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MCID: ANG011
MIFTS: 48

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiodysplasia

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MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 55 44 15 73
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12
Angiodysplasia of Colon 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2494
MeSH 44 D016888
SNOMED-CT 68 71072006
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Summaries for Angiodysplasia

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Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to hereditary hemorrhagic telangiectasia and arteries, anomalies of. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endochondral Ossification. The drugs Iron and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 76 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

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Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 hereditary hemorrhagic telangiectasia 30.0 ACVRL1 ENG
2 arteries, anomalies of 29.7 VWF VEGFA ACVRL1
3 glucagonoma 29.7 SST SCT
4 hemangioma 29.6 VEGFA FGF2 ANGPT2
5 arteriovenous malformation 29.5 VEGFA ENG ACVRL1
6 portal hypertension 29.5 VWF VEGFA SST
7 vascular disease 29.1 VWF VEGFA FGF2 ENG ACVRL1
8 angiodysplasia of intestine 12.1
9 angioosteohypotrophic syndrome 11.4
10 nevada syndrome 11.1
11 von willebrand's disease 10.6
12 infiltrating angiolipoma 10.2 VWF VEGFA
13 lymphangiosarcoma 10.2 VWF VEGFA
14 angiosarcoma 10.2 VWF VEGFA
15 chronic myocardial ischemia 10.1 VEGFA FGF2
16 radiation proctitis 10.1 VEGFA FGF2
17 iron metabolism disease 10.1
18 angiomatous meningioma 10.1 VEGFA FGF2
19 vitreous disease 10.1 VEGFA FGF2
20 pyogenic granuloma 10.1 VEGFA ANGPT2
21 dupuytren contracture 10.1 VEGFA FGF2
22 background diabetic retinopathy 10.1 VEGFA ANGPT2
23 lipodermatosclerosis 10.1 VEGFA ANGPT2
24 space motion sickness 10.1 SCT FGF2
25 macular holes 10.1 VEGFA ANGPT2
26 bernard-soulier syndrome 10.1
27 aortic valve disease 2 10.1
28 glomeruloid hemangioma 10.1 VEGFA ENG
29 pericardial effusion 10.1 VEGFA FGF2
30 connective tissue cancer 10.1 VEGFA FGF2
31 epileptic encephalopathy, childhood-onset 10.1 VEGFA ANGPT2
32 corneal neovascularization 10.1 VEGFA FGF2
33 keratitis, hereditary 10.1 VEGFA FGF2
34 placental insufficiency 10.0 VEGFA ANGPT2
35 pulmonary arteriovenous malformation 10.0 ENG ACVRL1
36 heritable pulmonary arterial hypertension 10.0 ENG ACVRL1
37 varicose veins 10.0 VEGFA VWF
38 twin-to-twin transfusion syndrome 10.0 ENG ANGPT2
39 hepatopulmonary syndrome 10.0 VWF VEGFA ACVRL1
40 chronic mountain sickness 10.0 VEGFA SST
41 intermittent claudication 10.0 VWF VEGFA ANGPT2
42 insulinomatosis and diabetes mellitus 10.0 SST SCT
43 vipoma 10.0 SST SCT
44 carcinoid syndrome 10.0 VEGFA SST
45 duodenogastric reflux 10.0 SST SCT
46 hepatic vascular disease 10.0 VWF SST
47 pancreatic cholera 10.0 SST SCT
48 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.0 ENG ACVRL1
49 dumping syndrome 10.0 SST SCT
50 peripheral vascular disease 10.0 VEGFA VWF

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia
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Symptoms & Phenotypes for Angiodysplasia

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MGI Mouse Phenotypes related to Angiodysplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ACVRL1 ANGPT2 ENG FGF2 VEGFA VWF
2 digestive/alimentary MP:0005381 9.73 ACVRL1 ANGPT2 ENG SST VEGFA VWF
3 homeostasis/metabolism MP:0005376 9.7 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
4 mortality/aging MP:0010768 9.5 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
5 nervous system MP:0003631 9.1 ACVRL1 ENG FGF2 SST VEGFA VWF
Sources

Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3,Not Applicable 7439-89-6 23925
2
Somatostatin Approved, Investigational Phase 2, Phase 3 51110-01-1, 38916-34-6 53481605
3
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
4 Proton Pump Inhibitors Phase 2, Phase 3
5 Gastrointestinal Agents Phase 2, Phase 3
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7
Pasireotide Approved Phase 2 396091-73-9 9941444
8 Hormones Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Hormone Antagonists Phase 2
11 Anti-Infective Agents Phase 2,Phase 1
12 Anti-Bacterial Agents Phase 2,Phase 1
13 Immunologic Factors Phase 2,Phase 1
14 Angiogenesis Modulating Agents Phase 2,Phase 1
15 Angiogenesis Inhibitors Phase 2,Phase 1
16 Immunosuppressive Agents Phase 2,Phase 1
17 Pomalidomide Approved Phase 1 19171-19-8
18
Infliximab Approved Not Applicable 170277-31-3
19
Warfarin Approved 81-81-2 6691 54678486
20
Serine Approved, Nutraceutical 56-45-1 5951
21 Cola Not Applicable
22 Hemostatics
23 Pharmaceutical Solutions Not Applicable
24
protease inhibitors
25 Anticoagulants
26 Antithrombins
27 Antithrombin III
28 HIV Protease Inhibitors
29 Serine Proteinase Inhibitors
30 Dabigatran

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
2 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
3 Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
4 Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
6 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
7 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
8 Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
9 Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study Recruiting NCT02287558 Phase 1 Pomalidomide
10 Prophylactic Elective Clipping of Colonic Diverticula Unknown status NCT02094456 Not Applicable
11 Study of Hemospray for Lower Gastrointestinal Hemorrhage Completed NCT02099435
12 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
13 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule Completed NCT01820182 Not Applicable
14 Efficacy of Wireless Capsule Endoscopy and CT Enterography in Obscure Gastrointestinal Bleeding Completed NCT02219568 Not Applicable
15 Fecal Screening Assay for Taiwanese Population Completed NCT01341197
16 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Completed NCT00694954 Not Applicable
17 Effect of Water Exchange Method on Single-balloon Enteroscopy Completed NCT01942863 Not Applicable
18 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
19 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
20 Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE) Recruiting NCT03525366
21 MSCT Angiography in Bleeding Not yet recruiting NCT03464513 Not Applicable
22 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395 Not Applicable

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

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Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

41
Colon, Small Intestine, Liver, Lung, Kidney, Brain, Pancreas
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Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50) (show all 478)
# Title Authors Year
1
Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease. ( 29446520 )
2018
2
Successful Treatment of Recurrent Gastrointestinal Bleeding due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide - Two Birds with One Stone. ( 29911985 )
2018
3
Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon. ( 29336404 )
2018
4
Polypoid angiodysplasia mimicking diverticular disease. ( 29884485 )
2018
5
Fleeting Angiodysplasia. ( 29998169 )
2018
6
Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018. ( 30009379 )
2018
7
An overview of angiodysplasia: management and patient prospects. ( 30028221 )
2018
8
Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese. ( 30348493 )
2018
9
Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices. ( 30354557 )
2018
10
Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. ( 30485828 )
2018
11
Colonic angiodysplasia on CT colonography: case report and characteristic imaging findings. ( 29484051 )
2017
12
Ileal angiodysplasia presentation as a bowel obstruction: A case report. ( 28892784 )
2017
13
Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia. ( 28868182 )
2017
14
Role of Octreotide in Pediatric Gastrointestinal Bleeding Secondary to Angiodysplasia in Children with Right Heart Failure. ( 28614113 )
2017
15
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding. ( 29092972 )
2017
16
Continuous-Flow LVAD Support Causes a Distinct Form of Intestinal Angiodysplasia. ( 28729354 )
2017
17
Review on gastrointestinal angiodysplasia throughout the gastrointestinal tract. ( 28395783 )
2017
18
Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science. ( 28476066 )
2017
19
Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort. ( 28552982 )
2017
20
Intractable anemia due to extensive refractory angiodysplasia of the small intestine stabilized by an anti-angiogenic agent. ( 28062159 )
2017
21
Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann's Thrombasthenia. ( 28670433 )
2017
22
Automated angiodysplasia detection from wireless capsule endoscopy. ( 29060568 )
2017
23
Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy. ( 28617760 )
2017
24
von Willebrand disease and extra-intestinal angiodysplasia. ( 28574209 )
2017
25
Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement. ( 28824071 )
2017
26
Multiple angiodysplasia diagnosed by capsule endoscopy. ( 28280628 )
2017
27
Gastrointestinal Angiodysplasia: Diagnosis and Management. ( 27908518 )
2017
28
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells. ( 28003433 )
2017
29
Hemorrhagic angiodysplasia of the digestive tract: pathogenesis, diagnosis, and management. ( 28554655 )
2017
30
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog. ( 26885595 )
2016
31
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. ( 27480046 )
2016
32
Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon. ( 27340585 )
2016
33
Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study. ( 27424692 )
2016
34
Hematochezia due to Angiodysplasia of the Appendix. ( 27437394 )
2016
35
In-hospital weekend outcomes in patients diagnosed with bleedingA gastroduodenal angiodysplasia: a population-based study,A 2000 toA 2011. ( 26972023 )
2016
36
Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage. ( 26791122 )
2016
37
Segmentation of angiodysplasia lesions in WCE images using a MAP approach with Markov Random Fields. ( 28268536 )
2016
38
Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient. ( 27659936 )
2016
39
Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia. ( 27207426 )
2016
40
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
41
Hemobilia from Biliary Angiodysplasia Diagnosed with Cholangioscopy. ( 27807584 )
2016
42
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. ( 26828247 )
2016
43
Gastrointestinal angiodysplasia is associated with significant gastrointestinal bleeding in patients with continuous left ventricular assist devices. ( 27004257 )
2016
44
Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. ( 27596107 )
2016
45
Multiple Polypoid Angiodysplasia with Obscure Overt Bleeding. ( 26855931 )
2016
46
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial. ( 26966525 )
2016
47
Severe aortic stenosis, critical coronary artery disease, and transfusion-dependent angiodysplasia - A management conundrum. ( 30546614 )
2016
48
Use of polymethylmethacrylate in treatment of arteriovenous angiodysplasia with bone lesions. ( 26355937 )
2015
49
Thalidomide for treatment of gastrointestinal angiodysplasia in patients with left ventricular assist devices: case series and treatment protocol. ( 25447569 )
2015
50
Argon plasma coagulation in the management of symptomatic gastrointestinal angiodysplasia: experience in 69 consecutive patients. ( 26895122 )
2015
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Variations for Angiodysplasia

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Expression for Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.
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Pathways for Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 37
Show member pathways
 12.46 ANGPT2 FGF2 VEGFA VWF
2
Endochondral Ossification 1
11.34 FGF2 VEGFA
3
HIF-1-alpha transcription factor network 1
11.32 ENG VEGFA
4
MECP2 and Associated Rett Syndrome 1
11.29 FGF2 SST
5
Cell adhesion_Plasmin signaling 22
11.17 FGF2 VEGFA
6
Differentiation Pathway 1
11.14 FGF2 VEGFA
7
Integrins in angiogenesis 1
11.1 FGF2 VEGFA
8
Vemurafenib Pathway, Pharmacodynamics 61
11.03 FGF2 VEGFA
9
Photodynamic therapy-induced HIF-1 survival signaling 1
10.94 ANGPT2 VEGFA
10
Angiogenesis (CST) 4
10.87 ANGPT2 ENG FGF2 VWF
11
Glypican 1 network 1
10.67 FGF2 VEGFA
12
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.55 ANGPT2 ENG
13
Angiogenesis (WikiPathways) 1
10.34 FGF2 VEGFA
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GO Terms for Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT2 FGF2 SCT SST VEGFA VWF
2 platelet alpha granule lumen GO:0031093 9.16 VEGFA VWF
3 extracellular space GO:0005615 9.1 ANGPT2 ENG FGF2 SCT SST VEGFA

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.74 ACVRL1 ENG VEGFA
2 regulation of signaling receptor activity GO:0010469 9.71 FGF2 SCT SST VEGFA
3 response to hypoxia GO:0001666 9.63 ACVRL1 ANGPT2 VEGFA
4 positive regulation of MAP kinase activity GO:0043406 9.62 FGF2 VEGFA
5 vasculogenesis GO:0001570 9.61 ENG VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 FGF2 VEGFA
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.6 ACVRL1 ENG
8 positive chemotaxis GO:0050918 9.59 FGF2 VEGFA
9 positive regulation of cell division GO:0051781 9.58 FGF2 VEGFA
10 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 FGF2 VEGFA
11 positive regulation of BMP signaling pathway GO:0030513 9.56 ACVRL1 ENG
12 sprouting angiogenesis GO:0002040 9.55 ENG VEGFA
13 blood vessel morphogenesis GO:0048514 9.54 ACVRL1 ANGPT2
14 branching involved in blood vessel morphogenesis GO:0001569 9.52 ENG VEGFA
15 positive regulation of sprouting angiogenesis GO:1903672 9.51 FGF2 VEGFA
16 positive regulation of endothelial cell proliferation GO:0001938 9.5 ACVRL1 FGF2 VEGFA
17 artery morphogenesis GO:0048844 9.49 ENG VEGFA
18 cell migration involved in sprouting angiogenesis GO:0002042 9.48 FGF2 VEGFA
19 endocardial cushion morphogenesis GO:0003203 9.43 ACVRL1 ENG
20 dorsal aorta morphogenesis GO:0035912 9.37 ACVRL1 ENG
21 angiogenesis GO:0001525 9.35 ACVRL1 ANGPT2 ENG FGF2 VEGFA
22 negative regulation of blood vessel endothelial cell migration GO:0043537 9.33 ACVRL1 ANGPT2 FGF2
23 endocardial cushion to mesenchymal transition GO:0090500 9.26 ACVRL1 ENG
24 positive regulation of angiogenesis GO:0045766 9.02 ACVRL1 ANGPT2 ENG FGF2 VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 transforming growth factor beta binding GO:0050431 8.96 ACVRL1 ENG
3 activin binding GO:0048185 8.62 ACVRL1 ENG
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Sources for Angiodysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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