MCID: ANS003
MIFTS: 38

Anisakiasis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Anisakiasis

MalaCards integrated aliases for Anisakiasis:

Name: Anisakiasis 12 74 20 58 54 3 44 15 17 71 32
Infection by Anisakis Larva 12 71
Anisakis Infection 20 3
Pseudoterranova Infection 20

Characteristics:

Orphanet epidemiological data:

58
anisakiasis
Prevalence: 1-9/100000 (Japan),1-9/1000000 (Worldwide); Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:7033
ICD9CM 34 127.1
MeSH 44 D017129
NCIt 50 C128393
SNOMED-CT 67 442652006
ICD10 32 B81.0
MESH via Orphanet 45 D017129
ICD10 via Orphanet 33 B81.0
UMLS via Orphanet 72 C0162576 C2711591
Orphanet 58 ORPHA1070
UMLS 71 C0162576 C2711266

Summaries for Anisakiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that results in infection located in intestinal mucosa with larvae of the nematodes transmitted by ingestion of raw or poorly cooked saltwater fish, has material basis in Anisakis simplex or has material basis in Pseudoterranova decipiens and has symptom abdominal pain, has symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

MalaCards based summary : Anisakiasis, also known as infection by anisakis larva, is related to toxocariasis and chronic urticaria, and has symptoms including abdominal pain and nausea. An important gene associated with Anisakiasis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Cardiac muscle contraction and Smooth Muscle Contraction. The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include intestinal mucosa, pancreas and colon.

CDC : 3 Anisakiasis, or herring worm disease, is a parasitic disease caused by nematodes (worms) that attach to the wall of the esophagus, stomach, or intestine. The best ways to prevent this disease is to avoid eating raw or undercooked fish or squid.

Wikipedia : 74 Anisakis is a genus of parasitic nematodes that have life cycles involving fish and marine mammals. They... more...

Related Diseases for Anisakiasis

Diseases related to Anisakiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 toxocariasis 30.1 TES RNASE3 IGHE
2 chronic urticaria 29.9 RNASE3 IGHE
3 parasitic helminthiasis infectious disease 29.6 TES RNASE3
4 intestinal obstruction 10.4
5 urticaria 10.4
6 appendicitis 10.4
7 childhood-onset asthma 10.3 RNASE3 IGHE
8 exercise-induced anaphylaxis 10.3 IGHE CD79A
9 atopic keratoconjunctivitis 10.3 RNASE3 IGHE
10 immunoglobulin g deficiency 10.3 IGHE CD79A
11 chronic asthma 10.3 RNASE3 IGHE
12 ocular toxoplasmosis 10.3 IGHE CD79A
13 cough variant asthma 10.3 RNASE3 IGHE
14 hypereosinophilic syndrome 10.3
15 vernal conjunctivitis 10.3 RNASE3 IGHE
16 kimura disease 10.3 RNASE3 IGHE
17 vernal keratoconjunctivitis 10.3 RNASE3 IGHE
18 intrinsic asthma 10.2 RNASE3 IGHE
19 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
20 ileitis 10.2
21 gastric ulcer 10.2
22 angioedema 10.2
23 ileus 10.2
24 chronic conjunctivitis 10.2 RNASE3 IGHE
25 clonorchiasis 10.2 IGHE CD79A
26 urinary schistosomiasis 10.2 RNASE3 IGHE
27 latex allergy 10.2 RNASE3 IGHE
28 ocular cicatricial pemphigoid 10.2 RNASE3 CD79A
29 intussusception 10.2
30 peritonitis 10.2
31 pollen allergy 10.2 RNASE3 IGHE
32 henoch-schoenlein purpura 10.2 RNASE3 CD79A
33 respiratory allergy 10.2 RNASE3 IGHE
34 ige responsiveness, atopic 10.2 RNASE3 IGHE
35 onchocerciasis 10.1 RNASE3 IGHE
36 baylisascariasis 10.1 MT-CO2 CD79A
37 milk allergy 10.1 RNASE3 IGHE CD79A
38 otitis media 10.1 RNASE3 IGHE CD79A
39 immunodeficiency with hyper-igm, type 1 10.1 IGHE CD79A
40 paragonimiasis 10.1 TES RNASE3 IGHE
41 strongyloidiasis 10.1 TES IGHE CD79A
42 exanthem 10.1
43 food allergy 10.1
44 gastritis 10.1
45 syphilis 10.1 IGHE CD79A
46 allergic conjunctivitis 10.1 RNASE3 IGHE
47 gastroenteritis 10.0
48 gastroesophageal reflux 9.9
49 neuronal intranuclear inclusion disease 9.9
50 endometrial cancer 9.9

Graphical network of the top 20 diseases related to Anisakiasis:



Diseases related to Anisakiasis

Symptoms & Phenotypes for Anisakiasis

Symptoms:

12
  • abdominal pain
  • nausea

Drugs & Therapeutics for Anisakiasis

Drugs for Anisakiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Role of Anisakidae and/or Fish Flesh Antigens in Fish Allergies. Completed NCT02666092
2 Protists and Nematodes Fish Parasites: From Their Circulation in Ecosystems to Their Impact on Human Health - Prevalence of Fish Allergy in Occupational Settings. Completed NCT02661074

Search NIH Clinical Center for Anisakiasis

Cochrane evidence based reviews: anisakiasis

Genetic Tests for Anisakiasis

Anatomical Context for Anisakiasis

The Foundational Model of Anatomy Ontology organs/tissues related to Anisakiasis:

19
Intestinal Mucosa

MalaCards organs/tissues related to Anisakiasis:

40
Pancreas, Colon, Small Intestine, Lymph Node, Thymus

Publications for Anisakiasis

Articles related to Anisakiasis:

(show top 50) (show all 656)
# Title Authors PMID Year
1
Novel sequences and epitopes of diagnostic value derived from the Anisakis simplex Ani s 7 major allergen. 61 54
18186812 2008
2
Measurement of serum levels of eosinophil cationic protein in the diagnosis of acute gastrointestinal anisakiasis. 61 54
12848764 2003
3
Specific IgE determination to Ani s 1, a major allergen from Anisakis simplex, is a useful tool for diagnosis. 61 54
12141725 2002
4
Serum CD23 is not altered in gastroallergic anisakiasis, but correlates with the production of specific IgE and the amount of polyclonal stimulation. 54 61
11576082 2001
5
Immunoblot analysis of serum IgG, IgA and IgE responses against larval excretory-secretory antigens of Anisakis simplex in patients with gastric anisakiasis. 54 61
2283472 1990
6
Anisakis Allergy: Is Aquacultured Fish a Safe and Alternative Food to Wild-Capture Fisheries for Anisakis simplex-Sensitized Patients? 61
33540832 2021
7
Anisakis simplex (s.s.) larvae (Nematoda: Anisakidae) hidden in the mantle of European flying squid Todarodes sagittatus (Cephalopoda: Ommastrephidae) in NE Atlantic Ocean: Food safety implications. 61
33340941 2021
8
Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model. 61
32107679 2021
9
Probable association between Anisakis infection in the muscle of skipjack tuna (Katsuwonus pelamis) and human anisakiasis in Tokyo, Japan. 61
33161348 2021
10
Multidisciplinary approach in study of the zoonotic Anisakis larval infection in the blue mackerel (Scomber australasicus) and the largehead hairtail (Trichiurus lepturus) in Northern Taiwan. 61
31182381 2020
11
Correlation of NHR-48 Transcriptional Modulator Expression with Selected CYP Genes' Expression during Thiabendazole Treatment of Anisakis simplex (s.l.)?-An In Vitro Study. 61
33316888 2020
12
The Selection of Reliable Reference Genes for RT-qPCR Analysis of Anisakis simplex Sensu Stricto Gene Expression from Different Developmental Stages. 61
32488545 2020
13
INTESTINAL OBSTRUCTION CAUSED BY ANISAKIS. 61
33244980 2020
14
Investigation of Anisakis larvae in different products of ready-to-eat fish meat and imported frozen fish in Turkey. 61
32836093 2020
15
World-wide prevalence of Anisakis larvae in fish and its relationship to human allergic anisakiasis: a systematic review. 61
33025215 2020
16
Anisakis spp. Larvae in Deboned, in-Oil Fillets Made of Anchovies (Engraulis encrasicolus) and Sardines (Sardina pilchardus) Sold in EU Retailers. 61
33027930 2020
17
Anisakiasis and Anisakis: An underdiagnosed emerging disease and its main etiological agents. 61
32828066 2020
18
Intestinal anisakiasis with severe intestinal ischemia caused by extraluminal live larvae: a case report. 61
33001287 2020
19
Colonic anisakiasis, an infrequent case molecularly characterized by PCR-RFLP. 61
33069491 2020
20
A Case of Anaphylaxis with Mild Abdominal Pain Due to Gastroallergic Anisakiasis. 61
32289306 2020
21
Author Correction: Analysis of Ani s 7 and Ani s 1 allergens as biomarkers of sensitization and allergy severity in human anisakiasis. 61
33110175 2020
22
Endoscopic submucosal dissection of colonic anisakiasis. 61
32954766 2020
23
Case of gastric anisakiasis with no symptoms. 61
32983508 2020
24
Gastric Anisakiasis. 61
32430110 2020
25
Usefulness of Ultrasound in the Diagnosis of Intestinal Anisakiasis. 61
32154595 2020
26
Asymptomatic Colonic Anisakiasis: Is It So Rare? 61
33250702 2020
27
IgE-mediated gastroallergic anisakiasis with eosinophilic oesophagitis: a case report. 61
32970535 2020
28
Occurrence and molecular identification of Anisakis larval type 1 (Nematoda: Anisakidae) in marketed fish in Egypt. 61
32801505 2020
29
Asymptomatic Anisakiasis in a Patient With Crohn Disease. 61
32142008 2020
30
Effect of freezing on the metabolic status of L3 larvae of Anisakis simplex s. s. 61
32247867 2020
31
Advances in Omic Studies Drive Discoveries in the Biology of Anisakid Nematodes. 61
32679891 2020
32
Analysis of Ani s 7 and Ani s 1 allergens as biomarkers of sensitization and allergy severity in human anisakiasis. 61
32647149 2020
33
Asymptomatic Colonic Anisakiasis. 61
32646737 2020
34
Case of anisakiasis presenting as an Amyand hernia. 61
32641316 2020
35
Anisakis and Hysterothylacium species in Mediterranean and North-East Atlantic fishes commonly consumed in Spain: Epidemiological, molecular and morphometric discriminant analysis. 61
32361053 2020
36
Anisakis simplex products impair intestinal epithelial barrier function and occludin and zonula occludens-1 localisation in differentiated Caco-2 cells. 61
32628665 2020
37
Comparative Proteomics Analysis of Anisakis simplex s.s.-Evaluation of the Response of Invasive Larvae to Ivermectin. 61
32604878 2020
38
Mass Spectrometry Based-Proteomic Analysis of Anisakis spp.: A Preliminary Study towards a New Diagnostic Tool. 61
32599802 2020
39
Immunoreactive Proteins in the Esophageal Gland Cells of Anisakis Simplex Sensu Stricto Detected by MALDI-TOF/TOF Analysis. 61
32580523 2020
40
Esophageal anisakiasis observed using magnifying endoscopy with narrow-band imaging. 61
32590853 2020
41
First case of human anisakiasis in Poland. 61
32044432 2020
42
Posterior Mediastinitis Caused by Esophageal Anisakiasis. 61
32360812 2020
43
[Investigation on the risk of of Anisakis infection among high - risk populations along the coastal areas of Jiangsu Province]. 61
32468791 2020
44
Comparison of risk factors between human intestinal and gastric Anisakiasis. 61
31730806 2020
45
Comparative Transcriptomics Reveals Clues for Differences in Pathogenicity between Hysterothylacium aduncum, Anisakissimplex sensu stricto and Anisakis pegreffii. 61
32197414 2020
46
Recent increase of ulcerative lesions caused by Anisakis spp. in cetaceans from the north-east Atlantic. 61
32100663 2020
47
Inhibition of Acetylcholinesterase by Wood Creosote and Simple Phenolic Compounds. 61
33268651 2020
48
Anisakiasis in a Canadian patient with incarcerated epigastric hernia. 61
32140413 2020
49
Anisakis Sensitization in the Croatian fish processing workers: Behavioral instead of occupational risk factors? 61
31986138 2020
50
Anisakiasis: The Importance of Prevention and the Role of Diet Therapy in Allergic Patients. 61
32392567 2020

Variations for Anisakiasis

Expression for Anisakiasis

Search GEO for disease gene expression data for Anisakiasis.

Pathways for Anisakiasis

Pathways related to Anisakiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.74 TPM4 TPM2 MT-CO2
2 10.51 TPM4 TPM2

GO Terms for Anisakiasis

Cellular components related to Anisakiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle thin filament tropomyosin GO:0005862 8.62 TPM4 TPM2

Biological processes related to Anisakiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle filament sliding GO:0030049 8.62 TPM4 TPM2

Molecular functions related to Anisakiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.62 TPM4 TPM2

Sources for Anisakiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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