Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ANG004
MIFTS: 35

Angioid Streaks

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Angioid Streaks

About this section

MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 57 12 55 44 15 17 72

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13401
OMIM 57 607140
MeSH 44 D000793
MedGen 42 C0002982
UMLS 72 C0002982
Sources

Summaries for Angioid Streaks

About this section
MalaCards based summary : Angioid Streaks is related to pseudoxanthoma elasticum and optic disk drusen. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial.

Wikipedia : 75 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch's membrane, an... more...

More information from OMIM: 607140
Sources

Related Diseases for Angioid Streaks

About this section

Diseases related to Angioid Streaks via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 pseudoxanthoma elasticum 31.6 XYLT2 XYLT1 GGCX ABCC6
2 optic disk drusen 30.2 VEGFA ABCC6
3 angioid streaks of choroid 12.5
4 tumoral calcinosis, hyperphosphatemic, familial, 1 11.8
5 anemia, congenital dyserythropoietic, type iii 11.7
6 arterial calcification of infancy 11.4
7 macular degeneration, age-related, 1 10.8
8 mammary paget's disease 10.7
9 thalassemia 10.6
10 hemoglobinopathy 10.6
11 ehlers-danlos syndrome 10.6
12 microvascular complications of diabetes 5 10.5
13 beta-thalassemia 10.5
14 sickle cell anemia 10.5
15 myopia 10.5
16 sickle cell disease 10.5
17 hereditary spherocytosis 10.4
18 abetalipoproteinemia 10.4
19 anemia, congenital dyserythropoietic, type ia 10.4
20 hyperphosphatemia 10.4
21 acromegaly 10.4
22 bone inflammation disease 10.4
23 paget's disease of bone 10.4
24 retinal detachment 10.3
25 sturge-weber syndrome 10.3
26 choroidal dystrophy, central areolar, 1 10.3
27 yemenite deaf-blind hypopigmentation syndrome 10.3
28 deficiency anemia 10.3
29 telangiectasis 10.3
30 retinal vein occlusion 10.3
31 histoplasmosis 10.3
32 vascular disease 10.3
33 epilepsy 10.3
34 central retinal vein occlusion 10.3
35 chorioretinitis 10.3
36 familial tumoral calcinosis 10.3
37 weber syndrome 10.3
38 angiomatosis 10.3
39 camurati-engelmann disease 10.1
40 marfan syndrome 10.1
41 porphyria cutanea tarda 10.1
42 dowling-degos disease 1 10.1
43 cholestasis-lymphedema syndrome 10.1
44 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
45 hemochromatosis, type 1 10.1
46 myeloma, multiple 10.1
47 nonarteritic anterior ischemic optic neuropathy 10.1
48 microvascular complications of diabetes 1 10.1
49 alpha-thalassemia 10.1
50 intraocular pressure quantitative trait locus 10.1

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks
Sources

Symptoms & Phenotypes for Angioid Streaks

About this section

Clinical features from OMIM:

607140
Sources

Drugs & Therapeutics for Angioid Streaks

About this section

Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4
Magnesium oxide Approved Phase 2 1309-48-4 14792
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6 Mitogens Phase 2
7 Endothelial Growth Factors Phase 2
8 Gastrointestinal Agents Phase 2
9 Antacids Phase 2
10 Magnesium Supplement Phase 2
11 Anti-Ulcer Agents Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
2 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
3 OCT, Visual Outcome and Angiographic Analysis of Choroidal Neovascularization in Six Eyes With Angioid Streaks Treated With a Single Intravitreal Injection of Bevacizumab Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
4 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
5 Intravitreal Aflibercept (Eylea) for Therapy of Choroidal Neovascularization (CNV) and Fibrovascular Proliferation (FVP) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT02537054 Phase 2 Aflibercept
6 Ranibizumab in Choroidal Neovascularization (CNV) Due to Pseudoxanthoma Elasticum (PXE, Groenblad-Strandberg-Syndrome) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
7 Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) Completed NCT01525875 Phase 2 Magnesium Oxide;Placebo
8 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
9 Ranibizumab Therapy for Choroidal Neovascularization Associated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
10 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients. Withdrawn NCT02573038 Phase 2 Aflibercept
11 Intravitreal Bevacizumab for Choroidal Neovascularization Secondary to Angioid Streaks: 24 Months Follow-up Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
12 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
13 Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy Completed NCT00803517
14 Characterization of Patients With Pseudoxanthoma Elasticum Active, not recruiting NCT02108392
15 Pilot Study of Intravitreal Bevacizumab vs. Combination Therapy for Choroidal Neovascularization Secondary to Causes Other Than Age-related Macular Degeneration Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

Sources

Genetic Tests for Angioid Streaks

About this section
Sources

Anatomical Context for Angioid Streaks

About this section

MalaCards organs/tissues related to Angioid Streaks:

41
Retina, Eye, Endothelial, Skin, Pituitary, Brain, Bone
Sources

Publications for Angioid Streaks

About this section

Articles related to Angioid Streaks:

(show top 50) (show all 602)
# Title Authors PMID Year
1
Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. 38 8
12208247 2002
2
Angioid streaks associated with abetalipoproteinemia. 38 8
7749670 1994
3
Angioid streaks in homozygous beta thalassemia. 38 8
2801854 1989
4
Angioid streaks. 38 8
7046115 1982
5
Angioid streaks in Ehlers-Danlos syndrome. 38 8
5945174 1966
6
Angioid streaks and sicklecell disease. 38 8
13827077 1960
7
Effect of large oral doses of vitamin E on the neurological sequelae of patients with abetalipoproteinemia. 8
6959555 1982
8
Novel mutations of ABCC6 gene in Japanese patients with Angioid streaks. 9 38
19284998 2009
9
[What can we learn from molecular genetic analyses of inherited eye diseases?]. 9 38
17134037 2006
10
[Mendelian arterial diseases. Pseudoxanthoma elasticum, Ehlers-Danlos vascular syndrome, Rendu-Osler disease]. 9 38
14694786 2003
11
Optic disc drusen, angioid streaks, and mottled fundus in various combinations in a Sicilian family. 9 38
12271376 2002
12
Acute Retinopathy in Pseudoxanthoma Elasticum. 38
31393536 2019
13
One-year outcomes of anti-vascular endothelial growth factor therapy in peripapillary choroidal neovascularisation. 38
31401554 2019
14
Retinal sensitivity in angioid streaks. 38
31044269 2019
15
Identification of hyperreflective foci in angioid streaks. 38
31278381 2019
16
Evaluation of lamina cribrosa in angioid streaks using spectral-domain optical coherence tomography enhanced depth imaging. 38
31101364 2019
17
Coquille d'oeuf in young patients affected with Pseudoxantoma elasticum. 38
31269855 2019
18
[Angioid streaks in systemic disease]. 38
31203643 2019
19
Unexpected ABCC6 mRNA splicing in a Chinese family with pseudoxanthoma elasticum. 38
30328268 2019
20
[Ocular manifestations in Ehlers-Danlos Syndromes: Clinical study of 21 patients]. 38
31133401 2019
21
Angioid streaks in pseudoxanthoma elasticum. 38
30580324 2019
22
Retinal findings in carriers of monoallelic ABCC6 mutations. 38
30923132 2019
23
Angioid Streaks Are Not a Common Feature of Ehlers-Danlos Syndrome. 38
30543351 2019
24
Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks. 38
30250237 2019
25
Switching from ranibizumab to aflibercept in choroidal neovascularization secondary to angioid streaks. 38
30880436 2019
26
Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population-the Bridlington eye assessment project (BEAP): a cross-sectional study (2002-2006). 38
30315265 2019
27
Anti-VEGF treatment for choroidal neovascularization complicating pattern dystrophy-like deposit associated with pseudoxanthoma elasticum. 38
30470876 2019
28
ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. 38
30260918 2019
29
Choroidal Neovascularization Resulting from Angioid Streaks in Pseudoxanthoma Elasticum. 38
30929814 2019
30
LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES. 38
30608346 2018
31
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. 38
28961674 2018
32
[Angioid streaks in a 33-year-old man with β-Thalassemia]. 38
30224095 2018
33
PNEUMATIC COMPACTION TREATMENT OF ACUTE SUBFOVEAL HEMORRHAGE AFTER BLUNT TRAUMA IN A PATIENT WITH ANGIOID STREAKS ASSOCIATED WITH PSEUDOXANTHOMA ELASTICUM. 38
30300312 2018
34
[Study of fundus examination by age in 158 pseudoxanthoma elasticum patients]. 38
30143311 2018
35
[Choroidal Neovascularisation Other than Typical Neovascular Age-Related Macular Degeneration]. 38
28282700 2018
36
ABCC6 mutations and early onset stroke: Two cases of a typical Pseudoxanthoma Elasticum. 38
29709427 2018
37
PSEUDOXANTHOMA ELASTICUM: SUCCESSFUL LONG-TERM MANAGEMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS WITH PRO RE NATA INTRAVITREAL BEVACIZUMAB INJECTIONS. 38
30048402 2018
38
Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks. 38
30025095 2018
39
BILATERAL CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH BETA-THALASSEMIA MAJOR AND ITS MANAGEMENT. 38
27768638 2018
40
Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks. 38
29687087 2018
41
MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA ELASTICUM. 38
29965887 2018
42
Reticular Pseudodrusen and Thin Choroid Are Associated With Angioid Streaks. 38
29927467 2018
43
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks. 38
29802262 2018
44
To laser or not? 38
29480271 2018
45
[Post-traumatic macular hematoma as presenting sign of angioid streaks: Role of spectral-domain optical coherence tomography (SD-OCT)]. 38
29395597 2018
46
MULTIMODAL IMAGING OF ANGIOID STREAKS ASSOCIATED WITH TURNER SYNDROME. 38
29443807 2018
47
Hyperphosphatemic Familial Tumoral Calcinosis 38
29389098 2018
48
Inborn Errors of Metabolism: Pseudoxanthoma Elasticum. 38
30578511 2018
49
Pharmacotherapy for Choroidal Neovascularization Due to Uncommon Causes. 38
30727875 2018
50
Central serous chorioretinopathy with angioid streaks: a rare combination. 38
29623251 2018
Sources

Variations for Angioid Streaks

About this section
Sources

Expression for Angioid Streaks

About this section
Search GEO for disease gene expression data for Angioid Streaks.
Sources

Pathways for Angioid Streaks

About this section

Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
heparan sulfate biosynthesis 1
Show member pathways
 10.46 XYLT2 XYLT1
Sources

GO Terms for Angioid Streaks

About this section

Cellular components related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.1 XYLT2 XYLT1 VEGFA GGCX CDAN1 ABCC6

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.37 XYLT2 XYLT1
2 chondroitin sulfate biosynthetic process GO:0030206 9.32 XYLT2 XYLT1
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.26 XYLT2 XYLT1
4 proteoglycan biosynthetic process GO:0030166 9.16 XYLT2 XYLT1
5 glycosaminoglycan metabolic process GO:0030203 8.96 XYLT2 XYLT1
6 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.62 XYLT2 XYLT1

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylglucosaminyltransferase activity GO:0008375 8.96 XYLT2 XYLT1
2 protein xylosyltransferase activity GO:0030158 8.62 XYLT2 XYLT1
Sources

Sources for Angioid Streaks

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....