Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: ANG007
MIFTS: 33

Angiokeratoma Circumscriptum

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
Sources

Aliases & Classifications for Angiokeratoma Circumscriptum

About this section

MalaCards integrated aliases for Angiokeratoma Circumscriptum:

Name: Angiokeratoma Circumscriptum 12 15 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5949
NCIt 50 C7751
SNOMED-CT 67 21848000
UMLS 71 C0263638
Sources

Summaries for Angiokeratoma Circumscriptum

About this section
MalaCards based summary : Angiokeratoma Circumscriptum is related to angiokeratoma and lymphangioma. An important gene associated with Angiokeratoma Circumscriptum is GLA (Galactosidase Alpha), and among its related pathways/superpathways are PAK Pathway and PI3K-Akt signaling pathway. Affiliated tissues include tongue and skin, and related phenotypes are homeostasis/metabolism and cardiovascular system

Sources

Related Diseases for Angiokeratoma Circumscriptum

About this section

Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 angiokeratoma 31.9 SLC2A1 GLA
2 lymphangioma 29.9 VEGFA PECAM1 KDR CD34
3 angiokeratoma of mibelli 29.8 NKRF MMP9 KDR GLA FLT1
4 arteriovenous malformation 29.7 VEGFA TEK MMP9 ANGPT1
5 vascular cancer 29.7 VEGFA PECAM1 KDR FLT1 CD34
6 angiokeratoma of fordyce 29.1 WT1 PECAM1 NKRF MMP9 GLA FLT1
7 hemangioma 28.8 VEGFA TEK SLC2A1 PECAM1 MMP9 KDR
8 keratosis 10.5
9 verrucous hemangioma 10.4
10 septate uterus 10.3 KDR FLT1
11 malignant ciliary body melanoma 10.3 KDR FLT1
12 fabry disease 10.3
13 skin hemangioma 10.3 SLC2A1 GLA
14 gallbladder melanoma 10.3 SLC2A1 PECAM1
15 middle ear squamous cell carcinoma 10.3 MMP9 CD34
16 pacinian tumor 10.2 SLC2A1 CD34
17 pulmonary vein stenosis 10.2 PECAM1 KDR
18 rare lymphatic malformation 10.2
19 nasal cavity benign neoplasm 10.2 MMP9 CD34
20 microcystic meningioma 10.2 VEGFA FLT1
21 bone squamous cell carcinoma 10.2 MMP9 KDR
22 skin epithelioid hemangioma 10.2 PECAM1 CD34
23 aortic malignant tumor 10.2 PECAM1 CD34
24 central nervous system angiosarcoma 10.2 PECAM1 CD34
25 intravascular angioleiomyoma 10.2 PECAM1 CD34
26 heart fibrosarcoma 10.2 PECAM1 CD34
27 ovarian angiosarcoma 10.2 PECAM1 CD34
28 conventional angiosarcoma 10.2 PECAM1 CD34
29 odontogenic myxoma 10.2 VEGFA MMP9
30 gallbladder leiomyosarcoma 10.2 PECAM1 CD34
31 thyroid sarcoma 10.2 PECAM1 CD34
32 angiomyoma 10.2 PECAM1 CD34
33 glomangiosarcoma 10.2 PECAM1 CD34
34 breast hemangioma 10.2 PECAM1 CD34
35 hemangioma of spleen 10.2 PECAM1 CD34
36 liposarcoma of bone 10.2 PECAM1 CD34
37 colonic lymphangioma 10.2 PECAM1 CD34
38 liver leiomyoma 10.2 PECAM1 CD34
39 erythema elevatum diutinum 10.2 PECAM1 CD34
40 sick building syndrome 10.2 VEGFA MMP9
41 cancer-associated retinopathy 10.2 VEGFA FLT1
42 sarcomatoid squamous cell skin carcinoma 10.2 PECAM1 CD34
43 heart sarcoma 10.2 PECAM1 CD34
44 skin sarcoma 10.2 PECAM1 CD34
45 hypertensive encephalopathy 10.2 VEGFA FLT1
46 pulmonary artery leiomyosarcoma 10.2 PECAM1 CD34
47 subungual glomus tumor 10.1 PECAM1 CD34
48 vulvar leiomyoma 10.1 PECAM1 CD34
49 thyroid angiosarcoma 10.1 PECAM1 CD34
50 angiolipoma 10.1 PECAM1 CD34

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:



Diseases related to Angiokeratoma Circumscriptum
Sources

Symptoms & Phenotypes for Angiokeratoma Circumscriptum

About this section

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 ANGPT1 CD34 FLT1 GLA KDR MMP9
2 cardiovascular system MP:0005385 10.19 ANGPT1 FLT1 GLA KDR MMP9 PECAM1
3 growth/size/body region MP:0005378 10.19 ANGPT1 FLT1 GLA KDR MMP9 NTRK1
4 cellular MP:0005384 10.18 CD34 FLT1 GLA KDR MMP9 PECAM1
5 hematopoietic system MP:0005397 10.13 CD34 FLT1 KDR MMP9 NTRK1 PECAM1
6 immune system MP:0005387 10.13 ANGPT1 CD34 FLT1 GLA KDR MMP9
7 mortality/aging MP:0010768 10.1 ANGPT1 FLT1 GLA KDR MMP9 NTRK1
8 muscle MP:0005369 10.07 ANGPT1 FLT1 GLA KDR MMP9 NTRK1
9 embryo MP:0005380 10.05 ANGPT1 FLT1 KDR SLC2A1 TEK VEGFA
10 nervous system MP:0003631 9.97 ANGPT1 FLT1 GLA KDR MMP9 NTRK1
11 no phenotypic analysis MP:0003012 9.73 KDR NKRF NTRK1 SLC2A1 VEGFA WT1
12 normal MP:0002873 9.7 FLT1 KDR NKRF NTRK1 TEK VEGFA
13 renal/urinary system MP:0005367 9.43 ANGPT1 GLA MMP9 PECAM1 VEGFA WT1
14 vision/eye MP:0005391 9.23 ANGPT1 FLT1 GLA KDR MMP9 NTRK1
Sources

Drugs & Therapeutics for Angiokeratoma Circumscriptum

About this section

Search Clinical Trials , NIH Clinical Center for Angiokeratoma Circumscriptum

Sources

Genetic Tests for Angiokeratoma Circumscriptum

About this section
Sources

Anatomical Context for Angiokeratoma Circumscriptum

About this section

MalaCards organs/tissues related to Angiokeratoma Circumscriptum:

40
Tongue, Skin
Sources

Publications for Angiokeratoma Circumscriptum

About this section

Articles related to Angiokeratoma Circumscriptum:

(show top 50) (show all 66)
# Title Authors PMID Year
1
Angiokeratoma circumscriptum. 61
33342183 2020
2
Angiokeratoma Circumscriptum on the Breast: A Case with Unusual Features. 61
32832469 2020
3
Klippel-Trenaunay Syndrome with Arterio-veno-lymphatic Malformation: A Rare Presentation. 61
32695703 2020
4
D-2-Hydroxyglutaric Aciduria with Enchondromatosis and Angiokeratoma Circumscriptum. 61
31890366 2019
5
A case report of adult-onset multiple angiokeratomas with zosteriform distribution. 61
30677813 2018
6
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. 61
33293122 2018
7
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. 61
30156622 2018
8
[Angiokeratoma circumscriptum neviforme]. 61
30041823 2018
9
Recurrent, nodular lesions over the vulva: A diagnostic challenge. 61
30623184 2018
10
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. 61
27511129 2017
11
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. 61
26736060 2016
12
Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology. 61
27631010 2016
13
Capillary malformations: a classification using specific names for specific skin disorders. 61
25864701 2015
14
Angiokeratomas Scroti Associated with Angiokeratomas of the Eyelids: Coincidence or One Entity? A Case Report and Review of the Literature. 61
26228617 2015
15
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? 61
25593797 2014
16
Angiokeratoma circumscriptum neviforme: An entity, few and far between. 61
25396132 2014
17
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. 61
25368837 2014
18
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. 61
25165655 2014
19
Angiokeratoma circumscriptum: dilemma in diagnosis. 61
24943793 2014
20
Angiokeratoma circumscriptum in a young male. 61
24470669 2014
21
[A new location of angiokeratoma circumscriptum]. 61
23199770 2012
22
Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. 61
23288806 2012
23
Dermoscopy: a useful tool for the diagnosis of angiokeratoma. 61
23197916 2012
24
Angiokeratoma circumscriptum of the tongue. 61
22565076 2012
25
Angiokeratoma circumscriptum neviforme. 61
22318117 2012
26
A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. 61
22279389 2011
27
Angiokeratoma circumscriptum of the tongue. 61
21463157 2011
28
Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. 61
21971276 2011
29
A case of post-injury angiokeratoma circumscriptum of the chest. 61
20548886 2010
30
What is a capillary malformation? 61
19022106 2008
31
[A histopathologic and imaging study of verrucous hemangioma]. 61
19087812 2008
32
A case of solitary angiokeratoma circumscriptum of the tongue. 61
18187999 2007
33
[Intergluteal angiokeratoma circumscriptum. Report of one case]. 61
17224109 2006
34
Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. 61
16848823 2006
35
Verrucous hemangioma revisited. 61
16780464 2006
36
Angiokeratoma circumscriptum of the penis. 61
16536830 2006
37
Angiokeratoma circumscriptum: a case report and review of the literature. 61
16409270 2005
38
Angiokeratoma circumscriptum of the tongue. 61
16207201 2005
39
Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. 61
15762221 2005
40
Angiokeratoma circumscriptum. 61
15458538 2004
41
Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. 61
15347502 2004
42
Angiokeratoma circumscriptum of the tongue. 61
12657024 2003
43
Successful surgical treatment of verrucous hemangioma: a combined approach. 61
12410675 2002
44
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. 61
11903167 2001
45
[Angiokeratoma circumscriptum]. 61
9921083 1998
46
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. 61
9675347 1998
47
Verrucous haemangioma--a case report. 61
9663320 1998
48
[Multiple Fordyce-type angiokeratomas of the scrotum. An iatrogenic case]. 61
9628980 1998
49
Angiokeratomas: an update. 61
8993949 1996
50
Argon laser treatment of cutaneous multiple angiokeratomas. 61
7894939 1995
Sources

Variations for Angiokeratoma Circumscriptum

About this section
Sources

Expression for Angiokeratoma Circumscriptum

About this section
Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.
Sources

Pathways for Angiokeratoma Circumscriptum

About this section

Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 63
Show member pathways
 13.11 TEK SLC2A1 NTRK1 KDR FLT1 ANGPT1
2
PI3K-Akt signaling pathway 36
Show member pathways
 12.77 VEGFA TEK NTRK1 KDR FLT1 ANGPT1
3
MAPK signaling pathway 36 1
12.51 VEGFA TEK NTRK1 KDR FLT1 ANGPT1
4
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 64
Show member pathways
 12.48 VEGFA PECAM1 MMP9 KDR
5
Ras signaling pathway 36
Show member pathways
 12.44 VEGFA TEK NTRK1 KDR FLT1 ANGPT1
6
Calcium signaling pathway 36
12.23 VEGFA NTRK1 KDR FLT1
7
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.21 TEK NTRK1 KDR FLT1
8
Transcriptional misregulation in cancer 36
12.12 WT1 NTRK1 MMP9 FLT1
9
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.07 TEK NTRK1 KDR FLT1
10
Tyrosine Kinases / Adaptors 4
11.97 TEK NTRK1 KDR FLT1
11
Fluid shear stress and atherosclerosis 36
11.92 VEGFA PECAM1 MMP9 KDR
12
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.9 WT1 VEGFA KDR
13
S1P3 pathway 1
Show member pathways
 11.83 VEGFA KDR FLT1
14
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.72 VEGFA KDR FLT1
15
Rheumatoid arthritis 36
11.7 VEGFA TEK FLT1 ANGPT1
16
HIF-1 signaling pathway 36
11.59 VEGFA TEK SLC2A1 FLT1 ANGPT1
17
Vemurafenib Pathway, Pharmacodynamics 60
11.33 VEGFA KDR FLT1
18
Angiogenesis (CST) 4
11.3 TEK PECAM1 MMP9 KDR FLT1
19
Photodynamic therapy-induced HIF-1 survival signaling 1
11.25 VEGFA SLC2A1 ANGPT1
20
HIF-2-alpha transcription factor network 1
11.09 VEGFA SLC2A1 KDR FLT1
21
Glypican 1 network 1
11.03 VEGFA FLT1
22
G-protein signaling_Rap2B regulation pathway 23
10.86 TEK NTRK1 KDR FLT1 ANGPT1
23
VEGF binds to VEGFR leading to receptor dimerization 65
Show member pathways
 10.78 VEGFA KDR FLT1
24
Angiogenesis (WikiPathways) 1
10.48 VEGFA TEK MMP9 KDR FLT1 ANGPT1
Sources

GO Terms for Angiokeratoma Circumscriptum

About this section

Cellular components related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 VEGFA TEK MMP9 KDR GLA FLT1
2 integral component of plasma membrane GO:0005887 9.5 TEK SLC2A1 PECAM1 NTRK1 KDR FLT1
3 receptor complex GO:0043235 9.46 TEK NTRK1 KDR FLT1
4 membrane raft GO:0045121 9.02 TEK SLC2A1 PECAM1 KDR ANGPT1

Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.13 VEGFA TEK NTRK1 KDR FLT1 ANGPT1
2 positive regulation of cell migration GO:0030335 9.93 VEGFA PECAM1 MMP9 KDR FLT1
3 angiogenesis GO:0001525 9.92 VEGFA TEK KDR FLT1 ANGPT1
4 protein autophosphorylation GO:0046777 9.9 TEK NTRK1 KDR FLT1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 VEGFA TEK NTRK1 KDR ANGPT1
6 peptidyl-tyrosine phosphorylation GO:0018108 9.86 TEK NTRK1 KDR FLT1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 VEGFA PECAM1 ANGPT1
8 leukocyte migration GO:0050900 9.83 TEK PECAM1 MMP9 CD34 ANGPT1
9 positive regulation of endothelial cell proliferation GO:0001938 9.82 VEGFA TEK KDR
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.82 VEGFA KDR FLT1
11 vasculogenesis GO:0001570 9.81 WT1 VEGFA KDR
12 positive regulation of angiogenesis GO:0045766 9.8 VEGFA TEK KDR FLT1 CD34
13 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 VEGFA KDR ANGPT1
14 positive regulation of kinase activity GO:0033674 9.78 TEK NTRK1 KDR FLT1
15 negative regulation of endothelial cell apoptotic process GO:2000352 9.76 TEK KDR ANGPT1
16 positive regulation of endothelial cell migration GO:0010595 9.76 VEGFA TEK KDR ANGPT1
17 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.75 VEGFA KDR FLT1
18 sprouting angiogenesis GO:0002040 9.74 VEGFA TEK ANGPT1
19 positive regulation of focal adhesion assembly GO:0051894 9.72 VEGFA TEK KDR
20 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.72 TEK NTRK1 KDR FLT1 ANGPT1
21 negative regulation of apoptotic process GO:0043066 9.7 WT1 VEGFA TEK NTRK1 MMP9 KDR
22 vascular endothelial growth factor signaling pathway GO:0038084 9.69 VEGFA KDR FLT1
23 positive regulation of receptor internalization GO:0002092 9.68 VEGFA ANGPT1
24 macrophage differentiation GO:0030225 9.68 VEGFA MMP9
25 negative regulation of nitric oxide biosynthetic process GO:0045019 9.67 GLA CD34
26 cell migration involved in sprouting angiogenesis GO:0002042 9.67 VEGFA KDR
27 endothelial cell proliferation GO:0001935 9.67 TEK CD34
28 positive regulation of vasculogenesis GO:2001214 9.66 KDR CD34
29 positive regulation of positive chemotaxis GO:0050927 9.66 VEGFA KDR
30 positive regulation of MAPK cascade GO:0043410 9.65 VEGFA TEK NTRK1 KDR FLT1
31 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.63 VEGFA KDR
32 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.63 VEGFA KDR
33 endothelium development GO:0003158 9.62 KDR CD34
34 glomerulus vasculature development GO:0072012 9.61 TEK ANGPT1
35 Tie signaling pathway GO:0048014 9.61 TEK ANGPT1
36 glomerular endothelium development GO:0072011 9.59 PECAM1 CD34
37 vascular wound healing GO:0061042 9.54 VEGFA KDR CD34
38 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 VEGFA TEK NTRK1 KDR FLT1 ANGPT1
39 positive regulation of protein phosphorylation GO:0001934 9.17 VEGFA TEK PECAM1 NTRK1 MMP9 KDR

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 VEGFA TEK SLC2A1 NTRK1 MMP9 KDR
2 growth factor binding GO:0019838 9.33 TEK KDR FLT1
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 KDR FLT1
4 protein tyrosine kinase activity GO:0004713 9.26 TEK NTRK1 KDR FLT1
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 TEK NTRK1 KDR FLT1
Sources

Sources for Angiokeratoma Circumscriptum

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....