MCID: ANR009
MIFTS: 46

Aneurysmal Bone Cysts

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 57 38 53 13
Aneurysmal Bone Cyst 59 29
Bone Cysts, Aneurysmal 73
Bone Cysts Aneurysmal 55

Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

OMIM 57 606179
Orphanet 59 ORPHA480553
MedGen 42 C0152244
ICD10 33 M85.5
UMLS 73 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to giant cell tumor and giant cell reparative granuloma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 76 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.0 CALCA TNFRSF11A TNFSF11
2 giant cell reparative granuloma 30.0 CALCA TNFRSF11A USP6
3 tooth resorption 29.7 TNFRSF11A TNFSF11
4 aneurysm 11.0
5 chondroblastoma 10.4
6 polyarticular onset juvenile idiopathic arthritis 10.3 TNFRSF11A TNFSF11
7 fibrous dysplasia 10.3
8 breast leiomyosarcoma 10.3 TNFRSF11A TNFSF11
9 hemophilic arthropathy 10.3 TNFRSF11A TNFSF11
10 familial expansile osteolysis 10.2 TNFRSF11A TNFSF11
11 osteoblastoma 10.2
12 multicentric carpotarsal osteolysis syndrome 10.2 TNFRSF11A TNFSF11
13 ossifying fibroma 10.2
14 periapical periodontitis 10.2 TNFRSF11A TNFSF11
15 cervicitis 10.2
16 myositis 9.9
17 myositis ossificans 9.9
18 juvenile ossifying fibroma 9.9
19 chondromyxoid fibroma 9.9
20 ischemic bone disease 9.9 TNFRSF11A TNFSF11
21 glucocorticoid-induced osteoporosis 9.8 CALCA TNFSF11
22 cherubism 9.8
23 mccune-albright syndrome 9.8
24 chondrosarcoma 9.8
25 ameloblastoma 9.8
26 bone giant cell tumor 9.8
27 pseudosarcomatous fibromatosis 9.8
28 fasciitis 9.8
29 paget disease of bone 5, juvenile-onset 9.8 CALCA TNFRSF11A TNFSF11
30 root resorption 9.8 CALCA TNFRSF11A TNFSF11
31 bone resorption disease 9.7 CALCA TNFRSF11A TNFSF11
32 bone remodeling disease 9.7 CALCA TNFRSF11A TNFSF11
33 paget's disease of bone 9.7 CALCA TNFRSF11A TNFSF11
34 osteoid osteoma 9.7
35 focal dermal hypoplasia 9.7
36 langerhans cell histiocytosis 9.7
37 gastrointestinal stromal tumor 9.7
38 osteofibrous dysplasia 9.7
39 bone fracture 9.7
40 hydrocephalus 9.7
41 sinusitis 9.7
42 angiosarcoma 9.7
43 partial third-nerve palsy 9.7
44 horner's syndrome 9.7
45 secondary hyperparathyroidism of renal origin 9.7
46 hyperparathyroidism 9.7
47 obstructive hydrocephalus 9.7
48 optic nerve disease 9.7
49 chondroma 9.7
50 thoracic outlet syndrome 9.7

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 1, Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

41
Bone, Endothelial, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 400)
# Title Authors Year
1
Myositis ossificans - Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. ( 29661729 )
2018
2
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting with Hemothorax in a Child: Erratum. ( 29738344 )
2018
3
Bisphosphonate therapy for spinal aneurysmal bone cysts. ( 29356986 )
2018
4
CT-guided radiofrequency ablation in patients with aneurysmal bone cysts. ( 29496068 )
2018
5
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
6
Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report. ( 27853880 )
2017
7
Use of Intraoperative Navigation for Reconstruction of the C1 Lateral Mass After Resection of Aneurysmal Bone Cyst. ( 28408261 )
2017
8
[Primary aneurysmal bone cyst of the maxillary sinus]. ( 28473025 )
2017
9
Aneurysmal bone cysts and pathologic fracture associated with supernumerary ring chromosome 6 in two unrelated patients. ( 29080333 )
2017
10
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2017
11
Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst-Like Morphology. ( 28193096 )
2017
12
Diagnosing and discriminating between primary and secondary aneurysmal bone cysts. ( 28454393 )
2017
13
Solid Variant of Aneurysmal Bone Cyst Masquerading as Malignancy. ( 28892920 )
2017
14
Cervical Spine Aneurysmal Bone Cysts in the Pediatric Population: A Systematic Review of the Literature. ( 28605734 )
2017
15
An Unusual Radiographic Presentation of Aneurysmal Bone Cyst of the Zygoma: A Rare Case Report. ( 28658921 )
2017
16
Recurrent Psammomatoid Juvenile Ossifying Fibroma with Aneurysmal Bone Cyst: An Unusual Case Presentation. ( 29184270 )
2017
17
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting With Hemothorax in a Child. ( 28859035 )
2017
18
Solid variant aneurysmal bone cyst in the distal fibular metaphysis: radiologic and pathologic challenges to diagnosis. ( 28828126 )
2017
19
Secondary aneurysmal bone cyst in McCune-Albright syndrome. ( 29354163 )
2017
20
An Aneurysmal Bone Cyst in the Skull Base. ( 28872506 )
2017
21
Gene fusions PAFAH1B1-USP6 and RUNX2-USP6 in aneurysmal bone cysts identified by next generation sequencing. ( 28449806 )
2017
22
Can ethanol be used as an adjuvant to extended curettage in order to reduce the recurrence rate of aneurysmal bone cyst? ( 28702396 )
2017
23
Sclerotherapy using Surgiflo and alcohol: a new alternative for the treatment of aneurysmal bone cysts. ( 29263757 )
2017
24
Treatment of Aneurysmal Bone Cysts with Bioactive Glass in Children. ( 28950789 )
2017
25
Extraskeletal aneurysmal bone cyst: Report of a case and review of the literature. ( 28756986 )
2017
26
USP6 gene rearrangement differentiate primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions, report of a rare case. ( 29217425 )
2017
27
Treatment of aneurysmal bone cysts by percutaneous CT-guided injection of calcitonin and steroid. ( 27743037 )
2017
28
Selective arterial Embolisation of Aneurysmal Bone Cysts ofA the Sacrum: a promising Alternative to Surgery. ( 26695847 )
2016
29
Giant Cell Tumor with Secondary Aneurysmal Bone Cyst Shows Heterogeneous Metabolic Pattern on (18)F-FDG PET/CT: A Case Report. ( 27994691 )
2016
30
Secondary Aneurysmal Bone Cyst of the Scapula Treated by CT Guided Percutaneous Polidocanol Injection - A Case Report. ( 28208959 )
2016
31
Aneurysmal Bone Cyst Arising from the First Rib: A Rare Cause of Thoracic Outlet Syndrome. ( 28018833 )
2016
32
Temporal aneurysmal bone cyst: cost-effective method to achieve gross total resection. ( 27334736 )
2016
33
Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe. ( 28435549 )
2016
34
Radiotherapy for aneurysmal bone cysts : AA rare indication. ( 27957589 )
2016
35
How effective is embolization with N-2-butyl-cyanoacrylate for aneurysmal bone cysts? ( 27933423 )
2016
36
Aneurysmal bone cyst of the mandible affecting the articular condyle: a case report. ( 27980757 )
2016
37
Aneurysmal Bone Cyst: An Uncommon Secondary Event in Calcaneal Chondroblastoma. ( 27504302 )
2016
38
Conversion of Aneurysmal Bone Cyst into Fibrous Dysplasia: A Rare Pediatric Case Report. ( 27408470 )
2016
39
Current management of aneurysmal bone cysts. ( 27778155 )
2016
40
Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome. ( 27161212 )
2016
41
Unicameral (simple) and aneurysmal bone cysts: the effect of insufficient curettage on recurrence. ( 28154666 )
2016
42
Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report. ( 26893764 )
2016
43
Interest of Denosumab for the Treatment of Giant-cells Tumors and Aneurysmal Bone Cysts of the Spine. About Nine Cases. ( 27244112 )
2016
44
Treatment outcome in 60 children with pathological fractures of the humerus caused by juvenile or aneurysmal bone cysts. ( 29182112 )
2016
45
A case report of granular cell ameloblastoma associated with aneurysmal bone cyst like features. ( 26538973 )
2015
46
A rare case of osteoblastoma associated to aneurysmal bone cyst of the spine. Case report. ( 26204456 )
2015
47
Percutaneous Doxycycline Treatment of Juxtaphyseal Aneurysmal Bone Cysts. ( 25985367 )
2015
48
Psammous desmo-osteoblastoma with concomitant aneurysmal bone cyst of mandible. ( 26389053 )
2015
49
Current Strategies for the Treatment of Aneurysmal Bone Cysts. ( 26793296 )
2015
50
Unusual localizations of unicameral bone cysts and aneurysmal bone cysts: A retrospective review of 451 cases. ( 26280957 )
2015

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
3 axon GO:0030424 9.26 CALCA CDK5 GSK3B MAPT

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.61 CDH11 TNFRSF11A TNFSF11
2 cellular response to nerve growth factor stimulus GO:1990090 9.57 CALCA MAPT
3 osteoclast differentiation GO:0030316 9.56 TNFRSF11A TNFSF11
4 neuron projection development GO:0031175 9.56 CDH11 CDK5 GSK3B MAPT
5 cellular response to amyloid-beta GO:1904646 9.55 CDK5 GSK3B
6 regulation of microtubule cytoskeleton organization GO:0070507 9.54 GSK3B MAPT
7 monocyte chemotaxis GO:0002548 9.54 CALCA TNFRSF11A TNFSF11
8 positive regulation of bone resorption GO:0045780 9.52 TNFRSF11A TNFSF11
9 mammary gland alveolus development GO:0060749 9.51 TNFRSF11A TNFSF11
10 sodium-independent organic anion transport GO:0043252 9.5 SLCO1A2 SLCO3A1 SLCO4A1
11 central nervous system neuron development GO:0021954 9.49 CDK5 MAPT
12 regulation of protein localization to plasma membrane GO:1903076 9.48 CDK5 GBP1
13 regulation of calcium-mediated signaling GO:0050848 9.46 GBP1 MAPT
14 TNFSF11-mediated signaling pathway GO:0071847 9.4 TNFRSF11A TNFSF11
15 positive regulation of neuron death GO:1901216 9.33 CDK5 GSK3B MAPT
16 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
17 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.32 GBP1 TNFRSF11A
2 tau-protein kinase activity GO:0050321 9.26 CDK5 GSK3B
3 dynactin binding GO:0034452 9.16 GSK3B MAPT
4 Hsp90 protein binding GO:0051879 9.13 CDK5 GBP1 MAPT
5 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....