MCID: ANR009
MIFTS: 43

Aneurysmal Bone Cysts

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Aneurysmal Bone Cysts

MalaCards integrated aliases for Aneurysmal Bone Cysts:

Name: Aneurysmal Bone Cysts 57 20 13 37
Aneurysmal Bone Cyst 58 29 17 32
Bone Cysts, Aneurysmal 70
Bone Cysts Aneurysmal 54

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

OMIM® 57 606179
ICD10 32 M85.5
Orphanet 58 ORPHA480553
MedGen 41 C0152244
UMLS 70 C0152244

Summaries for Aneurysmal Bone Cysts

MalaCards based summary : Aneurysmal Bone Cysts, also known as aneurysmal bone cyst, is related to telangiectatic osteogenic sarcoma and osteoblastoma, and has symptoms including pain An important gene associated with Aneurysmal Bone Cysts is ANBC (Aneurysmal Bone Cysts), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease. The drug Denosumab has been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and spinal cord.

Wikipedia : 73 Aneurysmal bone cyst, abbreviated ABC, is an osteolytic bone neoplasm characterized by several... more...

More information from OMIM: 606179

Related Diseases for Aneurysmal Bone Cysts

Diseases related to Aneurysmal Bone Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 telangiectatic osteogenic sarcoma 30.8 USP6 CDH11
2 osteoblastoma 30.7 USP6 CDH11
3 pseudosarcomatous fibromatosis 30.2 USP6 CDH11
4 chondroblastoma 30.1 USP6 TNFSF11
5 fibrous dysplasia 30.0 TNFSF11 TNFRSF11A CALCA
6 benign giant cell tumor 29.9 TNFSF11 TNFRSF11A CALCA
7 cherubism 29.7 USP6 TNFSF11 CALCA
8 tooth resorption 29.4 TNFSF11 TNFRSF11A CALCA
9 connective tissue benign neoplasm 29.3 USP6 TNFSF11
10 giant cell reparative granuloma 29.2 USP6 TNFSF11 TNFRSF11A CALCA
11 bone giant cell tumor 29.2 USP6 TNFSF11 TNFRSF11A CALCA
12 root resorption 29.2 TNFSF11 TNFRSF11A CALCA
13 mammary paget's disease 29.2 TNFSF11 TNFRSF11A CALCA
14 bone resorption disease 29.2 TNFSF11 TNFRSF11A CALCA
15 paget's disease of bone 29.2 TNFSF11 TNFRSF11A CALCA
16 brittle bone disorder 29.1 TNFSF11 TNFRSF11A CALCA
17 bone cancer 29.1 TNFSF11 TNFRSF11A CALCA
18 osteogenic sarcoma 10.5
19 myositis 10.5
20 myositis ossificans 10.5
21 hyperparathyroidism 10.4
22 back pain 10.4
23 fibroma 10.4
24 scoliosis 10.3
25 hemangioma 10.3
26 rare tumor 10.3
27 ossifying fibroma 10.3
28 juvenile ossifying fibroma 10.3
29 hydrocephalus 10.3
30 fibrous histiocytoma 10.3
31 ischemic fasciitis 10.2 USP6 CDH11
32 mccune-albright syndrome 10.2
33 exophthalmos 10.2
34 paresthesia 10.2
35 solitary bone cyst 10.2
36 ameloblastoma 10.2
37 horner's syndrome 10.2
38 facial paralysis 10.2
39 head injury 10.2
40 avascular necrosis 10.2
41 chondrosarcoma 10.1
42 pulmonary embolism 10.1
43 chondromyxoid fibroma 10.1
44 renal cell carcinoma, nonpapillary 10.1
45 sarcoma, synovial 10.1
46 yemenite deaf-blind hypopigmentation syndrome 10.1
47 langerhans cell histiocytosis 10.1
48 bone disease 10.1
49 primary hyperparathyroidism 10.1
50 arteriovenous malformation 10.1

Graphical network of the top 20 diseases related to Aneurysmal Bone Cysts:



Diseases related to Aneurysmal Bone Cysts

Symptoms & Phenotypes for Aneurysmal Bone Cysts

Clinical features from OMIM®:

606179 (Updated 05-Apr-2021)

UMLS symptoms related to Aneurysmal Bone Cysts:


pain

Drugs & Therapeutics for Aneurysmal Bone Cysts

Drugs for Aneurysmal Bone Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 2 615258-40-7

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
2 Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts Recruiting NCT03066245 Phase 1, Phase 2
3 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Aneurysmal Bone Cysts

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Aneurysmal Bone Cysts cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal cell transplantation for bone cysts
Embryonic/Adult Cultured Cells Related to Aneurysmal Bone Cysts:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Aneurysmal Bone Cysts

Genetic tests related to Aneurysmal Bone Cysts:

# Genetic test Affiliating Genes
1 Aneurysmal Bone Cyst 29

Anatomical Context for Aneurysmal Bone Cysts

MalaCards organs/tissues related to Aneurysmal Bone Cysts:

40
Bone, Bone Marrow, Spinal Cord, Lung, Smooth Muscle, Kidney, Thyroid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Aneurysmal Bone Cysts:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Aneurysmal Bone Cysts

Articles related to Aneurysmal Bone Cysts:

(show top 50) (show all 2272)
# Title Authors PMID Year
1
Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts. 57 61
11408073 2001
2
Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. 61 57
10502326 1999
3
Aneurysmal bone cysts. A clinicopathologic study of 66 cases. 57 61
5458269 1970
4
Percutaneous intralesional injection of calcitonin and methylprednisolone for treatment of an aneurysmal bone cyst at C-2. 54 61
18976109 2008
5
Aneurysmal bone cyst at C2: imaging evaluation after intralesional injection of calcitonin and methylprednisolone. 54 61
18949268 2008
6
[Aneurysmal bone cyst of the cranial base treated by partial resection and calcitonin injection. A case report]. 61 54
16609661 2006
7
Aneurysmal bone cyst of the first cervical vertebrae in a child treated with percutaneous intralesional injection of calcitonin and methylprednisolone. A case report. 61 54
10707403 2000
8
Sciatica secondary to an aneurysmal bone cyst treated with in situ calcitonin injections. 54 61
9385701 1997
9
Calcitonin therapy of aneurysmal bone cysts. 54 61
1400569 1992
10
A rare presentation of primary lymphoma of bone with aneurysmal bone cyst-like changes. 61
33044565 2021
11
Clinicopathological and molecular characterisation of USP6-rearranged soft tissue neoplasms: the evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity. 61
33000481 2021
12
Impact of Secondary Aneurysmal Bone Cysts on Survival of Patients with Enneking Stage IIB Extremity Osteosarcoma: A Propensity Score Matching Analysis. 61
33811304 2021
13
Surgical Strategy of Pediatric Benign Sacral Tumors. 61
33655901 2021
14
Denosumab Treatment for Giant Cell Tumors, Aneurysmal Bone Cysts, and Fibrous Dysplasia-Risks and Benefits. 61
33616817 2021
15
An assessment of fluid-fluid levels on magnetic resonance imaging of spinal tumours. 61
32978680 2021
16
Aneurysmal Bone Cysts of the Paranasal Sinuses: The Mayo Clinic Experience and Review of the Literature. 61
33646602 2021
17
Qualitative evaluation of MRI features in aneurysmal bone cysts after percutaneous sclerotherapy. 61
32929547 2021
18
Ubiquitin-specific Peptidase 6 (USP6)-associated Fibroblastic/Myofibroblastic Tumors: Evolving Concepts. 61
33608306 2021
19
Open Curettage With Bone Augmentation for Symptomatic Tumors and Tumor-like Lesions of Calcaneus: A Comparison of Bioactive Glass Versus Allogeneic Bone. 61
33781640 2021
20
Severe Acute Lung Injury After H2O2 Irrigation of an Aneurysmal Bone Cyst in an 8-Year-Old Girl: A Case Report. 61
33710986 2021
21
Is percutaneous injection of bone marrow concentrate, demineralized bone matrix and PRF an alternative to curettage and bone grafting for treating aneurysmal bone cyst? 61
33462983 2021
22
Aneurysmal bone cyst of the foot: A series of 10 cases. 61
33715952 2021
23
Aneurysmal bone cyst and osteoblastoma: an extremely rare combination in the pediatric spine. 61
33083998 2021
24
Percutaneous Microwave Ablation and Osteoplasty of an Aneurysmal Bone Cyst. 61
33684538 2021
25
Differential diagnosis of T2 hypointense masses in musculoskeletal MRI. 61
33651128 2021
26
Aneurysmal Bone Cyst of the Medial Cuneiform: A Case Report. 61
33690802 2021
27
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions. 61
33558945 2021
28
Optic disc edema in fibrous dysplasia/McCune-Albright syndrome: Prevalence, etiologies, and clinical implications. 61
32979536 2021
29
YJ5 as an immunohistochemical marker of osteogenic lineage. 61
33187685 2021
30
Percutaneous treatments of primary aneurysmal bone cysts: systematic review and meta-analysis. 61
33550464 2021
31
CT and MRI features of giant cell tumours with prominent aneurysmal bone cysts in the extremities: a comparison with primary aneurysmal bone cysts. 61
32998832 2021
32
Efficacy of treatment interventions for primary aneurysmal bone cysts: a systematic review. 61
33622046 2021
33
En Bloc Resection for a Malignant Spine Tumor After Balloon Kyphoplasty: Histological Findings of a Retrieved Vertebral Body: A Case Report. 61
33625128 2021
34
An Intraoperative Surprise! A Rare Case Report of Primary Craniovertebral Junction Hydatid Disease Mimicking a Bony Tumor. 61
33220475 2021
35
Fluid-fluid Levels in Musculoskeletal Tumor Imaging. 61
32767947 2021
36
Orbital Aneurysmal Bone Cyst in a Patient With McCune-Albright Syndrome. 61
32251179 2021
37
H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors. 61
33021329 2021
38
Fine-Needle Aspiration Cytology in Preoperative Diagnosis of Bone Lesions: A Three-Year Study in a Tertiary Care Hospital. 61
33181515 2021
39
Rehabilitation of a child with a complicated aneurysmal bone cyst. 61
33427696 2021
40
Pediatric Tumor Management: Current and Controversial. 61
33438927 2021
41
Aneurysmal bone cyst of the head & neck: A review of reported cases in the literature. 61
33529841 2021
42
Soft tissue aneurysmal bone cyst of left hemithorax with review of literature. 61
33531740 2021
43
Efficacy of Lesion Specific Portals in Endoscopic Treatment of Calcaneal Bone Cyst: A Case Report and Literature Review. 61
33530595 2021
44
Analysis for clinical feature and outcome of chondroblastoma after surgical treatment: A single center experience of 92 cases. 61
33419623 2021
45
Identification of EWSR1-NFATC2 fusion in simple bone cysts. 61
33316098 2020
46
Chondroblastoma Expresses RANKL by RNA In Situ Hybridization and May Respond to Denosumab Therapy. 61
32826531 2020
47
Primary aneurysmal bone cyst of sacrum for adolescent: Eleven cases experience and literature review. 61
33317747 2020
48
In Reply to the Letter to the Editor Regarding "Primary Aneurysmal Bone Cyst of the Thoracic Spine: A Pediatric Case Report". 61
33227865 2020
49
Letter to the Editor Regarding "Primary Aneurysmal Bone Cyst of the Thoracic Spine: A Pediatric Case Report". 61
33227864 2020
50
USP6-Associated Neoplasms: A Rapidly Expanding Family of Lesions. 61
32635781 2020

Variations for Aneurysmal Bone Cysts

Expression for Aneurysmal Bone Cysts

Search GEO for disease gene expression data for Aneurysmal Bone Cysts.

Pathways for Aneurysmal Bone Cysts

GO Terms for Aneurysmal Bone Cysts

Cellular components related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
2 plasma membrane GO:0005886 9.36 USP6 TNFSF11 TNFRSF11A SLCO4A1 SLCO3A1 SLCO1A2
3 axon GO:0030424 9.26 MAPT GSK3B CDK5 CALCA

Biological processes related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 TNFSF11 TNFRSF11A SLCO3A1
2 neuron projection development GO:0031175 9.65 MAPT GSK3B CDK5
3 ossification GO:0001503 9.61 TNFSF11 TNFRSF11A CDH11
4 cellular response to nerve growth factor stimulus GO:1990090 9.57 MAPT CALCA
5 regulation of microtubule cytoskeleton organization GO:0070507 9.56 MAPT GSK3B
6 osteoclast differentiation GO:0030316 9.55 TNFSF11 TNFRSF11A
7 regulation of protein localization to plasma membrane GO:1903076 9.52 GBP1 CDK5
8 positive regulation of bone resorption GO:0045780 9.51 TNFSF11 TNFRSF11A
9 monocyte chemotaxis GO:0002548 9.5 TNFSF11 TNFRSF11A CALCA
10 central nervous system neuron development GO:0021954 9.49 MAPT CDK5
11 mammary gland alveolus development GO:0060749 9.46 TNFSF11 TNFRSF11A
12 positive regulation of neuron death GO:1901216 9.43 MAPT GSK3B CDK5
13 regulation of calcium-mediated signaling GO:0050848 9.4 MAPT GBP1
14 TNFSF11-mediated signaling pathway GO:0071847 9.37 TNFSF11 TNFRSF11A
15 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFSF11 TNFRSF11A
16 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
17 sodium-independent organic anion transport GO:0043252 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Molecular functions related to Aneurysmal Bone Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tau-protein kinase activity GO:0050321 9.26 GSK3B CDK5
2 dynactin binding GO:0034452 9.16 MAPT GSK3B
3 Hsp90 protein binding GO:0051879 9.13 MAPT GBP1 CDK5
4 sodium-independent organic anion transmembrane transporter activity GO:0015347 8.8 SLCO4A1 SLCO3A1 SLCO1A2

Sources for Aneurysmal Bone Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....