MCID: ANG016
MIFTS: 41

Angiokeratoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma

MalaCards integrated aliases for Angiokeratoma:

Name: Angiokeratoma 12 56 45 15 74
Angiokeratoma of Skin 12 74
Cutaneous Angiokeratoma 12
Skin Angiokeratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:479
MeSH 45 D000794
NCIt 51 C2874 C4488
SNOMED-CT 69 26810009

Summaries for Angiokeratoma

MalaCards based summary : Angiokeratoma, also known as angiokeratoma of skin, is related to fabry disease and mannosidosis, beta a, lysosomal. An important gene associated with Angiokeratoma is NAGA (Alpha-N-Acetylgalactosaminidase), and among its related pathways/superpathways are Innate Immune System and Lysosome. Affiliated tissues include skin, tongue and kidney, and related phenotypes are behavior/neurological and cellular

Wikipedia : 77 Angiokeratoma is a benign cutaneous lesion of capillaries, resulting in small marks of red to blue color... more...

Related Diseases for Angiokeratoma

Diseases related to Angiokeratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 fabry disease 32.3 AGA FUCA1 GLA NAGA
2 mannosidosis, beta a, lysosomal 31.6 CTSA MANBA NAGA
3 fucosidosis 31.4 AGA CTSA FUCA1 NAGA
4 mannosidosis 30.0 MANBA NAGA
5 neuraminidase deficiency 29.5 CTSA NAGA
6 aspartylglucosaminuria 28.9 AGA CTSA NAGA
7 angiokeratoma of fordyce 12.4
8 angiokeratoma circumscriptum 12.3
9 vulvar angiokeratoma 12.3
10 angiokeratoma of mibelli 12.2
11 angiokeratoma corporis diffusum with arteriovenous fistulas 12.1
12 kanzaki disease 11.7
13 galactosialidosis 11.6
14 schindler disease 11.6
15 cobb syndrome 11.2
16 schindler disease, type i 11.1
17 melanoma 10.2
18 hemangioma 10.1
19 neutrophil migration 10.1
20 varicocele 10.1
21 verrucous hemangioma 10.1
22 cerebral cavernous malformations 10.0
23 granuloma annulare 10.0
24 penile cancer 10.0
25 lymphangioma 10.0
26 squamous cell carcinoma 10.0
27 necrobiosis lipoidica 10.0
28 lichen sclerosus 10.0
29 blue rubber bleb nevus 9.8
30 kaposi sarcoma 9.8
31 klippel-trenaunay-weber syndrome 9.8
32 nevus, epidermal 9.8
33 noonan syndrome 1 9.8
34 varicose veins 9.8
35 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.8
36 gm1-gangliosidosis, type i 9.8
37 lymphoma, hodgkin, classic 9.8
38 mycosis fungoides 9.8
39 angioma serpiginosum, x-linked 9.8
40 myocardial infarction 9.8
41 mucopolysaccharidosis-plus syndrome 9.8
42 cataract 9.8
43 childhood type dermatomyositis 9.8
44 human venous malformation 9.8
45 lymphedema 9.8
46 lymphoma 9.8
47 dermatomyositis 9.8
48 sarcoma 9.8
49 anogenital venereal wart 9.8
50 diarrhea 9.8

Graphical network of the top 20 diseases related to Angiokeratoma:



Diseases related to Angiokeratoma

Symptoms & Phenotypes for Angiokeratoma

MGI Mouse Phenotypes related to Angiokeratoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 AGA CTSA FUCA1 GLA MANBA
2 cellular MP:0005384 9.55 AGA CTSA FUCA1 GLA MANBA
3 liver/biliary system MP:0005370 9.26 AGA CTSA GLA MANBA
4 renal/urinary system MP:0005367 9.02 AGA CTSA FUCA1 GLA MANBA

Drugs & Therapeutics for Angiokeratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Biomarker for Patients With Fabry Disease (BioFabry) Recruiting NCT02778295
2 Fabry Disease Registry Recruiting NCT00196742
3 Evaluation of Phenotypic Variability in Fabry Disease Not yet recruiting NCT03145779
4 Fabry's Disease and Pregnancy (PREFAB) Terminated NCT02582294
5 Enzyme Replacement Therapy in Fabry Disease Terminated NCT00149318

Search NIH Clinical Center for Angiokeratoma

Cochrane evidence based reviews: angiokeratoma

Genetic Tests for Angiokeratoma

Anatomical Context for Angiokeratoma

MalaCards organs/tissues related to Angiokeratoma:

42
Skin, Tongue, Kidney, Breast, Endothelial, Skeletal Muscle, Cervix

Publications for Angiokeratoma

Articles related to Angiokeratoma:

(show top 50) (show all 373)
# Title Authors Year
1
Solitary plaque on the leg of a child: A report of two cases and a brief review of acral pseudolymphomatous angiokeratoma of children and unilesional mycosis fungoides. ( 30318629 )
2019
2
Sclerotherapy in Angiokeratoma of the Vulva: A Cost-Effective Approach. ( 30789519 )
2019
3
Adolescent Vulvar Angiokeratoma Associated with Lichen Sclerosus. ( 30974213 )
2019
4
A subungual angiokeratoma with characteristic clinical and dermoscopic features. ( 29376508 )
2018
5
Dermoscopy of Angiokeratoma. ( 29644211 )
2018
6
Angiokeratoma corporis diffusum with normal enzyme activity: three new Italian cases. ( 29786951 )
2018
7
Angiokeratoma corporis diffusum mit normaler Enzymaktivität: drei neue Fälle aus Italien. ( 29873921 )
2018
8
Solitary angiokeratoma of the vulva mimicking malignant melanoma. ( 29894537 )
2018
9
Genital angiokeratoma in a woman with Fabry disease: the dermatologist's role. ( 29924222 )
2018
10
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. ( 30156622 )
2018
11
Acral pseudolymphomatous angiokeratoma of children (APACHE): Dermoscopic features and successful treatment with CO2 laser. ( 30192034 )
2018
12
Subungual Solitary Angiokeratoma Simulating a Squamous Cell Carcinoma. ( 30197892 )
2018
13
Solitary angiokeratoma of tongue: A case report and review of the literature. ( 30589018 )
2018
14
Penile Angiokeratoma (Peaker): A Distinctive Subtype of Genital Angiokeratoma. ( 30868007 )
2018
15
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2017
16
Angiokeratoma of the gluteal region in old age. ( 27694066 )
2017
17
Angiokeratoma of Tongue. ( 28060116 )
2017
18
Solitary angiokeratoma with Meyerson phenomenon. ( 28087017 )
2017
19
Acral pseudolymphomatous angiokeratoma of children with rainbow pattern: A mimicker of Kaposi sarcoma. ( 28087020 )
2017
20
Solitary angiokeratoma presenting as cutaneous horn. ( 28406536 )
2017
21
Rare Giant Angiokeratoma of the Vulva: A Case Report. ( 28418344 )
2017
22
Unilateral angiokeratoma of the scrotum (Fordyce's type) associated with a contralateral varicocele. ( 28540880 )
2017
23
Acral angiokeratoma-like pseudolymphoma in a middle-aged woman. ( 28675468 )
2017
24
Angiokeratoma of the Glans Penis. ( 29139361 )
2017
25
Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study. ( 26371766 )
2016
26
Thrombotic phenomena in angiokeratoma can evolve into spontaneous involution of the lesions: a report of two cases. ( 26395775 )
2016
27
Angiokeratoma of Fordyce response to long pulsed Nd:YAG laser treatment. ( 26531316 )
2016
28
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
29
Radiation-induced Vulvar Angiokeratoma Along with Other Late Radiation Toxicities after Carcinoma Cervix: A Rare Case Report. ( 27057045 )
2016
30
Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance. ( 27057048 )
2016
31
Acral pseudolymphomatous angiokeratoma of children (APACHE)-like eruption in adult identical twins. ( 27663149 )
2016
32
In vivo characterization of solitary angiokeratoma by reflectance confocal microscopy and high definition optical coherence tomography. ( 25500039 )
2015
33
Efficacy of 595nm pulsed dye laser therapy for Mibelli angiokeratoma. ( 25549813 )
2015
34
Familial angiokeratoma corporis diffusum without identified enzyme defect. ( 25566897 )
2015
35
A rare case of angiokeratoma in a 8-month-old boy. ( 25678595 )
2015
36
Angiokeratoma corporis diffusum. ( 25691205 )
2015
37
Subungual angiokeratoma presenting as a longitudinal pigmented band in the nail. ( 25721145 )
2015
38
Pigmented Spitz nevus simulating a solitary angiokeratoma. ( 25773434 )
2015
39
Multicentric study on the diagnosis of Fabry's disease using angiokeratoma biopsy registries. ( 25778427 )
2015
40
An Extreme Case of Fordyce Angiokeratoma. ( 26099899 )
2015
41
Solitary Angiokeratoma: Report of Two Uncommon Cases. ( 26155544 )
2015
42
Unilateral angiokeratoma of vulva: a rare clinic entity. ( 26259393 )
2015
43
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. ( 26312700 )
2015
44
Linear acral pseudolymphomatous angiokeratoma of children with associated nail dystrophy. ( 26436972 )
2015
45
A case of solitary angiokeratoma successfully treated with a 1064-nm long-pulsed Nd:YAG laser. ( 25260142 )
2015
46
Expression of WT-1 by the vascular component of acral pseudolymphomatous angiokeratoma of children. ( 25376760 )
2015
47
Angiokeratoma of vulva mimicking genital warts. ( 25404845 )
2014
48
Angiokeratoma of the nasal vestibule: a case report. ( 25547753 )
2014
49
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
50
Angiokeratoma circumscriptum in a young male. ( 24470669 )
2014

Variations for Angiokeratoma

Expression for Angiokeratoma

Search GEO for disease gene expression data for Angiokeratoma.

Pathways for Angiokeratoma

Pathways related to Angiokeratoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 AGA CTSA FUCA1 GLA MANBA
2 11.19 AGA CTSA FUCA1 GLA MANBA NAGA
3
Show member pathways
10.72 GLA NAGA
4 10.39 AGA FUCA1 MANBA

GO Terms for Angiokeratoma

Cellular components related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 CTSA FUCA1 GLA NAGA
2 lysosomal lumen GO:0043202 9.46 CTSA FUCA1 GLA MANBA
3 azurophil granule lumen GO:0035578 9.26 AGA CTSA FUCA1 GLA
4 lysosome GO:0005764 9.1 AGA CTSA FUCA1 GLA MANBA NAGA

Biological processes related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.62 FUCA1 GLA MANBA NAGA
2 metabolic process GO:0008152 9.46 FUCA1 GLA MANBA NAGA
3 glycosphingolipid metabolic process GO:0006687 9.43 CTSA GLA
4 oligosaccharide metabolic process GO:0009311 9.4 GLA NAGA
5 glycosylceramide catabolic process GO:0046477 9.37 GLA NAGA
6 neutrophil degranulation GO:0043312 9.35 AGA CTSA FUCA1 GLA MANBA
7 glycolipid catabolic process GO:0019377 9.26 FUCA1 NAGA
8 glycoside catabolic process GO:0016139 8.8 FUCA1 GLA NAGA

Molecular functions related to Angiokeratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.43 AGA CTSA FUCA1 GLA MANBA NAGA
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.26 GLA NAGA
3 alpha-galactosidase activity GO:0004557 9.16 GLA NAGA
4 hydrolase activity, acting on glycosyl bonds GO:0016798 8.92 FUCA1 GLA MANBA NAGA

Sources for Angiokeratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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