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MCID: ANS004
MIFTS: 35

Anisometropia

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Anisometropia

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MalaCards integrated aliases for Anisometropia:

Name: Anisometropia 12 43 15 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
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External Ids:

Disease Ontology 12 DOID:12273
ICD9CM 34 367.31
MeSH 43 D015858
SNOMED-CT 67 3289004
ICD10 32 H52.31
UMLS 71 C0003081
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Summaries for Anisometropia

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MalaCards based summary : Anisometropia is related to aniseikonia and suppression amblyopia, and has symptoms including aniseikonia An important gene associated with Anisometropia is DSE (Dermatan Sulfate Epimerase), and among its related pathways/superpathways is TGF-beta signaling pathway (KEGG). The drugs Tropicamide and Atropine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and cortex.

Wikipedia : 74 Anisometropia is when two eyes have unequal refractive power. Generally a difference in power of two... more...

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Related Diseases for Anisometropia

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Diseases related to Anisometropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 aniseikonia 31.3 PLAAT3 DSE DPT
2 suppression amblyopia 30.9 TNFRSF10C PLAAT3 NBL1 DSE A1CF
3 accommodative esotropia 30.8 TRARG1 PLAAT3
4 strabismus 30.7 TNFRSF10C PLAAT3 DSE DPT CYLC1 CRYAA
5 esotropia 30.6 PLAAT3 DSE DPT CYLC1 CRYAA
6 monofixation syndrome 30.3 TNFRSF10C PLAAT3
7 ametropic amblyopia 30.3 NBL1 DSE CYLC1
8 exotropia 30.2 TNFRSF10C PLAAT3 DPT CYLC1 CRYAA
9 regular astigmatism 30.2 TRARG1 DPT CYLC1
10 irregular astigmatism 30.1 TRARG1 IFITM2 CYLC1
11 amblyopia 30.0 TNFRSF10C PLAAT3 IFITM2 GCNT2 DSE DPT
12 congenital ptosis 29.8 DPT CRYAA
13 degenerative myopia 29.6 NDUFAF7 DPT
14 astigmatism 29.3 TRARG1 NBL1 IFITM2 GREM2 GREM1 DSE
15 presbyopia 28.8 TRARG1 NBL1 IFITM2 GREM2 DPT CTSC
16 cycloplegia 28.4 SARS1 NBL1 IFITM2 GREM2 GREM1 DSE
17 refractive error 10.9
18 joint laxity, short stature, and myopia 10.9
19 myopia 10.9
20 mechanical strabismus 10.8
21 ocular dominance 10.5
22 monocular esotropia 10.5
23 farsightedness 10.5
24 cataract 10.5
25 alternating exotropia 10.4
26 immature cataract 10.3 CYLC1 CRYAA
27 accommodative spasm 10.3 IFITM2 CYLC1
28 lacrimal duct defect 10.3
29 retinal detachment 10.3
30 disuse amblyopia 10.3 PLAAT3 CRYAA
31 retinal lattice degeneration 10.3 DPT CYLC1
32 leukocoria 10.2 GCNT2 CRYAA
33 exudative vitreoretinopathy 1 10.2
34 intraocular pressure quantitative trait locus 10.2
35 microvascular complications of diabetes 5 10.2
36 ptosis 10.2
37 neurofibromatosis 10.2
38 vitreous detachment 10.2 DPT CYLC1
39 corneal ectasia 10.1 TRARG1 IFITM2 CYLC1
40 retinal perforation 10.1 IFITM2 CRYAA
41 migraine with or without aura 1 10.1
42 polykaryocytosis inducer 10.1
43 eye disease 10.1
44 glioma 10.1
45 glial tumor 10.1
46 cataract 44 10.0 GCNT2 CRYAA
47 anisocoria 10.0
48 optic nerve hypoplasia, bilateral 10.0
49 myasthenia gravis 10.0
50 ocular motor apraxia 10.0

Graphical network of the top 20 diseases related to Anisometropia:



Diseases related to Anisometropia
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Symptoms & Phenotypes for Anisometropia

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UMLS symptoms related to Anisometropia:


aniseikonia
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Drugs & Therapeutics for Anisometropia

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Drugs for Anisometropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tropicamide Approved, Investigational Phase 4 1508-75-4 5593
2
Atropine Approved, Vet_approved Phase 3 51-55-8, 5908-99-6 174174
3
Acetaminophen Approved Phase 3 103-90-2 1983
4
Codeine Approved, Illicit Phase 3 76-57-3 5284371
5
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
6 Mydriatics Phase 3
7 Respiratory System Agents Phase 3
8 Parasympatholytics Phase 3
9 Cholinergic Agents Phase 3
10 Anti-Asthmatic Agents Phase 3
11 Anti-Arrhythmia Agents Phase 3
12 Neurotransmitter Agents Phase 3
13 Muscarinic Antagonists Phase 3
14 Cholinergic Antagonists Phase 3
15 Bronchodilator Agents Phase 3
16 Anesthetics Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 Narcotics Phase 3
19 Antitussive Agents Phase 3
20 Analgesics Phase 3
21 Analgesics, Opioid Phase 3
22 Antipyretics Phase 3
23 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
24
Timolol Approved Phase 1 26839-75-8 5478 33624
25
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
26 Adrenergic beta-Antagonists Phase 1
27 Antihypertensive Agents Phase 1
28 Adrenergic Agents Phase 1
29 Pharmaceutical Solutions Phase 1
30 Adrenergic Antagonists Phase 1
31
Calcium carbonate Approved, Investigational 471-34-1

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Pilot Study of Prevention Myopia in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4 atropine;tropicamide
2 Ten-year Follow-up of Laser in Situ Keratomileusis in Patients 8 to 15 Years Old Completed NCT00800774 Phase 4
3 Anisometropia Amblyopia Improved by Perceptual Learning and Patching Completed NCT00498641 Phase 3
4 Amblyopia Treatment Study Completed NCT00001864 Phase 3 Atropine
5 A Randomized Study of Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain Completed NCT02625753 Phase 3 Codeine;paracetamol;placebo
6 Amblyopia Treatment Study: Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
7 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
8 Investigation of Visual Plasticity by a Direct Current Stimulation of Occipital Cortex in Adult Amblyopia Completed NCT00097162 Phase 1
9 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
10 Phase 1 Study of Topical Beta Blocker to Prevent the Proliferative Stage of Infantile Hemangioma Terminated NCT01434849 Phase 1 topical 0.5% Timolol maleate;Control (placebo) group
11 Ocular Response Analyzer Assessment of Intraocular Pressure and Corneal Biomechanical Properties in Myopic and Anisometropic Patients Under Atropine Treatment Unknown status NCT00658502
12 Prospective Evaluation of a Smartphone Application, GoCheckKidsâ„¢ as a Photo Screening Tool in a Pediatric Population Completed NCT03119675
13 Visual Performance of New Apodized Diffractive Multifocal IOL With Addition of Plus Three Completed NCT01027533
14 Performance of Two Photoscreeners With Enhanced Housing Completed NCT04068129
15 Wavefront Analysis and Contrast Sensitivity After Cataract Surgery With Akreos AO Intraocular Lens Implantation: Clinical Comparative Study Completed NCT00863759
16 Vision Screening of the Four Year Old Children for the Detection of Amblyopia in The Town of Zagreb Completed NCT01430247
17 Standard Amblyopia Therapy in Adult Amblyopes Completed NCT03341780
18 Evaluating the Ocular Function of Adults With Autism Spectrum Disorder: Interrelationship Between Blinking Reflex and Cornea Innervation. Recruiting NCT04010422
19 Luminopia One Amblyopia Vision Improvement Study Recruiting NCT03608150
20 Neurovascular Coupling in Subjects With Amblyopia Recruiting NCT01746693
21 A Randomised Clinical Trial Objectively Comparing the Effect of Patching Therapy With Video Gaming for Amblyopia Recruiting NCT03767985
22 Can we Measure Aniseikonia Tolerance in a Normal Population Recruiting NCT03832335
23 Photorefractive Keratectomy for Anisometropic and Isoametropic Amblyopia in Children Refractory to Conventional Treatment Active, not recruiting NCT03610997
24 Optimized Visual Recovery in Adult Human Amblyopia Through Binocular Deprivation Active, not recruiting NCT02685423
25 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836
26 Effect of 3D Movie Viewing on Stereopsis in Strabismus and / or Anisometropic Amblyops Not yet recruiting NCT04315649
27 Macular and Retinal Changes in Unilateral Amblyopia Using Optical Coherence Tomography Not yet recruiting NCT04092361
28 Patching Versus Dichoptic Stimulation Using Virtual Reality in Anisometropic Amblyopia Not yet recruiting NCT04302701
29 Amblyopia and Neurovascular Coupling in the Retina of Humans Withdrawn NCT00312390
30 Myopia Progression in Children Wearing Near Center and Distance Center Multifocals - a Randomized Controlled Clinical Trial Withdrawn NCT03519490

Search NIH Clinical Center for Anisometropia

Cochrane evidence based reviews: anisometropia

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Genetic Tests for Anisometropia

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Anatomical Context for Anisometropia

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MalaCards organs/tissues related to Anisometropia:

40
Eye, Testes, Cortex, Retina, Brain, Kidney, Endothelial
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Publications for Anisometropia

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Articles related to Anisometropia:

(show top 50) (show all 1570)
# Title Authors PMID Year
1
Consecutive strabismus after infantile nystagmus syndrome surgery and potential risk factors. 61
32307586 2020
2
Pattern of Axial Length Growth in Children Myopic Anisometropes with Orthokeratology Treatment. 61
31821058 2020
3
Clinical observations of the effect of orthokeratology in children with myopic anisometropia. 61
32173255 2020
4
Measuring aniseikonia tolerance range for stereoacuity - a tool for the refractive surgeon. 61
32558241 2020
5
The tolerance of anisometropia. 61
31773911 2020
6
Spectrum of Binocular Vision Anomalies in Keratoconus Subjects. 61
32511164 2020
7
Femtosecond Laser-Assisted LASIK in Children With Hyperopia and Anisometropic Amblyopia: 7 Years of Follow-up. 61
32521023 2020
8
Effects of simulated anisometropia and aniseikonia on stereopsis. 61
32128857 2020
9
Detection of Amblyogenic Refractive Error Using the Spot Vision Screener in Children. 61
32413003 2020
10
Diagnostic accuracy and agreement between visual acuity charts for detecting significant refractive errors in preschoolers. 61
31566805 2020
11
Prevalence and Associations of Myopic Anisometropia in Chinese Adults. 61
31211720 2020
12
Intense versus standard regimens of intermittent occlusion therapy for unilateral moderate amblyopia in children: study protocol for a randomized controlled trial. 61
32345348 2020
13
Morphological ciliary muscle changes associated with form deprivation-induced myopia. 61
32045599 2020
14
Influence of prenatal environment and birth parameters on amblyopia, strabismus, and anisometropia. 61
32151573 2020
15
Is the severity of refractive error dependent on the quantity and extent of retinal laser ablation for retinopathy of prematurity? 61
31554947 2020
16
Long-term refractive outcomes in children with early diagnosis of moderate to high hyperopia. 61
32316817 2020
17
Binocular discrepancy in lateral rectus muscle attachment in intermittent exotropia with eye dominance. 61
32314031 2020
18
Ciliary muscle morphology and accommodative lag in hyperopic anisometropic children. 61
31916057 2020
19
Evaluation of All Causes of Visual Function Loss in Children With Congenital Blepharoptosis. 61
32203593 2020
20
Refractive outcome of intravitreal bevacizumab injection in comparison to spontaneous regression of retinopathy of prematurity (ROP). 61
31790628 2020
21
Functional and Morphologic Findings at Four Years After Intravitreal Bevacizumab or Laser for Type 1 ROP. 61
32211908 2020
22
Characterization of Unique Lens Morphology in a Cohort of Children with Familial Exudative Vitreoretinopathy. 61
32141791 2020
23
Two Patterns of Interocular Delay Revealed by Spontaneous Motion-in-Depth Pulfrich Phenomenon in Amblyopes with Stereopsis. 61
32181800 2020
24
Effectiveness of the iPhone GoCheck Kids smartphone vision screener in detecting amblyopia risk factors. 61
31904429 2020
25
Refractive Errors and Amblyopia Among Children Screened by the UCLA Preschool Vision Program in Los Angeles County. 61
31647932 2020
26
Effects of orthokeratology lens on axial length elongation in unilateral myopia and bilateral myopia with anisometropia children. 61
31862203 2020
27
Orthokeratology lens for management of myopia in anisometropic children: A contralateral study. 61
30910277 2020
28
Changes in aniseikonia of an axial anisometrope at various stages of orthokeratology lens wear. 61
31732264 2020
29
Prevalence of Strabismus and Its Impact on Vision-Related Quality of Life: Results from the German Population-Based Gutenberg Health Study. 61
32312635 2020
30
The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia. 61
32351721 2020
31
Two-Year Outcomes of Infants with Stage 2 or Higher Retinopathy of Prematurity: Results from a Large Multicenter Registry. 61
31480086 2020
32
Amblyopia Risk Factors in Newborns With Congenital Nasolacrimal Duct Obstruction. 61
31972039 2020
33
The influence of orthokeratology compression factor on ocular higher-order aberrations. 61
31264269 2020
34
A Randomized Noninferiority Trial of Wearing Adjustable Glasses versus Standard and Ready-made Spectacles among Chinese Schoolchildren: Wearability and Evaluation of Adjustable Refraction III. 61
31543351 2020
35
Prevalence of Refractive Errors in Iranian University Students in Kazerun. 61
32510017 2020
36
Correction of presbyopia: old problems with old (and new) solutions. 61
31734940 2020
37
Noninvasive stiffness assessment of the human lens nucleus in patients with anisometropia using an ultrasound elastography system. 61
32309175 2020
38
The impact of vision screening in preschool children on visual function in the Swedish adult population. 61
31127702 2019
39
Evaluation of aniseikonia with an auto-stereoscopic smartphone. 61
31930043 2019
40
Aniseikonia and anisometropia: implications for suppression and amblyopia. 61
30791133 2019
41
Dome-shaped macula: a potential protective factor for visual acuity after cataract surgery in patients with high myopia. 61
30602448 2019
42
Distribution of Refractive Errors among Healthy Infants and Young Children between the Age of 6 to 36 Months in Kuala Lumpur, Malaysia-A Pilot Study. 61
31783494 2019
43
Secondary 12-Month Ocular Outcomes of a Phase 1 Dosing Study of Bevacizumab for Retinopathy of Prematurity. 61
31697304 2019
44
Can the Red Reflex Test Detect Unequal Refractive Error? 61
31378518 2019
45
Determinants of subjective patient-reported quality of vision after small-incision lenticule extraction. 61
31585852 2019
46
[Evaluation of Ophthalmic Follow-up Care of Former Pre-term and Full-term Infants Aged from 4 to 10 Years in Germany - Results of the Wiesbaden Prematurity Study (WPS)]. 61
29117610 2019
47
Intraocular Lens Implantation during Early Childhood: A Report by the American Academy of Ophthalmology. 61
31230794 2019
48
Smartphone photography for screening amblyogenic conditions in children. 61
31546480 2019
49
Differential Experience-Dependent Plasticity of Form and Motion Mechanisms in Anisometropic Amblyopia. 61
31574139 2019
50
The Role of Binocularity in Anisometropic Amblyopia. 61
31486743 2019
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Variations for Anisometropia

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Expression for Anisometropia

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Search GEO for disease gene expression data for Anisometropia.
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Pathways for Anisometropia

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Pathways related to Anisometropia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
TGF-beta signaling pathway (KEGG) 36
10.77 NBL1 GREM2 GREM1
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GO Terms for Anisometropia

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Biological processes related to Anisometropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.5 NBL1 GREM2 GREM1
2 negative regulation of BMP signaling pathway GO:0030514 9.33 NBL1 GREM2 GREM1
3 negative regulation of monocyte chemotaxis GO:0090027 9.26 NBL1 GREM1
4 determination of dorsal identity GO:0048263 9.13 NBL1 GREM2 GREM1
5 sequestering of BMP from receptor via BMP binding GO:0038098 8.8 NBL1 GREM2 GREM1

Molecular functions related to Anisometropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 morphogen activity GO:0016015 9.16 NBL1 GREM1
2 receptor ligand activity GO:0048018 9.13 NBL1 GREM2 GREM1
3 BMP binding GO:0036122 8.8 NBL1 GREM2 GREM1
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Sources for Anisometropia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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