Anhidrosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ANH002 MIFTS: 45	Anhidrosis Categories: Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Anhidrosis

MalaCards integrated aliases for Anhidrosis:

Name: Anhidrosis ¹² ⁵⁴ ¹⁵ ³⁹ ¹⁷ ⁷⁰ ³²

Hypohidrosis ⁴⁴ ¹⁷ ⁷⁰

Absence of Sweating ¹²

Adiaphoresis ¹²

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the skin and subcutaneous tissue

Disorders of skin appendages

Eccrine sweat disorders

Anhidrosis

External Ids:

Disease Ontology ¹² DOID:11156

ICD9CM ³⁴ 705.0

MeSH ⁴⁴ D007007

NCIt ⁵⁰ C34385

SNOMED-CT ⁶⁷ 201189007

ICD10 ³² L74.4

EFO ¹⁷ EFO_1000670 EFO_1000712

UMLS ⁷⁰ C0003028 C0020620

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Summaries for Anhidrosis

Disease Ontology : ¹² A hypohidrosis that is characterized by the inability to sweat and has symptom hyperthermia and dry skin.

MalaCards based summary : Anhidrosis, also known as hypohidrosis, is related to ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant and ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive, and has symptoms including hyperthermia and increased sweating. An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are GPCR Pathway and PEDF Induced Signaling. Affiliated tissues include skin, spinal cord and pituitary, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : ⁷³ Hypohidrosis is a disorder in which a person exhibits diminished sweating in response to appropriate... more...

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Related Diseases for Anhidrosis

Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)

#	Related Disease	Score	Top Affiliating Genes
1	ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant	30.6	EDARADD EDAR EDA
2	ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	30.6	EDARADD EDAR EDA
3	ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	30.5	EDARADD EDAR EDA
4	ectodermal dysplasia 1, hypohidrotic, x-linked	30.5	EDARADD EDAR EDA
5	cholinergic urticaria	30.5	CHRM3 ACHE
6	neuropathy, hereditary sensory and autonomic, type v	30.4	NTRK1 NGFR NGF
7	ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	30.4	IKBKG EDARADD EDAR EDA
8	prurigo nodularis	30.0	NGFR NGF
9	diabetic neuropathy	29.8	NTRK1 NGFR NGF
10	peripheral nervous system disease	29.7	NTRK3 NTRK1 NGFR NGF ACHE
11	anodontia	29.4	IKBKG EDARADD EDAR EDA
12	incontinentia pigmenti	29.3	IKBKG EDAR EDA
13	ectodermal dysplasia	29.3	ORAI1 IKBKG EDARADD EDAR EDA
14	tooth agenesis	28.9	IKBKG EDARADD EDAR EDA
15	insensitivity to pain, congenital, with anhidrosis	11.8
16	anhidrosis, isolated, with normal sweat glands	11.6
17	ectodermal dysplasia 14, hair/tooth type with or without hypohidrosis	11.4
18	retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome	11.3
19	shaheen syndrome	11.3
20	ectodermal dysplasia 15, hypohidrotic/hair type	11.2
21	witkop syndrome	11.2
22	harlequin syndrome	11.2
23	ameloonychohypohidrotic syndrome	11.2
24	van den bosch syndrome	11.2
25	dermatopathia pigmentosa reticularis	11.1
26	hypohidrosis with abnormal palmar dermal ridges	11.1
27	ntrk1 congenital insensitivity to pain with anhidrosis	11.1
28	horner's syndrome	11.0
29	bazex syndrome	11.0
30	naegeli-franceschetti-jadassohn syndrome	11.0
31	poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis	11.0
32	ichthyosis, lamellar, autosomal dominant	11.0
33	ectodermal dysplasia and immunodeficiency 1	11.0
34	hereditary sensory neuropathy	11.0
35	limb-mammary syndrome	11.0
36	lelis syndrome	11.0
37	anhidrosis, familial generalized, with abnormal or absent sweat glands	10.9
38	autosomal recessive congenital ichthyosis	10.9
39	helix syndrome	10.9
40	pain sensitivity quantitative trait locus 1	10.9
41	ankyloblepharon-ectodermal defects-cleft lip/palate	10.8
42	basan syndrome	10.8
43	ectodermal dysplasia, hypohidrotic, with hypothyroidism and ciliary dyskinesia	10.8
44	cleft lip/palate-ectodermal dysplasia syndrome	10.8
45	pigmentary disorder, reticulate, with systemic manifestations, x-linked	10.8
46	immunodeficiency 10	10.8
47	ichthyosis follicularis atrichia photophobia syndrome	10.8
48	naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis	10.8
49	horner syndrome, congenital	10.8
50	ichthyosis, congenital, autosomal recessive 2	10.8

Graphical network of the top 20 diseases related to Anhidrosis:

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Symptoms & Phenotypes for Anhidrosis

Symptoms:

¹²

• hyperthermia

UMLS symptoms related to Anhidrosis:

increased sweating

MGI Mouse Phenotypes related to Anhidrosis:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.32	ACHE CHRM3 CLDN10 COG6 EDARADD GLA
2	growth/size/body region	MP:0005378	10.32	ACHE CHRM3 EDAR EDARADD GLA IKBKG
3	homeostasis/metabolism	MP:0005376	10.28	ACHE CHRM3 CLDN10 COG6 EDARADD GLA
4	cardiovascular system	MP:0005385	10.24	ACHE CHRM3 COG6 EDAR GLA IKBKG
5	mortality/aging	MP:0010768	10.21	ACHE EDAR EDARADD GLA IKBKG INSRR
6	integument	MP:0010771	10.1	COG6 EDAR EDARADD IKBKG ITPR2 MAPK1
7	nervous system	MP:0003631	10	ACHE CHRM3 COG6 EDARADD GLA MAPK1
8	hearing/vestibular/ear	MP:0005377	9.93	ACHE EDARADD MAPK1 NGFR NTRK1 NTRK3
9	muscle	MP:0005369	9.87	ACHE CHRM3 GLA MAPK1 NGF NGFR
10	normal	MP:0002873	9.81	COG6 IKBKG INSRR ITPR2 NGF NGFR
11	vision/eye	MP:0005391	9.4	ACHE CHRM3 COG6 EDAR EDARADD GLA
12	pigmentation	MP:0001186	9.35	COG6 EDAR EDARADD IKBKG NTRK1

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Drugs & Therapeutics for Anhidrosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase II, Randomized, Double Blind, Cross-over, Placebo-controlled Study on Norepinephrine Replenishment Therapy Using L-DOPS in Congenital Insensitivity to Pain With Anhidrosis Patients	Withdrawn	NCT02624310	Phase 2	Droxidopa (L-DOPS);Placebo

Search NIH Clinical Center for Anhidrosis

Cochrane evidence based reviews: hypohidrosis

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Genetic Tests for Anhidrosis

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Anatomical Context for Anhidrosis

MalaCards organs/tissues related to Anhidrosis:

⁴⁰

Skin, Spinal Cord, Pituitary, Thyroid, Kidney, Breast, Tongue

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Publications for Anhidrosis

Articles related to Anhidrosis:

(show top 50) (show all 1333)

#	Title	Authors	PMID	Year
1	Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation. ⁵⁴ ⁶¹	Rotthier A...Timmerman V	19651702	2009
2	Nerve growth factor, interoception, and sympathetic neuron: lesson from congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Indo Y	19201660	2009
3	Two novel mutations in the ED1 gene in Japanese families with X-linked hypohidrotic ectodermal dysplasia. ⁵⁴ ⁶¹	Gunadi...Nishio H	19127222	2009
4	Humoral immunodeficiency in congenital insensitivity to pain with anhidrosis. ⁶¹ ⁵⁴	Kilic SS...Timmerman V	19089473	2009
5	Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene. ⁶¹ ⁵⁴	Suriu C...Falik-Zaccai TC	19250380	2009
6	Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. ⁶¹ ⁵⁴	Beigelman A...Levy R	18955016	2009
7	Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. ⁶¹ ⁵⁴	Huehne K...Rautenstrauss B	18077166	2008
8	Decreased first phase insulin response in children with congenital insensitivity to pain with anhidrosis. ⁶¹ ⁵⁴	Schreiber R...Hershkovitz E	16279365	2005
9	Congenital insensitivity to pain with Anhidrosis (NTRK1 mutation) and early onset renal disease: clinical report on three sibs with a 25-year follow-up in one of them. ⁵⁴ ⁶¹	Barone R...Pavone P	16138253	2005
10	Familial insensitivity to pain (HSAN V) and a mutation in the NGFB gene. A neurophysiological and pathological study. ⁵⁴ ⁶¹	Minde J...Solders G	15468048	2004
11	A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA). ⁵⁴ ⁶¹	Melamed I...Gelfand EW	15163901	2004
12	Anti-apoptotic effect of nerve growth factor is lost in congenital insensitivity to pain with anhidrosis (CIPA) B lymphocytes. ⁵⁴ ⁶¹	Sato Y...Eguchi M	15114061	2004
13	The anaesthetic management of patients with congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Rozentsveig V...Gurman GM	15078381	2004
14	Neurotrophic factors and their receptors in human sensory neuropathies. ⁵⁴ ⁶¹	Anand P	14699981	2004
15	An infant with primary tooth loss and palmar hyperkeratosis: a novel mutation in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Bonkowsky JL...Swoboda KJ	12949319	2003
16	RET and NTRK1 proto-oncogenes in human diseases. ⁵⁴ ⁶¹	Alberti L...Pierotti MA	12652644	2003
17	Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. ⁶¹ ⁵⁴	Indo Y	11748840	2001
18	Neurophysiologic studies in congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Shorer Z...Levy J	11744315	2001
19	Congenital insensitivity to pain with anhidrosis (CIPA): novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency. ⁶¹ ⁵⁴	Indo Y...Matsuda I	11668614	2001
20	Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. ⁶¹ ⁵⁴	Mardy S...Indo Y	11159935	2001
21	Two novel mutant alleles of the gene encoding neurotrophic tyrosine kinase receptor type 1 (NTRK1) in a patient with congenital insensitivity to pain with anhidrosis: a splice junction mutation in intron 5 and cluster of four mutations in exon 15. ⁵⁴ ⁶¹	Bodzioch M...Schmitz G	11139246	2001
22	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis. ⁶¹ ⁵⁴	Miura Y...Indo Y	11071380	2000
23	Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. ⁵⁴ ⁶¹	Miura Y...Indo Y	10982191	2000
24	The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. ⁶¹ ⁵⁴	Greco A...Pierotti MA	10567924	2000
25	Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. ⁵⁴ ⁶¹	Mardy S...Indo Y	10330344	1999
26	A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis. ⁶¹ ⁵⁴	Yotsumoto S...Kanzaki T	10233776	1999
27	A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Greco A...Pierotti MA	10090906	1999
28	Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor. ⁶¹ ⁵⁴	Indo Y...Matsuda I	9290260	1997
29	Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. ⁵⁴ ⁶¹	Indo Y...Matsuda I	8696348	1996
30	Possible mechanism of anhidrosis in a symptomatic female carrier of Fabry's disease: an assessment by skin sympathetic nerve activity and sympathetic skin response. ⁵⁴ ⁶¹	Yamamoto K...Mano T	8726095	1996
31	New mutation in Fabry disease: c.448delG, first phenotypic description. ⁶¹	Calabrese E...Rosenfeld DP	33732617	2021
32	[Clinical features and enzyme replacement therapy in 4 children with Fabry disease]. ⁶¹	Lu ZH...Mao JH	33775053	2021
33	Disorder of sex development associated with a novel homozygous nonsense mutation in COG6 expands the phenotypic spectrum of COG6-CDG. ⁶¹	Lugli L...Berardi A	33394555	2021
34	Clear cell injury associated with reduced expression of carbonic anhydrase II in eccrine glands consistently occurs in patients with acquired idiopathic generalized anhidrosis. ⁶¹	Sano K...Okuyama R	33454997	2021
35	High thoracic ossification of ligamentum flavum causing partial Horner syndrome. ⁶¹	Kim DH...Son DW	29490510	2021
36	Prognosis after steroid pulse therapy and seasonal effect in acquired idiopathic generalized anhidrosis. ⁶¹	Iida T...Yokozeki H	33146891	2021
37	A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. ⁶¹	Alzahrani AS...Dasouki M	33675844	2021
38	Reduced Myocardial Uptake of 123I-MIBG in Congenital Insensitivity to Pain With Anhidrosis. ⁶¹	Sasahara M...Harada M	33351513	2021
39	Skeletal complications in congenital insensitivity to pain and anhidrosis: a problem to reckon with. ⁶¹	Tandon V...Sundaram S	33738666	2021
40	Variable clinical features of patients with Fabry disease and outcome of enzyme replacement therapy. ⁶¹	Dutra-Clarke M...Kimonis V	33437642	2021
41	High incidence of adnexotropism in cytotoxic cutaneous lymphomas. ⁶¹	Walker CJ...Guitart J	33759218	2021
42	Ocular manifestations of congenital insensitivity to pain: a long-term follow-up. ⁶¹	Elsana B...Tsumi E	33753408	2021
43	Hypohidrosis in the macules in tuberous sclerosis complex and neurofibromatosis. ⁶¹	Koguchi-Yoshioka H...Wataya-Kaneda M	33368630	2021
44	Isolated anhidrosis of an upper limb in a patient with lung cancer: "One-sleeve shirt sign". ⁶¹	Fujiwara S...Kawamoto M	33752233	2021
45	[Phenotypic and genetic analysis of a case with hypohidrotic ectodermal dysplasia due to Xq13.1 microdeletion]. ⁶¹	Mei D...Zhang Y	33751528	2021
46	My Treatment Approach to Multiple System Atrophy. ⁶¹	Coon EA...Ahlskog JE	33673922	2021
47	Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. ⁶¹	Cheshire WP...Singer W	33419664	2021
48	No evidence for preferential X-chromosome inactivation as the main cause of divergent phenotypes in sisters with X-linked hypohidrotic ectodermal dysplasia. ⁶¹	Korber L...Maier-Wohlfart S	33622384	2021
49	A classic variant of Fabry disease in a family with the M296I late-onset variant. ⁶¹	Hirashio S...Masaki T	32902816	2021
50	Ectodermal Dysplasia Presenting as Heat Exhaustion in an Adolescent Boy. ⁶¹	Guntreddi G...Nirujogi SP	33767934	2021

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Genes for Anhidrosis

Genes related to Anhidrosis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	58.76	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	12949319 16138253 11139246 (more) 11159935 10233776 19250380 9290260 16279365 10090906 19201660 11748840 8696348 15114061 14699981 19651702 19089473 11744315 11071380 10330344 15163901 10982191 18955016 12652644 11668614 15078381 18077166
2	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	30.96	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries Variants (show sections)
3	COG6	Component Of Oligomeric Golgi Complex 6	Protein Coding	29.28	Likely pathogenic ⁶ DISEASES inferred ¹⁵
4	NGF	Nerve Growth Factor	Protein Coding	23.51	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16138253 18955016 10567924 (more) 19201660 15114061 8696348 11159935 15468048
5	CLDN10	Claudin 10	Protein Coding	20.88	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
6	EDA	Ectodysplasin A	Protein Coding	17.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	19127222
7	GLA	Galactosidase Alpha	Protein Coding	14.04	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8726095
8	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	12.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	NGFR	Nerve Growth Factor Receptor	Protein Coding	12.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	ORAI1	ORAI Calcium Release-Activated Calcium Modulator 1	Protein Coding	11.75	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
11	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	11.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	11.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	PKLR	Pyruvate Kinase L/R	Protein Coding	10.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	UGGT2	UDP-Glucose Glycoprotein Glucosyltransferase 2	Protein Coding	10.09	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	INSRR	Insulin Receptor Related Receptor	Protein Coding	7.44	GeneCards inferred via : Variants (show sections)
16	EDARADD	EDAR Associated Death Domain	Protein Coding	7.35	DISEASES inferred ¹⁵
17	EDAR	Ectodysplasin A Receptor	Protein Coding	7.15	DISEASES inferred ¹⁵
18	ACHE	Acetylcholinesterase (Cartwright Blood Group)	Protein Coding	6.45	GeneCards inferred via : Publications (show sections)
19	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	6.45	GeneCards inferred via : Publications (show sections)

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Variations for Anhidrosis

ClinVar genetic disease variations for Anhidrosis:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	COG6	NM_020751.3(COG6):c.1167-24A>G	SNV	Likely pathogenic	183333	rs730882236	GRCh37: 13:40273614-40273614 GRCh38: 13:39699477-39699477

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Expression for Anhidrosis

Search GEO for disease gene expression data for Anhidrosis.

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Pathways for Anhidrosis

Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 38)

#	Super pathways	Score	Top Affiliating Genes
1	GPCR Pathway ⁶³ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶³ Estrogen Pathway ⁶³ NFAT in Immune Response ⁶³ P2Y Receptor Signaling ⁶³ Pancreatic Adenocarcinoma ⁶³ Paxillin Interactions ⁶³ Ras Pathway ⁶³	13.62	NTRK3 NTRK1 NGFR NGF MAPK1 ITPR2
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.53	NTRK3 NTRK1 NGFR NGF MAPK1 INSRR
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.44	NTRK3 NTRK1 NGFR NGF MAPK1 ITPR2
4	Nanog in Mammalian ESC Pluripotency ⁶³ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶³ eNOS Signaling ⁶³ GSK3 Signaling ⁶³	13.2	NTRK3 NTRK1 NGF MAPK1 ITPR2 INSRR
5	CREB Pathway ⁶³ Show member pathways Activation of PKC through GPCR ⁶³ Intracellular Calcium Signaling ⁶³ IP3 Pathway ⁶³	13.19	NTRK3 NTRK1 NGFR NGF MAPK1 ITPR2
6	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	12.95	NTRK3 NTRK1 NGFR NGF MAPK1 ITPR2
7	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	12.91	NTRK1 NGFR NGF MAPK1 IKBKG
8	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	12.86	NTRK3 NTRK1 NGFR NGF MAPK1 ITPR2
9	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.78	NTRK3 NTRK1 MAPK1 ITPR2 IKBKG
10	MAPK signaling pathway ³⁶ ¹	12.66	NTRK1 NGFR NGF MAPK1 IKBKG
11	Ras signaling pathway ³⁶ Show member pathways Rap1 signaling pathway ³⁶	12.6	NTRK1 NGFR NGF MAPK1 IKBKG
12	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.58	NTRK3 NTRK1 NGFR NGF MAPK1
13	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.54	NTRK1 NGF MAPK1 ITPR2
14	Neuroscience ⁴	12.5	NTRK3 NTRK1 NGFR NGF
15	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²³ Apoptosis Signaling Pathways ⁶⁴	12.5	NTRK1 NGFR NGF MAPK1 ITPR2 IKBKG
16	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²³ Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²³ Cell adhesion Tight junctions ²³ Cytoskeleton remodeling Integrin outside-in signaling ²³ Development MAG-dependent inhibition of neurite outgrowth ²³	12.43	NTRK3 NTRK1 NGFR NGF MAPK1
17	Apoptosis Pathway ⁶⁹ Show member pathways Akt Pathway ⁶⁹ NF-kappaB Pathway ⁶⁹	12.36	NTRK3 NTRK1 NGFR IKBKG
18	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.31	NTRK3 NTRK1 NGF MAPK1 INSRR
19	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.23	NGFR NGF MAPK1 ITPR2 IKBKG EDAR
20	Calcium signaling pathway ³⁶	12.18	ORAI1 NTRK3 NTRK1 NGF ITPR2 CHRM3
21	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.17	NTRK3 NTRK1 NGFR NGF
22	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	12.14	NTRK3 NTRK1 MAPK1 INSRR
23	NGF Pathway ⁶³ Show member pathways TRKA Signaling ⁶³	11.95	NTRK1 NGFR NGF MAPK1 IKBKG
24	Platelet activation ³⁶	11.94	ORAI1 MAPK1 ITPR2
25	Guidance Cues and Growth Cone Motility ⁶³	11.86	NTRK3 NTRK1 NGFR NGF
26	NF-kappa B signaling pathway ³⁶	11.77	IKBKG EDARADD EDAR EDA
27	Endocytic Trafficking of EGFR ⁶³ Show member pathways Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF) ²³ Recycling pathway of L1 ⁶⁵ Retrograde neurotrophin signalling ⁶⁵	11.69	NTRK1 NGF MAPK1
28	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.66	NGFR NGF IKBKG
29	Central carbon metabolism in cancer ³⁶	11.63	NTRK3 NTRK1 MAPK1
30	G-protein signaling_RhoA regulation pathway ²³	11.6	NTRK3 NTRK1 NGF MAPK1 ITPR2
31	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁵ NFG and proNGF binds to p75NTR ⁶⁵	11.58	NGFR NGF IKBKG
32	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.57	NGFR NGF EDARADD EDAR EDA
33	Alzheimers Disease Pathway ⁶³	11.35	NTRK3 NTRK1 MAPK1
34	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.26	NTRK3 NTRK1 NGFR NGF MAPK1 IKBKG
35	Neurotrophic factor-mediated Trk receptor signaling ¹ Show member pathways Signalling to STAT3 ⁶⁵ TRKA activation by NGF ⁶⁵	11.14	NTRK3 NTRK1 NGFR NGF MAPK1
36	G-protein signaling_Rap2B regulation pathway ²³	10.94	NTRK3 NTRK1 NGF MAPK1 INSRR
37	MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ ¹	10.72	MAPK1 IKBKG
38	Activation of TRKA receptors ⁶⁵ Show member pathways NGF-independant TRKA activation ⁶⁵	10.67	NTRK1 NGF

Sources

GO Terms for Anhidrosis

Cellular components related to Anhidrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.7	ORAI1 NTRK3 NTRK1 NGFR INSRR EDA
2	receptor complex	GO:0043235	9.26	NTRK3 NTRK1 ITPR2 INSRR
3	axon	GO:0030424	9.02	NTRK3 NTRK1 NGF MAPK1 INSRR

Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	10.01	NTRK3 NTRK1 NGFR EDARADD EDAR EDA
2	multicellular organism development	GO:0007275	9.91	NTRK3 NTRK1 NGFR INSRR EDARADD EDAR
3	nervous system development	GO:0007399	9.89	NTRK3 NTRK1 NGFR CHRM3 ACHE
4	positive regulation of gene expression	GO:0010628	9.85	NTRK3 NGF MAPK1 EDAR EDA
5	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.74	EDARADD EDAR EDA
6	positive regulation of kinase activity	GO:0033674	9.61	NTRK3 NTRK1 INSRR
7	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.58	EDARADD EDAR EDA
8	regulation of protein kinase B signaling	GO:0051896	9.56	NTRK3 NTRK1
9	nerve development	GO:0021675	9.55	NGFR NGF
10	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043281	9.52	NGFR NGF
11	nerve growth factor signaling pathway	GO:0038180	9.51	NTRK1 NGF
12	acetylcholine receptor signaling pathway	GO:0095500	9.48	CHRM3 ACHE
13	activation of MAPKK activity	GO:0000186	9.43	NTRK1 NGF MAPK1
14	salivary gland cavitation	GO:0060662	9.32	EDAR EDA
15	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.26	NTRK3 NTRK1 NGF INSRR
16	neurotrophin signaling pathway	GO:0038179	9.16	NTRK3 NTRK1
17	neurotrophin TRK receptor signaling pathway	GO:0048011	8.8	NTRK1 NGFR NGF

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.36	UGGT2 PKLR ORAI1 NTRK3 NTRK1 NGFR
2	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.43	NTRK3 NTRK1 INSRR
3	acetylcholine binding	GO:0042166	9.37	CHRM3 ACHE
4	GPI-linked ephrin receptor activity	GO:0005004	9.32	NTRK3 NTRK1
5	nerve growth factor binding	GO:0048406	9.16	NTRK1 NGFR
6	neurotrophin receptor activity	GO:0005030	8.96	NTRK3 NTRK1
7	neurotrophin binding	GO:0043121	8.8	NTRK3 NTRK1 NGFR

Sources

Sources for Anhidrosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia