Aliases & Classifications for Anisocoria

MalaCards integrated aliases for Anisocoria:

Name: Anisocoria 56 29

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
anisocoria:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 56 106240
MedGen 41 C0003079

Summaries for Anisocoria

MalaCards based summary : Anisocoria is related to horner's syndrome and alacrima, achalasia, and mental retardation syndrome. An important gene associated with Anisocoria is GMPPA (GDP-Mannose Pyrophosphorylase A). The drugs Amiodarone and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are fatigue and anisocoria

Wikipedia : 74 Anisocoria is a condition characterized by an unequal size of the eyes' pupils. Affecting up to 20% of... more...

More information from OMIM: 106240

Related Diseases for Anisocoria

Diseases related to Anisocoria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 horner's syndrome 11.6
2 alacrima, achalasia, and mental retardation syndrome 11.3
3 horner syndrome, congenital 11.2
4 achalasia-addisonianism-alacrima syndrome 11.2
5 mental retardation, x-linked, syndromic 17 11.2
6 lethal congenital contracture syndrome 2 11.2
7 gmppa-cdg 11.2
8 ptosis 10.3
9 headache 10.3
10 ocular motor apraxia 10.2
11 adie pupil 10.1
12 migraine with or without aura 1 10.1
13 kearns-sayre syndrome 10.1
14 hemiplegia 10.1
15 anhidrosis 10.1
16 cluster headache 10.1
17 head injury 10.1
18 strabismus 10.1
19 intraocular pressure quantitative trait locus 10.1
20 joint laxity, short stature, and myopia 10.1
21 paraganglioma 10.1
22 alternating exotropia 10.1
23 exotropia 10.1
24 myopia 10.1
25 neuritis 10.1
26 mechanical strabismus 10.1
27 carotid artery dissection 10.1
28 exophthalmos 10.1
29 pure autonomic failure 10.1
30 alcohol dependence 9.9
31 multiple sclerosis 9.9
32 glaucoma, primary open angle 9.9
33 keratitis, hereditary 9.9
34 motion sickness 9.9
35 exfoliation syndrome 9.9
36 retinoblastoma 9.9
37 thrombocytopenic purpura, autoimmune 9.9
38 torticollis 9.9
39 lymphoma, hodgkin, classic 9.9
40 ataxia and polyneuropathy, adult-onset 9.9
41 yemenite deaf-blind hypopigmentation syndrome 9.9
42 anxiety 9.9
43 ewing sarcoma 9.9
44 aspergillosis 9.9
45 multinodular goiter 9.9
46 primary congenital glaucoma 9.9
47 lymphoma 9.9
48 thrombosis 9.9
49 cycloplegia 9.9
50 asymptomatic neurosyphilis 9.9

Graphical network of the top 20 diseases related to Anisocoria:



Diseases related to Anisocoria

Symptoms & Phenotypes for Anisocoria

Human phenotypes related to Anisocoria:

31
# Description HPO Frequency HPO Source Accession
1 fatigue 31 HP:0012378
2 anisocoria 31 HP:0009916

Symptoms via clinical synopsis from OMIM:

56
Eyes:
unequal pupil size
uniocular, fatigue-induced mydriasis

Neuro:
normal neurologic examination

Clinical features from OMIM:

106240

Drugs & Therapeutics for Anisocoria

Drugs for Anisocoria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amiodarone Approved, Investigational 1951-25-3 2157
2
Lidocaine Approved, Vet_approved 137-58-6 3676
3 Anesthetics, Local
4 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Single-Site Non-Interventional Study to Evaluate the Diagnostic Accuracy and Repeatability of Pupil Measurements Using a Prototype Binocular Optical Coherence Tomography System. Completed NCT03081468
2 Percutaneous Left Stellate Ganglion Block In Out-of-hospital Cardiac Arrest Due to Refractory VEntricular Arrhythmias Recruiting NCT04168970
3 Impact of Herniation on WFNS Grading and Outcome in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial Active, not recruiting NCT02304328

Search NIH Clinical Center for Anisocoria

Genetic Tests for Anisocoria

Genetic tests related to Anisocoria:

# Genetic test Affiliating Genes
1 Anisocoria 29

Anatomical Context for Anisocoria

MalaCards organs/tissues related to Anisocoria:

40
Eye, Brain, Testes, Pituitary, Liver, Lung, Spinal Cord

Publications for Anisocoria

Articles related to Anisocoria:

(show top 50) (show all 797)
# Title Authors PMID Year
1
Fatigue-induced familial anisocoria. 56 61
2330952 1990
2
Transient mydriasis in toxoplasmosis retinochoroiditis. 61
32346651 2020
3
Automated Pupillometry Using a Prototype Binocular Optical Coherence Tomography System. 61
32114180 2020
4
Severe intracranial hypotension after a middle fossa approach for spontaneous otogenic pneumocephalus. Case report. 61
32565372 2020
5
Allgrove Syndrome: A Report of New Pathological Variants in the AAAS Gene. 61
32073457 2020
6
Surgical Venous Drainage Disconnection from Cavernous Sinus Dural Arteriovenous Fistula and Ruptured Varix. 61
31954912 2020
7
Atypical Horner's syndrome: frequency, features and aetiology in a paediatric population. 61
32424330 2020
8
Transient anisocoria after a traumatic cervical spinal cord injury: A case report. 61
30124383 2020
9
A case of cognitive impairment finding solution after the onset of anisocoria. 61
32451961 2020
10
Anisocoria as initial manifestation of multiple sclerosis. Use of 3 tesla magnetic resonance imaging. 61
32147131 2020
11
Anisocoria assessment in subjects with dark irides - Custom-built infrared screening device vs. millimeter ruler. 61
32331923 2020
12
Isolated Internal Ophthalmoplegia Secondary to Herpes Zoster Ophthalmicus: A Rare Case Report. 61
32395161 2020
13
Corticotroph adenoma and pituitary fungal infection: a rare association. 61
32213650 2020
14
Decompressive craniectomy in pediatric non-traumatic intracranial hypertension: a single center experience. 61
32186205 2020
15
An anisocoria that does not look right. 61
32219504 2020
16
Salty, Sweet and Difficult to Treat: A Case of Profound Hypernatremia in the Setting of Hyperosmotic Hyperglycemic State. 61
32300498 2020
17
A Comparative Analysis Between Four-Quadrant Osteoplastic Decompressive Craniotomy versus Conventional Decompressive Craniectomy for Traumatic Brain Injury. 61
31821915 2020
18
External Validation and Modification of the EDEMA Score for Predicting Malignant Brain Edema After Acute Ischemic Stroke. 61
31549349 2020
19
Internal Carotid Artery Dissection Presenting as Partial Horner's Syndrome and Vertigo. 61
32060548 2020
20
Frey syndrome-like developmental dysautonomia in a child with PHACE syndrome. 61
32101632 2020
21
Horner Syndrome from a Pediatric Otolaryngology Perspective. 61
31561707 2020
22
Unusual Phenotype and Disease Trajectory in Kearns-Sayre Syndrome. 61
32181031 2020
23
Brainstem folding in an influenza child with Dandy-Walker variant. 61
32047789 2020
24
Ischaemic Oculomotor Nerve Palsy Isolated to the Levator: A Case Report. 61
32165898 2019
25
Postoperative Horner Syndrome After Lung Transplantation. 61
31851026 2019
26
Reversible anisocoria due to inadvertent ocular exposure to topical anticholinergic treatment for primary axillary hyperhidrosis. 61
31836120 2019
27
The Prevalence of Physiological Anisocoria and its Clinical Significance - A Neurosurgical Perspective. 61
31857545 2019
28
Anisocoria: Realities, Recognition, and Remedial Aspects. 61
31911751 2019
29
Monocular Vision Loss: A Rare Cause. 61
31763610 2019
30
Long-term Outcomes of Critically Ill Patients With Stroke Requiring Mechanical Ventilation. 61
31676523 2019
31
Intracranial invasive mycosis mimicking hepatic encephalopathy in a patient with cirrhosis. 61
31776153 2019
32
Can the Red Reflex Test Detect Unequal Refractive Error? 61
31378518 2019
33
The "Blown Pupil": Imminent Death or Harmless Contamination? 61
31633111 2019
34
Arteritic Orbital Ischemia Producing Afferent and Efferent Pupillary Defects. 61
31524841 2019
35
Likelihood of Diagnosing Neuroblastoma in Isolated Horner Syndrome. 61
30801444 2019
36
Ropivacaine/Fentanyl vs. Bupivacaine/Fentanyl for Pain Control in Children after Thoracic Surgery: A Randomized Study. 61
31103498 2019
37
Anisocoria and diagnostic applications of pilocarpine - An eye opener. 61
31128931 2019
38
Case 3: Anisocoria in a 5-year old Girl. 61
31263046 2019
39
An Elementary Cause of Anisocoria in Intensive Care Unit. 61
31406451 2019
40
Don't Miss This! Red Flags in the Pediatric Eye Exam: Pupils. 61
31329052 2019
41
Evaluation of Clinical Criteria for Performing Brain CT-Scan in Patients with Mild Traumatic Brain Injury; A New Diagnostic Probe. 61
31392227 2019
42
Neuro-Ophthalmic Symptoms of Primary Headache Disorders: Why the Patient With Headache May Present to Neuro-Ophthalmology. 61
31022065 2019
43
Pharmacologic anisocoria due to nebulized ipratropium bromide: A diagnostic challenge. 61
30948255 2019
44
[Unilateral mydriasis: a complication of spine surgery in prone position]. 61
30914141 2019
45
Atypical Manifestation of Direct Low-Flow Carotid-Cavernous Fistula: Case Report and Review of the Literature. 61
30818073 2019
46
A 30 s test for quantitative assessment of a relative afferent pupillary defect (RAPD): the infrared pupillary asymmetry (IPA). 61
30746557 2019
47
Feasibility and Variability of Automated Pupillometry Among Stroke Patients and Healthy Participants: Potential Implications for Clinical Practice. 61
30489422 2019
48
Gardening and dilated pupils: an interesting case of anisocoria from Brugmansia versicolor. 61
30975362 2019
49
Isolated Anisocoria as a Presenting Stroke Code Symptom is Unlikely to Result in Alteplase Administration. 61
30322757 2019
50
Anisocoria after Posterior Spine Surgery: A Rare but Disastrous Complication - A Case Report and Literature Review. 61
32405498 2019

Variations for Anisocoria

Expression for Anisocoria

Search GEO for disease gene expression data for Anisocoria.

Pathways for Anisocoria

GO Terms for Anisocoria

Sources for Anisocoria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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