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MCID: ANG004
MIFTS: 39

Angioid Streaks

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angioid Streaks

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MalaCards integrated aliases for Angioid Streaks:

Name: Angioid Streaks 56 12 29 54 43 15 17 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13401
OMIM 56 607140
MeSH 43 D000793
MedGen 41 C0002982
UMLS 71 C0002982
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Summaries for Angioid Streaks

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MalaCards based summary : Angioid Streaks is related to arterial calcification of infancy and retinal detachment. An important gene associated with Angioid Streaks is ABCC6 (ATP Binding Cassette Subfamily C Member 6), and among its related pathways/superpathways are Endochondral Ossification and Ubiquinol biosynthesis. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotypes are cardiovascular system and renal/urinary system

Wikipedia : 74 Angioid streaks, also called Knapp streaks or Knapp striae are small breaks in Bruch's membrane, an... more...

More information from OMIM: 607140
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Related Diseases for Angioid Streaks

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Diseases related to Angioid Streaks via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 arterial calcification of infancy 31.0 MGP GGCX GALNT3 ENPP1 ABCC6
2 retinal detachment 30.5 XYLT2 VEGFA ELN
3 yemenite deaf-blind hypopigmentation syndrome 30.4 VEGFA CFH
4 multifocal choroiditis 30.3 CFH ARMS2
5 central serous chorioretinopathy 30.3 CFH ARMS2
6 pseudoxanthoma elasticum 30.3 XYLT2 XYLT1 VKORC1 VEGFA MGP GGCX
7 macular degeneration, age-related, 1 30.0 VEGFA ELN CFHR2 CFH ARMS2
8 histoplasmosis 30.0 CFH ARMS2
9 choroiditis 30.0 VEGFA CFH ARMS2
10 connective tissue disease 29.9 VEGFA ELN CFHR2 ABCC6
11 kuhnt-junius degeneration 29.6 VEGFA CFHR2 CFH ARMS2
12 calcinosis 29.6 MGP GALNT3 ENPP1
13 eye disease 29.3 VEGFA CFHR2 CFH ARMS2 ABCC6
14 fundus dystrophy 29.1 VEGFA ELN CFHR2 CFH ARMS2
15 angioid streaks of choroid 12.6
16 tumoral calcinosis, hyperphosphatemic, familial, 1 11.8
17 anemia, congenital dyserythropoietic, type iii 11.8
18 mammary paget's disease 10.7
19 thalassemia 10.6
20 optic disk drusen 10.6
21 hemoglobinopathy 10.6
22 ehlers-danlos syndrome 10.6
23 microvascular complications of diabetes 5 10.5
24 beta-thalassemia 10.5
25 sickle cell anemia 10.5
26 joint laxity, short stature, and myopia 10.5
27 myopia 10.5
28 sickle cell disease 10.5
29 hereditary spherocytosis 10.4
30 larsen-like syndrome b3gat3 type 10.4 XYLT2 XYLT1
31 abetalipoproteinemia 10.4
32 anemia, congenital dyserythropoietic, type ia 10.4
33 hyperphosphatemia 10.4
34 acromegaly 10.4
35 bone inflammation disease 10.4
36 paget's disease of bone 10.4
37 desbuquois dysplasia 10.3 XYLT2 XYLT1
38 elastosis perforans serpiginosa 10.3 ELN ABCC6
39 sturge-weber syndrome 10.3
40 choroidal dystrophy, central areolar, 1 10.3
41 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.3
42 telangiectasis 10.3
43 retinal vein occlusion 10.3
44 vascular disease 10.3
45 epilepsy 10.3
46 optic nerve disease 10.3
47 central retinal vein occlusion 10.3
48 chorioretinitis 10.3
49 familial tumoral calcinosis 10.3
50 weber syndrome 10.3

Graphical network of the top 20 diseases related to Angioid Streaks:



Diseases related to Angioid Streaks
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Symptoms & Phenotypes for Angioid Streaks

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Clinical features from OMIM:

607140

MGI Mouse Phenotypes related to Angioid Streaks:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 ABCC6 CDAN1 CFH ENPP1 GALNT3 GGCX
2 renal/urinary system MP:0005367 9.17 ABCC6 CFH ENPP1 GALNT3 MGP VEGFA
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Drugs & Therapeutics for Angioid Streaks

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Drugs for Angioid Streaks (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3
Magnesium oxide Approved Phase 2 1309-48-4 14792
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5 Mitogens Phase 2
6 Endothelial Growth Factors Phase 2
7 Gastrointestinal Agents Phase 2
8 Antacids Phase 2
9 Anti-Ulcer Agents Phase 2
10 Magnesium Supplement Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
2 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
3 OCT, Visual Outcome and Angiographic Analysis of Choroidal Neovascularization in Six Eyes With Angioid Streaks Treated With a Single Intravitreal Injection of Bevacizumab Unknown status NCT00599820 Phase 3 Intravitreal Bevacizumab
4 Effect of Intravitreal Bevacizumab on Non -Age-Related Macular Degeneration (AMD) Related Choroidal Neovascularization (CNV) Completed NCT00370786 Phase 3 bevacizumab
5 Intravitreal Aflibercept (Eylea) for Therapy of Choroidal Neovascularization (CNV) and Fibrovascular Proliferation (FVP) in Patients With Pseudoxanthoma Elasticum (PXE) Completed NCT02537054 Phase 2 Aflibercept
6 Ranibizumab in Choroidal Neovascularization (CNV) Due to Pseudoxanthoma Elasticum (PXE, Groenblad-Strandberg-Syndrome) Completed NCT00510965 Phase 2 Intravitreal injection ranibizumab
7 Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) Completed NCT01525875 Phase 2 Magnesium Oxide;Placebo
8 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
9 Ranibizumab Therapy for Choroidal Neovascularization Associated With Angioid Streaks Withdrawn NCT01015495 Phase 1, Phase 2 ranibizumab
10 Phase II Study Evaluating the Efficacy of Aflibercept for the Treatment of Choroidal Neovascularization in Angioid Streaks in Young Patients. Withdrawn NCT02573038 Phase 2 Aflibercept
11 Intravitreal Bevacizumab for Choroidal Neovascularization Secondary to Angioid Streaks: 24 Months Follow-up Completed NCT00406250 Phase 1 intravitreal injection;intravitreal injection
12 Characterization of Patients With Pseudoxanthoma Elasticum Unknown status NCT02108392
13 Evolution of Visual Impairment During Pseudoxanthoma Elasticum Completed NCT00555113
14 Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy Completed NCT00803517
15 Collaborative Ocular Antiangiogenic Study of Ukraine. Multicentral, Open-label, Randomized, Prospective Study of Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Angioid Streaks Recruiting NCT04119219
16 Evaluation of Choroidal Thickness in Patients Suffering From Beta-thalassemia Recruiting NCT04067258
17 Pilot Study of Intravitreal Bevacizumab vs. Combination Therapy for Choroidal Neovascularization Secondary to Causes Other Than Age-related Macular Degeneration Withdrawn NCT01256580 Bevacizumab (Avastin; Genentech, Inc.);Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy

Search NIH Clinical Center for Angioid Streaks

Cochrane evidence based reviews: angioid streaks

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Genetic Tests for Angioid Streaks

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Genetic tests related to Angioid Streaks:

# Genetic test Affiliating Genes
1 Angioid Streaks 29
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Anatomical Context for Angioid Streaks

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MalaCards organs/tissues related to Angioid Streaks:

40
Retina, Eye, Endothelial, Skin, Pituitary, Bone, Brain
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Publications for Angioid Streaks

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Articles related to Angioid Streaks:

(show top 50) (show all 619)
# Title Authors PMID Year
1
Photodynamic therapy with verteporfin for choroidal neovascularization in patients with angioid streaks. 56 61
12208247 2002
2
Angioid streaks associated with abetalipoproteinemia. 61 56
7749670 1994
3
Angioid streaks in homozygous beta thalassemia. 61 56
2801854 1989
4
Angioid streaks. 61 56
7046115 1982
5
Angioid streaks in Ehlers-Danlos syndrome. 61 56
5945174 1966
6
Angioid streaks and sicklecell disease. 56 61
13827077 1960
7
Effect of large oral doses of vitamin E on the neurological sequelae of patients with abetalipoproteinemia. 56
6959555 1982
8
Novel mutations of ABCC6 gene in Japanese patients with Angioid streaks. 54 61
19284998 2009
9
[What can we learn from molecular genetic analyses of inherited eye diseases?]. 61 54
17134037 2006
10
[Mendelian arterial diseases. Pseudoxanthoma elasticum, Ehlers-Danlos vascular syndrome, Rendu-Osler disease]. 61 54
14694786 2003
11
Optic disc drusen, angioid streaks, and mottled fundus in various combinations in a Sicilian family. 54 61
12271376 2002
12
Pseudoxanthoma elasticum and angioid streaks. 61
32502256 2020
13
Bilateral angioid streaks with choroidal neovascular membranes. 61
32156486 2020
14
Intravitreal aflibercept for management of choroidal neovascularization secondary to angioid streaks: The Italian EYLEA-STRIE study. 61
32483995 2020
15
Switching from ranibizumab to aflibercept in choroidal neovascularization secondary to angioid streaks. 61
30880436 2020
16
Retinal Pigment Epithelium Activation in Angioid Streaks Imaged With En Face Optical Coherence Tomography. 61
32453065 2020
17
Long-term follow-up of management of choroidal neovascularisation secondary to angioid streaks with intravitreal anti-vascular endothelial growth factor. 61
32461565 2020
18
One-year outcomes of anti-vascular endothelial growth factor therapy in peripapillary choroidal neovascularisation. 61
31401554 2020
19
Long-term results of choroidal neovascularization secondary to angioid streaks. 61
32472199 2020
20
Visual Dermatology: Cobblestone Skin, Angioid Streaks, and Gastrointestinal Hemorrhage. 61
32421427 2020
21
Late-onset Pseudoxanthoma Elasticum Associated with a Hypomorphic ABCC6 Variant. 61
32442430 2020
22
Tomographic characteristics of focal choroidal excavation and its association with retinal disorders. 61
32452223 2020
23
Angioid streaks and obstructive sleep apnea syndrome: are they related? 61
32301031 2020
24
Giant Idiopathic Angioid Streaks. 61
32308959 2020
25
LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES. 61
30608346 2020
26
IS VAGINAL DELIVERY HARMFUL TO PATIENTS WITH PSEUDOXANTHOMA ELASTICUM? 61
32205712 2020
27
Aflibercept for choroidal neovascularizations secondary to pseudoxanthoma elasticum: a prospective study. 61
31863395 2020
28
Identification of hyperreflective foci in angioid streaks. 61
31278381 2019
29
Angioid Streaks and Other Retinopathy in Pseudoxanthoma Elasticum. 61
31600377 2019
30
Confirmation That Angioid Streaks Are Not Common in Ehlers-Danlos Syndrome. 61
31556922 2019
31
A rare case of focal choroidal excavation associated choroidal neovascularization in angioid streaks. 61
31902999 2019
32
[Ocular manifestations in Ehlers-Danlos Syndromes: Clinical study of 21 patients]. 61
31133401 2019
33
Retinal sensitivity in angioid streaks. 61
31044269 2019
34
Acute Retinopathy in Pseudoxanthoma Elasticum. 61
31393536 2019
35
[Angioid streaks in systemic disease]. 61
31203643 2019
36
Evaluation of lamina cribrosa in angioid streaks using spectral-domain optical coherence tomography enhanced depth imaging. 61
31101364 2019
37
Coquille d'oeuf in young patients affected with Pseudoxantoma elasticum. 61
31269855 2019
38
Unexpected ABCC6 mRNA splicing in a Chinese family with pseudoxanthoma elasticum. 61
30328268 2019
39
Angioid streaks in pseudoxanthoma elasticum. 61
30580324 2019
40
Retinal findings in carriers of monoallelic ABCC6 mutations. 61
30923132 2019
41
Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks. 61
30250237 2019
42
Angioid Streaks Are Not a Common Feature of Ehlers-Danlos Syndrome. 61
30543351 2019
43
Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population-the Bridlington eye assessment project (BEAP): a cross-sectional study (2002-2006). 61
30315265 2019
44
Anti-VEGF treatment for choroidal neovascularization complicating pattern dystrophy-like deposit associated with pseudoxanthoma elasticum. 61
30470876 2019
45
Ranibizumab for the treatment of choroidal neovascularization due to cause other than age related macular degeneration. 61
31779462 2019
46
Choroidal Neovascularization Resulting from Angioid Streaks in Pseudoxanthoma Elasticum. 61
30929814 2019
47
ANGIOID STREAKS: A Comprehensive Review From Pathophysiology to Treatment. 61
30260918 2019
48
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF ANGIOID STREAKS. 61
28961674 2018
49
[Angioid streaks in a 33-year-old man with β-Thalassemia]. 61
30224095 2018
50
PNEUMATIC COMPACTION TREATMENT OF ACUTE SUBFOVEAL HEMORRHAGE AFTER BLUNT TRAUMA IN A PATIENT WITH ANGIOID STREAKS ASSOCIATED WITH PSEUDOXANTHOMA ELASTICUM. 61
30300312 2018
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Variations for Angioid Streaks

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Expression for Angioid Streaks

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Search GEO for disease gene expression data for Angioid Streaks.
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Pathways for Angioid Streaks

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Pathways related to Angioid Streaks according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endochondral Ossification 1
10.94 VEGFA MGP ENPP1
2
Ubiquinol biosynthesis 65
Show member pathways
 10.62 VKORC1 GGCX
3
NOTCH1 regulation of human endothelial cell calcification 1
10.41 VEGFA MGP
4
Warfarin Pathway, Pharmacodynamics 60
9.98 VKORC1 MGP GGCX
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GO Terms for Angioid Streaks

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Cellular components related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 XYLT2 XYLT1 VEGFA MGP ENPP1 ELN

Biological processes related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chondroitin sulfate biosynthetic process GO:0030206 9.4 XYLT2 XYLT1
2 regulation of bone mineralization GO:0030500 9.37 MGP ENPP1
3 proteoglycan biosynthetic process GO:0030166 9.32 XYLT2 XYLT1
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.26 XYLT2 XYLT1
5 glycosaminoglycan metabolic process GO:0030203 9.16 XYLT2 XYLT1
6 chondroitin sulfate proteoglycan biosynthetic process GO:0050650 8.96 XYLT2 XYLT1
7 peptidyl-glutamic acid carboxylation GO:0017187 8.62 VKORC1 GGCX

Molecular functions related to Angioid Streaks according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.96 VEGFA ELN
2 protein xylosyltransferase activity GO:0030158 8.62 XYLT2 XYLT1
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Sources for Angioid Streaks

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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