MCID: ANK023
MIFTS: 22

Ankylosing Spondylitis 3

Categories: Bone diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Ankylosing Spondylitis 3

MalaCards integrated aliases for Ankylosing Spondylitis 3:

Name: Ankylosing Spondylitis 3 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080605

Summaries for Ankylosing Spondylitis 3

Disease Ontology : 12 A ankylosing spondylitis that has material basis in variation in the HLA-B allele on chromosome 2q36.1-q36.3.

MalaCards based summary : Ankylosing Spondylitis 3 is related to spondyloarthropathy 1 and esophageal atresia/tracheoesophageal fistula. An important gene associated with Ankylosing Spondylitis 3 is CHD7 (Chromodomain Helicase DNA Binding Protein 7), and among its related pathways/superpathways is Granzyme-A Pathway. Affiliated tissues include bone, and related phenotype is mortality/aging.

Related Diseases for Ankylosing Spondylitis 3

Diseases in the Juvenile Ankylosing Spondylitis family:

Ankylosing Spondylitis 1 Ankylosing Spondylitis 2
Ankylosing Spondylitis 3

Diseases related to Ankylosing Spondylitis 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 29.7 TNFRSF1B MRAP CRP
2 esophageal atresia/tracheoesophageal fistula 10.4 FANCB CHD7
3 trichorhinophalangeal syndrome, type iii 10.4 EXT1 CHD7
4 dysplasia epiphysealis hemimelica 10.4 EXT2 EXT1
5 hereditary multiple osteochondromas 10.4 EXT2 EXT1
6 osteochondroma 10.4 EXT2 EXT1
7 juxtacortical chondroma 10.4 EXT2 EXT1
8 olecranon bursitis 10.3 MRAP CRP
9 juvenile ankylosing spondylitis 10.3 TNFRSF1B MRAP
10 posterior scleritis 10.2 MRAP CRP
11 metachondromatosis 10.2 EXT2 EXT1
12 neuroretinitis 10.2 MRAP CRP
13 epididymo-orchitis 10.2 MRAP CRP
14 disseminated chorioretinitis 10.2 TNFRSF1B MRAP
15 chorioretinitis 10.2 TNFRSF1B MRAP
16 mesenteric lymphadenitis 10.2 MRAP CRP
17 balanitis 10.2 MRAP CRP
18 subdural empyema 10.2 RPL34 CRP
19 corneal dystrophy, band-shaped 10.2 TNFRSF1B MRAP
20 arachnoiditis 10.2 RPL34 CRP
21 toxocariasis 10.2 MRAP CRP
22 exostosis 10.2 MRAP EXT2 EXT1
23 sapho syndrome 10.1 TNFRSF1B MRAP
24 whipple disease 10.1 MRAP CRP
25 periostitis 10.1 MRAP CRP
26 immunodeficiency 43 10.1 FCGRT ALB
27 choroiditis 10.1 TNFRSF1B MRAP
28 epididymis disease 10.1 MRAP CRP
29 rheumatoid arthritis interstitial lung disease 10.1 TNFRSF1B CRP
30 multiple enchondromatosis, maffucci type 10.1 EXT2 EXT1
31 opportunistic bacterial infectious disease 10.1 TNFRSF1B CRP
32 nocardiosis 10.1 TNFRSF1B CRP
33 mononeuritis of upper limb and mononeuritis multiplex 10.0 TNFRSF1B CRP
34 urethritis 10.0 MRAP CRP
35 mononeuritis multiplex 10.0 TNFRSF1B CRP
36 neurosarcoidosis 10.0 TNFRSF1B CRP
37 discitis 10.0 RPL34 MRAP CRP
38 baastrup's syndrome 10.0 RPL34 MRAP CRP
39 chronic duodenal ileus 10.0 CRP ALB
40 cauda equina syndrome 10.0 RPL34 MRAP CRP
41 tuberculous peritonitis 10.0 CRP ALB
42 peptic ulcer perforation 10.0 CRP ALB
43 ascending cholangitis 10.0 CRP ALB
44 splenic abscess 10.0 CRP ALB
45 critical illness polyneuropathy 10.0 CRP ALB
46 meningovascular neurosyphilis 10.0 CRP ALB
47 acalculous cholecystitis 10.0 CRP ALB
48 good syndrome 10.0 TNFRSF1B CRP
49 gastrointestinal tuberculosis 10.0 CRP ALB
50 intestinal tuberculosis 10.0 CRP ALB

Graphical network of the top 20 diseases related to Ankylosing Spondylitis 3:



Diseases related to Ankylosing Spondylitis 3

Symptoms & Phenotypes for Ankylosing Spondylitis 3

MGI Mouse Phenotypes related to Ankylosing Spondylitis 3:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.36 ALB CHD7 COQ7 EXT1 EXT2 FCGRT

Drugs & Therapeutics for Ankylosing Spondylitis 3

Search Clinical Trials , NIH Clinical Center for Ankylosing Spondylitis 3

Genetic Tests for Ankylosing Spondylitis 3

Anatomical Context for Ankylosing Spondylitis 3

MalaCards organs/tissues related to Ankylosing Spondylitis 3:

40
Bone

Publications for Ankylosing Spondylitis 3

Articles related to Ankylosing Spondylitis 3:

(show all 15)
# Title Authors PMID Year
1
Secukinumab 150/300 mg Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis: 3-Year Results from the Phase 3 MEASURE 3 Study. 61
31957970 2020
2
Impact of baseline C-reactive protein levels on the response to secukinumab in ankylosing spondylitis: 3-year pooled data from two phase III studies. 61
30564451 2018
3
Long-term effects of interleukin-17A inhibition with secukinumab in active ankylosing spondylitis: 3-year efficacy and safety results from an extension of the Phase 3 MEASURE 1 trial. 61
28516874 2018
4
[Endoscopic sinus surgery for the treatment of invasive fungal sinusitis]. 61
29798357 2017
5
The Prevalence and Incidence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. 61
28453761 2017
6
Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice. 61
24351518 2015
7
[Coexisting rheumatoid arthritis and ankylosing spondylitis: 3 cases report]. 61
24535368 2014
8
Coexistence of ankylosing spondylitis and hereditary multiple exostoses:coincidence or association. 61
24693299 2014
9
Potential of (18)F-FDG-PET as a valuable adjunct to clinical and response assessment in rheumatoid arthritis and seronegative spondyloarthropathies. 61
23320137 2012
10
Evidence-based recommendations for the diagnosis of ankylosing spondylitis: results from the Australian 3E initiative in rheumatology. 61
18279132 2008
11
Etanercept 50 mg once weekly is as effective as 25 mg twice weekly in patients with ankylosing spondylitis. 61
16968715 2006
12
[The clinical causes of the thoracic ossification of ligamentum flavum]. 61
17217827 2006
13
[Hearing evaluation in patients with vertigo]. 61
16903346 2006
14
Etanercept: new indication. For ankylosing spondylitis: another option. 61
15981387 2005
15
Spinal stenosis due to posterior syndesmophytes in a patient with seronegative spondyloarthropathy. 61
7586986 1995

Variations for Ankylosing Spondylitis 3

Expression for Ankylosing Spondylitis 3

Search GEO for disease gene expression data for Ankylosing Spondylitis 3.

Pathways for Ankylosing Spondylitis 3

Pathways related to Ankylosing Spondylitis 3 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.83 PRF1 GZMA

GO Terms for Ankylosing Spondylitis 3

Biological processes related to Ankylosing Spondylitis 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 olfactory bulb development GO:0021772 9.32 EXT1 CHD7
2 cytolysis GO:0019835 9.26 PRF1 GZMA
3 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.16 EXT2 EXT1
4 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 8.96 EXT2 EXT1
5 cellular polysaccharide biosynthetic process GO:0033692 8.62 EXT2 EXT1

Molecular functions related to Ankylosing Spondylitis 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.16 EXT2 EXT1
2 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.96 EXT2 EXT1
3 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT2 EXT1

Sources for Ankylosing Spondylitis 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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