MCID: ANK008
MIFTS: 39

Ankyloglossia

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Ankyloglossia

MalaCards integrated aliases for Ankyloglossia:

Name: Ankyloglossia 57 12 55 44 15
'tongue-Tie' 57
Tongue-Tie 12
Tongue Tie 29

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
ankyloglossia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 106280
Disease Ontology 12 DOID:0060604
ICD10 33 Q38.1
MedGen 42 C0152415
SNOMED-CT via HPO 69 263681008 67787004

Summaries for Ankyloglossia

Disease Ontology : 12 A tongue disease characterized by an unusually short, thick lingual frenulum, a membrane connecting the underside of the tongue to the floor of the mouth.

MalaCards based summary : Ankyloglossia, also known as 'tongue-tie', is related to cleft palate, isolated and cleft palate with or without ankyloglossia, x-linked. An important gene associated with Ankyloglossia is TBX22 (T-Box 22), and among its related pathways/superpathways is Pathways Affected in Adenoid Cystic Carcinoma. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include tongue, breast and bone, and related phenotypes are ankyloglossia and craniofacial

Wikipedia : 76 Ankyloglossia, also known as tongue-tie, is a congenital oral anomaly that may decrease mobility of the... more...

Description from OMIM: 106280

Related Diseases for Ankyloglossia

Graphical network of the top 20 diseases related to Ankyloglossia:



Diseases related to Ankyloglossia

Symptoms & Phenotypes for Ankyloglossia

Symptoms via clinical synopsis from OMIM:

57
Mouth:
ankyloglossia


Clinical features from OMIM:

106280

Human phenotypes related to Ankyloglossia:

32
# Description HPO Frequency HPO Source Accession
1 ankyloglossia 32 HP:0010296

MGI Mouse Phenotypes related to Ankyloglossia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 FOXC2 HRAS IRF6 LGR5 TBX22
2 digestive/alimentary MP:0005381 9.35 FOXC2 HRAS IRF6 LGR5 TBX22
3 respiratory system MP:0005388 8.92 FOXC2 HRAS LGR5 TBX22

Drugs & Therapeutics for Ankyloglossia

Drugs for Ankyloglossia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 1, Phase 2 94-09-7, 1994-09-7 2337
2 tannic acid Approved Phase 1, Phase 2
3 Central Nervous System Depressants Phase 1, Phase 2,Not Applicable
4 Peripheral Nervous System Agents Phase 1, Phase 2,Not Applicable
5 Anesthetics, Local Phase 1, Phase 2,Not Applicable
6 Anesthetics Phase 1, Phase 2,Not Applicable
7
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
8
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
9
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
10
Rocuronium Approved Not Applicable 119302-91-9, 143558-00-3 441290
11
Alfentanil Approved, Illicit Not Applicable 71195-58-9 51263
12 Anti-Arrhythmia Agents Not Applicable
13 Sodium Channel Blockers Not Applicable
14 Diuretics, Potassium Sparing Not Applicable
15 Hemostatics Not Applicable
16 Trichostatin A Not Applicable
17 Neuromuscular Agents Not Applicable
18 Neuromuscular Blocking Agents Not Applicable
19 Analgesics, Opioid Not Applicable
20 Analgesics Not Applicable
21 Narcotics Not Applicable
22 Neuromuscular Nondepolarizing Agents Not Applicable
23 Anesthetics, Intravenous Not Applicable
24 Anesthetics, General Not Applicable
25 Hypnotics and Sedatives Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn Terminated NCT01274247 Phase 1, Phase 2 Topical Benzocaine
2 Prospective Evaluation of Lingual Frenotomy in Newborns With Simultaneous Lip Tie for the Relief of Breastfeeding Pain. Unknown status NCT02141243 Not Applicable
3 Efficacy of Neonatal Release of Ankyloglossia Completed NCT00967915 Not Applicable
4 Breastfeeding Improvement Following Tongue-tie and Lip-tie Release Completed NCT02642133 Not Applicable
5 Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort Study Completed NCT02936518 Not Applicable
6 Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With Frenectomy Completed NCT01550354 Not Applicable administration of propofol;administration of alfentanil;administration of rocuronium
7 The Impact of Lingual Frenotomy on Bottle Feeding Mechanics Not yet recruiting NCT03793413 Not Applicable

Search NIH Clinical Center for Ankyloglossia

Cochrane evidence based reviews: ankyloglossia

Genetic Tests for Ankyloglossia

Genetic tests related to Ankyloglossia:

# Genetic test Affiliating Genes
1 Tongue Tie 29

Anatomical Context for Ankyloglossia

MalaCards organs/tissues related to Ankyloglossia:

41
Tongue, Breast, Bone, Testes, Colon

Publications for Ankyloglossia

Articles related to Ankyloglossia:

(show top 50) (show all 186)
# Title Authors Year
1
Ankyloglossia: Cohort and Results of Frenulotomies within Primary Health Setting. ( 29870096 )
2018
2
Quality, Readability, and Trends for Websites on Ankyloglossia. ( 29774762 )
2018
3
Is the Neonatal Tongue Screening Test a valid and reliable tool for detecting ankyloglossia in newborns? ( 29767443 )
2018
4
Ankyloglossia ( 29493920 )
2018
5
What does the world think of ankyloglossia? ( 29385272 )
2018
6
Defining Tip-Frenulum Length for Ankyloglossia and Its Impact on Breastfeeding: A Prospective Cohort Study. ( 29620937 )
2018
7
Familial autosomal dominant severe ankyloglossia with tooth abnormalities. ( 29704302 )
2018
8
Ankyloglossia as an oral functional problem and its surgical management. ( 30152627 )
2018
9
The prevalence of ankyloglossia in 302 newborns with breastfeeding problems and sucking difficulties in Barcelona: a descriptive study. ( 29380619 )
2017
10
A novel finding of oligodontia and ankyloglossia in a 14-year-old with Floating-Harbor syndrome. ( 29210485 )
2017
11
Familial Ankyloglossia -A Rare Report of three Cases in a Family. ( 28384993 )
2017
12
Ankyloglossia in Infancy: An Indian Experience. ( 28285282 )
2017
13
Ankyloglossia as a risk factor for maxillary hypoplasia and soft palate elongation: A functional - morphological study. ( 28994495 )
2017
14
Ankyloglossia and Lingual Frenotomy: National Trends in Inpatient Diagnosis and Management in the United States, 1997-2012. ( 28168891 )
2017
15
ANKYLOGLOSSIA AND ITS INFLUENCE ON GROWTH AND DEVELOPMENT OF THE STOMATOGNATHIC SYSTEM. ( 28977337 )
2017
16
Toward a functional definition of ankyloglossia: validating current grading scales for lingual frenulum length and tongue mobility in 1052 subjects. ( 28097623 )
2017
17
Changes in the incidence and surgical treatment of ankyloglossia in Canada. ( 29479253 )
2017
18
Ease in Bag and Mask Ventilation: Is Ankyloglossia in a Child with Micrognathia a Blessing in Disguise? ( 28928596 )
2017
19
Breastfeeding Infants with Ankyloglossia: Insight into Mothers' Experiences. ( 28061033 )
2017
20
Ankyloglossia: Surgical management and functional rehabilitation of tongue. ( 29072224 )
2017
21
Effect of frenotomy on breastfeeding variables in infants with ankyloglossia (tongue-tie): a prospective before and after cohort study. ( 29132414 )
2017
22
Diagnosis and Treatment of Ankyloglossia in Newborns and Infants: A Review. ( 28715533 )
2017
23
Management of posterior ankyloglossia and upper lip ties in a tertiary otolaryngology outpatient clinic. ( 27497378 )
2016
24
To cut or not to cut? Approach to ankyloglossia. ( 26975914 )
2016
25
Office-based frenotomy for ankyloglossia and problematic breastfeeding. ( 27412212 )
2016
26
An Alternative Method to Treat Ankyloglossia. ( 27471811 )
2016
27
Temporal trends in ankyloglossia and frenotomy in British Columbia, Canada, 2004-2013: a population-based study. ( 27280112 )
2016
28
Management of Ankyloglossia and Breastfeeding Difficulties in the Newborn: Breastfeeding Sessions, Myofunctional Therapy, and Frenotomy. ( 27688921 )
2016
29
Should family physicians perform frenotomy for neonatal ankyloglossia? ( 26929731 )
2016
30
Multidisciplinary management of ankyloglossia in childhood. Treatment of 101 cases. A protocol. ( 26595832 )
2016
31
Newborn Infant With Epidermolysis Bullosa and Ankyloglossia. ( 26833212 )
2016
32
Evaluation of Hyoid Position in Children of 7-11 Years Old with Ankyloglossia in Lateral Cephalometic Radiographs. ( 28694853 )
2016
33
Ankyloglossia and the Breastfeeding Infant: Assessment and Intervention. ( 27003478 )
2016
34
Diagnosis and treatment of ankyloglossia: A narrative review and a report of three cases. ( 27222891 )
2016
35
Ankyloglossia superior syndrome: Case report and updated literature review. ( 27260569 )
2016
36
Labial ankyloglossia: A rare case report. ( 27994428 )
2016
37
Er, Cr:YSGG laser for the treatment of ankyloglossia. ( 26392733 )
2015
38
Ankyloglossia and breastfeeding. ( 26038641 )
2015
39
Breastfeeding difficulties and oral cavity anomalies: The influence of posterior ankyloglossia and upper-lip ties. ( 26255605 )
2015
40
Ankyloglossia with cleft lip: A rare case report. ( 26941523 )
2015
41
Treatment of ankyloglossia and breastfeeding outcomes: a systematic review. ( 25941303 )
2015
42
Relationship between mandibular incisor irregularity and type of occlusion in ankyloglossia. ( 24914432 )
2015
43
Ankyloglossia (tongue-tie). ( 25659567 )
2015
44
Treatment of ankyloglossia for reasons other than breastfeeding: a systematic review. ( 25941312 )
2015
45
Is use of laser really essential for release of tongue-tie? ( 24785748 )
2014
46
Effectiveness of tongue-tie division for speech disorder in children. ( 25142274 )
2014
47
Tongue-tie and breastfeeding in newborns-mothers' perspective. ( 25290824 )
2014
48
Ankyloglossia and tongue mobility. ( 23860620 )
2014
49
Tissue-engineered oral mucosa for mucosal reconstruction in a pediatric patient with hemifacial microsomia and ankyloglossia. ( 23879858 )
2014
50
Letter to the editor regarding N. Sethi, et al., benefits of frenulotomy in infants with ankyloglossia, IJPO (2013), http://dx.doi.org/10.1016/j.ijporl.2013.02.005. ( 24393542 )
2014

Variations for Ankyloglossia

Expression for Ankyloglossia

Search GEO for disease gene expression data for Ankyloglossia.

Pathways for Ankyloglossia

Pathways related to Ankyloglossia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.44 HRAS SRCAP

GO Terms for Ankyloglossia

Sources for Ankyloglossia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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