MCID: ANG050
MIFTS: 28

Angiocentric Glioma

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Angiocentric Glioma

MalaCards integrated aliases for Angiocentric Glioma:

Name: Angiocentric Glioma 58 71

Characteristics:

Orphanet epidemiological data:

58
angiocentric glioma
Prevalence: <1/1000000 (Worldwide); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C2363903
Orphanet 58 ORPHA251671
UMLS 71 C2363903

Summaries for Angiocentric Glioma

MalaCards based summary : Angiocentric Glioma is related to malignant ependymoma and encephalomalacia. An important gene associated with Angiocentric Glioma is MYB (MYB Proto-Oncogene, Transcription Factor), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Cell adhesion_Cadherin-mediated cell adhesion. Affiliated tissues include brain, spinal cord and temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Angiocentric Glioma

Diseases related to Angiocentric Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 malignant ependymoma 30.2 IDH1 GFAP
2 encephalomalacia 30.0 S100B GFAP
3 obstructive hydrocephalus 29.8 SYP GFAP
4 neurilemmoma 29.6 VIM S100B GFAP ACTC1
5 central nervous system cancer 29.4 SYP IDH1 GFAP
6 benign ependymoma 29.3 VIM SYP S100B GFAP
7 pilomyxoid astrocytoma 29.3 SYP QKI IDH1 GFAP
8 astroblastoma 29.3 VIM SYP IDH1 GFAP
9 juvenile pilocytic astrocytoma 29.0 SYP S100B IDH1 GFAP
10 dysembryoplastic neuroepithelial tumor 28.8 SYP S100B IDH1 GFAP
11 anaplastic ependymoma 28.7 VIM SYP S100B GFAP
12 ganglioglioma 28.7 VIM SYP S100B GFAP
13 hydrocephalus 28.7 VIM SYP S100B GFAP
14 oligodendroglioma 28.4 VIM SYP S100B IDH1 GFAP
15 medulloblastoma 27.7 VIM SYP S100B IDH1 GFAP ACTC1
16 glioma 10.9
17 glial tumor 10.9
18 cellular ependymoma 10.4
19 astrocytoma 10.4
20 anaplastic ganglioglioma 10.3 GFAP ACTC1
21 epilepsy 10.3
22 rare tumor 10.3
23 lymphangiectasis 10.2 VIM ACTC1
24 spinal cord astrocytoma 10.2 IDH1 GFAP
25 intravascular papillary endothelial hyperplasia 10.2 VIM ACTC1
26 glomangiomyoma 10.2 VIM ACTC1
27 benign metastasizing leiomyoma 10.2 VIM ACTC1
28 angiolipoma 10.2 VIM ACTC1
29 glomangioma 10.2 VIM ACTC1
30 primitive neuroectodermal tumor of the cervix uteri 10.2 VIM GFAP
31 spindle cell lipoma 10.2 VIM ACTC1
32 reticulum cell sarcoma 10.2 VIM ACTC1
33 spinal cord glioma 10.2 IDH1 GFAP
34 focal epilepsy 10.2
35 rare epilepsy 10.2
36 mixed glioma 10.2 IDH1 GFAP
37 frontal convexity meningioma 10.1 IDH1 GFAP
38 cogan syndrome 10.1 PTPRJ GFAP
39 epithelioid leiomyosarcoma 10.1 VIM ACTC1
40 myopericytoma 10.1 S100B ACTC1
41 chondromyxoid fibroma 10.1 VIM ACTC1
42 malignant giant cell tumor 10.1 S100B ACTC1
43 adenofibroma 10.1 VIM ACTC1
44 intracranial cysts 10.1 S100B GFAP
45 cystic nephroma 10.1 VIM ACTC1
46 congenital fibrosarcoma 10.1 VIM ACTC1
47 malignant giant cell tumor of soft parts 10.1 S100B ACTC1
48 epithelial-myoepithelial carcinoma 10.1 VIM ACTC1
49 adenosarcoma 10.1 VIM ACTC1
50 sarcomatoid mesothelioma 10.1 VIM ACTC1

Graphical network of the top 20 diseases related to Angiocentric Glioma:



Diseases related to Angiocentric Glioma

Symptoms & Phenotypes for Angiocentric Glioma

GenomeRNAi Phenotypes related to Angiocentric Glioma according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.68 MYB
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.68 ACTC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.68 MYB
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 MYB
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.68 ACTC1 MYB
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.68 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.68 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 IDH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 ACTC1 IDH1 MYB
10 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 MYB
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.68 MYB
12 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.68 MYB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 MYB
14 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.68 MYB
15 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.68 ACTC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.68 ACTC1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.68 IDH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 IDH1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.68 MYB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.68 MYB

MGI Mouse Phenotypes related to Angiocentric Glioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 ACTC1 GFAP MYB PTPRJ S100B SYP

Drugs & Therapeutics for Angiocentric Glioma

Search Clinical Trials , NIH Clinical Center for Angiocentric Glioma

Genetic Tests for Angiocentric Glioma

Anatomical Context for Angiocentric Glioma

MalaCards organs/tissues related to Angiocentric Glioma:

40
Brain, Spinal Cord, Temporal Lobe, Eye, Pineal, Cortex, Cerebellum

Publications for Angiocentric Glioma

Articles related to Angiocentric Glioma:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Angiocentric glioma: Drop Metastases to the Spinal Cord. 61
31953098 2020
2
Temporal lobe angiocentric glioma with oligodendroglioma-like areas: a rare association of an uncommon tumor. A case report with review of literature. 61
31897632 2020
3
Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. 61
31595628 2020
4
Angiocentric glioma mimicking encephalomalacia. 61
30976372 2019
5
Advances in Diagnostic Immunohistochemistry for Primary Tumors of the Central Nervous System. 61
30720470 2019
6
Angiocentric Glioma: Report of a Rare Case Presenting with Psychosis. 61
30459891 2018
7
[BRAF V600E mutation and clinicopathologic characteristics in 250 cases of brain tumors associated with epilepsy]. 61
30220118 2018
8
Brainstem angiocentric glioma: report of 2 cases. 61
28753090 2017
9
Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. 61
28776091 2017
10
Characterization of gliomas: from morphology to molecules. 61
28674742 2017
11
The epileptology of Koolen-de Vries syndrome: Electro-clinico-radiologic findings in 31 patients. 61
28440867 2017
12
Posterior cortex epilepsy surgery in childhood and adolescence: Predictors of long-term seizure outcome. 61
28098941 2017
13
Angiocentric Glioma in an Elderly Patient: Case Report and Review of the Literature. 61
27756673 2017
14
Angiocentric Glioma: The Infiltrative Glioma with Ependymal Differentiation. 61
24913299 2017
15
Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential. 61
27742374 2016
16
[Epilepsy-associated tumors of the central nervous system: Epilepsy surgery and oncological aspects]. 61
26676655 2016
17
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. 61
26829751 2016
18
Angiocentric glioma of hippocampus-report of a rare intractable epilepsy-related tumor. 61
26954821 2016
19
Angiocentric glioma from a perspective of A-B-C classification of epilepsy associated tumors. 61
27179220 2016
20
Rare glial tumors. 61
26948368 2016
21
"Unusual brain stone": heavily calcified primary neoplasm with some features suggestive of angiocentric glioma. 61
26024003 2015
22
MR Spectroscopic Profile of an Angiocentric Glioma. 61
26504061 2015
23
Cystoid angiocentric glioma: A case report and literature review. 61
26629293 2015
24
[A unusual brain cortical tumor: angiocentric glioma]. 61
25765138 2015
25
Angiocentric glioma: a report of nine new cases, including four with atypical histological features. 61
24861831 2015
26
Angiocentric glioma: a treatable cause of epilepsy: report of a rare case. 61
25591686 2014
27
Angiocentric glioma: a rare intractable epilepsy-related tumour in children. 61
25310736 2014
28
Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge. 61
24448703 2014
29
Intractable epilepsy due to angiocentric glioma: A case report and minireview. 61
24348765 2014
30
Angiocentric glioma. 61
24116979 2013
31
Cortical ependymoma with unusual histologic features. 61
23458270 2013
32
Angiocentric glioma: clinical, morphological, immunohistochemical and molecular features in three pediatric cases. 61
23073165 2013
33
Malignant glioma with angiocentric features. 61
23240849 2013
34
The treatment of angiocentric glioma: case report and literature review. 61
23596378 2013
35
Angiocentric glioma, a recently added WHO grade-I tumor. 61
27330646 2013
36
Refractory temporal lobe epilepsy caused by angiocentric glioma complicated with focal cortical dysplasia: a surgical case series. 61
23065092 2012
37
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. 61
23378871 2012
38
Adult-onset angiocentric glioma of epithelioid cell-predominant type of the mesial temporal lobe suggestive of a rare but distinct clinicopathological subset within a spectrum of angiocentric cortical ependymal tumors. 61
22151480 2012
39
Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. 61
22990729 2012
40
Isocitrate dehydrogenase 1 R132H mutation is not detected in angiocentric glioma. 61
22445362 2012
41
The high mitotic count detected by phospho-histone H3 immunostain does not alter the benign behavior of angiocentric glioma. 61
21892765 2012
42
Angiocentric glioma in a 4-year-old boy: imaging characteristics and review of the literature. 61
22226445 2012
43
Angiocentric glioma: a clinicopathologic review of 5 tumors with identification of associated cortical dysplasia. 61
21809996 2011
44
A case of angiocentric glioma with unusual clinical and radiological features. 61
21887397 2011
45
Anaplastic astrocytoma with angiocentric ependymal differentiation. 61
21062363 2011
46
Cortical ependymoma: an unusual epileptogenic lesion. 61
21235315 2011
47
Angiocentric glioma with high proliferative index: case report and review of the literature. 61
22075509 2011
48
Angiocentric glioma and surrounding cortical dysplasia manifesting as intractable frontal lobe epilepsy--case report. 61
21785249 2011
49
Coexistent pathology in chronic epilepsy patients with neoplasms. 61
20495542 2010
50
Angiocentric glioma with rich blood supply. 61
20399664 2010

Variations for Angiocentric Glioma

Expression for Angiocentric Glioma

Search GEO for disease gene expression data for Angiocentric Glioma.

Pathways for Angiocentric Glioma

Pathways related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 VIM SYP S100B GFAP
2 10.56 PTPRJ ACTC1

GO Terms for Angiocentric Glioma

Biological processes related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.46 S100B GFAP
2 muscle filament sliding GO:0030049 9.43 VIM ACTC1
3 positive regulation of collagen biosynthetic process GO:0032967 9.4 VIM MYB
4 regulation of neuronal synaptic plasticity GO:0048168 9.37 SYP S100B
5 positive regulation of glial cell proliferation GO:0060252 9.32 MYB GFAP
6 intermediate filament organization GO:0045109 9.26 VIM GFAP
7 astrocyte development GO:0014002 9.16 VIM GFAP
8 Bergmann glial cell differentiation GO:0060020 8.96 VIM GFAP
9 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Angiocentric Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 VIM SYP S100B IDH1 GFAP

Sources for Angiocentric Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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