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MCID: ANG018
MIFTS: 50

Angiomyolipoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Angiomyolipoma

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MalaCards integrated aliases for Angiomyolipoma:

Name: Angiomyolipoma 12 56 45 15 74
Angiomyolipoma of Kidney 74

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3314
MeSH 45 D018207
NCIt 51 C3734
SNOMED-CT 69 19929002
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Summaries for Angiomyolipoma

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Disease Ontology : 12 A cell type benign neoplasm that is primarily located in the kidneys but may be found in the lungs, liver or other organs and is derived from perivascular epithelioid cells.

MalaCards based summary : Angiomyolipoma, also known as angiomyolipoma of kidney, is related to kidney angiomyolipoma and hepatic angiomyolipoma. An important gene associated with Angiomyolipoma is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and breast, and related phenotypes are cellular and behavior/neurological

Wikipedia : 77 Angiomyolipomas are the most common benign tumour of the kidney. Although regarded as benign,... more...

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Related Diseases for Angiomyolipoma

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Diseases related to Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 kidney angiomyolipoma 34.1 MTOR TSC1 TSC2
2 hepatic angiomyolipoma 33.4 KIT MTOR TSC2
3 tuberous sclerosis 2 32.6 MTOR TSC1 TSC2
4 tuberous sclerosis 1 32.2 CCL26 MTOR TSC1 TSC2
5 lymphangioleiomyomatosis 31.5 DES ESR1 MTOR PGR TSC1 TSC2
6 tuberous sclerosis 31.0 CCL26 MTOR TSC1 TSC2 VIM
7 congenital heart defects, hamartomas of tongue, and polysyndactyly 30.6 CCL26 TSC1 TSC2
8 subependymal giant cell astrocytoma 30.5 MTOR TSC1 TSC2
9 lymphangiectasis 30.2 ACTC1 VIM
10 renal cell carcinoma, nonpapillary 30.0 KIT MITF MTOR TSC1 TSC2 VIM
11 autosomal dominant polycystic kidney disease 29.9 MTOR TSC1 TSC2
12 renal cell carcinoma, papillary, 1 29.8 KIT MITF MTOR
13 neurilemmoma 29.7 DES KIT VIM
14 cavernous hemangioma 29.7 DES KIT VIM
15 sarcoma, synovial 29.5 DES KIT VIM
16 gastrointestinal stromal tumor 29.2 ACTC1 DES KIT VIM
17 cystic nephroma 29.2 DES KIT PGR VIM
18 perivascular epithelioid cell tumor 29.1 ACTC1 DES KIT PGR TSC2 VIM
19 childhood kidney angiomyolipoma 12.2
20 epithelioid type angiomyolipoma 12.1
21 multiple endocrine neoplasia, type i 11.1
22 polycystic kidney disease, infantile severe, with tuberous sclerosis 11.1
23 hepatocellular carcinoma 10.5
24 corneal dystrophy, fleck 10.5 TSC1 TSC2
25 ischemic fasciitis 10.4 ACTC1 DES
26 dedifferentiated liposarcoma 10.4 ACTC1 DES
27 granular cell tumor 10.4 DES VIM
28 mesenchymal chondrosarcoma 10.4 DES VIM
29 extraskeletal ewing sarcoma 10.4 DES VIM
30 adult hepatocellular carcinoma 10.4 TSC1 TSC2
31 dendritic cell tumor 10.4 ACTC1 VIM
32 kidney benign neoplasm 10.4 MTOR TSC2
33 plasmablastic lymphoma 10.4 DES MTOR
34 fibroblastic rheumatism 10.4 ACTC1 DES
35 infantile digital fibromatosis 10.4 DES VIM
36 oncocytoma 10.4
37 cutaneous leiomyosarcoma 10.3 ACTC1 DES
38 botryoid rhabdomyosarcoma 10.3 ACTC1 DES
39 primitive neuroectodermal tumor of the cervix uteri 10.3 DES VIM
40 chickenpox 10.3 ACTC1 PGR
41 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
42 glomangioma 10.3 ACTC1 DES
43 liposarcoma 10.3
44 sertoli cell tumor 10.3 PGR VIM
45 clear cell renal cell carcinoma 10.3
46 biphasic synovial sarcoma 10.3 DES VIM
47 non-langerhans-cell histiocytosis 10.3 ACTC1 DES
48 adenofibroma 10.3 ACTC1 VIM
49 calcifying aponeurotic fibroma 10.3 ACTC1 PGR
50 childhood kidney cell carcinoma 10.3 MITF TSC2

Graphical network of the top 20 diseases related to Angiomyolipoma:



Diseases related to Angiomyolipoma
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Symptoms & Phenotypes for Angiomyolipoma

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MGI Mouse Phenotypes related to Angiomyolipoma:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ACTC1 DES ESR1 KIT MITF MTOR
2 behavior/neurological MP:0005386 10.27 DES ESR1 KIT MITF MTOR PGR
3 cardiovascular system MP:0005385 10.26 ACTC1 DES ESR1 KIT MTOR PGR
4 homeostasis/metabolism MP:0005376 10.25 ACTC1 DES ESR1 KIT MITF MTOR
5 mortality/aging MP:0010768 10.2 ACTC1 DES ESR1 KIT MITF MTOR
6 embryo MP:0005380 10.19 ESR1 KIT MITF MTOR PGR TSC1
7 endocrine/exocrine gland MP:0005379 10.13 ESR1 KIT MITF MTOR PGR TSC1
8 integument MP:0010771 10.04 ESR1 KIT MITF PGR TSC1 TSC2
9 muscle MP:0005369 10.03 ACTC1 DES ESR1 KIT MTOR PGR
10 nervous system MP:0003631 9.97 ESR1 KIT MITF MTOR TSC1 TSC2
11 limbs/digits/tail MP:0005371 9.88 ESR1 KIT MITF PGR TYR
12 neoplasm MP:0002006 9.88 ESR1 KIT PGR TSC1 TSC2 TYR
13 normal MP:0002873 9.86 ACTC1 ESR1 KIT MITF MTOR PGR
14 no phenotypic analysis MP:0003012 9.8 ESR1 KIT MITF MTOR PGR TYR
15 renal/urinary system MP:0005367 9.63 ESR1 KIT MTOR TSC1 TSC2 TYR
16 reproductive system MP:0005389 9.56 ESR1 KIT MITF PGR TSC1 TSC2
17 skeleton MP:0005390 9.17 ESR1 KIT MITF MTOR PGR TSC1
Sources

Drugs & Therapeutics for Angiomyolipoma

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Drugs for Angiomyolipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 5284616 6436030
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 70789204 6442177
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
6 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antimalarials Phase 4
12 Antiparasitic Agents Phase 4
13 Antiprotozoal Agents Phase 4
14
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
15
Propranolol Approved, Investigational Phase 2 525-66-6 4946
16
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
17
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
18
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
19
Saracatinib Investigational Phase 2 379231-04-6
20 Estrogen Receptor Antagonists Phase 2
21 Hormone Antagonists Phase 2
22 Steroid Synthesis Inhibitors Phase 2
23 Estrogens Phase 2
24 Hormones Phase 2
25 Aromatase Inhibitors Phase 2
26 Estrogen Antagonists Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
28 Antihypertensive Agents Phase 2
29 Adrenergic Agents Phase 2
30 Neurotransmitter Agents Phase 2
31 Vasodilator Agents Phase 2
32 Anti-Arrhythmia Agents Phase 2
33 Adrenergic Antagonists Phase 2
34 Angiogenesis Inhibitors Phase 2
35 Adrenergic beta-Antagonists Phase 2
36 Gastrointestinal Agents Phase 2
37 Antineoplastic Agents, Hormonal Phase 2
38 Liver Extracts Phase 2
39 Anti-Inflammatory Agents, Non-Steroidal Phase 2
40 Analgesics, Non-Narcotic Phase 2
41 Antirheumatic Agents Phase 2
42 Cola Phase 2
43 Cyclooxygenase Inhibitors Phase 2
44 Anti-Inflammatory Agents Phase 2
45 Analgesics Phase 2
46 Peripheral Nervous System Agents Phase 2
47 Cyclooxygenase 2 Inhibitors Phase 2
48
Ceritinib Approved Phase 1 1032900-25-6
49 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Rapamycin In Angiomyolipomas In Patients With Tuberous Sclerosis Completed NCT01217125 Phase 4 Sirolimus
2 Doxycycline In Lymphangioleiomyomatosis (LAM) Completed NCT00989742 Phase 4 Doxycycline;Placebo
3 Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex. Recruiting NCT03525834 Phase 4 everolimus
4 Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00790400 Phase 3 Everolimus (RAD001);Everolimus Placebo
5 Sirolimus in Treating Patients With Angiomyolipoma of the Kidney Unknown status NCT00126672 Phase 2 sirolimus
6 Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM Unknown status NCT00490789 Phase 2 sirolimus
7 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2 everolimus and letrozole
8 Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers Completed NCT02104011 Phase 2 Propranolol
9 RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM Completed NCT00457964 Phase 1, Phase 2 RAD001
10 Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00792766 Phase 1, Phase 2 everolimus (RAD001)
11 Rapamycin Therapy for Patients With Tuberous Sclerosis Complex and Sporadic LAM Completed NCT00457808 Phase 2 Rapamycin, sirolimus
12 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
13 A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD Recruiting NCT02451696 Phase 2 Everolimus
14 Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis Recruiting NCT02737202 Phase 2 saracatinib
15 COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC Active, not recruiting NCT02484664 Phase 2 Celecoxib
16 Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus Terminated NCT02539459 Phase 2 Everolimus
17 A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa Withdrawn NCT01690871 Phase 2 BEZ235
18 Phase I/Ib Dose Escalation & Biomarker Study of Ceritinib (LDK378) + Everolimus for Locally Advanced or Metastatic Solid Tumors With an Expansion in Non-Small Cell Lung Cancer (NSCLC) Characterized by Abnormalities in Anaplastic Lymphoma Kinase (ALK) Expression Recruiting NCT02321501 Phase 1 Ceritinib (LDK378);Ceritinib (LDK378) 750 mg;Everolimus
19 Tuberous Sclerosis Complex Natural History Study: Renal Manifestations Completed NCT00598455
20 Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma Recruiting NCT02325505
21 Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France Recruiting NCT02887781
22 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Recruiting NCT03477149 Not Applicable
23 PEComas: Natural History and Prognostic Factors Recruiting NCT03916575
24 Genetic Heterogeneity and Genotype-phenotype Correlation of Children and Adults With Tuberous Sclerosis Complex (TuScCom) Recruiting NCT02654340
25 A National Registry on Chinese Patients With Lymphangioleiomyomatosis Recruiting NCT03193892

Search NIH Clinical Center for Angiomyolipoma

Cochrane evidence based reviews: angiomyolipoma

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Genetic Tests for Angiomyolipoma

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Anatomical Context for Angiomyolipoma

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MalaCards organs/tissues related to Angiomyolipoma:

42
Kidney, Liver, Breast, Lung, Lymph Node, Smooth Muscle, Colon
Sources

Publications for Angiomyolipoma

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Articles related to Angiomyolipoma:

(show top 50) (show all 1587)
# Title Authors Year
1
Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness. ( 29697822 )
2019
2
The differential enhancement pattern of contrast enhanced ultrasound and magnetic resonance imaging characteristics in hepatic angiomyolipoma: 7 case reports. ( 30010112 )
2019
3
Whole-Tumor Quantitative Apparent Diffusion Coefficient Histogram and Texture Analysis to Differentiation of Minimal Fat Angiomyolipoma from Clear Cell Renal Cell Carcinoma. ( 30087067 )
2019
4
Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review. ( 30124505 )
2019
5
Correction: miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma. ( 30337693 )
2019
6
Continuous low-dose everolimus shrinkage tuberous sclerosis complex-associated renal angiomyolipoma: a 48-month follow-up study. ( 30455224 )
2019
7
Adrenal angiomyolipoma: a rare localization. ( 30457130 )
2019
8
Renal Angiomyolipoma Based on New Classification: How to Differentiate It From Renal Cell Carcinoma. ( 30620673 )
2019
9
Malignancy of renal angiomyolipoma from tuberous sclerosis complex with TSC2 mutation. ( 30628968 )
2019
10
Wunderlich syndrome, spontaneous ruptured renal angiomyolipoma & tuberous sclerosis. ( 30629244 )
2019
11
Late local, peritoneal and systemic recurrence of renal angiomyolipoma: A case report. ( 30655976 )
2019
12
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. ( 30675208 )
2019
13
Hepatic angiomyolipoma with early drainage veins into the hepatic and portal vein. ( 30762212 )
2019
14
Renal Epithelioid Angiomyolipoma Undergoing Aggressive Clinical Outcome: The MDM2 Expression in Tumor Cells of Two Cases. ( 30799331 )
2019
15
Differentiation of renal angiomyolipoma without visible fat from renal cell carcinoma by machine learning based on whole-tumor computed tomography texture features. ( 30799634 )
2019
16
New radiologic classification of renal angiomyolipoma: frequently asked questions. ( 30825810 )
2019
17
Clinicopathologic analysis of renal epithelioid angiomyolipoma: Consecutively excised 23 cases. ( 30844148 )
2019
18
Embolization of Ruptured Renal Angiomyolipoma in Puerpera. ( 30868552 )
2019
19
Angiomyolipoma of the Adrenal Glands. ( 30878377 )
2019
20
The value of quantitative CT texture analysis in differentiation of angiomyolipoma without visible fat from clear cell renal cell carcinoma on four-phase contrast-enhanced CT images. ( 31010583 )
2019
21
Percutaneous nephrolithotomy of a staghorn calculus in a patient with renal angiomyolipoma. ( 31040616 )
2019
22
Use of Iodine Concentration in the Lipid-Poor Portion of the Renal Mass for Differentiation of Angiomyolipoma from Renal Cell Carcinoma. ( 31070481 )
2019
23
Recurrent, Giant Renal Angiomyolipoma Treated with Selective Arterial Embolization: A Case Report. ( 29275410 )
2019
24
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. ( 29392818 )
2018
25
Hepatic angiomyolipoma detected using computed tomography. ( 29392859 )
2018
26
Superselective Transcatheter Arterial Embolization for Large Unruptured Renal Angiomyolipoma in Lymphangioleiomyomatosis. ( 29398412 )
2018
27
Spontaneous reduction of native kidney size involving angiomyolipoma lesions in a kidney transplant recipient with tuberous sclerosis complex. ( 29417638 )
2018
28
Expression of MDM2 and p16 in angiomyolipoma. ( 29432785 )
2018
29
Deep feature classification of angiomyolipoma without visible fat and renal cell carcinoma in abdominal contrast-enhanced CT images with texture image patches and hand-crafted feature concatenation. ( 29474742 )
2018
30
Inflammatory angiomyolipoma of the liver: a diagnostic pitfall. ( 29496202 )
2018
31
Angiomyolipoma: A link between stemness and tumorigenesis in the kidney. ( 29503451 )
2018
32
Imaging appearance of renal epithelioid angiomyolipoma: A case report and literature review. ( 29505538 )
2018
33
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. ( 29512829 )
2018
34
Renal epithelioid angiomyolipoma: magnetic resonance imaging characteristics. ( 29525877 )
2018
35
miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma. ( 29540858 )
2018
36
Effect of everolimus on skin lesions in patients treated for subependymal giant cell astrocytoma and renal angiomyolipoma: final 4-year results from the randomized EXIST-1 and EXIST-2 studies. ( 29569806 )
2018
37
Intensity ratio curve analysis of small renal masses on T2-weighted magnetic resonance imaging: Differentiation of fat-poor angiomyolipoma from renal cell carcinoma. ( 29577440 )
2018
38
Hepatic Epithelioid Angiomyolipoma and 18F-FDG PET/CT. ( 29578870 )
2018
39
Assessing the outcomes of everolimus on renal angiomyolipoma associated with tuberous sclerosis complex in China: a two years trial. ( 29587809 )
2018
40
Editorial Comment to Intensity ratio curve analysis of small renal masses on T2-weighted magnetic resonance imaging: Differentiation of fat-poor angiomyolipoma from renal cell carcinoma. ( 29651812 )
2018
41
Surveillance imaging for sporadic renal angiomyolipoma less than 40 mm: lessons learnt and recommendations from the experience of a large district general hospital. ( 29658337 )
2018
42
An update on recent developments in rupture of renal angiomyolipoma. ( 29668633 )
2018
43
Angiomyolipoma of the Kidneys: Current Perspectives and Challenges in Diagnostic Imaging and Image-Guided Therapy. ( 29685402 )
2018
44
Bilateral Giant Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Complex: A Case Report. ( 29686177 )
2018
45
Pulmonary lymphangioleiomyomatosis associated with aggressive renal angiomyolipoma. ( 29686563 )
2018
46
Consequences of delay in screening, monitoring, and treatment of angiomyolipoma and tuberous sclerosis: A case report
. ( 29701176 )
2018
47
A rare case of renal angiomyolipoma involved both inferior vena cava and pulmonary arteries. ( 29707365 )
2018
48
Retroperitoneal laparoscopic nephron sparing surgery for large renal angiomyolipoma: Our technique and experience. A case series of 41 patients. ( 29723675 )
2018
49
Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation. ( 29764404 )
2018
50
Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dubé: chaperones in pathogenesis. ( 29774133 )
2018
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Variations for Angiomyolipoma

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Expression for Angiomyolipoma

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Search GEO for disease gene expression data for Angiomyolipoma.
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Pathways for Angiomyolipoma

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Pathways related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 65
Show member pathways
 13.55 CCL26 DES ESR1 KIT MTOR TSC1
2
Pathways in cancer 38
12.62 ESR1 KIT MITF MTOR
3
Gastric cancer 38
Show member pathways
 12.53 ESR1 KIT MTOR PGR
4
Glioma 38
Show member pathways
 12.25 ESR1 MITF MTOR TSC1 TSC2
5
Phospholipase D signaling pathway 38
Show member pathways
 12.1 KIT MTOR TSC1 TSC2
6
Translational Control 4
12.07 MTOR TSC1 TSC2
7
AMPK Enzyme Complex Pathway 65
Show member pathways
 12 MTOR TSC1 TSC2
8
Cellular senescence (KEGG) 38
11.96 MTOR TSC1 TSC2
9
AKT Signaling Pathway 68
11.94 MTOR TSC1 TSC2
10
Longevity regulating pathway 38
Show member pathways
 11.91 MTOR TSC1 TSC2
11
Autophagy Pathway 66
Show member pathways
 11.9 MTOR TSC1 TSC2
12
Autophagy - animal 38
11.81 MTOR TSC1 TSC2
13
Thyroid hormone signaling pathway 38
11.75 ESR1 MTOR TSC2
14
Glioblastoma Multiforme 65
11.72 MTOR TSC1 TSC2
15
Integrated Breast Cancer Pathway 1
11.64 ESR1 MTOR TSC1 TSC2
16
TP53 Regulates Metabolic Genes 67
11.56 MTOR TSC1 TSC2
17
Striated Muscle Contraction 1 67
11.47 ACTC1 DES VIM
18
mTOR signaling pathway (Pathway Interaction Database) 1
11.33 MTOR TSC1 TSC2
19
Wnt Signaling Pathway Netpath 1
11.22 MTOR TSC1 TSC2
20
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.09 MTOR TSC2
21
Follicle Stimulating Hormone (FSH) signaling pathway 1
11.02 MTOR TSC2
22
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 1
10.79 MTOR TSC1
23
BDNF-TrkB Signaling 1
10.66 MTOR TSC1 TSC2
24
LKB1 signaling events 1
10.55 ESR1 MTOR TSC1 TSC2
Sources

GO Terms for Angiomyolipoma

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Cellular components related to Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.81 ACTC1 DES ESR1 MTOR PGR TSC1
2 cytoplasm GO:0005737 9.65 ACTC1 DES ESR1 KIT MTOR PGR
3 TSC1-TSC2 complex GO:0033596 8.62 TSC1 TSC2

Biological processes related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.67 ESR1 KIT MTOR
2 positive regulation of gene expression GO:0010628 9.55 ACTC1 KIT MITF MTOR VIM
3 regulation of protein kinase activity GO:0045859 9.52 MTOR TSC1
4 stem cell differentiation GO:0048863 9.51 ESR1 KIT
5 melanocyte differentiation GO:0030318 9.48 KIT MITF
6 intermediate filament organization GO:0045109 9.46 DES VIM
7 regulation of osteoclast differentiation GO:0045670 9.43 MITF MTOR
8 negative regulation of macroautophagy GO:0016242 9.4 MTOR TSC1
9 positive regulation of phospholipase C activity GO:0010863 9.37 ESR1 KIT
10 anoikis GO:0043276 9.32 MTOR TSC2
11 negative regulation of cell size GO:0045792 9.26 MTOR TSC1
12 pigmentation GO:0043473 9.13 KIT MITF TYR
13 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 DES ESR1 MTOR PGR VIM
2 steroid binding GO:0005496 8.96 ESR1 PGR
Sources

Sources for Angiomyolipoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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