MCID: ANG007
MIFTS: 32

Angiokeratoma Circumscriptum

Categories: Cancer diseases

Aliases & Classifications for Angiokeratoma Circumscriptum

MalaCards integrated aliases for Angiokeratoma Circumscriptum:

Name: Angiokeratoma Circumscriptum 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5949
NCIt 50 C7751
SNOMED-CT 68 21848000
UMLS 73 C0263638

Summaries for Angiokeratoma Circumscriptum

MalaCards based summary : Angiokeratoma Circumscriptum is related to hemangioma and angiokeratoma. An important gene associated with Angiokeratoma Circumscriptum is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are GPCR Pathway and Pathways in cancer. Affiliated tissues include tongue, and related phenotypes are Synthetic lethal with gemcitabine and cellular

Related Diseases for Angiokeratoma Circumscriptum

Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 hemangioma 29.6 KDR SLC2A1 VEGFA
2 angiokeratoma 10.8
3 renal pelvis carcinoma 10.3 SLC2A1 VEGFA
4 telangiectasis 10.3 RASA1 VEGFA
5 glomeruloid hemangioma 10.2 FLT1 VEGFA
6 lipodermatosclerosis 10.2 FLT1 VEGFA
7 cancer-associated retinopathy 10.2 FLT1 VEGFA
8 peripartum cardiomyopathy 10.2 FLT1 VEGFA
9 acute mountain sickness 10.1 FLT1 VEGFA
10 hemangioblastoma 10.1 SLC2A1 VEGFA
11 radiation proctitis 10.1 KDR VEGFA
12 kuhnt-junius degeneration 10.1 KDR VEGFA
13 angiomatous meningioma 10.1 KDR VEGFA
14 leukostasis 10.1 KDR VEGFA
15 lymphangioma 10.0 KDR VEGFA
16 coats disease 10.0 KDR VEGFA
17 klippel-trenaunay-weber syndrome 10.0
18 melanoma 10.0
19 verrucous hemangioma 10.0
20 degeneration of macula and posterior pole 10.0 KDR VEGFA
21 epileptic encephalopathy, childhood-onset 10.0 KDR VEGFA
22 limb ischemia 10.0 KDR VEGFA
23 ovarian hyperstimulation syndrome 10.0 KDR VEGFA
24 sick building syndrome 9.9 MMP9 VEGFA
25 adamantinous craniopharyngioma 9.9 MMP9 VEGFA
26 differentiated thyroid carcinoma 9.9 SLC2A1 VEGFA
27 adenomyosis 9.8 MMP9 VEGFA
28 odontogenic myxoma 9.8 MMP9 VEGFA
29 tuberculous meningitis 9.8 MMP9 VEGFA
30 rosacea 9.8 MMP9 VEGFA
31 alternating hemiplegia of childhood 9.8 MMP9 SLC2A1
32 pharynx cancer 9.7 MMP9 VEGFA
33 keratitis, hereditary 9.7 MMP9 VEGFA
34 chorioamnionitis 9.7 FLT1 MMP9
35 severe pre-eclampsia 9.7 MMP9 VEGFA
36 arteriovenous malformations of the brain 9.6 KDR RASA1 VEGFA
37 grade iii astrocytoma 9.6 MMP9 VEGFA
38 brain edema 9.6 MMP9 VEGFA
39 varicose veins 9.6 MMP9 VEGFA
40 clear cell renal cell carcinoma 9.6 KDR SLC2A1 VEGFA
41 male reproductive organ cancer 9.6 MMP9 VEGFA
42 epithelioid hemangioendothelioma 9.5 FLT1 KDR VEGFA
43 acute hemorrhagic leukoencephalitis 9.5 FLT1 KDR VEGFA
44 vascular cancer 9.5 FLT1 KDR VEGFA
45 female reproductive organ cancer 9.5 MMP9 VEGFA
46 breast carcinoma in situ 9.5 FLT1 KDR VEGFA
47 corneal neovascularization 9.5 FLT1 KDR VEGFA
48 placental insufficiency 9.5 FLT1 KDR VEGFA
49 angiosarcoma 9.5 FLT1 KDR VEGFA
50 retinal vascular disease 9.5 FLT1 KDR VEGFA

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:



Diseases related to Angiokeratoma Circumscriptum

Symptoms & Phenotypes for Angiokeratoma Circumscriptum

GenomeRNAi Phenotypes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 SLC2A1 FLT1 VEGFA KDR MMP9 RASA1
2 cardiovascular system MP:0005385 9.83 RASA1 FLT1 VEGFA KDR MMP9
3 growth/size/body region MP:0005378 9.8 SLC2A1 FLT1 VEGFA KDR MMP9 RASA1
4 embryo MP:0005380 9.77 SLC2A1 FLT1 VEGFA KDR RASA1
5 mortality/aging MP:0010768 9.73 RASA1 SLC2A1 FLT1 VEGFA KDR MMP9
6 muscle MP:0005369 9.55 FLT1 VEGFA KDR MMP9 RASA1
7 nervous system MP:0003631 9.43 SLC2A1 FLT1 VEGFA KDR MMP9 RASA1
8 no phenotypic analysis MP:0003012 8.92 RASA1 SLC2A1 VEGFA KDR

Drugs & Therapeutics for Angiokeratoma Circumscriptum

Search Clinical Trials , NIH Clinical Center for Angiokeratoma Circumscriptum

Genetic Tests for Angiokeratoma Circumscriptum

Anatomical Context for Angiokeratoma Circumscriptum

MalaCards organs/tissues related to Angiokeratoma Circumscriptum:

41
Tongue

Publications for Angiokeratoma Circumscriptum

Articles related to Angiokeratoma Circumscriptum:

(show all 36)
# Title Authors Year
1
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
2
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2016
3
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
4
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
5
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
6
Angiokeratoma circumscriptum: dilemma in diagnosis. ( 24943793 )
2014
7
Angiokeratoma circumscriptum in a young male. ( 24470669 )
2014
8
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
9
Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. ( 23288806 )
2012
10
Angiokeratoma circumscriptum neviforme. ( 22318117 )
2012
11
Angiokeratoma circumscriptum of the tongue. ( 22565076 )
2012
12
Angiokeratoma circumscriptum of the tongue. ( 21463157 )
2011
13
A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. ( 22279389 )
2011
14
Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. ( 21971276 )
2011
15
A case of post-injury angiokeratoma circumscriptum of the chest. ( 20548886 )
2010
16
A case of solitary angiokeratoma circumscriptum of the tongue. ( 18187999 )
2007
17
Angiokeratoma circumscriptum of the penis. ( 16536830 )
2006
18
Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. ( 16848823 )
2006
19
Angiokeratoma circumscriptum of the tongue. ( 16207201 )
2005
20
Angiokeratoma circumscriptum: a case report and review of the literature. ( 16409270 )
2005
21
Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. ( 15762221 )
2005
22
Angiokeratoma circumscriptum. ( 15458538 )
2004
23
Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. ( 15347502 )
2004
24
Angiokeratoma circumscriptum of the tongue. ( 12657024 )
2003
25
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. ( 11903167 )
2001
26
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. ( 9675347 )
1998
27
Angiokeratoma circumscriptum of the oral cavity. ( 9833054 )
1998
28
Verrucous hemangioma and angiokeratoma circumscriptum: clinical and histologic differential characteristics. ( 2910968 )
1989
29
Hemangiectatic hypertrophy with angiokeratoma circumscriptum. ( 2831161 )
1988
30
Angiokeratoma circumscriptum: successful treatment with the argon laser. ( 3281548 )
1988
31
Angiokeratoma circumscriptum following damage to underlying vasculature. ( 3954388 )
1986
32
Thrombotic angiokeratoma circumscriptum simulating melanoma. ( 6782953 )
1981
33
Angiokeratoma circumscriptum of the index finger in a child. ( 7465672 )
1981
34
Angiokeratoma circumscriptum. ( 5431571 )
1970
35
Angiokeratoma circumscriptum. ( 6075783 )
1967
36
Angiokeratoma circumscriptum and angiokeratoma scroti. Report of a case. ( 13805123 )
1960

Variations for Angiokeratoma Circumscriptum

Expression for Angiokeratoma Circumscriptum

Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.

Pathways for Angiokeratoma Circumscriptum

Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 FLT1 KDR MMP9 RASA1 VEGFA
2 12.58 MMP9 SLC2A1 VEGFA
3
Show member pathways
12.51 KDR MMP9 VEGFA
4 12.45 FLT1 KDR RASA1 VEGFA
5
Show member pathways
12.4 FLT1 KDR RASA1 VEGFA
6
Show member pathways
12.39 KDR MMP9 VEGFA
7
Show member pathways
12.32 KDR RASA1 VEGFA
8
Show member pathways
12.21 KDR MMP9 RASA1 VEGFA
9
Show member pathways
12.15 FLT1 KDR VEGFA
10
Show member pathways
12.14 FLT1 KDR VEGFA
11
Show member pathways
12.14 KDR RASA1 VEGFA
12 12.04 KDR MMP9 VEGFA
13
Show member pathways
11.98 FLT1 KDR VEGFA
14
Show member pathways
11.85 FLT1 KDR
15 11.84 KDR MMP9 VEGFA
16 11.8 FLT1 KDR VEGFA
17
Show member pathways
11.75 KDR RASA1 VEGFA
18
Show member pathways
11.73 FLT1 KDR VEGFA
19 11.61 FLT1 SLC2A1 VEGFA
20
Show member pathways
11.6 FLT1 KDR
21 11.58 MMP9 SLC2A1
22 11.57 SLC2A1 VEGFA
23 11.53 MMP9 VEGFA
24 11.53 FLT1 KDR MMP9
25 11.47 MMP9 VEGFA
26 11.47 SLC2A1 VEGFA
27
Show member pathways
11.45 MMP9 VEGFA
28
Show member pathways
11.44 FLT1 KDR
29
Show member pathways
11.42 FLT1 KDR RASA1 VEGFA
30 11.41 MMP9 VEGFA
31 11.37 SLC2A1 VEGFA
32 11.32 KDR VEGFA
33 11.29 KDR VEGFA
34
Show member pathways
11.23 KDR VEGFA
35 11.16 SLC2A1 VEGFA
36 11.12 FLT1 KDR VEGFA
37 10.98 FLT1 VEGFA
38 10.79 FLT1 KDR SLC2A1 VEGFA
39
Show member pathways
10.64 FLT1 KDR VEGFA
40 10.3 FLT1 KDR MMP9 VEGFA

GO Terms for Angiokeratoma Circumscriptum

Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 FLT1 KDR VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.69 KDR MMP9 VEGFA
3 regulation of cell shape GO:0008360 9.65 KDR RASA1 VEGFA
4 positive regulation of angiogenesis GO:0045766 9.63 FLT1 KDR VEGFA
5 positive regulation of kinase activity GO:0033674 9.62 FLT1 KDR
6 positive regulation of endothelial cell proliferation GO:0001938 9.61 KDR VEGFA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 FLT1 KDR
8 positive regulation of MAP kinase activity GO:0043406 9.6 FLT1 VEGFA
9 positive regulation of endothelial cell migration GO:0010595 9.59 KDR VEGFA
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 KDR VEGFA
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 KDR VEGFA
12 blood vessel morphogenesis GO:0048514 9.57 FLT1 RASA1
13 positive regulation of cell migration GO:0030335 9.56 FLT1 KDR MMP9 VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
15 negative regulation of apoptotic process GO:0043066 9.55 FLT1 KDR MMP9 RASA1 VEGFA
16 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.54 FLT1 VEGFA
17 macrophage differentiation GO:0030225 9.52 MMP9 VEGFA
18 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.5 FLT1 KDR VEGFA
19 cell migration involved in sprouting angiogenesis GO:0002042 9.49 KDR VEGFA
20 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
21 vascular endothelial growth factor signaling pathway GO:0038084 9.4 FLT1 KDR
22 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.37 KDR VEGFA
23 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.13 FLT1 KDR VEGFA
24 vasculogenesis GO:0001570 8.92 FLT1 KDR RASA1 VEGFA

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.37 FLT1 KDR
2 mitogen-activated protein kinase kinase binding GO:0031434 9.32 FLT1 KDR
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 FLT1 KDR
4 identical protein binding GO:0042802 9.26 KDR MMP9 SLC2A1 VEGFA
5 growth factor binding GO:0019838 9.16 FLT1 KDR
6 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 KDR

Sources for Angiokeratoma Circumscriptum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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