MCID: ANG004
MIFTS: 36

Angioid Streaks

Categories: Eye diseases

Aliases & Classifications for Angioid Streaks

MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 58 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13401
OMIM 58 607140
MeSH 45 D000793
MedGen 43 C0002982
UMLS 74 C0002982

Summaries for Angioid Streaks

MalaCards based summary : Angioid Streaks is related to pseudoxanthoma elasticum and optic disk drusen. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, bone and eye.

Wikipedia : 77 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch''s membrane, an... more...

Description from OMIM: 607140

Related Diseases for Angioid Streaks

Diseases related to Angioid Streaks via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 pseudoxanthoma elasticum 32.2 ABCC6 XYLT1 XYLT2
2 optic disk drusen 30.1 ABCC6 VEGFA
3 angioid streaks of choroid 12.4
4 anemia, congenital dyserythropoietic, type iii 11.7
5 thalassemia 10.5
6 mammary paget's disease 10.5
7 abetalipoproteinemia 10.4
8 beta-thalassemia 10.4
9 hereditary spherocytosis 10.4
10 paget disease of bone 3 10.3
11 sturge-weber syndrome 10.3
12 tumoral calcinosis, hyperphosphatemic, familial, 1 10.3
13 macular degeneration, age-related, 1 10.3
14 myopia 10.3
15 ehlers-danlos syndrome 10.3
16 vascular disease 10.3
17 hemoglobinopathy 10.3
18 bone inflammation disease 10.3
19 sickle cell disease 10.3
20 weber syndrome 10.3
21 camurati-engelmann disease 10.1
22 porphyria cutanea tarda 10.1
23 cholestasis-lymphedema syndrome 10.1
24 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
25 hemochromatosis, type 1 10.1
26 nonarteritic anterior ischemic optic neuropathy 10.1
27 yemenite deaf-blind hypopigmentation syndrome 10.1
28 ischemic optic neuropathy 10.1
29 liver disease 10.1
30 hyperphosphatemia 10.1
31 telangiectasis 10.1
32 porphyria 10.1
33 neovascular glaucoma 10.1
34 histoplasmosis 10.1
35 calcinosis 10.1
36 optic nerve disease 10.1
37 acromegaly 10.1
38 turner syndrome 10.1
39 retinitis 10.1
40 paget's disease of bone 10.1
41 neuropathy 10.1
42 juvenile hereditary hemochromatosis 10.1
43 central serous chorioretinopathy 10.1
44 degos 'en cocarde' erythrokeratoderma 10.1
45 familial tumoral calcinosis 10.1
46 eastern equine encephalitis 9.8 XYLT1 XYLT2
47 autosomal genetic disease 9.7 ABCC6 VEGFA

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks

Symptoms & Phenotypes for Angioid Streaks

Clinical features from OMIM:

607140

Drugs & Therapeutics for Angioid Streaks

Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 1,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Phase 1,Phase 2,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Phase 1,Phase 2,Not Applicable
4 Antineoplastic Agents, Immunological Phase 3,Phase 1,Not Applicable
5
Ranibizumab Approved Phase 1, Phase 2,Phase 2 347396-82-1 459903
6 Endothelial Growth Factors Phase 2
7 Mitogens Phase 2
8
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
9
Verteporfin Approved, Investigational Not Applicable 129497-78-5
10
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
11
Phylloquinone Approved, Investigational Not Applicable 84-80-0
12 Menaquinone Approved, Investigational Not Applicable 1182-68-9
13
Menadione Approved, Nutraceutical Not Applicable 58-27-5 4055
14
Lactitol Investigational Not Applicable 585-88-6, 585-86-4 493591
15
protease inhibitors Not Applicable
16 Antineoplastic Agents, Hormonal Not Applicable
17 Dermatologic Agents Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
19 Anti-Inflammatory Agents Not Applicable
20 Hormones Not Applicable
21 Autonomic Agents Not Applicable
22 Antiemetics Not Applicable
23 Gastrointestinal Agents Not Applicable
24 glucocorticoids Not Applicable
25 Photosensitizing Agents Not Applicable
26 BB 1101 Not Applicable
27 Hormone Antagonists Not Applicable
28 Peripheral Nervous System Agents Not Applicable
29 HIV Protease Inhibitors Not Applicable
30 Micronutrients Not Applicable
31 Vitamins Not Applicable
32 Antifibrinolytic Agents Not Applicable
33 Hemostatics Not Applicable
34 Coagulants Not Applicable
35 Vitamin K 2 Not Applicable
36 Vitamin MK 7 Not Applicable
37 Nutrients Not Applicable
38 naphthoquinone Not Applicable
39 Vitamin K Not Applicable
40 Trace Elements Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
2 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
3 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients (ASTRID). Withdrawn NCT02573038 Phase 2 Aflibercept
4 Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
5 Ranibizumab to Treat Choroidal Neovascularization (CNV) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
6 Intravitreal Aflibercept for Therapy of Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT02537054 Phase 2 Aflibercept
7 Intravitreal Bevacizumab in Agioid Streaks Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
8 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
9 Characterization of Pseudoxanthoma Elasticum Active, not recruiting NCT02108392
10 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy
11 Intestinal Microbiota and Vitamin K Levels in PXE Patients (IMPROVE Study) Recruiting NCT03813550 Not Applicable

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

Genetic Tests for Angioid Streaks

Anatomical Context for Angioid Streaks

MalaCards organs/tissues related to Angioid Streaks:

42
Retina, Bone, Eye, Endothelial, Skin, Pituitary, Cervix

Publications for Angioid Streaks

Articles related to Angioid Streaks:

(show top 50) (show all 283)
# Title Authors Year
1
Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks. ( 30250237 )
2019
2
ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. ( 30260918 )
2019
3
Switching from ranibizumab to aflibercept in choroidal neovascularization secondary to angioid streaks. ( 30880436 )
2019
4
Choroidal Neovascularization Resulting from Angioid Streaks in Pseudoxanthoma Elasticum. ( 30929814 )
2019
5
Retinal sensitivity in angioid streaks. ( 31044269 )
2019
6
Evaluation of lamina cribrosa in angioid streaks using spectral-domain optical coherence tomography enhanced depth imaging. ( 31101364 )
2019
7
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. ( 28961674 )
2018
8
MULTIMODAL IMAGING OF ANGIOID STREAKS ASSOCIATED WITH TURNER SYNDROME. ( 29443807 )
2018
9
Central serous chorioretinopathy with angioid streaks: a rare combination. ( 29623251 )
2018
10
Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks. ( 29687087 )
2018
11
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks. ( 29802262 )
2018
12
Reticular Pseudodrusen and Thin Choroid Are Associated With Angioid Streaks. ( 29927467 )
2018
13
MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA ELASTICUM. ( 29965887 )
2018
14
Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks. ( 30025095 )
2018
15
PSEUDOXANTHOMA ELASTICUM: SUCCESSFUL LONG-TERM MANAGEMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS WITH PRO RE NATA INTRAVITREAL BEVACIZUMAB INJECTIONS. ( 30048402 )
2018
16
Intravitreal aflibercept for choroidal neovascularization secondary to angioid streaks in a non-responder to intravitreal ranibizumab. ( 30271222 )
2018
17
PNEUMATIC COMPACTION TREATMENT OF ACUTE SUBFOVEAL HEMORRHAGE AFTER BLUNT TRAUMA IN A PATIENT WITH ANGIOID STREAKS ASSOCIATED WITH PSEUDOXANTHOMA ELASTICUM. ( 30300312 )
2018
18
Angioid Streaks Are Not a Common Feature of Ehlers Danlos Syndrome. ( 30543351 )
2018
19
Angioid streaks in pseudoxanthoma elasticum. ( 30580324 )
2018
20
LOCATING AND CHARACTERIZING ANGIOID STREAKS WITH EN FACE OPTICAL COHERENCE TOMOGRAPHY. ( 27145173 )
2017
21
Angioid streaks in aagenaes syndrome. ( 27614462 )
2017
22
Long-term follow-up of patients with choroidal neovascularization due to angioid streaks. ( 28031699 )
2017
23
Multiple Choroidal Ruptures in a Patient With Angioid Streaks. ( 28278344 )
2017
24
Long-Term Follow-Up of Polypoidal Choroidal Vasculopathy Secondary to Angioid Streaks Treated by Intravitreal Aflibercept and Ranibizumab. ( 28512425 )
2017
25
Detection of nonexudative choroidal neovascularization secondary to angioid streaks using optical coherence tomography angiography. ( 28574138 )
2017
26
Optical coherence tomography analysis of evolution of Bruch's membrane features in angioid streaks. ( 28622313 )
2017
27
Long-Term Follow-Up of Choroidal Neovascularization due to Angioid Streaks with pro re nata Intravitreal Anti-VEGF Treatment. ( 28641290 )
2017
28
Angioid streaks in a case of Camurati-Engelmann disease. ( 28724827 )
2017
29
ABCC6 Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance. ( 28912966 )
2017
30
Intravitreal Bevacizumab for Choroidal Neovascularization Associated with Angioid Streaks: Long-term Results. ( 29279654 )
2017
31
Ultra-Widefield Imaging in Patients with Angioid Streaks Secondary to Pseudoxanthoma Elasticum. ( 31047269 )
2017
32
INTRAVITREAL RANIBIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN ANGIOID STREAKS: Four-Year Follow-up. ( 26355947 )
2016
33
VISUAL RECOVERY AFTER AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROIDAL PATCH IN A PATIENT WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS: LONG-TERM RESULTS. ( 26679062 )
2016
34
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26795411 )
2016
35
Treat and extend regimen with aflibercept for choroidal neovascularization in angioid streaks. ( 26795418 )
2016
36
Intravitreal aflibercept for refractory choroidal neovascularization secondary to angioid streaks. ( 26939555 )
2016
37
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26939557 )
2016
38
Intravitreal Bevacizumab for Nonsubfoveal Choroidal Neovascularization Associated With Angioid Streaks: 3-Year Follow-up Study. ( 27013066 )
2016
39
The effect of the acceleration/deceleration trauma in angioid streaks: A pathogenic hypothesis. ( 27021800 )
2016
40
Angioid Streaks in Types I and II Congenital Dyserythropoietic Anaemia (CDA). ( 27116514 )
2016
41
Intravitreal ranibizumab for choroidal neovascularization in a patient with angioid streaks and multiple evanescent white dots. ( 27457484 )
2016
42
Silent polypoidal choroidal vasculopathy in a patient with angioid streaks. ( 27463636 )
2016
43
Angioid streaks complicated by choroidal neovascularization in Paget's disease. ( 27587348 )
2016
44
Angioid Streaks in the Fundus of a 13-Year-Old Girl. ( 27697324 )
2016
45
Corneal Viscoelastic Properties in Patients with Angioid Streaks. ( 25942046 )
2016
46
INTRAVITREAL BEVACIZUMAB IN THE TREATMENT OF CHOROIDAL NEOVASCULAR MEMBRANE DUE TO ANGIOID STREAKS. ( 25996427 )
2015
47
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26021869 )
2015
48
Drastic effect of ranibizumab on choroidal neovascularization in idiopathic angioid streaks. ( 26375345 )
2015
49
Intravitreal aflibercept for management of subfoveal choroidal neovascularization secondary to angioid streaks. ( 26458482 )
2015
50
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: a long-term follow-up study. ( 25044143 )
2015

Variations for Angioid Streaks

Expression for Angioid Streaks

Search GEO for disease gene expression data for Angioid Streaks.

Pathways for Angioid Streaks

Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 XYLT1 XYLT2

GO Terms for Angioid Streaks

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.37 XYLT1 XYLT2
2 chondroitin sulfate biosynthetic process GO:0030206 9.32 XYLT1 XYLT2
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.26 XYLT1 XYLT2
4 proteoglycan biosynthetic process GO:0030166 9.16 XYLT1 XYLT2
5 glycosaminoglycan metabolic process GO:0030203 8.96 XYLT1 XYLT2
6 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.62 XYLT1 XYLT2

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.16 XYLT1 XYLT2
2 acetylglucosaminyltransferase activity GO:0008375 8.96 XYLT1 XYLT2
3 protein xylosyltransferase activity GO:0030158 8.62 XYLT1 XYLT2

Sources for Angioid Streaks

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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