Angiokeratoma Circumscriptum disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Angiokeratoma Circumscriptum

MalaCards integrated aliases for Angiokeratoma Circumscriptum:

IMPROVED

Name: Angiokeratoma Circumscriptum ¹¹ ¹⁴ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5949

NCIt ⁴⁹ C7751

SNOMED-CT ⁶⁸ 21848000

UMLS ⁷¹ C0263638

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Summaries for Angiokeratoma Circumscriptum

MalaCards based summary: Angiokeratoma Circumscriptum is related to angiokeratoma and capillary lymphangioma. An important gene associated with Angiokeratoma Circumscriptum is SYNGAP1 (Synaptic Ras GTPase Activating Protein 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. Affiliated tissues include skin, tongue and breast, and related phenotypes are nervous system and homeostasis/metabolism

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Related Diseases for Angiokeratoma Circumscriptum

Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)

#	Related Disease	Score	Top Affiliating Genes
1	angiokeratoma	31.2	WT1 SLC2A1 GLA
2	capillary lymphangioma	30.1	SYNGAP1 RASA1 PECAM1 CD34 AGGF1
3	lymphangioma	29.9	VEGFA PECAM1 KDR CD34
4	angiokeratoma of mibelli	29.8	MMP9 KDR GLA FLT1
5	klippel-trenaunay-weber syndrome	29.6	VEGFA TEK SYNGAP1 RASA1 PECAM1 AGGF1
6	angiokeratoma of fordyce	29.4	WT1 PECAM1 MMP9 GLA FLT1
7	hemangioma	28.6	VEGFA TEK SLC2A1 PECAM1 MMP9 KDR
8	arteriovenous malformation	28.6	VEGFA TEK SYNGAP1 SLC2A1 RASA1 PECAM1
9	capillary hemangioma	28.3	VEGFA TEK SYNGAP1 SLC2A1 RASA1 PECAM1
10	fabry disease	10.4
11	verrucous hemangioma	10.4
12	hemangioma of intra-abdominal structure	10.3	SYNGAP1 RASA1
13	taylor's syndrome	10.3	SYNGAP1 RASA1
14	lymphatic malformation 12	10.3	SYNGAP1 RASA1
15	epilepsy with myoclonic-atonic seizures	10.3	SYNGAP1 SLC2A1
16	perivascular tumor	10.2	PECAM1 CD34
17	angiolipoma	10.2	PECAM1 CD34
18	skin epithelioid hemangioma	10.2	PECAM1 CD34
19	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.2
20	muscle hypertrophy	10.2
21	melanoma	10.2
22	papilloma	10.2
23	rare lymphatic malformation	10.2
24	pacinian tumor	10.2	SLC2A1 CD34
25	aorta angiosarcoma	10.2	PECAM1 CD34
26	central nervous system angiosarcoma	10.2	PECAM1 CD34
27	intravascular angioleiomyoma	10.2	PECAM1 CD34
28	angiomatous meningioma	10.2	CD34 AGGF1
29	metatypical basal cell carcinoma	10.2	CD34 AGGF1
30	rapidly involuting congenital hemangioma	10.2	SLC2A1 PECAM1
31	heart fibrosarcoma	10.2	PECAM1 CD34
32	thyroid angiosarcoma	10.2	PECAM1 CD34
33	glomangiomatosis	10.2	PECAM1 CD34
34	gallbladder leiomyosarcoma	10.2	PECAM1 CD34
35	venous hemangioma	10.2	PECAM1 CD34
36	intracranial structure hemangioma	10.2	SYNGAP1 RASA1
37	ovarian angiosarcoma	10.2	PECAM1 CD34
38	conventional angiosarcoma	10.2	PECAM1 CD34
39	kidney hemangiopericytoma	10.2	PECAM1 CD34
40	intracranial cavernous angioma	10.2	SYNGAP1 RASA1
41	glomangiomyoma	10.2	PECAM1 CD34
42	angiomyoma	10.2	PECAM1 CD34
43	glomangiosarcoma	10.2	PECAM1 CD34
44	breast hemangioma	10.2	PECAM1 CD34
45	thyroid sarcoma	10.2	PECAM1 CD34
46	liposarcoma of bone	10.2	PECAM1 CD34
47	hemangioma of spleen	10.2	PECAM1 CD34
48	meninges hemangiopericytoma	10.2	PECAM1 CD34
49	colonic lymphangioma	10.2	PECAM1 CD34
50	epithelioid hemangioendothelioma	10.2	PECAM1 CD34

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:

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Symptoms & Phenotypes for Angiokeratoma Circumscriptum

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.22	AGGF1 ANGPT1 FLT1 GLA KDR MMP9
2	homeostasis/metabolism	MP:0005376	10.17	ANGPT1 CD34 FLT1 GLA KDR MMP9
3	muscle	MP:0005369	10.16	ANGPT1 FLT1 GLA KDR MMP9 PECAM1
4	growth/size/body region	MP:0005378	10.14	ANGPT1 FLT1 GLA KDR MMP9 RASA1
5	cellular	MP:0005384	10.1	AGGF1 CD34 FLT1 GLA KDR MMP9
6	embryo	MP:0005380	10.02	AGGF1 ANGPT1 FLT1 KDR RASA1 SLC2A1
7	cardiovascular system	MP:0005385	10	AGGF1 ANGPT1 FLT1 GLA KDR MMP9
8	immune system	MP:0005387	9.85	ANGPT1 CD34 FLT1 GLA KDR MMP9
9	vision/eye	MP:0005391	9.56	ANGPT1 FLT1 GLA KDR MMP9 RASA1
10	mortality/aging	MP:0010768	9.4	AGGF1 ANGPT1 FLT1 GLA KDR MMP9

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Drugs & Therapeutics for Angiokeratoma Circumscriptum

Search Clinical Trials, NIH Clinical Center for Angiokeratoma Circumscriptum

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Genetic Tests for Angiokeratoma Circumscriptum

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Anatomical Context for Angiokeratoma Circumscriptum

Organs/tissues related to Angiokeratoma Circumscriptum:

MalaCards : Skin, Tongue, Breast

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Publications for Angiokeratoma Circumscriptum

Articles related to Angiokeratoma Circumscriptum:

(show top 50) (show all 69)

#	Title	Authors	PMID	Year
1	Angiokeratoma Circumscriptum Naeviforme on Trunk. ⁶²	Chhabra G...Verma P	33980054	2022
2	Linear lesions in dermatology: a clinicoaetiopathological study. ⁶²	Das A...Bandyopadhyay D	34022084	2021
3	Angiokeratoma Circumscriptum Naeviforme Presenting as a Dark Warty Plaque on the Leg. ⁶²	Abbenante D...Patrizi A	34990348	2021
4	Angiokeratoma circumscriptum. ⁶²	Guillen-Climent S...Pinazo I	33342183	2020
5	Angiokeratoma Circumscriptum on the Breast: A Case with Unusual Features. ⁶²	Bansal A...Gupta T	32832469	2020
6	Klippel-Trenaunay Syndrome with Arterio-veno-lymphatic Malformation: A Rare Presentation. ⁶²	Supekar BB...Suresh P	32695703	2020
7	D-2-Hydroxyglutaric Aciduria with Enchondromatosis and Angiokeratoma Circumscriptum. ⁶²	Preston A...Hirshburg JM	31890366	2019
8	A case report of adult-onset multiple angiokeratomas with zosteriform distribution. ⁶²	Grewal AK...Silverstein M	30677813	2018
9	Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. ⁶²	Oppermann K...Bonamigo RR	30156622	2018
10	[Angiokeratoma circumscriptum neviforme]. ⁶²	Kassem Youssef H...Michel C	30041823	2018
11	Recurrent, nodular lesions over the vulva: A diagnostic challenge. ⁶²	Samudrala S...Bhat MR	30623184	2018
12	Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ⁶²	Lorgeou A...Passeron T	27511129	2017
13	Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ⁶²	Baumgartner J...Babal P	26736060	2016
14	Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology. ⁶²	Nistico S...Cannarozzo G	27631010	2016
15	Capillary malformations: a classification using specific names for specific skin disorders. ⁶²	Happle R	25864701	2015
16	Angiokeratomas Scroti Associated with Angiokeratomas of the Eyelids: Coincidence or One Entity? A Case Report and Review of the Literature. ⁶²	Buehler S...Itin P	26228617	2015
17	Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ⁶²	Wankhade V...Disawal A	25593797	2014
18	Angiokeratoma circumscriptum neviforme: An entity, few and far between. ⁶²	Das A...Gharami RC	25396132	2014
19	Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ⁶²	Kang YH...Park BW	25368837	2014
20	Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ⁶²	Jindal SR...Jerajani HR	25165655	2014
21	Angiokeratoma circumscriptum: dilemma in diagnosis. ⁶²	Agrawal SN...Jane SD	24943793	2014
22	Angiokeratoma circumscriptum in a young male. ⁶²	Sadana D...Dogra BB	24470669	2014
23	Dermoscopy: a useful tool for the diagnosis of angiokeratoma. ⁶²	Kim JH...Lee SH	23197916	2012
24	[A new location of angiokeratoma circumscriptum]. ⁶²	Bouaddi M...Gelmetti CM	23199770	2012
25	Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. ⁶²	Madana J...Saxena SK	23288806	2012
26	Angiokeratoma circumscriptum of the tongue. ⁶²	Aggarwal K...Wadhera R	22565076	2012
27	Angiokeratoma circumscriptum neviforme. ⁶²	Debbarman P...Kumar P	22318117	2012
28	Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. ⁶²	Ghosh SK...Haldar S	21971276	2011
29	A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. ⁶²	Kar HK...Gupta L	22279389	2011
30	Angiokeratoma circumscriptum of the tongue. ⁶²	Eskiizmir G...Ermertcan AT	21463157	2011
31	A case of post-injury angiokeratoma circumscriptum of the chest. ⁶²	Kwon NH...Kim GM	20548886	2010
32	What is a capillary malformation? ⁶²	Happle R	19022106	2008
33	[A histopathologic and imaging study of verrucous hemangioma]. ⁶²	Garrido-Rios AA...Miranda-Romero A	19087812	2008
34	A case of solitary angiokeratoma circumscriptum of the tongue. ⁶²	Yildirim M...Topcu I	18187999	2007
35	[Intergluteal angiokeratoma circumscriptum. Report of one case]. ⁶²	Sierra-Luzuriaga G...Leone-Stay G	17224109	2006
36	Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. ⁶²	Bechara FG...Jansen T	16848823	2006
37	Verrucous hemangioma revisited. ⁶²	Tennant LB...Kozakewich HP	16780464	2006
38	Angiokeratoma circumscriptum of the penis. ⁶²	Saha M...Bunker CB	16536830	2006
39	Angiokeratoma circumscriptum: a case report and review of the literature. ⁶²	Mittal R...Srivastava G	16409270	2005
40	Angiokeratoma circumscriptum of the tongue. ⁶²	Varshney S	16207201	2005
41	Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. ⁶²	del Pozo J...Fonseca E	15762221	2005
42	Angiokeratoma circumscriptum. ⁶²	Ozdemir R...Kocer U	15458538	2004
43	Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. ⁶²	Sodaifi M...Monabati A	15347502	2004
44	Angiokeratoma circumscriptum of the tongue. ⁶²	Vijaikumar M...Jayanthi S	12657024	2003
45	Successful surgical treatment of verrucous hemangioma: a combined approach. ⁶²	Yang CH...Ohara K	12410675	2002
46	Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. ⁶²	Sardana K...Mahajan S	11903167	2001
47	Angiokeratoma circumscriptum of the oral cavity. ⁶²	Kumar MV...Ratnakar C	9833054	1998
48	[Angiokeratoma circumscriptum]. ⁶²	Nikolic B...Mladenovic T	9921083	1998
49	A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. ⁶²	Kobayashi T...Sakuraoka K	9675347	1998
50	Verrucous haemangioma--a case report. ⁶²	Tan YY...Tan PH	9663320	1998

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Genes for Angiokeratoma Circumscriptum

Genes related to Angiokeratoma Circumscriptum (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	5.12	DISEASES inferred ¹⁴
2	RASA1	RAS P21 Protein Activator 1	Protein Coding	5.08	DISEASES inferred ¹⁴
3	GLA	Galactosidase Alpha	Protein Coding	4.72	DISEASES inferred ¹⁴
4	AGGF1	Angiogenic Factor With G-Patch And FHA Domains 1	Protein Coding	4.68	DISEASES inferred ¹⁴
5	MMP9	Matrix Metallopeptidase 9	Protein Coding	4.49	DISEASES inferred ¹⁴
6	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	4.25	DISEASES inferred ¹⁴
7	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	3.96	DISEASES inferred ¹⁴
8	CD34	CD34 Molecule	Protein Coding	3.95	DISEASES inferred ¹⁴
9	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	3.93	DISEASES inferred ¹⁴
10	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	3.88	DISEASES inferred ¹⁴
11	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	3.75	DISEASES inferred ¹⁴
12	KDR	Kinase Insert Domain Receptor	Protein Coding	3.62	DISEASES inferred ¹⁴
13	WT1	WT1 Transcription Factor	Protein Coding	3.48	DISEASES inferred ¹⁴
14	ANGPT1	Angiopoietin 1	Protein Coding	3.04	DISEASES inferred ¹⁴

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Variations for Angiokeratoma Circumscriptum

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Expression for Angiokeratoma Circumscriptum

Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.

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Pathways for Angiokeratoma Circumscriptum

Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 39)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.68	VEGFA TEK SYNGAP1 RASA1 KDR FLT1
2	Signal Transduction ⁶⁶	13.64	VEGFA TEK SYNGAP1 RASA1 MMP9 KDR
3	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.24	AGGF1 ANGPT1 KDR RASA1 SYNGAP1 TEK
4	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.81	VEGFA TEK SLC2A1 KDR FLT1 ANGPT1
5	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.72	VEGFA RASA1 MMP9 KDR FLT1
6	Malignant pleural mesothelioma ⁷⁴	12.31	VEGFA TEK SLC2A1 MMP9 KDR FLT1
7	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.26	TEK RASA1 KDR FLT1
8	Signaling by VEGF ⁶⁶ Show member pathways VEGFA-VEGFR2 Pathway ⁶⁶	12.21	VEGFA RASA1 KDR FLT1
9	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.09	TEK PECAM1 ANGPT1
10	VEGF Signaling Pathway ⁶⁰ ⁶⁷ Show member pathways Nanoparticle-mediated activation of receptor signaling ⁷⁴ TGF-beta Signaling ⁶⁷	12.09	VEGFA KDR FLT1
11	Ras signaling ⁷⁴	12.09	FLT1 KDR RASA1 SYNGAP1 TEK
12	Tyrosine Kinases / Adaptors ³	12.01	TEK KDR FLT1
13	CCR3 Pathway in Eosinophils ⁶⁴ Show member pathways VEGF and S-1P Signaling ⁶⁴	12	VEGFA RASA1 KDR
14	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.95	WT1 VEGFA KDR
15	Hippo-Merlin signaling dysregulation ⁷⁴ Show member pathways Hippo signaling regulation pathways ⁷⁴	11.77	TEK KDR FLT1
16	Clear cell renal cell carcinoma pathways ⁷⁴	11.71	VEGFA SLC2A1 KDR FLT1
17	Burn wound healing ⁷⁴	11.67	VEGFA PECAM1 MMP9
18	Angiogenesis (CST) ³	11.6	TEK PECAM1 MMP9 KDR FLT1
19	Signaling events mediated by VEGFR1 and VEGFR2 ⁶¹	11.59	VEGFA KDR FLT1
20	SHP2 signaling ⁶¹	11.44	VEGFA TEK KDR ANGPT1
21	Genes controlling nephrogenesis ⁷⁴	11.4	KDR VEGFA WT1
22	"Vemurafenib Pathway, Pharmacodynamics" ⁶⁰	11.39	VEGFA KDR FLT1
23	Beta3 integrin cell surface interactions ⁶¹	11.32	VEGFA PECAM1 KDR
24	G-protein signaling_H-RAS regulation pathway ²²	11.31	TEK RASA1 ANGPT1
25	Photodynamic therapy-induced HIF-1 survival signaling ⁷⁴	11.29	VEGFA SLC2A1 ANGPT1
26	Neovascularisation processes ⁷⁴	11.24	MMP9 KDR ANGPT1
27	HIF-2-alpha transcription factor network ⁶¹	11.1	VEGFA SLC2A1 KDR FLT1
28	VEGFR1 specific signals ⁶¹	11.08	VEGFA RASA1 FLT1
29	Extracellular vesicles in the crosstalk of cardiac cells ⁷⁴	11.01	MMP9 KDR
30	VEGFR2 mediated cell proliferation ⁶⁶	10.99	VEGFA RASA1 KDR
31	Glypican 1 network ⁶¹	10.93	VEGFA FLT1
32	VEGF ligand-receptor interactions ⁶⁶ Show member pathways VEGF binds to VEGFR leading to receptor dimerization ⁶⁶	10.84	VEGFA KDR FLT1
33	S1P3 pathway ⁶¹	10.82	VEGFA FLT1
34	S1P1 pathway ⁶¹	10.79	VEGFA KDR
35	NRP1-triggered signaling pathways in pancreatic cancer ⁷⁴	10.75	VEGFA PECAM1 MMP9 KDR FLT1
36	Angiogenesis (WikiPathways) ⁷⁴	10.54	TEK MMP9 KDR FLT1
37	"Regorafenib Pathway, Pharmacodynamics" ⁶⁰	10.45	TEK KDR FLT1
38	Robo4 and VEGF signaling pathways crosstalk ⁷⁴	10.4	VEGFA KDR
39	SARS-CoV-2 altering angiogenesis via NRP1 ⁷⁴	10.3	VEGFA KDR

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GO Terms for Angiokeratoma Circumscriptum

Cellular components related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.09	VEGFA TEK MMP9 KDR GLA FLT1
2	plasma membrane	GO:0005886	9.91	CD34 FLT1 KDR PECAM1 SLC2A1 TEK
3	plasma membrane	GO:0005887	9.91	CD34 FLT1 KDR PECAM1 SLC2A1 TEK
4	membrane raft	GO:0045121	9.28	TEK SLC2A1 PECAM1 KDR ANGPT1

Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 33)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell migration	GO:0030335	10.26	VEGFA PECAM1 KDR FLT1
2	negative regulation of apoptotic process	GO:0043066	10.25	WT1 VEGFA TEK RASA1 MMP9 KDR
3	negative regulation of neuron apoptotic process	GO:0043524	10.2	SYNGAP1 RASA1 KDR ANGPT1
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.19	ANGPT1 KDR TEK VEGFA
5	positive regulation of MAPK cascade	GO:0043410	10.17	VEGFA TEK KDR FLT1
6	angiogenesis	GO:0001525	10.15	AGGF1 ANGPT1 FLT1 KDR TEK VEGFA
7	positive regulation of kinase activity	GO:0033674	10.11	TEK KDR FLT1
8	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	10.1	TEK KDR FLT1 ANGPT1
9	positive regulation of blood vessel endothelial cell migration	GO:0043536	10.08	VEGFA KDR ANGPT1
10	positive regulation of endothelial cell proliferation	GO:0001938	10.08	VEGFA TEK KDR AGGF1
11	hemopoiesis	GO:0030097	10.04	KDR CD34 ANGPT1
12	positive regulation of endothelial cell migration	GO:0010595	10.03	VEGFA TEK KDR ANGPT1
13	positive regulation of protein phosphorylation	GO:0001934	10.03	VEGFA TEK PECAM1 MMP9 KDR ANGPT1
14	negative regulation of endothelial cell apoptotic process	GO:2000352	10.02	TEK KDR ANGPT1
15	sprouting angiogenesis	GO:0002040	10.01	VEGFA TEK ANGPT1
16	cellular response to vascular endothelial growth factor stimulus	GO:0035924	10	FLT1 KDR VEGFA
17	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.99	VEGFA KDR FLT1
18	positive regulation of focal adhesion assembly	GO:0051894	9.97	VEGFA TEK KDR
19	positive regulation of vasculogenesis	GO:2001214	9.96	KDR CD34
20	positive regulation of positive chemotaxis	GO:0050927	9.95	VEGFA KDR
21	endothelium development	GO:0003158	9.93	KDR CD34
22	vascular endothelial growth factor signaling pathway	GO:0038084	9.93	FLT1 KDR VEGFA
23	vascular endothelial growth factor receptor-2 signaling pathway	GO:0036324	9.92	KDR VEGFA
24	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	9.91	KDR VEGFA
25	Tie signaling pathway	GO:0048014	9.89	ANGPT1 TEK
26	glomerular endothelium development	GO:0072011	9.88	CD34 PECAM1
27	glomerulus vasculature development	GO:0072012	9.88	ANGPT1 TEK
28	regulation of MAPK cascade	GO:0043408	9.87	SYNGAP1 KDR FLT1
29	multicellular organism development	GO:0007275	9.81	TEK KDR FLT1
30	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.81	ANGPT1 FLT1 KDR TEK VEGFA
31	vascular wound healing	GO:0061042	9.8	VEGFA KDR CD34
32	positive regulation of angiogenesis	GO:0045766	9.73	VEGFA TEK KDR FLT1 CD34 AGGF1
33	vasculogenesis	GO:0001570	9.32	WT1 VEGFA RASA1 KDR AGGF1

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor receptor activity	GO:0005021	9.26	KDR FLT1
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.1	TEK KDR FLT1

Sources

Sources for Angiokeratoma Circumscriptum

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ANG007 MIFTS: 33	Angiokeratoma Circumscriptum Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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