MCID: ANG016
MIFTS: 41

Angiokeratoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma

MalaCards integrated aliases for Angiokeratoma:

Name: Angiokeratoma 12 29 55 44 15 73
Angiokeratoma of Skin 12 73
Cutaneous Angiokeratoma 12
Skin Angiokeratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:479
MeSH 44 D000794
NCIt 50 C2874 C4488
SNOMED-CT 68 26810009

Summaries for Angiokeratoma

MalaCards based summary : Angiokeratoma, also known as angiokeratoma of skin, is related to fabry disease and fucosidosis. An important gene associated with Angiokeratoma is NAGA (Alpha-N-Acetylgalactosaminidase), and among its related pathways/superpathways are Innate Immune System and Lysosome. Affiliated tissues include skin, tongue and kidney, and related phenotypes are behavior/neurological and cellular

Wikipedia : 76 Angiokeratoma is a benign cutaneous lesion of capillaries, resulting in small marks of red to blue color... more...

Related Diseases for Angiokeratoma

Diseases related to Angiokeratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 fabry disease 32.6 AGA FUCA1 GLA NAGA
2 fucosidosis 31.8 AGA CTSA FUCA1 NAGA
3 mannosidosis, beta a, lysosomal 31.7 CTSA MANBA NAGA
4 mannosidosis 30.0 MANBA NAGA
5 neuraminidase deficiency 29.7 CTSA NAGA
6 gangliosidosis gm1 29.6 CTSA GLA
7 aspartylglucosaminuria 29.2 AGA CTSA NAGA
8 angiokeratoma of fordyce 12.3
9 angiokeratoma circumscriptum 12.3
10 vulvar angiokeratoma 12.2
11 angiokeratoma of mibelli 12.2
12 angiokeratoma corporis diffusum with arteriovenous fistulas 12.1
13 kanzaki disease 11.7
14 galactosialidosis 11.6
15 schindler disease 11.5
16 mccallum macadam johnston syndrome 11.4
17 cobb syndrome 11.2
18 schindler disease, type i 11.0
19 melanoma 10.2
20 hemangioma 10.1
21 varicocele 10.1
22 verrucous hemangioma 10.1
23 cerebral cavernous malformations 10.0
24 granuloma annulare 10.0
25 penile cancer 10.0
26 lymphangioma 10.0
27 squamous cell carcinoma 10.0
28 necrobiosis lipoidica 10.0
29 gangliosidosis gm2 9.9 CTSA NAGA
30 mannosidosis, alpha b, lysosomal 9.9 CTSA MANBA
31 scheie syndrome 9.9 CTSA GLA
32 blue rubber bleb nevus 9.8
33 kaposi sarcoma 9.8
34 klippel-trenaunay-weber syndrome 9.8
35 nevus, epidermal 9.8
36 noonan syndrome 1 9.8
37 lymphoma, hodgkin, classic 9.8
38 mycosis fungoides 9.8
39 angioma serpiginosum, x-linked 9.8
40 myocardial infarction 9.8
41 childhood type dermatomyositis 9.8
42 lymphedema 9.8
43 lymphoma 9.8
44 dermatomyositis 9.8
45 sarcoma 9.8
46 anogenital venereal wart 9.8
47 diarrhea 9.8
48 syringoma 9.8
49 agammaglobulinemia 9.8
50 papilloma 9.8

Graphical network of the top 20 diseases related to Angiokeratoma:



Diseases related to Angiokeratoma

Symptoms & Phenotypes for Angiokeratoma

MGI Mouse Phenotypes related to Angiokeratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 AGA CTSA FUCA1 GLA MANBA
2 cellular MP:0005384 9.55 AGA CTSA FUCA1 GLA MANBA
3 liver/biliary system MP:0005370 9.26 AGA CTSA GLA MANBA
4 renal/urinary system MP:0005367 9.02 AGA CTSA FUCA1 GLA MANBA

Drugs & Therapeutics for Angiokeratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Patients With Fabry Disease Recruiting NCT02778295
2 Fabry's Disease and Pregnancy (PREFAB) Recruiting NCT02582294
3 Fabry Disease Registry Recruiting NCT00196742
4 Evaluation of Phenotypic Variability in Fabry Disease Not yet recruiting NCT03145779
5 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Angiokeratoma

Cochrane evidence based reviews: angiokeratoma

Genetic Tests for Angiokeratoma

Genetic tests related to Angiokeratoma:

# Genetic test Affiliating Genes
1 Angiokeratoma 29

Anatomical Context for Angiokeratoma

MalaCards organs/tissues related to Angiokeratoma:

41
Skin, Tongue, Kidney, Breast, Endothelial, Cervix, Skeletal Muscle

Publications for Angiokeratoma

Articles related to Angiokeratoma:

(show top 50) (show all 371)
# Title Authors Year
1
Dermoscopy of Angiokeratoma. ( 29644211 )
2018
2
Angiokeratoma corporis diffusum with normal enzyme activity: three new Italian cases. ( 29786951 )
2018
3
Solitary angiokeratoma of the vulva mimicking malignant melanoma. ( 29894537 )
2018
4
Angiokeratoma corporis diffusum mit normaler EnzymaktivitAot: drei neue FAolle aus Italien. ( 29873921 )
2018
5
Genital angiokeratoma in a woman with Fabry disease: the dermatologist's role. ( 29924222 )
2018
6
A subungual angiokeratoma with characteristic clinical and dermoscopic features. ( 29376508 )
2018
7
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. ( 30156622 )
2018
8
Acral pseudolymphomatous angiokeratoma of children (APACHE): Dermoscopic features and successful treatment with CO2 laser. ( 30192034 )
2018
9
Subungual Solitary Angiokeratoma Simulating a Squamous Cell Carcinoma. ( 30197892 )
2018
10
Solitary plaque on the leg of a child: A report of two cases and a brief review of acral pseudolymphomatous angiokeratoma of children and unilesional mycosis fungoides. ( 30318629 )
2018
11
Solitary angiokeratoma presenting as cutaneous horn. ( 28406536 )
2017
12
Angiokeratoma of Tongue. ( 28060116 )
2017
13
Acral pseudolymphomatous angiokeratoma of children with rainbow pattern: A mimicker of Kaposi sarcoma. ( 28087020 )
2017
14
Angiokeratoma of the Glans Penis. ( 29139361 )
2017
15
Unilateral angiokeratoma of the scrotum (Fordyce's type) associated with a contralateral varicocele. ( 28540880 )
2017
16
Rare Giant Angiokeratoma of the Vulva: A Case Report. ( 28418344 )
2017
17
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 28976126 )
2017
18
Acral angiokeratoma-like pseudolymphoma in a middle-aged woman. ( 28675468 )
2017
19
Solitary angiokeratoma with Meyerson phenomenon. ( 28087017 )
2017
20
Angiokeratoma corporis diffusum (Fabry disease) - A case report. ( 27727956 )
2016
21
Radiation-induced Vulvar Angiokeratoma Along with Other Late Radiation Toxicities after Carcinoma Cervix: A Rare Case Report. ( 27057045 )
2016
22
Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance. ( 27057048 )
2016
23
Angiokeratoma of the gluteal region in old age. ( 27694066 )
2016
24
Acral pseudolymphomatous angiokeratoma of children (APACHE)-like eruption in adult identical twins. ( 27663149 )
2016
25
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
26
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2016
27
Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study. ( 26371766 )
2016
28
Solitary Angiokeratoma: Report of Two Uncommon Cases. ( 26155544 )
2015
29
Multicentric study on the diagnosis of Fabry's disease using angiokeratoma biopsy registries. ( 25778427 )
2015
30
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. ( 26312700 )
2015
31
Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma. ( 25549813 )
2015
32
Familial angiokeratoma corporis diffusum without identified enzyme defect. ( 25566897 )
2015
33
An Extreme Case of Fordyce Angiokeratoma. ( 26099899 )
2015
34
Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy. ( 26436972 )
2015
35
In vivo characterization of solitary angiokeratoma by reflectance confocal microscopy and high definition optical coherence tomography. ( 25500039 )
2015
36
Angiokeratoma corporis diffusum. ( 25691205 )
2015
37
Angiokeratoma of Fordyce response to long pulsed Nd:YAG laser treatment. ( 26531316 )
2015
38
Thrombotic phenomena in angiokeratoma can evolve into spontaneous involution of the lesions: a report of two cases. ( 26395775 )
2015
39
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
40
A rare case of angiokeratoma in a 8-month-old boy. ( 25678595 )
2015
41
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 26259393 )
2015
42
Subungual angiokeratoma presenting as a longitudinal pigmented band in the nail. ( 25721145 )
2015
43
Solitary angiokeratoma of tongue: a rare entity clinically mistaken as a malignant tumor. ( 25118768 )
2014
44
A very rare case of vaginal angiokeratoma. ( 24984549 )
2014
45
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
46
Angiokeratoma of vulva mimicking genital warts. ( 25404845 )
2014
47
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
48
Eyelid angiokeratoma. ( 25100920 )
2014
49
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
50
Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE). ( 24628800 )
2014

Variations for Angiokeratoma

Expression for Angiokeratoma

Search GEO for disease gene expression data for Angiokeratoma.

Pathways for Angiokeratoma

Pathways related to Angiokeratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 AGA CTSA FUCA1 GLA MANBA
2 11.19 AGA CTSA FUCA1 GLA MANBA NAGA
3
Show member pathways
10.72 GLA NAGA
4 10.39 AGA FUCA1 MANBA

GO Terms for Angiokeratoma

Cellular components related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 CTSA FUCA1 GLA NAGA
2 lysosomal lumen GO:0043202 9.46 CTSA FUCA1 GLA MANBA
3 azurophil granule lumen GO:0035578 9.26 AGA CTSA FUCA1 GLA
4 lysosome GO:0005764 9.1 AGA CTSA FUCA1 GLA MANBA NAGA

Biological processes related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.62 FUCA1 GLA MANBA NAGA
2 metabolic process GO:0008152 9.46 FUCA1 GLA MANBA NAGA
3 glycosphingolipid metabolic process GO:0006687 9.43 CTSA GLA
4 oligosaccharide metabolic process GO:0009311 9.4 GLA NAGA
5 glycosylceramide catabolic process GO:0046477 9.37 GLA NAGA
6 neutrophil degranulation GO:0043312 9.35 AGA CTSA FUCA1 GLA MANBA
7 glycolipid catabolic process GO:0019377 9.26 FUCA1 NAGA
8 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.43 AGA CTSA FUCA1 GLA MANBA NAGA
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 GLA NAGA
3 alpha-galactosidase activity GO:0004557 9.16 GLA NAGA
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Angiokeratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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