MCID: ANG018
MIFTS: 50

Angiomyolipoma

Categories: Cancer diseases

Aliases & Classifications for Angiomyolipoma

MalaCards integrated aliases for Angiomyolipoma:

Name: Angiomyolipoma 12 55 44 15 73
Angiomyolipoma of Kidney 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3314
MeSH 44 D018207
NCIt 50 C3734
SNOMED-CT 68 19929002

Summaries for Angiomyolipoma

Disease Ontology : 12 A cell type benign neoplasm that is primarily located in the kidneys but may be found in the lungs, liver or other organs consisting of perivascular epithelioid (pericyte and macrophage) cells.

MalaCards based summary : Angiomyolipoma, also known as angiomyolipoma of kidney, is related to kidney angiomyolipoma and hepatic angiomyolipoma. An important gene associated with Angiomyolipoma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Afinitor and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and lung, and related phenotypes are cellular and behavior/neurological

Wikipedia : 76 Angiomyolipomas are the most common benign tumour of the kidney. Although regarded as benign,... more...

Related Diseases for Angiomyolipoma

Diseases related to Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 kidney angiomyolipoma 33.8 MTOR TSC1 TSC2
2 hepatic angiomyolipoma 33.4 KIT MTOR TSC2
3 tuberous sclerosis 1 32.2 CCL26 MTOR TSC1 TSC2
4 tuberous sclerosis 2 31.9 MTOR TSC1 TSC2
5 lymphangioleiomyomatosis 31.7 DES ESR1 MTOR PGR TSC1 TSC2
6 tuberous sclerosis 31.2 CCL26 MTOR TSC1 TSC2
7 renal cell carcinoma, nonpapillary 30.5 KIT MITF MTOR TSC1 TSC2
8 subependymal giant cell astrocytoma 30.3 MTOR TSC1 TSC2
9 horseshoe kidney 30.1 ACTC1 TSC2
10 renal cell carcinoma, papillary, 1 30.0 KIT MITF MTOR
11 autosomal dominant polycystic kidney disease 29.7 MTOR TSC1 TSC2
12 perivascular epithelioid cell tumor 29.6 ACTC1 DES KIT PGR TSC2
13 gastrointestinal stromal tumor 29.5 ACTC1 DES KIT
14 cystic nephroma 29.5 DES KIT PGR
15 childhood kidney angiomyolipoma 12.1
16 epithelioid type angiomyolipoma 12.1
17 multiple endocrine neoplasia, type i 11.1
18 polycystic kidney disease, infantile severe, with tuberous sclerosis 11.1
19 hepatocellular carcinoma 10.4
20 oncocytoma 10.3
21 clear cell renal cell carcinoma 10.3
22 fibroblastic rheumatism 10.3 ACTC1 DES
23 angiolipoma 10.2 ACTC1 DES
24 cutaneous leiomyosarcoma 10.2 ACTC1 DES
25 botryoid rhabdomyosarcoma 10.2 ACTC1 DES
26 spindle cell lipoma 10.2 ACTC1 DES
27 glomangioma 10.2 ACTC1 DES
28 parachordoma 10.2 ACTC1 DES
29 ossifying fibromyxoid tumor 10.2 ACTC1 DES
30 adult hepatocellular carcinoma 10.2 TSC1 TSC2
31 liposarcoma 10.2
32 epithelioid leiomyosarcoma 10.2 ACTC1 DES
33 non-langerhans-cell histiocytosis 10.2 ACTC1 DES
34 cutaneous fibrous histiocytoma 10.2 ACTC1 DES
35 congenital fibrosarcoma 10.2 ACTC1 DES
36 ischemic fasciitis 10.2 ACTC1 DES
37 reticulum cell sarcoma 10.2 ACTC1 DES
38 lissencephaly with cerebellar hypoplasia 10.2 TSC1 TSC2
39 pseudosarcomatous fibromatosis 10.2 ACTC1 DES
40 dedifferentiated liposarcoma 10.2 ACTC1 DES
41 lymphangiomatosis 10.2 DES PGR
42 glomus tumor 10.2 ACTC1 DES
43 calcifying aponeurotic fibroma 10.2 ACTC1 PGR
44 spindle cell sarcoma 10.2 ACTC1 DES
45 epulis 10.2 DES PGR
46 bizarre leiomyoma 10.2 ACTC1 PGR
47 myxoid leiomyosarcoma 10.2 ACTC1 PGR
48 kidney benign neoplasm 10.2 MTOR TSC2
49 syringoma 10.2 DES ESR1
50 plasmablastic lymphoma 10.2 DES MTOR

Graphical network of the top 20 diseases related to Angiomyolipoma:



Diseases related to Angiomyolipoma

Symptoms & Phenotypes for Angiomyolipoma

MGI Mouse Phenotypes related to Angiomyolipoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 ACTC1 DES ESR1 KIT MITF MTOR
2 behavior/neurological MP:0005386 10.22 DES ESR1 KIT MITF MTOR PGR
3 cardiovascular system MP:0005385 10.21 ACTC1 DES ESR1 KIT MTOR PGR
4 homeostasis/metabolism MP:0005376 10.19 ACTC1 DES ESR1 KIT MITF MTOR
5 embryo MP:0005380 10.14 ESR1 KIT MITF MTOR PGR TSC1
6 endocrine/exocrine gland MP:0005379 10.13 ESR1 KIT MITF MTOR PGR TSC1
7 mortality/aging MP:0010768 10.13 ACTC1 DES ESR1 KIT MITF MTOR
8 growth/size/body region MP:0005378 10.11 ACTC1 ESR1 KIT MITF MTOR TSC1
9 integument MP:0010771 10.02 ESR1 KIT MITF PGR TSC1 TSC2
10 muscle MP:0005369 9.95 ACTC1 DES ESR1 KIT MTOR PGR
11 normal MP:0002873 9.86 ACTC1 ESR1 KIT MITF MTOR PGR
12 limbs/digits/tail MP:0005371 9.85 ESR1 KIT MITF PGR TYR
13 neoplasm MP:0002006 9.85 ESR1 KIT PGR TSC1 TSC2 TYR
14 no phenotypic analysis MP:0003012 9.8 ESR1 KIT MITF MTOR PGR TYR
15 renal/urinary system MP:0005367 9.63 ESR1 KIT MTOR TSC1 TSC2 TYR
16 reproductive system MP:0005389 9.5 ESR1 KIT MITF PGR TSC1 TSC2
17 skeleton MP:0005390 9.17 ESR1 KIT MITF MTOR PGR TSC1

Drugs & Therapeutics for Angiomyolipoma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Afinitor 18 49 EVEROLIMUS Novartis March 2009

Drugs for Angiomyolipoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
2
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
4
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
5 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1
6 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antiparasitic Agents Phase 4
12 Antiprotozoal Agents Phase 4
13 Antimalarials Phase 4
14
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
15
Propranolol Approved, Investigational Phase 2 525-66-6 4946
16
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
17
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
18
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
19
Saracatinib Investigational Phase 2 379231-04-6
20 Aromatase Inhibitors Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
22 Estrogen Receptor Antagonists Phase 2
23 Steroid Synthesis Inhibitors Phase 2
24 Estrogen Antagonists Phase 2
25 Hormones Phase 2
26 Hormone Antagonists Phase 2
27 Estrogens Phase 2
28 Vasodilator Agents Phase 2
29 Anti-Arrhythmia Agents Phase 2
30 Antihypertensive Agents Phase 2
31 Angiogenesis Inhibitors Phase 2
32 Adrenergic Antagonists Phase 2
33 Adrenergic beta-Antagonists Phase 2
34 Neurotransmitter Agents Phase 2
35 Adrenergic Agents Phase 2
36 Antineoplastic Agents, Hormonal Phase 2
37 Gastrointestinal Agents Phase 2
38 Liver Extracts Phase 2
39 Analgesics Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2
41 Cyclooxygenase 2 Inhibitors Phase 2
42 Cola Phase 2
43 Peripheral Nervous System Agents Phase 2
44 Cyclooxygenase Inhibitors Phase 2
45 Antirheumatic Agents Phase 2
46 Analgesics, Non-Narcotic Phase 2
47 Anti-Inflammatory Agents Phase 2
48
Ceritinib Approved Phase 1 1032900-25-6
49 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Rapamycin In Angiomyolipomas In Patients With Tuberous Sclerosis Completed NCT01217125 Phase 4 Sirolimus
2 Doxycycline In Lymphangioleiomyomatosis (LAM) Completed NCT00989742 Phase 4 Doxycycline;Placebo
3 Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex. Recruiting NCT03525834 Phase 4 everolimus
4 Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00790400 Phase 3 Everolimus (RAD001);Everolimus Placebo
5 Sirolimus in Treating Patients With Angiomyolipoma of the Kidney Unknown status NCT00126672 Phase 2 sirolimus
6 Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM Unknown status NCT00490789 Phase 2 sirolimus
7 Single Arm Trial With Combination of Everolimus and Letrozole in Treatment of Platinum Resistant Relapse or Refractory or Persistent Ovarian Cancer/Endometrial Cancer Unknown status NCT02188550 Phase 2 everolimus and letrozole
8 Treatment of Renal Angiomyolipomas in Tuberous Sclerosis by Beta-blockers Completed NCT02104011 Phase 2 Propranolol
9 RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM Completed NCT00457964 Phase 1, Phase 2 RAD001
10 Long Term Follow Up for RAD001 Therapy of Angiomyolipomata in Patients With Tuberous Sclerosis (TSC) and Sporadic Lymphangioleiomyomatosis (LAM) Completed NCT00792766 Phase 1, Phase 2 everolimus (RAD001)
11 Rapamycin Therapy for Patients With Tuberous Sclerosis Complex and Sporadic LAM Completed NCT00457808 Phase 2 Rapamycin, sirolimus
12 Treatment With Octreotide in Patients With Lymphangioleiomyomatosis Completed NCT00005906 Phase 2 Octreotide
13 A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD Recruiting NCT02451696 Phase 2 Everolimus
14 Safety and Efficacy of Saracatinib In Subjects With Lymphangioleiomyomatosis Recruiting NCT02737202 Phase 2 saracatinib
15 COLA: A Pilot Clinical Trial of COX-2 Inhibition in LAM and TSC Active, not recruiting NCT02484664 Phase 2 Celecoxib
16 Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus Terminated NCT02539459 Phase 2 Everolimus
17 A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa Withdrawn NCT01690871 Phase 2 BEZ235
18 Phase I/Ib Dose Escalation & Biomarker Study of Ceritinib (LDK378) + Everolimus for Locally Advanced or Metastatic Solid Tumors With an Expansion in Non-Small Cell Lung Cancer (NSCLC) Characterized by Abnormalities in Anaplastic Lymphoma Kinase (ALK) Expression Recruiting NCT02321501 Phase 1 Ceritinib (LDK378);Ceritinib (LDK378) 750 mg;Everolimus
19 Tuberous Sclerosis Complex Natural History Study: Renal Manifestations Completed NCT00598455
20 Characterization of Patients With Tuberous Sclerosis Complex, Lymphangioleiomyomatosis and Angiomyolipoma Recruiting NCT02325505
21 Clinical Presentation and Renal Outcome of Patients With Tuberous Sclerosis Complex and/or Renal Angiomyolipoma in the Great West Region of France Recruiting NCT02887781
22 EASYX-1 : A Multicenter Study on Safety and Efficacy of Easyx Liquid Embolization Agent Used in Five Separate Indications Recruiting NCT03477149 Not Applicable
23 A National Registry on Chinese Patients With Lymphangioleiomyomatosis Recruiting NCT03193892

Search NIH Clinical Center for Angiomyolipoma

Cochrane evidence based reviews: angiomyolipoma

Genetic Tests for Angiomyolipoma

Anatomical Context for Angiomyolipoma

MalaCards organs/tissues related to Angiomyolipoma:

41
Kidney, Liver, Lung, Lymph Node, Smooth Muscle, Colon, Breast

Publications for Angiomyolipoma

Articles related to Angiomyolipoma:

(show top 50) (show all 1333)
# Title Authors Year
1
Huge retroperitoneal epithelioid angiomyolipoma: A case report. ( 29276686 )
2018
2
mTORC1 Inhibition Is an Effective Treatment for Sporadic Renal Angiomyolipoma. ( 29340326 )
2018
3
A rare case of giant renal angiomyolipoma in a woman with tuberous sclerosis. ( 29942788 )
2018
4
Angiomyolipoma of the Liver without a Fat Component, Mimicking a Hepatocellular Carcinoma. ( 29361814 )
2018
5
Massive hematuria at pregnancy caused by ruptured angiomyolipoma: A case report. ( 29254628 )
2018
6
Consequences of delay in screening, monitoring, and treatment of angiomyolipoma and tuberous sclerosis: A case reporta8c. ( 29701176 )
2018
7
Two in One: Epithelioid angiomyolipoma within a classic kidney angiomyolipoma - a case report. ( 29843640 )
2018
8
Sporadic renal angiomyolipoma in a patient with Birt-Hogg-DubAc: chaperones in pathogenesis. ( 29774133 )
2018
9
Hepatic angiomyolipoma detected using computed tomography. ( 29392859 )
2018
10
Hepatic epithelioid angiomyolipoma with renal metastasis: radiologic-pathologic correlation. ( 29955240 )
2018
11
Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness. ( 29697822 )
2018
12
Re: Diagnostic Performance of CT for Diagnosis of Fat-Poor Angiomyolipoma in Patients with Renal Masses: A Systematic Review and Meta-Analysis. ( 29783555 )
2018
13
A rare highly aggressive tumor of the kidney: The pure epithelioid angiomyolipoma. ( 29785369 )
2018
14
Effect of everolimus on skin lesions in patients treated for subependymal giant cell astrocytoma and renal angiomyolipoma: final 4-year results from the randomised EXIST-1 and EXIST-2 studies. ( 29569806 )
2018
15
Human renal angiomyolipoma cells of male and female origin can migrate and are influenced by microenvironmental factors. ( 29920561 )
2018
16
The effect of everolimus on renal angiomyolipoma in pediatric patients with tuberous sclerosis being treated for subependymal giant cell astrocytoma. ( 28993887 )
2018
17
Retroperitoneal laparoscopic nephron sparing surgery for large renal angiomyolipoma: Our technique and experience. A case series of 41 patients. ( 29723675 )
2018
18
Bilateral Giant Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Complex: A Case Report. ( 29686177 )
2018
19
Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation. ( 29764404 )
2018
20
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis. ( 29512829 )
2018
21
Spontaneous reduction of native kidney size involving angiomyolipoma lesions in a kidney transplant recipient with tuberous sclerosis complex. ( 29417638 )
2018
22
Extrarenal retroperitoneal angiomyolipoma with oncocytoma. ( 29343920 )
2018
23
Gemstone spectral imaging dual-energy computed tomography for differentiation of renal cell carcinoma and minimal-fat renal angiomyolipoma. ( 29970695 )
2018
24
Pulmonary lymphangioleiomyomatosis associated with aggressive renal angiomyolipoma. ( 29686563 )
2018
25
Expression of MDM2 and p16 in Angiomyolipoma. ( 29432785 )
2018
26
Aggressive Renal Angiomyolipoma in a Patient with Tuberous Sclerosis Resulting in Pulmonary Tumor Embolus and Pulmonary Infarction<sup/>. ( 29885779 )
2018
27
Giant Extrarenal Retroperitoneal Angiomyolipoma: A Rare Case of a Large Size Tumor. ( 29980448 )
2018
28
Angiomyolipoma of the Kidneys: Current Perspectives and Challenges in Diagnostic Imaging and Image-Guided Therapy. ( 29685402 )
2018
29
Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid Angiomyolipoma: series of 4 primary tumors and 2 metastases. ( 29885406 )
2018
30
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. ( 29392818 )
2018
31
Malignant renal epithelioid angiomyolipoma with TFE3 gene amplification mimicking renalA carcinoma. ( 29951351 )
2018
32
Factors associated with the number and size of renal angiomyolipomas in sporadic angiomyolipoma (sAML): a study of adult patients with sAML managed in a Dutch tertiary referral center. ( 29333579 )
2018
33
Superselective Transcatheter Arterial Embolization for Large Unruptured Renal Angiomyolipoma in Lymphangioleiomyomatosis. ( 29398412 )
2018
34
Morphologic analysis with computed tomography may help differentiate fat-poor angiomyolipoma from renal cell carcinoma: a retrospective study with 602 patients. ( 28677004 )
2018
35
Atypical Epithelioid Angiomyolipoma: A Rare Variant With Malignant Potential. ( 28993216 )
2018
36
Transarterial Embolization of a Ruptured Renal Angiomyolipoma. ( 29021483 )
2018
37
t(6;11) renal cell carcinoma: a study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa/epithelioid angiomyolipoma. ( 29052596 )
2018
38
Differentiation between papillary renal cell carcinoma and fat-poor angiomyolipoma: a preliminary study assessing detection of intratumoral hemorrhage with chemical shift MRI and T2*-weighted gradient echo. ( 29069911 )
2018
39
Epithelioid Angiomyolipoma of the Liver. ( 29110191 )
2018
40
Machine learning-based quantitative texture analysis of CT images of small renal masses: Differentiation of angiomyolipoma without visible fat from renal cell carcinoma. ( 29134348 )
2018
41
Giant Renal Angiomyolipoma Following Ovarian Stimulation Therapy. ( 29154983 )
2018
42
Chemical shift magnetic resonance imaging for distinguishing minimal-fat renal angiomyolipoma from renal cell carcinoma: a meta-analysis. ( 29178029 )
2018
43
Extrarenal Angiomyolipoma: differential diagnosis of retroperitoneal masses. ( 29211401 )
2018
44
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. ( 29241297 )
2018
45
Deep feature classification of angiomyolipoma without visible fat and renal cell carcinoma in abdominal contrast-enhanced CT images with texture image patches and hand-crafted feature concatenation. ( 29474742 )
2018
46
Inflammatory angiomyolipoma of the liver: a diagnostic pitfall. ( 29496202 )
2018
47
Angiomyolipoma: A link between stemness and tumorigenesis in the kidney. ( 29503451 )
2018
48
Imaging appearance of renal epithelioid angiomyolipoma: A case report and literature review. ( 29505538 )
2018
49
Renal epithelioid angiomyolipoma: magnetic resonance imaging characteristics. ( 29525877 )
2018
50
miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma. ( 29540858 )
2018

Variations for Angiomyolipoma

Expression for Angiomyolipoma

Search GEO for disease gene expression data for Angiomyolipoma.

Pathways for Angiomyolipoma

Pathways related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 CCL26 DES ESR1 KIT MTOR TSC1
2 12.6 ESR1 KIT MITF MTOR
3
Show member pathways
12.49 ESR1 KIT MTOR PGR
4
Show member pathways
12.33 ESR1 MITF MTOR TSC1 TSC2
5
Show member pathways
12.1 MTOR TSC1 TSC2
6
Show member pathways
12.09 KIT MTOR TSC1 TSC2
7 12.06 MTOR TSC1 TSC2
8
Show member pathways
11.98 MTOR TSC1 TSC2
9 11.94 MTOR TSC1 TSC2
10 11.92 MTOR TSC1 TSC2
11
Show member pathways
11.9 MTOR TSC1 TSC2
12
Show member pathways
11.89 MTOR TSC1 TSC2
13 11.78 MTOR TSC1 TSC2
14 11.72 ESR1 MTOR TSC2
15 11.68 MTOR TSC1 TSC2
16 11.64 ESR1 MTOR TSC1 TSC2
17 11.54 MTOR TSC1 TSC2
18 11.33 MTOR TSC1 TSC2
19 11.22 MTOR TSC1 TSC2
20 11.17 ESR1 MITF
21 11.09 MTOR TSC2
22 11.03 MTOR TSC2
23 10.77 MTOR TSC1
24 10.66 MTOR TSC1 TSC2
25 10.55 ESR1 MTOR TSC1 TSC2

GO Terms for Angiomyolipoma

Cellular components related to Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC1 TSC2

Biological processes related to Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 ACTC1 KIT MITF MTOR
2 transcription, DNA-templated GO:0006351 9.7 ESR1 MITF PGR
3 positive regulation of protein kinase B signaling GO:0051897 9.63 ESR1 KIT MTOR
4 negative regulation of TOR signaling GO:0032007 9.55 TSC1 TSC2
5 negative regulation of insulin receptor signaling pathway GO:0046627 9.54 TSC1 TSC2
6 positive regulation of macroautophagy GO:0016239 9.51 TSC1 TSC2
7 regulation of protein kinase activity GO:0045859 9.49 MTOR TSC1
8 stem cell differentiation GO:0048863 9.48 ESR1 KIT
9 melanocyte differentiation GO:0030318 9.43 KIT MITF
10 regulation of osteoclast differentiation GO:0045670 9.37 MITF MTOR
11 negative regulation of macroautophagy GO:0016242 9.32 MTOR TSC1
12 positive regulation of phospholipase C activity GO:0010863 9.26 ESR1 KIT
13 anoikis GO:0043276 9.16 MTOR TSC2
14 negative regulation of cell size GO:0045792 8.96 MTOR TSC1
15 pigmentation GO:0043473 8.8 KIT MITF TYR

Molecular functions related to Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....