MCID: ANS018
MIFTS: 32

Anismus

Categories: Neuronal diseases

Aliases & Classifications for Anismus

MalaCards integrated aliases for Anismus:

Name: Anismus 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050839
UMLS 74 C0267601

Summaries for Anismus

Disease Ontology : 12 A focal dystonia that is characterized by the failure of the pelvic floor muscles to relax during defecation.

MalaCards based summary : Anismus is related to constipation and pelvic organ prolapse. An important gene associated with Anismus is PDPR (Pyruvate Dehydrogenase Phosphatase Regulatory Subunit). The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and skin, and related phenotype is digestive/alimentary.

Wikipedia : 77 Anismus is the failure of the normal relaxation of pelvic floor muscles during attempted defecation. It... more...

Related Diseases for Anismus

Diseases related to Anismus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 constipation 10.6
2 pelvic organ prolapse 10.4
3 intussusception 10.3 CAMP PDPR
4 myofascial pain syndrome 10.3 CAMP TAC1
5 vasomotor rhinitis 10.2 TAC1 VIP
6 cryptosporidiosis 10.1 TAC1 VIP
7 diffuse pulmonary fibrosis 10.1 TAC1 VIP
8 anal spasm 10.1 CAMP KANTR
9 space motion sickness 10.1 FUT2 VIP
10 fungal esophagitis 10.1 ATP12A ATP4A
11 diclofenac allergy 10.1 ATP12A ATP4A
12 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
13 neonatal candidiasis 10.1 ATP12A ATP4A
14 photoallergic dermatitis 10.1 ATP12A ATP4A
15 squamous papillomatosis 10.1 ATP12A ATP4A
16 toxic megacolon 10.1 ATP12A ATP4A
17 aspiration pneumonitis 10.1 ATP12A ATP4A
18 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
19 paraphimosis 10.1 CAMP KANTR
20 gastric antral vascular ectasia 10.1 ATP12A ATP4A
21 granulomatous gastritis 10.1 ATP12A ATP4A
22 oculomotor nerve paralysis 10.1 CAMP KANTR
23 esophageal candidiasis 10.1 ATP12A ATP4A
24 third cranial nerve disease 10.1 CAMP KANTR
25 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
26 acute laryngitis 10.1 ATP12A ATP4A
27 laryngitis 10.1 ATP12A ATP4A
28 duodenitis 10.1 ATP12A ATP4A
29 rumination disorder 10.1 ATP12A ATP4A
30 active peptic ulcer disease 10.1 ATP12A ATP4A
31 congenital disorder of deglycosylation 10.0 ATP12A ATP4A
32 bladder calculus 10.0 ATP12A ATP4A
33 ischemic neuropathy 10.0 ATP12A ATP4A
34 bile reflux 10.0 ATP12A ATP4A
35 capillary disease 10.0 ATP12A ATP4A
36 peptic esophagitis 10.0 ATP12A ATP4A
37 dyskinesia of esophagus 10.0 ATP12A ATP4A
38 hernia, hiatus 10.0 ATP12A ATP4A
39 postsurgical hypothyroidism 10.0 ATP12A ATP4A
40 lymphocytic colitis 10.0 ATP12A ATP4A
41 esophageal atresia/tracheoesophageal fistula 10.0 ATP12A ATP4A
42 clostridium difficile colitis 10.0 ATP12A ATP4A
43 diarrhea 1, secretory chloride, congenital 10.0 ATP12A ATP4A
44 esophagitis, eosinophilic, 1 10.0 ATP12A ATP4A
45 microscopic colitis 10.0 ATP12A ATP4A
46 chronic laryngitis 10.0 ATP12A ATP4A
47 eosinophilic gastritis 10.0 ATP12A ATP4A
48 esophagus adenocarcinoma 10.0 ATP12A ATP4A
49 adie pupil 10.0 KANTR VIP
50 polyposis, skin pigmentation, alopecia, and fingernail changes 10.0 ATP12A ATP4A

Graphical network of the top 20 diseases related to Anismus:



Diseases related to Anismus

Symptoms & Phenotypes for Anismus

MGI Mouse Phenotypes related to Anismus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 ATP12A ATP4A FUT2 OXT PITX1

Drugs & Therapeutics for Anismus

Drugs for Anismus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
3
Nitroglycerin Approved, Investigational Phase 2, Phase 3 55-63-0 4510
4
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
5 Botulinum Toxins Phase 2, Phase 3
6 Neurotransmitter Agents Phase 2, Phase 3
7 Botulinum Toxins, Type A Phase 2, Phase 3,Not Applicable
8 Neuromuscular Agents Phase 2, Phase 3
9 Acetylcholine Release Inhibitors Phase 2, Phase 3
10 abobotulinumtoxinA Phase 2, Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
12 Cholinergic Agents Phase 2, Phase 3
13 Central Nervous System Depressants Phase 2, Phase 3
14 Anesthetics Phase 2, Phase 3,Not Applicable
15 Analgesics Phase 2, Phase 3
16 Anesthetics, Local Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Antirheumatic Agents Phase 2, Phase 3
19 Sodium Channel Blockers Phase 2, Phase 3
20 Analgesics, Non-Narcotic Phase 2, Phase 3
21 Cyclooxygenase Inhibitors Phase 2, Phase 3
22 Ketorolac Tromethamine Phase 2, Phase 3
23 Anti-Inflammatory Agents Phase 2, Phase 3
24 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
25 Diuretics, Potassium Sparing Phase 2, Phase 3
26 Anti-Arrhythmia Agents Phase 2, Phase 3
27 Hemostatics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Ultrasound and EMG Guided Botox Injection for the Treatment of Non-Relaxing Puborectalis Syndrome Unknown status NCT01780636 Phase 2, Phase 3 botulinum toxin
3 Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy Completed NCT01279551 Phase 2, Phase 3 0.4% nitroglycerin ointment;lidocaine cloridrato 2.5% ointment
4 Rectal Sensory Training - A Study of Two Techniques Completed NCT00982839 Phase 2
5 Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients Completed NCT00735605 Not Applicable
6 Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry Completed NCT02633592 Not Applicable
7 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
8 Role of MRI Defecography in Diagnosis of Obstructed Defecation Syndrome Not yet recruiting NCT03841006
9 Mechano-physiological Approach to Anorectal Function Terminated NCT00219518

Search NIH Clinical Center for Anismus

Genetic Tests for Anismus

Anatomical Context for Anismus

MalaCards organs/tissues related to Anismus:

42
Testes, Colon, Skin

Publications for Anismus

Articles related to Anismus:

(show top 50) (show all 53)
# Title Authors Year
1
Internal Rectal Prolapse, Anismus, and Obstructed Defecation Reconsidered. ( 31094969 )
2019
2
Use of Biofeedback Combined With Diet for Treatment of Obstructed Defecation Associated With Paradoxical Puborectalis Contraction (Anismus): Predictive Factors and Short-term Outcome. ( 26734969 )
2016
3
Endoanal/endovaginal ultrasound-assisted bilateral partial myotomy of the puborectalis for anismus. ( 26783028 )
2016
4
Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review. ( 27602248 )
2016
5
Current Situation on the Diagnosis of Anismus-Discordances Between Imaging and a Physiologic Study. ( 27847784 )
2016
6
Anismus, Physiology, Radiology: Is It Time for Some Pragmatism? A Comparative Study of Radiological and Anorectal Physiology Findings in Patients With Anismus. ( 27847787 )
2016
7
Anismus as a cause of functional constipation--experience from Serbia. ( 26043583 )
2015
8
Semi-closed bilateral partial miotomy of the puborectalis for anismus: a pilot study: Partial miotomy of the puborectalis for anismus. ( 26255256 )
2015
9
Psycho-echo-biofeedback: a novel treatment for anismus--results of a prospective controlled study. ( 24858578 )
2014
10
Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training. ( 25253964 )
2014
11
Excellent response rate of anismus to botulinum toxin if rectal prolapse misdiagnosed as anismus ('pseudoanismus') is excluded. ( 21689279 )
2012
12
Comparative study between surgical and non-surgical treatment of anismus in patients with symptoms of obstructed defecation: a prospective randomized study. ( 20499203 )
2010
13
Is dynamic two-dimensional anal ultrasonography useful in the assessment of anismus? A comparison with manometry. ( 21225147 )
2010
14
Comparative study between biofeedback retraining and botulinum neurotoxin in the treatment of anismus patients. ( 18719924 )
2009
15
Comparative study between botulinum toxin injection and partial division of puborectalis for treating anismus. ( 19039596 )
2009
16
A novel two-dimensional dynamic anal ultrasonography technique to assess anismus comparing with three-dimensional echodefecography. ( 19681980 )
2009
17
A novel procedure to assess anismus using three-dimensional dynamic anal ultrasonography. ( 17223941 )
2007
18
Rectal cooling test in the differentiation between constipation due to rectal inertia and anismus. ( 17357865 )
2007
19
Dynamic MR assessment of the anorectal angle and puborectalis muscle in pediatric patients with anismus: technique and feasibility. ( 17410575 )
2007
20
Anismus: a marker of multi-site functional disorders? ( 15034727 )
2004
21
Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus). ( 15500515 )
2004
22
Does water-perfused catheter overdiagnose anismus compared to balloon probe? ( 12523590 )
2002
23
Outlet obstruction due to anismus and rectal hyposensation: effect of biofeedback training. ( 12780659 )
2002
24
Predictive value of impaired evacuation at proctography in diagnosing anismus. ( 11517060 )
2001
25
Botulinum toxin type-A in therapy of patients with anismus. ( 11742168 )
2001
26
An increased rectal maximum tolerable volume and long anal canal are associated with poor short-term response to biofeedback therapy for patients with anismus with decreased bowel frequency and normal colonic transit time. ( 11052518 )
2000
27
Fecal seepage in males with paradoxically high resting anal tone may be associated with anismus. ( 10378612 )
1999
28
Functional outlet obstruction: anismus, spastic pelvic floor syndrome, and dyscoordination of the voluntary sphincter muscles. Definition, diagnosis, and treatment from the neurologic point of view. ( 10423057 )
1999
29
Transanal repair of rectocele corrects obstructed defecation if it is not associated with anismus. ( 10613472 )
1999
30
Biofeedback for anismus: has placebo effect been overlooked? ( 23577711 )
1999
31
Proctographic diagnosis of anismus. ( 9715170 )
1998
32
Clinical significance of anismus in encopresis. ( 9794197 )
1998
33
Randomised controlled trial of biofeedback training in persistent encopresis with anismus. ( 9797593 )
1998
34
Obturator internus muscle autotransfer: a new concept for the treatment of anismus. Clinical experience. ( 9013105 )
1997
35
Anismus: fact or fiction? ( 9293931 )
1997
36
Paradoxical sphincter contraction is rarely indicative of anismus. ( 9301508 )
1997
37
Patterns of anismus and the relation to biofeedback therapy. ( 8674369 )
1996
38
Initial North American experience with botulinum toxin type A for treatment of anismus. ( 8831524 )
1996
39
Biofeedback for anismus in 15 sexually abused women. ( 8876277 )
1996
40
The impact of anismus on the clinical outcome of rectocele repair. ( 8951514 )
1996
41
Proctographic features of anismus. ( 7480738 )
1995
42
Anismus and biofeedback: who benefits? ( 7552638 )
1995
43
Anismus as a marker of sexual abuse. Consequences of abuse on anorectal motility. ( 7628260 )
1995
44
Anismus and biofeedback. ( 1346178 )
1992
45
Anismus: the cause of constipation? Results of investigation and treatment. ( 1462616 )
1992
46
Evidence from dynamic integrated proctography to redefine anismus. ( 1467908 )
1992
47
Biofeedback in anismus: the truth be known? ( 1642211 )
1992
48
Biofeedback defaecation training for anismus. ( 1770287 )
1991
49
Outlet obstruction constipation (anismus) managed by biofeedback. ( 1955173 )
1991
50
Anismus in patients with normal and slow transit constipation. ( 2070236 )
1991

Variations for Anismus

Expression for Anismus

Search GEO for disease gene expression data for Anismus.

Pathways for Anismus

GO Terms for Anismus

Biological processes related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.48 ATP12A ATP4A
2 regulation of sensory perception of pain GO:0051930 9.46 OXT VIP
3 ATP hydrolysis coupled proton transport GO:0015991 9.43 ATP12A ATP4A
4 cellular sodium ion homeostasis GO:0006883 9.4 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.37 ATP12A ATP4A
6 positive regulation of ossification GO:0045778 9.32 OXT TAC1
7 positive regulation of renal sodium excretion GO:0035815 9.26 OXT TAC1
8 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
9 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
10 positive regulation of penile erection GO:0060406 8.62 OXT VIP

Molecular functions related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 OXT VIP
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Anismus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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