MCID: ANG011
MIFTS: 47

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Angiodysplasia

MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 55 44 15 73
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12
Angiodysplasia of Colon 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2494
ICD9CM 35 537.83
MeSH 44 D016888
SNOMED-CT 68 71072006

Summaries for Angiodysplasia

Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of stomach and duodenum with hemorrhage, is related to pulmonary arteriovenous malformation and hereditary hemorrhagic telangiectasia. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Endochondral Ossification and HIF-1-alpha transcription factor network. The drugs Iron and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and testes, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 76 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

Related Diseases for Angiodysplasia

Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 pulmonary arteriovenous malformation 29.6 ACVRL1 ENG
2 hereditary hemorrhagic telangiectasia 29.4 ACVRL1 ENG
3 glucagonoma 29.4 SCT SST
4 arteriovenous malformation 29.2 ACVRL1 ENG VEGFA
5 portal hypertension 29.1 SST VEGFA VWF
6 vascular disease 27.5 ACVRL1 ENG FGF2 VEGFA VWF
7 angiodysplasia of intestine 11.9
8 angioosteohypotrophic syndrome 11.2
9 nevada syndrome 10.9
10 infiltrating angiolipoma 10.6 VEGFA VWF
11 critical limb ischemia 10.6 VEGFA VWF
12 lymphangiosarcoma 10.5 VEGFA VWF
13 hepatopulmonary syndrome 10.4 VEGFA VWF
14 chronic myocardial ischemia 10.4 FGF2 VEGFA
15 radiation proctitis 10.4 FGF2 VEGFA
16 intermittent claudication 10.4 VEGFA VWF
17 von willebrand's disease 10.4
18 angiomatous meningioma 10.4 FGF2 VEGFA
19 dupuytren contracture 10.4 FGF2 VEGFA
20 vitreous disease 10.4 FGF2 VEGFA
21 angiosarcoma 10.3 VEGFA VWF
22 pericardial effusion 10.3 FGF2 VEGFA
23 glomeruloid hemangioma 10.3 ENG VEGFA
24 connective tissue cancer 10.2 FGF2 VEGFA
25 corneal neovascularization 10.2 FGF2 VEGFA
26 keratitis, hereditary 10.2 FGF2 VEGFA
27 telangiectasia, hereditary hemorrhagic, type 1 10.1 ACVRL1 ENG
28 pulmonary hypertension, primary, 1 10.1 ACVRL1 ENG
29 limb ischemia 10.1 FGF2 VEGFA VWF
30 heritable pulmonary arterial hypertension 10.1 ACVRL1 ENG
31 chronic mountain sickness 10.0 SST VEGFA
32 pancreatic gastrinoma 10.0 SCT SST
33 arteries, anomalies of 10.0 ACVRL1 VEGFA VWF
34 varicose veins 10.0 VEGFA VWF
35 iron metabolism disease 10.0
36 duodenitis 10.0
37 hyperinsulinemic hypoglycemia, familial, 2 10.0 SCT SST
38 endometrial adenocarcinoma 10.0 FGF2 VEGFA
39 carcinoid syndrome 9.9 SST VEGFA
40 duodenogastric reflux 9.9 SCT SST
41 vipoma 9.9 SCT SST
42 pancreatic cholera 9.9 SCT SST
43 dumping syndrome 9.9 SCT SST
44 duodenal gastrinoma 9.9 SCT SST
45 aortic valve disease 1 9.9
46 bernard-soulier syndrome 9.9
47 aortic valve disease 2 9.9
48 mucositis 9.9
49 endotheliitis 9.9
50 zollinger-ellison syndrome 9.9 SCT SST

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia

Symptoms & Phenotypes for Angiodysplasia

MGI Mouse Phenotypes related to Angiodysplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ACVRL1 CADPS ENG FGF2 SST VEGFA
2 digestive/alimentary MP:0005381 9.65 ACVRL1 ENG SST VEGFA VWF
3 mortality/aging MP:0010768 9.5 ACVRL1 CADPS ENG FGF2 SST VEGFA
4 nervous system MP:0003631 9.17 ENG FGF2 SST VEGFA VWF ACVRL1

Drugs & Therapeutics for Angiodysplasia

Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3,Not Applicable 7439-89-6 23925
2
Somatostatin Approved, Investigational Phase 2, Phase 3 38916-34-6, 51110-01-1 53481605
3
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
4 Proton Pump Inhibitors Phase 2, Phase 3
5 Antineoplastic Agents, Hormonal Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7 Hormone Antagonists Phase 2
8 Hormones Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Angiogenesis Inhibitors Phase 2,Phase 1
11 Angiogenesis Modulating Agents Phase 2,Phase 1
12 Anti-Bacterial Agents Phase 2,Phase 1
13 Anti-Infective Agents Phase 2,Phase 1
14 Immunosuppressive Agents Phase 2,Phase 1
15 Pomalidomide Approved Phase 1 19171-19-8
16
Infliximab Approved Not Applicable 170277-31-3
17
Warfarin Approved 81-81-2 6691 54678486
18
Serine Approved, Nutraceutical 56-45-1 5951
19 Hemostatics
20 Pharmaceutical Solutions Not Applicable
21 Anticoagulants
22 Antithrombin III
23 Antithrombins
24 Dabigatran
25 HIV Protease Inhibitors
26
protease inhibitors
27 Serine Proteinase Inhibitors
28 Cola Nutraceutical Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Cyrotherapy vs. APC in GAVE Completed NCT00587405 Phase 2, Phase 3
2 Endoscopic Band Ligation Versus Argon Plasma Coagulation for the Treatment of Gastric Antral Vascular Ectasia: a Randomized Clinical Trial Completed NCT01601639 Phase 3
3 Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
4 Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation Completed NCT00964496 Phase 2 Thalidomide;Iron
6 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
7 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
8 Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
9 Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study Recruiting NCT02287558 Phase 1 Pomalidomide
10 Prophylactic Elective Clipping of Colonic Diverticula Unknown status NCT02094456 Not Applicable
11 Study of Hemospray for Lower Gastrointestinal Hemorrhage Completed NCT02099435
12 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
13 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule Completed NCT01820182 Not Applicable
14 Efficacy of Wireless Capsule Endoscopy and CT Enterography in Obscure Gastrointestinal Bleeding Completed NCT02219568 Not Applicable
15 Fecal Screening Assay for Taiwanese Population Completed NCT01341197
16 Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding Completed NCT00694954 Not Applicable
17 Effect of Water Exchange Method on Single-balloon Enteroscopy Completed NCT01942863 Not Applicable
18 The Comparative Safety and Effectiveness of Warfarin and Dabigatran Prescribed in the Non-valvular Atrial Fibrillation Population With Humana Healthcare Coverage Completed NCT02061748 Observational
19 Usefulness of Fecal Immunochemical Test in Iron Deficiency Anemia (IDAFIT) Recruiting NCT02792023 Not Applicable
20 Prospective Evaluation Of Outcomes For Patients Undergoing Radiofrequency Ablation (RFA) Using HALO Ultra Device For Gastric Antral Vascular Ectasia (GAVE) Recruiting NCT03525366
21 MSCT Angiography in Bleeding Not yet recruiting NCT03464513 Not Applicable
22 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395 Not Applicable

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

Genetic Tests for Angiodysplasia

Anatomical Context for Angiodysplasia

MalaCards organs/tissues related to Angiodysplasia:

41
Colon, Small Intestine, Testes, Endothelial, Liver, Lung, Appendix

Publications for Angiodysplasia

Articles related to Angiodysplasia:

(show top 50) (show all 464)
# Title Authors Year
1
Lenalidomide as a novel therapy for gastrointestinal angiodysplasia in von Willebrand disease. ( 29446520 )
2018
2
Successful Treatment of Recurrent Gastrointestinal Bleeding due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide - Two Birds with One Stone. ( 29911985 )
2018
3
Role of transesophageal echocardiography during left atrial appendage occlusion device closure in a patient with non-valvular atrial fibrillation and angiodysplasia of the colon. ( 29336404 )
2018
4
Polypoid angiodysplasia mimicking diverticular disease. ( 29884485 )
2018
5
Colonic angiodysplasia on CT colonography: case report and characteristic imaging findings. ( 29484051 )
2017
6
Ileal angiodysplasia presentation as a bowel obstruction: A case report. ( 28892784 )
2017
7
Assessment of serum angiogenic factors as a diagnostic aid for small bowel angiodysplasia in patients with obscure gastrointestinal bleeding and anaemia. ( 28868182 )
2017
8
Role of Octreotide in Pediatric Gastrointestinal Bleeding Secondary to Angiodysplasia in Children with Right Heart Failure. ( 28614113 )
2017
9
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding. ( 29092972 )
2017
10
Continuous-Flow LVAD Support Causes a Distinct Form of Intestinal Angiodysplasia. ( 28729354 )
2017
11
Review on gastrointestinal angiodysplasia throughout the gastrointestinal tract. ( 28395783 )
2017
12
Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science. ( 28476066 )
2017
13
Decreased health-related quality of life in angiodysplasia patients: A cross-sectional cohort. ( 28552982 )
2017
14
Intractable anemia due to extensive refractory angiodysplasia of the small intestine stabilized by an anti-angiogenic agent. ( 28062159 )
2017
15
Thalidomide for the Treatment of Gastrointestinal Bleeding Due to Angiodysplasia in a Patient with Glanzmann's Thrombasthenia. ( 28670433 )
2017
16
Automated angiodysplasia detection from wireless capsule endoscopy. ( 29060568 )
2017
17
Nonisolated Small Bowel Gastrointestinal Angiodysplasias are Associated With Higher Rebleeding Rates When Compared With Isolated Small Bowel Gastrointestinal Angiodysplasia on Video Capsule Endoscopy. ( 28617760 )
2017
18
von Willebrand disease and extra-intestinal angiodysplasia. ( 28574209 )
2017
19
Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement. ( 28824071 )
2017
20
Multiple angiodysplasia diagnosed by capsule endoscopy. ( 28280628 )
2017
21
Gastrointestinal Angiodysplasia: Diagnosis and Management. ( 27908518 )
2017
22
Hemorrhagic angiodysplasia of the digestive tract: pathogenesis, diagnosis, and management. ( 28554655 )
2017
23
Use of endoscopic-assisted argon plasma coagulation for the treatment of colonic vascular ectasia (angiodysplasia) in an adult dog. ( 26885595 )
2016
24
Popliteal Artery Entrapment and Fibular Angiodysplasia in Siblings. ( 27480046 )
2016
25
Colonic Angiodysplasia with a Huge Submucosal Hematoma in the Sigmoid Colon. ( 27340585 )
2016
26
Gastrointestinal bleeding due to angiodysplasia in patients on hemodialysis: A single-center study. ( 27424692 )
2016
27
Hematochezia due to Angiodysplasia of the Appendix. ( 27437394 )
2016
28
In-hospital weekend outcomes in patients diagnosed with bleedingA gastroduodenal angiodysplasia: a population-based study,A 2000 toA 2011. ( 26972023 )
2016
29
Thalidomide for the treatment of angiodysplasia in a patient with acute upper gastrointestinal haemorrhage. ( 26791122 )
2016
30
Segmentation of angiodysplasia lesions in WCE images using a MAP approach with Markov Random Fields. ( 28268536 )
2016
31
Hemodialysis Switch Improved Colonic Angiodysplasia in a Peritoneal Dialysis Patient. ( 27659936 )
2016
32
Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia. ( 27207426 )
2016
33
Is there a role for antiangiogenic therapy, bevacizumab, in the treatment of recurrent digestive bleeding due to angiodysplasia in Glanzmann's thrombasthenia? ( 27352634 )
2016
34
Hemobilia from Biliary Angiodysplasia Diagnosed with Cholangioscopy. ( 27807584 )
2016
35
Analysis of risk factor and clinical characteristics of angiodysplasia presenting as upper gastrointestinal bleeding. ( 26828247 )
2016
36
Gastrointestinal angiodysplasia is associated with significant gastrointestinal bleeding in patients with continuous left ventricular assist devices. ( 27004257 )
2016
37
Risk factors for active bleeding from colonic angiodysplasia confirmed by colonoscopic observation. ( 27596107 )
2016
38
Multiple Polypoid Angiodysplasia with Obscure Overt Bleeding. ( 26855931 )
2016
39
Long-acting somatostatin analogues provide significant beneficial effect in patients with refractory small bowel angiodysplasia: Results from a proof of concept open label mono-centre trial. ( 26966525 )
2016
40
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells. ( 28003433 )
2016
41
Use of polymethylmethacrylate in treatment of arteriovenous angiodysplasia with bone lesions. ( 26355937 )
2015
42
Thalidomide for treatment of gastrointestinal angiodysplasia in patients with left ventricular assist devices: case series and treatment protocol. ( 25447569 )
2015
43
Argon plasma coagulation in the management of symptomatic gastrointestinal angiodysplasia: experience in 69 consecutive patients. ( 26895122 )
2015
44
Thalidomide in angiodysplasia-related bleeding. ( 26332623 )
2015
45
Jejunal angiodysplasia causing recurrent gastrointestinal bleeding presenting as severe anaemia and melena. ( 26567241 )
2015
46
Angiodysplasia: an unusual case of gastrointestinal bleeding. ( 26031261 )
2015
47
Could a Transient Deficiency in Von Willebrand Factor be a Cause of Gastrointestinal Angiodysplasia? ( 25723359 )
2015
48
Success of Minimally Invasive Transumbilical Single-Incision Laparoscopic Surgery (T-SILS) Plus Double-Balloon Endoscopy (DBE) for Pediatric Intestinal Angiodysplasia: A Case Report. ( 26011216 )
2015
49
The natural history of small bowel angiodysplasia. ( 26540240 )
2015
50
Clinical features and endoscopic findings in patients with actively bleeding colonic angiodysplasia. ( 25772855 )
2015

Variations for Angiodysplasia

Expression for Angiodysplasia

Search GEO for disease gene expression data for Angiodysplasia.

Pathways for Angiodysplasia

GO Terms for Angiodysplasia

Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ENG FGF2 SCT SST VEGFA
2 platelet alpha granule lumen GO:0031093 8.96 VEGFA VWF

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 ACVRL1 ENG FGF2 VEGFA
2 negative regulation of gene expression GO:0010629 9.69 ACVRL1 ENG VEGFA
3 regulation of signaling receptor activity GO:0010469 9.67 FGF2 SCT SST VEGFA
4 positive regulation of MAP kinase activity GO:0043406 9.6 FGF2 VEGFA
5 vasculogenesis GO:0001570 9.59 ENG VEGFA
6 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.58 ACVRL1 ENG
7 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 FGF2 VEGFA
8 positive regulation of cell division GO:0051781 9.57 FGF2 VEGFA
9 negative regulation of blood vessel endothelial cell migration GO:0043537 9.56 ACVRL1 FGF2
10 positive chemotaxis GO:0050918 9.55 FGF2 VEGFA
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.54 FGF2 VEGFA
12 positive regulation of BMP signaling pathway GO:0030513 9.52 ACVRL1 ENG
13 branching involved in blood vessel morphogenesis GO:0001569 9.49 ENG VEGFA
14 positive regulation of sprouting angiogenesis GO:1903672 9.48 FGF2 VEGFA
15 artery morphogenesis GO:0048844 9.46 ENG VEGFA
16 angiogenesis GO:0001525 9.46 ACVRL1 ENG FGF2 VEGFA
17 endocardial cushion morphogenesis GO:0003203 9.43 ACVRL1 ENG
18 positive regulation of endothelial cell proliferation GO:0001938 9.43 ACVRL1 FGF2 VEGFA
19 cell migration involved in sprouting angiogenesis GO:0002042 9.4 FGF2 VEGFA
20 dorsal aorta morphogenesis GO:0035912 9.32 ACVRL1 ENG
21 endocardial cushion to mesenchymal transition GO:0090500 8.96 ACVRL1 ENG
22 positive regulation of angiogenesis GO:0045766 8.92 ACVRL1 ENG FGF2 VEGFA

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 FGF2 VEGFA
2 transforming growth factor beta binding GO:0050431 8.96 ACVRL1 ENG
3 activin binding GO:0048185 8.62 ACVRL1 ENG

Sources for Angiodysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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