THC2
MCID: ANK019
MIFTS: 19

Ankrd26-Related Thrombocytopenia (THC2)

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Ankrd26-Related Thrombocytopenia

MalaCards integrated aliases for Ankrd26-Related Thrombocytopenia:

Name: Ankrd26-Related Thrombocytopenia 24
Thrombocytopenia 2 24
Thc2 24

Characteristics:


GeneReviews:

24
Penetrance Penetrance for thrombocytopenia is complete in individuals with an ankrd26 pathogenic variant. the risk of transformation to a myeloid malignancy is variable [noris et al 2013].

Classifications:



Summaries for Ankrd26-Related Thrombocytopenia

MalaCards based summary: Ankrd26-Related Thrombocytopenia, also known as thrombocytopenia 2, is related to thrombocytopenia and blood platelet disease. An important gene associated with Ankrd26-Related Thrombocytopenia is ANKRD26 (Ankyrin Repeat Domain Containing 26). Affiliated tissues include myeloid, lung and prostate.

GeneReviews: NBK507664

Related Diseases for Ankrd26-Related Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Thrombocytopenia 7 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Ankrd26-Related Thrombocytopenia

Diseases related to Ankrd26-Related Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 30.4 MYH9 ANKRD26
2 blood platelet disease 29.1 MYH9 ANKRD26
3 thrombocytopenia 2 11.6
4 radioulnar synostosis with amegakaryocytic thrombocytopenia 2 11.4
5 leukemia, chronic myeloid 10.3
6 myelodysplastic syndrome 10.3
7 leukemia, acute myeloid 10.2
8 acute myeloid leukemia with recurrent genetic anomaly 10.2
9 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.1
10 myeloma, multiple 10.1
11 chronic myelomonocytic leukemia 10.1
12 hematologic cancer 10.1
13 myeloid leukemia 10.1
14 pdgfrb-associated chronic eosinophilic leukemia 10.1
15 gray platelet syndrome 9.9
16 myelofibrosis 9.9
17 thrombocytopenia 4 9.9
18 polyploidy 9.9
19 thrombocytopenia due to platelet alloimmunization 9.9
20 amyloidosis, hereditary, transthyretin-related 9.7
21 beta-thalassemia 9.7
22 thalassemia 9.7
23 polyneuropathy 9.7
24 purpura 9.7
25 amyloidosis 9.7
26 hereditary transthyretin amyloidosis 9.7
27 acquired thrombocytopenia 9.7 MYH9 ANKRD26
28 myh-9 related disease 9.7 MYH9 ANKRD26
29 amegakaryocytic thrombocytopenia, congenital 9.7 MYH9 ANKRD26
30 glanzmann thrombasthenia 1 9.6 MYH9 ANKRD26
31 bernard-soulier syndrome 9.6 MYH9 ANKRD26

Graphical network of the top 20 diseases related to Ankrd26-Related Thrombocytopenia:



Diseases related to Ankrd26-Related Thrombocytopenia

Symptoms & Phenotypes for Ankrd26-Related Thrombocytopenia

Drugs & Therapeutics for Ankrd26-Related Thrombocytopenia

Search Clinical Trials, NIH Clinical Center for Ankrd26-Related Thrombocytopenia

Genetic Tests for Ankrd26-Related Thrombocytopenia

Anatomical Context for Ankrd26-Related Thrombocytopenia

Organs/tissues related to Ankrd26-Related Thrombocytopenia:

MalaCards : Myeloid, Lung, Prostate, Breast, Spinal Cord, Bone Marrow, Liver

Publications for Ankrd26-Related Thrombocytopenia

Articles related to Ankrd26-Related Thrombocytopenia:

(show top 50) (show all 215)
# Title Authors PMID Year
1
Clinic, pathogenic mechanisms and drug testing of two inherited thrombocytopenias, ANKRD26-related Thrombocytopenia and MYH9-related diseases. 62 24
29545013 2018
2
5'UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia. 62 24
28100250 2017
3
Successful use of eltrombopag for surgical preparation in a patient with ANKRD26-related thrombocytopenia. 62 24
27276516 2016
4
Analyses of Genetic and Clinical Parameters for Screening Patients With Inherited Thrombocytopenia with Small or Normal-Sized Platelets. 62 24
26175287 2015
5
Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. 62 24
24430186 2014
6
ANKRD26-related thrombocytopenia and myeloid malignancies. 62 24
24030261 2013
7
Inherited thrombocytopenias frequently diagnosed in adults. 62 24
23510089 2013
8
Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families. 62 24
21467542 2011
9
Clinical spectrum and clonal evolution in germline syndromes with predisposition to myeloid neoplasms. 24
28485484 2018
10
Spectrum of 5'UTR mutations in ANKRD26 gene in patients with inherited thrombocytopenia: c.-140C>G mutation is more frequent than expected. 24
28277066 2017
11
A novel ANKRD26 gene variant causing inherited thrombocytopenia in a family of Finnish origin: Another brick in the wall? 24
28109976 2017
12
Timing, rates and spectra of human germline mutation. 24
26656846 2016
13
Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults. 24
26693794 2016
14
ASXL1 mutated chronic myelomonocytic leukemia in a patient with familial thrombocytopenia secondary to germline mutation in ANKRD26. 24
26001113 2015
15
A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies. 24
24628296 2014
16
Inherited predisposition to acute myeloid leukemia. 24
25311743 2014
17
A missense mutation in ANKRD26 segregates with thrombocytopenia. 24
23869080 2013
18
Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists. 24
23636669 2013
19
Diagnosis and management of inherited thrombocytopenias. 24
23397552 2013
20
Evolution and expression of chimeric POTE-actin genes in the human genome. 24
17101985 2006
21
Prevalence and natural history of variants in the ANKRD26 gene: a short review and update of reported cases. 62
35587581 2022
22
Overall survival and toxicity of Y90 radioembolization for hepatocellular carcinoma patients in Barcelona Clinic Liver Cancer stage C (BCLC-C). 62
36396989 2022
23
[email protected] [email protected]: unexpected formation of triangular thorium carbide cluster inside fullerenes. 62
36425487 2022
24
Safety and Survival Outcomes of Lutetium-177-Prostate-Specific Membrane Antigen Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer with prior Radium-223 treatment: The RALU Study. 62
36302656 2022
25
ANKRD26-Related Thrombocytopenia and Predisposition to Myeloid Neoplasms. 62
35751752 2022
26
Inotersen and severe thrombocytopenia: 2 case reports and review. 62
35343431 2022
27
Sequence Analysis and Functional Verification of the Effects of Three Key Structural Genes, PdTHC2'GT, PdCHS and PdCHI, on the Isosalipurposide Synthesis Pathway in Paeonia delavayi var. lutea. 62
35628506 2022
28
Potential biomarkers for inherited thrombocytopenia 2 identified by plasma proteomics. 62
34101524 2022
29
Risk factors associated with venous and arterial neonatal thrombosis in the intensive care unit: a multicentre case-control study. 62
35148820 2022
30
Blockade of alpha2-adrenergic receptors in the caudal raphe region enhances the renal sympathetic nerve activity response to acute intermittent hypercapnia in rats. 62
35043650 2022
31
Acquired Thrombotic Thrombocytopenic Purpura Following BNT162b2 mRNA Coronavirus Disease Vaccination in a Japanese Patient. 62
34803105 2022
32
PD-1 inhibitors plus lenvatinib versus PD-1 inhibitors plus regorafenib in patients with advanced hepatocellular carcinoma after failure of sorafenib. 62
36176403 2022
33
Cardiovascular, neurological, and pulmonary events following vaccination with the BNT162b2, ChAdOx1 nCoV-19, and Ad26.COV2.S vaccines: An analysis of European data. 62
34710832 2021
34
Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. 62
34581763 2021
35
Atypical manifestations of acute viral hepatitis A in children in Bangladesh: Are these really uncommon? 62
34783989 2021
36
Pretreatment serum uric acid level is not a surrogate marker for the outcome of favipiravir treatment in COVID-19 patients. 62
34392669 2021
37
Relation between mutations in the 5' UTR of ANKRD26 gene and inherited thrombocytopenia with predisposition to myeloid malignancies. An Egyptian study. 62
32659145 2021
38
Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine. 62
34330722 2021
39
Familial thrombocytopenia due to a complex structural variant resulting in a WAC-ANKRD26 fusion transcript. 62
33857290 2021
40
Severe Cystic Echinococcosis-Associated Immune Thrombocytopenic Purpura: A Case Report. 62
34007368 2021
41
Role of Thrombopoietin Receptor Agonists in Inherited Thrombocytopenia. 62
33919295 2021
42
Cisplatin/capecitabine with intensity-modulated radiation therapy in anal squamous cell carcinoma: a preliminary study. 62
33556252 2021
43
BCR-ABL+ Chronic Myeloid Leukemia Arising in a Family With Inherited ANKRD26-Related Thrombocytopenia. 62
34250402 2021
44
Efficacy and safety of diazoxide for treating hyperinsulinemic hypoglycemia: A systematic review and meta-analysis. 62
33571197 2021
45
Update on the Use of Intravenous Immunoglobulin in Pregnancy. 62
33386311 2021
46
Sub-Tenon Injection of Triamcinolone Acetonide for Choroidal Mass in Sarcoidosis: A Case Report. 62
33542662 2021
47
Oxford-AstraZeneca Coronavirus Disease-2019 Vaccine-Induced Immune Thrombocytopenia on Day Two. 62
34395000 2021
48
TTR gene silencing therapy in post liver transplant hereditary ATTR amyloidosis patients. 62
32578459 2020
49
Major Bleeding and Risk of Death after Percutaneous Native Kidney Biopsies: A French Nationwide Cohort Study. 62
33060158 2020
50
Radioprotective Activity of the Nitric Oxide Synthase Inhibitor T1023. Toxicological and Biochemical Properties, Cardiovascular and Radioprotective Effects. 62
34609510 2020

Variations for Ankrd26-Related Thrombocytopenia

Expression for Ankrd26-Related Thrombocytopenia

Search GEO for disease gene expression data for Ankrd26-Related Thrombocytopenia.

Pathways for Ankrd26-Related Thrombocytopenia

GO Terms for Ankrd26-Related Thrombocytopenia

Sources for Ankrd26-Related Thrombocytopenia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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