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MCID: ANG011
MIFTS: 45

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiodysplasia

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MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 55 44 15 72
Angiodysplasia of Colon 72 33
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2494
MeSH 44 D016888
SNOMED-CT 68 71072006
ICD10 33 K55.2
UMLS 72 C0085411 C0267370
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Summaries for Angiodysplasia

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Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of colon, is related to varicose veins and arteriovenous malformation. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and HIF-1-alpha transcription factor network. The drugs Thrombin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and endothelial, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 75 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

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Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 varicose veins 30.6 VWF VEGFA
2 arteriovenous malformation 30.4 VEGFA ENG ACVRL1
3 hereditary hemorrhagic telangiectasia 30.4 ENG ACVRL1
4 hemangioma 30.4 VEGFA FGF2 ANGPT2
5 telangiectasis 30.3 VEGFA ENG ACVRL1
6 angiosarcoma 30.3 VWF VEGFA
7 portal hypertension 29.9 VWF VEGFA SST
8 arteries, anomalies of 29.7 VWF VEGFA ACVRL1
9 glucagonoma 29.7 SST SCT
10 peripheral vascular disease 29.7 VWF VEGFA
11 gastrinoma 29.6 SST SCT
12 zollinger-ellison syndrome 29.6 SST SCT
13 duodenal ulcer 29.5 SST SCT
14 weber syndrome 29.5 SST ENG ACVRL1
15 pre-eclampsia 29.5 VWF VEGFA ENG
16 multiple endocrine neoplasia, type i 29.1 SST SCT FGF2
17 vascular disease 28.9 VWF VEGFA FGF2 ENG ACVRL1
18 angiodysplasia of intestine 12.2
19 angioosteohypotrophic syndrome 11.6
20 telangiectasia, hereditary hemorrhagic, type 4 11.3
21 nevada syndrome 11.2
22 von willebrand's disease 10.7
23 active peptic ulcer disease 10.5
24 infiltrating angiolipoma 10.5 VWF VEGFA
25 iron metabolism disease 10.5
26 deficiency anemia 10.4
27 lymphangiosarcoma 10.4 VWF VEGFA
28 kidney disease 10.4
29 radiation proctitis 10.4 VEGFA FGF2
30 poems syndrome 10.3 VEGFA FGF2
31 aortic valve disease 2 10.3
32 angiomatous meningioma 10.3 VEGFA FGF2
33 iron deficiency anemia 10.3
34 liver cirrhosis 10.3
35 vitreous disease 10.3 VEGFA FGF2
36 pyogenic granuloma 10.3 VEGFA ANGPT2
37 dupuytren contracture 10.3 VEGFA FGF2
38 angiomatosis 10.3
39 background diabetic retinopathy 10.3 VEGFA ANGPT2
40 lipodermatosclerosis 10.3 VEGFA ANGPT2
41 space motion sickness 10.3 SCT FGF2
42 acquired von willebrand syndrome 10.3
43 macular holes 10.2 VEGFA ANGPT2
44 klippel-trenaunay-weber syndrome 10.2
45 end stage renal failure 10.2
46 breast carcinoma in situ 10.2 VEGFA FGF2
47 glomeruloid hemangioma 10.2 VEGFA ENG
48 pericardial effusion 10.2 VEGFA FGF2
49 von willebrand disease, type 1 10.2
50 subvalvular aortic stenosis 10.2

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia
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Symptoms & Phenotypes for Angiodysplasia

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MGI Mouse Phenotypes related to Angiodysplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ACVRL1 ANGPT2 ENG FGF2 VEGFA VWF
2 digestive/alimentary MP:0005381 9.73 ACVRL1 ANGPT2 ENG SST VEGFA VWF
3 homeostasis/metabolism MP:0005376 9.7 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
4 mortality/aging MP:0010768 9.5 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
5 nervous system MP:0003631 9.1 ACVRL1 ENG FGF2 SST VEGFA VWF
Sources

Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
3
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
4
Phylloquinone Approved, Investigational Phase 4 84-80-0
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6
Dalteparin Approved Phase 4 9005-49-6
7 Bemiparin Approved, Investigational Phase 4 91449-79-5
8
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
9 Menaquinone Investigational Phase 4 1182-68-9
10 Fibrinolytic Agents Phase 4
11 naphthoquinone Phase 4
12 Heparin, Low-Molecular-Weight Phase 4
13 Vitamin K Phase 4
14 Anticoagulants Phase 4
15 calcium heparin Phase 4
16
Somatostatin Approved, Investigational Phase 2, Phase 3 38916-34-6, 51110-01-1 53481605
17
Iron Approved, Experimental Phase 2, Phase 3 15438-31-0, 7439-89-6 23925 27284
18
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
19 Gastrointestinal Agents Phase 2, Phase 3
20 Antineoplastic Agents, Hormonal Phase 2, Phase 3
21
Pasireotide Approved Phase 2 396091-73-9 9941444
22
Ferrous succinate Approved Phase 2 10030-90-7
23 Hormones Phase 2
24 Hormone Antagonists Phase 2
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
26 Hematinics Phase 2
27
Pomalidomide Approved Phase 1 19171-19-8
28
Infliximab Approved 170277-31-3
29 Cola
30 Hemostatics

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina
2 A Multicenter, Randomized, Open-label Clinical Trial Assessing the Efficacy of Octreotide in Decreasing Blood and Iron Requirements in Patients With Refractory Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
3 Randomized Phase II Trial Evaluating the Efficiency of Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
4 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation : An Open-label, Randomized, Parallel Controlled Study Completed NCT00964496 Phase 2 Thalidomide;Iron
6 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
7 A Randomised, Double-blind, Placebo-controlled Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
8 Safety and Efficacy of Octreotide LAR Depot in Left Ventricular Assist Device (LVAD) Associate Gastrointestinal (GI) Completed NCT01707225 Phase 1 Octreotide LAR Depot
9 A Phase I Single Arm Study to Assess the Safety and Efficacy of Pomalidomide in Patients With Bleeding Due to Hereditary Hemorrhagic Telangiectasia and Refractory Angiodysplasia Recruiting NCT02287558 Phase 1 Pomalidomide
10 Prophylactic Elective Clipping of Colonic Diverticula in Patients Who Have Had Sustained Lower Gastrointestinal Haemorrhage Unknown status NCT02094456
11 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
12 A Prospective Observational Cohort Study of Hemospray for Lower Gastrointestinal Hemorrhage (APPROACH LGI) Completed NCT02099435
13 A Randomized Controlled Trial of Capsule Endoscopy vs Standard Care in Patients With Iron Deficiency Anemia With Suspected Obscure / Occult Gastrointestinal Bleeding Completed NCT00694954
14 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule in Patients With Obscure Digestive Bleedings Completed NCT01820182
15 Comparison of Early Vs Delayed Feeding on Rebleeding Following Endoscopic Ligation for Acute Esophageal Variceal Bleeding Completed NCT03306095
16 A Multicentre Prospective Observational Study to Evaluate the Utilisation, Effectiveness and Safety of Purastat® in the Management of Gastrointestinal Bleeding Recruiting NCT03983707
17 Role of MSCT Angiography in Evaluation of Lower Gastrointestinal Bleeding Not yet recruiting NCT03464513
18 Yield of Colonoscopy in Children With Bleeding Per Rectum Attending Gastrointestinal Endoscopic Unit In Assuit University Children Hospital Not yet recruiting NCT03596320
19 Prospective Evaluation of Same Day Bidirectional Endoscopy for Occult Bleeding Terminated NCT00636597
20 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

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Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

41
Colon, Small Intestine, Endothelial, Liver, Kidney, Bone, Lung
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Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50) (show all 1417)
# Title Authors PMID Year
1
[Analysis of molecular background of hereditary haemorrhagic telangiectasia--Rendu-Osler-Weber disease--preliminary results]. 9 38
19205515 2008
2
DHPLC-based mutation analysis of ENG and ALK-1 genes in HHT Italian population. 9 38
16429404 2006
3
Gastrointestinal bleeding in von Willebrand disease. 9 38
16542710 2006
4
Early transfusion of factor VIII/von Willebrand factor concentrates seems to be effective in the treatment of gastrointestinal bleeding in patients with von Willebrand type III disease. 9 38
11554939 2001
5
Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 9 38
10187774 1999
6
Heyde Syndrome: Aortic Stenosis and Beyond. 38
31230737 2019
7
Thulium laser coagulation: a new effective endotherapy to treat gastrointestinal angiodysplasia. 38
31327343 2019
8
Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature. 38
31378751 2019
9
[Treatment of nonvariceal upper gastrointestinal bleeding: endoluminal-endovascular-surgical]. 38
31392464 2019
10
Gastrointestinal angiodysplasia in two patients with type 3 von Willebrand disease. 38
31261161 2019
11
Transcatheter aortic valve implantation in a patient with suspected hereditary von Willebrand disease and severe gastrointestinal bleeding - a case report. 38
31324129 2019
12
Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000® left ventricular assist device. 38
31338629 2019
13
Von Willebrand disease and gastrointestinal bleeding: A national inpatient sample study. 38
31026662 2019
14
Arteriovenous malformations within jejunal diverticulosis: case report and literature review. 38
31248400 2019
15
Is a bleeding scan prior to single-balloon enteroscopy necessary in patients with obscure gastrointestinal bleeding? 38
30473414 2019
16
Recurrent Gastrointestinal Bleeding from Dieulafoy's Lesions in a Patient with Type 1 von Willebrand Disease: A Rare Association. 38
31192289 2019
17
Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese. 38
30348493 2019
18
Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases. 38
30867356 2019
19
Risk factors for incidentally detected and symptomatic angiodysplasias: a case-control study with the general population as reference. 38
30562184 2019
20
Functional capillary impairment in patients with ventricular assist devices. 38
30976042 2019
21
Alarming Increasing Trends in Hospitalizations and Mortality With Heyde's Syndrome: A Nationwide Inpatient Perspective (2007 to 2014). 38
30660352 2019
22
[A Resected Case with Early Gastric Cancer That Was Overdiagnosed as Scirrhous Gastric Cancer]. 38
30914596 2019
23
A Two-Month-Old Child with Vascular Ectasia: A Case Report Diagnosed by Molecular Karyotyping. 38
30775049 2019
24
Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. 38
30485828 2019
25
Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease. 38
30837783 2019
26
Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement. 38
30834297 2019
27
Short article: Hormone therapy for severe gastrointestinal bleeding due to multiple angiodysplastic lesions. 38
30676471 2019
28
Multiple venous malformations in the left colon and rectum: a long-standing case managed conservatively and an update of current literature. 38
30902841 2019
29
Superselective Transcatheter Arterial Embolization in the Treatment of Angiodysplasia. 38
31205432 2019
30
Blood inflammatory and endothelial markers in women with von Willebrand disease. 38
30629692 2019
31
Acquired von Willebrand Syndrome and Chronic Anaemia: A Different Diagnostic Approach. 38
31293998 2019
32
Obscure gastrointestinal bleeding resulting from small bowel neoplasia; A case series. 38
31207533 2019
33
Clinical and endoscopic features of severe acute gastrointestinal bleeding in elderly patients treated with direct oral anticoagulants: a multicentre study. 38
31244894 2019
34
Gastrointestinal lesions in chronic kidney disease patients with anaemia. 38
30153940 2019
35
Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract. 38
30864370 2018
36
Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. Benefits in efficacy and procedures consumption. 38
30621520 2018
37
Same-day colon capsule endoscopy is a viable means to assess unexplored colonic segments after incomplete colonoscopy in selected patients. 38
30574326 2018
38
Polypoid angiodysplasia mimicking diverticular disease. 38
29884485 2018
39
Gastric Cancer, Hemophilia A and Angiodysplasia - An Unreported Association with Clinical Implications in a Patient with Digestive Hemorrhage. 38
30596373 2018
40
Initial experience of video capsule endoscopy at a tertiary center in Saudi Arabia. 38
30004041 2018
41
Successful Treatment of Recurrent Gastrointestinal Bleeding Due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide: Two Birds with One Stone 38
29911985 2018
42
Pazopanib effective for bevacizumab-unresponsive epistaxis in hereditary hemorrhagic telangiectasia. 38
29451965 2018
43
The etiology of potential small-bowel bleeding depending on patient's age and gender. 38
30288279 2018
44
An overview of angiodysplasia: management and patient prospects. 38
30028221 2018
45
Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy. 38
28617760 2018
46
Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis. 38
30354363 2018
47
[Rectal bleeding in a 60-year-old woman under anticoagulation and platelet aggregation inhibition]. 38
29671011 2018
48
Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices. 38
30354557 2018
49
A Case of Heyde Syndrome with Resolution of Gastrointestinal Bleeding Two Weeks After Aortic Valve Replacement. 38
30082678 2018
50
Ileal tubular adenoma as a cause of lower gastrointestinal bleeding in infants. 38
29900748 2018
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Variations for Angiodysplasia

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Expression for Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.
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Pathways for Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 37
Show member pathways
 12.46 VWF VEGFA FGF2 ANGPT2
2
HIF-1-alpha transcription factor network 1
11.34 VEGFA ENG
3
Endochondral Ossification 1
11.32 VEGFA FGF2
4
MECP2 and Associated Rett Syndrome 1
11.29 SST FGF2
5
Cell adhesion_Plasmin signaling 22
11.17 VEGFA FGF2
6
Differentiation Pathway 1
11.14 VEGFA FGF2
7
Integrins in angiogenesis 1
11.1 VEGFA FGF2
8
Vemurafenib Pathway, Pharmacodynamics 61
11.04 VEGFA FGF2
9
Photodynamic therapy-induced HIF-1 survival signaling 1
10.94 VEGFA ANGPT2
10
Angiogenesis (CST) 4
10.87 VWF FGF2 ENG ANGPT2
11
Glypican 1 network 1
10.67 VEGFA FGF2
12
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.55 ENG ANGPT2
13
Angiogenesis (WikiPathways) 1
10.34 VEGFA FGF2
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GO Terms for Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 VWF VEGFA SST SCT FGF2 ANGPT2
2 platelet alpha granule lumen GO:0031093 9.16 VWF VEGFA
3 extracellular space GO:0005615 9.1 VEGFA SST SCT FGF2 ENG ANGPT2

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.73 VEGFA ENG ACVRL1
2 positive regulation of MAP kinase activity GO:0043406 9.61 VEGFA FGF2
3 vasculogenesis GO:0001570 9.61 VEGFA ENG
4 response to hypoxia GO:0001666 9.61 VEGFA ANGPT2 ACVRL1
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.6 ENG ACVRL1
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.59 VEGFA FGF2
7 positive regulation of cell division GO:0051781 9.58 VEGFA FGF2
8 positive chemotaxis GO:0050918 9.58 VEGFA FGF2
9 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.57 VEGFA FGF2
10 positive regulation of BMP signaling pathway GO:0030513 9.55 ENG ACVRL1
11 sprouting angiogenesis GO:0002040 9.54 VEGFA ENG
12 blood vessel morphogenesis GO:0048514 9.52 ANGPT2 ACVRL1
13 positive regulation of sprouting angiogenesis GO:1903672 9.51 VEGFA FGF2
14 positive regulation of endothelial cell proliferation GO:0001938 9.5 VEGFA FGF2 ACVRL1
15 branching involved in blood vessel morphogenesis GO:0001569 9.49 VEGFA ENG
16 artery morphogenesis GO:0048844 9.48 VEGFA ENG
17 cell migration involved in sprouting angiogenesis GO:0002042 9.46 VEGFA FGF2
18 endocardial cushion morphogenesis GO:0003203 9.4 ENG ACVRL1
19 dorsal aorta morphogenesis GO:0035912 9.37 ENG ACVRL1
20 angiogenesis GO:0001525 9.35 VEGFA FGF2 ENG ANGPT2 ACVRL1
21 negative regulation of blood vessel endothelial cell migration GO:0043537 9.33 FGF2 ANGPT2 ACVRL1
22 endocardial cushion to mesenchymal transition GO:0090500 9.26 ENG ACVRL1
23 positive regulation of angiogenesis GO:0045766 9.02 VEGFA FGF2 ENG ANGPT2 ACVRL1

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFA FGF2
2 transforming growth factor beta binding GO:0050431 8.96 ENG ACVRL1
3 activin binding GO:0048185 8.62 ENG ACVRL1
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Sources for Angiodysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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