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MCID: ANG011
MIFTS: 42

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiodysplasia

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MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 54 44 15 71
Angiodysplasia of Colon 71 32
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2494
MeSH 44 D016888
SNOMED-CT 67 71072006
ICD10 32 K55.2
UMLS 71 C0085411 C0267370
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Summaries for Angiodysplasia

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Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of colon, is related to angiodysplasia of intestine and telangiectasis. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Complement and coagulation cascades and Angiogenesis (CST). The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and endothelial, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 74 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

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Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 389)
# Related Disease Score Top Affiliating Genes
1 angiodysplasia of intestine 32.0 ATP4A ATP12A
2 telangiectasis 30.8 VEGFA ENG ACVRL1
3 weber syndrome 30.5 SST ENG ACVRL1
4 meckel diverticulum 30.3 SST ATP4A
5 hemorrhoid 30.3 ATP4A ATP12A
6 arteriovenous malformation 30.2 VEGFA ENG ANGPT2 ACVRL1
7 gastric antral vascular ectasia 30.1 SST ATP4A ATP12A
8 von willebrand disease, type 1 30.1 VWF SIGLEC5 F8
9 gastritis 30.1 SST SCT ATP4A
10 glucagonoma 30.0 SST SCT
11 bernard-soulier syndrome 30.0 VWF F8 F3
12 von willebrand's disease 30.0 VWF SIGLEC5 F8 F3 ADAMTS13
13 active peptic ulcer disease 29.9 VWF SST F3 ATP4A ATP12A ACVRL1
14 internal hemorrhoid 29.9 ATP4A ATP12A
15 duodenitis 29.9 ATP4A ATP12A
16 hereditary hemorrhagic telangiectasia 29.8 VWF VEGFA ENG ANGPT2 ACVRL1
17 multiple endocrine neoplasia, type i 29.8 SST SCT FGF2
18 intestinal perforation 29.7 VEGFA ATP4A ATP12A
19 acquired von willebrand syndrome 29.7 VWF F8 F3 ADAMTS13
20 liver cirrhosis 29.7 VEGFA SST SCT F3 ADAMTS13
21 esophageal varix 29.6 SST F3 ATP4A ATP12A
22 portal hypertension 29.6 VWF VEGFA SST F3 ADAMTS13
23 von willebrand disease, type 2 29.6 VWF SIGLEC5 F8 ADAMTS13
24 moyamoya disease 1 29.6 VWF VEGFA FGF2 F3
25 peripheral vascular disease 29.5 VWF VEGFA F3 ACVRL1
26 nephrosclerosis 29.5 VEGFA F3 ADAMTS13
27 disseminated intravascular coagulation 29.5 VWF F3 ADAMTS13
28 peptic ulcer disease 29.5 SST SCT ATP4A ATP12A
29 zollinger-ellison syndrome 29.5 SST SCT ATP4A ATP12A
30 hemophilia a 29.5 VWF F8 F3
31 thrombophilia due to thrombin defect 29.4 VWF F8 F3
32 glanzmann thrombasthenia 29.4 VWF F8 F3
33 pre-eclampsia 29.3 VWF VEGFA F3 ENG
34 hemangioma 29.3 VWF VEGFA FGF2 F3 ENG ANGPT2
35 lipoprotein quantitative trait locus 29.2 VWF VEGFA FGF2 F3 ENG
36 factor viii deficiency 29.1 VWF SIGLEC5 F8 F3
37 vascular disease 29.1 VWF VEGFA FGF2 F8 F3 ENG
38 hypertension, essential 28.4 VWF VEGFA SST FGF2 F3 ENG
39 myocardial infarction 28.4 VWF VEGFA FGF2 F8 F3 ENG
40 hemorrhagic disease 28.2 VWF VEGFA F8 F3 ATP4A ATP12A
41 thrombocytopenia 28.1 VWF F8 F3 ENG ANGPT2 ADAMTS13
42 angioosteohypotrophic syndrome 11.0
43 nevada syndrome 10.9
44 chronic kidney disease 10.4
45 iron metabolism disease 10.4
46 infiltrating angiolipoma 10.4 VWF VEGFA
47 ulcer of lower limbs 10.4 VEGFA FGF2
48 radiation proctitis 10.3 VEGFA FGF2
49 carotid body cancer 10.3 VWF SST
50 capillary lymphangioma 10.3 VWF ENG

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia
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Symptoms & Phenotypes for Angiodysplasia

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MGI Mouse Phenotypes related to Angiodysplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 ACVRL1 ANGPT2 ATP12A ATP4A ENG SST
2 hematopoietic system MP:0005397 9.85 ACVRL1 ADAMTS13 ANGPT2 ATP4A ENG F3
3 homeostasis/metabolism MP:0005376 9.73 ACVRL1 ADAMTS13 ANGPT2 ATP12A ATP4A ENG
4 mortality/aging MP:0010768 9.36 ACVRL1 ADAMTS13 ANGPT2 ATP4A ENG F3
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Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 2, Phase 3 51110-01-1, 38916-34-6 53481605
2
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
3 Antineoplastic Agents, Hormonal Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3
5
Pasireotide Approved Phase 2 396091-73-9 9941444
6
Iron Approved Phase 2 7439-89-6 23925 29936
7
Ferrous succinate Approved Phase 2 10030-90-7
8 Hormone Antagonists Phase 2
9 Hormones Phase 2
10 Angiogenesis Inhibitors Phase 2
11 Immunologic Factors Phase 2
12 Immunosuppressive Agents Phase 2
13 Hematinics Phase 2
14 Anti-Infective Agents Phase 2
15 Anti-Bacterial Agents Phase 2
16
Pomalidomide Approved Phase 1 19171-19-8
17
Infliximab Approved 170277-31-3
18 Hemostatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Randomized, Open-label Clinical Trial Assessing the Efficacy of Octreotide in Decreasing Blood and Iron Requirements in Patients With Refractory Anaemia Due to Angiodysplasias Unknown status NCT02384122 Phase 2, Phase 3 Octreotide
2 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Unknown status NCT03302858 Phase 2
3 Randomized Phase II Trial Evaluating the Efficiency of Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
4 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation : An Open-label, Randomized, Parallel Controlled Study Completed NCT00964496 Phase 2 Thalidomide;Iron
5 A Phase I Single Arm Study to Assess the Safety and Efficacy of Pomalidomide in Patients With Bleeding Due to Hereditary Hemorrhagic Telangiectasia and Refractory Angiodysplasia Completed NCT02287558 Phase 1 Pomalidomide
6 A Randomized Controlled Trial of Capsule Endoscopy vs Standard Care in Patients With Iron Deficiency Anemia With Suspected Obscure / Occult Gastrointestinal Bleeding Completed NCT00694954
7 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule in Patients With Obscure Digestive Bleedings Completed NCT01820182
8 A Prospective Observational Cohort Study of Hemospray for Lower Gastrointestinal Hemorrhage (APPROACH LGI) Completed NCT02099435
9 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

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Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

40
Colon, Small Intestine, Endothelial, Pancreas, Appendix, Tongue, Lymph Node
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Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50) (show all 1456)
# Title Authors PMID Year
1
[Analysis of molecular background of hereditary haemorrhagic telangiectasia--Rendu-Osler-Weber disease--preliminary results]. 61 54
19205515 2008
2
DHPLC-based mutation analysis of ENG and ALK-1 genes in HHT Italian population. 61 54
16429404 2006
3
Gastrointestinal bleeding in von Willebrand disease. 61 54
16542710 2006
4
Early transfusion of factor VIII/von Willebrand factor concentrates seems to be effective in the treatment of gastrointestinal bleeding in patients with von Willebrand type III disease. 54 61
11554939 2001
5
Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 54 61
10187774 1999
6
A reappraisal of the pharmacologic management of gastrointestinal bleeding in patients with continuous flow left ventricular assist devices. 61
32870436 2021
7
Successful management of severe gastrointestinal bleeding from jejunal angiodysplasia in a patient with Bernard-Soulier syndrome. 61
33563678 2021
8
Acute Gastrointestinal Bleed from a Gastrointestinal Stromal Tumour Impersonating an Arteriovenous Malformation of the Jejunum. 61
33532109 2021
9
Medical Management of Heyde Syndrome. 61
33564544 2021
10
Thirty-day readmission rates, reasons, and costs for gastrointestinal angiodysplasia-related bleeding in the USA. 61
33405425 2021
11
Gastrointestinal Bleeding in Mechanical Cardiac Support. 61
32866039 2021
12
Experimental confirmation of the promising selective use of "green" laser radiation for photothermolysis of hemoglobin-containing tissues. 61
33420852 2021
13
Of aortic valve and bleeding: Heyde's syndrome. 61
33008701 2020
14
Gastrointestinal bleeding from angiodysplasia in von Willebrand disease: Improved diagnosis and outcome prediction using videocapsule on top of conventional endoscopy. 61
33113216 2020
15
Successful laparoscopic surgery combined with selective arterial embolization for bleeding due to jejunal angiodysplasia: a case report. 61
33129311 2020
16
Efficacy of a novel self-assembling peptide hemostatic gel as rescue therapy for refractory acute gastrointestinal bleeding. 61
32316041 2020
17
Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation. 61
32652743 2020
18
Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders. 61
32971146 2020
19
Diffuse telangiectasia of the colon: A case report. 61
32846752 2020
20
Coexistence of Von Willebrand disease and gastrointestinal stromal tumor (G.I.S.T): Case report of a rare and challenge association. 61
32444278 2020
21
Thalidomide for refractory gastrointestinal bleeding from vascular malformations in patients with significant comorbidities. 61
32874976 2020
22
Shared changes in angiogenic factors across gastrointestinal vascular conditions: A pilot study. 61
32844042 2020
23
Angiodysplasia in Renal Disease Patients: Analysis of Risk Factors and Approach to Manage Such Patients. 61
32953300 2020
24
Hereditary Hemorrhagic Telangiectasia in a Sickle Cell Trait Patient: A Report of a Rare Case with Use of Nuclear Medicine, and a Literature Review. 61
32614805 2020
25
Multicenter case series of patients with small-bowel angiodysplasias treated with a small-bowel radiofrequency ablation catheter. 61
32258850 2020
26
Arteriovenous malformation that caused prolapse of the colon and was treated surgically in an infant: a case report. 61
32270382 2020
27
Long-term treatment with thalidomide for severe recurrent hemorrhage from intestinal angiodysplasia in Glanzmann Thrombasthenia. 61
32200672 2020
28
Risk factors for bleeding from gastrointestinal angiodysplasia: a case-control study in patients with bleeding and non-bleeding angiodysplasia. 61
32018316 2020
29
Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature. 61
31378751 2020
30
The incidence, risk factors, and outcomes of gastrointestinal bleeding in patients with a left ventricular assist device: a Japanese single-center cohort study. 61
31705323 2020
31
Acute Lower Gastrointestinal Bleeding: Evaluation and Management. 61
32053333 2020
32
The combination of quantitative faecal occult blood test and faecal calprotectin is a cost-effective strategy to avoid colonoscopies in symptomatic patients without relevant pathology. 61
32523623 2020
33
Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy. 61
32337053 2020
34
Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018. 61
30009379 2020
35
Heyde Syndrome Complicated by a Dieulafoy Lesion. 61
33071670 2020
36
Angiodysplasia of the Gallbladder: An Unknown Risk Factor for Cholecystolithiasis. 61
32908760 2020
37
Angiodysplasia in terminal ileum: Case report and review of literature. 61
31862659 2020
38
Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature. 61
31498527 2020
39
The impact of inpatient capsule endoscopy on the need for therapeutic interventions in patients with obscure gastrointestinal bleeding. 61
31997779 2020
40
Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study. 61
32190042 2020
41
[Heyde syndrome successfully treated with transcatheter aortic valve implantation to prevent recurrence of gastrointestinal bleeding from angiodysplasia]. 61
32908111 2020
42
Thalidomide for the treatment of angiodysplasia-related recurrent gastrointestinal hemorrhage: Is low dose a safe and viable option? 61
31893059 2019
43
A histological description of intestinal 'angiodysplasia' in an autopsy case of Heyde's syndrome. 61
31872535 2019
44
Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000® left ventricular assist device. 61
31338629 2019
45
Expression of angiogenic factors in the uteroplacental unit is altered at time of placentation in a porcine model of von Willebrand disease type 1. 61
31806575 2019
46
New therapies for von Willebrand disease. 61
31808884 2019
47
New therapies for von Willebrand disease. 61
31714963 2019
48
Changes in Lower Gastrointestinal Bleeding Presentation, Management, and Outcomes Over a 10-Year Span. 61
31593973 2019
49
Transcatheter aortic valve implantation in a patient with suspected hereditary von Willebrand disease and severe gastrointestinal bleeding - a case report. 61
31324129 2019
50
Characterization of a Porcine Model for Von Willebrand Disease Type 1 and 3 Regarding Expression of Angiogenic Mediators in the Nonpregnant Female Reproductive Tract. 61
31526432 2019
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Variations for Angiodysplasia

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Expression for Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.
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Pathways for Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Complement and coagulation cascades 36 1
11.29 VWF F8 F3
2
Angiogenesis (CST) 4
10.97 VWF FGF2 F3 ENG ANGPT2
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GO Terms for Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 VEGFA F3 ENG ADAMTS13 ACVRL1
2 extracellular region GO:0005576 9.61 VWF VEGFA SST SCT FGF2 F8
3 extracellular space GO:0005615 9.36 VWF VEGFA SST SCT FGF2 F8
4 platelet alpha granule lumen GO:0031093 9.33 VWF VEGFA F8

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.81 VEGFA FGF2 ENG ACVRL1
2 blood coagulation GO:0007596 9.78 VWF F8 F3 ADAMTS13
3 platelet degranulation GO:0002576 9.76 VWF VEGFA F8
4 positive regulation of protein kinase B signaling GO:0051897 9.76 VEGFA FGF2 F3 ENG
5 platelet activation GO:0030168 9.72 VWF F8 ADAMTS13
6 response to hypoxia GO:0001666 9.71 VEGFA ENG ANGPT2 ACVRL1
7 angiogenesis GO:0001525 9.65 VEGFA FGF2 ENG ANGPT2 ACVRL1
8 cellular sodium ion homeostasis GO:0006883 9.61 ATP4A ATP12A
9 cell migration involved in sprouting angiogenesis GO:0002042 9.61 VEGFA FGF2
10 endocardial cushion morphogenesis GO:0003203 9.6 ENG ACVRL1
11 blood coagulation, intrinsic pathway GO:0007597 9.59 VWF F8
12 positive regulation of DNA biosynthetic process GO:2000573 9.58 VEGFA FGF2
13 sodium ion export across plasma membrane GO:0036376 9.57 ATP4A ATP12A
14 cellular potassium ion homeostasis GO:0030007 9.56 ATP4A ATP12A
15 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.54 ATP4A ATP12A
16 negative regulation of blood vessel endothelial cell migration GO:0043537 9.54 FGF2 ANGPT2 ACVRL1
17 positive regulation of positive chemotaxis GO:0050927 9.52 VEGFA F3
18 dorsal aorta morphogenesis GO:0035912 9.49 ENG ACVRL1
19 positive regulation of endothelial cell proliferation GO:0001938 9.46 VEGFA FGF2 F3 ACVRL1
20 positive regulation of epithelial tube formation GO:1905278 9.43 VEGFA FGF2
21 endocardial cushion to mesenchymal transition GO:0090500 9.32 ENG ACVRL1
22 hemostasis GO:0007599 9.26 VWF F8 F3 ADAMTS13
23 positive regulation of angiogenesis GO:0045766 9.1 VEGFA FGF2 F3 ENG ANGPT2 ACVRL1

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.54 VWF FGF2 ADAMTS13
2 activin binding GO:0048185 9.32 ENG ACVRL1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
4 transforming growth factor beta-activated receptor activity GO:0005024 9.16 ENG ACVRL1
5 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
6 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
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Sources for Angiodysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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