MCID: ANK021
MIFTS: 23

Ankylosing Spondylitis 1

Categories: Bone diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Ankylosing Spondylitis 1

MalaCards integrated aliases for Ankylosing Spondylitis 1:

Name: Ankylosing Spondylitis 1 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080603

Summaries for Ankylosing Spondylitis 1

Disease Ontology : 12 A ankylosing spondylitis that has material basis in variation in the HLA-B27 allele on chromosome 6p21.3.

MalaCards based summary : Ankylosing Spondylitis 1 is related to ceftriaxone allergy and calciphylaxis. An important gene associated with Ankylosing Spondylitis 1 is ARHGAP26 (Rho GTPase Activating Protein 26). Affiliated tissues include bone, eye and lung, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Ankylosing Spondylitis 1

Diseases in the Juvenile Ankylosing Spondylitis family:

Ankylosing Spondylitis 1 Ankylosing Spondylitis 2
Ankylosing Spondylitis 3

Diseases related to Ankylosing Spondylitis 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
# Related Disease Score Top Affiliating Genes
1 ceftriaxone allergy 10.3 TNFRSF1B F3
2 calciphylaxis 10.3 FGF23 ALB
3 dental abscess 10.3 FGF23 CRP
4 anterior scleritis 10.2 TNFRSF1B CRP
5 scleritis 10.2 TNFRSF1B CRP
6 rheumatoid arthritis interstitial lung disease 10.2 TNFRSF1B CRP
7 orbital plasma cell granuloma 10.2 TNFRSF1B CRP
8 chronic orbital inflammation 10.2 TNFRSF1B CRP
9 optic papillitis 10.2 TNFRSF1B CRP
10 opportunistic bacterial infectious disease 10.2 TNFRSF1B CRP
11 nocardiosis 10.2 TNFRSF1B CRP
12 mononeuritis of upper limb and mononeuritis multiplex 10.2 TNFRSF1B CRP
13 mononeuritis multiplex 10.2 TNFRSF1B CRP
14 congenital intrinsic factor deficiency 10.2 F3 ALB
15 papillary adenofibroma 10.2 F3 F2
16 aortitis 10.2 TNFRSF1B CRP
17 neurosarcoidosis 10.2 TNFRSF1B CRP
18 femoral neuropathy 10.2 F3 F2
19 lateral sinus thrombosis 10.2 F3 F2
20 hypopyon 10.2 TNFRSF1B CRP
21 tenosynovitis 10.2 TNFRSF1B CRP
22 giant hemangioma 10.2 F3 F2
23 dic in newborn 10.2 F3 F2
24 pustulosis of palm and sole 10.2 TNFRSF1B CRP
25 chondromalacia 10.2 TNFRSF1B CRP
26 waterhouse-friderichsen syndrome 10.2 F3 F2
27 hemopneumothorax 10.2 F3 F2
28 scleral disease 10.2 TNFRSF1B CRP
29 non-a-e hepatitis 10.2 F2 ALB
30 antipyrine metabolism 10.2 F2 ALB
31 gastric hemangioma 10.2 F3 F2
32 qualitative platelet defect 10.2 F3 F2
33 hemopericardium 10.2 F3 F2
34 cerebral sinovenous thrombosis 10.2 F3 F2
35 good syndrome 10.2 TNFRSF1B CRP
36 prothrombin deficiency 10.2 F3 F2
37 chronic duodenal ileus 10.2 CRP ALB
38 bursitis 10.2 TNFRSF1B CRP
39 iritis 10.2 TNFRSF1B CRP
40 sagittal sinus thrombosis 10.2 F3 F2
41 iridocyclitis 10.2 TNFRSF1B CRP
42 cerebral falx meningioma 10.2 F3 F2
43 intracranial hypotension 10.2 F3 F2
44 orbital disease 10.2 TNFRSF1B CRP
45 tuberculous peritonitis 10.2 CRP ALB
46 peptic ulcer perforation 10.2 CRP ALB
47 splenic sequestration 10.2 F3 F2
48 disseminated chorioretinitis 10.2 TNFRSF1B GPT
49 acrodermatitis 10.1 TNFRSF1B ALB
50 meningovascular neurosyphilis 10.1 CRP ALB

Graphical network of the top 20 diseases related to Ankylosing Spondylitis 1:



Diseases related to Ankylosing Spondylitis 1

Symptoms & Phenotypes for Ankylosing Spondylitis 1

MGI Mouse Phenotypes related to Ankylosing Spondylitis 1:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 ABCG2 AIM2 ALB APCS CRP F2
2 immune system MP:0005387 9.28 ABCG2 AIM2 ALB APCS CRP F2

Drugs & Therapeutics for Ankylosing Spondylitis 1

Search Clinical Trials , NIH Clinical Center for Ankylosing Spondylitis 1

Genetic Tests for Ankylosing Spondylitis 1

Anatomical Context for Ankylosing Spondylitis 1

MalaCards organs/tissues related to Ankylosing Spondylitis 1:

40
Bone, Eye, Lung

Publications for Ankylosing Spondylitis 1

Articles related to Ankylosing Spondylitis 1:

(show all 25)
# Title Authors PMID Year
1
[Bone remodeling after total hip arthroplasty with anatomic medullary locking prosthesis and its long-term effectiveness]. 61
32538557 2020
2
A Challenging Case of Tumor-Induced Osteomalacia: Pathophysiological and Clinical Implications. 61
29736882 2018
3
Atlantoaxial Instability in a Patient with Neck Pain and Ankylosing Spondylitis. 61
29590445 2018
4
Profile of renal AA amyloidosis in older and younger individuals: a single-centre experience. 61
29775082 2018
5
Patients receiving chiropractic care in a neurorehabilitation hospital: a descriptive study. 61
29760552 2018
6
Epidemiology of rheumatic diseases in Mixtec and Chontal indigenous communities in Mexico: a cross-sectional community-based study. 61
26689797 2016
7
Chronic leg ulcers in adult patients with rheumatological diseases - a 7-year retrospective review. 61
23237056 2014
8
Safety and efficacy of golimumab in Chinese patients with active ankylosing spondylitis: 1-year results of a multicentre, randomized, double-blind, placebo-controlled phase III trial. 61
24729398 2014
9
The ClASsification for Psoriatic ARthritis (CASPAR) criteria--a retrospective feasibility, sensitivity, and specificity study. 61
22089469 2012
10
Clinical features and disease outcomes of undifferentiated arthritis in Thailand. 61
21816008 2011
11
Surgical correction of fixed kyphosis. 61
20411147 2007
12
Mycophenolate mofetil as an immunosuppressive agent in refractory inflammatory eye disease. 61
16808677 2006
13
Evaluation of spinal fusion using autologous anterior strut grafts and posterior instrumentation for thoracic/thoracolumbar kyphosis. 61
16025027 2005
14
Early results with the thrust plate prosthesis in young patients with osteoarthritis of the hip. 61
16152852 2005
15
Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study. 61
11212159 2001
16
[Aetiologic features of osteoporosis in male patients aged less than 50 years: study of 28 cases with a comparative series of 30 patients over the age of 50]. 61
9775196 1998
17
MICA allele typing of HLA-B27 positive Japanese patients with seronegative spondylarthropathies and healthy individuals: differential linkage disequilibrium with HLA-B27 subtypes. 61
9433871 1998
18
Clinical presentation and disease associations of gout: a hospital-based study of 100 patients in Singapore. 61
9588267 1998
19
[A comparative study of pulmonary elasticity and diffusion through the alveolocapillary membrane in major collagenoses with lung involvement]. 61
9289230 1997
20
Sex ratio in the spondyloarthropathies and its relationship to phenotypic expression, mode of inheritance and age at onset. 61
8308776 1993
21
Magnetic resonance imaging in patients with inflammatory arthritis of the knee. 61
2335054 1990
22
[Trans-synovial kinetics of tiaprofenic acid]. 61
3213265 1988
23
[Status of arthrosonography in rheumatologic diagnosis: examination technic, findings and their interpretation. I. The elbow joint]. 61
3518277 1986
24
Ultrastructure of synovial changes in rheumatoid disease and in seronegative inflammatory arthropathies. 61
6193628 1983
25
The therapeutic activity of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid monohydrate glucosamide in rheumatoid arthritis (double blind trial). 61
1098671 1975

Variations for Ankylosing Spondylitis 1

Expression for Ankylosing Spondylitis 1

Search GEO for disease gene expression data for Ankylosing Spondylitis 1.

Pathways for Ankylosing Spondylitis 1

GO Terms for Ankylosing Spondylitis 1

Cellular components related to Ankylosing Spondylitis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 TNFRSF1B FGF23 F3 F2 CRP APCS
2 blood microparticle GO:0072562 9.33 F2 APCS ALB
3 extracellular space GO:0005615 9.17 GPT FGF23 F3 F2 CRP APCS

Biological processes related to Ankylosing Spondylitis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 FGF23 F2 APCS ALB
2 negative regulation by host of viral process GO:0044793 8.96 CRP APCS
3 acute-phase response GO:0006953 8.8 F2 CRP APCS

Molecular functions related to Ankylosing Spondylitis 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 low-density lipoprotein particle binding GO:0030169 9.16 CRP APCS
2 virion binding GO:0046790 8.96 CRP APCS
3 complement component C1q binding GO:0001849 8.62 CRP APCS

Sources for Ankylosing Spondylitis 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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