MCID: ANR009
MIFTS: 48

Aneurysmal Bone Cysts

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 58 39 54 13
Aneurysmal Bone Cyst 60 30 17
Bone Cysts, Aneurysmal 74
Bone Cysts Aneurysmal 56

Classifications:

Orphanet: 60  
Rare bone diseases


External Ids:

OMIM 58 606179
ICD10 34 M85.5
Orphanet 60 ORPHA480553
MedGen 43 C0152244
UMLS 74 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to giant cell tumor and giant cell reparative granuloma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial.

Wikipedia : 77 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

Description from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.3 CALCA TNFRSF11A TNFSF11
2 giant cell reparative granuloma 30.2 CALCA TNFRSF11A USP6
3 bone giant cell tumor 30.1 CALCA TNFSF11
4 tooth resorption 29.5 TNFRSF11A TNFSF11
5 fibrous dysplasia 10.6
6 chondroblastoma 10.5
7 fibroma 10.5
8 osteoblastoma 10.4
9 ossifying fibroma 10.4
10 degos 'en cocarde' erythrokeratoderma 10.3
11 telangiectatic osteogenic sarcoma 10.2
12 chondromyxoid fibroma 10.2
13 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
14 paraplegia 10.1
15 myositis 10.1
16 mccune-albright syndrome 10.1
17 chondrosarcoma 10.1
18 myositis ossificans 10.1
19 pseudosarcomatous fibromatosis 10.1
20 exophthalmos 10.1
21 fasciitis 10.1
22 juvenile ossifying fibroma 10.1
23 alzheimer disease 2 10.0 GSK3B MAPT
24 polyarticular onset juvenile idiopathic arthritis 10.0 TNFRSF11A TNFSF11
25 cherubism 10.0
26 osteogenic sarcoma 10.0
27 langerhans cell histiocytosis 10.0
28 hydrocephalus 10.0
29 scoliosis 10.0
30 histiocytosis 10.0
31 congenital hydrocephalus 10.0
32 hemophilic arthropathy 10.0 TNFRSF11A TNFSF11
33 osteopetrosis, autosomal recessive 7 9.9 TNFRSF11A TNFSF11
34 breast leiomyosarcoma 9.9 TNFRSF11A TNFSF11
35 familial expansile osteolysis 9.9 TNFRSF11A TNFSF11
36 multicentric carpotarsal osteolysis syndrome 9.9 TNFRSF11A TNFSF11
37 osteopetrosis, autosomal recessive 2 9.9 TNFRSF11A TNFSF11
38 periapical periodontitis 9.9 TNFRSF11A TNFSF11
39 glucocorticoid-induced osteoporosis 9.8 CALCA TNFSF11
40 renal cell carcinoma, nonpapillary 9.8
41 cyclic neutropenia 9.8
42 celiac disease 1 9.8
43 chordoma 9.8
44 insulin-like growth factor i 9.8
45 focal dermal hypoplasia 9.8
46 yemenite deaf-blind hypopigmentation syndrome 9.8
47 brittle bone disorder 9.8
48 gastrointestinal stromal tumor 9.8
49 osteofibrous dysplasia 9.8
50 hemorrhage, intracerebral 9.8

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 1, Phase 2,Phase 2 615258-40-7
2 Bone Density Conservation Agents Phase 1, Phase 2,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC) Recruiting NCT03066245 Phase 1, Phase 2
3 Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 30

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

42
Bone, Endothelial, Bone Marrow, Breast, Spinal Cord, Kidney, Lymph Node
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 1241)
# Title Authors Year
1
Multidisciplinary management of spinal aneurysmal bone cysts: A single-center experience. ( 31088242 )
2019
2
Aneurysmal bone cysts of the clavicle: a comparison of extended curettage and segmental resection with bone reconstruction. ( 31028011 )
2019
3
Denosumab Therapy in the Management of Aneurysmal Bone Cysts: A Comprehensive Literature Review. ( 30972268 )
2019
4
Symptomatic aneurysmal bone cysts of the spine: clinical features, surgical outcomes, and prognostic factors. ( 30838451 )
2019
5
Percutaneous Doxycycline Foam Injections, A Novel Treatment Method for Vertebral Aneurysmal Bone Cysts. ( 30710721 )
2019
6
Understanding Unicameral and Aneurysmal Bone Cysts. ( 30709971 )
2019
7
Fluid-Fluid Levels in Aneurysmal Bone Cysts. ( 30270163 )
2019
8
Fibrous dysplasia with secondary aneurysmal bone cyst-a rare case report and literature review. ( 30758737 )
2019
9
Secondary aneurysmal bone cyst in Langerhans cell histiocytosis: Case report, literature review. ( 30809556 )
2019
10
Cervical Spine Osteoblastoma with an Aneurysmal Bone Cyst in a 2-Year-Old Child: A Case Report. ( 30673670 )
2019
11
Severe life-threatening hypersensitivity reaction to polidocanol in a case of recurrent aneurysmal bone cyst. ( 30828217 )
2019
12
Metacarpal Aneurysmal Bone Cyst En Bloc Resection Reconstructed With Osteoarticular Allograft. ( 30017650 )
2019
13
Aneurysmal bone cyst of the clavicle: a series of 13 cases. ( 30243904 )
2019
14
Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components. ( 30392920 )
2019
15
Primary aneurysmal bone cyst of the mandibular condyle with USP6-CDH11 fusion. ( 30401581 )
2019
16
Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature. ( 30603771 )
2019
17
Aneurysmal bone cyst of C2 treated with novel anterior reconstruction and stabilization. ( 27007865 )
2019
18
Aneurysmal Bone Cyst after Femoral Derotational Osteotomy: A Case Report. ( 31001384 )
2019
19
An aneurysmal bone cyst at T1 treated with bone grafts containing calcitonin and methylprednisolone. ( 30943849 )
2019
20
Denosumab: A potential new treatment option for recurrent Aneurysmal Bone Cyst of the spine. ( 30931897 )
2019
21
Examination and Management of a 4-Year-Old Following a Femoral Aneurysmal Bone Cyst: A Case Report. ( 30907844 )
2019
22
Multimodal management of an aggressive recurrent aneurysmal bone cyst of the spine: Case report and review of the literature. ( 30904804 )
2019
23
Aneurysmal bone cyst treated with percutaneous doxycycline: is a single treatment sufficient? ( 30809704 )
2019
24
A large aneurysmal bone cyst of the rib. ( 30798612 )
2019
25
RNA sequencing identifies a novel USP9X-USP6 promoter swap gene fusion in a primary aneurysmal bone cyst. ( 30767316 )
2019
26
Aneurysmal Bone Cyst-An Unusual Presentation of Wrist Pain. ( 30723607 )
2019
27
Percutaneous albumin/doxycycline injection versus open surgery for aneurysmal bone cysts in the mobile spine. ( 30470879 )
2018
28
Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results. ( 30086700 )
2018
29
Treatment of aneurysmal bone cysts using endoscopic curettage. ( 30053808 )
2018
30
Characterization of doxycycline-loaded calcium phosphate cement: implications for treatment of aneurysmal bone cysts. ( 29987657 )
2018
31
CT-guided radiofrequency ablation in patients with aneurysmal bone cysts. ( 29496068 )
2018
32
Bisphosphonate therapy for spinal aneurysmal bone cysts. ( 29356986 )
2018
33
Treatment of Aneurysmal Bone Cysts with Bioactive Glass in Children. ( 28950789 )
2018
34
Periosteal chondroma of the cuboid with secondary aneurysmal bone cyst in a setting of secondary hyperparathyroidism. ( 29413778 )
2018
35
A case of dedifferentiated chondrosarcoma arising in the cricoid cartilage that mimicked an aneurysmal bone cyst. ( 29160138 )
2018
36
Myositis ossificans - Another condition with USP6 rearrangement, providing evidence of a relationship with nodular fasciitis and aneurysmal bone cyst. ( 29661729 )
2018
37
Conservative management of an atypical intra-sinusal ossifying fibroma associated to an aneurysmal bone cyst. ( 29074442 )
2018
38
Recurrent juvenile psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of the maxilla: a case report and review of literature. ( 30090219 )
2018
39
Concomittant fibrous dysplasia with aneurysmal bone cyst formation within the skull, humerus and rib. ( 30057744 )
2018
40
Secondary Aneurysmal Bone Cyst in a Craniofacial Fibrous Dysplasia: Case Report. ( 30381923 )
2018
41
Chondromyxoid fibroma with a secondary aneurysmal bone cyst of the distal radius: A case report. ( 30580890 )
2018
42
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting with Hemothorax in a Child: Erratum. ( 29738344 )
2018
43
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. ( 29489506 )
2018
44
Telangiectatic osteosarcoma: Outcome analyses and a diagnostic model for differentiation from aneurysmal bone cyst. ( 29892520 )
2018
45
Central Giant Cell Granuloma with Aneurysmal Bone Cyst in a 28-Year Male Patient: A Rare Concurrence. ( 29866246 )
2018
46
Aneurysmal bone cyst healing response with intramedullary lengthening nail. ( 28529010 )
2018
47
Aggressive development of an aneurysmal bone cyst of the proximal femur in a paediatric patient: a case report. ( 28835150 )
2018
48
Surgical treatment of a lumbar aneurysmal bone cyst using percutaneous endoscopic lumbar discectomy. ( 28942467 )
2018
49
USP6 gene rearrangement differentiates primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions: report of a rare case. ( 29217425 )
2018
50
Denosumab treatment in aneurysmal bone cyst: Evaluation of nine cases. ( 29286564 )
2018

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
2 plasma membrane GO:0005886 9.36 CDH11 CDK5 GBP1 GSK3B MAPT SLCO1A2
3 axon GO:0030424 9.13 CDK5 GSK3B MAPT

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.75 CALCA MAPT TNFRSF11A
2 neuron projection development GO:0031175 9.7 CDK5 GSK3B MAPT
3 ossification GO:0001503 9.58 CDH11 TNFRSF11A TNFSF11
4 regulation of microtubule cytoskeleton organization GO:0070507 9.56 GSK3B MAPT
5 cellular response to amyloid-beta GO:1904646 9.55 CDK5 GSK3B
6 osteoclast differentiation GO:0030316 9.54 TNFRSF11A TNFSF11
7 positive regulation of bone resorption GO:0045780 9.51 TNFRSF11A TNFSF11
8 monocyte chemotaxis GO:0002548 9.5 CALCA TNFRSF11A TNFSF11
9 mammary gland alveolus development GO:0060749 9.49 TNFRSF11A TNFSF11
10 regulation of protein localization to plasma membrane GO:1903076 9.48 CDK5 GBP1
11 central nervous system neuron development GO:0021954 9.46 CDK5 MAPT
12 regulation of calcium-mediated signaling GO:0050848 9.43 GBP1 MAPT
13 positive regulation of neuron death GO:1901216 9.43 CDK5 GSK3B MAPT
14 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFRSF11A TNFSF11
15 cellular response to nerve growth factor stimulus GO:1990090 9.27 MAPT
16 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
17 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
18 sodium-independent organic anion transport GO:0043252 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 9.32 GBP1 TNFRSF11A
2 tau-protein kinase activity GO:0050321 9.26 CDK5 GSK3B
3 dynactin binding GO:0034452 9.16 GSK3B MAPT
4 Hsp90 protein binding GO:0051879 9.13 CDK5 GBP1 MAPT
5 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO1A2 SLCO3A1 SLCO4A1

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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