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MCID: ANG011
MIFTS: 48

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiodysplasia

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MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 56 45 15 74
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12
Angiodysplasia of Colon 74

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2494
MeSH 45 D016888
SNOMED-CT 69 71072006
ICD10 34 K55.2
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Summaries for Angiodysplasia

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Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to hereditary hemorrhagic telangiectasia and telangiectasis. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endochondral Ossification. The drugs Iron and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and liver, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 77 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

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Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 hereditary hemorrhagic telangiectasia 30.2 ACVRL1 ENG
2 telangiectasis 30.0 ACVRL1 ENG VEGFA
3 varicose veins 30.0 VEGFA VWF
4 arteries, anomalies of 29.7 ACVRL1 VEGFA VWF
5 arteriovenous malformation 29.7 ACVRL1 ENG VEGFA
6 glucagonoma 29.7 SCT SST
7 hemangioma 29.6 ANGPT2 FGF2 VEGFA
8 portal hypertension 29.5 SST VEGFA VWF
9 vascular disease 28.8 ACVRL1 ENG FGF2 VEGFA VWF
10 angiodysplasia of intestine 12.1
11 angioosteohypotrophic syndrome 11.4
12 telangiectasia, hereditary hemorrhagic, type 4 11.2
13 nevada syndrome 11.1
14 von willebrand's disease 10.6
15 infiltrating angiolipoma 10.3 VEGFA VWF
16 lymphangiosarcoma 10.2 VEGFA VWF
17 angiosarcoma 10.2 VEGFA VWF
18 chronic myocardial ischemia 10.2 FGF2 VEGFA
19 radiation proctitis 10.2 FGF2 VEGFA
20 poems syndrome 10.2 FGF2 VEGFA
21 angiomatous meningioma 10.2 FGF2 VEGFA
22 pyogenic granuloma 10.2 ANGPT2 VEGFA
23 vitreous disease 10.2 FGF2 VEGFA
24 dupuytren contracture 10.2 FGF2 VEGFA
25 background diabetic retinopathy 10.2 ANGPT2 VEGFA
26 lipodermatosclerosis 10.2 ANGPT2 VEGFA
27 iron metabolism disease 10.2
28 active peptic ulcer disease 10.2
29 space motion sickness 10.2 FGF2 SCT
30 macular holes 10.2 ANGPT2 VEGFA
31 glomeruloid hemangioma 10.1 ENG VEGFA
32 pericardial effusion 10.1 FGF2 VEGFA
33 breast carcinoma in situ 10.1 FGF2 VEGFA
34 bernard-soulier syndrome 10.1
35 aortic valve disease 2 10.1
36 acquired von willebrand syndrome 10.1
37 epileptic encephalopathy, childhood-onset 10.1 ANGPT2 VEGFA
38 corneal neovascularization 10.1 FGF2 VEGFA
39 connective tissue cancer 10.1 FGF2 VEGFA
40 keratitis, hereditary 10.1 FGF2 VEGFA
41 pulmonary arteriovenous malformation 10.1 ACVRL1 ENG
42 meckel diverticulum 10.1
43 deficiency anemia 10.1
44 placental insufficiency 10.0 ANGPT2 VEGFA
45 heritable pulmonary arterial hypertension 10.0 ACVRL1 ENG
46 twin-to-twin transfusion syndrome 10.0 ANGPT2 ENG
47 chronic mountain sickness 10.0 SST VEGFA
48 hepatopulmonary syndrome 10.0 ACVRL1 VEGFA VWF
49 intermittent claudication 10.0 ANGPT2 VEGFA VWF
50 insulinomatosis and diabetes mellitus 10.0 SCT SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia
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Symptoms & Phenotypes for Angiodysplasia

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MGI Mouse Phenotypes related to Angiodysplasia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ACVRL1 ANGPT2 ENG FGF2 VEGFA VWF
2 digestive/alimentary MP:0005381 9.73 ACVRL1 ANGPT2 ENG SST VEGFA VWF
3 homeostasis/metabolism MP:0005376 9.7 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
4 mortality/aging MP:0010768 9.5 ACVRL1 ANGPT2 ENG FGF2 SST VEGFA
5 nervous system MP:0003631 9.1 ACVRL1 ENG FGF2 SST VEGFA VWF
Sources

Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 2, Phase 3,Not Applicable 7439-89-6, 15438-31-0 27284 23925
2
Somatostatin Approved, Investigational Phase 2, Phase 3 38916-34-6, 51110-01-1 53481605
3
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 6400441 383414
4 Proton Pump Inhibitors Phase 2, Phase 3
5 Antineoplastic Agents, Hormonal Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7
Pasireotide Approved Phase 2 396091-73-9 9941444
8
Ferrous succinate Approved Phase 2 10030-90-7
9 Hormones Phase 2
10 Hormone Antagonists Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
12 Immunosuppressive Agents Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 2,Phase 1
14 Angiogenesis Inhibitors Phase 2,Phase 1
15 Angiogenesis Modulating Agents Phase 2,Phase 1
16 Anti-Infective Agents Phase 2,Phase 1
17 Hematinics Phase 2
18 Immunologic Factors Phase 2,Phase 1
19
Pomalidomide Approved Phase 1 19171-19-8
20
Infliximab Approved Not Applicable 170277-31-3
21
Warfarin Approved 81-81-2 54678486 6691
22
Serine Approved, Nutraceutical 56-45-1 5951
23
Dabigatran Investigational 211914-51-1
24 Cola Not Applicable
25 Hemostatics
26 Pharmaceutical Solutions Not Applicable
27
protease inhibitors
28 Anticoagulants
29 HIV Protease Inhibitors
30 Antithrombin III
31 Antithrombins
32 Serine Proteinase Inhibitors

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
2 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
3 Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
4 Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
6 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
7 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
8 Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
9 Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study Recruiting NCT02287558 Phase 1 Pomalidomide
10 Prophylactic Elective Clipping of Colonic Diverticula Unknown status NCT02094456 Not Applicable
11 Study of Hemospray for Lower Gastrointestinal Hemorrhage Completed NCT02099435
12 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
13 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule Completed NCT01820182 Not Applicable
14 Efficacy of Wireless Capsule Endoscopy and CT Enterography in Obscure Gastrointestinal Bleeding Completed NCT02219568 Not Applicable
15 Fecal Screening Assay for Taiwanese Population Completed NCT01341197
16 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Completed NCT00694954 Not Applicable
17 Effect of Water Exchange Method on Single-balloon Enteroscopy Completed NCT01942863 Not Applicable
18 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
19 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
20 Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE) Recruiting NCT03525366
21 MSCT Angiography in Bleeding Not yet recruiting NCT03464513 Not Applicable
22 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395 Not Applicable

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

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Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

42
Colon, Small Intestine, Liver, Lung, Kidney, Testes, Breast
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Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50) (show all 480)
# Title Authors Year
1
Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese. ( 30348493 )
2019
2
Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. ( 30485828 )
2019
3
Role of Octreotide in Pediatric Gastrointestinal Bleeding Secondary to Angiodysplasia in Children With Right Heart Failure. ( 28614113 )
2018
4
Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy. ( 28617760 )
2018
5
Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon. ( 29336404 )
2018
6
Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease. ( 29446520 )
2018
7
Polypoid angiodysplasia mimicking diverticular disease. ( 29884485 )
2018
8
Successful Treatment of Recurrent Gastrointestinal Bleeding Due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide: Two Birds with One Stone ( 29911985 )
2018
9
Fleeting Angiodysplasia. ( 29998169 )
2018
10
Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018. ( 30009379 )
2018
11
An overview of angiodysplasia: management and patient prospects. ( 30028221 )
2018
12
Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices. ( 30354557 )
2018
13
Gastric Cancer, Hemophilia A and Angiodysplasia - An Unreported Association with Clinical Implications in a Patient with Digestive Hemorrhage. ( 30596373 )
2018
14
Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract. ( 30864370 )
2018
15
Gastrointestinal Angiodysplasia: Diagnosis and Management. ( 27908518 )
2017
16
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 in vascular endothelial cells. ( 28003433 )
2017
17
Intractable anemia due to extensive refractory angiodysplasia of the small intestine stabilized by an anti-angiogenic agent. ( 28062159 )
2017
18
Multiple angiodysplasia diagnosed by capsule endoscopy. ( 28280628 )
2017
19
Review on gastrointestinal angiodysplasia throughout the gastrointestinal tract. ( 28395783 )
2017
20
Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science. ( 28476066 )
2017
21
Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort. ( 28552982 )
2017
22
Hemorrhagic angiodysplasia of the digestive tract: pathogenesis, diagnosis, and management. ( 28554655 )
2017
23
von Willebrand disease and extra-intestinal angiodysplasia. ( 28574209 )
2017
24
Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann's Thrombasthenia. ( 28670433 )
2017
25
Continuous-Flow LVAD Support Causes a Distinct Form of Intestinal Angiodysplasia. ( 28729354 )
2017
26
Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement. ( 28824071 )
2017
27
Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia. ( 28868182 )
2017
28
Ileal angiodysplasia presentation as a bowel obstruction: A case report. ( 28892784 )
2017
29
Automated angiodysplasia detection from wireless capsule endoscopy. ( 29060568 )
2017
30
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding. ( 29092972 )
2017
31
Colonic angiodysplasia on CT colonography: case report and characteristic imaging findings. ( 29484051 )
2017
32
Hemobilia from Biliary Angiodysplasia Diagnosed with Cholangioscopy. ( 27807584 )
2016
33
Segmentation of angiodysplasia lesions in WCE images using a MAP approach with Markov Random Fields. ( 28268536 )
2016
34
The natural history of small bowel angiodysplasia. ( 26540240 )
2016
35
Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage. ( 26791122 )
2016
36
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. ( 26828247 )
2016
37
Multiple Polypoid Angiodysplasia with Obscure Overt Bleeding. ( 26855931 )
2016
38
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog. ( 26885595 )
2016
39
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial. ( 26966525 )
2016
40
In-hospital weekend outcomes in patients diagnosed with bleeding gastroduodenal angiodysplasia: a population-based study, 2000 to 2011. ( 26972023 )
2016
41
Gastrointestinal angiodysplasia is associated with significant gastrointestinal bleeding in patients with continuous left ventricular assist devices. ( 27004257 )
2016
42
Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia. ( 27207426 )
2016
43
Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon. ( 27340585 )
2016
44
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
45
Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study. ( 27424692 )
2016
46
Hematochezia due to Angiodysplasia of the Appendix. ( 27437394 )
2016
47
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. ( 27480046 )
2016
48
Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. ( 27596107 )
2016
49
Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient. ( 27659936 )
2016
50
Severe aortic stenosis, critical coronary artery disease, and transfusion-dependent angiodysplasia - A management conundrum. ( 30546614 )
2016
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Variations for Angiodysplasia

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Expression for Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.
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Pathways for Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 38
Show member pathways
 12.46 ANGPT2 FGF2 VEGFA VWF
2
Endochondral Ossification 1
11.34 FGF2 VEGFA
3
HIF-1-alpha transcription factor network 1
11.32 ENG VEGFA
4
MECP2 and Associated Rett Syndrome 1
11.29 FGF2 SST
5
Cell adhesion_Plasmin signaling 23
11.17 FGF2 VEGFA
6
Differentiation Pathway 1
11.14 FGF2 VEGFA
7
Integrins in angiogenesis 1
11.1 FGF2 VEGFA
8
Vemurafenib Pathway, Pharmacodynamics 62
11.04 FGF2 VEGFA
9
Photodynamic therapy-induced HIF-1 survival signaling 1
10.94 ANGPT2 VEGFA
10
Angiogenesis (CST) 4
10.87 ANGPT2 ENG FGF2 VWF
11
Glypican 1 network 1
10.67 FGF2 VEGFA
12
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.55 ANGPT2 ENG
13
Angiogenesis (WikiPathways) 1
10.34 FGF2 VEGFA
Sources

GO Terms for Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ANGPT2 FGF2 SCT SST VEGFA VWF
2 platelet alpha granule lumen GO:0031093 9.16 VEGFA VWF
3 extracellular space GO:0005615 9.1 ANGPT2 ENG FGF2 SCT SST VEGFA

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.74 ACVRL1 ENG VEGFA
2 regulation of signaling receptor activity GO:0010469 9.71 FGF2 SCT SST VEGFA
3 response to hypoxia GO:0001666 9.63 ACVRL1 ANGPT2 VEGFA
4 positive regulation of MAP kinase activity GO:0043406 9.62 FGF2 VEGFA
5 vasculogenesis GO:0001570 9.61 ENG VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 FGF2 VEGFA
7 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.6 ACVRL1 ENG
8 positive chemotaxis GO:0050918 9.59 FGF2 VEGFA
9 positive regulation of cell division GO:0051781 9.58 FGF2 VEGFA
10 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 FGF2 VEGFA
11 positive regulation of BMP signaling pathway GO:0030513 9.56 ACVRL1 ENG
12 sprouting angiogenesis GO:0002040 9.55 ENG VEGFA
13 blood vessel morphogenesis GO:0048514 9.54 ACVRL1 ANGPT2
14 branching involved in blood vessel morphogenesis GO:0001569 9.52 ENG VEGFA
15 positive regulation of sprouting angiogenesis GO:1903672 9.51 FGF2 VEGFA
16 positive regulation of endothelial cell proliferation GO:0001938 9.5 ACVRL1 FGF2 VEGFA
17 artery morphogenesis GO:0048844 9.49 ENG VEGFA
18 cell migration involved in sprouting angiogenesis GO:0002042 9.48 FGF2 VEGFA
19 endocardial cushion morphogenesis GO:0003203 9.43 ACVRL1 ENG
20 dorsal aorta morphogenesis GO:0035912 9.37 ACVRL1 ENG
21 angiogenesis GO:0001525 9.35 ACVRL1 ANGPT2 ENG FGF2 VEGFA
22 negative regulation of blood vessel endothelial cell migration GO:0043537 9.33 ACVRL1 ANGPT2 FGF2
23 endocardial cushion to mesenchymal transition GO:0090500 9.26 ACVRL1 ENG
24 positive regulation of angiogenesis GO:0045766 9.02 ACVRL1 ANGPT2 ENG FGF2 VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 transforming growth factor beta binding GO:0050431 8.96 ACVRL1 ENG
3 activin binding GO:0048185 8.62 ACVRL1 ENG
Sources

Sources for Angiodysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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