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MCID: ANH002
MIFTS: 48

Anhidrosis

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anhidrosis

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MalaCards integrated aliases for Anhidrosis:

Name: Anhidrosis 12 29 55 15 40 73
Absence of Sweating 12
Adiaphoresis 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11156
ICD10 33 L74.4
ICD9CM 35 705.0
MeSH 44 D007007
NCIt 50 C34385
SNOMED-CT 68 14662005 39659002
UMLS 73 C0003028
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Summaries for Anhidrosis

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MalaCards based summary : Anhidrosis, also known as absence of sweating, is related to hereditary sensory neuropathy and neuropathy, hereditary sensory and autonomic, type v, and has symptoms including increased sweating An important gene associated with Anhidrosis is NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1), and among its related pathways/superpathways are TGF-Beta Pathway and Phospholipase-C Pathway. The drugs Vasoconstrictor Agents and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Hypohidrosis is diminished sweating in response to appropriate stimuli. In contrast with hyperhidrosis... more...

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Related Diseases for Anhidrosis

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Diseases related to Anhidrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 hereditary sensory neuropathy 32.1 NGF NTRK1
2 neuropathy, hereditary sensory and autonomic, type v 31.2 NGF NGFR NTRK1
3 autonomic neuropathy 30.2 NGF NTRK1
4 insensitivity to pain, congenital, with anhidrosis 12.7
5 anhidrosis, isolated, with normal sweat glands 12.4
6 anhidrosis, familial generalized, with abnormal or absent sweat glands 12.0
7 harlequin syndrome 11.6
8 van den bosch syndrome 11.6
9 hypohidrosis 11.5
10 horner's syndrome 11.3
11 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 11.2
12 ectodermal dysplasia 1, hypohidrotic, x-linked 11.2
13 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.9
14 horner syndrome, congenital 10.9
15 neuropathy, hereditary sensory and autonomic, type iia 10.9
16 ichthyosis, congenital, autosomal recessive 2 10.9
17 ichthyosis, congenital, autosomal recessive 1 10.9
18 ichthyosis, congenital, autosomal recessive 4a 10.9
19 ichthyosis, congenital, autosomal recessive 11 10.9
20 ichthyosis, congenital, autosomal recessive 5 10.9
21 ichthyosis, congenital, autosomal recessive 3 10.9
22 ichthyosis, congenital, autosomal recessive 6 10.9
23 immunodeficiency 9 10.9
24 ichthyosis, congenital, autosomal recessive 8 10.9
25 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.9
26 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.9
27 splenomegaly, cytopenia, and vision loss 10.9
28 ichthyosis, congenital, autosomal recessive 7 10.9
29 ichthyosis, congenital, autosomal recessive 9 10.9
30 ichthyosis, congenital, autosomal recessive 10 10.9
31 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
32 helix syndrome 10.9
33 ectodermal dysplasia, hypohidrotic, with immune deficiency 10.9
34 neuropathy 10.5
35 sensory peripheral neuropathy 10.4
36 alopecia 10.2
37 ectodermal dysplasia 10.2
38 miliaria 10.2
39 askin's tumor 10.1 NGF NTRK1
40 prolactin producing pituitary tumor 10.1 NGF NTRK1
41 conjunctival nevus 10.1 NGF NTRK1
42 causalgia 10.1 NGF NTRK1
43 ocular cicatricial pemphigoid 10.1 NGF NTRK1
44 cerebral cavernous malformations 2 10.1 NGF NTRK1
45 autonomic nervous system neoplasm 10.1 NGF NTRK1
46 peripheral nervous system neoplasm 10.1 NGF NTRK1
47 multiple system atrophy 1 10.0
48 cholinergic urticaria 10.0
49 urticaria 10.0
50 dermatitis 10.0

Graphical network of the top 20 diseases related to Anhidrosis:



Diseases related to Anhidrosis
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Symptoms & Phenotypes for Anhidrosis

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UMLS symptoms related to Anhidrosis:


increased sweating

MGI Mouse Phenotypes related to Anhidrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.01 CHRM3 CLDN10 GLA IKBKG ITPR2 NGF
2 growth/size/body region MP:0005378 9.92 CHRM3 GLA IKBKG ITPR2 NGF NGFR
3 homeostasis/metabolism MP:0005376 9.86 CHRM3 CLDN10 GLA IKBKG ITPR2 NGF
4 cardiovascular system MP:0005385 9.85 CHRM3 GLA IKBKG ITPR2 NGF NGFR
5 integument MP:0010771 9.63 IKBKG ITPR2 NGF NGFR NTRK1 ORAI1
6 muscle MP:0005369 9.35 CHRM3 GLA NGF NGFR NTRK1
7 vision/eye MP:0005391 9.1 CHRM3 GLA NGF NGFR NTRK1 ORAI1
Sources

Drugs & Therapeutics for Anhidrosis

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Drugs for Anhidrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vasoconstrictor Agents Phase 2
2 Peripheral Nervous System Agents Phase 2,Not Applicable
3 Neurotransmitter Agents Phase 2,Not Applicable
4
Povidone Approved 9003-39-8
5
Mepivacaine Approved, Vet_approved ,Not Applicable 96-88-8 4062
6
Ropivacaine Approved 84057-95-4 175805 71273
7
Acetylcholine Approved Not Applicable 51-84-3 187
8
Ethanol Approved Not Applicable 64-17-5 702
9
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
10
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
11
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
12 Antihypertensive Agents
13 Anesthetics, Local Not Applicable
14 Anesthetics Not Applicable
15 Anesthetics, Dissociative Not Applicable
16 Analgesics Not Applicable
17 Adjuvants, Anesthesia Not Applicable
18 Excitatory Amino Acids Not Applicable
19 Diuretics, Potassium Sparing Not Applicable
20 GABA Agents Not Applicable
21 Excitatory Amino Acid Antagonists Not Applicable
22 Central Nervous System Depressants Not Applicable
23 Anesthetics, General Not Applicable
24 Sodium Channel Blockers Not Applicable
25 Anesthetics, Intravenous Not Applicable
26 Tranquilizing Agents Not Applicable
27 Psychotropic Drugs Not Applicable
28 Anti-Anxiety Agents Not Applicable
29 Hypnotics and Sedatives Not Applicable
30 GABA Modulators Not Applicable
31 Anti-Arrhythmia Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
2 Analysis of the Sweat Response According to the Pathology in Neurologic Patients Completed NCT03639909
3 Role of Indicator Test (Neuropad) in Detecting Diabetic Neuropathy Completed NCT00895440
4 Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery Completed NCT01926561
5 Clinical Efficacy of Supraclavicular Block for Arthroscopic Shoulder Surgery Completed NCT01958801 Not Applicable
6 Assessment of Small Fiber Neuropathy in Rare Diseases Using Sudoscan Recruiting NCT02985710 Not Applicable
7 Interscalene Nerve Block vs. Sedation for Shoulder Dislocation Reduction Not yet recruiting NCT03041506 Not Applicable Lidocaine;Midazolam;Ketamine

Search NIH Clinical Center for Anhidrosis

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Genetic Tests for Anhidrosis

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Genetic tests related to Anhidrosis:

# Genetic test Affiliating Genes
1 Anhidrosis 29
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Anatomical Context for Anhidrosis

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MalaCards organs/tissues related to Anhidrosis:

41
Skin, Eye, Testes, Lung, Bone, Spinal Cord, Pituitary
Sources

Publications for Anhidrosis

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Articles related to Anhidrosis:

(show top 50) (show all 333)
# Title Authors Year
1
Hemodynamic Response to Massive Bleeding in a Patient with Congenital Insensitivity to Pain with Anhidrosis. ( 29971168 )
2018
2
Successful treatment of chronic intractable pain with risperidone in a patient with acquired idiopathic generalized anhidrosis. ( 29446147 )
2018
3
Phenotypic heterogeneity of intellectual disability in patients with congenital insensitivity to pain with anhidrosis: A case report and literature review. ( 29619836 )
2018
4
Novel NTRK1 mutations in Chinese patients with congenital insensitivity to pain with anhidrosis. ( 29770739 )
2018
5
Acquired idiopathic generalised anhidrosis: A rare cause of sweating deficiency. ( 29732530 )
2018
6
NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. ( 29407522 )
2018
7
Acquired idiopathic generalized anhidrosis in a young Austrian patient. ( 29687054 )
2018
8
A Case of Congenital Insensitivity to Pain With Anhidrosis Comorbid With Attention Deficit Hyperactivity Disorder: Clinical Implications for Pathophysiology and Treatment. ( 29595626 )
2018
9
Congenital Loss of Permanent Teeth in a Patient With Congenital Insensitivity to Pain With Anhidrosis due to 2 Novel Mutations in the NTRK1 Gene. ( 30075136 )
2018
10
Identification of a novel mutation of the NTRK1 gene in patients with congenital insensitivity to pain with anhidrosis (CIPA). ( 30201336 )
2018
11
Generalized anhidrosis as first clinical presentation of systemic lupus erythematosus. ( 30282559 )
2018
12
Case of generalized anhidrosis associated with diffuse reticular hyperpigmentation and syndactyly. ( 30447014 )
2018
13
Phenotypic and genotypic features of a pair of Chinese identical twins with congenital insensitivity to pain and anhidrosis: A case report. ( 30461622 )
2018
14
Postoperative redislocation of the hip in a patient with congenital insensitivity to pain with anhidrosis: A case report and review of literature. ( 30510952 )
2018
15
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. ( 28686597 )
2017
16
The relevance of anhidrosis in Horner syndrome: Analysis of an image. ( 29277520 )
2017
17
Could Congenital Insensitivity to Pain with Anhidrosis Be Misdiagnosed as Papillon-LefA"vre Syndrome? ( 29142767 )
2017
18
Novel NTRK1 mutations associated with congenital insensitivity to pain with anhidrosis verified by functional studies. ( 28177573 )
2017
19
Case of autoimmune autonomic ganglionopathy manifesting anhidrosis. ( 28620980 )
2017
20
Observation of water evaporation and stratum corneum hydration and pH during the clinical course of a patient with acquired idiopathic generalized anhidrosis. ( 28677824 )
2017
21
[Mutation analysis of NTRK1 gene in a family affected with congenital insensitivity to pain with anhidrosis]. ( 28981924 )
2017
22
Anesthetic management during adenotonsillectomy for twins with congenital insensitivity to pain with anhidrosis: two case reports. ( 28838318 )
2017
23
Idiopathic segmental anhidrosis. ( 28541441 )
2017
24
An Innovative Cooling Jacket to Combat Heat Intolerance in Children with Anhidrosis. ( 28429544 )
2017
25
Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case. ( 29142185 )
2017
26
Degranulation and shrinkage of dark cells in eccrine glands and elevated serum carcinoembryonic antigen in patients with acquired idiopathic generalized anhidrosis. ( 28662305 )
2017
27
Identification of a novel nonsense mutation of the neurotrophic tyrosine kinase receptor type 1 gene in two siblings with congenital insensitivity to pain with anhidrosis. ( 28345382 )
2017
28
Skin Ultrastructural Findings in Acquired Generalized Hypohidrosis/Anhidrosis in a Patient with Subclinical SjAPgren Syndrome. ( 28448095 )
2017
29
Acquired anhidrosis associated with systemic sarcoidosis: Quantification of nerve fibers around eccrine glands by confocal microscopy. ( 28796884 )
2017
30
Prognosis of acquired idiopathic generalized anhidrosis. ( 28771990 )
2017
31
Recurrent and novel mutations in the NTRK1 gene lead to rare congenital insensitivity to pain with anhidrosis in two Chinese patients. ( 28192073 )
2017
32
Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores. ( 28328088 )
2017
33
Unilateral facial and upper truncal anhidrosis and absence of physiological flushing: A case of idiopathic harlequin syndrome. ( 28799533 )
2017
34
Total Hip Arthroplasty in an Inveterate Femoral Neck Fracture in a Patient with Congenital Insensitivity to Pain with Anhidrosis. ( 29270564 )
2017
35
Idiopathic segmental anhidrosis associated with varicella. ( 27206820 )
2016
36
Purple hands in multiple system atrophy: Global anhidrosis with preserved acral sweating. ( 27298449 )
2016
37
A Girl with No Pain: Congenital Insensitivity To Pain and Anhidrosis (HSAN) Type IV - A Case Report. ( 27042602 )
2016
38
Congenital Insensitivity to Pain and Anhidrosis. ( 26848454 )
2016
39
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. ( 26902244 )
2016
40
Harlequin syndrome with contralateral anhidrosis after an upper chest gunshot wound. ( 27535737 )
2016
41
Revised guideline for the diagnosis and treatment of acquired idiopathic generalized anhidrosis in Japan. ( 27774633 )
2016
42
Phenotypes and Genotypes in Five Children with Congenital Insensitivity to Pain with Anhidrosis. ( 27265460 )
2016
43
Generalised Anhidrosis Secondary to Intracranial Haemorrhage. ( 27125348 )
2016
44
Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction. ( 27859565 )
2016
45
Orthopaedic manifestations of congenital indifference to pain with anhidrosis (Hereditary Sensory and Autonomic Neuropathy type IV). ( 27637569 )
2016
46
Anesthetic considerations in a parturient with congenital insensitivity to pain with anhidrosis. ( 27884666 )
2016
47
Acquired anhidrosis in a case of autoimmune autonomic ganglionopathy. ( 27774700 )
2016
48
Mutations in TrkA causing congenital insensitivity to pain with anhidrosis (CIPA) induce misfolding, aggregation and mutation-dependent neurodegeneration by dysfunction of the autophagic flux. ( 27551041 )
2016
49
Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis. ( 27584965 )
2016
50
Unilateral anhidrosis: A rare complication of thoracic epidural analgesia. ( 26612960 )
2016
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Variations for Anhidrosis

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Expression for Anhidrosis

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Search GEO for disease gene expression data for Anhidrosis.
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Pathways for Anhidrosis

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Pathways related to Anhidrosis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 64
Show member pathways
 13.25 IKBKG ITPR2 NGF NGFR NTRK1
2
Phospholipase-C Pathway 64
Show member pathways
 12.78 ITPR2 NGF NGFR NTRK1
3
PI3K-Akt signaling pathway 37
Show member pathways
 12.7 IKBKG NGF NGFR NTRK1
4
TNFR1 Pathway 64
Show member pathways
 12.68 IKBKG ITPR2 NGF NGFR
5
p70S6K Signaling 64
Show member pathways
 12.68 IKBKG ITPR2 NGF NGFR NTRK1
6
Development Angiotensin activation of ERK 22
Show member pathways
 12.64 IKBKG ITPR2 NGF NGFR
7
MAPK signaling pathway 37 1
12.49 IKBKG NGF NGFR NTRK1
8
Ras signaling pathway 37
Show member pathways
 12.45 IKBKG NGF NGFR NTRK1
9
Development Endothelin-1/EDNRA signaling 22
Show member pathways
 12.37 IKBKG ITPR2 NGF NTRK1
10
Neuroscience 4
12.33 NGF NGFR NTRK1
11
TRAF Pathway 64
Show member pathways
 12.33 IKBKG ITPR2 NGF NGFR
12
Apoptosis Modulation and Signaling 1
Show member pathways
 12.26 IKBKG ITPR2 NGF NGFR NTRK1
13
Apoptosis Pathway 72
Show member pathways
 12.18 IKBKG NGFR NTRK1
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.01 NGF NGFR NTRK1
15
Calcium signaling pathway 37
Show member pathways
 11.98 CHRM3 ITPR2 ORAI1
16
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.82 ITPR2 NGF NGFR
17
Guidance Cues and Growth Cone Motility 64
11.7 NGF NGFR NTRK1
18
G-protein signaling_RhoA regulation pathway 22
11.48 ITPR2 NGF NTRK1
19
Renin secretion 37
11.45 ITPR2 ORAI1
20
NGF Pathway 64
Show member pathways
 11.44 IKBKG NGF NGFR NTRK1
21
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.41 IKBKG NGF NGFR
22
p75(NTR)-mediated signaling 1
Show member pathways
 11.32 IKBKG NGF NGFR
23
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
11.26 NGF NTRK1
24
Neurotrophic factor-mediated Trk receptor signaling 1
Show member pathways
 11.22 NGF NGFR NTRK1
25
Primary immunodeficiency 37
11.14 IKBKG ORAI1
26
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
11.08 IKBKG NGF NGFR NTRK1
27
14-3-3 and Regulation of BAD Activity 64
11.05 NGF NGFR
28
Activation of TRKA receptors 66
Show member pathways
 10.47 NGF NTRK1
Sources

GO Terms for Anhidrosis

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Biological processes related to Anhidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 9.46 IKBKG NTRK1
2 activation of MAPKK activity GO:0000186 9.43 NGF NTRK1
3 phosphatidylinositol-mediated signaling GO:0048015 9.4 NGF NTRK1
4 positive regulation of axonogenesis GO:0050772 9.37 NGF NGFR
5 cellular response to amyloid-beta GO:1904646 9.32 NGFR NTRK1
6 positive regulation of Ras protein signal transduction GO:0046579 9.26 NGF NTRK1
7 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.16 NGF NGFR
8 nerve growth factor signaling pathway GO:0038180 8.96 NGF NTRK1
9 neurotrophin TRK receptor signaling pathway GO:0048011 8.8 NGF NGFR NTRK1

Molecular functions related to Anhidrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nerve growth factor binding GO:0048406 8.96 NGFR NTRK1
2 neurotrophin binding GO:0043121 8.62 NGFR NTRK1
Sources

Sources for Anhidrosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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