MCID: ANR009
MIFTS: 49

Aneurysmal Bone Cysts

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 57 38 53 13
Aneurysmal Bone Cyst 59 29
Bone Cysts, Aneurysmal 73
Bone Cysts Aneurysmal 55

Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

OMIM 57 606179
Orphanet 59 ORPHA480553
MedGen 42 C0152244
ICD10 33 M85.5
UMLS 73 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to giant cell tumor and giant cell reparative granuloma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 76 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.5 CALCA TNFRSF11A TNFSF11
2 giant cell reparative granuloma 30.3 CALCA TNFRSF11A USP6
3 bone giant cell tumor 30.0 CALCA TNFSF11
4 tooth resorption 29.6 TNFRSF11A TNFSF11
5 fibrous dysplasia 10.6
6 chondroblastoma 10.5
7 osteoblastoma 10.4
8 ossifying fibroma 10.3
9 degos 'en cocarde' erythrokeratoderma 10.2
10 telangiectatic osteogenic sarcoma 10.2
11 chondromyxoid fibroma 10.1
12 paraplegia 10.1
13 myositis 10.0
14 mccune-albright syndrome 10.0
15 chondrosarcoma 10.0
16 myositis ossificans 10.0
17 pseudosarcomatous fibromatosis 10.0
18 exophthalmos 10.0
19 fasciitis 10.0
20 juvenile ossifying fibroma 10.0
21 polyarticular onset juvenile idiopathic arthritis 10.0 TNFRSF11A TNFSF11
22 breast leiomyosarcoma 10.0 TNFRSF11A TNFSF11
23 hemophilic arthropathy 10.0 TNFRSF11A TNFSF11
24 osteopetrosis, autosomal recessive 7 10.0 TNFRSF11A TNFSF11
25 familial expansile osteolysis 10.0 TNFRSF11A TNFSF11
26 multicentric carpotarsal osteolysis syndrome 10.0 TNFRSF11A TNFSF11
27 osteopetrosis, autosomal recessive 2 10.0 TNFRSF11A TNFSF11
28 periapical periodontitis 10.0 TNFRSF11A TNFSF11
29 cherubism 9.9
30 hydrocephalus 9.9
31 scoliosis 9.9
32 alzheimer disease 2 9.9 GSK3B MAPT
33 glucocorticoid-induced osteoporosis 9.9 CALCA TNFSF11
34 paget disease of bone 5, juvenile-onset 9.8 CALCA TNFRSF11A TNFSF11
35 root resorption 9.8 CALCA TNFRSF11A TNFSF11
36 bone resorption disease 9.8 CALCA TNFRSF11A TNFSF11
37 bone remodeling disease 9.8 CALCA TNFRSF11A TNFSF11
38 paget's disease of bone 9.8 CALCA TNFRSF11A TNFSF11
39 renal cell carcinoma, nonpapillary 9.8
40 cyclic neutropenia 9.8
41 celiac disease 1 9.8
42 chordoma 9.8
43 osteogenic sarcoma 9.8
44 insulin-like growth factor i 9.8
45 focal dermal hypoplasia 9.8
46 brittle bone disorder 9.8
47 langerhans cell histiocytosis 9.8
48 gastrointestinal stromal tumor 9.8
49 osteofibrous dysplasia 9.8
50 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 1, Phase 2,Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 1, Phase 2,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2
3 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

41
Bone, Endothelial, Bone Marrow, Breast, Spinal Cord, Kidney, Lymph Node
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 1048)
# Title Authors Year
1
Bisphosphonate therapy for spinal aneurysmal bone cysts. ( 29356986 )
2018
2
CT-guided radiofrequency ablation in patients with aneurysmal bone cysts. ( 29496068 )
2018
3
Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts. ( 29987657 )
2018
4
Treatment of aneurysmal bone cysts using endoscopic curettage. ( 30053808 )
2018
5
Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results. ( 30086700 )
2018
6
Fluid-Fluid Levels in Aneurysmal Bone Cysts. ( 30270163 )
2018
7
Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine. ( 30470879 )
2018
8
A case of dedifferentiated chondrosarcoma arising in the cricoid cartilage that mimicked an aneurysmal bone cyst. ( 29160138 )
2018
9
Concomittant fibrous dysplasia with aneurysmal bone cyst formation within the skull, humerus and rib. ( 30057744 )
2018
10
Secondary Aneurysmal Bone Cyst in a Craniofacial Fibrous Dysplasia: Case Report. ( 30381923 )
2018
11
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. ( 29489506 )
2018
12
Recurrent juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of the maxilla: a case report and review of literature. ( 30090219 )
2018
13
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. ( 29892520 )
2018
14
Central Giant Cell Granuloma with Aneurysmal Bone Cyst in a 28-Year Male Patient: A Rare Concurrence. ( 29866246 )
2018
15
Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components. ( 30392920 )
2018
16
Aneurysmal bone cyst healing response with intramedullary lengthening nail. ( 28529010 )
2018
17
Aggressive development of an aneurysmal bone cyst of the proximal femur in a paediatric patient: a case report. ( 28835150 )
2018
18
Surgical treatment of a lumbar aneurysmal bone cyst using percutaneous endoscopic lumbar discectomy. ( 28942467 )
2018
19
Denosumab treatment in aneurysmal bone cyst: Evaluation of nine cases. ( 29286564 )
2018
20
Aneurysmal Bone Cyst of Mandible with Classical Histopathological Presentation. ( 29394987 )
2018
21
Paediatric aneurysmal bone cyst: not as easy as ABC. ( 29423170 )
2018
22
Solid Variant of Aneurysmal Bone Cyst of the Temporal Bone. ( 29436237 )
2018
23
Denosumab: a potential treatment option for aneurysmal bone cyst of the atlas. ( 29470716 )
2018
24
Treatment of the aneurysmal bone cyst by percutaneous intracystic sclerotherapy using ethanol ninety five percent in children. ( 29492610 )
2018
25
Do multiple fluid-fluid levels on MRI always reveal primary benign aneurysmal bone cyst? ( 29540050 )
2018
26
Comments on treatment of the aneurysmal bone cyst by percutaneous intracystic sclerotherapy using ethanol ninety five percent in children. ( 29556694 )
2018
27
Periosteal aneurysmal bone cyst. ( 29611530 )
2018
28
Early Recurrence of a Solid Variant of Aneurysmal Bone Cyst in a Young Child After Resection: Technique and Literature Review and Two-year Follow-up After Corpectomy. ( 29642082 )
2018
29
Expert's comment concerning Grand Rounds case entitled "Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization" by S. Rajasekaran et al. (Eur Spine J; 2016: DOI 10.1007/s00586-016-4518-0). ( 29687181 )
2018
30
Mandibular aneurysmal bone cyst in an elderly patient: Case report. ( 29733532 )
2018
31
Hindfoot aneurysmal bone cyst: report of two cases. ( 29911096 )
2018
32
Review of 16 cases of aneurysmal bone cyst in the proximal femur treated by extended curettage and cryosurgery with reconstruction using autogenous nonvascularized fibula graft. ( 29954245 )
2018
33
Metacarpal Aneurysmal Bone Cyst En Bloc Resection Reconstructed With Osteoarticular Allograft. ( 30017650 )
2018
34
Solid aneurysmal bone cyst of the humerus mimics metastasis or brown tumor. ( 30056289 )
2018
35
Aneurysmal Bone Cyst of the Maxillary Sinus with USP6 Rearrangement: Case Report of a Rare Entity and Review of the Literature. ( 30076509 )
2018
36
Spheno-Orbital Aneurysmal Bone Cyst in a 10-Month-Old Infant. ( 30157596 )
2018
37
Aneurysmal Bone Cyst of 3rd Metacarpal, Management and Follow-up: A Case Report. ( 30167402 )
2018
38
Aneurysmal bone cyst of the clavicle: a series of 13 cases. ( 30243904 )
2018
39
Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. ( 30401581 )
2018
40
Complete resolution of a cervical spine aneurysmal bone cyst after single session of endovascular embolization: Case report. ( 30409051 )
2018
41
Atypical presentation of a solid-variant orbital aneurysmal bone cyst with a literature review. ( 30413280 )
2018
42
PERCUTANEOUS TREATMENT OF ANEURYSMAL BONE CYST WITH CALCITONIN AND METHYLPREDNISOLONE. ( 30464712 )
2018
43
Massive aneurysmal bone cyst of the skull base treated with denosumab. ( 30475414 )
2018
44
Adjuvant MRI-guided percutaneous cryoablation treatment for aneurysmal bone cyst. ( 30523379 )
2018
45
Primary aneurysmal bone cyst with a novel SPARC-USP6 translocation identified by next-generation sequencing. ( 30553465 )
2018
46
Aneurysmal bone cysts and pathologic fracture associated with supernumerary ring chromosome 6 in two unrelated patients. ( 29080333 )
2017
47
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. ( 28454393 )
2017
48
Cervical Spine Aneurysmal Bone Cysts in the Pediatric Population: A Systematic Review of the Literature. ( 28605734 )
2017
49
Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing. ( 28449806 )
2017
50
Sclerotherapy using Surgiflo and alcohol: a new alternative for the treatment of aneurysmal bone cysts. ( 29263757 )
2017

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
3 axon GO:0030424 9.26 CALCA CDK5 GSK3B MAPT

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.75 CALCA MAPT TNFRSF11A
2 neuron projection development GO:0031175 9.7 CDK5 GSK3B MAPT
3 ossification GO:0001503 9.58 CDH11 TNFRSF11A TNFSF11
4 cellular response to nerve growth factor stimulus GO:1990090 9.57 CALCA MAPT
5 regulation of microtubule cytoskeleton organization GO:0070507 9.56 GSK3B MAPT
6 cellular response to amyloid-beta GO:1904646 9.55 CDK5 GSK3B
7 osteoclast differentiation GO:0030316 9.54 TNFRSF11A TNFSF11
8 positive regulation of bone resorption GO:0045780 9.51 TNFRSF11A TNFSF11
9 monocyte chemotaxis GO:0002548 9.5 CALCA TNFRSF11A TNFSF11
10 mammary gland alveolus development GO:0060749 9.49 TNFRSF11A TNFSF11
11 regulation of protein localization to plasma membrane GO:1903076 9.48 CDK5 GBP1
12 central nervous system neuron development GO:0021954 9.46 CDK5 MAPT
13 regulation of calcium-mediated signaling GO:0050848 9.43 GBP1 MAPT
14 positive regulation of neuron death GO:1901216 9.43 CDK5 GSK3B MAPT
15 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFRSF11A TNFSF11
16 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
17 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
18 sodium-independent organic anion transport GO:0043252 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.32 GBP1 TNFRSF11A
2 tau-protein kinase activity GO:0050321 9.26 CDK5 GSK3B
3 dynactin binding GO:0034452 9.16 GSK3B MAPT
4 Hsp90 protein binding GO:0051879 9.13 CDK5 GBP1 MAPT
5 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....