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MCID: ANG004
MIFTS: 39

Angioid Streaks

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angioid Streaks

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MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 56 12 54 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13401
OMIM 56 607140
MeSH 43 D000793
MedGen 41 C0002982
UMLS 71 C0002982
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Summaries for Angioid Streaks

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MalaCards based summary : Angioid Streaks is related to pseudoxanthoma elasticum and yemenite deaf-blind hypopigmentation syndrome. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways are Endochondral Ossification and NOTCH1 regulation of human endothelial cell calcification. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and bone, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 74 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch's membrane, an... more...

More information from OMIM: 607140
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Related Diseases for Angioid Streaks

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Diseases related to Angioid Streaks via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 pseudoxanthoma elasticum 30.7 XYLT2 XYLT1 VEGFA MGP GGCX ENPP1
2 yemenite deaf-blind hypopigmentation syndrome 30.4 VEGFA CFH
3 arterial calcification of infancy 30.3 MGP GGCX GALNT3 ENPP1 AHSG ABCC6
4 multifocal choroiditis 30.3 CFH ARMS2
5 central serous chorioretinopathy 30.3 CFH ARMS2
6 histoplasmosis 30.2 CFH ARMS2
7 macular degeneration, age-related, 1 30.1 VEGFA ELN CFHR2 CFH ARMS2
8 choroiditis 30.0 VEGFA CFH ARMS2
9 connective tissue disease 29.9 VEGFA ELN CFHR2 ABCC6
10 kuhnt-junius degeneration 29.6 VEGFA CFHR2 CFH ARMS2
11 eye disease 29.3 VEGFA CFHR2 CFH ARMS2 ABCC6
12 fundus dystrophy 29.1 VEGFA ELN CFHR2 CFH ARMS2
13 calcinosis 28.9 MGP GALNT3 ENPP1 AHSG
14 kidney disease 28.7 VEGFA MGP ENPP1 CFH AHSG
15 angioid streaks of choroid 12.5
16 tumoral calcinosis, hyperphosphatemic, familial, 1 11.8
17 anemia, congenital dyserythropoietic, type iii 11.7
18 mammary paget's disease 10.7
19 thalassemia 10.6
20 optic disk drusen 10.6
21 hemoglobinopathy 10.6
22 ehlers-danlos syndrome 10.6
23 microvascular complications of diabetes 5 10.5
24 beta-thalassemia 10.5
25 sickle cell anemia 10.5
26 myopia 10.5
27 sickle cell disease 10.5
28 hereditary spherocytosis 10.4
29 abetalipoproteinemia 10.4
30 anemia, congenital dyserythropoietic, type ia 10.4
31 hyperphosphatemia 10.4
32 acromegaly 10.4
33 bone inflammation disease 10.4
34 paget's disease of bone 10.4
35 desbuquois dysplasia 10.3 XYLT2 XYLT1
36 elastosis perforans serpiginosa 10.3 ELN ABCC6
37 retinal detachment 10.3
38 sturge-weber syndrome 10.3
39 choroidal dystrophy, central areolar, 1 10.3
40 deficiency anemia 10.3
41 telangiectasis 10.3
42 retinal vein occlusion 10.3
43 vascular disease 10.3
44 epilepsy 10.3
45 central retinal vein occlusion 10.3
46 chorioretinitis 10.3
47 familial tumoral calcinosis 10.3
48 weber syndrome 10.3
49 angiomatosis 10.3
50 blepharochalasis 10.1 LAX1 ELN

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks
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Symptoms & Phenotypes for Angioid Streaks

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Clinical features from OMIM:

607140

MGI Mouse Phenotypes related to Angioid Streaks:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ABCC6 CDAN1 CFH ENPP1 GALNT3 GGCX
2 growth/size/body region MP:0005378 9.85 ABCC6 AHSG CDAN1 CFH ENPP1 GALNT3
3 muscle MP:0005369 9.43 AHSG CFH ENPP1 GALNT3 MGP VEGFA
4 renal/urinary system MP:0005367 9.17 ABCC6 CFH ENPP1 GALNT3 MGP VEGFA
Sources

Drugs & Therapeutics for Angioid Streaks

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Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3
Magnesium oxide Approved Phase 2 1309-48-4 14792
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5 Endothelial Growth Factors Phase 2
6 Mitogens Phase 2
7 Gastrointestinal Agents Phase 2
8 Anti-Ulcer Agents Phase 2
9 Magnesium Supplement Phase 2
10 Antacids Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
2 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
3 OCT, Visual Outcome and Angiographic Analysis of Choroidal Neovascularization in Six Eyes With Angioid Streaks Treated With a Single Intravitreal Injection of Bevacizumab Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
4 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
5 Intravitreal Aflibercept (Eylea) for Therapy of Choroidal Neovascularization (CNV) and Fibrovascular Proliferation (FVP) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT02537054 Phase 2 Aflibercept
6 Ranibizumab in Choroidal Neovascularization (CNV) Due to Pseudoxanthoma Elasticum (PXE, Groenblad-Strandberg-Syndrome) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
7 Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) Completed NCT01525875 Phase 2 Magnesium Oxide;Placebo
8 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
9 Ranibizumab Therapy for Choroidal Neovascularization Associated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
10 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients. Withdrawn NCT02573038 Phase 2 Aflibercept
11 Intravitreal Bevacizumab for Choroidal Neovascularization Secondary to Angioid Streaks: 24 Months Follow-up Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
12 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
13 Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy Completed NCT00803517
14 Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Angioid Streaks Recruiting NCT04119219
15 Evaluation of Choroidal Thickness in Patients Suffering From Beta-thalassemia Recruiting NCT04067258
16 Characterization of Patients With Pseudoxanthoma Elasticum Active, not recruiting NCT02108392
17 Pilot Study of Intravitreal Bevacizumab vs. Combination Therapy for Choroidal Neovascularization Secondary to Causes Other Than Age-related Macular Degeneration Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

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Genetic Tests for Angioid Streaks

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Anatomical Context for Angioid Streaks

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MalaCards organs/tissues related to Angioid Streaks:

40
Retina, Eye, Bone, Endothelial, Skin, Pituitary, Kidney
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Publications for Angioid Streaks

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Articles related to Angioid Streaks:

(show top 50) (show all 607)
# Title Authors PMID Year
1
Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. 61 56
12208247 2002
2
Angioid streaks associated with abetalipoproteinemia. 61 56
7749670 1994
3
Angioid streaks in homozygous beta thalassemia. 61 56
2801854 1989
4
Angioid streaks. 61 56
7046115 1982
5
Angioid streaks in Ehlers-Danlos syndrome. 61 56
5945174 1966
6
Angioid streaks and sicklecell disease. 61 56
13827077 1960
7
Effect of large oral doses of vitamin E on the neurological sequelae of patients with abetalipoproteinemia. 56
6959555 1982
8
Novel mutations of ABCC6 gene in Japanese patients with Angioid streaks. 54 61
19284998 2009
9
[What can we learn from molecular genetic analyses of inherited eye diseases?]. 54 61
17134037 2006
10
[Mendelian arterial diseases. Pseudoxanthoma elasticum, Ehlers-Danlos vascular syndrome, Rendu-Osler disease]. 54 61
14694786 2003
11
Optic disc drusen, angioid streaks, and mottled fundus in various combinations in a Sicilian family. 54 61
12271376 2002
12
Aflibercept for choroidal neovascularizations secondary to pseudoxanthoma elasticum: a prospective study. 61
31863395 2020
13
Identification of hyperreflective foci in angioid streaks. 61
31278381 2019
14
Angioid Streaks and Other Retinopathy in Pseudoxanthoma Elasticum. 61
31600377 2019
15
Confirmation That Angioid Streaks Are Not Common in Ehlers-Danlos Syndrome. 61
31556922 2019
16
A rare case of focal choroidal excavation associated choroidal neovascularization in angioid streaks. 61
31902999 2019
17
[Ocular manifestations in Ehlers-Danlos Syndromes: Clinical study of 21 patients]. 61
31133401 2019
18
Retinal sensitivity in angioid streaks. 61
31044269 2019
19
One-year outcomes of anti-vascular endothelial growth factor therapy in peripapillary choroidal neovascularisation. 61
31401554 2019
20
Acute Retinopathy in Pseudoxanthoma Elasticum. 61
31393536 2019
21
[Angioid streaks in systemic disease]. 61
31203643 2019
22
Evaluation of lamina cribrosa in angioid streaks using spectral-domain optical coherence tomography enhanced depth imaging. 61
31101364 2019
23
Coquille d'oeuf in young patients affected with Pseudoxantoma elasticum. 61
31269855 2019
24
Unexpected ABCC6 mRNA splicing in a Chinese family with pseudoxanthoma elasticum. 61
30328268 2019
25
Angioid streaks in pseudoxanthoma elasticum. 61
30580324 2019
26
Retinal findings in carriers of monoallelic ABCC6 mutations. 61
30923132 2019
27
Angioid Streaks Are Not a Common Feature of Ehlers-Danlos Syndrome. 61
30543351 2019
28
Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks. 61
30250237 2019
29
Switching from ranibizumab to aflibercept in choroidal neovascularization secondary to angioid streaks. 61
30880436 2019
30
Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population-the Bridlington eye assessment project (BEAP): a cross-sectional study (2002-2006). 61
30315265 2019
31
Anti-VEGF treatment for choroidal neovascularization complicating pattern dystrophy-like deposit associated with pseudoxanthoma elasticum. 61
30470876 2019
32
Choroidal Neovascularization Resulting from Angioid Streaks in Pseudoxanthoma Elasticum. 61
30929814 2019
33
Ranibizumab for the treatment of choroidal neovascularization due to cause other than age related macular degeneration. 61
31779462 2019
34
ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. 61
30260918 2019
35
LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES. 61
30608346 2018
36
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. 61
28961674 2018
37
[Angioid streaks in a 33-year-old man with β-Thalassemia]. 61
30224095 2018
38
PNEUMATIC COMPACTION TREATMENT OF ACUTE SUBFOVEAL HEMORRHAGE AFTER BLUNT TRAUMA IN A PATIENT WITH ANGIOID STREAKS ASSOCIATED WITH PSEUDOXANTHOMA ELASTICUM. 61
30300312 2018
39
[Study of fundus examination by age in 158 pseudoxanthoma elasticum patients]. 61
30143311 2018
40
[Choroidal Neovascularisation Other than Typical Neovascular Age-Related Macular Degeneration]. 61
28282700 2018
41
PSEUDOXANTHOMA ELASTICUM: SUCCESSFUL LONG-TERM MANAGEMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS WITH PRO RE NATA INTRAVITREAL BEVACIZUMAB INJECTIONS. 61
30048402 2018
42
ABCC6 mutations and early onset stroke: Two cases of a typical Pseudoxanthoma Elasticum. 61
29709427 2018
43
Hyperreflective Foci Number Correlates with Choroidal Neovascularization Activity in Angioid Streaks. 61
30025095 2018
44
BILATERAL CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH BETA-THALASSEMIA MAJOR AND ITS MANAGEMENT. 61
27768638 2018
45
Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks. 61
29687087 2018
46
MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA ELASTICUM. 61
29965887 2018
47
Reticular Pseudodrusen and Thin Choroid Are Associated With Angioid Streaks. 61
29927467 2018
48
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks. 61
29802262 2018
49
To laser or not? 61
29480271 2018
50
[Post-traumatic macular hematoma as presenting sign of angioid streaks: Role of spectral-domain optical coherence tomography (SD-OCT)]. 61
29395597 2018
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Variations for Angioid Streaks

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Expression for Angioid Streaks

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Search GEO for disease gene expression data for Angioid Streaks.
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Pathways for Angioid Streaks

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Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endochondral Ossification 1
10.61 VEGFA MGP ENPP1
2
NOTCH1 regulation of human endothelial cell calcification 1
10.41 VEGFA MGP
3
Warfarin Pathway, Pharmacodynamics 60
10.13 MGP GGCX
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GO Terms for Angioid Streaks

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Cellular components related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 XYLT2 XYLT1 VEGFA MGP ENPP1 ELN

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of insulin receptor signaling pathway GO:0046627 9.43 ENPP1 AHSG
2 chondroitin sulfate biosynthetic process GO:0030206 9.4 XYLT2 XYLT1
3 proteoglycan biosynthetic process GO:0030166 9.37 XYLT2 XYLT1
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.32 XYLT2 XYLT1
5 negative regulation of bone mineralization GO:0030502 9.26 ENPP1 AHSG
6 glycosaminoglycan metabolic process GO:0030203 9.16 XYLT2 XYLT1
7 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.96 XYLT2 XYLT1
8 regulation of bone mineralization GO:0030500 8.8 MGP ENPP1 AHSG

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.96 VEGFA ELN
2 protein xylosyltransferase activity GO:0030158 8.62 XYLT2 XYLT1
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Sources for Angioid Streaks

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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