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MCID: ANG007
MIFTS: 32

Angiokeratoma Circumscriptum

Categories: Cancer diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Angiokeratoma Circumscriptum

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MalaCards integrated aliases for Angiokeratoma Circumscriptum:

Name: Angiokeratoma Circumscriptum 12 15 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5949
NCIt 50 C7751
SNOMED-CT 68 21848000
UMLS 72 C0263638
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Summaries for Angiokeratoma Circumscriptum

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MalaCards based summary : Angiokeratoma Circumscriptum is related to lymphangioma and vascular cancer. An important gene associated with Angiokeratoma Circumscriptum is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are GPCR Pathway and Pathways in cancer. Affiliated tissues include tongue and skin, and related phenotypes are Synthetic lethal with gemcitabine and cellular

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Related Diseases for Angiokeratoma Circumscriptum

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Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 lymphangioma 30.6 VEGFA KDR
2 vascular cancer 29.7 VEGFA KDR FLT1
3 hemangioma 29.6 VEGFA SLC2A1 KDR FLT1
4 arteriovenous malformation 29.6 VEGFA RASA1 MMP9
5 angiokeratoma 11.0
6 keratosis 10.6
7 verrucous hemangioma 10.5
8 fabry disease 10.4
9 rare lymphatic malformation 10.3
10 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.3 SLC2A1 RASA1
11 renal pelvis carcinoma 10.2 VEGFA SLC2A1
12 klippel-trenaunay-weber syndrome 10.2
13 lipomatosis, multiple 10.2
14 capillary malformations, congenital 10.2
15 fucosidosis 10.2
16 nodular malignant melanoma 10.2
17 pleomorphic lipoma 10.2
18 melanoma 10.2
19 basal cell carcinoma 10.2
20 papilloma 10.2
21 pigmented basal cell carcinoma 10.2
22 angiokeratoma of mibelli 10.2
23 angiokeratoma of fordyce 10.2
24 glomeruloid hemangioma 10.2 VEGFA FLT1
25 microcystic meningioma 10.2 VEGFA FLT1
26 cancer-associated retinopathy 10.2 VEGFA FLT1
27 lipodermatosclerosis 10.2 VEGFA FLT1
28 acute mountain sickness 10.1 VEGFA FLT1
29 breast carcinoma in situ 10.1 VEGFA FLT1
30 hemangioblastoma 10.1 VEGFA SLC2A1
31 radiation proctitis 10.1 VEGFA KDR
32 placenta accreta 10.1 KDR FLT1
33 angiomatous meningioma 10.1 VEGFA KDR
34 drug-induced lupus erythematosus 10.0 VEGFA KDR
35 leukostasis 10.0 VEGFA KDR
36 coats disease 10.0 VEGFA KDR
37 epileptic encephalopathy, childhood-onset 10.0 VEGFA KDR
38 degeneration of macula and posterior pole 10.0 VEGFA KDR
39 limb ischemia 10.0 VEGFA KDR
40 cerebrum cancer 10.0 VEGFA KDR
41 supratentorial cancer 10.0 VEGFA KDR
42 ovarian hyperstimulation syndrome 9.9 VEGFA KDR
43 adamantinous craniopharyngioma 9.9 VEGFA MMP9
44 sick building syndrome 9.9 VEGFA MMP9
45 ischemic colitis 9.9 VEGFA MMP9
46 odontogenic myxoma 9.9 VEGFA MMP9
47 tuberculous meningitis 9.9 VEGFA MMP9
48 rosacea 9.8 VEGFA MMP9
49 nasopharyngeal disease 9.8 VEGFA MMP9
50 pharynx cancer 9.8 VEGFA MMP9

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:



Diseases related to Angiokeratoma Circumscriptum
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Symptoms & Phenotypes for Angiokeratoma Circumscriptum

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GenomeRNAi Phenotypes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
2 cardiovascular system MP:0005385 9.83 FLT1 KDR MMP9 RASA1 VEGFA
3 growth/size/body region MP:0005378 9.8 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
4 embryo MP:0005380 9.77 FLT1 KDR RASA1 SLC2A1 VEGFA
5 mortality/aging MP:0010768 9.73 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
6 muscle MP:0005369 9.55 FLT1 KDR MMP9 RASA1 VEGFA
7 nervous system MP:0003631 9.43 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
8 no phenotypic analysis MP:0003012 8.92 KDR RASA1 SLC2A1 VEGFA
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Drugs & Therapeutics for Angiokeratoma Circumscriptum

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Search Clinical Trials , NIH Clinical Center for Angiokeratoma Circumscriptum

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Genetic Tests for Angiokeratoma Circumscriptum

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Anatomical Context for Angiokeratoma Circumscriptum

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MalaCards organs/tissues related to Angiokeratoma Circumscriptum:

41
Tongue, Skin
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Publications for Angiokeratoma Circumscriptum

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Articles related to Angiokeratoma Circumscriptum:

(show top 50) (show all 62)
# Title Authors PMID Year
1
A case report of adult-onset multiple angiokeratomas with zosteriform distribution. 38
30677813 2018
2
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. 38
30156622 2018
3
[Angiokeratoma circumscriptum neviforme]. 38
30041823 2018
4
Recurrent, nodular lesions over the vulva: A diagnostic challenge. 38
30623184 2018
5
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. 38
27511129 2017
6
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. 38
26736060 2016
7
Nonconventional Use of Flash-Lamp Pulsed-Dye Laser in Dermatology. 38
27631010 2016
8
Capillary malformations: a classification using specific names for specific skin disorders. 38
25864701 2015
9
Angiokeratomas Scroti Associated with Angiokeratomas of the Eyelids: Coincidence or One Entity? A Case Report and Review of the Literature. 38
26228617 2015
10
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? 38
25593797 2014
11
Angiokeratoma circumscriptum neviforme: An entity, few and far between. 38
25396132 2014
12
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. 38
25368837 2014
13
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. 38
25165655 2014
14
Angiokeratoma circumscriptum: dilemma in diagnosis. 38
24943793 2014
15
Angiokeratoma circumscriptum in a young male. 38
24470669 2014
16
Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. 38
23288806 2012
17
Dermoscopy: a useful tool for the diagnosis of angiokeratoma. 38
23197916 2012
18
[A new location of angiokeratoma circumscriptum]. 38
23199770 2012
19
Angiokeratoma circumscriptum of the tongue. 38
22565076 2012
20
Angiokeratoma circumscriptum neviforme. 38
22318117 2012
21
Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. 38
21971276 2011
22
Angiokeratoma circumscriptum of the tongue. 38
21463157 2011
23
A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. 38
22279389 2011
24
A case of post-injury angiokeratoma circumscriptum of the chest. 38
20548886 2010
25
What is a capillary malformation? 38
19022106 2008
26
[A histopathologic and imaging study of verrucous hemangioma]. 38
19087812 2008
27
A case of solitary angiokeratoma circumscriptum of the tongue. 38
18187999 2007
28
[Intergluteal angiokeratoma circumscriptum. Report of one case]. 38
17224109 2006
29
Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. 38
16848823 2006
30
Verrucous hemangioma revisited. 38
16780464 2006
31
Angiokeratoma circumscriptum of the penis. 38
16536830 2006
32
Angiokeratoma circumscriptum: a case report and review of the literature. 38
16409270 2005
33
Angiokeratoma circumscriptum of the tongue. 38
16207201 2005
34
Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. 38
15762221 2005
35
Angiokeratoma circumscriptum. 38
15458538 2004
36
Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. 38
15347502 2004
37
Angiokeratoma circumscriptum of the tongue. 38
12657024 2003
38
Successful surgical treatment of verrucous hemangioma: a combined approach. 38
12410675 2002
39
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. 38
11903167 2001
40
Angiokeratoma circumscriptum of the oral cavity. 38
9833054 1998
41
[Angiokeratoma circumscriptum]. 38
9921083 1998
42
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. 38
9675347 1998
43
Verrucous haemangioma--a case report. 38
9663320 1998
44
[Multiple Fordyce-type angiokeratomas of the scrotum. An iatrogenic case]. 38
9628980 1998
45
Angiokeratomas: an update. 38
8993949 1996
46
Argon laser treatment of cutaneous multiple angiokeratomas. 38
7894939 1995
47
Multinodular hemosiderotic dermatofibroma. 38
2073965 1990
48
Angiokeratoma Circumscriptum. 38
28128171 1989
49
Verrucous hemangioma and angiokeratoma circumscriptum: clinical and histologic differential characteristics. 38
2910968 1989
50
Angiokeratoma circumscriptum: successful treatment with the argon laser. 38
3281548 1988
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Variations for Angiokeratoma Circumscriptum

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Expression for Angiokeratoma Circumscriptum

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Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.
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Pathways for Angiokeratoma Circumscriptum

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Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
GPCR Pathway 64
Show member pathways
 13.38 VEGFA RASA1 MMP9 KDR FLT1
2
Pathways in cancer 37
12.58 VEGFA SLC2A1 MMP9
3
Glioma 37
Show member pathways
 12.44 VEGFA MMP9 KDR
4
MAPK signaling pathway 37 1
12.43 VEGFA RASA1 KDR FLT1
5
Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways 65
Show member pathways
 12.4 VEGFA MMP9 KDR
6
Ras signaling pathway 37
Show member pathways
 12.38 VEGFA RASA1 KDR FLT1
7
TRAF Pathway 64
Show member pathways
 12.36 VEGFA KDR FLT1
8
Immune response Fc epsilon RI pathway 22
Show member pathways
 12.33 VEGFA RASA1 KDR
9
EPH-Ephrin signaling 66
Show member pathways
 12.16 VEGFA RASA1 MMP9 KDR
10
VEGF Pathway (Qiagen) 64
Show member pathways
 12.15 VEGFA KDR FLT1
11
RhoGDI Pathway 64
Show member pathways
 12.15 VEGFA KDR FLT1
12
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.15 VEGFA RASA1 KDR
13
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.14 RASA1 KDR FLT1
14
Proteoglycans in cancer 37
12.05 VEGFA MMP9 KDR
15
VEGF Signaling Pathway 67 61
Show member pathways
 11.99 VEGFA KDR FLT1
16
Fluid shear stress and atherosclerosis 37
11.83 VEGFA MMP9 KDR
17
SMAD Signaling Network 64
11.8 VEGFA KDR FLT1
18
S1P3 pathway 1
Show member pathways
 11.73 VEGFA KDR FLT1
19
EPHA forward signaling 1
Show member pathways
 11.71 VEGFA RASA1 KDR
20
HIF-1 signaling pathway 37
11.62 VEGFA SLC2A1 FLT1
21
VEGF Pathway (Tocris) 61
Show member pathways
 11.6 KDR FLT1
22
Validated targets of C-MYC transcriptional activation 1
11.59 SLC2A1 MMP9
23
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.57 VEGFA SLC2A1
24
Bladder cancer 37 1
11.54 VEGFA MMP9
25
Angiogenesis (CST) 4
11.49 MMP9 KDR FLT1
26
HIF-1-alpha transcription factor network 1
11.48 VEGFA SLC2A1
27
Endochondral Ossification 1
11.47 VEGFA MMP9
28
Transcription_P53 signaling pathway 22
11.46 VEGFA KDR FLT1
29
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.45 VEGFA MMP9
30
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.42 VEGFA RASA1 KDR FLT1
31
Celecoxib Pathway, Pharmacodynamics 61
11.41 VEGFA MMP9
32
HIF1Alpha Pathway 64
11.37 VEGFA SLC2A1
33
Cell adhesion_Plasmin signaling 22
11.32 VEGFA KDR
34
Integrins in angiogenesis 1
11.29 VEGFA KDR
35
Signaling events mediated by TCPTP 1
Show member pathways
 11.24 VEGFA KDR
36
Photodynamic therapy-induced HIF-1 survival signaling 1
11.17 VEGFA SLC2A1
37
Vemurafenib Pathway, Pharmacodynamics 61
11.07 VEGFA KDR FLT1
38
Glypican 1 network 1
10.99 VEGFA FLT1
39
Cytoskeleton remodeling_RalB regulation pathway 22
10.85 VEGFA KDR FLT1
40
HIF-2-alpha transcription factor network 1
10.79 VEGFA SLC2A1 KDR FLT1
41
Angiogenesis (WikiPathways) 1
10.3 VEGFA MMP9 KDR FLT1
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GO Terms for Angiokeratoma Circumscriptum

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Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 VEGFA KDR FLT1
2 positive regulation of protein phosphorylation GO:0001934 9.69 VEGFA MMP9 KDR
3 positive regulation of angiogenesis GO:0045766 9.65 VEGFA KDR FLT1
4 regulation of cell shape GO:0008360 9.63 VEGFA RASA1 KDR
5 ephrin receptor signaling pathway GO:0048013 9.62 RASA1 MMP9
6 positive regulation of endothelial cell proliferation GO:0001938 9.61 VEGFA KDR
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 KDR FLT1
8 positive regulation of MAP kinase activity GO:0043406 9.6 VEGFA FLT1
9 positive regulation of endothelial cell migration GO:0010595 9.59 VEGFA KDR
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 VEGFA KDR
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 VEGFA KDR
12 blood vessel morphogenesis GO:0048514 9.57 RASA1 FLT1
13 positive regulation of cell migration GO:0030335 9.56 VEGFA MMP9 KDR FLT1
14 positive regulation of focal adhesion assembly GO:0051894 9.55 VEGFA KDR
15 cell migration involved in sprouting angiogenesis GO:0002042 9.54 VEGFA KDR
16 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 VEGFA KDR FLT1
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.52 VEGFA FLT1
18 vasculogenesis GO:0001570 9.5 VEGFA RASA1 KDR
19 macrophage differentiation GO:0030225 9.49 VEGFA MMP9
20 positive regulation of positive chemotaxis GO:0050927 9.43 VEGFA KDR
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 VEGFA KDR
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.33 VEGFA KDR FLT1
23 negative regulation of apoptotic process GO:0043066 9.26 VEGFA RASA1 MMP9 KDR
24 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFA KDR FLT1

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 KDR FLT1
2 identical protein binding GO:0042802 9.26 VEGFA SLC2A1 MMP9 KDR
3 growth factor binding GO:0019838 9.16 KDR FLT1
4 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 KDR FLT1
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Sources for Angiokeratoma Circumscriptum

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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