Aliases & Classifications for Ankylosis

MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 77 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD9CM 36 718.5 718.50
MeSH 45 D000844
SNOMED-CT 69 36504009
ICD10 34 M24.6
UMLS 74 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to auriculocondylar syndrome 1 and fibrodysplasia ossificans progressiva, and has symptoms including joint stiffness, arthralgia and metatarsalgia. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Celecoxib and Sulfasalazine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are Decreased IL-13 protein expression and cardiovascular system

Wikipedia : 77 Ankylosis is a stiffness of a joint due to abnormal adhesion and rigidity of the bones of the joint,... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 auriculocondylar syndrome 1 31.9 GNAI3 PLCB4
2 fibrodysplasia ossificans progressiva 31.8 ACVR1 BMP4 NOG
3 pfeiffer syndrome 31.7 BGLAP FGFR2 RUNX2 SP7
4 proximal symphalangism 31.3 BMP4 NOG
5 craniometaphyseal dysplasia, autosomal dominant 30.0 ACVR1 ANKH SP7
6 periodontitis 29.3 BGLAP RUNX2 TNFRSF11B
7 tooth agenesis 29.3 BMP2 BMP4 FGFR2
8 otosclerosis 29.2 BMP2 BMP4 NOG TNFRSF11B
9 osseous heteroplasia, progressive 28.5 ACVR1 BGLAP BMP2 BMP4 NOG RUNX2
10 osteoporosis 27.5 BGLAP BMP2 BMP4 IBSP RUNX2 SP7
11 tooth ankylosis 12.6
12 stapes ankylosis with broad thumbs and toes 12.6
13 temporomandibular ankylosis 12.5
14 permanent molars, secondary retention of 12.3
15 congenital temporomandibular joint ankylosis 12.2
16 glossopalatine ankylosis 12.2
17 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 12.1
18 glossopalatine ankylosis micrognathia ear anomalies 12.0
19 arthropathy 12.0
20 cardiocranial syndrome 11.7
21 spondyloarthropathy 1 11.4
22 piussan lenaerts mathieu syndrome 11.4
23 syngnathia 11.3
24 deafness, progressive, with stapes fixation 11.2
25 restrictive dermopathy, lethal 11.2
26 auriculocondylar syndrome 2 11.2
27 pseudoarthrogryposis 11.0
28 distal arthrogryposis 11.0
29 hypoglossia-hypodactylia 11.0
30 symphalangism, distal 11.0
31 symphalangism, proximal, 1a 11.0
32 auriculocondylar syndrome 3 11.0
33 multiple synostoses syndrome 11.0
34 charlie m syndrome 11.0
35 arthritis 10.6
36 spondylitis 10.5
37 rheumatoid arthritis 10.5
38 humeroradial synostosis 10.3 FGFR2 NOG
39 auriculo-condylar syndrome 10.2 GNAI3 PLCB4
40 osteoarthritis 10.2
41 root resorption 10.2
42 septic arthritis 10.2
43 noma 10.2
44 psoriatic arthritis 10.2
45 spondyloarthropathy 10.2
46 bone fracture 10.2 BGLAP BMP2
47 hyperostosis 10.1
48 sleep apnea 10.1
49 synostosis 10.1
50 osteochondroma 10.1

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


joint stiffness, arthralgia, metatarsalgia, joint symptom

GenomeRNAi Phenotypes related to Ankylosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-13 protein expression GR00219-A 8.62 ACVR1 FGFR2

MGI Mouse Phenotypes related to Ankylosis:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3
2 cellular MP:0005384 10.18 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
3 growth/size/body region MP:0005378 10.18 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
4 craniofacial MP:0005382 10.16 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
5 homeostasis/metabolism MP:0005376 10.06 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3
6 digestive/alimentary MP:0005381 10.04 ACVR1 BMP2 BMP4 FGFR2 IBSP NOG
7 hematopoietic system MP:0005397 10.03 ANKH BMP2 BMP4 FGFR2 GNAI3 IBSP
8 limbs/digits/tail MP:0005371 10.02 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
9 hearing/vestibular/ear MP:0005377 10 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
10 immune system MP:0005387 9.97 ACVR1 ANKH BMP2 FGFR2 GNAI3 IBSP
11 mortality/aging MP:0010768 9.96 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
12 muscle MP:0005369 9.7 ACVR1 ANKH BMP4 FGFR2 NOG PLCB4
13 respiratory system MP:0005388 9.43 ANKH BMP4 FGFR2 NOG RUNX2 SP7
14 skeleton MP:0005390 9.4 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 149)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
2
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5359476 5353980
3
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
4
Adalimumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 331731-18-1 16219006
5
Pamidronate Approved Phase 4 40391-99-9 4674
6
Infliximab Approved Phase 4,Phase 3,Phase 1,Not Applicable 170277-31-3
7
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
8
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 143 6006
9
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
11
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3 2921-57-5
12
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
13
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3 302-25-0
14
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
15
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
16
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
17
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
18
Acetaminophen Approved Phase 4 103-90-2 1983
19
Aceclofenac Approved, Investigational Phase 4 89796-99-6
20
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
21
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
22
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
23
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
24
Hydroxychloroquine Approved Phase 4 118-42-3 3652
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
26
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3 2920-86-7
27
Loxoprofen Investigational Phase 4 80382-23-6, 68767-14-6 3965
28 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
29 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
30 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
31 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Not Applicable
33 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Not Applicable
34 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
37 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
40 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Natriuretic Peptide, Brain Phase 4
42 Natriuretic Agents Phase 4
43 Folate Phase 4,Phase 3,Phase 2
44 Vitamin B9 Phase 4,Phase 3,Phase 2
45 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
46 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
47 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
48 Vitamin B Complex Phase 4,Phase 3,Phase 2
49 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
50 Antineoplastic Agents, Immunological Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 375)
# Name Status NCT ID Phase Drugs
1 Gait Analysis of Ankle Arthroplasty and Arthrodesis Unknown status NCT00921076 Phase 4
2 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
3 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Unknown status NCT02634541 Phase 4 Adalimumab
4 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
5 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
6 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
7 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
8 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib
9 A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis Completed NCT01162421 Phase 4 Methotrexate
10 Prevention of Heterotopic Ossification With Arcoxia After Total Hip Replacement Completed NCT01022190 Phase 4 Etoricoxib (Arcoxia)
11 Efficacy and Safety of Etanercept in Active RA Despite Methotrexate Therapy in Japan Completed NCT00688103 Phase 4 ETN Alone;ETN+MTX
12 A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies. Completed NCT00462345 Phase 4 rituximab;Methotrexate;Corticosteroid or NSAID
13 CAMEO: Canadian Methotrexate and Etanercept Outcome Study Completed NCT00654368 Phase 4 Methotrexate
14 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
15 A Pilot Study of the Feasibility of Discontinuation of Adalimumab in Stable Rheumatoid Arthritis Patients in Clinical Remission Completed NCT00808509 Phase 4 methotrexate
16 Treat-to-Target Strategy With Etanercept for Ankylosing Spondylitis Completed NCT03880968 Phase 4 tapering or discontinuation of etanercept
17 Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis Completed NCT03800797 Phase 4 Loxoprofen sodium hydrogel patch;Loxoprofen sodium tablet
18 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
19 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
20 Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis Completed NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
21 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
22 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
23 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
24 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
25 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
26 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
27 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
28 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
29 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
30 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
31 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
32 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
33 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
34 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
35 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
36 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
37 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
38 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
39 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
40 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
41 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
42 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
43 A Multicenter,Double-Blind and Randomized Controlled Trial of Fengshigutong Capsule in the Treatment of Ankylosing Spondylitis Recruiting NCT03932006 Phase 4 Fengshigutong Capsule plus Imrecoxib;Fengshigutong Capsule;Imrecoxib
44 A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis Recruiting NCT03733925 Phase 4 Golimumab
45 Treat-to-target With Secukinumab in Axial Spondyloarthritis Recruiting NCT03639740 Phase 4 Secukinumab 150 milligram [Cosentyx]
46 Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis Recruiting NCT03473665 Phase 4 Indomethacin;Diclofenac;Meloxicam;Celecoxib
47 Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS Recruiting NCT03411798 Phase 4 Yisaipu®
48 Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis Recruiting NCT03350815 Phase 4 150 mg open-label secukinumab;150 mg double-blinded secukinumab;300 mg double-blinded secukinumab
49 Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients Recruiting NCT02492217 Phase 4 Adalimumab
50 A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab (AIN457) to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis Active, not recruiting NCT02763046 Phase 4 AIN457/Secukinumab Placebo; Biological: AIN457/Secukinumab

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

42
Bone, Testes, Brain, Heart, Endothelial, T Cells, Skin

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 1232)
# Title Authors Year
1
Novel manifestation of Aicardi-Goutières syndrome: Temporomandibular joint ankylosis. ( 30690315 )
2019
2
Examination of OPG, RANK, RANKL and HIF1A polymorphisms in temporomandibular joint ankylosis patients. ( 30795980 )
2019
3
Anaesthetic management of bilateral temporomandibular joint ankylosis with cervical spine fusion for total alloplastic joint replacement in a patient with ankylosing spondylitis. ( 30814756 )
2019
4
Induced ankylosis of primary canines for absolute anchorage in the treatment of a patient with Class III malocclusion and cleft soft palate. ( 30826043 )
2019
5
Removal of the articular fibrous layers with discectomy leads to temporomandibular joint ankylosis. ( 30879912 )
2019
6
The role of lateral pterygoid muscle in the traumatic temporomandibular joint ankylosis: A gene chip based analysis. ( 30942403 )
2019
7
Temporomandibular Joint Ankylosis Release: 17 Years of Experience with 521 Joints. ( 30996537 )
2019
8
Evaluation of Total Alloplastic Temporomandibular Joint Replacement in TMJ Ankylosis. ( 30996554 )
2019
9
Outcomes of surgical management of TMJ ankylosis: A systematic review and meta-analysis. ( 31027859 )
2019
10
Gap arthroplasty with active mouth opening exercises using an interocclusal splint in temporomandibular joint ankylosis patients. ( 31058106 )
2019
11
C2 Vertebral Corpectomy for Kyphosis Malunion of Remote Dens Fracture with Atlantoaxial Ankylosis and Myelopathy: A Case Report at 15 Years of Follow-Up. ( 31107681 )
2019
12
Quality of life assessment in temporomandibular joint ankylosis patients after interpositional arthroplasty: a prospective study. ( 31109747 )
2019
13
Condyle-preserved arthroplasty versus costochondral grafting in paediatric temporomandibular joint ankylosis: a retrospective investigation. ( 30145062 )
2019
14
Simultaneous arthroplasty and distraction osteogenesis for the treatment of ankylosis of the temporomandibular joint and secondary mandibular deformities in children. ( 30600109 )
2019
15
Ultrasonic versus conventional gap arthroplasty for the release of ankylosis of temporomandibular joint: a prospective cohort study. ( 30674962 )
2019
16
Does Surgical Release of TMJ Bony Ankylosis Increase the Risk of Trigeminocardiac Reflex? A Retrospective Cohort Study. ( 30712536 )
2019
17
Treatment of Atypical Bifid Mandibular Condyle Associated with Ankylosis of the Temporomandibular Joint. ( 30733884 )
2019
18
Bilateral Spontaneous Bony Ankylosis of the Elbow Following Burn: A Case Report and Review of the Literature. ( 30740374 )
2018
19
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2018
20
Monitoring of incremental changes in maximum interincisal opening after gap arthroplasty omits the risk of Re-ankylosis. ( 29037918 )
2018
21
The First Record of Incidences of Ankylosis in Seven Triplefin Fishes (Pisces: Tripterygiidae) from New Zealand. ( 29059718 )
2018
22
Orthognathic treatment of facial asymmetry due to temporomandibular joint ankylosis. ( 29076326 )
2018
23
Grafts of autogenous coronoid process to reconstruct the mandibular condyle in children with unilateral ankylosis of the temporomandibular joint: long-term effects on mandibular growth. ( 29254874 )
2018
24
Interpositional Arthroplasty by Temporalis Fascia Flap and Galea Aponeurotica Combined With Distraction Osteogenesis: a Modified Method in Treatment of Adult Patients With Temporomandibular Joint Ankylosis and Mandibular Dysplasia. ( 29303852 )
2018
25
Cricoarytenoid Joint Ankylosis: Classification and Transoral Laser Microsurgical Treatment. ( 29306525 )
2018
26
Augmentation surgery on the cartilaginous portion of the vocal fold in a patient with cricoarytenoid joint ankylosis. ( 29307442 )
2018
27
Use of Kerrison Rongeur for safe and effective removal of bone in temporomandibular joint ankylosis. ( 29340886 )
2018
28
A Bone Conduction Implantable Device as a Functional Treatment Option in Unilateral Microtia with Bilateral Stapes Ankylosis: A Report of Two Cases. ( 29358571 )
2018
29
Management of Temporomandibular Joint Ankylosis With Dentofacial Deformities in Children. ( 29381640 )
2018
30
Double non-contiguous fractures in a patient with spondylo-epiphyseal dysplasia with spinal ankylosis treated with open and percutaneous spinal fixation technique: a case report. ( 29415765 )
2018
31
Evaluation of Hemoglobin Concentration and Hematocrit Values in Temporomandibular Joint Ankylosis Patients in Comparison to Nonankylosed Patients. ( 29422472 )
2018
32
Coexistence of Ankylosing Spondylitis and Myotonic Dystrophy: Camptocormia or Thoracic Ankylosis. ( 29465620 )
2018
33
Surgical treatment of hip ankylosis due to heterotopic ossification secondary to spinal cord injury. ( 29477350 )
2018
34
Temporomandibular Joint Ankylosis: Algorithm of Treatment. ( 29509170 )
2018
35
Protocol for Single-Stage Bilateral Temporomandibular Joint Replacement Using Intraoperative Navigation in Patients With Ankylosis. ( 29530748 )
2018
36
Traumatic Bony Ankylosis of Temporomandibular Joint as a Complication After Reduction Malarplasty. ( 29554062 )
2018
37
Retrograde intubation in a dog with severe temporomandibular joint ankylosis: case report. ( 29587754 )
2018
38
Temporomandibular Joint Ankylosis: "A Pediatric Difficult Airway Management". ( 29628599 )
2018
39
The sequential treatment of temporomandibular joint ankylosis with secondary deformities by distraction osteogenesis and arthroplasty or TMJ reconstruction. ( 29706239 )
2018
40
Delayed tooth reimplantation with 4-year follow-up: the management of ankylosis during facial growth. ( 29714701 )
2018
41
Endoscopically Assisted Transoral Gap Arthroplasty of the Temporomandibular Joint Ankylosis in a Pediatric Patient. ( 29742569 )
2018
42
Extra-Articular Ankylosis of the Coronoid Process With the Zygomatic Bone: A Rare Case Treated With an Alternative Approach. ( 29742575 )
2018
43
Concomitant Temporomandibular Joint Ankylosis and Maxillomandibular Fusion in a Child with Klippel- Feil Syndrome: A Case Report. ( 29763351 )
2018
44
Bilateral total mandibular reconstruction with patient specific implants for temporomandibular joint ankylosis. ( 29777779 )
2018
45
Temporomandibular Joint Ankylosis After Ramus Construction With Free Fibula Flaps in Children With Hemifacial Microsomia. ( 29852140 )
2018
46
Change in the posterior airway after mandibular distraction osteogenesis in patients with ankylosis of the temporomandibular joint: a retrospective study. ( 29887252 )
2018
47
Preserving the Fibrous Layer of the Mandibular Condyle Reduces the Risk of Ankylosis in a Sheep Model of Intracapsular Condylar Fracture. ( 29908889 )
2018
48
Zygomatico-coronoid Ankylosis as Sequel of Inadequate Treatment. ( 29963447 )
2018
49
Autogenous Dermis-fat Graft in Temporomandibular Joint Ankylosis Surgery. ( 29963448 )
2018
50
Clinical experience in managing temporomandibular joint ankylosis: five-year appraisal in a Nigerian subpopulation. ( 29963492 )
2018

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
2
Show member pathways
13.15 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
3
Show member pathways
12.8 BMP2 BMP4 FGFR2 GNAI3 PLCB4
4 12.6 BMP2 BMP4 FGFR2 GNAI3 PLCB4
5 11.89 BMP4 FGFR2 TNFRSF11B
6 11.87 ACVR1 BMP4 FGFR2
7 11.65 BGLAP GNAI3 PLCB4 RUNX2
8
Show member pathways
11.54 ACVR1 BMP2 BMP4 FGFR2 GNAI3 NOG
9
Show member pathways
11.53 BMP2 NOG RUNX2
10 11.53 ACVR1 BMP2 BMP4 NOG
11 11.4 BMP4 NOG RUNX2
12 11.28 BGLAP FGFR2 RUNX2
13 11.23 BGLAP RUNX2 TNFRSF11B
14 11.19 BGLAP IBSP RUNX2
15 11.03 GNAI3 PLCB4
16 10.97 BMP2 BMP4
17 10.91 BMP2 BMP4
18 10.85 BGLAP IBSP PLCB4 RUNX2
19 10.48 BGLAP IBSP TNFRSF11B

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 BGLAP BMP2 BMP4 FGFR2 IBSP NOG

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.94 ACVR1 BMP2 FGFR2 NOG
2 cartilage development GO:0051216 9.86 BMP2 BMP4 NOG
3 cell fate commitment GO:0045165 9.84 BMP2 BMP4 FGFR2
4 positive regulation of epithelial cell proliferation GO:0050679 9.83 BMP4 FGFR2 NOG
5 odontogenesis of dentin-containing tooth GO:0042475 9.83 BMP2 BMP4 RUNX2
6 ossification GO:0001503 9.83 BGLAP BMP2 BMP4 RUNX2
7 bone development GO:0060348 9.82 BGLAP BMP4 FGFR2
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 ACVR1 BMP2 BMP4
9 positive regulation of osteoblast differentiation GO:0045669 9.8 ACVR1 BMP2 BMP4 RUNX2
10 ureteric bud development GO:0001657 9.79 BMP4 FGFR2 NOG
11 chondrocyte differentiation GO:0002062 9.78 BMP2 BMP4 RUNX2
12 cellular response to growth factor stimulus GO:0071363 9.78 BGLAP BMP2 BMP4 IBSP
13 epithelial to mesenchymal transition GO:0001837 9.77 BMP2 FGFR2 NOG
14 embryonic cranial skeleton morphogenesis GO:0048701 9.77 BMP4 FGFR2 RUNX2
15 odontogenesis GO:0042476 9.76 BGLAP BMP4 FGFR2
16 positive regulation of bone mineralization GO:0030501 9.75 ACVR1 BMP2 BMP4
17 endoderm development GO:0007492 9.74 BMP4 NOG
18 mesoderm formation GO:0001707 9.74 ACVR1 BMP4 NOG
19 pituitary gland development GO:0021983 9.73 BMP4 NOG
20 telencephalon development GO:0021537 9.73 BMP2 BMP4
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.73 BMP2 BMP4
22 endochondral ossification GO:0001958 9.73 BMP4 RUNX2
23 cardiac muscle cell differentiation GO:0055007 9.73 BMP2 BMP4
24 negative regulation of apoptotic signaling pathway GO:2001234 9.72 GNAI3 NOG
25 anatomical structure formation involved in morphogenesis GO:0048646 9.72 BMP4 NOG
26 regulation of bone mineralization GO:0030500 9.72 ANKH BGLAP
27 lung morphogenesis GO:0060425 9.72 BMP4 NOG
28 osteoblast development GO:0002076 9.71 BGLAP RUNX2
29 positive regulation of cartilage development GO:0061036 9.71 BMP2 BMP4
30 positive regulation of ossification GO:0045778 9.71 BMP2 BMP4
31 regulation of ossification GO:0030278 9.71 ACVR1 RUNX2
32 regulation of osteoblast differentiation GO:0045667 9.71 FGFR2 RUNX2
33 outflow tract septum morphogenesis GO:0003148 9.71 ACVR1 BMP4 FGFR2
34 bone mineralization GO:0030282 9.71 BGLAP BMP2 FGFR2 IBSP
35 smooth muscle cell differentiation GO:0051145 9.7 ACVR1 BMP4
36 mesodermal cell differentiation GO:0048333 9.7 BMP4 FGFR2
37 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 ACVR1 BMP2
38 response to inorganic substance GO:0010035 9.7 BGLAP TNFRSF11B
39 atrioventricular valve morphogenesis GO:0003181 9.69 ACVR1 BMP2
40 embryonic skeletal joint morphogenesis GO:0060272 9.69 BMP4 NOG
41 pharyngeal arch artery morphogenesis GO:0061626 9.69 BMP4 NOG
42 endocardial cushion morphogenesis GO:0003203 9.69 ACVR1 BMP2 NOG
43 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.68 BMP2 RUNX2
44 bud elongation involved in lung branching GO:0060449 9.68 BMP4 FGFR2
45 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
46 regulation of fibroblast growth factor receptor signaling pathway GO:0040036 9.67 FGFR2 RUNX2
47 telencephalon regionalization GO:0021978 9.67 BMP2 BMP4
48 regulation of smooth muscle cell differentiation GO:0051150 9.66 BMP4 FGFR2
49 branching involved in prostate gland morphogenesis GO:0060442 9.65 BMP4 FGFR2
50 prostate gland morphogenesis GO:0060512 9.65 BMP4 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 8.96 BMP2 BMP4
2 BMP receptor binding GO:0070700 8.62 BMP2 BMP4

Sources for Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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35 ICD10 via Orphanet
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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