MCID: ANG061
MIFTS: 33

Angular Cheilitis

Categories: Oral diseases

Aliases & Classifications for Angular Cheilitis

MalaCards integrated aliases for Angular Cheilitis:

Name: Angular Cheilitis 12 15 74
Cheilosis 12 74
Commissural Cheilitis 12
Angular Stomatitis 12
Angular Cheilosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060312
NCIt 51 C112198
SNOMED-CT 69 81670006
ICD10 34 K13.0

Summaries for Angular Cheilitis

Disease Ontology : 12 A cheilitis characterized by inflammation of one or both of the corners of the mouth.

MalaCards based summary : Angular Cheilitis, also known as cheilosis, is related to actinic cheilitis and ichthyosis follicularis atrichia photophobia syndrome. An important gene associated with Angular Cheilitis is MBTPS2 (Membrane Bound Transcription Factor Peptidase, Site 2), and among its related pathways/superpathways are Unfolded Protein Response (UPR) and Cell cycle. Affiliated tissues include skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Angular cheilitis (AC) is inflammation of one or both corners of the mouth. Often the corners are red... more...

Related Diseases for Angular Cheilitis

Graphical network of the top 20 diseases related to Angular Cheilitis:



Diseases related to Angular Cheilitis

Symptoms & Phenotypes for Angular Cheilitis

GenomeRNAi Phenotypes related to Angular Cheilitis according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.5 MEN1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.5 GFPT1 GFPT2 MEN1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.5 GFPT1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.5 GFPT1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.5 GFPT2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.5 GFPT2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.5 GFPT1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.5 GFPT1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.5 GFPT2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.5 MEN1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.5 GFPT1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.5 GFPT1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.5 MEN1

Drugs & Therapeutics for Angular Cheilitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dental Hygienist Support Promotes Good Oral Health in Nursing Homes Completed NCT02676453 Not Applicable
2 Periodontal Outcomes After Sanative Therapy Enrolling by invitation NCT03649789

Search NIH Clinical Center for Angular Cheilitis

Genetic Tests for Angular Cheilitis

Anatomical Context for Angular Cheilitis

MalaCards organs/tissues related to Angular Cheilitis:

42
Skin

Publications for Angular Cheilitis

Articles related to Angular Cheilitis:

(show top 50) (show all 77)
# Title Authors Year
1
Recurrent angular cheilitis after secukinumab injections. ( 28620989 )
2018
2
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: A case report. ( 29733533 )
2018
3
Angular cheilitis induced by iron deficiency anemia. ( 30102595 )
2018
4
Hyaluronic acid dermal fillers in the management of recurrent angular cheilitis: a case report. ( 30095087 )
2018
5
Angular cheilitis: A clinical and microbial study. ( 29256466 )
2017
6
Actinic cheilosis: early intervention prevents malignant transformation. ( 28320702 )
2017
7
Recurrent angular cheilitis in a patient with mucocutaneous pemphigus vulgaris. ( 25788140 )
2015
8
Evaluation of vermillion border descriptors and relevance vector machines discrimination model for making probabilistic predictions of solar cheilosis on digital lip photographs. ( 26001851 )
2015
9
How do I manage a patient with angular cheilitis? ( 23763743 )
2013
10
Angular cheilitis: a maligned condition. ( 24053003 )
2013
11
Fissures near mouth. Angular cheilitis (perlèche). ( 24482867 )
2013
12
Soreness around mouth. Contact dermatitis and angular cheilitis (perlèche). ( 24482868 )
2013
13
Comparative study on the microbiological features of angular cheilitis in HIV seropositive and HIV seronegative patients from South India. ( 24574650 )
2013
14
Angular cheilitis after paroxetine treatment. ( 22217958 )
2012
15
Solar cheilosis: an ominous precursor: part I. Diagnostic insights. ( 22243721 )
2012
16
Solar cheilosis: an ominous precursor part II. Therapeutic perspectives. ( 22243722 )
2012
17
Organised angular cheilitis as the initial sign of Crohn's disease in two children. ( 21243320 )
2011
18
Angular cheilitis, part 1: local etiologies. ( 21838086 )
2011
19
Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment. ( 21877503 )
2011
20
The clinical features of angular cheilitis occurring during orthodontic treatment: a multi-centre observational study. ( 20567030 )
2010
21
Oral candidiasis and angular cheilitis. ( 20597942 )
2010
22
Angular cheilitis occurring during orthodontic treatment: a case series. ( 19074360 )
2008
23
Dermacase. Angular cheilitis. ( 17882763 )
2007
24
Prosthodontic management of angular cheilitis and persistent drooling: a case report. ( 18018392 )
2007
25
The patient with actinic cheilosis. ( 16903202 )
2006
26
Clinical inquiries. What is angular cheilitis and how is it treated? ( 15865910 )
2005
27
Nickel-induced angular cheilitis due to orthodontic braces. ( 12868984 )
2003
28
Mustache grooming associated with angular cheilitis. ( 11764118 )
2000
29
Angular cheilitis after tonsillectomy. ( 10472460 )
1999
30
Acquired linear anetoderma following angular cheilitis. ( 9666860 )
1998
31
Case 9. Actinic cheilosis. ( 10825898 )
1998
32
Angular cheilitis in HIV-infected patients from Spain: a common Candida-associated oral lesion. ( 11507473 )
1997
33
Clinical, microbiological and ultrastructural features of angular cheilitis lesions in Southern Chinese. ( 7553380 )
1995
34
Angular cheilitis: a case for the oral physician? ( 8941789 )
1995
35
Case #5. Angular cheilitis. ( 1410625 )
1992
36
Angular cheilitis in a group of Sri Lankan adults: a clinical and microbiologic study. ( 2061855 )
1991
37
Oral medicine in practice: angular cheilitis. ( 2069827 )
1991
38
Phenotypic characterization of mononuclear cells and class II antigen expression in angular cheilitis infected by Candida albicans or Staphylococcus aureus. ( 2468179 )
1989
39
Oral medicine in practice: angular cheilitis. ( 2775569 )
1989
40
'Oral medicine in practice: angular cheilitis'. ( 2610751 )
1989
41
Treatment of angular cheilitis. The significance of microbial analysis, antimicrobial treatment, and interfering factors. ( 3063051 )
1988
42
Recurrence of angular cheilitis. ( 3166200 )
1988
43
Angular cheilitis: a clinical and microbial study. ( 3088236 )
1986
44
Recurrent angular cheilitis caused by dental flossing. ( 3722500 )
1986
45
Collagen implant in management of perlèche (angular cheilosis). ( 3989009 )
1985
46
Penicillamine Induced Cheilosis. ( 28164880 )
1985
47
Antibiotic sensitivity and phage typing of Staphylococcus aureus isolated from non-hospitalized patients with angular cheilitis. ( 6085101 )
1984
48
Angular cheilosis: an analysis of 156 cases. ( 6594458 )
1984
49
Surgical treatment of angular cheilosis. ( 6411634 )
1983
50
Angular cheilitis--a bacterial infection. ( 6955524 )
1982

Variations for Angular Cheilitis

Expression for Angular Cheilitis

Search GEO for disease gene expression data for Angular Cheilitis.

Pathways for Angular Cheilitis

Pathways related to Angular Cheilitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 GFPT1 MBTPS2
2 11.73 CDKN2C MEN1
3
Show member pathways
11.61 GFPT1 GFPT2
4 11.53 CDKN2C MEN1
5
Show member pathways
11.2 GFPT1 GFPT2
6
Show member pathways
10.84 GFPT1 GFPT2
7 10.18 GFPT1 GFPT2

GO Terms for Angular Cheilitis

Biological processes related to Angular Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-linked glycosylation GO:0006487 9.46 GFPT1 GFPT2
2 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.43 CDKN2C MEN1
3 glutamine metabolic process GO:0006541 9.4 GFPT1 GFPT2
4 energy reserve metabolic process GO:0006112 9.37 GFPT1 GFPT2
5 UDP-N-acetylglucosamine biosynthetic process GO:0006048 9.32 GFPT1 GFPT2
6 fructose 6-phosphate metabolic process GO:0006002 9.26 GFPT1 GFPT2
7 UDP-N-acetylglucosamine metabolic process GO:0006047 9.16 GFPT1 GFPT2
8 carbohydrate derivative metabolic process GO:1901135 8.96 GFPT1 GFPT2
9 carbohydrate derivative biosynthetic process GO:1901137 8.62 GFPT1 GFPT2

Molecular functions related to Angular Cheilitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transaminase activity GO:0008483 9.16 GFPT1 GFPT2
2 carbohydrate derivative binding GO:0097367 8.96 GFPT1 GFPT2
3 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GO:0004360 8.62 GFPT1 GFPT2

Sources for Angular Cheilitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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