MCID: ANG007
MIFTS: 36

Angiokeratoma Circumscriptum

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma Circumscriptum

MalaCards integrated aliases for Angiokeratoma Circumscriptum:

Name: Angiokeratoma Circumscriptum 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5949
NCIt 50 C7751
SNOMED-CT 68 21848000
UMLS 73 C0263638

Summaries for Angiokeratoma Circumscriptum

MalaCards based summary : Angiokeratoma Circumscriptum is related to hemangioma and angiokeratoma. An important gene associated with Angiokeratoma Circumscriptum is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are GPCR Pathway and Pathways in cancer. Affiliated tissues include tongue, skin and lung, and related phenotypes are Synthetic lethal with gemcitabine and cellular

Related Diseases for Angiokeratoma Circumscriptum

Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 hemangioma 30.1 FLT1 KDR SLC2A1 VEGFA
2 angiokeratoma 10.9
3 verrucous hemangioma 10.3
4 klippel-trenaunay-weber syndrome 10.1
5 melanoma 10.1
6 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.1 RASA1 SLC2A1
7 renal pelvis carcinoma 10.1 SLC2A1 VEGFA
8 glomeruloid hemangioma 10.1 FLT1 VEGFA
9 microcystic meningioma 10.1 FLT1 VEGFA
10 lipodermatosclerosis 10.1 FLT1 VEGFA
11 cancer-associated retinopathy 10.1 FLT1 VEGFA
12 acute mountain sickness 10.0 FLT1 VEGFA
13 hemangioblastoma 10.0 SLC2A1 VEGFA
14 radiation proctitis 10.0 KDR VEGFA
15 drug-induced lupus erythematosus 10.0 KDR VEGFA
16 angiomatous meningioma 10.0 KDR VEGFA
17 leukostasis 10.0 KDR VEGFA
18 lymphangioma 10.0 KDR VEGFA
19 coats disease 10.0 KDR VEGFA
20 epileptic encephalopathy, childhood-onset 10.0 KDR VEGFA
21 degeneration of macula and posterior pole 10.0 KDR VEGFA
22 breast carcinoma in situ 10.0 KDR VEGFA
23 limb ischemia 10.0 KDR VEGFA
24 supratentorial cancer 10.0 KDR VEGFA
25 cerebrum cancer 10.0 KDR VEGFA
26 ovarian hyperstimulation syndrome 10.0 KDR VEGFA
27 sick building syndrome 10.0 MMP9 VEGFA
28 adamantinous craniopharyngioma 10.0 MMP9 VEGFA
29 ischemic colitis 10.0 MMP9 VEGFA
30 odontogenic myxoma 10.0 MMP9 VEGFA
31 tuberculous meningitis 9.9 MMP9 VEGFA
32 rosacea 9.9 MMP9 VEGFA
33 alternating hemiplegia of childhood 9.9 MMP9 SLC2A1
34 nasopharyngeal disease 9.9 MMP9 VEGFA
35 pharynx cancer 9.9 MMP9 VEGFA
36 adenomyosis 9.9 MMP9 VEGFA
37 keratitis, hereditary 9.9 MMP9 VEGFA
38 epithelial basement membrane dystrophy 9.9 KDR MMP9
39 differentiated thyroid carcinoma 9.9 FLT1 VEGFA
40 severe pre-eclampsia 9.9 MMP9 VEGFA
41 arteriovenous malformations of the brain 9.9 KDR RASA1 VEGFA
42 chorioamnionitis 9.9 FLT1 MMP9
43 grade iii astrocytoma 9.9 MMP9 VEGFA
44 varicose veins 9.9 MMP9 VEGFA
45 male reproductive organ cancer 9.9 MMP9 VEGFA
46 brain edema 9.9 MMP9 VEGFA
47 clear cell renal cell carcinoma 9.9 KDR SLC2A1 VEGFA
48 epithelioid hemangioendothelioma 9.9 FLT1 KDR VEGFA
49 vascular cancer 9.9 FLT1 KDR VEGFA
50 corneal neovascularization 9.8 FLT1 KDR VEGFA

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:



Diseases related to Angiokeratoma Circumscriptum

Symptoms & Phenotypes for Angiokeratoma Circumscriptum

GenomeRNAi Phenotypes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
2 cardiovascular system MP:0005385 9.83 FLT1 KDR MMP9 RASA1 VEGFA
3 growth/size/body region MP:0005378 9.8 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
4 embryo MP:0005380 9.77 FLT1 KDR RASA1 SLC2A1 VEGFA
5 mortality/aging MP:0010768 9.73 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
6 muscle MP:0005369 9.55 FLT1 KDR MMP9 RASA1 VEGFA
7 nervous system MP:0003631 9.43 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
8 no phenotypic analysis MP:0003012 8.92 KDR RASA1 SLC2A1 VEGFA

Drugs & Therapeutics for Angiokeratoma Circumscriptum

Search Clinical Trials , NIH Clinical Center for Angiokeratoma Circumscriptum

Genetic Tests for Angiokeratoma Circumscriptum

Anatomical Context for Angiokeratoma Circumscriptum

MalaCards organs/tissues related to Angiokeratoma Circumscriptum:

41
Tongue, Skin, Lung, Brain, Breast, Pancreas, Thyroid

Publications for Angiokeratoma Circumscriptum

Articles related to Angiokeratoma Circumscriptum:

(show all 40)
# Title Authors Year
1
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. ( 30156622 )
2018
2
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
3
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2016
4
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
5
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
6
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
7
Angiokeratoma circumscriptum: dilemma in diagnosis. ( 24943793 )
2014
8
Angiokeratoma circumscriptum in a young male. ( 24470669 )
2014
9
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
10
Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. ( 23288806 )
2012
11
Angiokeratoma circumscriptum neviforme. ( 22318117 )
2012
12
Angiokeratoma circumscriptum of the tongue. ( 22565076 )
2012
13
Angiokeratoma circumscriptum of the tongue. ( 21463157 )
2011
14
A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. ( 22279389 )
2011
15
Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. ( 21971276 )
2011
16
A case of post-injury angiokeratoma circumscriptum of the chest. ( 20548886 )
2010
17
A case of solitary angiokeratoma circumscriptum of the tongue. ( 18187999 )
2007
18
Angiokeratoma circumscriptum of the penis. ( 16536830 )
2006
19
Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. ( 16848823 )
2006
20
Angiokeratoma circumscriptum of the tongue. ( 16207201 )
2005
21
Angiokeratoma circumscriptum: a case report and review of the literature. ( 16409270 )
2005
22
Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. ( 15762221 )
2005
23
Angiokeratoma circumscriptum. ( 15458538 )
2004
24
Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. ( 15347502 )
2004
25
Angiokeratoma circumscriptum of the tongue. ( 12657024 )
2003
26
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. ( 11903167 )
2001
27
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. ( 9675347 )
1998
28
Angiokeratoma circumscriptum of the oral cavity. ( 9833054 )
1998
29
Verrucous hemangioma and angiokeratoma circumscriptum: clinical and histologic differential characteristics. ( 2910968 )
1989
30
Angiokeratoma Circumscriptum. ( 28128171 )
1989
31
Hemangiectatic hypertrophy with angiokeratoma circumscriptum. ( 2831161 )
1988
32
Angiokeratoma circumscriptum: successful treatment with the argon laser. ( 3281548 )
1988
33
Spontaneous Bleeding, Cornu Cutaneum, Nevus Flammeus in Angiokeratoma Circumscriptum. ( 28145316 )
1987
34
Angiokeratoma circumscriptum following damage to underlying vasculature. ( 3954388 )
1986
35
Thrombotic angiokeratoma circumscriptum simulating melanoma. ( 6782953 )
1981
36
Angiokeratoma circumscriptum of the index finger in a child. ( 7465672 )
1981
37
Angiokeratoma Circumscriptum. ( 28223639 )
1979
38
Angiokeratoma circumscriptum. ( 5431571 )
1970
39
Angiokeratoma circumscriptum. ( 6075783 )
1967
40
Angiokeratoma circumscriptum and angiokeratoma scroti. Report of a case. ( 13805123 )
1960

Variations for Angiokeratoma Circumscriptum

Expression for Angiokeratoma Circumscriptum

Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.

Pathways for Angiokeratoma Circumscriptum

Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.39 FLT1 KDR MMP9 RASA1 VEGFA
2 12.59 MMP9 SLC2A1 VEGFA
3
Show member pathways
12.52 KDR MMP9 VEGFA
4 12.45 FLT1 KDR RASA1 VEGFA
5
Show member pathways
12.4 KDR MMP9 VEGFA
6
Show member pathways
12.4 FLT1 KDR RASA1 VEGFA
7
Show member pathways
12.37 FLT1 KDR VEGFA
8
Show member pathways
12.34 KDR RASA1 VEGFA
9
Show member pathways
12.21 KDR MMP9 RASA1 VEGFA
10
Show member pathways
12.16 FLT1 KDR VEGFA
11
Show member pathways
12.15 FLT1 KDR RASA1
12
Show member pathways
12.15 FLT1 KDR VEGFA
13
Show member pathways
12.15 KDR RASA1 VEGFA
14 12.06 KDR MMP9 VEGFA
15
Show member pathways
12 FLT1 KDR VEGFA
16 11.84 KDR MMP9 VEGFA
17 11.82 FLT1 KDR VEGFA
18
Show member pathways
11.75 KDR RASA1 VEGFA
19
Show member pathways
11.73 FLT1 KDR VEGFA
20 11.61 FLT1 SLC2A1 VEGFA
21 11.6 MMP9 SLC2A1
22
Show member pathways
11.6 FLT1 KDR
23 11.58 SLC2A1 VEGFA
24
Show member pathways
11.57 FLT1 KDR
25 11.54 MMP9 VEGFA
26 11.53 FLT1 KDR MMP9
27 11.48 MMP9 VEGFA
28 11.48 SLC2A1 VEGFA
29 11.46 FLT1 KDR VEGFA
30
Show member pathways
11.45 MMP9 VEGFA
31
Show member pathways
11.42 FLT1 KDR RASA1 VEGFA
32 11.41 MMP9 VEGFA
33 11.38 SLC2A1 VEGFA
34 11.33 KDR VEGFA
35 11.3 KDR VEGFA
36
Show member pathways
11.25 KDR VEGFA
37 11.17 SLC2A1 VEGFA
38 11.12 FLT1 KDR VEGFA
39 11 FLT1 VEGFA
40 10.86 FLT1 KDR VEGFA
41 10.79 FLT1 KDR SLC2A1 VEGFA
42
Show member pathways
10.64 FLT1 KDR VEGFA
43 10.3 FLT1 KDR MMP9 VEGFA

GO Terms for Angiokeratoma Circumscriptum

Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 FLT1 KDR VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.69 KDR MMP9 VEGFA
3 positive regulation of angiogenesis GO:0045766 9.65 FLT1 KDR VEGFA
4 regulation of cell shape GO:0008360 9.63 KDR RASA1 VEGFA
5 ephrin receptor signaling pathway GO:0048013 9.62 MMP9 RASA1
6 positive regulation of endothelial cell proliferation GO:0001938 9.61 KDR VEGFA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 FLT1 KDR
8 positive regulation of MAP kinase activity GO:0043406 9.6 FLT1 VEGFA
9 positive regulation of endothelial cell migration GO:0010595 9.59 KDR VEGFA
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 KDR VEGFA
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 KDR VEGFA
12 blood vessel morphogenesis GO:0048514 9.57 FLT1 RASA1
13 positive regulation of cell migration GO:0030335 9.56 FLT1 KDR MMP9 VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
15 cell migration involved in sprouting angiogenesis GO:0002042 9.54 KDR VEGFA
16 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT1 KDR VEGFA
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.52 FLT1 VEGFA
18 vasculogenesis GO:0001570 9.5 KDR RASA1 VEGFA
19 macrophage differentiation GO:0030225 9.49 MMP9 VEGFA
20 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
22 negative regulation of apoptotic process GO:0043066 9.35 FLT1 KDR MMP9 RASA1 VEGFA
23 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.33 FLT1 KDR VEGFA
24 vascular endothelial growth factor signaling pathway GO:0038084 8.8 FLT1 KDR VEGFA

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 FLT1 KDR
2 identical protein binding GO:0042802 9.26 KDR MMP9 SLC2A1 VEGFA
3 growth factor binding GO:0019838 9.16 FLT1 KDR
4 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 KDR

Sources for Angiokeratoma Circumscriptum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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