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MCID: ANG011
MIFTS: 43

Angiodysplasia

Categories: Cardiovascular diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiodysplasia

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MalaCards integrated aliases for Angiodysplasia:

Name: Angiodysplasia 12 54 43 15 71
Angiodysplasia of Colon 71 32
Angiodysplasia of Stomach and Duodenum with Hemorrhage 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2494
MeSH 43 D016888
SNOMED-CT 67 71072006
ICD10 32 K55.2
UMLS 71 C0085411 C0267370
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Summaries for Angiodysplasia

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Disease Ontology : 12 A vascular disease that is characterized as a small vascular malformation of the gut.

MalaCards based summary : Angiodysplasia, also known as angiodysplasia of colon, is related to angiodysplasia of intestine and telangiectasis. An important gene associated with Angiodysplasia is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Complement and coagulation cascades and Angiogenesis (CST). The drugs Warfarin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and kidney, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 74 In medicine (gastroenterology), angiodysplasia is a small vascular malformation of the gut. It is a... more...

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Related Diseases for Angiodysplasia

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Diseases related to Angiodysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 angiodysplasia of intestine 33.9 ATP4A ATP12A
2 telangiectasis 31.1 VEGFA ENG ACVRL1
3 varicose veins 31.0 VWF VEGFA FGF2
4 weber syndrome 30.8 SST ENG ACVRL1
5 gastric antral vascular ectasia 30.3 SST ATP4A ATP12A
6 glucagonoma 30.3 SST SCT
7 von willebrand's disease 30.3 VWF F8 F3 ADAMTS13
8 arteriovenous malformation 30.3 VEGFA ENG ANGPT2 ACVRL1
9 gastritis 30.2 SST SCT ATP4A
10 duodenitis 30.1 ATP4A ATP12A
11 internal hemorrhoid 30.1 ATP4A ATP12A
12 bernard-soulier syndrome 30.1 VWF F8 ATAT1
13 intestinal perforation 29.9 VEGFA ATP4A ATP12A
14 liver cirrhosis 29.9 SST SCT F3 ADAMTS13
15 diverticulitis 29.9 FGF2 ATP4A ATP12A
16 hereditary hemorrhagic telangiectasia 29.8 VWF VEGFA ENG ANGPT2 ACVRL1
17 active peptic ulcer disease 29.8 VWF SST F3 ATP4A ATP12A ACVRL1
18 intestinal obstruction 29.8 SST ATP4A ATP12A
19 von willebrand disease, type 2 29.7 VWF SIGLEC5 F8 ATAT1
20 moyamoya disease 1 29.7 VWF VEGFA FGF2 F3
21 pulmonary embolism 29.7 VWF F8 F3
22 angiosarcoma 29.6 VWF VEGFA ANGPT2
23 nephrosclerosis 29.6 VEGFA F3 ADAMTS13
24 esophageal varix 29.6 SST F3 ATP4A ATP12A
25 portal hypertension 29.6 VWF VEGFA SST F3 ADAMTS13
26 capillary hemangioma 29.6 VWF VEGFA FGF2 ANGPT2
27 disseminated intravascular coagulation 29.6 VWF F3 ADAMTS13
28 peptic ulcer disease 29.5 SST SCT ATP4A ATP12A
29 zollinger-ellison syndrome 29.5 SST SCT ATP4A ATP12A
30 factor viii deficiency 29.5 VWF F8 F3
31 hemophilia a 29.5 VWF F8 F3
32 exanthem 29.3 VEGFA F3 ATP4A ATP12A
33 peripheral vascular disease 29.3 VWF VEGFA F3 ENG ACVRL1
34 von willebrand disease, type 1 29.3 VWF SIGLEC5 F8 F3 ATAT1
35 multiple endocrine neoplasia, type i 29.2 SST SCT FGF2 ATP4A ATP12A
36 hemangioma 29.2 VWF VEGFA FGF2 F3 ENG ANGPT2
37 acquired von willebrand syndrome 29.2 VWF F8 F3 ATAT1 ADAMTS13
38 vascular disease 29.0 VWF VEGFA FGF2 F8 F3 ENG
39 hemorrhagic disease 28.9 VWF F8 F3 ADAMTS13
40 pre-eclampsia 28.9 VWF VEGFA F8 F3 ENG
41 peripheral artery disease 28.4 VWF VEGFA FGF2 F3 ENG ANGPT2
42 hypothyroidism 28.4 VWF VEGFA SST F8 F3 ATP4A
43 hypertension, essential 28.0 VWF VEGFA SST FGF2 F3 ENG
44 myocardial infarction 28.0 VWF VEGFA FGF2 F8 F3 ENG
45 heart disease 27.9 VWF VEGFA FGF2 F8 F3 ENG
46 angioosteohypotrophic syndrome 11.6
47 telangiectasia, hereditary hemorrhagic, type 4 11.3
48 nevada syndrome 11.2
49 iron metabolism disease 10.5
50 radiation proctitis 10.5 VEGFA FGF2

Graphical network of the top 20 diseases related to Angiodysplasia:



Diseases related to Angiodysplasia
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Symptoms & Phenotypes for Angiodysplasia

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MGI Mouse Phenotypes related to Angiodysplasia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 ACVRL1 ANGPT2 ATP12A ATP4A ENG SST
2 hematopoietic system MP:0005397 9.85 ACVRL1 ADAMTS13 ATAT1 ATP4A ENG F3
3 homeostasis/metabolism MP:0005376 9.73 ACVRL1 ADAMTS13 ANGPT2 ATP12A ATP4A ENG
4 mortality/aging MP:0010768 9.4 ACVRL1 ADAMTS13 ANGPT2 ATAT1 ATP4A ENG
Sources

Drugs & Therapeutics for Angiodysplasia

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Drugs for Angiodysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 6691 54678486
2
Dalteparin Approved Phase 4 9005-49-6
3 Bemiparin Approved, Investigational Phase 4 91449-79-5
4
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
5
Phylloquinone Approved, Investigational Phase 4 84-80-0
6
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
7
Thrombin Approved, Investigational Phase 4
8
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
9 Menaquinone Investigational Phase 4 1182-68-9
10 Fibrinolytic Agents Phase 4
11 Anticoagulants Phase 4
12 Heparin, Low-Molecular-Weight Phase 4
13 Vitamin K Phase 4
14 calcium heparin Phase 4
15 naphthoquinone Phase 4
16
Iron Approved, Experimental Phase 2, Phase 3 7439-89-6, 15438-31-0 23925 27284
17
Octreotide Approved, Investigational Phase 2, Phase 3 83150-76-9 383414 6400441
18
Somatostatin Approved, Investigational Phase 2, Phase 3 51110-01-1, 38916-34-6 53481605
19 Gastrointestinal Agents Phase 2, Phase 3
20 Antineoplastic Agents, Hormonal Phase 2, Phase 3
21
Pasireotide Approved Phase 2 396091-73-9 9941444
22
Ferrous succinate Approved Phase 2 10030-90-7
23 Hormone Antagonists Phase 2
24 Hormones Phase 2
25
Pomalidomide Approved Phase 1 19171-19-8
26
Infliximab Approved 170277-31-3
27 Cola
28 Hemostatics

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina
2 A Multicenter, Randomized, Open-label Clinical Trial Assessing the Efficacy of Octreotide in Decreasing Blood and Iron Requirements in Patients With Refractory Anaemia Due to Angiodysplasias Recruiting NCT02384122 Phase 2, Phase 3 Octreotide
3 Randomized Phase II Trial Evaluating the Efficiency of Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure Completed NCT02622906 Phase 2 Pasireotide;Placebo
4 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
5 Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation : An Open-label, Randomized, Parallel Controlled Study Completed NCT00964496 Phase 2 Thalidomide;Iron
6 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Recruiting NCT03302858 Phase 2
7 A Randomised, Double-blind, Placebo-controlled Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding Withdrawn NCT02754960 Phase 2 Thalidomide;Placebo
8 Safety and Efficacy of Octreotide LAR Depot in Left Ventricular Assist Device (LVAD) Associate Gastrointestinal (GI) Completed NCT01707225 Phase 1 Octreotide LAR Depot
9 A Phase I Single Arm Study to Assess the Safety and Efficacy of Pomalidomide in Patients With Bleeding Due to Hereditary Hemorrhagic Telangiectasia and Refractory Angiodysplasia Recruiting NCT02287558 Phase 1 Pomalidomide
10 Prophylactic Elective Clipping of Colonic Diverticula in Patients Who Have Had Sustained Lower Gastrointestinal Haemorrhage Unknown status NCT02094456
11 Clinical and Molecular Characterization of Cerebral Proliferative Vasculopathy Completed NCT03293134
12 A Prospective Observational Cohort Study of Hemospray for Lower Gastrointestinal Hemorrhage (APPROACH LGI) Completed NCT02099435
13 A Randomized Controlled Trial of Capsule Endoscopy vs Standard Care in Patients With Iron Deficiency Anemia With Suspected Obscure / Occult Gastrointestinal Bleeding Completed NCT00694954
14 Prospective Comparison of the Diagnostic Yield of Small Bowel Pillcam SB2 and Capsocam Capsule in Patients With Obscure Digestive Bleedings Completed NCT01820182
15 Comparison of Early Vs Delayed Feeding on Rebleeding Following Endoscopic Ligation for Acute Esophageal Variceal Bleeding Completed NCT03306095
16 A Multicentre Prospective Observational Study to Evaluate the Utilisation, Effectiveness and Safety of Purastat® in the Management of Gastrointestinal Bleeding Recruiting NCT03983707
17 Role of MSCT Angiography in Evaluation of Lower Gastrointestinal Bleeding Not yet recruiting NCT03464513
18 Yield of Colonoscopy in Children With Bleeding Per Rectum Attending Gastrointestinal Endoscopic Unit In Assuit University Children Hospital Not yet recruiting NCT03596320
19 Upper Gastrointestinal Endoscopic Findings In Chronic Kidney Disease And Haemodialyzed Patients In Assiut University Hospitals Not yet recruiting NCT04098120
20 Prospective Evaluation of Same Day Bidirectional Endoscopy for Occult Bleeding Terminated NCT00636597
21 Treatment of Ex-vivo Small Bowel Mucosa With a Dedicated Radiofrequency Ablation (SB-RFA) Catheter. Withdrawn NCT03320395

Search NIH Clinical Center for Angiodysplasia

Cochrane evidence based reviews: angiodysplasia

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Genetic Tests for Angiodysplasia

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Anatomical Context for Angiodysplasia

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MalaCards organs/tissues related to Angiodysplasia:

40
Colon, Small Intestine, Kidney, Heart, Liver, Lung, Bone
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Publications for Angiodysplasia

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Articles related to Angiodysplasia:

(show top 50) (show all 1433)
# Title Authors PMID Year
1
[Analysis of molecular background of hereditary haemorrhagic telangiectasia--Rendu-Osler-Weber disease--preliminary results]. 54 61
19205515 2008
2
DHPLC-based mutation analysis of ENG and ALK-1 genes in HHT Italian population. 54 61
16429404 2006
3
Gastrointestinal bleeding in von Willebrand disease. 54 61
16542710 2006
4
Early transfusion of factor VIII/von Willebrand factor concentrates seems to be effective in the treatment of gastrointestinal bleeding in patients with von Willebrand type III disease. 54 61
11554939 2001
5
Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. 54 61
10187774 1999
6
Risk factors for bleeding from gastrointestinal angiodysplasia: a case-control study in patients with bleeding and non-bleeding angiodysplasia. 61
32018316 2020
7
Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature. 61
31498527 2020
8
Angiodysplasia in terminal ileum: Case report and review of literature. 61
31862659 2020
9
The impact of inpatient capsule endoscopy on the need for therapeutic interventions in patients with obscure gastrointestinal bleeding. 61
31997779 2020
10
Expression of angiogenic factors in the uteroplacental unit is altered at time of placentation in a porcine model of von Willebrand disease type 1. 61
31806575 2019
11
New therapies for von Willebrand disease. 61
31808884 2019
12
A histological description of intestinal 'angiodysplasia' in an autopsy case of Heyde's syndrome. 61
31872535 2019
13
Thalidomide for the treatment of angiodysplasia-related recurrent gastrointestinal hemorrhage: Is low dose a safe and viable option? 61
31893059 2019
14
Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000® left ventricular assist device. 61
31338629 2019
15
New therapies for von Willebrand disease. 61
31714963 2019
16
Changes in Lower Gastrointestinal Bleeding Presentation, Management, and Outcomes Over a 10-Year Span. 61
31593973 2019
17
Transcatheter aortic valve implantation in a patient with suspected hereditary von Willebrand disease and severe gastrointestinal bleeding - a case report. 61
31324129 2019
18
The incidence, risk factors, and outcomes of gastrointestinal bleeding in patients with a left ventricular assist device: a Japanese single-center cohort study. 61
31705323 2019
19
Characterization of a Porcine Model for Von Willebrand Disease Type 1 and 3 Regarding Expression of Angiogenic Mediators in the Nonpregnant Female Reproductive Tract. 61
31526432 2019
20
Rituximab to the rescue: novel therapy for chronic gastrointestinal bleeding due to angiodysplasia and acquired von Willebrand syndrome. 61
31656571 2019
21
Alternative trafficking of Weibel-Palade body proteins in CRISPR/Cas9-engineered von Willebrand factor-deficient blood outgrowth endothelial cells. 61
31624792 2019
22
Secondary angiodysplasia-associated gastrointestinal bleeding in end-stage renal disease: Results from the nationwide inpatient sample. 61
31798771 2019
23
Thulium laser coagulation: a new effective endotherapy to treat gastrointestinal angiodysplasia. 61
31327343 2019
24
Disappearance of Angiodysplasia Following Transcatheter Aortic Valve Implantation in a Patient with Heyde's Syndrome: A Case Report and Review of the Literature. 61
31378751 2019
25
Heyde Syndrome: Aortic Stenosis and Beyond. 61
31230737 2019
26
[Treatment of nonvariceal upper gastrointestinal bleeding: endoluminal-endovascular-surgical]. 61
31392464 2019
27
Gastrointestinal angiodysplasia in two patients with type 3 von Willebrand disease. 61
31261161 2019
28
Von Willebrand disease and gastrointestinal bleeding: A national inpatient sample study. 61
31026662 2019
29
Arteriovenous malformations within jejunal diverticulosis: case report and literature review. 61
31248400 2019
30
Is a bleeding scan prior to single-balloon enteroscopy necessary in patients with obscure gastrointestinal bleeding? 61
30473414 2019
31
Recurrent Gastrointestinal Bleeding from Dieulafoy's Lesions in a Patient with Type 1 von Willebrand Disease: A Rare Association. 61
31192289 2019
32
Clinical characteristics and risk factors of active bleeding in colonic angiodysplasia among the Taiwanese. 61
30348493 2019
33
Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases. 61
30867356 2019
34
Risk factors for incidentally detected and symptomatic angiodysplasias: a case-control study with the general population as reference. 61
30562184 2019
35
Functional capillary impairment in patients with ventricular assist devices. 61
30976042 2019
36
Alarming Increasing Trends in Hospitalizations and Mortality With Heyde's Syndrome: A Nationwide Inpatient Perspective (2007 to 2014). 61
30660352 2019
37
[A Resected Case with Early Gastric Cancer That Was Overdiagnosed as Scirrhous Gastric Cancer]. 61
30914596 2019
38
A Two-Month-Old Child with Vascular Ectasia: A Case Report Diagnosed by Molecular Karyotyping. 61
30775049 2019
39
Microcystin-LR induces angiodysplasia and vascular dysfunction through promoting cell apoptosis by the mitochondrial signaling pathway. 61
30485828 2019
40
Nomenclature and semantic description of vascular lesions in small bowel capsule endoscopy: an international Delphi consensus statement. 61
30834297 2019
41
Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease. 61
30837783 2019
42
Short article: Hormone therapy for severe gastrointestinal bleeding due to multiple angiodysplastic lesions. 61
30676471 2019
43
Multiple venous malformations in the left colon and rectum: a long-standing case managed conservatively and an update of current literature. 61
30902841 2019
44
Superselective Transcatheter Arterial Embolization in the Treatment of Angiodysplasia. 61
31205432 2019
45
Blood inflammatory and endothelial markers in women with von Willebrand disease. 61
30629692 2019
46
Acquired von Willebrand Syndrome and Chronic Anaemia: A Different Diagnostic Approach. 61
31293998 2019
47
Obscure gastrointestinal bleeding resulting from small bowel neoplasia; A case series. 61
31207533 2019
48
Clinical and endoscopic features of severe acute gastrointestinal bleeding in elderly patients treated with direct oral anticoagulants: a multicentre study. 61
31244894 2019
49
Gastrointestinal lesions in chronic kidney disease patients with anaemia. 61
30153940 2019
50
Rotational thromboelastometry-guided perioperative management of coagulation in a patient with Heyde's syndrome undergoing transcatheter aortic valve implantation. 61
32026002 2019
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Variations for Angiodysplasia

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Expression for Angiodysplasia

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Search GEO for disease gene expression data for Angiodysplasia.
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Pathways for Angiodysplasia

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Pathways related to Angiodysplasia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Complement and coagulation cascades 1 36
11.29 VWF F8 F3
2
Angiogenesis (CST) 4
10.97 VWF FGF2 F3 ENG ANGPT2
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GO Terms for Angiodysplasia

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Cellular components related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 VEGFA F3 ENG ADAMTS13 ACVRL1
2 extracellular region GO:0005576 9.61 VWF VEGFA SST SCT FGF2 F8
3 platelet alpha granule lumen GO:0031093 9.33 VWF VEGFA F8
4 extracellular space GO:0005615 9.32 VEGFA SST SCT FGF2 F8 F3

Biological processes related to Angiodysplasia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.73 VWF VEGFA F8
2 blood coagulation GO:0007596 9.71 VWF F8 F3 ADAMTS13
3 platelet activation GO:0030168 9.7 VWF F8 ADAMTS13
4 angiogenesis GO:0001525 9.65 VEGFA FGF2 ENG ANGPT2 ACVRL1
5 cell migration involved in sprouting angiogenesis GO:0002042 9.58 VEGFA FGF2
6 endocardial cushion morphogenesis GO:0003203 9.57 ENG ACVRL1
7 blood coagulation, intrinsic pathway GO:0007597 9.55 VWF F8
8 cellular sodium ion homeostasis GO:0006883 9.54 ATP4A ATP12A
9 negative regulation of blood vessel endothelial cell migration GO:0043537 9.54 FGF2 ANGPT2 ACVRL1
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.51 ATP4A ATP12A
11 sodium ion export across plasma membrane GO:0036376 9.49 ATP4A ATP12A
12 cellular potassium ion homeostasis GO:0030007 9.48 ATP4A ATP12A
13 positive regulation of positive chemotaxis GO:0050927 9.46 VEGFA F3
14 positive regulation of endothelial cell proliferation GO:0001938 9.46 VEGFA FGF2 F3 ACVRL1
15 dorsal aorta morphogenesis GO:0035912 9.43 ENG ACVRL1
16 endocardial cushion to mesenchymal transition GO:0090500 9.32 ENG ACVRL1
17 hemostasis GO:0007599 9.26 VWF F8 F3 ADAMTS13
18 positive regulation of angiogenesis GO:0045766 9.1 VEGFA FGF2 F3 ENG ANGPT2 ACVRL1

Molecular functions related to Angiodysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.5 VWF FGF2 ADAMTS13
2 activin binding GO:0048185 9.26 ENG ACVRL1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Angiodysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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