MCID: ANR009
MIFTS: 45

Aneurysmal Bone Cysts

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 57 53 13 38
Aneurysmal Bone Cyst 59 29 17 33
Bone Cysts, Aneurysmal 72
Bone Cysts Aneurysmal 55

Classifications:

Orphanet: 59  
Rare bone diseases


External Ids:

OMIM 57 606179
ICD10 33 M85.5
Orphanet 59 ORPHA480553
MedGen 42 C0152244
UMLS 72 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to giant cell reparative granuloma and giant cell tumor, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 75 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

More information from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 giant cell reparative granuloma 30.4 USP6 TNFRSF11A CALCA
2 giant cell tumor 30.4 TNFSF11 TNFRSF11A CALCA
3 bone giant cell tumor 30.2 TNFSF11 CALCA
4 tooth resorption 29.6 TNFSF11 TNFRSF11A
5 root resorption 29.0 TNFSF11 TNFRSF11A CALCA
6 bone resorption disease 29.0 TNFSF11 TNFRSF11A CALCA
7 paget's disease of bone 28.9 TNFSF11 TNFRSF11A CALCA
8 bone disease 28.9 TNFSF11 TNFRSF11A CALCA
9 fibrous dysplasia 10.8
10 osteogenic sarcoma 10.7
11 fibroma 10.6
12 chondroblastoma 10.6
13 osteoblastoma 10.6
14 ossifying fibroma 10.5
15 exophthalmos 10.5
16 telangiectatic osteogenic sarcoma 10.4
17 back pain 10.4
18 paraplegia 10.3
19 myositis 10.3
20 myositis ossificans 10.3
21 chondromyxoid fibroma 10.3
22 solitary bone cyst 10.3
23 hyperparathyroidism 10.3
24 chondrosarcoma 10.2
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
26 hemangioma 10.2
27 fasciitis 10.2
28 headache 10.2
29 mccune-albright syndrome 10.2
30 scoliosis 10.2
31 chondroma 10.2
32 radiculopathy 10.2
33 pseudosarcomatous fibromatosis 10.2
34 juvenile ossifying fibroma 10.2
35 rare tumor 10.2
36 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
37 histiocytoma 10.1
38 fibrous histiocytoma 10.1
39 paresthesia 10.1
40 eosinophilic granuloma 10.1
41 torticollis 10.1
42 ameloblastoma 10.1
43 hydrocephalus 10.1
44 horner's syndrome 10.1
45 facial paralysis 10.1
46 fibrosarcomatous osteosarcoma 10.1
47 intracranial hypertension 10.1
48 congenital hydrocephalus 10.1
49 enchondroma 10.1
50 head injury 10.1

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts Recruiting NCT03066245 Phase 1, Phase 2
3 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

41
Bone, Endothelial, Bone Marrow, Spinal Cord, Lung, Testes, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 2113)
# Title Authors PMID Year
1
Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts. 38 8
11408073 2001
2
Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. 38 8
10502326 1999
3
Aneurysmal bone cysts. A clinicopathologic study of 66 cases. 38 8
5458269 1970
4
Percutaneous intralesional injection of calcitonin and methylprednisolone for treatment of an aneurysmal bone cyst at C-2. 9 38
18976109 2008
5
Aneurysmal bone cyst at C2: imaging evaluation after intralesional injection of calcitonin and methylprednisolone. 9 38
18949268 2008
6
[Aneurysmal bone cyst of the cranial base treated by partial resection and calcitonin injection. A case report]. 9 38
16609661 2006
7
Aneurysmal bone cyst of the first cervical vertebrae in a child treated with percutaneous intralesional injection of calcitonin and methylprednisolone. A case report. 9 38
10707403 2000
8
Sciatica secondary to an aneurysmal bone cyst treated with in situ calcitonin injections. 9 38
9385701 1997
9
Calcitonin therapy of aneurysmal bone cysts. 9 38
1400569 1992
10
Aneurysmal Bone Cyst of the Maxillary Sinus with USP6 Rearrangement: Case Report of a Rare Entity and Review of the Literature. 38
30076509 2019
11
Giant cell tumors combined with secondary aneurysmal bone cysts are more likely to develop postoperative recurrence: A retrospective study of 256 cases. 38
31219620 2019
12
RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst. 38
30767316 2019
13
Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histologic features and skeletal distribution. 38
31429985 2019
14
Aneurysmal Bone Cyst in a Renal Transplant Patient. 38
31324137 2019
15
Adjuvant MRI-guided percutaneous cryoablation treatment for aneurysmal bone cyst. 38
30523379 2019
16
Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. 38
30844887 2019
17
Some Alternative Treatments for Aneurysmal Bone Cysts. 38
31266113 2019
18
Denosumab for treating aneurysmal bone cysts in children. 38
31358461 2019
19
In Reply to "Some Alternative Treatments for Aneurysmal Bone Cysts". 38
31266114 2019
20
Thrombosed Middle Meningeal Artery Aneurysms Mimicking Aneurysmal Bone Cysts in a Patient with Fibrous Dysplasia. 38
31306839 2019
21
Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature. 38
30603771 2019
22
Differing characteristics of cartilaginous lesions of the larynx. 38
31338576 2019
23
Juvenile ossifying fibroma of the jaws and paranasal sinuses: a systematic review of the cases reported in the literature. 38
31285096 2019
24
A rare case of recurrent vascular aneurysmal bone cyst of the orbit in a 4-year-old child. 38
31361255 2019
25
Intraosseous ganglion diagnosed on cytology: A familiar entity in an exotic location. 38
31359500 2019
26
Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine. 38
30470879 2019
27
Symptomatic aneurysmal bone cysts of the spine: clinical features, surgical outcomes, and prognostic factors. 38
30838451 2019
28
Aneurysmal Bone Cyst of the Distal Femoral Metaphysis in a Four-year-old Female Patient Presenting with a Pathologic Fracture: A Case Report. 38
31410329 2019
29
Complete resolution of a cervical spine aneurysmal bone cyst after single session of endovascular embolization: Case report. 38
30409051 2019
30
Aneurysmal bone cyst of the mandible with conservative surgical management: A case report. 38
31346378 2019
31
Cutaneous aneurysmal bone cyst-First report of a case and literature review. 38
31206756 2019
32
Common conditions associated with displacement of the inferior alveolar nerve canal: A radiographic diagnostic aid. 38
31281784 2019
33
Induced membrane technique for clavicle reconstruction in paediatric patients: Report of four cases. 38
31088774 2019
34
Metacarpal Aneurysmal Bone Cyst En Bloc Resection Reconstructed With Osteoarticular Allograft. 38
30017650 2019
35
Multidisciplinary management of spinal aneurysmal bone cysts: A single-center experience. 38
31088242 2019
36
Computed tomography-based navigation system-assisted surgery for primary spine tumor. 38
30827883 2019
37
An aneurysmal bone cyst at T1 treated with bone grafts containing calcitonin and methylprednisolone. 38
30943849 2019
38
Chondroblastoma-like mass of the temporal bone, secondary aneurysmal bone cyst, and intracerebral hemorrhage in a patient with cardiofaciocutaneous syndrome: case report. 38
31125963 2019
39
A large aneurysmal bone cyst of the rib. 38
30798612 2019
40
Aneurysmal bone cyst treated with percutaneous doxycycline: is a single treatment sufficient? 38
30809704 2019
41
Examination and Management of a 4-Year-Old Following a Femoral Aneurysmal Bone Cyst: A Case Report. 38
30907844 2019
42
Aneurysmal bone cysts of the clavicle: a comparison of extended curettage and segmental resection with bone reconstruction. 38
31028011 2019
43
Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology. 38
31321219 2019
44
Aneurysmal Bone Cyst after Femoral Derotational Osteotomy: A Case Report. 38
31001384 2019
45
Severe life-threatening hypersensitivity reaction to polidocanol in a case of recurrent aneurysmal bone cyst. 38
30828217 2019
46
Multimodal management of an aggressive recurrent aneurysmal bone cyst of the spine: Case report and review of the literature. 38
30904804 2019
47
Fibrous dysplasia with secondary aneurysmal bone cyst-a rare case report and literature review. 38
30758737 2019
48
Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. 38
30401581 2019
49
Aneursymal Bone Cyst: An Uncommon Paraspinal Tumor in Children. 38
29901559 2019
50
Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization. 38
27007865 2019

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
2 plasma membrane GO:0005886 9.36 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
3 axon GO:0030424 9.13 MAPT GSK3B CDK5

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.75 TNFRSF11A MAPT CALCA
2 neuron projection development GO:0031175 9.7 MAPT GSK3B CDK5
3 ossification GO:0001503 9.58 TNFSF11 TNFRSF11A CDH11
4 regulation of microtubule cytoskeleton organization GO:0070507 9.56 MAPT GSK3B
5 osteoclast differentiation GO:0030316 9.55 TNFSF11 TNFRSF11A
6 cellular response to amyloid-beta GO:1904646 9.54 GSK3B CDK5
7 positive regulation of bone resorption GO:0045780 9.51 TNFSF11 TNFRSF11A
8 monocyte chemotaxis GO:0002548 9.5 TNFSF11 TNFRSF11A CALCA
9 mammary gland alveolus development GO:0060749 9.49 TNFSF11 TNFRSF11A
10 regulation of protein localization to plasma membrane GO:1903076 9.48 GBP1 CDK5
11 central nervous system neuron development GO:0021954 9.46 MAPT CDK5
12 regulation of calcium-mediated signaling GO:0050848 9.43 MAPT GBP1
13 positive regulation of neuron death GO:1901216 9.43 MAPT GSK3B CDK5
14 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFSF11 TNFRSF11A
15 cellular response to nerve growth factor stimulus GO:1990090 9.27 MAPT
16 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.16 TNFSF11 TNFRSF11A
17 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFSF11 TNFRSF11A
18 sodium-independent organic anion transport GO:0043252 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.32 TNFRSF11A GBP1
2 tau-protein kinase activity GO:0050321 9.26 GSK3B CDK5
3 dynactin binding GO:0034452 9.16 MAPT GSK3B
4 Hsp90 protein binding GO:0051879 9.13 MAPT GBP1 CDK5
5 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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