MCID: ANR009
MIFTS: 43

Aneurysmal Bone Cysts

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 56 52 13 37
Aneurysmal Bone Cyst 58 29 17 32
Bone Cysts, Aneurysmal 71
Bone Cysts Aneurysmal 54

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

OMIM 56 606179
ICD10 32 M85.5
Orphanet 58 ORPHA480553
MedGen 41 C0152244
UMLS 71 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to osteoblastoma and telangiectatic osteogenic sarcoma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. The drug Denosumab has been mentioned in the context of this disorder. Affiliated tissues include Bone, endothelial and bone marrow.

Wikipedia : 74 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

More information from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 osteoblastoma 31.2 USP6 CDH11
2 telangiectatic osteogenic sarcoma 31.1 USP6 CDH11
3 pseudosarcomatous fibromatosis 30.5 USP6 CDH11
4 fibrous dysplasia 30.0 TNFSF11 TNFRSF11A CALCA
5 benign giant cell tumor 29.5 USP6 TNFSF11 TNFRSF11A CALCA
6 giant cell reparative granuloma 29.3 USP6 TNFSF11 TNFRSF11A CALCA
7 bone giant cell tumor 29.3 USP6 TNFSF11 TNFRSF11A CALCA
8 cherubism 29.3 USP6 TNFSF11 CALCA
9 tooth resorption 28.9 TNFSF11 TNFRSF11A CALCA
10 root resorption 28.7 TNFSF11 TNFRSF11A CALCA
11 mammary paget's disease 28.7 TNFSF11 TNFRSF11A CALCA
12 paget's disease of bone 28.6 TNFSF11 TNFRSF11A CALCA
13 bone resorption disease 28.6 TNFSF11 TNFRSF11A CALCA
14 bone cancer 28.5 TNFSF11 TNFRSF11A CALCA
15 osteogenic sarcoma 10.7
16 fibroma 10.6
17 chondroblastoma 10.6
18 ossifying fibroma 10.5
19 exophthalmos 10.5
20 back pain 10.4
21 myositis 10.4
22 paraplegia 10.4
23 myositis ossificans 10.4
24 chondromyxoid fibroma 10.3
25 hyperparathyroidism 10.3
26 solitary bone cyst 10.3
27 mccune-albright syndrome 10.2
28 chondrosarcoma 10.2
29 hemangioma 10.2
30 fasciitis 10.2
31 headache 10.2
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
33 scoliosis 10.2
34 chondroma 10.2
35 radiculopathy 10.2
36 juvenile ossifying fibroma 10.2
37 rare tumor 10.2
38 alzheimer disease 14 10.2 MAPT GSK3B
39 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
40 hydrocephalus 10.1
41 fibrous histiocytoma 10.1
42 paresthesia 10.1
43 torticollis 10.1
44 ameloblastoma 10.1
45 horner's syndrome 10.1
46 facial paralysis 10.1
47 fibrosarcomatous osteosarcoma 10.1
48 intracranial hypertension 10.1
49 enchondroma 10.1
50 head injury 10.1

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM:

606179

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts Recruiting NCT03066245 Phase 1, Phase 2
3 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

40
Bone, Endothelial, Bone Marrow, Spinal Cord, Lung, Testes, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 2189)
# Title Authors PMID Year
1
Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts. 61 56
11408073 2001
2
Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. 61 56
10502326 1999
3
Aneurysmal bone cysts. A clinicopathologic study of 66 cases. 56 61
5458269 1970
4
Percutaneous intralesional injection of calcitonin and methylprednisolone for treatment of an aneurysmal bone cyst at C-2. 54 61
18976109 2008
5
Aneurysmal bone cyst at C2: imaging evaluation after intralesional injection of calcitonin and methylprednisolone. 61 54
18949268 2008
6
[Aneurysmal bone cyst of the cranial base treated by partial resection and calcitonin injection. A case report]. 61 54
16609661 2006
7
Aneurysmal bone cyst of the first cervical vertebrae in a child treated with percutaneous intralesional injection of calcitonin and methylprednisolone. A case report. 54 61
10707403 2000
8
Sciatica secondary to an aneurysmal bone cyst treated with in situ calcitonin injections. 61 54
9385701 1997
9
Calcitonin therapy of aneurysmal bone cysts. 61 54
1400569 1992
10
Bone Tumors: Benign Bone Tumors. 61
32573182 2020
11
Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases. 61
32036238 2020
12
Successful Intravascular Treatment of an Intraosseous Arteriovenous Fistula in Fibrous Dysplasia. 61
32556405 2020
13
Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia-a systematic review. 61
32040603 2020
14
Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst. 61
32011035 2020
15
[Tumor-like bony lesions of the skeleton]. 61
32556370 2020
16
[Metacarpal shaft reconstruction using medial femoral condyle flap: A case report]. 61
32359727 2020
17
Biologic osteosynthesis in the treatment of benign and malignant bone tumors. 61
32557602 2020
18
Tailored treatment of aneurysmal bone cyst of the scapula: en bloc resection for the body and extended curettage for the neck and acromion. 61
31759878 2020
19
Prognostic role of PD-L1 and immune-related gene expression profiles in giant cell tumors of bone. 61
32377818 2020
20
Chondromesenchymal hamartomas in a 24-year-old male mimicking a posterior mediastinal tumor and a 5-month-old boy with postoperative disseminated intravascular coagulation: two case reports. 61
32398154 2020
21
Knee intra-articular extraskeletal aneurysmal bone cyst: a case report and review of literature. 61
32435899 2020
22
Hemorrhagic Fibrous Dysplasia with Acute Neurological Decline: Case Report and Review of the Literature. 61
32437991 2020
23
Total Calcanectomy and Bilateral Iliac Bone Autograft Reconstruction for the Treatment of Calcaneal Chondroblastoma Involving a Secondary Aneurysmal Bone Cyst: A Case Report and Literature Review. 61
32354519 2020
24
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. 61
29489506 2020
25
Orbital Aneurysmal Bone Cyst in a Patient With McCune-Albright Syndrome. 61
32251179 2020
26
The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. 61
32248448 2020
27
Two cases of paralysis secondary to aneurysmal bone cysts with complete neurologic recovery. 61
32048217 2020
28
Cervical Spine Aneurysmal Bone Cyst in a Pediatric Patient: Embolization Considerations and Potential Pitfalls. 61
32305612 2020
29
Brown tumor of the iliac crest initially misdiagnosed as a giant cell tumor of the bone. 61
32478667 2020
30
Skull base aneurysmal bone cyst presenting with hydrocephalus: progressive residuum obliterated by Gamma Knife stereotactic radiosurgery in a pediatric patient. 61
32244207 2020
31
Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls. 61
32342641 2020
32
Percutaneous alcohol-based sclerotherapy in aneurysmal bone cyst in children and adolescents. 61
32359956 2020
33
Surgical clavicle reconstruction after aneurysmal bone cyst resection in a child: A simple method. 61
32315280 2020
34
Validating the management paradigm for pediatric spinal aneurysmal bone cysts to optimize long-term outcomes: an institutional experience. 61
32130482 2020
35
An Unusual Case of Aneurysmal Bone Cyst of Proximal Phalanx in a 2 Year Old Child. 61
32000601 2020
36
Atraumatic groin pain secondary to an aneurysmal bone cyst: A case report and literature review. 61
32280609 2020
37
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2020
38
Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion. 61
32157177 2020
39
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region. 61
31950466 2020
40
Leiomyosarcoma of the femur arising from an aneurysmal bone cyst treated seven years before: A case report and literature review. 61
32229164 2020
41
Huge aneurysmal bone cyst secondary to giant cell tumor of the hand phalanx: a case report and related literature. 61
32192464 2020
42
Can Giant Cell Tumor of the Bone Occur in the Skeletally Immature? 61
32556225 2020
43
Giant cell tumour of tendon sheath mimicking nodal osteoarthritis. 61
32079586 2020
44
Imaging of skull vault tumors in adults. 61
32056014 2020
45
[Expression of H3.3 G34W mutant-specific antibody in giant cell tumors of bone and its diagnostic value]. 61
32074722 2020
46
Rare aneurysmal bone cysts: multifocal, extraosseous, and surface variants. 61
32107639 2020
47
Primary aneurysmal bone cysts. 61
32009434 2020
48
Primary Aneurysmal Bone Cyst of the Thoracic Spine: A Pediatric Case Report. 61
31678311 2020
49
Secondary aneurysmal bone cyst of the spine: Clinicopathological features, surgical modalities and outcomes. 61
31760255 2020
50
Tailored Posterior-Only Approach for C2 Vertebral Body Lesions: Our Surgical Experience in 10 Patients. 61
31605844 2020

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
2 plasma membrane GO:0005886 9.36 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
3 axon GO:0030424 9.26 MAPT GSK3B CDK5 CALCA

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 TNFSF11 TNFRSF11A SLCO3A1
2 neuron projection development GO:0031175 9.67 MAPT GSK3B CDK5
3 ossification GO:0001503 9.61 TNFSF11 TNFRSF11A CDH11
4 cellular response to nerve growth factor stimulus GO:1990090 9.57 MAPT CALCA
5 regulation of microtubule cytoskeleton organization GO:0070507 9.56 MAPT GSK3B
6 osteoclast differentiation GO:0030316 9.55 TNFSF11 TNFRSF11A
7 regulation of protein localization to plasma membrane GO:1903076 9.52 GBP1 CDK5
8 positive regulation of bone resorption GO:0045780 9.51 TNFSF11 TNFRSF11A
9 monocyte chemotaxis GO:0002548 9.5 TNFSF11 TNFRSF11A CALCA
10 mammary gland alveolus development GO:0060749 9.48 TNFSF11 TNFRSF11A
11 central nervous system neuron development GO:0021954 9.46 MAPT CDK5
12 positive regulation of neuron death GO:1901216 9.43 MAPT GSK3B CDK5
13 regulation of calcium-mediated signaling GO:0050848 9.4 MAPT GBP1
14 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFSF11 TNFRSF11A
15 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFSF11 TNFRSF11A
16 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
17 sodium-independent organic anion transport GO:0043252 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau-protein kinase activity GO:0050321 9.26 GSK3B CDK5
2 dynactin binding GO:0034452 9.16 MAPT GSK3B
3 Hsp90 protein binding GO:0051879 9.13 MAPT GBP1 CDK5
4 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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