AEACEI
MCID: ANG049
MIFTS: 32

Angioedema Induced by Ace Inhibitors (AEACEI)

Categories: Bone diseases, Cardiovascular diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

MalaCards integrated aliases for Angioedema Induced by Ace Inhibitors:

Name: Angioedema Induced by Ace Inhibitors 57 75
Angioedema Induced by Ace Inhibitors, Susceptibility to 57 29 6 40
Acquired Angioedema 59 73
Aeacei 57 75
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema 59
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema 59
Drug-Related Side Effects and Adverse Reactions 44
Acquired Non Histamine-Induced Angioedema 59
Raas-Blocker-Induced Angioneurotic Edema 59
Acquired Bradykinine-Induced Angioedema 59
Acquired C1 Inhibitor Deficiency 59
Raas-Blocker-Induced Angioedema 59
Acquired Angioneurotic Edema 59
Ae-Acei 75
Rae 59
Aae 59

Characteristics:

Orphanet epidemiological data:

59
acquired angioedema
Inheritance: Not applicable; Age of onset: Adult;
renin-angiotensin-aldosterone system-blocker-induced angioedema
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

OMIM 57 300909
ICD10 via Orphanet 34 T78.3
MESH via Orphanet 45 C538173
UMLS via Orphanet 74 C2931758
SNOMED-CT via HPO 69 400075008 41291007
UMLS 73 C2931758

Summaries for Angioedema Induced by Ace Inhibitors

OMIM : 57 Approximately 40 million people take ACE inhibitors (ACEi) to treat hypertension and cardiovascular disease. A small proportion of white patients who take ACEi (0.1-0.7%) develop angioedema (AEACEI) (Israili and Hall, 1992; Vleeming et al., 1998), a potentially life-threatening side effect characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. ACEi-associated angioedema is 4 to 5 times more prevalent among African Americans (Brown et al., 1996; Coats, 2002). Other risk factors include female sex, smoking, immunosuppressant therapy, and seasonal allergies. The pathophysiology of ACEi-associated angioedema is thought to be related to increased circulating bradykinin, which is normally degraded by ACE. During pharmacologic ACE inhibition, bradykinin is primarily degraded by aminopeptidase P (summary by Duan et al., 2005 and Woodard-Grice et al., 2010). Aminopeptidase P is encoded by 3 genes: XPNPEP1 (602443) on chromosome 10q25, XPNPEP2 (300145) on chromosome Xq25, and XPNPEP3 (613553) on chromosome 22q13. (300909)

MalaCards based summary : Angioedema Induced by Ace Inhibitors, also known as angioedema induced by ace inhibitors, susceptibility to, is related to acquired angioedema and acquired angioedema type 2. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-Prolyl Aminopeptidase 2). Affiliated tissues include tongue, bone and b cells, and related phenotypes are angioedema and ascites

UniProtKB/Swiss-Prot : 75 Angioedema induced by ACE inhibitors: A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.

Related Diseases for Angioedema Induced by Ace Inhibitors

Diseases related to Angioedema Induced by Ace Inhibitors via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 acquired angioedema 12.6
2 acquired angioedema type 2 12.4
3 acquired angioedema type 1 12.2
4 reactive angioendotheliomatosis 11.7
5 angioedema, hereditary, type i 11.5
6 complement component 4, partial deficiency of 10.3
7 c1 inhibitor deficiency 10.3
8 angioedema 10.2
9 lymphoma 10.2
10 hereditary angioedema 10.1
11 west nile virus 10.1
12 viral infectious disease 10.1
13 leukemia, chronic lymphocytic 2 10.0
14 leukemia, chronic lymphocytic 10.0
15 lymphocytic leukemia 10.0
16 leukemia, b-cell, chronic 10.0
17 lymphoproliferative syndrome 10.0
18 melkersson-rosenthal syndrome 10.0
19 sjogren syndrome 10.0
20 lymphosarcoma 10.0
21 blepharochalasis and double lip 9.8
22 systemic lupus erythematosus 9.8
23 thrombophilia due to thrombin defect 9.8
24 anemia, autoimmune hemolytic 9.8
25 myelofibrosis 9.8
26 helicobacter pylori infection 9.8
27 psoriatic arthritis 9.8
28 antithrombin iii deficiency 9.8
29 autoimmune lymphoproliferative syndrome, type v 9.8
30 anaplastic large cell lymphoma 9.8
31 arthritis 9.8
32 b-cell lymphomas 9.8
33 hemolytic anemia 9.8
34 hepatitis 9.8
35 leukemia 9.8
36 marginal zone b-cell lymphoma 9.8
37 sinusitis 9.8
38 splenic marginal zone lymphoma 9.8
39 thrombosis 9.8
40 hepatitis c 9.8
41 antiphospholipid syndrome 9.8
42 adenocarcinoma 9.8
43 human immunodeficiency virus infectious disease 9.8
44 lupus erythematosus 9.8

Graphical network of the top 20 diseases related to Angioedema Induced by Ace Inhibitors:



Diseases related to Angioedema Induced by Ace Inhibitors

Symptoms & Phenotypes for Angioedema Induced by Ace Inhibitors

Clinical features from OMIM:

300909

Human phenotypes related to Angioedema Induced by Ace Inhibitors:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 angioedema 59 32 Very frequent (99-80%) HP:0100665
2 ascites 59 Occasional (29-5%)
3 abdominal pain 59 Very frequent (99-80%)
4 edema 59 Very frequent (99-80%)
5 intestinal obstruction 59 Occasional (29-5%)
6 urticaria 59 Occasional (29-5%)
7 facial edema 59 Occasional (29-5%)
8 intestinal edema 59 Occasional (29-5%)
9 laryngeal edema 59 Occasional (29-5%)

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

Search Clinical Trials , NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Cochrane evidence based reviews: drug-related side effects and adverse reactions

Genetic Tests for Angioedema Induced by Ace Inhibitors

Genetic tests related to Angioedema Induced by Ace Inhibitors:

# Genetic test Affiliating Genes
1 Angioedema Induced by Ace Inhibitors, Susceptibility to 29 XPNPEP2

Anatomical Context for Angioedema Induced by Ace Inhibitors

MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

41
Tongue, Bone, B Cells

Publications for Angioedema Induced by Ace Inhibitors

Articles related to Angioedema Induced by Ace Inhibitors:

# Title Authors Year
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? ( 20163043 )
2009
2
[Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. ( 10198947 )
1999

Variations for Angioedema Induced by Ace Inhibitors

ClinVar genetic disease variations for Angioedema Induced by Ace Inhibitors:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 XPNPEP2 NG_011479.1: g.2846C> A single nucleotide variant risk factor rs3788853 GRCh37 Chromosome X, 128870791: 128870791
2 XPNPEP2 NG_011479.1: g.2846C> A single nucleotide variant risk factor rs3788853 GRCh38 Chromosome X, 129736814: 129736814

Expression for Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for Angioedema Induced by Ace Inhibitors

GO Terms for Angioedema Induced by Ace Inhibitors

Sources for Angioedema Induced by Ace Inhibitors

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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