MCID: ANS018
MIFTS: 29

Anismus

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Anismus

MalaCards integrated aliases for Anismus:

Name: Anismus 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050839
UMLS 70 C0267601

Summaries for Anismus

Disease Ontology : 12 A focal dystonia that is characterized by the failure of the pelvic floor muscles to relax during defecation.

MalaCards based summary : Anismus is related to constipation and pelvic organ prolapse. An important gene associated with Anismus is PDPR (Pyruvate Dehydrogenase Phosphatase Regulatory Subunit), and among its related pathways/superpathways are Uptake and actions of bacterial toxins and Miscellaneous digestion events. The drugs Ketorolac and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 73 Anismus is the failure of normal relaxation of pelvic floor muscles during attempted defecation. It can... more...

Related Diseases for Anismus

Graphical network of the top 20 diseases related to Anismus:



Diseases related to Anismus

Symptoms & Phenotypes for Anismus

MGI Mouse Phenotypes related to Anismus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 CLCN2 GUCY2C NPR3 PDPR SNAP25 TAC1
2 cardiovascular system MP:0005385 9.1 CLCN2 GUCY2C NPR3 SNAP25 TAC1 VIP

Drugs & Therapeutics for Anismus

Drugs for Anismus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
2
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
3
Nitroglycerin Approved, Investigational Phase 2, Phase 3 55-63-0 4510
4 Sodium Channel Blockers Phase 2, Phase 3
5 Anti-Arrhythmia Agents Phase 2, Phase 3
6 Anesthetics, Local Phase 2, Phase 3
7 Vasodilator Agents Phase 2, Phase 3
8 Diuretics, Potassium Sparing Phase 2, Phase 3
9 Anesthetics Phase 2, Phase 3
10 Ketorolac Tromethamine Phase 2, Phase 3
11 abobotulinumtoxinA
12 Botulinum Toxins, Type A
13 Hemostatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy Completed NCT01279551 Phase 2, Phase 3 0.4% nitroglycerin ointment;lidocaine cloridrato 2.5% ointment
2 Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry: a Randomized Comparison of Measurements in the Seated and Left Lateral Positions Completed NCT02633592
3 Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients With Symptoms of Obstructed Defecation Completed NCT00735605
4 Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus? Recruiting NCT04155307

Search NIH Clinical Center for Anismus

Genetic Tests for Anismus

Anatomical Context for Anismus

MalaCards organs/tissues related to Anismus:

40
Colon

Publications for Anismus

Articles related to Anismus:

(show top 50) (show all 184)
# Title Authors PMID Year
1
Partial Division of Puborectalis Muscle with Lateral Internal Sphincterotomy: A Novel Surgical Technique for Management of Anal Hypertonia-Associated Anismus. 61
33481084 2021
2
Obstructed defecation syndrome associated with paradoxical puborectalis contraction: osteopathic treatment versus anal biofeedback. Results of a pilot study. 61
33638728 2021
3
A prospective study of anal symptoms and continence among obese patients before and after bariatric surgery. 61
32889691 2020
4
Megabowel with anismus. 61
31784854 2020
5
Impact of TRREMS on symptoms of obstructed defecation due to rectocele: predictive factors and outcomes. 61
31828573 2020
6
A Randomized Controlled Trial on the Effects of Electromyographic Biofeedback on Quality of Life and Bowel Symptoms in Elderly Women With Dyssynergic Defecation. 61
31487902 2019
7
Internal Rectal Prolapse, Anismus, and Obstructed Defecation Reconsidered. 61
31094969 2019
8
[Manometric characteristics in children with chronic constipation and acquired anorectal pathology]. 61
31333230 2019
9
Does 4D transperineal ultrasound have additional value over 2D transperineal ultrasound for diagnosing posterior pelvic floor disorders in women with obstructed defecation syndrome? 61
29882224 2018
10
The clinical value of magnetic resonance defecography in males with obstructed defecation syndrome. 61
29512048 2018
11
Accuracy of Four Imaging Techniques for Diagnosis of Posterior Pelvic Floor Disorders. 61
29016504 2017
12
Pilot cohort study of endoscopic botulinum neurotoxin injection in Parkinson's disease. 61
28847681 2017
13
Efficacy of Biofeedback Therapy in the Treatment of Dyssynergic Defecation in Community-Dwelling Elderly Women. 61
28059942 2017
14
Magnetic resonance defecography versus videodefecography in the study of obstructed defecation syndrome: Is videodefecography still the test of choice after 50 years? 61
28755255 2017
15
The usefulness of MR defecography in the evaluation of pelvic floor dysfunction: our experience using 3T MRI. 61
28386692 2017
16
Dynamic translabial ultrasound versus echodefecography combined with the endovaginal approach to assess pelvic floor dysfunctions: How effective are these techniques? 61
28674949 2017
17
Dynamic MR defecography of the posterior compartment: Comparison with conventional X-ray defecography. 61
28089181 2017
18
Correlation Between Echodefecography and 3-Dimensional Vaginal Ultrasonography in the Detection of Perineal Descent in Women With Constipation Symptoms. 61
27824705 2016
19
Current Situation on the Diagnosis of Anismus-Discordances Between Imaging and a Physiologic Study. 61
27847784 2016
20
Anismus, Physiology, Radiology: Is It Time for Some Pragmatism? A Comparative Study of Radiological and Anorectal Physiology Findings in Patients With Anismus. 61
27847787 2016
21
Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review. 61
27602248 2016
22
The role of the defaecating pouchogram in the assessment of evacuation difficulty after restorative proctocolectomy and pouch-anal anastomosis. 61
27338231 2016
23
Endoanal/endovaginal ultrasound-assisted bilateral partial myotomy of the puborectalis for anismus. 61
26783028 2016
24
Use of Biofeedback Combined With Diet for Treatment of Obstructed Defecation Associated With Paradoxical Puborectalis Contraction (Anismus): Predictive Factors and Short-term Outcome. 61
26734969 2016
25
Advancing treatment options for chronic idiopathic constipation. 61
26630260 2016
26
Semi-closed bilateral partial miotomy of the puborectalis for anismus: a pilot study: Partial miotomy of the puborectalis for anismus. 61
26255256 2015
27
The role of tridimensional dynamic ultrasound for pelvic floor evaluation. 61
25659535 2015
28
Association of compartment defects in anorectal and pelvic floor dysfunction with female outlet obstruction constipation (OOC) by dynamic MR defecography. 61
25967716 2015
29
Management of obstructed defecation. 61
25632177 2015
30
Anismus as a cause of functional constipation--experience from Serbia. 61
26043583 2015
31
The effect of biofeedback therapy on dyssynergic constipation in patients with or without Irritable Bowel Syndrome. 61
25538778 2014
32
Psycho-echo-biofeedback: a novel treatment for anismus--results of a prospective controlled study. 61
24858578 2014
33
Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training. 61
25253964 2014
34
Laparoscopic ventral rectopexy is effective for solitary rectal ulcer syndrome when associated with rectal prolapse. 61
24678526 2014
35
Use of dynamic 3-dimensional transvaginal and transrectal ultrasonography to assess posterior pelvic floor dysfunction related to obstructed defecation. 61
24401886 2014
36
A rare condition of anorectal dysfunction in a patient with multiple sclerosis: Coexistence of faecal incontinence and mechanical constipation: Report of case. 61
25460483 2014
37
Dyssynergic defecation: a treatable cause of persistent symptoms when inflammatory bowel disease is in remission. 61
24026401 2013
38
Water-perfused manometry vs three-dimensional high-resolution manometry: a comparative study on a large patient population with anorectal disorders. 61
24034300 2013
39
Botulinum toxin for conditions of the female pelvis. 61
23344218 2013
40
[Imaging of pelvic organ prolapse]. 61
24260837 2013
41
Barium proctography vs magnetic resonance proctography for pelvic floor disorders: a comparative study. 61
22251617 2012
42
Ultrasound in the investigation of posterior compartment vaginal prolapse and obstructed defecation. 61
22045564 2012
43
Rectocele--does the size matter? 61
22307846 2012
44
A novel three-dimensional dynamic anorectal ultrasonography technique for the assessment of perineal descent, compared with defaecography. 61
21781232 2012
45
The influence of age on posterior pelvic floor dysfunction in women with obstructed defecation syndrome. 61
22527926 2012
46
[Analysis of experience in the use of dynamic pelvic magnetic resonance imaging in the assessment of obstructive defaecation syndrome]. 61
22486952 2012
47
Management of patients with rectocele, multiple pelvic floor dysfunctions and obstructed defecation syndrome. 61
22767001 2012
48
Excellent response rate of anismus to botulinum toxin if rectal prolapse misdiagnosed as anismus ('pseudoanismus') is excluded. 61
21689279 2012
49
Influence of age, mode of delivery and parity on the prevalence of posterior pelvic floor dysfunctions. 61
22147132 2011
50
Prospective multicenter trial comparing echodefecography with defecography in the assessment of anorectal dysfunction in patients with obstructed defecation. 61
21552052 2011

Variations for Anismus

Expression for Anismus

Search GEO for disease gene expression data for Anismus.

Pathways for Anismus

GO Terms for Anismus

Biological processes related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.32 TAC1 NPR3
2 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.26 VIP NPR3
3 negative regulation of smooth muscle cell proliferation GO:0048662 9.16 VIP NPR3
4 digestion GO:0007586 8.96 GUCY2C GUCA2A
5 associative learning GO:0008306 8.62 TAC1 SNAP25

Molecular functions related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone binding GO:0017046 8.96 NPR3 GUCY2C
2 natriuretic peptide receptor activity GO:0016941 8.62 NPR3 GUCY2C

Sources for Anismus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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