AEACEI
MCID: ANG049
MIFTS: 22

Angioedema Induced by Ace Inhibitors (AEACEI)

Categories: Bone diseases, Cardiovascular diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Angioedema Induced by Ace Inhibitors

MalaCards integrated aliases for Angioedema Induced by Ace Inhibitors:

Name: Angioedema Induced by Ace Inhibitors 58 76
Angioedema Induced by Ace Inhibitors, Susceptibility to 58 30 6 41
Aeacei 58 76
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema 60
Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema 60
Drug-Related Side Effects and Adverse Reactions 45
Acquired Angioedema with Normal C1 Inhibitor 60
Ace Inhibitor-Related Acquired Angioedema 60
Raas-Blocker-Induced Angioneurotic Edema 60
Acquired Angioedema with Normal C1inh 60
Acei-Related Acquired Angioedema 60
Raas-Blocker-Induced Angioedema 60
Acquired Angioedema 74
Ae-Acei 76
Rae 60

Characteristics:

Orphanet epidemiological data:

60
renin-angiotensin-aldosterone system-blocker-induced angioedema
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:



External Ids:

OMIM 58 300909
ICD10 via Orphanet 35 T78.3
Orphanet 60 ORPHA100057
SNOMED-CT via HPO 70 400075008 41291007
UMLS 74 C2931758

Summaries for Angioedema Induced by Ace Inhibitors

OMIM : 58 Approximately 40 million people take ACE inhibitors (ACEi) to treat hypertension and cardiovascular disease. A small proportion of white patients who take ACEi (0.1-0.7%) develop angioedema (AEACEI) (Israili and Hall, 1992; Vleeming et al., 1998), a potentially life-threatening side effect characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. ACEi-associated angioedema is 4 to 5 times more prevalent among African Americans (Brown et al., 1996; Coats, 2002). Other risk factors include female sex, smoking, immunosuppressant therapy, and seasonal allergies. The pathophysiology of ACEi-associated angioedema is thought to be related to increased circulating bradykinin, which is normally degraded by ACE. During pharmacologic ACE inhibition, bradykinin is primarily degraded by aminopeptidase P (summary by Duan et al., 2005 and Woodard-Grice et al., 2010). Aminopeptidase P is encoded by 3 genes: XPNPEP1 (602443) on chromosome 10q25, XPNPEP2 (300145) on chromosome Xq25, and XPNPEP3 (613553) on chromosome 22q13. (300909)

MalaCards based summary : Angioedema Induced by Ace Inhibitors, also known as angioedema induced by ace inhibitors, susceptibility to, is related to reactive angioendotheliomatosis and angioedema, hereditary, type i. An important gene associated with Angioedema Induced by Ace Inhibitors is XPNPEP2 (X-Prolyl Aminopeptidase 2). Affiliated tissues include tongue and bone, and related phenotype is angioedema.

UniProtKB/Swiss-Prot : 76 Angioedema induced by ACE inhibitors: A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.

Related Diseases for Angioedema Induced by Ace Inhibitors

Diseases related to Angioedema Induced by Ace Inhibitors via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 reactive angioendotheliomatosis 11.7
2 angioedema, hereditary, type i 11.5
3 angioedema 10.2

Symptoms & Phenotypes for Angioedema Induced by Ace Inhibitors

Human phenotypes related to Angioedema Induced by Ace Inhibitors:

33
# Description HPO Frequency HPO Source Accession
1 angioedema 33 HP:0100665

Clinical features from OMIM:

300909

Drugs & Therapeutics for Angioedema Induced by Ace Inhibitors

Search Clinical Trials , NIH Clinical Center for Angioedema Induced by Ace Inhibitors

Cochrane evidence based reviews: drug-related side effects and adverse reactions

Genetic Tests for Angioedema Induced by Ace Inhibitors

Genetic tests related to Angioedema Induced by Ace Inhibitors:

# Genetic test Affiliating Genes
1 Angioedema Induced by Ace Inhibitors, Susceptibility to 30 XPNPEP2

Anatomical Context for Angioedema Induced by Ace Inhibitors

MalaCards organs/tissues related to Angioedema Induced by Ace Inhibitors:

42
Tongue, Bone

Publications for Angioedema Induced by Ace Inhibitors

Articles related to Angioedema Induced by Ace Inhibitors:

# Title Authors Year
1
Acute abdomen due to intestinal angioedema induced by ACE inhibitors: not so rare? ( 20163043 )
2009
2
[Angioedema induced by ACE inhibitors and angiotensin II-receptor antagonists: analysis of 98 cases]. ( 10198947 )
1999

Variations for Angioedema Induced by Ace Inhibitors

ClinVar genetic disease variations for Angioedema Induced by Ace Inhibitors:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 G6PD NM_000402.4(G6PD): c.653C> T (p.Ser218Phe) single nucleotide variant Conflicting interpretations of pathogenicity, other rs5030868 GRCh37 Chromosome X, 153762634: 153762634
2 G6PD NM_000402.4(G6PD): c.653C> T (p.Ser218Phe) single nucleotide variant Conflicting interpretations of pathogenicity, other rs5030868 GRCh38 Chromosome X, 154534419: 154534419
3 XPNPEP2 NG_011479.1: g.2846C> A single nucleotide variant risk factor rs3788853 GRCh37 Chromosome X, 128870791: 128870791
4 XPNPEP2 NG_011479.1: g.2846C> A single nucleotide variant risk factor rs3788853 GRCh38 Chromosome X, 129736814: 129736814

Expression for Angioedema Induced by Ace Inhibitors

Search GEO for disease gene expression data for Angioedema Induced by Ace Inhibitors.

Pathways for Angioedema Induced by Ace Inhibitors

GO Terms for Angioedema Induced by Ace Inhibitors

Sources for Angioedema Induced by Ace Inhibitors

3 CDC
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10 dbSNP
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17 EFO
18 ExPASy
20 FMA
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32 HMDB
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35 ICD10 via Orphanet
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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