SVA
MCID: ANR010
MIFTS: 30

Aneurysm of Sinus of Valsalva (SVA)

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Aneurysm of Sinus of Valsalva

MalaCards integrated aliases for Aneurysm of Sinus of Valsalva:

Name: Aneurysm of Sinus of Valsalva 52 58 71
Sinus of Valsalva Aneurysm 52
Sva 52

Characteristics:

Orphanet epidemiological data:

58
aneurysm of sinus of valsalva
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare cardiac malformations
Developmental anomalies during embryogenesis


Summaries for Aneurysm of Sinus of Valsalva

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 1054 Definition Sinus of Valsalva aneurysm (SVA) is a rare congenital heart malformation of one or more of the aortic sinuses, consisting of a dilation that when unruptured is usually asymptomatic but when ruptured presents with progressive exertional dyspnea, fatigue, chest pain and that can lead to congestive heart failure if left untreated. Visit the Orphanet disease page for more resources.

MalaCards based summary : Aneurysm of Sinus of Valsalva, also known as sinus of valsalva aneurysm, is related to dystonia 3, torsion, x-linked and williams-beuren syndrome. Affiliated tissues include heart, kidney and lung, and related phenotypes are dilatation of the sinus of valsalva and dyspnea

Wikipedia : 74 Aneurysm of the aortic sinus, also known as the sinus of Valsalva, is a rare abnormality of the aorta,... more...

Related Diseases for Aneurysm of Sinus of Valsalva

Diseases related to Aneurysm of Sinus of Valsalva via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 dystonia 3, torsion, x-linked 11.6
2 williams-beuren syndrome 11.2
3 aneurysm 10.8
4 supravalvular aortic stenosis 10.7
5 aortic valve insufficiency 10.7
6 ischemia 10.6
7 acute myocardial infarction 10.5
8 endocarditis 10.5
9 heart septal defect 10.5
10 ventricular septal defect 10.5
11 aortic dissection 10.5
12 infective endocarditis 10.4
13 patent ductus arteriosus 1 10.4
14 myocardial infarction 10.4
15 cardiac conduction defect 10.4
16 heart disease 10.4
17 marfan syndrome 10.4
18 down syndrome 10.3
19 aortic valve disease 2 10.3
20 patent foramen ovale 10.3
21 syphilis 10.3
22 47,xyy 10.3
23 cardiogenic shock 10.3
24 aortic valve disease 1 10.3
25 tricuspid valve insufficiency 10.3
26 progressive familial heart block, type ia 10.3
27 ventricular fibrillation, paroxysmal familial, 1 10.3
28 progressive familial heart block, type ib 10.3
29 pulmonary hypertension 10.3
30 right bundle branch block 10.3
31 myocarditis 10.3
32 suppression amblyopia 10.3
33 amblyopia 10.3
34 albinism 10.3
35 tetralogy of fallot 10.2
36 brittle bone disorder 10.2
37 angina pectoris 10.2
38 arteries, anomalies of 10.2
39 cardiac arrhythmia 10.2
40 hyperlipoproteinemia, type iii 10.2
41 lipoprotein quantitative trait locus 10.2
42 atrioventricular block 10.2
43 second-degree atrioventricular block 10.2
44 cardiac arrest 10.2
45 dextro-looped transposition of the great arteries 10.2
46 ehlers-danlos syndrome 10.2
47 toxic shock syndrome 10.2
48 coronary aneurysm 10.2
49 tricuspid valve stenosis 10.2
50 heart valve disease 10.2

Graphical network of the top 20 diseases related to Aneurysm of Sinus of Valsalva:



Diseases related to Aneurysm of Sinus of Valsalva

Symptoms & Phenotypes for Aneurysm of Sinus of Valsalva

Human phenotypes related to Aneurysm of Sinus of Valsalva:

58 31 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dilatation of the sinus of valsalva 58 31 obligate (100%) Obligate (100%) HP:0011645
2 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
3 aortic regurgitation 58 31 frequent (33%) Frequent (79-30%) HP:0001659
4 heart murmur 58 31 frequent (33%) Frequent (79-30%) HP:0030148
5 edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0000969
6 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
7 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
8 chest pain 58 31 very rare (1%) Very rare (<4-1%) HP:0100749
9 stroke 58 31 very rare (1%) Very rare (<4-1%) HP:0001297
10 oliguria 58 31 very rare (1%) Very rare (<4-1%) HP:0100520
11 bacterial endocarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0006689

Drugs & Therapeutics for Aneurysm of Sinus of Valsalva

Search Clinical Trials , NIH Clinical Center for Aneurysm of Sinus of Valsalva

Genetic Tests for Aneurysm of Sinus of Valsalva

Anatomical Context for Aneurysm of Sinus of Valsalva

MalaCards organs/tissues related to Aneurysm of Sinus of Valsalva:

40
Heart, Kidney, Lung, Testes

Publications for Aneurysm of Sinus of Valsalva

Articles related to Aneurysm of Sinus of Valsalva:

(show top 50) (show all 864)
# Title Authors PMID Year
1
Right sinus of Valsalva aneurysm. 61
32145675 2020
2
Unruptured Sinus of Valsalva Aneurysm Causing Complete Atrioventricular Block: A Case Report. 61
31987797 2020
3
A ventricular septal defect with a continuous left-to-right shunt mimicking a ruptured sinus of Valsalva aneurysm. 61
32519979 2020
4
Surgical repair of a quadricuspid aortic valve associated with a ruptured sinus of Valsalva aneurysm. 61
31409494 2020
5
Giant right sinus of Valsalva aneurysm led to proximal right coronary artery occlusion. 61
32478685 2020
6
Ruptured Coronary Sinus of Valsalva in the Setting of a Supracristal Ventricular Septal Defect. 61
32426659 2020
7
Giant sinus of Valsalva aneurysm mimicking severe pulmonary hypertension. 61
32388816 2020
8
Unusual presentation and rupture of left sinus of Valsalva into mitral-aortic intervalvular fibrosa. 61
32058603 2020
9
Sudden Cardiac Death in a Patient with Anomalous Origin of Right Coronary Artery with Concomitant Sinus of Valsalva Aneurysm. 61
32328387 2020
10
A Case of Sinus of Valsalva Aneurysm Rupture in a Patient with Bicuspid Aortic Valve. 61
32099944 2020
11
Percutaneous closure of ruptured noncoronary sinus of Valsalva to right atrium causing severe right heart failure, a case report. 61
32042359 2020
12
Impact of Intraoperative Transesophageal Echocardiography for Noncoronary Sinus of Valsalva Aneurysm With Severe Tricuspid Regurgitation. 61
32224023 2020
13
Acute rupture of a sinus of Valsalva aneurysm into the right atrium: a case report and a narrative review. 61
32070284 2020
14
Rare Presentation of a Ruptured Sinus of Valsalva Aneurysm. 61
32090190 2020
15
Noncoronary sinus of Valsalva aneurysm resembling a cystic cardiac mass. 61
31981234 2020
16
Ruptured Sinus of Valsalva Aneurysm Presenting as Acute Coronary Syndrome with Cardiogenic Shock and aVR ST-Elevation - A Case Report. 61
31903012 2020
17
Unruptured Multiple Sinus of Valsalva Aneurysms. 61
32550036 2020
18
Giant unruptured sinus of Valsalva aneurysm successfully managed with valve-sparing procedure - a case report. 61
31915041 2020
19
Management of ruptured sinus of valsalva for device closure in a patient with haemophilia. 61
31929254 2020
20
Ruptured Sinus of Valsalva Aneurysm Causing Aorto-Atrial Fistula and Acute Heart Failure: A Rare Encounter. 61
32309258 2020
21
Multi-modality Imaging of Cocaine-induced Rupture of Sinus of Valsalva Aneurysm Communicating with Tricuspid Valve Annulus. 61
32052603 2019
22
Giant Unruptured Sinus of Valsalva Aneurysm: A Rare One Arise From Left Sinus. 61
31637936 2019
23
Sinus of Valsalva aneurysm protruding into the mitral anterior leaflet causing dyspnea: A CARE-compliant case report. 61
31770266 2019
24
A rare ruptured giant non-coronary sinus of Valsalva aneurysm. 61
31633163 2019
25
Left sinus of Valsalva aneurysm rupturing into superior vena cava. 61
31533440 2019
26
[Giant Aneurysm of Sinus of Valsalva;Report of a Case]. 61
31588113 2019
27
Medium- and long-term follow-up of transcatheter closure of ruptured sinus of Valsalva aneurysm in Central Europe population. 61
31023567 2019
28
Ruptured Sinus of Valsalva Aneurysm Mimicking Infective Endocarditis in DiGeorge Syndrome. 61
32090000 2019
29
Percutaneous transcatheter closure of ruptured sinus of Valsalva aneurysm. 61
31483313 2019
30
Different Manifestations of Rare Cases of Unruptured Sinus of Valsalva Aneurysm-Case Series and Literature Review. 61
31452589 2019
31
The value of three-dimensional echocardiography in the diagnosis and management of ruptured sinus of Valsalva aneurysm: a case report. 61
31660486 2019
32
Cardiac Methotrexate-Induced Lymphoproliferative Disorder. 61
30853590 2019
33
Sinus of valsalva aneurysm: three different presentations, three different solutions. 61
31558104 2019
34
Sinus of Valsalva Aneurysm Causing Compression of the Left Anterior Descending Artery Resulting in Angina. 61
31422091 2019
35
An unusual association of sinus of Valsalva aneurysm with pulmonary atresia and intact ventricular septum. 61
31582351 2019
36
Multimodality imaging for diagnosis and procedural planning for a ruptured sinus of Valsalva aneurysm. 61
31587967 2019
37
Rupture of Sinus of Valsalva Aneurysm into Interventricular Septum: Role of Cardiac CT. 61
31696007 2019
38
Transcatheter Aortic Valve Replacement in a Sinus of Valsalva Aneurysm: The Evolving Role of Structural Cardiac Imaging. 61
31451007 2019
39
Peratrial Device Closure of Ruptured Sinus of Valsalva Aneurysm Into Right Atrium. 61
30951690 2019
40
Florida sleeve technique for a right sinus of Valsalva aneurysm: a case report. 61
31385066 2019
41
Surgery following Extracorporeal Cardiopulmonary Resuscitation in a Patient with an Extracardiac Rupture of Valsalva Sinus Aneurysm. 61
31398093 2019
42
Surgical Repair of a Sinus of Valsalva Aneurysm: A 22-Year Single-Center Experience. 61
31299696 2019
43
Surgical repair of a ruptured congenital sinus of Valsalva aneurysm: 10-year experience with 286 cases. 61
30624624 2019
44
Giant unruptured aneurysm of the left coronary sinus of Valsalva presenting as acute coronary syndrome: a case report. 61
31449599 2019
45
[Aortic Valve-preserving Root Remodeling in a Patient with Bicuspid Aortic Valve and Severe Annulo-aortic Ectasia]. 61
31268014 2019
46
Sinus of Valsalva aneurysm repairs: Operative technique and lessons learned. 61
30953447 2019
47
Transcatheter Closure of Ruptured Sinus of Valsalva Aneurysm with Double-Disc Perimembranous VSD Occluder in Man with Mechanical Aortic Valve. 61
31708706 2019
48
Rare case of ruptured sinus of Valsalva aneurysm presenting only with diastolic murmur: cine mode reconstruction of cardiac computed tomography revealed flap motion of rupture site. 61
31449656 2019
49
The role of echocardiography in the diagnosis and management of a giant unruptured sinus of Valsalva aneurysm. 61
31063525 2019
50
Right sinus of Valsalva aneurysm spontaneously dissecting into the interventricular septum in a rare case of Behcet's disease. 61
30629150 2019

Variations for Aneurysm of Sinus of Valsalva

Expression for Aneurysm of Sinus of Valsalva

Search GEO for disease gene expression data for Aneurysm of Sinus of Valsalva.

Pathways for Aneurysm of Sinus of Valsalva

GO Terms for Aneurysm of Sinus of Valsalva

Sources for Aneurysm of Sinus of Valsalva

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
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30 HMDB
31 HPO
32 ICD10
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35 IUPHAR
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39 LOVD
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43 MeSH
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48 NCI
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57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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