MCID: ANG002
MIFTS: 44

Angiostrongyliasis

Categories: Eye diseases, Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Angiostrongyliasis

MalaCards integrated aliases for Angiostrongyliasis:

Name: Angiostrongyliasis 12 77 54 60 15 74

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050256
ICD10 34 B83.2
MESH via Orphanet 46 C536369
ICD10 via Orphanet 35 B81.3 B83.2
UMLS via Orphanet 75 C0392662
Orphanet 60 ORPHA74
UMLS 74 C0392662

Summaries for Angiostrongyliasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.

MalaCards based summary : Angiostrongyliasis is related to eosinophilic meningitis and meningitis. An important gene associated with Angiostrongyliasis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and lung, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 77 Angiostrongyliasis is an infection by a roundworm of the Angiostrongylus type. Symptoms may vary from... more...

Related Diseases for Angiostrongyliasis

Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 eosinophilic meningitis 29.2 CCL11 IL13 IL4 IL5 MMP9 PLAU
2 meningitis 10.6
3 optic neuritis 10.2
4 neuritis 10.2
5 blepharitis 10.2 CCL11 MMP9
6 meningoencephalitis 10.2
7 appendicitis 10.2
8 aortic aneurysm, familial abdominal, 1 10.1 MMP9 PLAU
9 pemphigoid gestationis 10.1 CCL11 IL5
10 eosinophilic gastroenteritis 10.1 CCL11 IL5
11 tropical spastic paraparesis 10.1 IL2 MMP9
12 chronic eosinophilic pneumonia 10.1 CCL11 IL5
13 cytokine deficiency 10.1 IL13 IL5
14 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5
15 intervertebral disc disease 10.1 IL2 MMP9
16 respiratory syncytial virus infectious disease 10.1 IL13 IL5
17 paragonimiasis 10.1 IL13 IL5
18 ascaris lumbricoides infection 10.0 IL13 IL5
19 pollen allergy 10.0 IL13 IL5
20 chromoblastomycosis 10.0 IL4 MMP9
21 enterocolitis 10.0
22 colitis 10.0
23 anisakiasis 10.0
24 blepharoconjunctivitis 10.0 CCL11 IL4
25 papillary conjunctivitis 10.0 CCL11 IL4
26 wells syndrome 10.0 IL2 IL5
27 giant papillary conjunctivitis 10.0 CCL11 IL4
28 gastrointestinal system disease 10.0 CCL11 IL2 MMP9
29 pulmonary disease, chronic obstructive 10.0 CCL11 IL13 MMP9
30 virus associated hemophagocytic syndrome 9.9 IL2 IL4
31 autoimmune vasculitis 9.9 IL2 IL4
32 chronic meningitis 9.9 CCL11 IL5 MMP9
33 penicillin allergy 9.9 IL13 IL4
34 jak3-deficient severe combined immunodeficiency 9.9 IL2 IL4
35 filariasis 9.9 IL2 IL5
36 beta-lactam allergy 9.9 IL13 IL4
37 allergic contact dermatitis 9.9 IL4 IL5
38 contact dermatitis 9.9 IL4 IL5
39 autoimmune gastritis 9.9 IL2 IL4
40 vulvovaginal candidiasis 9.9 IL2 IL4
41 mycoplasma pneumoniae pneumonia 9.9 IL13 IL4
42 coccidiosis 9.9 IL2 IL4
43 severe combined immunodeficiency, x-linked 9.9 IL2 IL4
44 cough variant asthma 9.9 IL4 IL5
45 egg allergy 9.9 IL4 IL5
46 vernal conjunctivitis 9.9 IL2 IL4
47 sulfamethoxazole allergy 9.9 IL4 IL5
48 aphthous stomatitis 9.9 IL2 IL4
49 intrinsic asthma 9.9 IL4 IL5
50 acute graft versus host disease 9.9 IL2 IL4

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to Angiostrongyliasis

Symptoms & Phenotypes for Angiostrongyliasis

MGI Mouse Phenotypes related to Angiostrongyliasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.88 IL13 IL2 IL4 IL5 MMP9 PLAU
2 hematopoietic system MP:0005397 9.87 CCL11 IL13 IL2 IL4 IL5 MMP9
3 growth/size/body region MP:0005378 9.85 IL13 IL2 IL4 IL5 MMP9 PLAU
4 immune system MP:0005387 9.8 CCL11 IL13 IL2 IL4 IL5 MMP9
5 neoplasm MP:0002006 9.46 IL2 IL5 MMP9 PLAU
6 reproductive system MP:0005389 9.43 IL13 IL2 IL4 IL5 MMP9 PLAU
7 respiratory system MP:0005388 9.17 CCL11 IL13 IL2 IL4 IL5 MMP9

Drugs & Therapeutics for Angiostrongyliasis

Drugs for Angiostrongyliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

Anatomical Context for Angiostrongyliasis

MalaCards organs/tissues related to Angiostrongyliasis:

42
Eye, Testes, Lung, Skin, Liver, Colon

Publications for Angiostrongyliasis

Articles related to Angiostrongyliasis:

(show top 50) (show all 151)
# Title Authors Year
1
Pediatric angiostrongyliasis. ( 29616650 )
2018
2
Immunochromatographic test for rapid serological diagnosis of human angiostrongyliasis. ( 29908250 )
2018
3
Diagnosing and Understanding Angiostrongyliasis, A Zoonotic Cause of Meningitis. ( 29411969 )
2018
4
The first report of cerebral, pulmonary and gastrointestinal angiostrongyliasis in the water rat Hydromys chrysogaster from Queensland, Australia. ( 30141384 )
2018
5
Severe CNS angiostrongyliasis in a young marine: a case report and literature review. ( 30454904 )
2018
6
Angiostrongyliasis (Rat Lungworm Disease): Viewpoints from Hawai'i Island. ( 28820576 )
2017
7
High-dose enoxaparin in the treatment of abdominal angiostrongyliasis in Swiss mice. ( 28969719 )
2017
8
First Evidence of Angiostrongyliasis Caused by Angiostrongylus cantonensis in Guadeloupe, Lesser Antilles. ( 28070007 )
2017
9
Abdominal Angiostrongyliasis: A Presentation of Eosinophilic Granulomatous Colitis. ( 29278974 )
2017
10
Cloning and expression of a 16-kDa recombinant protein from Angiostrongylus cantonensis for use in immunoblot diagnosis of human angiostrongyliasis. ( 27406573 )
2016
11
A Case of Ocular Angiostrongyliasis with Molecular Identification of the Species in Vietnam. ( 26797438 )
2015
12
Emergence of neural angiostrongyliasis in eastern australia. ( 25793473 )
2015
13
Abdominal angiostrongyliasis mimicking acute appendicitis. ( 25928828 )
2015
14
PCR for the diagnosis of abdominal angiostrongyliasis in formalin-fixed paraffin-embedded human tissue. ( 24705328 )
2014
15
Follow-up on anterior chamber angiostrongyliasis. ( 25124954 )
2014
16
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
17
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. ( 23901379 )
2013
18
Neuroimaging features in neuro-gnathostomiasis and angiostrongyliasis. ( 22271262 )
2013
19
Endemic angiostrongyliasis in the Brazilian Amazon: natural parasitism of Angiostrongylus cantonensis in Rattus rattus and R. norvegicus, and sympatric giant African land snails, Achatina fulica. ( 23072946 )
2013
20
Comprehensive review of ocular angiostrongyliasis with special reference to optic neuritis. ( 24516263 )
2013
21
Differential diagnosis of CNS angiostrongyliasis: a short review. ( 23901385 )
2013
22
The role of eosinophils in angiostrongyliasis: multiple roles for a versatile cell? ( 23901384 )
2013
23
Subretinal angiostrongyliasis-induced optic neuritis. ( 23818750 )
2013
24
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. ( 23390222 )
2013
25
Anterior chamber angiostrongyliasis. ( 23846206 )
2013
26
Pathways for transmission of angiostrongyliasis and the risk of disease associated with them. ( 23901388 )
2013
27
Workshop on research priorities for management and treatment of angiostrongyliasis(1). ( 23171634 )
2012
28
How can clinicians ensure the diagnosis of meningitic angiostrongyliasis? ( 21923259 )
2012
29
A comparative study of neuroimaging features between human neuro-gnathostomiasis and angiostrongyliasis. ( 22124854 )
2012
30
Enzootic angiostrongyliasis in Guangzhou, China, 2008-2010. ( 22556086 )
2012
31
Development of a double antibody sandwich ELISA assay for the diagnosis of angiostrongyliasis. ( 21506824 )
2011
32
Endemic angiostrongyliasis, Rio de Janeiro, Brazil. ( 21762612 )
2011
33
Enzootic angiostrongyliasis, Guangdong, China, 2008-2009. ( 21762614 )
2011
34
Human ocular angiostrongyliasis: a literature review. ( 21296846 )
2011
35
International symposium on Angiostrongylus and Angiostrongyliasis, 2010. ( 21762566 )
2011
36
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. ( 21363978 )
2011
37
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. ( 21513853 )
2011
38
An indirect immunofluorescence antibody test employing whole eggs as the antigen for the diagnosis of abdominal angiostrongyliasis. ( 21739024 )
2011
39
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. ( 22299428 )
2011
40
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. ( 21400113 )
2011
41
Abdominal angiostrongyliasis with involvement of liver histopathologically confirmed: a case report. ( 21915466 )
2011
42
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. ( 21294950 )
2011
43
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. ( 19545957 )
2010
44
Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals. ( 21120370 )
2010
45
Use of heterologous antigens for the immunodiagnosis of abdominal angiostrongyliasis by an enzyme-linked immunosorbent assay. ( 21120363 )
2010
46
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. ( 21073053 )
2010
47
Identification of factors associated with clinically severe angiostrongyliasis. ( 21118948 )
2010
48
Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. ( 20584616 )
2010
49
An outbreak of angiostrongyliasis cantonensis in Beijing. ( 19874073 )
2010
50
Colon mass secondary to angiostrongyliasis. ( 19345351 )
2009

Variations for Angiostrongyliasis

Expression for Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for Angiostrongyliasis

Pathways related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 CCL11 IL13 IL2 IL4 IL5 MMP9
2
Show member pathways
13.42 CCL11 IL13 IL2 IL4 IL5
3
Show member pathways
13.29 CCL11 IL13 IL2 IL4 IL5
4
Show member pathways
13.19 CCL11 IL13 IL2 IL4 IL5
5
Show member pathways
13.14 CCL11 IL13 IL2 IL4 IL5 MMP9
6
Show member pathways
13.1 CCL11 IL13 IL2 IL4 IL5
7
Show member pathways
12.7 CCL11 IL13 IL2 IL4 IL5
8 12.65 IL13 IL2 IL4 IL5 MMP9
9
Show member pathways
12.44 IL13 IL2 IL4 IL5
10
Show member pathways
12.39 IL13 IL4 IL5
11
Show member pathways
12.26 IL13 IL2 IL5
12
Show member pathways
12.25 IL13 IL2 IL4 IL5
13
Show member pathways
12.24 IL2 IL4 IL5
14
Show member pathways
12.13 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.11 IL13 IL2 IL4 IL5
16
Show member pathways
11.91 IL13 IL4 MMP9
17
Show member pathways
11.9 IL13 IL2 IL5
18
Show member pathways
11.89 CCL11 IL13 IL2 IL4 IL5
19 11.88 IL2 IL4 MMP9
20 11.86 IL2 IL4 IL5
21 11.85 CCL11 IL13 IL4 MMP9
22 11.67 IL13 IL2 IL4 IL5
23
Show member pathways
11.65 IL2 IL4 IL5
24 11.64 IL13 IL2 IL4 IL5
25 11.55 CCL11 IL4 IL5
26
Show member pathways
11.52 IL2 IL4
27 11.5 MMP9 PLAU
28
Show member pathways
11.49 IL2 MMP9
29 11.47 MMP9 PLAU
30 11.4 CCL11 IL13 IL2 IL4 MMP9
31 11.37 IL13 IL4
32 11.35 MMP9 PLAU
33 11.34 MMP9 PLAU
34
Show member pathways
11.32 MMP9 PLAU
35 11.23 IL2 IL4 IL5
36 11.19 MMP9 PLAU
37 11.19 IL13 IL4 IL5
38 11.09 IL13 IL2
39 11.09 IL13 IL2 IL4 IL5
40 11.02 CCL11 IL13 IL2 IL4 IL5
41 11 CCL11 IL13 IL2 IL4 IL5
42 10.97 IL13 IL2 IL4 IL5
43 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
44 10.85 CCL11 IL13 IL2 IL4 IL5

GO Terms for Angiostrongyliasis

Cellular components related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 IL13 IL2 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 IL13 IL2 IL4 IL5 MMP9

Biological processes related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.69 CCL11 IL13 IL5
2 positive regulation of cell migration GO:0030335 9.65 CCL11 MMP9 PLAU
3 immune response GO:0006955 9.65 CCL11 IL13 IL2 IL4 IL5
4 regulation of signaling receptor activity GO:0010469 9.63 CCL11 IL13 IL2 IL4 IL5 PLAU
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL13 IL2 IL4
6 positive regulation of T cell proliferation GO:0042102 9.52 IL2 IL4
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 IL13 IL4
8 positive regulation of T cell differentiation GO:0045582 9.46 IL2 IL4
9 positive regulation of immunoglobulin secretion GO:0051024 9.43 IL2 IL5
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 IL2 IL4
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
12 positive regulation of B cell proliferation GO:0030890 9.26 IL13 IL2 IL4 IL5
13 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 IL13 IL2 IL4 IL5 MMP9

Molecular functions related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL2 IL4 IL5
3 cytokine activity GO:0005125 9.02 CCL11 IL13 IL2 IL4 IL5

Sources for Angiostrongyliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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