MCID: ANK008
MIFTS: 37

Ankyloglossia

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Ankyloglossia

MalaCards integrated aliases for Ankyloglossia:

Name: Ankyloglossia 57 12 55 15
'tongue-Tie' 57
Tongue-Tie 12
Tongue Tie 29

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
ankyloglossia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 106280
Disease Ontology 12 DOID:0060604
ICD10 33 Q38.1
MeSH 44 C562396
MedGen 42 C0152415
SNOMED-CT via HPO 69 263681008 67787004

Summaries for Ankyloglossia

Disease Ontology : 12 A tongue disease characterized by an unusually short, thick lingual frenulum, a membrane connecting the underside of the tongue to the floor of the mouth.

MalaCards based summary : Ankyloglossia, also known as 'tongue-tie', is related to cleft palate, isolated and cleft palate with or without ankyloglossia, x-linked. An important gene associated with Ankyloglossia is TBX22 (T-Box 22), and among its related pathways/superpathways is Pathways Affected in Adenoid Cystic Carcinoma. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and bone, and related phenotypes are ankyloglossia and craniofacial

Wikipedia : 76 Ankyloglossia, also known as tongue-tie, is a congenital oral anomaly that may decrease mobility of the... more...

Description from OMIM: 106280

Related Diseases for Ankyloglossia

Graphical network of the top 20 diseases related to Ankyloglossia:



Diseases related to Ankyloglossia

Symptoms & Phenotypes for Ankyloglossia

Symptoms via clinical synopsis from OMIM:

57
Mouth:
ankyloglossia


Clinical features from OMIM:

106280

Human phenotypes related to Ankyloglossia:

32
# Description HPO Frequency HPO Source Accession
1 ankyloglossia 32 HP:0010296

MGI Mouse Phenotypes related to Ankyloglossia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.35 FOXC2 HRAS IRF6 LGR5 TBX22
2 digestive/alimentary MP:0005381 9.02 FOXC2 HRAS IRF6 LGR5 TBX22

Drugs & Therapeutics for Ankyloglossia

Drugs for Ankyloglossia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
2 tannic acid Approved, Nutraceutical Phase 1, Phase 2
3 Anesthetics Phase 1, Phase 2,Not Applicable
4 Central Nervous System Depressants Phase 1, Phase 2,Not Applicable
5 Peripheral Nervous System Agents Phase 1, Phase 2,Not Applicable
6 Anesthetics, Local Phase 1, Phase 2,Not Applicable
7
Alfentanil Approved, Illicit Not Applicable 71195-58-9 51263
8
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
9
Rocuronium Approved Not Applicable 119302-91-9, 143558-00-3 441290
10
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
11
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
12 Hemostatics Not Applicable
13 Trichostatin A Not Applicable
14 Analgesics Not Applicable
15 Analgesics, Opioid Not Applicable
16 Anesthetics, General Not Applicable
17 Anesthetics, Intravenous Not Applicable
18 Hypnotics and Sedatives Not Applicable
19 Narcotics Not Applicable
20 Neuromuscular Agents Not Applicable
21 Neuromuscular Blocking Agents Not Applicable
22 Neuromuscular Nondepolarizing Agents Not Applicable
23 Anti-Arrhythmia Agents Not Applicable
24 Diuretics, Potassium Sparing Not Applicable
25 Sodium Channel Blockers Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn Terminated NCT01274247 Phase 1, Phase 2 Topical Benzocaine
2 Efficacy of Neonatal Release of Ankyloglossia Completed NCT00967915 Not Applicable
3 Breastfeeding Improvement Following Tongue-tie and Lip-tie Release Completed NCT02642133 Not Applicable
4 Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort Study Completed NCT02936518 Not Applicable
5 Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy Completed NCT01550354 Not Applicable administration of propofol;administration of alfentanil;administration of rocuronium
6 Prospective Evaluation of Lingual Frenotomy in Newborns With Simultaneous Lip Tie for the Relief of Breastfeeding Pain. Recruiting NCT02141243 Not Applicable

Search NIH Clinical Center for Ankyloglossia

Genetic Tests for Ankyloglossia

Genetic tests related to Ankyloglossia:

# Genetic test Affiliating Genes
1 Tongue Tie 29

Anatomical Context for Ankyloglossia

MalaCards organs/tissues related to Ankyloglossia:

41
Tongue, Testes, Bone

Publications for Ankyloglossia

Articles related to Ankyloglossia:

(show top 50) (show all 75)
# Title Authors Year
1
Ankyloglossia: Cohort and Results of Frenulotomies within Primary Health Setting. ( 29870096 )
2018
2
Quality, Readability, and Trends for Websites on Ankyloglossia. ( 29774762 )
2018
3
Is the Neonatal Tongue Screening Test a valid and reliable tool for detecting ankyloglossia in newborns? ( 29767443 )
2018
4
Ankyloglossia ( 29493920 )
2018
5
What does the world think of ankyloglossia? ( 29385272 )
2018
6
Defining Tip-Frenulum Length for Ankyloglossia and Its Impact on Breastfeeding: A Prospective Cohort Study. ( 29620937 )
2018
7
Familial autosomal dominant severe ankyloglossia with tooth abnormalities. ( 29704302 )
2018
8
The prevalence of ankyloglossia in 302 newborns with breastfeeding problems and sucking difficulties in Barcelona: a descriptive study. ( 29380619 )
2017
9
A novel finding of oligodontia and ankyloglossia in a 14-year-old with Floating-Harbor syndrome. ( 29210485 )
2017
10
Familial Ankyloglossia -A Rare Report of three Cases in a Family. ( 28384993 )
2017
11
Ankyloglossia in Infancy: An Indian Experience. ( 28285282 )
2017
12
Ankyloglossia as a risk factor for maxillary hypoplasia and soft palate elongation: A functional - morphological study. ( 28994495 )
2017
13
Ankyloglossia and Lingual Frenotomy: National Trends in Inpatient Diagnosis and Management in the United States, 1997-2012. ( 28168891 )
2017
14
ANKYLOGLOSSIA AND ITS INFLUENCE ON GROWTH AND DEVELOPMENT OF THE STOMATOGNATHIC SYSTEM. ( 28977337 )
2017
15
Toward a functional definition of ankyloglossia: validating current grading scales for lingual frenulum length and tongue mobility in 1052 subjects. ( 28097623 )
2017
16
Changes in the incidence and surgical treatment of ankyloglossia in Canada. ( 29479253 )
2017
17
Ease in Bag and Mask Ventilation: Is Ankyloglossia in a Child with Micrognathia a Blessing in Disguise? ( 28928596 )
2017
18
Breastfeeding Infants with Ankyloglossia: Insight into Mothers' Experiences. ( 28061033 )
2017
19
Ankyloglossia: Surgical management and functional rehabilitation of tongue. ( 29072224 )
2017
20
Effect of frenotomy on breastfeeding variables in infants with ankyloglossia (tongue-tie): a prospective before and after cohort study. ( 29132414 )
2017
21
Diagnosis and Treatment of Ankyloglossia in Newborns and Infants: A Review. ( 28715533 )
2017
22
Management of posterior ankyloglossia and upper lip ties in a tertiary otolaryngology outpatient clinic. ( 27497378 )
2016
23
To cut or not to cut? Approach to ankyloglossia. ( 26975914 )
2016
24
Office-based frenotomy for ankyloglossia and problematic breastfeeding. ( 27412212 )
2016
25
An Alternative Method to Treat Ankyloglossia. ( 27471811 )
2016
26
Temporal trends in ankyloglossia and frenotomy in British Columbia, Canada, 2004-2013: a population-based study. ( 27280112 )
2016
27
Management of Ankyloglossia and Breastfeeding Difficulties in the Newborn: Breastfeeding Sessions, Myofunctional Therapy, and Frenotomy. ( 27688921 )
2016
28
Should family physicians perform frenotomy for neonatal ankyloglossia? ( 26929731 )
2016
29
Multidisciplinary management of ankyloglossia in childhood. Treatment of 101 cases. A protocol. ( 26595832 )
2016
30
Newborn Infant With Epidermolysis Bullosa and Ankyloglossia. ( 26833212 )
2016
31
Evaluation of Hyoid Position in Children of 7-11 Years Old with Ankyloglossia in Lateral Cephalometic Radiographs. ( 28694853 )
2016
32
Ankyloglossia and the Breastfeeding Infant: Assessment and Intervention. ( 27003478 )
2016
33
Diagnosis and treatment of ankyloglossia: A narrative review and a report of three cases. ( 27222891 )
2016
34
Ankyloglossia superior syndrome: Case report and updated literature review. ( 27260569 )
2016
35
Labial ankyloglossia: A rare case report. ( 27994428 )
2016
36
Er, Cr:YSGG laser for the treatment of ankyloglossia. ( 26392733 )
2015
37
Ankyloglossia and breastfeeding. ( 26038641 )
2015
38
Breastfeeding difficulties and oral cavity anomalies: The influence of posterior ankyloglossia and upper-lip ties. ( 26255605 )
2015
39
Ankyloglossia with cleft lip: A rare case report. ( 26941523 )
2015
40
Treatment of ankyloglossia and breastfeeding outcomes: a systematic review. ( 25941303 )
2015
41
Is use of laser really essential for release of tongue-tie? ( 24785748 )
2014
42
Effectiveness of tongue-tie division for speech disorder in children. ( 25142274 )
2014
43
Tongue-tie and breastfeeding in newborns-mothers' perspective. ( 25290824 )
2014
44
X-linked CHARGE-like Abruzzo-Erickson syndrome and classic cleft palate with ankyloglossia result from TBX22 splicing mutations. ( 22784330 )
2013
45
Lingual leiomyomatous hamartoma with bifid tip and ankyloglossia in a patient without oral-facial-digital syndrome: a case report and literature review. ( 24040829 )
2013
46
Correspondence: Further studies on a kindred reported by Li 2009 as 'A new syndrome of ankyloglossia and ulnar ray defects in Newfoundland kindred'. From 'new syndrome' through EEC to ulnar mammary syndrome. ( 22391622 )
2012
47
Re: Andrade NN, Raikwar K. Congenital benign teratoma of the tongue with bifid tip, ankyloglossia and polydactyly: report of case. ( 22036031 )
2012
48
TBX22 and tongue-tie. ( 21905918 )
2012
49
Tongue-tie and breastfeeding: a review of the literature. ( 21608523 )
2011
50
Cleft lip with cleft palate, ankyloglossia, and hypodontia are associated with TBX22 mutations. ( 21248356 )
2011

Variations for Ankyloglossia

Expression for Ankyloglossia

Search GEO for disease gene expression data for Ankyloglossia.

Pathways for Ankyloglossia

Pathways related to Ankyloglossia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 HRAS SRCAP

GO Terms for Ankyloglossia

Sources for Ankyloglossia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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