MCID: ANS018
MIFTS: 31

Anismus

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Anismus

MalaCards integrated aliases for Anismus:

Name: Anismus 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050839
UMLS 73 C0267601

Summaries for Anismus

MalaCards based summary : Anismus is related to myofascial pain syndrome and vasomotor rhinitis. An important gene associated with Anismus is PDPR (Pyruvate Dehydrogenase Phosphatase Regulatory Subunit). The drugs Acetylcholine and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include testes and colon, and related phenotype is digestive/alimentary.

Wikipedia : 76 Anismus (or dyssynergic defecation) refers to the failure of the normal relaxation of pelvic floor... more...

Related Diseases for Anismus

Diseases related to Anismus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 myofascial pain syndrome 10.6 CAMP TAC1
2 vasomotor rhinitis 10.5 TAC1 VIP
3 urticaria pigmentosa 10.5 TAC1 VIP
4 anal spasm 10.4 CAMP KANTR
5 paraphimosis 10.4 CAMP KANTR
6 cryptosporidiosis 10.4 TAC1 VIP
7 oculomotor nerve paralysis 10.4 CAMP KANTR
8 third cranial nerve disease 10.4 CAMP KANTR
9 diffuse pulmonary fibrosis 10.4 TAC1 VIP
10 fungal esophagitis 10.4 ATP12A ATP4A
11 bladder calculus 10.4 ATP12A ATP4A
12 gastrointestinal neuroendocrine benign tumor 10.4 ATP12A ATP4A
13 neonatal candidiasis 10.4 ATP12A ATP4A
14 photoallergic dermatitis 10.4 ATP12A ATP4A
15 squamous papillomatosis 10.4 ATP12A ATP4A
16 acute laryngitis 10.4 ATP12A ATP4A
17 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
18 gastric neuroendocrine neoplasm 10.3 ATP12A ATP4A
19 toxic megacolon 10.3 ATP12A ATP4A
20 aspiration pneumonitis 10.3 ATP12A ATP4A
21 postsurgical hypothyroidism 10.3 ATP12A ATP4A
22 gastric antral vascular ectasia 10.3 ATP12A ATP4A
23 rectal disease 10.3 KANTR PDPR
24 esophageal candidiasis 10.3 ATP12A ATP4A
25 duodenitis 10.3 ATP12A ATP4A
26 rumination disorder 10.3 ATP12A ATP4A
27 bile reflux 10.3 ATP12A ATP4A
28 granulomatous gastritis 10.3 ATP12A ATP4A
29 adie pupil 10.3 KANTR VIP
30 active peptic ulcer disease 10.3 ATP12A ATP4A
31 laryngeal disease 10.3 ATP12A ATP4A
32 ischemic neuropathy 10.3 ATP12A ATP4A
33 capillary disease 10.3 ATP12A ATP4A
34 peptic esophagitis 10.3 ATP12A ATP4A
35 duodenal disease 10.3 ATP12A ATP4A
36 glomangiosarcoma 10.3 KANTR TAC1
37 dyskinesia of esophagus 10.3 ATP12A ATP4A
38 hernia, hiatus 10.3 ATP12A ATP4A
39 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
40 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
41 laryngitis 10.3 ATP12A ATP4A
42 lymphocytic colitis 10.3 ATP12A ATP4A
43 anteroseptal myocardial infarction 10.3 FUT2 KANTR
44 clostridium difficile colitis 10.3 ATP12A ATP4A
45 lower urinary tract calculus 10.3 ATP12A ATP4A
46 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
47 chronic laryngitis 10.2 ATP12A ATP4A
48 eosinophilic gastritis 10.2 ATP12A ATP4A
49 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
50 cranio-facial dystonia 10.2 CAMP KANTR

Graphical network of the top 20 diseases related to Anismus:



Diseases related to Anismus

Symptoms & Phenotypes for Anismus

MGI Mouse Phenotypes related to Anismus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 ATP12A ATP4A FUT2 OXT PITX1

Drugs & Therapeutics for Anismus

Drugs for Anismus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2, Phase 3 51-84-3 187
2
Ketorolac Approved Phase 2, Phase 3 74103-06-3, 66635-83-4 3826
3
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
4
Nitroglycerin Approved, Investigational Phase 2, Phase 3 55-63-0 4510
5 abobotulinumtoxinA Phase 2, Phase 3,Not Applicable
6 Botulinum Toxins Phase 2, Phase 3
7 Botulinum Toxins, Type A Phase 2, Phase 3,Not Applicable
8 Cholinergic Agents Phase 2, Phase 3
9 Neuromuscular Agents Phase 2, Phase 3
10 Neurotransmitter Agents Phase 2, Phase 3
11 onabotulinumtoxinA Phase 2, Phase 3,Not Applicable
12 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
13 Analgesics Phase 2, Phase 3
14 Analgesics, Non-Narcotic Phase 2, Phase 3
15 Anesthetics Phase 2, Phase 3,Not Applicable
16 Anesthetics, Local Phase 2, Phase 3
17 Anti-Arrhythmia Agents Phase 2, Phase 3
18 Anti-Inflammatory Agents Phase 2, Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
20 Antirheumatic Agents Phase 2, Phase 3
21 Central Nervous System Depressants Phase 2, Phase 3
22 Cyclooxygenase Inhibitors Phase 2, Phase 3
23 Diuretics, Potassium Sparing Phase 2, Phase 3
24 Ketorolac Tromethamine Phase 2, Phase 3
25 Sodium Channel Blockers Phase 2, Phase 3
26 Vasodilator Agents Phase 2, Phase 3
27 Hemostatics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
2 Ultrasound and EMG Guided Botox Injection for the Treatment of Non-Relaxing Puborectalis Syndrome Unknown status NCT01780636 Phase 2, Phase 3 botulinum toxin
3 Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy Completed NCT01279551 Phase 2, Phase 3 0.4% nitroglycerin ointment;lidocaine cloridrato 2.5% ointment
4 Rectal Sensory Training - A Study of Two Techniques Completed NCT00982839 Phase 2
5 Comparative Study Between Surgical and Non Surgical Treatment of Anismus in Patients Completed NCT00735605 Not Applicable
6 Seated Evaluation of Anorectal funcTion by High Resolution Anorectal Manometry Completed NCT02633592 Not Applicable
7 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
8 Mechano-physiological Approach to Anorectal Function Terminated NCT00219518

Search NIH Clinical Center for Anismus

Genetic Tests for Anismus

Anatomical Context for Anismus

MalaCards organs/tissues related to Anismus:

41
Testes, Colon

Publications for Anismus

Articles related to Anismus:

(show all 27)
# Title Authors Year
1
Endoanal/endovaginal ultrasound-assisted bilateral partial myotomy of the puborectalis for anismus. ( 26783028 )
2016
2
Current Situation on the Diagnosis of Anismus-Discordances Between Imaging and a Physiologic Study. ( 27847784 )
2016
3
Use of Biofeedback Combined With Diet for Treatment of Obstructed Defecation Associated With Paradoxical Puborectalis Contraction (Anismus): Predictive Factors and Short-term Outcome. ( 26734969 )
2016
4
Anismus, Physiology, Radiology: Is It Time for Some Pragmatism? A Comparative Study of Radiological and Anorectal Physiology Findings in Patients With Anismus. ( 27847787 )
2016
5
Efficacy and safety of botulinum toxin in treatment of anismus: A systematic review. ( 27602248 )
2016
6
Semi-closed bilateral partial miotomy of the puborectalis for anismus: a pilot study : Partial miotomy of the puborectalis for anismus. ( 26255256 )
2015
7
Anismus as a cause of functional constipation--experience from Serbia. ( 26043583 )
2015
8
Botulinum toxin type-A injection to treat patients with intractable anismus unresponsive to simple biofeedback training. ( 25253964 )
2014
9
Psycho-echo-biofeedback: a novel treatment for anismus--results of a prospective controlled study. ( 24858578 )
2014
10
Excellent response rate of anismus to botulinum toxin if rectal prolapse misdiagnosed as anismus ('pseudoanismus') is excluded. ( 21689279 )
2012
11
Is dynamic two-dimensional anal ultrasonography useful in the assessment of anismus? A comparison with manometry. ( 21225147 )
2010
12
Comparative study between surgical and non-surgical treatment of anismus in patients with symptoms of obstructed defecation: a prospective randomized study. ( 20499203 )
2010
13
Comparative study between botulinum toxin injection and partial division of puborectalis for treating anismus. ( 19039596 )
2009
14
A novel two-dimensional dynamic anal ultrasonography technique to assess anismus comparing with three-dimensional echodefecography. ( 19681980 )
2009
15
Comparative study between biofeedback retraining and botulinum neurotoxin in the treatment of anismus patients. ( 18719924 )
2009
16
A novel procedure to assess anismus using three-dimensional dynamic anal ultrasonography. ( 17223941 )
2007
17
Dynamic MR assessment of the anorectal angle and puborectalis muscle in pediatric patients with anismus: technique and feasibility. ( 17410575 )
2007
18
Rectal cooling test in the differentiation between constipation due to rectal inertia and anismus. ( 17357865 )
2007
19
Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus). ( 15500515 )
2004
20
Anismus: a marker of multi-site functional disorders? ( 15034727 )
2004
21
Does water-perfused catheter overdiagnose anismus compared to balloon probe? ( 12523590 )
2002
22
Outlet obstruction due to anismus and rectal hyposensation: effect of biofeedback training. ( 12780659 )
2002
23
Predictive value of impaired evacuation at proctography in diagnosing anismus. ( 11517060 )
2001
24
Botulinum toxin type-A in therapy of patients with anismus. ( 11742168 )
2001
25
An increased rectal maximum tolerable volume and long anal canal are associated with poor short-term response to biofeedback therapy for patients with anismus with decreased bowel frequency and normal colonic transit time. ( 11052518 )
2000
26
Functional outlet obstruction: anismus, spastic pelvic floor syndrome, and dyscoordination of the voluntary sphincter muscles. Definition, diagnosis, and treatment from the neurologic point of view. ( 10423057 )
1999
27
Transanal repair of rectocele corrects obstructed defecation if it is not associated with anismus. ( 10613472 )
1999

Variations for Anismus

Expression for Anismus

Search GEO for disease gene expression data for Anismus.

Pathways for Anismus

GO Terms for Anismus

Biological processes related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import GO:0010107 9.43 ATP12A ATP4A
2 ATP hydrolysis coupled proton transport GO:0015991 9.4 ATP12A ATP4A
3 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
4 positive regulation of ossification GO:0045778 9.32 OXT TAC1
5 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
6 positive regulation of renal sodium excretion GO:0035815 9.16 OXT TAC1
7 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Anismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 OXT VIP
2 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Anismus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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