MCID: ANG002
MIFTS: 43

Angiostrongyliasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Angiostrongyliasis

MalaCards integrated aliases for Angiostrongyliasis:

Name: Angiostrongyliasis 12 76 53 59 15 73

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050256
Orphanet 59 ORPHA74
ICD10 via Orphanet 34 B81.3 B83.2
MESH via Orphanet 45 C536369
UMLS via Orphanet 74 C0392662
ICD10 33 B83.2
UMLS 73 C0392662

Summaries for Angiostrongyliasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis.

MalaCards based summary : Angiostrongyliasis is related to eosinophilic meningitis and intratubular embryonal carcinoma. An important gene associated with Angiostrongyliasis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include eye, kidney and testes, and related phenotypes are digestive/alimentary and hematopoietic system

Wikipedia : 76 Angiostrongyliasis is a zoonotic infection by a nematode from the kidney and alimentary tract roundworm... more...

Related Diseases for Angiostrongyliasis

Diseases related to Angiostrongyliasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 eosinophilic meningitis 27.2 CCL11 IL13 IL4 IL5 MMP9 PLAU
2 intratubular embryonal carcinoma 10.5 MMP9 PLAU
3 meningitis 10.4
4 pemphigoid gestationis 10.3 CCL11 IL5
5 tropical spastic paraparesis 10.2 IL2 MMP9
6 eosinophilic gastroenteritis 10.2 CCL11 IL5
7 chronic eosinophilic pneumonia 10.2 CCL11 IL5
8 cytokine deficiency 10.2 IL13 IL5
9 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5
10 respiratory syncytial virus infectious disease 10.1 IL13 IL5
11 paragonimiasis 10.1 IL13 IL5
12 ascaris lumbricoides infection 10.1 IL13 IL5
13 optic neuritis 10.1
14 neuritis 10.1
15 pollen allergy 10.1 IL13 IL5
16 chromoblastomycosis 10.0 IL4 MMP9
17 blepharoconjunctivitis 10.0 CCL11 IL4
18 esophageal disease 10.0 IL13 IL5
19 papillary conjunctivitis 10.0 CCL11 IL4
20 wells syndrome 10.0 IL2 IL5
21 giant papillary conjunctivitis 10.0 CCL11 IL4
22 meningoencephalitis 10.0
23 appendicitis 10.0
24 mast cell disease 10.0 IL13 IL5
25 pulmonary disease, chronic obstructive 9.9 CCL11 IL13 MMP9
26 secondary progressive multiple sclerosis 9.9 IL4 MMP9
27 virus associated hemophagocytic syndrome 9.9 IL2 IL4
28 filariasis 9.9 IL2 IL5
29 chronic meningitis 9.9 CCL11 IL5 MMP9
30 penicillin allergy 9.9 IL13 IL4
31 dermatitis herpetiformis 9.9 CCL11 IL4
32 jak3-deficient severe combined immunodeficiency 9.9 IL2 IL4
33 beta-lactam allergy 9.9 IL13 IL4
34 microscopic colitis 9.8 IL2 IL4
35 enterocolitis 9.8
36 colitis 9.8
37 anisakiasis 9.8
38 vulvovaginal candidiasis 9.8 IL2 IL4
39 coccidiosis 9.8 IL2 IL4
40 severe combined immunodeficiency, x-linked 9.8 IL2 IL4
41 gingivitis 9.8 IL4 MMP9
42 cough variant asthma 9.8 IL4 IL5
43 acute graft versus host disease 9.8 IL2 IL4
44 egg allergy 9.8 IL4 IL5
45 vernal conjunctivitis 9.8 IL2 IL4
46 intrinsic asthma 9.8 IL4 IL5
47 trichinosis 9.7 IL4 IL5
48 brucellosis 9.7 IL2 IL4
49 non-suppurative otitis media 9.7 IL4 IL5
50 cercarial dermatitis 9.7 IL4 IL5

Graphical network of the top 20 diseases related to Angiostrongyliasis:



Diseases related to Angiostrongyliasis

Symptoms & Phenotypes for Angiostrongyliasis

MGI Mouse Phenotypes related to Angiostrongyliasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.88 IL4 IL5 MMP9 IL13 PLAU IL2
2 hematopoietic system MP:0005397 9.87 IL4 IL5 CCL11 MMP9 IL13 PLAU
3 growth/size/body region MP:0005378 9.85 IL4 IL5 MMP9 IL13 PLAU IL2
4 immune system MP:0005387 9.8 IL4 IL5 CCL11 MMP9 IL13 PLAU
5 neoplasm MP:0002006 9.46 IL5 MMP9 PLAU IL2
6 reproductive system MP:0005389 9.43 IL4 IL5 MMP9 IL13 PLAU IL2
7 respiratory system MP:0005388 9.17 IL4 IL5 CCL11 MMP9 IL13 PLAU

Drugs & Therapeutics for Angiostrongyliasis

Drugs for Angiostrongyliasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882

Search NIH Clinical Center for Angiostrongyliasis

Genetic Tests for Angiostrongyliasis

Anatomical Context for Angiostrongyliasis

MalaCards organs/tissues related to Angiostrongyliasis:

41
Eye, Kidney, Testes, Skin, Liver, Colon, Lung

Publications for Angiostrongyliasis

Articles related to Angiostrongyliasis:

(show top 50) (show all 145)
# Title Authors Year
1
Pediatric angiostrongyliasis. ( 29616650 )
2018
2
Immunochromatographic test for rapid serological diagnosis of human angiostrongyliasis. ( 29908250 )
2018
3
Diagnosing and Understanding Angiostrongyliasis, A Zoonotic Cause of Meningitis. ( 29411969 )
2018
4
Angiostrongyliasis (Rat Lungworm Disease): Viewpoints from Hawai'i Island. ( 28820576 )
2017
5
High-dose enoxaparin in the treatment of abdominal angiostrongyliasis in Swiss mice. ( 28969719 )
2017
6
First Evidence of Angiostrongyliasis Caused by Angiostrongylus cantonensis in Guadeloupe, Lesser Antilles. ( 28070007 )
2017
7
Abdominal Angiostrongyliasis: A Presentation of Eosinophilic Granulomatous Colitis. ( 29278974 )
2017
8
Cloning and expression of a 16-kDa recombinant protein from Angiostrongylus cantonensis for use in immunoblot diagnosis of human angiostrongyliasis. ( 27406573 )
2016
9
A Case of Ocular Angiostrongyliasis with Molecular Identification of the Species in Vietnam. ( 26797438 )
2015
10
Emergence of neural angiostrongyliasis in eastern australia. ( 25793473 )
2015
11
Abdominal angiostrongyliasis mimicking acute appendicitis. ( 25928828 )
2015
12
PCR for the diagnosis of abdominal angiostrongyliasis in formalin-fixed paraffin-embedded human tissue. ( 24705328 )
2014
13
Follow-up on anterior chamber angiostrongyliasis. ( 25124954 )
2014
14
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
15
Angiostrongyliasis in Thailand: epidemiology and laboratory investigations. ( 23901379 )
2013
16
Neuroimaging features in neuro-gnathostomiasis and angiostrongyliasis. ( 22271262 )
2013
17
Endemic angiostrongyliasis in the Brazilian Amazon: natural parasitism of Angiostrongylus cantonensis in Rattus rattus and R. norvegicus, and sympatric giant African land snails, Achatina fulica. ( 23072946 )
2013
18
Comprehensive review of ocular angiostrongyliasis with special reference to optic neuritis. ( 24516263 )
2013
19
Differential diagnosis of CNS angiostrongyliasis: a short review. ( 23901385 )
2013
20
The role of eosinophils in angiostrongyliasis: multiple roles for a versatile cell? ( 23901384 )
2013
21
Subretinal angiostrongyliasis-induced optic neuritis. ( 23818750 )
2013
22
Intrathecal activation as a typical immune response within the central nervous system in angiostrongyliasis. ( 23390222 )
2013
23
Anterior chamber angiostrongyliasis. ( 23846206 )
2013
24
Pathways for transmission of angiostrongyliasis and the risk of disease associated with them. ( 23901388 )
2013
25
Workshop on research priorities for management and treatment of angiostrongyliasis(1). ( 23171634 )
2012
26
How can clinicians ensure the diagnosis of meningitic angiostrongyliasis? ( 21923259 )
2012
27
A comparative study of neuroimaging features between human neuro-gnathostomiasis and angiostrongyliasis. ( 22124854 )
2012
28
Enzootic angiostrongyliasis in Guangzhou, China, 2008-2010. ( 22556086 )
2012
29
Development of a double antibody sandwich ELISA assay for the diagnosis of angiostrongyliasis. ( 21506824 )
2011
30
Endemic angiostrongyliasis, Rio de Janeiro, Brazil. ( 21762612 )
2011
31
Enzootic angiostrongyliasis, Guangdong, China, 2008-2009. ( 21762614 )
2011
32
Human ocular angiostrongyliasis: a literature review. ( 21296846 )
2011
33
International symposium on Angiostrongylus and Angiostrongyliasis, 2010. ( 21762566 )
2011
34
Comparison of major immunoglobulins intrathecal synthesis patterns in Ecuadorian and Cuban patients with angiostrongyliasis. ( 21363978 )
2011
35
Lung CT findings of angiostrongyliasis cantonensis caused by Angiostrongylus cantonensis. ( 21513853 )
2011
36
An indirect immunofluorescence antibody test employing whole eggs as the antigen for the diagnosis of abdominal angiostrongyliasis. ( 21739024 )
2011
37
An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease. ( 22299428 )
2011
38
Outcomes in mice with abdominal angiostrongyliasis treated with enoxaparin. ( 21400113 )
2011
39
Abdominal angiostrongyliasis with involvement of liver histopathologically confirmed: a case report. ( 21915466 )
2011
40
Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study. ( 21294950 )
2011
41
Abdominal angiostrongyliasis caused by Angiostrongylus cantonensis: a possible cause of eosinophilic infiltration in human digestive tract. ( 19545957 )
2010
42
Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals. ( 21120370 )
2010
43
Use of heterologous antigens for the immunodiagnosis of abdominal angiostrongyliasis by an enzyme-linked immunosorbent assay. ( 21120363 )
2010
44
Application of recombinant SMR-domain containing protein of angiostrongylus cantonensis in immunoblot diagnosis of human angiostrongyliasis. ( 21073053 )
2010
45
Identification of factors associated with clinically severe angiostrongyliasis. ( 21118948 )
2010
46
Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. ( 20584616 )
2010
47
Colon mass secondary to angiostrongyliasis. ( 19345351 )
2009
48
Thai koi-hoi snail dish and angiostrongyliasis due to Angiostrongylus cantonensis: Effects of food flavoring and alcoholic drink on the third-stage larvae in infected snail meat. ( 19272010 )
2009
49
Angiostrongyliasis in the Americas. ( 19523320 )
2009
50
Human angiostrongyliasis outbreak in Dali, China. ( 19771154 )
2009

Variations for Angiostrongyliasis

Expression for Angiostrongyliasis

Search GEO for disease gene expression data for Angiostrongyliasis.

Pathways for Angiostrongyliasis

Pathways related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 CCL11 IL13 IL2 IL4 IL5 MMP9
2
Show member pathways
13.4 CCL11 IL13 IL2 IL4 IL5
3
Show member pathways
13.26 CCL11 IL13 IL2 IL4 IL5
4
Show member pathways
13.16 CCL11 IL13 IL2 IL4 IL5
5
Show member pathways
13.11 CCL11 IL13 IL2 IL4 IL5 MMP9
6
Show member pathways
13.07 CCL11 IL13 IL2 IL4 IL5
7
Show member pathways
12.67 CCL11 IL13 IL2 IL4 IL5
8 12.63 IL13 IL2 IL4 IL5 MMP9
9
Show member pathways
12.46 IL13 IL2 IL4 IL5
10
Show member pathways
12.37 IL13 IL4 IL5
11
Show member pathways
12.27 IL13 IL2 IL4 IL5
12
Show member pathways
12.24 IL13 IL2 IL5
13
Show member pathways
12.22 IL2 IL4 IL5
14
Show member pathways
12.05 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
11.88 IL13 IL2 IL5
16
Show member pathways
11.87 CCL11 IL13 IL2 IL4 IL5
17 11.85 IL2 IL4 MMP9
18 11.83 IL2 IL4 IL5
19 11.79 CCL11 IL13 IL4 MMP9
20
Show member pathways
11.63 IL2 IL4 IL5
21 11.62 IL13 IL2 IL4 IL5
22 11.57 IL13 IL2 IL4 IL5
23 11.53 CCL11 IL4 IL5
24
Show member pathways
11.5 IL2 IL4
25 11.49 MMP9 PLAU
26
Show member pathways
11.47 IL2 MMP9
27 11.45 MMP9 PLAU
28 11.35 IL13 IL4
29 11.34 MMP9 PLAU
30 11.32 MMP9 PLAU
31
Show member pathways
11.3 MMP9 PLAU
32 11.19 IL2 IL4 IL5
33 11.17 MMP9 PLAU
34 11.16 IL13 IL4 IL5
35 11.08 IL13 IL2
36 11.03 IL13 IL2 IL4 IL5
37 11.02 CCL11 IL13 IL2 IL4 IL5
38 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
39 10.87 IL13 IL2 IL4 IL5

GO Terms for Angiostrongyliasis

Cellular components related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 IL13 IL2 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 IL13 IL2 IL4 IL5 MMP9

Biological processes related to Angiostrongyliasis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.69 CCL11 IL13 IL5
2 immune response GO:0006955 9.65 CCL11 IL13 IL2 IL4 IL5
3 positive regulation of cell migration GO:0030335 9.63 CCL11 MMP9 PLAU
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IL13 IL2
5 positive regulation of T cell proliferation GO:0042102 9.49 IL2 IL4
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL13 IL4
7 positive regulation of B cell proliferation GO:0030890 9.46 IL13 IL2 IL4 IL5
8 positive regulation of T cell differentiation GO:0045582 9.43 IL2 IL4
9 regulation of signaling receptor activity GO:0010469 9.43 CCL11 IL13 IL2 IL4 IL5 PLAU
10 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL5
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.37 IL2 IL4
12 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
13 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 IL13 IL2 IL4 IL5 MMP9

Molecular functions related to Angiostrongyliasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL2 IL4 IL5
3 cytokine activity GO:0005125 9.02 CCL11 IL13 IL2 IL4 IL5

Sources for Angiostrongyliasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....