Aliases & Classifications for Angioid Streaks

MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 57 12 55 44 15 73

Classifications:



External Ids:

OMIM 57 607140
Disease Ontology 12 DOID:13401
MeSH 44 D000793
MedGen 42 C0002982
UMLS 73 C0002982

Summaries for Angioid Streaks

MalaCards based summary : Angioid Streaks is related to pseudoxanthoma elasticum and angioid streaks of choroid. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotype is renal/urinary system.

Wikipedia : 76 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch\'s membrane, an... more...

Description from OMIM: 607140

Related Diseases for Angioid Streaks

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks

Symptoms & Phenotypes for Angioid Streaks

Clinical features from OMIM:

607140

MGI Mouse Phenotypes related to Angioid Streaks:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 ABCC6 GALNT3 VEGFA XYLT2

Drugs & Therapeutics for Angioid Streaks

Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 1,Not Applicable 216974-75-3
2 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
3 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1,Not Applicable
4
Ranibizumab Approved Phase 2,Phase 1 347396-82-1 459903
5 Endothelial Growth Factors Phase 2
6 Mitogens Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
2 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
3 Ranibizumab to Treat Choroidal Neovascularization (CNV) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
4 Intravitreal Aflibercept for Therapy of Patients With Pseudoxanthoma Elasticum (PXE) Active, not recruiting NCT02537054 Phase 2 Aflibercept
5 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients (ASTRID). Withdrawn NCT02573038 Phase 2 Aflibercept
6 Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
7 Intravitreal Bevacizumab in Agioid Streaks Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
8 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
9 Characterization of Pseudoxanthoma Elasticum Active, not recruiting NCT02108392
10 Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD Withdrawn NCT01256580 Not Applicable Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

Genetic Tests for Angioid Streaks

Anatomical Context for Angioid Streaks

MalaCards organs/tissues related to Angioid Streaks:

41
Retina, Eye, Endothelial, Pituitary, Skin, Bone, Cervix

Publications for Angioid Streaks

Articles related to Angioid Streaks:

(show top 50) (show all 264)
# Title Authors Year
1
Reticular Pseudodrusen and Thin Choroid Are Associated With Angioid Streaks. ( 29927467 )
2018
2
Corneal biomechanical properties are associated with the activity and prognosis of Angioid Streaks. ( 29802262 )
2018
3
Central serous chorioretinopathy with angioid streaks: a rare combination. ( 29623251 )
2018
4
MULTIMODAL IMAGING OF FOCAL CHOROIDAL EXCAVATION COMPLICATED BY CHOROIDAL NEOVASCULARIZATION IN A PATIENT WITH ANGIOID STREAKS AND PSEUDOXANTHOMA ELASTICUM. ( 29965887 )
2018
5
MULTIMODAL IMAGING OF ANGIOID STREAKS ASSOCIATED WITH TURNER SYNDROME. ( 29443807 )
2018
6
Multimodal imaging characteristics of quiescent type 1 neovascularization in an eye with angioid streaks. ( 29687087 )
2018
7
Long-term follow-up of patients with choroidal neovascularization due to angioid streaks. ( 28031699 )
2017
8
Intravitreal Bevacizumab for Choroidal Neovascularization Associated with Angioid Streaks: Long-term Results. ( 29279654 )
2017
9
ABCC6 Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance. ( 28912966 )
2017
10
Optical coherence tomography analysis of evolution of Bruch's membrane features in angioid streaks. ( 28622313 )
2017
11
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. ( 28961674 )
2017
12
Angioid streaks in a case of Camurati-Engelmann disease. ( 28724827 )
2017
13
Detection of nonexudative choroidal neovascularization secondary to angioid streaks using optical coherence tomography angiography. ( 28574138 )
2017
14
Long-Term Follow-Up of Choroidal Neovascularization due to Angioid Streaks with pro re nata Intravitreal Anti-VEGF Treatment. ( 28641290 )
2017
15
Long-Term Follow-Up of Polypoidal Choroidal Vasculopathy Secondary to Angioid Streaks Treated by Intravitreal Aflibercept and Ranibizumab. ( 28512425 )
2017
16
Multiple Choroidal Ruptures in a Patient With Angioid Streaks. ( 28278344 )
2017
17
Intravitreal ranibizumab for choroidal neovascularization in a patient with angioid streaks and multiple evanescent white dots. ( 27457484 )
2016
18
Intravitreal aflibercept for refractory choroidal neovascularization secondary to angioid streaks. ( 26939555 )
2016
19
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26795411 )
2016
20
The effect of the acceleration/deceleration trauma in angioid streaks: A pathogenic hypothesis. ( 27021800 )
2016
21
Angioid streaks in aagenaes syndrome. ( 27614462 )
2016
22
Treat and extend regimen with aflibercept for choroidal neovascularization in angioid streaks. ( 26795418 )
2016
23
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26939557 )
2016
24
Angioid Streaks in the Fundus of a 13-Year-Old Girl. ( 27697324 )
2016
25
Intravitreal Bevacizumab for Nonsubfoveal Choroidal Neovascularization Associated With Angioid Streaks: 3-Year Follow-up Study. ( 27013066 )
2016
26
Silent polypoidal choroidal vasculopathy in a patient with angioid streaks. ( 27463636 )
2016
27
Angioid streaks complicated by choroidal neovascularization in Paget's disease. ( 27587348 )
2016
28
Angioid Streaks in Types I and II Congenital Dyserythropoietic Anaemia (CDA). ( 27116514 )
2016
29
LOCATING AND CHARACTERIZING ANGIOID STREAKS WITH EN FACE OPTICAL COHERENCE TOMOGRAPHY. ( 27145173 )
2016
30
Drastic effect of ranibizumab on choroidal neovascularization in idiopathic angioid streaks. ( 26375345 )
2015
31
Intravitreal aflibercept for choroidal neovascularisation in angioid streaks. ( 26021869 )
2015
32
INTRAVITREAL BEVACIZUMAB IN THE TREATMENT OF CHOROIDAL NEOVASCULAR MEMBRANE DUE TO ANGIOID STREAKS. ( 25996427 )
2015
33
Angioid streaks in association with sickle thalassemia trait. ( 25569313 )
2015
34
Corneal Viscoelastic Properties in Patients with Angioid Streaks. ( 25942046 )
2015
35
INTRAVITREAL RANIBIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN ANGIOID STREAKS: Four-Year Follow-up. ( 26355947 )
2015
36
Intravitreal aflibercept for management of subfoveal choroidal neovascularization secondary to angioid streaks. ( 26458482 )
2015
37
UngewAPhnliche posttraumatische Netzhautblutungen zeigen Angioid Streaks. ( 25902130 )
2015
38
VISUAL RECOVERY AFTER AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROIDAL PATCH IN A PATIENT WITH CHOROIDAL NEOVASCULARIZATION SECONDARY TO ANGIOID STREAKS: LONG-TERM RESULTS. ( 26679062 )
2015
39
Peau d'orange and angioid streaks: manifestations of Bruch membrane pathology. ( 25526100 )
2015
40
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: a long-term follow-up study. ( 25044143 )
2014
41
Intravitreal bevacizumab for nonsubfoveal choroidal neovascularization associated with angioid streaks. ( 24211865 )
2014
42
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: A report of two patients. ( 25473350 )
2014
43
Successful long-term management of choroidal neovascularization secondary to angioid streaks in a patient with pseudoxanthoma elasticum: a case report. ( 25529762 )
2014
44
Intravitreal ranibizumab for bilateral choroidal neovascularisation in a patient with angioid streaks. ( 25073527 )
2014
45
Subretinal neovascular membrane in angioid streaks treated with intravitreal bevacizumab. ( 24269464 )
2013
46
Treatment of choroidal neovascularization due to angioid streaks: a comprehensive review. ( 23719398 )
2013
47
Choroidal neovascularization in a case of angioid streaks. ( 24008786 )
2013
48
The time course changes of choroidal neovascularization in angioid streaks. ( 23114408 )
2013
49
Acute stroke after intravitreal bevacizumab to treat choroidal neovascularization due to angioid streaks in pseudoxanthoma elasticum : a severe systemic adverse event after an off-label procedure. ( 23065017 )
2013
50
Choroidal neovascularization in angioid streaks following microincision vitrectomy surgery: a case report. ( 23829451 )
2013

Variations for Angioid Streaks

Expression for Angioid Streaks

Search GEO for disease gene expression data for Angioid Streaks.

Pathways for Angioid Streaks

Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 XYLT1 XYLT2

GO Terms for Angioid Streaks

Cellular components related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 8.8 GALNT3 XYLT1 XYLT2

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycosaminoglycan biosynthetic process GO:0006024 9.26 XYLT1 XYLT2
2 glycosaminoglycan metabolic process GO:0030203 9.16 XYLT1 XYLT2
3 chondroitin sulfate biosynthetic process GO:0030206 8.96 XYLT1 XYLT2
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 8.62 XYLT1 XYLT2

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acetylglucosaminyltransferase activity GO:0008375 9.16 XYLT1 XYLT2
2 transferase activity, transferring glycosyl groups GO:0016757 9.13 GALNT3 XYLT1 XYLT2
3 protein xylosyltransferase activity GO:0030158 8.62 XYLT1 XYLT2

Sources for Angioid Streaks

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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