MCID: ANG004
MIFTS: 36

Angioid Streaks

Categories: Eye diseases

Aliases & Classifications for Angioid Streaks

MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 57 12 55 44 15 73

Classifications:



External Ids:

OMIM 57 607140
Disease Ontology 12 DOID:13401
MeSH 44 D000793
MedGen 42 C0002982
UMLS 73 C0002982

Summaries for Angioid Streaks

MalaCards based summary : Angioid Streaks is related to pseudoxanthoma elasticum and angioid streaks of choroid. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotype is renal/urinary system.

Wikipedia : 76 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch''s membrane, an... more...

Description from OMIM: 607140

Related Diseases for Angioid Streaks

Diseases related to Angioid Streaks via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 pseudoxanthoma elasticum 32.4 ABCC6 XYLT1 XYLT2
2 angioid streaks of choroid 12.4
3 anemia, congenital dyserythropoietic, type iii 11.3
4 thalassemia 10.5
5 abetalipoproteinemia 10.3
6 beta-thalassemia 10.3
7 hereditary spherocytosis 10.3
8 paget disease of bone 3 10.2
9 sturge-weber syndrome 10.2
10 macular degeneration, age-related, 1 10.2
11 myopia 10.2
12 ehlers-danlos syndrome 10.2
13 vascular disease 10.2
14 hemoglobinopathy 10.2
15 sickle cell disease 10.2
16 weber syndrome 10.2
17 camurati-engelmann disease 10.1
18 porphyria cutanea tarda 10.1
19 tumoral calcinosis, hyperphosphatemic, familial, 1 10.1
20 cholestasis-lymphedema syndrome 10.1
21 hemochromatosis, type 1 10.1
22 nonarteritic anterior ischemic optic neuropathy 10.1
23 ischemic optic neuropathy 10.1
24 hyperphosphatemia 10.1
25 telangiectasis 10.1
26 porphyria 10.1
27 neovascular glaucoma 10.1
28 histoplasmosis 10.1
29 calcinosis 10.1
30 optic nerve disease 10.1
31 acromegaly 10.1
32 turner syndrome 10.1
33 retinitis 10.1
34 paget's disease of bone 10.1
35 neuropathy 10.1
36 juvenile hereditary hemochromatosis 10.1
37 central serous chorioretinopathy 10.1
38 degos 'en cocarde' erythrokeratoderma 10.1
39 familial tumoral calcinosis 10.1
40 eastern equine encephalitis 9.9 XYLT1 XYLT2
41 autosomal genetic disease 9.8 ABCC6 VEGFA
42 optic disk drusen 9.7 ABCC6 GALNT3 VEGFA

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks

Symptoms & Phenotypes for Angioid Streaks

Clinical features from OMIM:

607140

MGI Mouse Phenotypes related to Angioid Streaks:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 ABCC6 GALNT3 VEGFA XYLT2

Drugs & Therapeutics for Angioid Streaks

Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 1,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2,Not Applicable
4
Ranibizumab Approved Phase 1, Phase 2,Phase 2 347396-82-1 459903
5 Immunologic Factors Phase 1, Phase 2,Phase 2
6 Endothelial Growth Factors Phase 2
7 Mitogens Phase 2
8
Verteporfin Approved, Investigational Not Applicable 129497-78-5
9
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
11
Lactitol Investigational Not Applicable 585-86-4 3871
12 Hormones Not Applicable
13 Antineoplastic Agents, Hormonal Not Applicable
14 Anti-Inflammatory Agents Not Applicable
15 Photosensitizing Agents Not Applicable
16 Dermatologic Agents Not Applicable
17 glucocorticoids Not Applicable
18 Hormone Antagonists Not Applicable
19 HIV Protease Inhibitors Not Applicable
20 BB 1101 Not Applicable
21
protease inhibitors Not Applicable
22 Peripheral Nervous System Agents Not Applicable
23 Autonomic Agents Not Applicable
24 Antiemetics Not Applicable
25 Gastrointestinal Agents Not Applicable
26 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
2 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
3 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients (ASTRID). Withdrawn NCT02573038 Phase 2 Aflibercept
4 Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
5 Ranibizumab to Treat Choroidal Neovascularization (CNV) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
6 Intravitreal Aflibercept for Therapy of Patients With Pseudoxanthoma Elasticum (PXE) Active, not recruiting NCT02537054 Phase 2 Aflibercept
7 Intravitreal Bevacizumab in Agioid Streaks Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
8 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
9 Characterization of Pseudoxanthoma Elasticum Active, not recruiting NCT02108392
10 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

Genetic Tests for Angioid Streaks

Anatomical Context for Angioid Streaks

MalaCards organs/tissues related to Angioid Streaks:

41
Retina, Eye, Endothelial, Skin, Pituitary, Bone, Cervix

Publications for Angioid Streaks

Articles related to Angioid Streaks:

(show top 50) (show all 277)
# Title Authors Year
1
Reticular Pseudodrusen and Thin Choroid Are Associated With Angioid Streaks. ( 29927467 )
2018
2
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks. ( 29802262 )
2018
3
Central serous chorioretinopathy with angioid streaks: a rare combination. ( 29623251 )
2018
4
MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA ELASTICUM. ( 29965887 )
2018
5
MULTIMODAL IMAGING OF ANGIOID STREAKS ASSOCIATED WITH TURNER SYNDROME. ( 29443807 )
2018
6
Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks. ( 29687087 )
2018
7
Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks. ( 30025095 )
2018
8
PSEUDOXANTHOMA ELASTICUM: SUCCESSFUL LONG-TERM MANAGEMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS WITH PRO RE NATA INTRAVITREAL BEVACIZUMAB INJECTIONS. ( 30048402 )
2018
9
Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks. ( 30250237 )
2018
10
ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. ( 30260918 )
2018
11
Intravitreal aflibercept for choroidal neovascularization secondary to angioid streaks in a non-responder to intravitreal ranibizumab. ( 30271222 )
2018
12
PNEUMATIC COMPACTION TREATMENT OF ACUTE SUBFOVEAL HEMORRHAGE AFTER BLUNT TRAUMA IN A PATIENT WITH ANGIOID STREAKS ASSOCIATED WITH PSEUDOXANTHOMA ELASTICUM. ( 30300312 )
2018
13
Angioid Streaks Are Not a Common Feature of Ehlers Danlos Syndrome. ( 30543351 )
2018
14
Long-term follow-up of patients with choroidal neovascularization due to angioid streaks. ( 28031699 )
2017
15
Intravitreal Bevacizumab for Choroidal Neovascularization Associated with Angioid Streaks: Long-term Results. ( 29279654 )
2017
16
ABCC6 Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance. ( 28912966 )
2017
17
Optical coherence tomography analysis of evolution of Bruch's membrane features in angioid streaks. ( 28622313 )
2017
18
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. ( 28961674 )
2017
19
Angioid streaks in a case of Camurati-Engelmann disease. ( 28724827 )
2017
20
Detection of nonexudative choroidal neovascularization secondary to angioid streaks using optical coherence tomography angiography. ( 28574138 )
2017
21
Long-Term Follow-Up of Choroidal Neovascularization due to Angioid Streaks with pro re nata Intravitreal Anti-VEGF Treatment. ( 28641290 )
2017
22
Long-Term Follow-Up of Polypoidal Choroidal Vasculopathy Secondary to Angioid Streaks Treated by Intravitreal Aflibercept and Ranibizumab. ( 28512425 )
2017
23
Multiple Choroidal Ruptures in a Patient With Angioid Streaks. ( 28278344 )
2017
24
Intravitreal ranibizumab for choroidal neovascularization in a patient with angioid streaks and multiple evanescent white dots. ( 27457484 )
2016
25
Intravitreal aflibercept for refractory choroidal neovascularization secondary to angioid streaks. ( 26939555 )
2016
26
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26795411 )
2016
27
The effect of the acceleration/deceleration trauma in angioid streaks: A pathogenic hypothesis. ( 27021800 )
2016
28
Angioid streaks in aagenaes syndrome. ( 27614462 )
2016
29
Treat and extend regimen with aflibercept for choroidal neovascularization in angioid streaks. ( 26795418 )
2016
30
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26939557 )
2016
31
Angioid Streaks in the Fundus of a 13-Year-Old Girl. ( 27697324 )
2016
32
Intravitreal Bevacizumab for Nonsubfoveal Choroidal Neovascularization Associated With Angioid Streaks: 3-Year Follow-up Study. ( 27013066 )
2016
33
Silent polypoidal choroidal vasculopathy in a patient with angioid streaks. ( 27463636 )
2016
34
Angioid streaks complicated by choroidal neovascularization in Paget's disease. ( 27587348 )
2016
35
Angioid Streaks in Types I and II Congenital Dyserythropoietic Anaemia (CDA). ( 27116514 )
2016
36
LOCATING AND CHARACTERIZING ANGIOID STREAKS WITH EN FACE OPTICAL COHERENCE TOMOGRAPHY. ( 27145173 )
2016
37
Drastic effect of ranibizumab on choroidal neovascularization in idiopathic angioid streaks. ( 26375345 )
2015
38
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26021869 )
2015
39
INTRAVITREAL BEVACIZUMAB IN THE TREATMENT OF CHOROIDAL NEOVASCULAR MEMBRANE DUE TO ANGIOID STREAKS. ( 25996427 )
2015
40
Angioid streaks in association with sickle thalassemia trait. ( 25569313 )
2015
41
Corneal Viscoelastic Properties in Patients with Angioid Streaks. ( 25942046 )
2015
42
INTRAVITREAL RANIBIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN ANGIOID STREAKS: Four-Year Follow-up. ( 26355947 )
2015
43
Intravitreal aflibercept for management of subfoveal choroidal neovascularization secondary to angioid streaks. ( 26458482 )
2015
44
UngewAPhnliche posttraumatische Netzhautblutungen zeigen Angioid Streaks. ( 25902130 )
2015
45
VISUAL RECOVERY AFTER AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROIDAL PATCH IN A PATIENT WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS: LONG-TERM RESULTS. ( 26679062 )
2015
46
Peau d'orange and angioid streaks: manifestations of Bruch membrane pathology. ( 25526100 )
2015
47
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: a long-term follow-up study. ( 25044143 )
2014
48
Intravitreal bevacizumab for nonsubfoveal choroidal neovascularization associated with angioid streaks. ( 24211865 )
2014
49
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: A report of two patients. ( 25473350 )
2014
50
Successful long-term management of choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum: a case report. ( 25529762 )
2014

Variations for Angioid Streaks

Expression for Angioid Streaks

Search GEO for disease gene expression data for Angioid Streaks.

Pathways for Angioid Streaks

Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 XYLT1 XYLT2

GO Terms for Angioid Streaks

Cellular components related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 GALNT3 XYLT1 XYLT2

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.37 XYLT1 XYLT2
2 chondroitin sulfate biosynthetic process GO:0030206 9.32 XYLT1 XYLT2
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.26 XYLT1 XYLT2
4 proteoglycan biosynthetic process GO:0030166 9.16 XYLT1 XYLT2
5 glycosaminoglycan metabolic process GO:0030203 8.96 XYLT1 XYLT2
6 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.62 XYLT1 XYLT2

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.33 GALNT3 XYLT1 XYLT2
2 manganese ion binding GO:0030145 9.26 GALNT3 XYLT2
3 acetylglucosaminyltransferase activity GO:0008375 8.96 XYLT1 XYLT2
4 protein xylosyltransferase activity GO:0030158 8.62 XYLT1 XYLT2

Sources for Angioid Streaks

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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