MCID: ANG014
MIFTS: 26

Angiokeratoma of Fordyce

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Angiokeratoma of Fordyce

MalaCards integrated aliases for Angiokeratoma of Fordyce:

Name: Angiokeratoma of Fordyce 12 15 70
Fordyce-Type Angiokeratoma of Scrotum 12
Fordyce Angiokeratoma 12
Fordyce's Spot 12

Classifications:



External Ids:

Disease Ontology 12 DOID:664
NCIt 50 C7752
SNOMED-CT 67 254789007
UMLS 70 C0263639

Summaries for Angiokeratoma of Fordyce

MalaCards based summary : Angiokeratoma of Fordyce, also known as fordyce-type angiokeratoma of scrotum, is related to angiokeratoma and hemangioma. An important gene associated with Angiokeratoma of Fordyce is PROX1 (Prospero Homeobox 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Angiogenesis (CST). Related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Angiokeratoma of Fordyce

Diseases related to Angiokeratoma of Fordyce via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 angiokeratoma 31.4 GLA ACE
2 hemangioma 29.0 PROX1 PECAM1 MMP9 GNAQ FLT1
3 vulvar angiokeratoma 11.2
4 keratosis 10.3
5 purpura 10.3
6 acquired hemangioma 10.2 PROX1 PECAM1
7 intramuscular hemangioma 10.2 PROX1 PECAM1
8 focal epithelial hyperplasia 10.2 TMC8 TMC6
9 breast angiosarcoma 10.2 PROX1 PECAM1
10 kaposiform hemangioendothelioma 10.2 PROX1 PECAM1
11 capillary lymphangioma 10.2 PROX1 PECAM1
12 lymphangiosarcoma 10.2 PROX1 PECAM1
13 plantar wart 10.2 TMC8 TMC6
14 common wart 10.2 TMC8 TMC6
15 lymphangitis 10.2 PROX1 PECAM1
16 pityriasis versicolor 10.2 TMC8 TMC6
17 superficial mycosis 10.2 TMC8 TMC6
18 malignant ciliary body melanoma 10.2 PROX1 FLT1
19 ciliary body cancer 10.2 PROX1 FLT1
20 hobnail hemangioma 10.2 WT1 PECAM1
21 cystic lymphangioma 10.2 PROX1 PECAM1
22 ovarian endometrioid stromal sarcoma 10.2 WT1 PECAM1
23 anogenital venereal wart 10.2 TMC8 TMC6
24 benign peritoneal mesothelioma 10.1 WT1 PECAM1
25 fabry disease 10.1
26 penile cancer 10.1
27 keratoacanthoma 10.1
28 histiocytosis 10.1
29 papular xanthoma 10.1
30 progressive nodular histiocytosis 10.1
31 malignant tumor of penis 10.1
32 whim syndrome 10.1 TMC8 TMC6
33 glomeruloid hemangioma 10.1 PECAM1 FLT1
34 skin hemangioma 10.1 GLA ACE
35 bartonellosis 10.0 PECAM1 ACE
36 benign mesothelioma 10.0 WT1 PECAM1
37 intussusception 10.0 PECAM1 FLT1
38 acute apical periodontitis 10.0 NKRF ACE
39 capillary hemangioma 10.0 PROX1 PECAM1 FLT1
40 capillary disease 10.0 PROX1 PECAM1 FLT1
41 hypertensive encephalopathy 10.0 FLT1 ACE
42 angiosarcoma 10.0 PROX1 PECAM1 FLT1
43 middle ear carcinoma 9.9 WT1 MMP9
44 acute mountain sickness 9.9 FLT1 ACE
45 decubitus ulcer 9.9 PECAM1 MMP9
46 membranous nephropathy 9.8 WT1 PECAM1 ACE
47 macular retinal edema 9.8 FLT1 ACE
48 gastroesophageal junction adenocarcinoma 9.8 MMP9 FLT1
49 uveal disease 9.8 WT1 GNAQ ACE
50 heart aneurysm 9.8 MMP9 ACE

Graphical network of the top 20 diseases related to Angiokeratoma of Fordyce:



Diseases related to Angiokeratoma of Fordyce

Symptoms & Phenotypes for Angiokeratoma of Fordyce

MGI Mouse Phenotypes related to Angiokeratoma of Fordyce:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 ACE FLT1 GLA GNAQ INMT MMP9
2 cardiovascular system MP:0005385 9.92 ACE FLT1 GLA GNAQ MMP9 PECAM1
3 immune system MP:0005387 9.81 ACE FLT1 GLA GNAQ INMT MMP9
4 muscle MP:0005369 9.5 FLT1 GLA GNAQ MMP9 PECAM1 PROX1
5 renal/urinary system MP:0005367 9.1 ACE GLA GNAQ MMP9 PECAM1 WT1

Drugs & Therapeutics for Angiokeratoma of Fordyce

Search Clinical Trials , NIH Clinical Center for Angiokeratoma of Fordyce

Genetic Tests for Angiokeratoma of Fordyce

Anatomical Context for Angiokeratoma of Fordyce

Publications for Angiokeratoma of Fordyce

Articles related to Angiokeratoma of Fordyce:

(show all 36)
# Title Authors PMID Year
1
Visual Dermatology: Angiokeratoma of Fordyce. 61
32208014 2020
2
A case report of adult-onset multiple angiokeratomas with zosteriform distribution. 61
30677813 2018
3
Recurrent, nodular lesions over the vulva: A diagnostic challenge. 61
30623184 2018
4
Genital angiokeratomas of Fordyce 595-nm variable-pulse pulsed dye laser treatment. 61
28665237 2017
5
Sodium Tetradecyl Sulfate: A Review of Clinical Uses. 61
28430735 2017
6
Rare Giant Angiokeratoma of the Vulva: A Case Report. 61
28418344 2017
7
Pulsed dye laser versus long pulsed Nd:YAG laser in the treatment of angiokeratoma of Fordyce: A randomized, comparative, observer-blinded study. 61
26371766 2016
8
Angiokeratoma of Fordyce response to long pulsed Nd:YAG laser treatment. 61
26531316 2016
9
Multiple giant angiokeratoma of Fordyce on the shaft of the penis masquerading as keratoacanthoma. 61
26312700 2015
10
A giant angiokeratoma of Fordyce: an uncommon cause of acute scrotum. 61
24051154 2013
11
Giant angiokeratoma of Fordyce over the vulva in a middle-aged woman: case report and review of literature. 61
23723496 2013
12
Unilateral angiokeratoma of Fordyce. 61
22917529 2013
13
[Therapy for Angiokeratoma of Fordyce with the 940-nm Diode Laser]. 61
22002010 2012
14
Augmented diagnostic capability using videodermatoscopy on selected infectious and non-infectious penile growths. 61
22097996 2011
15
Late-onset Fabry disease associated with angiokeratoma of Fordyce and multiple cherry angiomas. 61
21457158 2011
16
Lewandowsky and lutz dysplasia: report of two cases in a family. 61
21716545 2011
17
Angiokeratoma of Fordyce treated with 0.5% ethanolamine oleate or 0.25% sodium tetradecyl sulfate. 61
21053421 2010
18
Report of two angiokeratoma of Fordyce cases treated with a 1064 nm long-pulsed Nd:YAG laser. 61
19439000 2009
19
Treatment of angiokeratoma of Fordyce with long-pulse neodymium-doped yttrium aluminium garnet laser. 61
19076189 2009
20
Angiokeratoma of Fordyce simulating recurrent penile cancer. 61
17382178 2007
21
Rare case of recurrent angiokeratoma of Fordyce on penile shaft. 61
17070385 2006
22
[Intergluteal angiokeratoma circumscriptum. Report of one case]. 61
17224109 2006
23
Treatment of angiokeratoma of Fordyce with pulsed dye laser. 61
16970695 2006
24
Naevus lipomatosus cutaneous superficialis of Hoffmann-Zurhelle with angiokeratoma of Fordyce. 61
16586009 2006
25
Unilateral angiokeratoma of Fordyce. 61
17642671 2004
26
Papular xanthoma associated with angiokeratoma of Fordyce: considerations on the nosography of this rare non-Langerhans cell histiocytoxanthomatosis. 61
12592087 2003
27
An exceptional localization of angiokeratoma of fordyce on the glans penis. 61
12218243 2002
28
Angiokeratoma of Fordyce as a cause of red scrotum. 61
11829180 2002
29
Angiokeratoma of fordyce on unusual site. 61
20921672 1999
30
Congenital angiokeratoma of Fordyce. 61
9553928 1998
31
Argon laser treatment of cutaneous multiple angiokeratomas. 61
7894939 1995
32
Angiokeratoma of Fordyce: a cause of scrotal bleeding. 61
8012789 1994
33
Angiokeratoma of Fordyce. 61
2407964 1990
34
[Angiokeratoma of Fordyce]. 61
2353050 1990
35
Angiokeratoma of Fordyce: successful treatment with the argon laser. 61
6505104 1984
36
Hemangiomas of the scrotum (angiokeratoma of Fordyce?). 61
20262881 1947

Variations for Angiokeratoma of Fordyce

Expression for Angiokeratoma of Fordyce

Search GEO for disease gene expression data for Angiokeratoma of Fordyce.

Pathways for Angiokeratoma of Fordyce

Pathways related to Angiokeratoma of Fordyce according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 WT1 MMP9 FLT1
2 10.87 PROX1 PECAM1 MMP9 FLT1
3 10.83 MMP9 ACE
4 10.54 MMP9 FLT1
5 10.32 MMP9 ACE

GO Terms for Angiokeratoma of Fordyce

Cellular components related to Angiokeratoma of Fordyce according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.17 TMC8 TMC6 PECAM1 MMP9 GNAQ GLA
2 nuclear membrane GO:0031965 9.13 TMC8 TMC6 GNAQ

Biological processes related to Angiokeratoma of Fordyce according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.46 TMC6 PECAM1 MMP9 GLA
2 kidney development GO:0001822 9.13 WT1 PROX1 ACE
3 positive regulation of heart growth GO:0060421 8.62 WT1 PROX1

Molecular functions related to Angiokeratoma of Fordyce according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mechanosensitive ion channel activity GO:0008381 8.62 TMC8 TMC6

Sources for Angiokeratoma of Fordyce

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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