MCID: ANS002
MIFTS: 32

Aniseikonia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Aniseikonia

MalaCards integrated aliases for Aniseikonia:

Name: Aniseikonia 12 44 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0050304
MeSH 44 D000839

Summaries for Aniseikonia

Disease Ontology : 12 A refractive error that is characterized by the significant difference in perceived sizes of an object between the two eyes.

MalaCards based summary : Aniseikonia is related to amblyopia and cycloplegia. An important gene associated with Aniseikonia is FOXE3 (Forkhead Box E3), and among its related pathways/superpathways are Primary immunodeficiency and Cytokines and Inflammatory Response. The drugs Anesthetics and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include eye and retina, and related phenotype is vision/eye.

Wikipedia : 73 Aniseikonia is an ocular condition where there is a significant difference in the perceived size of... more...

Related Diseases for Aniseikonia

Diseases related to Aniseikonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 amblyopia 30.5 PITX3 PAX6 FOXE3
2 cycloplegia 30.3 IRX6 IRX3
3 cataract 29.4 PITX3 PAX6 OCRL MAF GALK1 FOXE3
4 anisometropia 10.7
5 strabismus 10.4
6 mechanical strabismus 10.4
7 retinal detachment 10.3
8 suppression amblyopia 10.3
9 refractive error 10.3
10 lateral displacement of eye 10.2 IRX6 IRX3
11 disuse amblyopia 10.2 PITX3 FOXE3
12 transient refractive change 10.2 IRX6 IRX3
13 anterior segment dysgenesis 2 10.2 PITX3 FOXE3
14 cataract-glaucoma 10.2 PITX3 OCRL
15 myopia 10.2
16 congenital aphakia 10.2 PAX6 FOXE3
17 macular retinal edema 10.1
18 macular holes 10.1
19 eye accommodation disease 10.1 IRX6 IRX3 FOXE3
20 sclerocornea 10.1 PAX6 FOXE3
21 hydrophthalmos 10.1 PAX6 OCRL
22 ablepharon-macrostomia syndrome 10.1 PAX6 OCRL
23 astigmatism 10.1
24 ayme-gripp syndrome 10.0 PITX3 MAF
25 axenfeld-rieger syndrome 10.0 PITX3 PAX6 FOXE3
26 axenfeld-rieger syndrome, type 1 10.0 PITX3 PAX6 FOXE3
27 anterior segment dysgenesis 1 10.0 PITX3 PAX6 FOXE3
28 iris disease 10.0 PITX3 PAX6 FOXE3
29 juvenile glaucoma 10.0 PITX3 PAX6 FOXE3
30 glaucoma 3, primary congenital, a 10.0 PAX6 OCRL FOXE3
31 senile cataract 10.0
32 farsightedness 10.0
33 spastic ataxia 8 10.0 PAX6 MAF
34 peters-plus syndrome 9.9 PITX3 PAX6 FOXE3
35 microphthalmia, syndromic 3 9.9 PAX6 FOXE3
36 early-onset non-syndromic cataract 9.9 PITX3 MAF FOXE3
37 pyomyositis 9.8 CSF3 CD4
38 splenic abscess 9.8 CSF3 CD4
39 anisocoria 9.8
40 exudative vitreoretinopathy 1 9.8
41 polykaryocytosis inducer 9.8
42 myasthenia gravis 9.8
43 retinitis pigmentosa 9.8
44 retinoschisis 1, x-linked, juvenile 9.8
45 macular degeneration, age-related, 1 9.8
46 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.8
47 ifap syndrome 2 9.8
48 neuroretinitis 9.8
49 retinal vein occlusion 9.8
50 central retinal vein occlusion 9.8

Graphical network of the top 20 diseases related to Aniseikonia:



Diseases related to Aniseikonia

Symptoms & Phenotypes for Aniseikonia

MGI Mouse Phenotypes related to Aniseikonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.17 GALK1 IRX3 IRX6 MAF OCRL PAX6

Drugs & Therapeutics for Aniseikonia

Drugs for Aniseikonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics
2 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Can we Measure Aniseikonia Tolerance in a Normal Population Unknown status NCT03832335
2 Aniseikonia in Epiretinal Membranes Unknown status NCT03661593
3 Change of Retinally-Induced Aniseikonia in Patients With Epiretinal Membrane After Vitrectomy Completed NCT01901406
4 Retinal Displacement After Pneumatic Retinopexy Versus Vitrectomy for the Management of Primary Retinal Detachment Recruiting NCT04089033
5 Correlation of Metamorphopsia and Aniseikonia to Retinal Shift Following Retinal Detachment Surgery Active, not recruiting NCT03187613

Search NIH Clinical Center for Aniseikonia

Cochrane evidence based reviews: aniseikonia

Genetic Tests for Aniseikonia

Anatomical Context for Aniseikonia

MalaCards organs/tissues related to Aniseikonia:

40
Eye, Retina

Publications for Aniseikonia

Articles related to Aniseikonia:

(show top 50) (show all 411)
# Title Authors PMID Year
1
Visual functions affecting stereopsis in patients with branch retinal vein occlusion. 61
33707764 2021
2
Meridional aniseikonia-causes, symptoms, and therapies. 61
33607272 2021
3
Incidence of Clinically Significant Aniseikonia Following Encircling Scleral Buckle Surgery: An Evaluation of Refractive and Axial Length Changes Requiring Intervention. 61
33546116 2021
4
Measuring aniseikonia tolerance range for stereoacuity - a tool for the refractive surgeon. 61
32558241 2021
5
Monocular and binocular visual parameters associated to vision-related quality of life in patients with epiretinal membrane: a prospective cohort. 61
33394162 2021
6
Capsular bag phimosis. 61
33319123 2020
7
Monocular and binocular end-points after epiretinal membrane surgery and their correlation to patient-reported outcomes. 61
32323909 2020
8
Comparison of blur and magnification effects on stereopsis: overall and meridional, monocularly- and binocularly-induced. 61
32776575 2020
9
Binocular Interference vs Diplopia in Patients With Epiretinal Membrane. 61
32910144 2020
10
Visual Acuity Inadequately Reflects Vision-Related Quality of Life in Patients After Macula-Off Retinal Detachment Surgery. 61
32805003 2020
11
Field-wide Quantification of Aniseikonia Using Dichoptic Localization. 61
32833405 2020
12
A comparative study of orthokeratology and low-dose atropine for the treatment of anisomyopia in children. 61
32843658 2020
13
The tolerance of anisometropia. 61
31773911 2020
14
CORRELATION BETWEEN MACULAR MICROSTRUCTURES AND ANISEIKONIA AFTER IDIOPATHIC EPIRETINAL MEMBRANE REMOVAL. 61
30932997 2020
15
Effects of simulated anisometropia and aniseikonia on stereopsis. 61
32128857 2020
16
Preoperative aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane. 61
32080768 2020
17
Changes in aniseikonia of an axial anisometrope at various stages of orthokeratology lens wear. 61
31732264 2020
18
Vision-related parameters that affect stereopsis in patients with macular hole. 61
32071368 2020
19
Anisometropic Amblyopia: Interocular Contrast and Viewing Luminance Effects on Aniseikonia. 61
32714637 2020
20
Comparative analysis of metamorphopsia and aniseikonia after vitrectomy for epiretinal membrane, macular hole, or rhegmatogenous retinal detachment. 61
32384099 2020
21
The relationship between clinical measures of aniseikonia and stereoacuity before and after LASIK. 61
31668775 2020
22
Evaluation of aniseikonia with an auto-stereoscopic smartphone. 61
31930043 2019
23
Aniseikonia and anisometropia: implications for suppression and amblyopia. 61
30791133 2019
24
Topical Review: Retinally Induced Aniseikonia. 61
31592961 2019
25
Changes in aniseikonia and influencing-factors following successful macula-off retinal detachment surgery. 61
31406166 2019
26
Dynamics of the accommodative response under artificially-induced aniseikonia. 61
31132345 2019
27
Prospective study of vitrectomy for epiretinal membranes in patients with good best-corrected visual acuity. 61
31412813 2019
28
Aniseikonia: A 21st Century Look. 61
31058577 2019
29
Binocular Visual Discomfort after First Eye Cataract Surgery: An Inattentive Burning Issue. 61
31086142 2019
30
New Onset vs Resolution of Central-Peripheral Rivalry-Type Diplopia in Patients Undergoing Epiretinal Membrane Peeling. 61
30543335 2019
31
Relationship between the morphology of the foveal avascular zone and the degree of aniseikonia before and after vitrectomy in patients with unilateral epiretinal membrane. 61
30637451 2019
32
New advances in amblyopia therapy II: refractive therapies. 61
29871968 2018
33
POSTOPERATIVE CHANGES AND PROGNOSTIC FACTORS OF VISUAL ACUITY, METAMORPHOPSIA, AND ANISEIKONIA AFTER VITRECTOMY FOR EPIRETINAL MEMBRANE. 61
28858064 2018
34
Comparison of visual acuity, metamorphopsia, and aniseikonia in patients with an idiopathic epiretinal membrane. 61
29623543 2018
35
Rapid neuroadaptation to surgically-induced aniseikonia in a 17-year-old patient with high preoperative anisometropia: A case report. 61
29577095 2018
36
Associations of aniseikonia with metamorphopsia and retinal displacements after epiretinal membrane surgery. 61
28937146 2018
37
Prevalence and Associations of Central-Peripheral Rivalry-Type Diplopia in Patients With Epiretinal Membrane. 61
29145554 2017
38
The correction of static and dynamic aniseikonia with spectacles and contact lenses. 61
28208213 2017
39
Aniseikonia in various retinal disorders. 61
28124146 2017
40
Evaluation of newly-developed aniseikonia testing method based on space eikonometry. 61
27553456 2017
41
Intraocular lens exchange for high myopia in pseudophakic children. 61
27419831 2016
42
Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole. 61
27406114 2016
43
[Electronic eikonometer: Measurement tests displayed on stereoscopic screen]. 61
27185662 2016
44
[Intraocular lens explantation and secondary implantation of a light-adjustable lens. Video article]. 61
27048549 2016
45
A Robust and Reliable Test to Measure Stereopsis in the Clinic. 61
26934135 2016
46
RESTORATION OF RETINALLY INDUCED ANISEIKONIA IN PATIENTS WITH EPIRETINAL MEMBRANE AFTER EARLY VITRECTOMY. 61
26352554 2016
47
Relationship Between Vertical and Horizontal Aniseikonia Scores and Vertical and Horizontal OCT Images in Idiopathic Epiretinal Membrane. 61
26451682 2015
48
Aniseikonia Tests: The Role of Viewing Mode, Response Bias, and Size-Color Illusions. 61
26101722 2015
49
Aniseikonia induced by cataract surgery and its effect on binocular vision. 61
25546829 2015
50
[Stereo Vision Deterioration by Artificially Induced Aniseikonia]. 61
26782920 2015

Variations for Aniseikonia

Expression for Aniseikonia

Search GEO for disease gene expression data for Aniseikonia.

Pathways for Aniseikonia

Pathways related to Aniseikonia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 LCK CD4
2 10.09 CSF3 CD4

GO Terms for Aniseikonia

Cellular components related to Aniseikonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin GO:0000785 9.1 PITX3 PAX6 MAF IRX6 IRX3 FOXE3

Biological processes related to Aniseikonia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.89 PITX3 PAX6 MAF IRX6 CSF3
2 regulation of transcription by RNA polymerase II GO:0006357 9.88 PITX3 PAX6 MAF IRX6 IRX3 FOXE3
3 regulation of transcription, DNA-templated GO:0006355 9.85 PITX3 PAX6 MAF IRX6 IRX3 FOXE3
4 T cell differentiation GO:0030217 9.51 LCK CD4
5 regulation of defense response to virus by virus GO:0050690 9.48 LCK CD4
6 negative regulation of neurogenesis GO:0050768 9.46 PITX3 PAX6
7 positive regulation of T cell activation GO:0050870 9.43 LCK CD4
8 lens fiber cell differentiation GO:0070306 9.32 PITX3 MAF
9 cornea development in camera-type eye GO:0061303 9.26 PAX6 FOXE3
10 lens development in camera-type eye GO:0002088 9.26 PITX3 PAX6 MAF FOXE3
11 iris morphogenesis GO:0061072 9.16 PAX6 FOXE3
12 cell development GO:0048468 8.92 MAF IRX6 IRX3 FOXE3

Molecular functions related to Aniseikonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific double-stranded DNA binding GO:1990837 9.56 PITX3 PAX6 MAF IRX3
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.46 PITX3 PAX6 MAF IRX6
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.43 PITX3 PAX6 MAF IRX6 IRX3 FOXE3
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.1 PITX3 PAX6 MAF IRX6 IRX3 FOXE3

Sources for Aniseikonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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