tranexamic acid undiluted (continous infusion);Placebo
41 Identification and Quantification of the Effects of a Surgery-induced Peripheral Inflammatory Response on Changes in Drug Efflux Transporter Function in the Brain Completed NCT00878371 Phase 4 morphine
42 Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture Completed NCT03231397 Phase 4 Assess AAA rupture risk by PET-CTA scans;18F-fludeoxyglucose (FDG)
43 The Effect of Thoracic Epidural Anesthesia With Different Block Level on Propofol Concentration During General Anesthesia Induction Completed NCT02135016 Phase 4 1% lidocaine;2% lidocaine;0.9% normal saline
44 A Controlled Trial of Effectiveness of a Backward Walking Program in Patients Recovering From an Abdominal Aorta Surgery Completed NCT00819936 Phase 4
45 Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD Completed NCT02046460 Phase 4 Acetylsalicylic acid;Vitamin K antagonist
46 Atorvastatin 80mg Versus Atorvastatin 20mg in Perioperative Vascular Surgery to Evaluate Cardiovascular Outcomes Completed NCT00610545 Phase 4 Atorvastatin;Atorvastatin
47 Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management Completed NCT01725607 Phase 4 general anesthesia combined with dexmedetomidine infusion
48 Desflurane and Its Effect on Postoperative Morbidity and Mortality in Patients Undergoing Thoracic Surgery Completed NCT01452256 Phase 4 Desflurane;Propofol
49 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
50 Prophylactic Lidocaine Spray for Pain Alleviation in Women Undergoing Osmotic Dilator Insertion for Second Trimester Dilatation and Evacuation Completed NCT02097017 Phase 4 Lidocaine

Search NIH Clinical Center for Aneurysm

Genetic Tests for Aneurysm

Anatomical Context for Aneurysm

MalaCards organs/tissues related to Aneurysm:

40
Brain, Heart, Kidney, Lung, Testes, Spinal Cord, Endothelial

Publications for Aneurysm

Articles related to Aneurysm:

(show top 50) (show all 58098)
# Title Authors PMID Year
1
The Origins of Eponymous Aneurysm Clips: A Review. 42 61
31542444 2020
2
Transesophageal Echocardiogram to the Rescue in Diagnosing Ascending Aortic Pseudoaneurysm. 42
31834873 2020
3
A Pilot Study of a Standardized Smoking Cessation Intervention for Patients with Vascular Disease. 42
31449932 2019
4
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. 54 61
20487632 2010
5
Cathepsin K gene disruption does not affect murine aneurysm formation. 61 54
19775691 2010
6
MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans. 61 54
20177108 2010
7
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation. 54 61
20173550 2010
8
Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. 61 54
20212283 2010
9
TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. 61 54
20101093 2010
10
Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B. 61 54
20101701 2010
11
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. 54 61
20019329 2010
12
Elastase-induced intracranial aneurysms in hypertensive mice. 54 61
19884566 2009
13
Smooth muscle phenotypic modulation is an early event in aortic aneurysms. 54 61
19931668 2009
14
Aneurysm formation and bradykinin. 54 61
19707733 2009
15
Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations. 61 54
19542084 2009
16
Modelling the growth and stabilization of cerebral aneurysms. 54 61
19234094 2009
17
Elastin gene study of infants with isolated congenital ductus arteriosus aneurysm. 54 61
19593948 2009
18
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. 54 61
19304942 2009
19
Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair. 54 61
20103998 2009
20
Ruptured giant aneurysm of the left anterior descending coronary artery in Kawasaki disease. 61 54
18535756 2008
21
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair. 54 61
19238864 2008
22
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. 61 54
18635848 2008
23
Thoracic aortic aneurysm: reading the enemy's playbook. 54 61
18439439 2008
24
A novel COL3A1 gene mutation in patient with aortic dissected aneurysm and cervical artery dissections. 61 54
18389341 2008
25
Bilateral cavernous internal carotid aneurysms in a child with juvenile paget disease and osteoprotegerin deficiency. 54 61
17947367 2008
26
An increased frequency of the 5A allele in the promoter region of the MMP3 gene is associated with abdominal aortic aneurysms. 61 54
17875574 2007
27
Cysteine protease activity in the wall of abdominal aortic aneurysms. 54 61
18155003 2007
28
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model. 61 54
17885220 2007
29
Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. 61 54
17721627 2007
30
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays. 61 54
17494658 2007
31
Severe aortic and arterial aneurysms associated with a TGFBR2 mutation. 61 54
17330129 2007
32
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair. 61 54
17277243 2007
33
Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms. 54 61
17198804 2007
34
Matrix metalloproteinases and tissue inhibitors of metalloproteinases expression in human cerebral ruptured and unruptured aneurysm. 54 61
17714769 2007
35
Genes predisposing to rapid aneurysm growth. 54 61
17182940 2006
36
Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds. 54 61
17182923 2006
37
Matrix metalloproteinase-2: the forgotten enzyme in aneurysm pathogenesis. 61 54
17182933 2006
38
Matrix metalloproteinases 2 and 9 in human atherosclerotic and non-atherosclerotic cerebral aneurysms. 61 54
16987162 2006
39
The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. 61 54
16961137 2006
40
Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. 61 54
16776339 2006
41
The elevated level of circulating matrix metalloproteinase-9 in patients with abdominal aortic aneurysms decreased to levels equal to those of healthy controls after an aortic repair. 61 54
16779512 2006
42
A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2. 54 61
16476613 2006
43
Intracranial arterial aneurysm vasculopathies: targeting the outer vessel wall. 61 54
16136262 2005
44
Genetic basis of thoracic aortic aneurysms and aortic dissections. 61 54
16273536 2005
45
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm. 54 61
15918165 2005
46
Association of osteoprotegerin with human abdominal aortic aneurysm progression. 54 61
15939823 2005
47
Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. 61 54
15652949 2005
48
Smoking promotes pathogenesis of aortic aneurysm through the 5-lipoxygenase pathway. 54 61
15823697 2005
49
Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. 54 61
15561045 2004
50
Heterogeneity of tensile strength and matrix metalloproteinase activity in the wall of abdominal aortic aneurysms. 61 54
15298501 2004

Variations for Aneurysm

Expression for Aneurysm

Search GEO for disease gene expression data for Aneurysm.

Pathways for Aneurysm

Pathways related to Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
2
Show member pathways
13.68 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
3
Show member pathways
13.28 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
4
Show member pathways
13.24 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK MYH11
5
Show member pathways
13.06 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 ELN
6
Show member pathways
12.95 TGFBR2 TGFBR1 TGFB3 TGFB2 PRKG1 MYH11
7
Show member pathways
12.89 TGFBR2 TGFBR1 TGFB3 TGFB2 MYLK ACTA2
8 12.86 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
9
Show member pathways
12.85 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
10
Show member pathways
12.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
11
Show member pathways
12.62 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
12
Show member pathways
12.5 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
13
Show member pathways
12.47 PRKG1 MYLK MYH11 ACTA2
14 12.37 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
15
Show member pathways
12.31 TGFB3 TGFB2 MMP12 MFAP5 LOX FBN2
16 12.27 TGFBR1 TGFB3 TGFB2 SMAD3 NOTCH1
17
Show member pathways
12.23 TGFBR2 TGFBR1 TGFB2 SMAD3
18 12.19 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
19 12.17 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20 12.17 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 MMP12
21 12.11 TGFBR1 SMAD3 MYLK ACTA2
22 12.09 TGFBR2 TGFBR1 SMAD3 MMP12
23
Show member pathways
12.09 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
24 11.92 TGFB3 TGFB2 BGN ACTA2
25 11.92 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
26 11.89 TGFB3 TGFB2 COL3A1
27 11.89 TGFBR1 TGFB3 TGFB2 NOTCH1
28
Show member pathways
11.88 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
29 11.88 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
30
Show member pathways
11.84 TGFBR2 TGFBR1 SMAD3
31 11.82 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
32
Show member pathways
11.81 TGFBR2 TGFBR1 SMAD3 LOX
33 11.73 TGFBR2 TGFBR1 SMAD3
34 11.72 TGFBR2 TGFBR1 SMAD3
35
Show member pathways
11.71 TGFBR2 TGFBR1 SMAD3
36 11.7 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 ACTA2
37
Show member pathways
11.64 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
38 11.63 TGFBR2 TGFBR1 SMAD3
39 11.62 TGFB3 TGFB2 BGN
40 11.58 TGFBR2 TGFBR1 TGFB3 SMAD3
41 11.55 TGFBR2 TGFBR1 TGFB2
42 11.4 MYLK MYH11 ACTA2
43
Show member pathways
11.26 TGFBR2 TGFBR1 TGFB3
44 11.24 TGFBR2 TGFBR1 TGFB3
45 11.13 TGFBR2 TGFBR1 SMAD3
46 11.13 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
47 11.05 TGFB3 TGFB2 MYLK FBN2 FBN1 ELN
48
Show member pathways
11.03 TGFB3 TGFB2 MFAP5 LOX FBN2 FBN1
49 10.96 TGFBR2 TGFBR1 TGFB3 TGFB2
50 10.95 TGFBR2 TGFBR1 SMAD3 FBN2 FBN1

GO Terms for Aneurysm

Cellular components related to Aneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TGFB3 TGFB2 NOTCH1 MMP12 MFAP5 LOX
2 extracellular space GO:0005615 9.97 TGFB3 TGFB2 MMP12 LOX FBN1 COL3A1
3 receptor complex GO:0043235 9.62 TGFBR2 TGFBR1 SMAD3 NOTCH1
4 collagen-containing extracellular matrix GO:0062023 9.56 TGFB3 TGFB2 MFAP5 FBN2 FBN1 ELN
5 microfibril GO:0001527 9.33 MFAP5 FBN2 FBN1
6 extracellular matrix GO:0031012 9.23 MMP12 MFAP5 LOX FBN2 FBN1 ELN

Biological processes related to Aneurysm according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.12 TGFBR2 TGFBR1 TGFB3 TGFB2 NOTCH1
2 negative regulation of cell proliferation GO:0008285 10.1 TGFBR2 TGFB3 TGFB2 SMAD3 NOTCH1
3 positive regulation of gene expression GO:0010628 10.08 TGFBR1 SMAD3 SLC2A10 NOTCH1 MMP12 ACTA2
4 positive regulation of cell migration GO:0030335 10.02 TGFBR1 SMAD3 NOTCH1 MYLK
5 regulation of cell proliferation GO:0042127 10 TGFBR2 TGFB3 TGFB2 NOTCH1
6 response to hypoxia GO:0001666 9.97 TGFBR2 TGFB3 TGFB2 SMAD3
7 in utero embryonic development GO:0001701 9.97 TGFBR2 TGFBR1 TGFB3 SMAD3 NOTCH1
8 cell cycle arrest GO:0007050 9.92 TGFBR1 TGFB2 SMAD3 NOTCH1
9 muscle contraction GO:0006936 9.91 MYLK MYH11 ACTA2
10 lung development GO:0030324 9.9 TGFBR2 NOTCH1 LOX
11 skeletal system development GO:0001501 9.89 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
12 heart looping GO:0001947 9.87 TGFBR2 SMAD3 NOTCH1
13 camera-type eye development GO:0043010 9.87 FOXE3 FBN2 FBN1
14 blood vessel development GO:0001568 9.87 TGFBR2 LOX COL3A1
15 heart development GO:0007507 9.87 TGFBR2 TGFBR1 TGFB2 NOTCH1 LOX FBN1
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.86 TGFBR1 SMAD3 FBN1
17 SMAD protein signal transduction GO:0060395 9.86 TGFB3 TGFB2 SMAD3
18 embryonic limb morphogenesis GO:0030326 9.85 TGFB2 NOTCH1 FBN2
19 outflow tract morphogenesis GO:0003151 9.85 TGFBR2 NOTCH1 ELN
20 positive regulation of stress fiber assembly GO:0051496 9.85 TGFBR1 TGFB3 SMAD3
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.83 TGFBR1 TGFB3 TGFB2
22 lens development in camera-type eye GO:0002088 9.83 TGFBR2 TGFBR1 FOXE3
23 epithelial to mesenchymal transition GO:0001837 9.83 TGFBR1 TGFB2 NOTCH1
24 positive regulation of bone mineralization GO:0030501 9.8 TGFB3 SMAD3 FBN2
25 embryonic cranial skeleton morphogenesis GO:0048701 9.79 TGFBR2 TGFBR1 SMAD3
26 digestive tract development GO:0048565 9.78 TGFBR2 TGFB3 COL3A1
27 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.77 TGFBR2 TGFBR1 TGFB3 SMAD3 SLC2A10
28 cell-cell junction organization GO:0045216 9.76 TGFB3 TGFB2 SMAD3
29 collagen fibril organization GO:0030199 9.76 TGFBR1 TGFB2 LOX COL3A1
30 extracellular matrix organization GO:0030198 9.76 MMP12 MFAP5 LOX FBN2 FBN1 ELN
31 activin receptor signaling pathway GO:0032924 9.74 TGFBR2 TGFBR1 SMAD3
32 regulation of epithelial cell proliferation GO:0050678 9.73 SMAD3 NOTCH1
33 positive regulation of SMAD protein signal transduction GO:0060391 9.73 TGFBR1 TGFB3
34 pulmonary valve morphogenesis GO:0003184 9.73 TGFB2 NOTCH1
35 ventricular trabecula myocardium morphogenesis GO:0003222 9.73 TGFBR1 TGFB2 NOTCH1
36 ventricular septum morphogenesis GO:0060412 9.73 TGFBR2 TGFBR1 TGFB2 NOTCH1
37 transforming growth factor beta receptor signaling pathway GO:0007179 9.73 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
38 cardiac muscle cell proliferation GO:0060038 9.72 TGFB2 NOTCH1
39 supramolecular fiber organization GO:0097435 9.72 MFAP5 COL3A1
40 response to cholesterol GO:0070723 9.72 TGFBR2 TGFBR1
41 secondary palate development GO:0062009 9.72 TGFBR2 TGFB3 TGFB2
42 elastic fiber assembly GO:0048251 9.71 MYH11 LOX
43 somatic stem cell division GO:0048103 9.71 TGFB2 NOTCH1
44 salivary gland morphogenesis GO:0007435 9.71 TGFB3 TGFB2
45 cardiac left ventricle morphogenesis GO:0003214 9.71 TGFBR2 NOTCH1
46 membranous septum morphogenesis GO:0003149 9.71 TGFBR2 TGFB2
47 pathway-restricted SMAD protein phosphorylation GO:0060389 9.71 TGFBR2 TGFBR1 TGFB2
48 coronary artery morphogenesis GO:0060982 9.7 TGFBR1 NOTCH1
49 cardiac epithelial to mesenchymal transition GO:0060317 9.7 TGFBR1 TGFB2 NOTCH1
50 atrioventricular valve morphogenesis GO:0003181 9.69 TGFBR2 TGFB2 NOTCH1

Molecular functions related to Aneurysm according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 collagen binding GO:0005518 9.61 SMAD3 MMP12 LOX
2 SMAD binding GO:0046332 9.56 TGFBR2 TGFBR1 SMAD3 COL3A1
3 transforming growth factor beta binding GO:0050431 9.54 TGFBR2 TGFBR1 TGFB3
4 activin binding GO:0048185 9.51 TGFBR2 TGFBR1
5 transforming growth factor beta receptor binding GO:0005160 9.5 TGFB3 TGFB2 SMAD3
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.49 TGFBR2 TGFBR1
7 type I transforming growth factor beta receptor binding GO:0034713 9.48 TGFBR2 TGFB3
8 transforming growth factor beta-activated receptor activity GO:0005024 9.46 TGFBR2 TGFBR1
9 type III transforming growth factor beta receptor binding GO:0034714 9.4 TGFB3 TGFB2
10 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN2 FBN1 ELN
11 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
12 extracellular matrix structural constituent GO:0005201 9.1 MFAP5 FBN2 FBN1 ELN COL3A1 BGN

Sources for Aneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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