MCID: ANG007
MIFTS: 36

Angiokeratoma Circumscriptum

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma Circumscriptum

MalaCards integrated aliases for Angiokeratoma Circumscriptum:

Name: Angiokeratoma Circumscriptum 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5949
NCIt 51 C7751
SNOMED-CT 69 21848000
UMLS 74 C0263638

Summaries for Angiokeratoma Circumscriptum

MalaCards based summary : Angiokeratoma Circumscriptum is related to hemangioma and angiokeratoma. An important gene associated with Angiokeratoma Circumscriptum is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are GPCR Pathway and Pathways in cancer. Affiliated tissues include skin, tongue and brain, and related phenotypes are Synthetic lethal with gemcitabine and cellular

Related Diseases for Angiokeratoma Circumscriptum

Diseases related to Angiokeratoma Circumscriptum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 hemangioma 29.9 FLT1 KDR SLC2A1 VEGFA
2 angiokeratoma 11.0
3 verrucous hemangioma 10.3
4 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.2 RASA1 SLC2A1
5 klippel-trenaunay-weber syndrome 10.2
6 neutrophil migration 10.2
7 human venous malformation 10.2
8 melanoma 10.2
9 renal pelvis carcinoma 10.1 SLC2A1 VEGFA
10 glomeruloid hemangioma 10.1 FLT1 VEGFA
11 microcystic meningioma 10.1 FLT1 VEGFA
12 lipodermatosclerosis 10.1 FLT1 VEGFA
13 cancer-associated retinopathy 10.1 FLT1 VEGFA
14 acute mountain sickness 10.1 FLT1 VEGFA
15 breast carcinoma in situ 10.1 FLT1 VEGFA
16 radiation proctitis 10.0 KDR VEGFA
17 hemangioblastoma 10.0 SLC2A1 VEGFA
18 placenta accreta 10.0 FLT1 KDR
19 drug-induced lupus erythematosus 10.0 KDR VEGFA
20 angiomatous meningioma 10.0 KDR VEGFA
21 leukostasis 10.0 KDR VEGFA
22 lymphangioma 10.0 KDR VEGFA
23 coats disease 10.0 KDR VEGFA
24 epileptic encephalopathy, childhood-onset 10.0 KDR VEGFA
25 degeneration of macula and posterior pole 10.0 KDR VEGFA
26 limb ischemia 10.0 KDR VEGFA
27 supratentorial cancer 10.0 KDR VEGFA
28 cerebrum cancer 10.0 KDR VEGFA
29 ovarian hyperstimulation syndrome 10.0 KDR VEGFA
30 sick building syndrome 9.9 MMP9 VEGFA
31 adamantinous craniopharyngioma 9.9 MMP9 VEGFA
32 ischemic colitis 9.9 MMP9 VEGFA
33 odontogenic myxoma 9.9 MMP9 VEGFA
34 tuberculous meningitis 9.9 MMP9 VEGFA
35 rosacea 9.9 MMP9 VEGFA
36 nasopharyngeal disease 9.9 MMP9 VEGFA
37 alternating hemiplegia of childhood 9.9 MMP9 SLC2A1
38 pharynx cancer 9.9 MMP9 VEGFA
39 adenomyosis 9.9 MMP9 VEGFA
40 epithelial basement membrane dystrophy 9.9 KDR MMP9
41 keratitis, hereditary 9.9 MMP9 VEGFA
42 severe pre-eclampsia 9.8 MMP9 VEGFA
43 arteriovenous malformations of the brain 9.8 KDR RASA1 VEGFA
44 chorioamnionitis 9.8 FLT1 MMP9
45 grade iii astrocytoma 9.8 MMP9 VEGFA
46 varicose veins 9.8 MMP9 VEGFA
47 male reproductive organ cancer 9.8 MMP9 VEGFA
48 clear cell renal cell carcinoma 9.8 KDR SLC2A1 VEGFA
49 brain edema 9.8 MMP9 VEGFA
50 epithelioid hemangioendothelioma 9.8 FLT1 KDR VEGFA

Graphical network of the top 20 diseases related to Angiokeratoma Circumscriptum:



Diseases related to Angiokeratoma Circumscriptum

Symptoms & Phenotypes for Angiokeratoma Circumscriptum

GenomeRNAi Phenotypes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

MGI Mouse Phenotypes related to Angiokeratoma Circumscriptum:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
2 cardiovascular system MP:0005385 9.83 FLT1 KDR MMP9 RASA1 VEGFA
3 growth/size/body region MP:0005378 9.8 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
4 embryo MP:0005380 9.77 FLT1 KDR RASA1 SLC2A1 VEGFA
5 mortality/aging MP:0010768 9.73 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
6 muscle MP:0005369 9.55 FLT1 KDR MMP9 RASA1 VEGFA
7 nervous system MP:0003631 9.43 FLT1 KDR MMP9 RASA1 SLC2A1 VEGFA
8 no phenotypic analysis MP:0003012 8.92 KDR RASA1 SLC2A1 VEGFA

Drugs & Therapeutics for Angiokeratoma Circumscriptum

Search Clinical Trials , NIH Clinical Center for Angiokeratoma Circumscriptum

Genetic Tests for Angiokeratoma Circumscriptum

Anatomical Context for Angiokeratoma Circumscriptum

MalaCards organs/tissues related to Angiokeratoma Circumscriptum:

42
Skin, Tongue, Brain, Lung, Breast, Thyroid, Placenta

Publications for Angiokeratoma Circumscriptum

Articles related to Angiokeratoma Circumscriptum:

(show all 41)
# Title Authors Year
1
Verrucous hemangioma and histopathological differential diagnosis with angiokeratoma circumscriptum neviforme. ( 30156622 )
2018
2
Successful treatment of angiokeratoma circumscriptum naeviforme with long pulse alexandrite laser. ( 27511129 )
2017
3
Extensive angiokeratoma circumscriptum - successful treatment with 595-nm variable-pulse pulsed dye laser and 755-nm long-pulse pulsed alexandrite laser. ( 26736060 )
2016
4
Angiokeratoma circumscriptum naeviforme with soft tissue hypertrophy and deep venous malformation: A variant of Klippel-Trenaunay syndrome? ( 25593797 )
2014
5
Angiokeratoma circumscriptum in a young male. ( 24470669 )
2014
6
Angiokeratoma circumscriptum: dilemma in diagnosis. ( 24943793 )
2014
7
Late onset palmar angiokeratoma circumscriptum: An unusual presentation. ( 25165655 )
2014
8
Angiokeratoma circumscriptum of the buccal mucosa: a case report and literature review. ( 25368837 )
2014
9
Angiokeratoma circumscriptum neviforme: An entity, few and far between. ( 25396132 )
2014
10
Angiokeratoma circumscriptum neviforme. ( 22318117 )
2012
11
Angiokeratoma circumscriptum of the tongue. ( 22565076 )
2012
12
Development of hemangioma in a tongue harboring long-standing angiokeratoma circumscriptum. ( 23288806 )
2012
13
Angiokeratoma circumscriptum of the tongue. ( 21463157 )
2011
14
Angiokeratoma circumscriptum naeviforme: a case report of a rare disease. ( 21971276 )
2011
15
A case of angiokeratoma circumscriptum of the tongue: response with carbon dioxide and pulsed dye laser. ( 22279389 )
2011
16
A case of post-injury angiokeratoma circumscriptum of the chest. ( 20548886 )
2010
17
A case of solitary angiokeratoma circumscriptum of the tongue. ( 18187999 )
2007
18
Angiokeratoma circumscriptum of the penis. ( 16536830 )
2006
19
Angiokeratoma circumscriptum arranged in a systematized band-like pattern suggesting mosaicism. ( 16848823 )
2006
20
Angiokeratoma circumscriptum of the tongue. ( 16207201 )
2005
21
Angiokeratoma circumscriptum: a case report and review of the literature. ( 16409270 )
2005
22
Angiokeratoma circumscriptum naeviforme: successful treatment with carbon-dioxide laser vaporization. ( 15762221 )
2005
23
Cutaneous variant of angiokeratoma corporis diffusum associated with angiokeratoma circumscriptum. ( 15347502 )
2004
24
Angiokeratoma circumscriptum. ( 15458538 )
2004
25
Angiokeratoma circumscriptum of the tongue. ( 12657024 )
2003
26
Angiokeratoma circumscriptum naeviforme: rare presentation on the neck. ( 11903167 )
2001
27
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9. ( 9675347 )
1998
28
Angiokeratoma circumscriptum of the oral cavity. ( 9833054 )
1998
29
Verrucous hemangioma and angiokeratoma circumscriptum: clinical and histologic differential characteristics. ( 2910968 )
1989
30
Angiokeratoma Circumscriptum. ( 28128171 )
1989
31
Hemangiectatic hypertrophy with angiokeratoma circumscriptum. ( 2831161 )
1988
32
Angiokeratoma circumscriptum: successful treatment with the argon laser. ( 3281548 )
1988
33
Spontaneous Bleeding, Cornu Cutaneum, Nevus Flammeus in Angiokeratoma Circumscriptum. ( 28145316 )
1987
34
Angiokeratoma circumscriptum following damage to underlying vasculature. ( 3954388 )
1986
35
Thrombotic angiokeratoma circumscriptum simulating melanoma. ( 6782953 )
1981
36
Angiokeratoma circumscriptum of the index finger in a child. ( 7465672 )
1981
37
Angiokeratoma Circumscriptum. ( 28223639 )
1979
38
Angiokeratoma "Circumscriptum". ( 4639261 )
1972
39
Angiokeratoma circumscriptum. ( 5431571 )
1970
40
Angiokeratoma circumscriptum. ( 6075783 )
1967
41
Angiokeratoma circumscriptum and angiokeratoma scroti. Report of a case. ( 13805123 )
1960

Variations for Angiokeratoma Circumscriptum

Expression for Angiokeratoma Circumscriptum

Search GEO for disease gene expression data for Angiokeratoma Circumscriptum.

Pathways for Angiokeratoma Circumscriptum

Pathways related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 FLT1 KDR MMP9 RASA1 VEGFA
2 12.59 MMP9 SLC2A1 VEGFA
3
Show member pathways
12.44 KDR MMP9 VEGFA
4 12.43 FLT1 KDR RASA1 VEGFA
5
Show member pathways
12.4 KDR MMP9 VEGFA
6
Show member pathways
12.38 FLT1 KDR RASA1 VEGFA
7
Show member pathways
12.36 FLT1 KDR VEGFA
8
Show member pathways
12.33 KDR RASA1 VEGFA
9
Show member pathways
12.16 KDR MMP9 RASA1 VEGFA
10
Show member pathways
12.15 FLT1 KDR VEGFA
11
Show member pathways
12.15 FLT1 KDR VEGFA
12
Show member pathways
12.15 KDR RASA1 VEGFA
13
Show member pathways
12.14 FLT1 KDR RASA1
14 12.05 KDR MMP9 VEGFA
15
Show member pathways
11.99 FLT1 KDR VEGFA
16 11.83 KDR MMP9 VEGFA
17 11.81 FLT1 KDR VEGFA
18
Show member pathways
11.73 KDR RASA1 VEGFA
19
Show member pathways
11.71 FLT1 KDR VEGFA
20 11.59 MMP9 SLC2A1
21
Show member pathways
11.59 FLT1 KDR
22 11.58 SLC2A1 VEGFA
23 11.58 FLT1 SLC2A1 VEGFA
24 11.54 MMP9 VEGFA
25 11.49 FLT1 KDR MMP9
26 11.48 MMP9 VEGFA
27 11.47 SLC2A1 VEGFA
28
Show member pathways
11.45 MMP9 VEGFA
29 11.44 FLT1 KDR VEGFA
30
Show member pathways
11.42 FLT1 KDR RASA1 VEGFA
31 11.41 MMP9 VEGFA
32 11.37 SLC2A1 VEGFA
33 11.32 KDR VEGFA
34 11.29 KDR VEGFA
35
Show member pathways
11.24 KDR VEGFA
36 11.17 SLC2A1 VEGFA
37 11.07 FLT1 KDR VEGFA
38 10.99 FLT1 VEGFA
39 10.85 FLT1 KDR VEGFA
40 10.79 FLT1 KDR SLC2A1 VEGFA
41 10.3 FLT1 KDR MMP9 VEGFA

GO Terms for Angiokeratoma Circumscriptum

Biological processes related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 FLT1 KDR VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.69 KDR MMP9 VEGFA
3 positive regulation of angiogenesis GO:0045766 9.65 FLT1 KDR VEGFA
4 regulation of cell shape GO:0008360 9.63 KDR RASA1 VEGFA
5 ephrin receptor signaling pathway GO:0048013 9.62 MMP9 RASA1
6 positive regulation of endothelial cell proliferation GO:0001938 9.61 KDR VEGFA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.61 FLT1 KDR
8 positive regulation of MAP kinase activity GO:0043406 9.6 FLT1 VEGFA
9 positive regulation of endothelial cell migration GO:0010595 9.59 KDR VEGFA
10 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 KDR VEGFA
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.58 KDR VEGFA
12 blood vessel morphogenesis GO:0048514 9.57 FLT1 RASA1
13 positive regulation of cell migration GO:0030335 9.56 FLT1 KDR MMP9 VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
15 cell migration involved in sprouting angiogenesis GO:0002042 9.54 KDR VEGFA
16 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.54 FLT1 KDR VEGFA
17 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.52 FLT1 VEGFA
18 vasculogenesis GO:0001570 9.5 KDR RASA1 VEGFA
19 macrophage differentiation GO:0030225 9.49 MMP9 VEGFA
20 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
22 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.33 FLT1 KDR VEGFA
23 negative regulation of apoptotic process GO:0043066 9.26 KDR MMP9 RASA1 VEGFA
24 vascular endothelial growth factor signaling pathway GO:0038084 8.8 FLT1 KDR VEGFA

Molecular functions related to Angiokeratoma Circumscriptum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 FLT1 KDR
2 identical protein binding GO:0042802 9.26 KDR MMP9 SLC2A1 VEGFA
3 growth factor binding GO:0019838 9.16 FLT1 KDR
4 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT1 KDR

Sources for Angiokeratoma Circumscriptum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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