MCID: ANG002
MIFTS: 46

Angiostrongyliasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Angiostrongyliasis

Summaries for Angiostrongyliasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.

MalaCards based summary : Angiostrongyliasis is related to eosinophilic gastroenteritis and cysticercosis. An important gene associated with Angiostrongyliasis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include brain, eye and skin, and related phenotypes are headache and hypereosinophilia

Wikipedia : 73 Angiostrongyliasis is an infection by a roundworm of the Angiostrongylus type. Symptoms may vary from... more...

Related Diseases for Angiostrongyliasis

Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 eosinophilic gastroenteritis 30.2 IL5 IL4 CCL11
2 cysticercosis 30.2 MT-CO1 IL5 IL4
3 toxocariasis 30.1 IL5 IL4 IL13
4 meningitis 30.1 MMP9 IL5 IL4 IL2 IL13
5 ascaris lumbricoides infection 30.1 IL5 IL13
6 cytokine deficiency 30.1 IL5 IL13
7 paragonimiasis 30.0 MT-CO1 IL5 IL13
8 hypereosinophilic syndrome 30.0 IL5 IL4 IL2 IL13 CCL24 CCL11
9 gastroenteritis 30.0 MMP9 IL5 IL4 CCL11
10 trichinosis 29.9 IL5 IL4 IL13 CCL11
11 schistosomiasis 29.9 IL5 IL4 IL2 IL13
12 enterobiasis 29.8 MT-CO1 IL4
13 eosinophilic meningitis 29.7 PLAU MMP9 IL5 IL4 IL2 IL13
14 leishmaniasis 29.4 IL5 IL4 IL2 IL13
15 strongyloidiasis 29.4 MT-CO1 IL5 IL4 IL13 CCL11
16 parasitic helminthiasis infectious disease 29.0 MT-CO1 IL5 IL4 IL2 IL13 CCL11
17 taeniasis 29.0 MT-CO1 IL5 IL4 IL2 IL13
18 intestinal schistosomiasis 29.0 MT-CO1 IL5 IL4 IL2 IL13
19 meningoencephalitis 10.4
20 corneal ulcer 10.3 MMP9 CCL11
21 patulous eustachian tube 10.3 IL5 CCL11
22 pemphigoid gestationis 10.3 IL5 CCL11
23 cefaclor allergy 10.3 IL5 IL13
24 cefuroxime allergy 10.3 IL5 IL13
25 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
26 ceftriaxone allergy 10.3 IL5 IL13
27 mansonelliasis 10.3 IL5 CCL24
28 respiratory syncytial virus infectious disease 10.3 IL5 IL13
29 loeffler syndrome 10.3 IL5 IL13
30 intratubular embryonal carcinoma 10.3 PLAU MMP9
31 orange allergy 10.2 IL5 IL13
32 perforated corneal ulcer 10.2 PLAU MMP9
33 acute asthma 10.2 IL5 IL4
34 vasomotor rhinitis 10.2 IL5 IL13
35 cow milk allergy 10.2 IL5 IL4
36 toxic oil syndrome 10.2 IL5 IL4
37 cough variant asthma 10.2 IL5 IL4
38 cardiomyopathy, familial hypertrophic, 20 10.2 IL5 IL13
39 neurodermatitis 10.2 IL4 IL13
40 chronic eosinophilic pneumonia 10.2 IL5 CCL11
41 gnathomiasis 10.2
42 gnathostoma infection 10.2
43 chromoblastomycosis 10.2 MMP9 IL4
44 endomyocardial fibrosis 10.2 IL5 IL4
45 drug allergy 10.2 IL5 IL13
46 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.2 IL4 IL2
47 dacryoadenitis 10.2 IL4 IL13
48 beta-lactam allergy 10.2 IL4 IL13
49 neuritis 10.2
50 optic neuritis 10.2

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to Angiostrongyliasis

Symptoms & Phenotypes for Angiostrongyliasis

Human phenotypes related to Angiostrongyliasis:

58 31 (show all 40)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
2 hypereosinophilia 58 31 hallmark (90%) Very frequent (99-80%) HP:0032061
3 csf pleocytosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0012229
4 diplopia 58 31 frequent (33%) Frequent (79-30%) HP:0000651
5 constipation 58 31 frequent (33%) Frequent (79-30%) HP:0002019
6 increased intracranial pressure 58 31 frequent (33%) Frequent (79-30%) HP:0002516
7 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
8 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
9 irritability 58 31 frequent (33%) Frequent (79-30%) HP:0000737
10 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
11 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
12 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
13 paresthesia 58 31 frequent (33%) Frequent (79-30%) HP:0003401
14 meningitis 58 31 frequent (33%) Frequent (79-30%) HP:0001287
15 brain imaging abnormality 58 31 frequent (33%) Frequent (79-30%) HP:0410263
16 excessive daytime somnolence 58 31 frequent (33%) Frequent (79-30%) HP:0001262
17 poor appetite 58 31 frequent (33%) Frequent (79-30%) HP:0004396
18 stiff neck 58 31 frequent (33%) Frequent (79-30%) HP:0025258
19 projectile vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002587
20 gastrointestinal eosinophilia 58 31 frequent (33%) Frequent (79-30%) HP:0032064
21 ventriculomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002119
22 pruritus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000989
23 distal muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0002460
24 blurred vision 58 31 occasional (7.5%) Occasional (29-5%) HP:0000622
25 increased circulating iga level 58 31 occasional (7.5%) Occasional (29-5%) HP:0003261
26 increased circulating igm level 58 31 occasional (7.5%) Occasional (29-5%) HP:0003496
27 neck pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0030833
28 cerebral edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0002181
29 increased circulating igg level 58 31 occasional (7.5%) Occasional (29-5%) HP:0003237
30 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
31 nuchal rigidity 58 31 occasional (7.5%) Occasional (29-5%) HP:0031179
32 increased circulating specific ige antibody 58 31 occasional (7.5%) Occasional (29-5%) HP:0032336
33 seizure 31 occasional (7.5%) HP:0001250
34 hyperesthesia 58 31 very rare (1%) Very rare (<4-1%) HP:0100963
35 coma 58 31 very rare (1%) Very rare (<4-1%) HP:0001259
36 seizures 58 Occasional (29-5%)
37 muscle weakness 58 Occasional (29-5%)
38 vomiting 58 Frequent (79-30%)
39 pain 58 Occasional (29-5%)
40 unusual cns infection 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Angiostrongyliasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 IL13 IL2 IL4 IL5 MMP9 PLAU
2 immune system MP:0005387 9.61 CCL11 CCL24 IL13 IL2 IL4 IL5
3 respiratory system MP:0005388 9.23 CCL11 CCL24 IL13 IL2 IL4 IL5

Drugs & Therapeutics for Angiostrongyliasis

Search Clinical Trials , NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

Anatomical Context for Angiostrongyliasis

MalaCards organs/tissues related to Angiostrongyliasis:

40
Brain, Eye, Skin, Lung, Spleen, Colon, Bone

Publications for Angiostrongyliasis

Articles related to Angiostrongyliasis:

(show top 50) (show all 431)
# Title Authors PMID Year
1
Tetraventricular Hydrocephalus Following Eosinophilic Meningitis due to Angiostrongylus cantonensis in a 14-Month-Old Boy From Mayotte: A Case Report. 61
33728356 2021
2
Angiostrongylus spp. (Nematoda; Metastrongyloidea) of global public health importance. 61
33160683 2021
3
Peroxisome-Proliferator Activator Receptor γ in Mouse Model with Meningoencephalitis Caused by Angiostrongylus cantonensis. 61
33684197 2021
4
A Hawaii public education programme for rat lungworm disease prevention. 61
32800015 2021
5
Variation in Angiostrongylus cantonensis infection in definitive and intermediate hosts in Hawaii, a global hotspot of rat lungworm disease. 61
32907654 2021
6
Sandwich dot-immunogold filtration assay (DIGFA) for specific immunodiagnosis of active neuroangiostrongyliasis. 61
33004092 2021
7
Human angiostrongyliasis. Some clarifications regarding the case report of an imported case in Spain. 61
33640472 2021
8
An unusual cause of visual loss: Subfoveal, motile angiostrongyliasis. 61
33470180 2021
9
Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis. 61
33236700 2020
10
Identification of cross-reactive markers to strengthen the development of immunodiagnostic methods for angiostrongyliasis and other parasitic infections. 61
32956649 2020
11
AcanR3990 qPCR: a novel, highly sensitive, bioinformatically-informed assay to detect Angiostrongylus cantonensis infections. 61
33252651 2020
12
First record of natural infection by Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) in Belocaulus willibaldoi and Rattus norvegicus in an urban area of São Paulo city, SP, Brazil. 61
33083611 2020
13
Eosinophilic meningitis outbreak related to religious practice. 61
32553843 2020
14
The metagenomic next-generation sequencing in diagnosing central nervous system angiostrongyliasis: a case report. 61
32957922 2020
15
A case of human angiostrongyliasis manifesting as eosinophilic meningitis in Okinawa, Japan. 61
32305672 2020
16
Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report. 61
32502661 2020
17
Abdominal angiostrongyliasis: pathologic findings in Swiss mice infected with different doses of Angiostrongylus costaricensis. 61
32631461 2020
18
Angiostrongyliasis infection masquerading as granulomatosis with polyangiitis: a case-based review. 61
32424614 2020
19
Two Ocular Angiostrongyliasis Cases in Thailand with Molecular Identification of Causative Parasite Species. 61
32228781 2020
20
Abdominal angiostrongyliasis, report of two cases and analysis of published reports from Colombia. 61
32673453 2020
21
The excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis induces autophagy via the Sonic hedgehog pathway in mouse brain astrocytes. 61
32479527 2020
22
Species Identity and Size are Associated with Rat Lungworm Infection in Gastropods. 61
32676832 2020
23
Molecular cloning and characterization of a cathepsin L-like cysteine protease of Angiostrongylus cantonensis. 61
31756482 2020
24
Eosinophilic meningitis due to Angiostrongylus cantonensis in Europe. 61
31972289 2020
25
Development of an immunochromatographic device to detect antibodies for rapid diagnosis of human angiostrongyliasis. 61
31690362 2020
26
A Case Report of Slug Ingestion Causing Eosinophilic Meningitis, Papilledema, and Pronounced Motor Weakness in a US Marine. 61
31436288 2020
27
Gastropods as intermediate hosts of Angiostrongylus spp. in the Americas: bioecological characteristics and geographical distribution. 61
33263610 2020
28
Occurrence of Rat Lungworm (Angiostrongylus cantonensis) in Invasive Coqui Frogs (Eleutherodactylus coqui) and Other Hosts in Hawaii, USA. 61
31295084 2020
29
Estimating Human Exposure to Rat Lungworm (Angiostrongylus cantonensis) on Hawai'i Island: A Pilot Study. 61
31769399 2020
30
Infection by Angiostrongylus cantonensis in both humans and the snail Achatina (Lissachatina) fulica in the city of Macapá, in the Amazon Region of Brazil. 61
32638831 2020
31
Control of eosinopilic meningitis caused by Angiostrongylus cantonensis in China. 61
32563328 2020
32
Abdominal angiostrongyliasis can be diagnosed with a immunochromatographic rapid test with recombinant galactin from Angiostrongylus cantonensis. 61
32965330 2020
33
The first report of cerebral, pulmonary and gastrointestinal angiostrongyliasis in the water rat Hydromys chrysogaster from Queensland, Australia. 61
30141384 2019
34
Invasive slug Meghimatium pictum (Stoliczka, 1873) infected by Angiostrongylus costaricensis Morera & Céspedes, 1971, and the possible risk of human infection associated with grape consumption. 61
30205852 2019
35
The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome. 61
31751335 2019
36
Application of Recombinant Angiostrongylus cantonensis Galectin-2 Protein for Serodiagnosis of Human Angiostrongyliasis by Immunoblotting. 61
31392957 2019
37
First record of Bulimulus tenuissimus (Mollusca) as potential experimental intermediate host of Angiostrongylus cantonensis (Nematoda). 61
30379205 2019
38
Review of Cases of Angiostrongyliasis in Hawaii, 2007-2017. 61
31287041 2019
39
Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China. 61
31313505 2019
40
Severe CNS angiostrongyliasis in a young marine: a case report and literature review. 61
30454904 2019
41
Molecular phylogeography and genetic diversity of Angiostrongylus cantonensis and A. malaysiensis (Nematoda: Angiostrongylidae) based on 66-kDa protein gene. 61
30267903 2019
42
Proteomic analysis of excretory-secretory products from young adults of Angiostrongylus cantonensis. 61
31241649 2019
43
Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand. 61
31560712 2019
44
Modelling the distribution in Hawaii of Angiostrongylus cantonensis (rat lungworm) in its gastropod hosts. 61
29925459 2019
45
Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice. 61
31636619 2019
46
Ocular angiostrongyliasis in Thailand: a retrospective analysis over two decades. 61
31417234 2019
47
A survey of freshwater and terrestrial snails in a predominantly urban municipality of Rio de Janeiro State, Brazil, with emphasis on human parasites vectors. 61
30517246 2018
48
High-dose enoxaparin in the treatment of abdominal angiostrongyliasis in Swiss mice. 61
28969719 2018
49
Small-scale spatial analysis of intermediate and definitive hosts of Angiostrongylus cantonensis. 61
30318019 2018
50
Shedding of Angiostrongylus costaricensis larvae in the faeces of Swiss mice experimentally infected with different infective doses. 61
30353797 2018

Variations for Angiostrongyliasis

Expression for Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for Angiostrongyliasis

Pathways related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 IL5 IL4 IL2 IL13 CCL24 CCL11
2
Show member pathways
13.23 IL5 IL4 IL2 IL13 CCL24 CCL11
3
Show member pathways
13.17 MMP9 IL5 IL4 IL2 IL13 CCL11
4
Show member pathways
13.12 IL5 IL4 IL2 IL13 CCL24 CCL11
5 12.66 MMP9 IL5 IL4 IL2 IL13
6
Show member pathways
12.66 IL5 IL4 IL2 IL13 CCL11
7
Show member pathways
12.44 IL5 IL4 IL2 IL13
8
Show member pathways
12.26 IL5 IL4 IL2 IL13
9
Show member pathways
12.1 IL5 IL4 IL2 IL13
10
Show member pathways
12.1 MMP9 IL5 IL4 IL13 CCL11
11
Show member pathways
11.89 IL5 IL2 IL13
12 11.87 MMP9 IL4 IL2
13 11.85 IL5 IL4 IL2
14 11.84 MMP9 IL4 IL13 CCL11
15 11.65 IL5 IL4 IL2 IL13
16
Show member pathways
11.62 IL5 IL4 IL2
17 11.61 IL5 IL4 IL2 IL13
18 11.52 IL5 IL4 CCL11
19 11.2 IL5 IL4 IL2
20 11.18 IL5 IL4 IL13
21 11.08 IL2 IL13
22 11.02 IL5 IL4 IL2 IL13
23 11.02 IL5 IL4 IL2 IL13 CCL11
24 10.9 PLAU MMP9 IL5 IL4 IL13 CCL11
25 10.87 IL5 IL4 IL2 IL13
26 10.84 IL5 IL4 IL2 IL13 CCL24 CCL11
27 10.58 IL5 IL4 IL13

GO Terms for Angiostrongyliasis

Cellular components related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 PLAU MMP9 IL5 IL4 IL2 IL13
2 extracellular space GO:0005615 9.23 PLAU MMP9 IL5 IL4 IL2 IL13

Biological processes related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 IL5 IL4 IL2 CLDN5
2 inflammatory response GO:0006954 9.83 IL5 IL13 CCL24 CCL11
3 chemotaxis GO:0006935 9.74 PLAU CCL24 CCL11
4 negative regulation of inflammatory response GO:0050728 9.71 IL4 IL2 IL13
5 response to ethanol GO:0045471 9.69 IL2 IL13 CLDN5
6 positive regulation of cell migration GO:0030335 9.65 PLAU MMP9 IL4 CCL24 CCL11
7 immune response GO:0006955 9.63 IL5 IL4 IL2 IL13 CCL24 CCL11
8 microglial cell activation GO:0001774 9.58 IL4 IL13
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL4 IL2 IL13
10 positive regulation of T cell differentiation GO:0045582 9.56 IL4 IL2
11 eosinophil chemotaxis GO:0048245 9.55 CCL24 CCL11
12 positive regulation of immunoglobulin production GO:0002639 9.5 IL5 IL2 IL13
13 macrophage activation GO:0042116 9.49 IL4 IL13
14 negative regulation of T-helper 17 cell differentiation GO:2000320 9.48 IL4 IL2
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 IL4 IL2
16 positive regulation of mast cell degranulation GO:0043306 9.43 IL4 IL13
17 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL4 IL13
18 positive regulation of B cell proliferation GO:0030890 9.26 IL5 IL4 IL2 IL13
19 cytokine-mediated signaling pathway GO:0019221 9.1 MMP9 IL5 IL4 IL2 IL13 CCL11

Molecular functions related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL5 IL4 IL2
2 CCR chemokine receptor binding GO:0048020 9.32 CCL24 CCL11
3 cytokine receptor binding GO:0005126 9.26 IL4 IL13
4 cytokine activity GO:0005125 9.1 IL5 IL4 IL2 IL13 CCL24 CCL11
5 CCR3 chemokine receptor binding GO:0031728 8.96 CCL24 CCL11

Sources for Angiostrongyliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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