Aliases & Classifications for Ankylosis

MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 74 44 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD9CM 34 718.5
MeSH 44 D000844
SNOMED-CT 67 36504009
ICD10 32 M24.6
UMLS 71 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to auriculocondylar syndrome 1 and proximal symphalangism, and has symptoms including joint stiffness, arthralgia and metatarsalgia. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Etanercept and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and bone marrow, and related phenotypes are cardiovascular system and craniofacial

Wikipedia : 74 Ankylosis is a stiffness of a joint due to abnormal adhesion and rigidity of the bones of the joint,... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 auriculocondylar syndrome 1 31.8 PLCB4 GNAI3
2 proximal symphalangism 31.7 NOG BMP4 BMP2 ACVR1
3 fibrodysplasia ossificans progressiva 31.7 NOG BMP4 BMP2 ACVR1
4 pfeiffer syndrome 31.4 SP7 RUNX2 NOG FGFR2 FGFR1 CCR6
5 spondyloarthropathy 1 30.9 TNFRSF11B CCR6 BGLAP ANKH
6 myositis ossificans 30.7 BMP4 BGLAP ACVR1
7 hyperostosis 30.7 TNFRSF11B TGFB1 ANKH
8 synostosis 30.6 RUNX2 NOG FGFR2 FGFR1
9 otosclerosis 30.3 TNFRSF11B TGFB1 NOG BMP4 BMP2
10 diffuse idiopathic skeletal hyperostosis 30.3 NOG ENPP1 BMP4 BMP2
11 chondrocalcinosis 30.2 TNFRSF11B ENPP1 ANKH
12 dysostosis 30.2 RUNX2 NOG FGFR2 FGFR1
13 enthesopathy 30.1 ENPP1 CCR6 ANKH
14 familial calcium pyrophosphate deposition 30.0 TNFRSF11B ANKH
15 tooth resorption 29.8 RUNX2 IBSP BMP2 BGLAP
16 calcinosis 29.8 FGFR2 ENPP1 ANKH
17 chromosome 2q35 duplication syndrome 29.7 NOG FGFR2 FGFR1 BMP4 BMP2
18 hypophosphatemia 29.7 FGFR1 ENPP1 BGLAP
19 craniometaphyseal dysplasia, autosomal dominant 29.6 TNFRSF11B SP7 RUNX2 IBSP ENPP1 BGLAP
20 tooth agenesis 29.6 RUNX2 FGFR2 FGFR1 BMP4 BMP2
21 camurati-engelmann disease 29.6 TGFB1 SP7 RUNX2 BGLAP ANKH
22 sclerosteosis 29.6 TGFB1 SP7 RUNX2 NOG BGLAP
23 scoliosis 29.5 TNFRSF11B TGFB1 RUNX2 FGFR2 BMP4 BGLAP
24 cleft palate, isolated 29.5 SP7 RUNX2 NOG IBSP FGFR2 FGFR1
25 osteonecrosis 29.5 TNFRSF11B RUNX2 HIF1A BMP2 BGLAP
26 bone resorption disease 29.5 TNFRSF11B SP7 RUNX2 IBSP CCR6 BMP2
27 connective tissue disease 29.3 RUNX2 IBSP EDN1 CCR6 BGLAP
28 osseous heteroplasia, progressive 29.2 RUNX2 NOG ENPP1 BMP4 BMP2 BGLAP
29 chronic kidney disease 28.9 TNFRSF11B TGFB1 RUNX2 IBSP ENPP1 EDN1
30 osteoporosis 28.6 TNFRSF11B TGFB1 SP7 RUNX2 NOG IBSP
31 permanent molars, secondary retention of 11.7
32 arthropathy 11.6
33 temporomandibular ankylosis 11.6
34 tooth ankylosis 11.6
35 stapes ankylosis with broad thumbs and toes 11.6
36 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 11.3
37 deafness, progressive, with stapes fixation 11.1
38 restrictive dermopathy, lethal 11.0
39 auriculocondylar syndrome 2 11.0
40 congenital temporomandibular joint ankylosis 11.0
41 glossopalatine ankylosis micrognathia ear anomalies 10.9
42 glossopalatine ankylosis 10.9
43 piussan lenaerts mathieu syndrome 10.9
44 multiple synostoses syndrome 10.9
45 pseudoarthrogryposis 10.9
46 distal arthrogryposis 10.9
47 hypoglossia-hypodactylia 10.9
48 symphalangism, proximal, 1a 10.9
49 syngnathia 10.9
50 symphalangism, distal 10.8

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


joint stiffness, arthralgia, metatarsalgia, joint symptom

MGI Mouse Phenotypes related to Ankylosis:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 ACVR1 ANKH BMP2 BMP4 EDN1 ENPP1
2 craniofacial MP:0005382 10.47 ACVR1 ANKH BMP2 BMP4 EDN1 ENPP1
3 growth/size/body region MP:0005378 10.47 ACVR1 ANKH BMP2 BMP4 EDN1 ENPP1
4 homeostasis/metabolism MP:0005376 10.47 ACVR1 ANKH BGLAP BMP2 BMP4 CCR6
5 cellular MP:0005384 10.45 ACVR1 ANKH BGLAP BMP2 BMP4 ENPP1
6 immune system MP:0005387 10.4 ACVR1 ANKH BGLAP BMP2 CCR6 ENPP1
7 hematopoietic system MP:0005397 10.39 ANKH BGLAP BMP2 BMP4 CCR6 FGFR1
8 mortality/aging MP:0010768 10.36 ACVR1 ANKH BMP2 BMP4 EDN1 ENPP1
9 hearing/vestibular/ear MP:0005377 10.34 ACVR1 ANKH BMP2 BMP4 EDN1 ENPP1
10 digestive/alimentary MP:0005381 10.33 ACVR1 BMP2 BMP4 EDN1 FGFR1 FGFR2
11 endocrine/exocrine gland MP:0005379 10.32 BGLAP BMP4 EDN1 FGFR1 FGFR2 HIF1A
12 limbs/digits/tail MP:0005371 10.31 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
13 embryo MP:0005380 10.28 ACVR1 BMP2 BMP4 EDN1 FGFR1 FGFR2
14 nervous system MP:0003631 10.25 ACVR1 BMP2 BMP4 CCR6 EDN1 ENPP1
15 muscle MP:0005369 10.21 ACVR1 ANKH BMP4 EDN1 ENPP1 FGFR1
16 integument MP:0010771 10.16 BMP4 ENPP1 FGFR1 FGFR2 HIF1A NOG
17 liver/biliary system MP:0005370 10.08 BMP4 ENPP1 FGFR2 HIF1A PLCB4 RUNX2
18 normal MP:0002873 10.02 BMP2 BMP4 CCR6 EDN1 FGFR1 FGFR2
19 renal/urinary system MP:0005367 9.97 BMP4 EDN1 ENPP1 FGFR1 FGFR2 HIF1A
20 reproductive system MP:0005389 9.96 ANKH BGLAP BMP2 BMP4 FGFR1 FGFR2
21 skeleton MP:0005390 9.93 ACVR1 ANKH BGLAP BMP2 BMP4 EDN1
22 respiratory system MP:0005388 9.76 ANKH BMP4 FGFR2 HIF1A NOG RUNX2
23 vision/eye MP:0005391 9.36 BMP4 ENPP1 FGFR1 FGFR2 HIF1A NOG

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
2 Anti-Inflammatory Agents Phase 2, Phase 3
3 Analgesics, Non-Narcotic Phase 2, Phase 3
4 Immunosuppressive Agents Phase 2, Phase 3
5 Gastrointestinal Agents Phase 2, Phase 3
6 Immunologic Factors Phase 2, Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
8 Analgesics Phase 2, Phase 3
9 Antirheumatic Agents Phase 2, Phase 3
10 Tea

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
2 Transport Distraction Osteogenesis for Reconstruction of Ramus-Condyle Unit Following Release of Temporomandibular Joint Ankylosis Completed NCT04383964
3 Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot Study Completed NCT02456272
4 CT Follow-Up of the SImmetry Sacroiliac Joint Fusion System Completed NCT02425631
5 Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity. Recruiting NCT03845088
6 Actis Total Hip System 2 Year Follow-up Recruiting NCT02783274
7 Retrospective and Prospective Clinical Outcomes Study of the Zimmer® Nexelâ„¢ Total Elbow Recruiting NCT02469662
8 Study of Validation of Measurements of the Movement of Stiff Treated Teeth and Orthodontic Corticotomy Recruiting NCT02337153
9 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator Cemented Femoral Stems Active, not recruiting NCT02397746
10 Post Market Clinical Follow-up Study Protocol for PROFEMUR® Xm Femoral Stems Active, not recruiting NCT02309593
11 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator HA Coated Modular Femoral Stems Active, not recruiting NCT02314611
12 Evolusion Study Using the Zyga SImmetry Sacroiliac Joint Fusion System Active, not recruiting NCT02074761
13 Post Market Clinical Follow-up Study Protocol for DYNASTY® BioFoam® Acetabular Components Enrolling by invitation NCT02149667
14 Post Market Clinical Follow-Up Study Protocol for CONSERVE® Press-Fit Femoral Components Enrolling by invitation NCT02285842
15 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® TL Modular Femoral Stems Enrolling by invitation NCT02239783
16 Post Market Clinical Follow-up Study Protocol for PROFEMUR® Gladiator Plasma Femoral Stems and PROCOTYL® L Beaded Acetabular Components Enrolling by invitation NCT02823834
17 Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem Enrolling by invitation NCT04147559
18 The Use of Proximal Carpal Row Versus Iliac Crest Bone Graft in Total Wrist Fusion - a Randomized Controlled Multicenter Trial Comparing Two Operative Techniques (PROOF II - Trial) Not yet recruiting NCT04403958
19 SI Joint Fusion and Decortication Using the SImmetry System Terminated NCT02560714
20 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Am Femoral Components and PROCOTYL® O HA Coated Acetabular Components Withdrawn NCT02507258

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

40
Bone, Spinal Cord, Bone Marrow, Skin, T Cells, Endothelial, Tongue

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 4663)
# Title Authors PMID Year
1
Effect of root surface treatment with denusomab after delayed tooth replantation. 61
32728940 2021
2
Abdominal Dermis-Fat Graft Versus Conventional Temporalis Myofascial Flap Interposition in Temporomandibular Joint Ankylosis: A Prospective Clinical Comparative Study. 61
33584043 2021
3
Quality of life after distraction osteogenesis in TMJ ankylosis patients. 61
33187947 2021
4
Development and evolution of the notarium in Pterosauria. 61
33026119 2021
5
Noninvasive Management of Pediatric Isolated, Condylar Fractures: Less Is More? 61
33565828 2021
6
MRI-based Synthetic CT in the Detection of Structural Lesions in Patients with Suspected Sacroiliitis: Comparison with MRI. 61
33350891 2021
7
Temporomandibular Joint Ankylosis Surgery in Children. 61
33137301 2021
8
The risks of ankylosis of 89 avulsed human teeth stored in saliva prior to replantation-A re-evaluation of a long-term clinical study. 61
33527633 2021
9
Orthodontic treatment of open bite involved in diffuse hypercementosis: A case report. 61
33203553 2021
10
Cell-based therapy for tooth replantation following avulsion: A systematic review. 61
33593127 2021
11
The effect of soy and whole milk as a means to store avulsed teeth: A histometric study. 61
32813934 2021
12
First two cases of severe type 2 respiratory failure associated with diffuse idiopathic skeletal hyperostosis. 61
33550773 2021
13
Junctional Failures after Thoracolumbar Kyphosis Correction in Patients with Ankylosing Spondylitis. 61
33556596 2021
14
Mid-term results of bilateral synchronous total hip arthroplasty for bony ankylosis in patients with ankylosing spondylitis. 61
33531039 2021
15
Using internet search data to explore the global public concerns in ankylosing spondylitis. 61
32094142 2021
16
Is the Conductive Hearing Loss in NOG-Related Symphalangism Spectrum Disorder Congenital? 61
33588412 2021
17
Psoriatic arthritis associated with peliosis hepatis: characteristics and therapeutic management. 61
33598810 2021
18
A single-stage computer-guided gap arthroplasty with simultaneous patient-specific total joint replacement with a novel flat fossa design: A case report. 61
33529825 2021
19
A retrospective analysis of the optimal time and psychological impact of decoronation in children and adolescents. 61
33411972 2021
20
Heterotopic Ossification After Elbow Fractures. 61
33238018 2021
21
Bone pathologies of modern non-draft cattle (Bos Taurus) in the context of grazing systems and environmental influences in the South Urals, Russia. 61
33494025 2021
22
Impact of technology in temporomandibular joint reconstruction surgeries: A systematic review. 61
33597084 2021
23
A new method for individual condylar osteotomy and repositioning guides used in patients with severe deformity secondary to condylar osteochondroma. 61
33516245 2021
24
Retro-Auricular Approach to the Fractures of the Mandibular Condyle: A Systematic Review. 61
33440626 2021
25
Reconstruction of Bilateral Mandibular Condyles Using a Single Vascularized Fibula. 61
33552802 2021
26
Long-Term Retention of Avulsed Maxillary Incisors with Replacement Root Resorption: A 9-Year Follow-Up. 61
33505733 2021
27
The Application of Intraoperative Computed Tomography in Surgical Management of Temporomandibular Joint Ankylosis. 61
33010216 2021
28
Computer-guided gap arthroplasty: a new approach to the execution of preplanned osteotomies for the treatment of bony ankylosis of the temporomandibular joint. 61
33208285 2021
29
Re: Computer-guided gap arthroplasty: a new approach to the execution of preplanned osteotomies for the treatment of bony ankylosis of the temporomandibular joint. 61
33208289 2021
30
Induction, Treatment, and Prevention of Temporomandibular Joint Ankylosis-A Systematic Review of Comparative Animal Studies. 61
32800758 2021
31
The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle. 61
33415516 2021
32
Arthrofibrosis after total knee arthroplasty: patients with keloids at risk. 61
33403515 2021
33
Complication After Mandibular Reconstruction With Fibula Free Flap in a Patient With Hemifacial Microsomia. 61
33405458 2021
34
Retrospective Evaluation of Immediate Impacted Third Molars Autotransplantation After Extractions of Mandibular First and/or Second Molars With Chronic Periapical Lesions. 61
32926867 2021
35
Post-traumatic spinal hematoma in ankylosing spondylitis. 61
33452963 2021
36
Total ankylosis of the bilateral hand and wrist joints in a patient with ankylosing spondylitis. 61
32927939 2021
37
Outcome of Stock Total Joint Replacement With Fat Grafting in Adult Temporomandibular Joint Ankylosis Patients. 61
32866483 2021
38
Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis. 61
33435178 2021
39
Computer-guided implant placement in contact with root remnants in the esthetic area. 61
33433079 2021
40
Traumatic Posterior Dislocation of Bilateral Mandible Condyles into External Auditory Canal Treated with Midline Mandibulotomy: A Rare Case Report and Review of Literature. 61
33071515 2020
41
Ablation of Pyrophosphate Regulators Promotes Periodontal Regeneration. 61
33356859 2020
42
Geomorphologic study of human tooth root surfaces following simulated avulsion by scanning electron microscopy. 61
33369075 2020
43
Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition. 61
33328503 2020
44
Surgical correction of ankylosed TMJ in a child: case report. 61
32572708 2020
45
Comparison of unilateral rostral, middle and caudal segmental mandibulectomies as an alternative treatment for unilateral temporomandibular joint ankylosis in cats: an ex vivo study. 61
33289444 2020
46
The Stress Concentration and Biomechanical Properties of the Intra-oral Distractors and the Extra-oral Distractors Used in Treatment of Post Ankylosis Facial Asymmetric Patients: A Finite Element Analysis Study. 61
33306641 2020
47
Asymmetric midshaft femur remodeling in an adult male with left sided hip joint ankylosis, Metal Period Nagsabaran, Philippines. 61
32877865 2020
48
The dietary behavior of two early medieval individuals with temporomandibular ankylosis. 61
32805633 2020
49
Surgical and Orthodontic Approach to Temporomandibular Joint Ankylosis After Ear Infection: A Case Series. 61
32649895 2020
50
Patellofemoral ankylosis: case report and technical note. 61
32361953 2020

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 TGFB1 PLCB4 HIF1A GNAI3 FGFR2 FGFR1
2
Show member pathways
13.56 TNFRSF11B TGFB1 PLCB4 GNAI3 FGFR2 FGFR1
3
Show member pathways
13.32 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 CCR6
4
Show member pathways
13.28 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
5
Show member pathways
13.24 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
6
Show member pathways
13.23 TGFB1 PLCB4 FGFR2 FGFR1 CCR6 BMP4
7
Show member pathways
13.01 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
8
Show member pathways
12.97 TGFB1 HIF1A GNAI3 FGFR2 FGFR1 BMP4
9
Show member pathways
12.82 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 EDN1
10
Show member pathways
12.67 TGFB1 FGFR2 FGFR1 BMP4 BMP2
11
Show member pathways
12.46 TGFB1 NOG FGFR1 BMP4 ACVR1
12
Show member pathways
12.37 TGFB1 FGFR2 FGFR1 BMP4 BMP2
13 12.33 TGFB1 PLCB4 HIF1A GNAI3 FGFR2 FGFR1
14
Show member pathways
12.23 TGFB1 FGFR2 FGFR1 BMP4 BMP2
15
Show member pathways
12.14 TGFB1 NOG GNAI3 FGFR2 BMP4 BMP2
16 12.07 FGFR2 FGFR1 BMP4 ACVR1
17 12.01 TGFB1 HIF1A BMP4 BMP2
18 11.85 TGFB1 PLCB4 EDN1
19 11.79 TGFB1 HIF1A FGFR2 FGFR1
20 11.75 FGFR1 BMP4 BMP2
21 11.74 RUNX2 PLCB4 GNAI3 FGFR1 BGLAP
22
Show member pathways
11.71 TGFB1 BMP4 BMP2
23
Show member pathways
11.7 RUNX2 NOG BMP2
24 11.7 TGFB1 FGFR2 FGFR1 BMP4 BMP2
25 11.68 HIF1A FGFR2 FGFR1
26 11.67 PLCB4 GNAI3 EDN1
27 11.63 TGFB1 NOG BMP4 BMP2 ACVR1
28 11.62 TGFB1 RUNX2 FGFR1 ENPP1
29 11.54 TGFB1 NOG BMP4
30 11.52 TGFB1 RUNX2 NOG BMP4
31 11.49 RUNX2 HIF1A BGLAP
32 11.49 TGFB1 NOG BMP4
33 11.46 TNFRSF11B RUNX2 BGLAP
34 11.41 RUNX2 FGFR2 FGFR1 BGLAP
35 11.35 TGFB1 RUNX2 IBSP BGLAP
36 11.26 RUNX2 PLCB4 IBSP BGLAP
37 11.15 TGFB1 SP7 RUNX2 NOG BMP4 BMP2
38 10.96 TGFB1 GNAI3 FGFR2 FGFR1 BMP4 BMP2
39 10.82 TNFRSF11B IBSP BGLAP

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNFRSF11B TGFB1 NOG IBSP ENPP1 EDN1
2 integral component of plasma membrane GO:0005887 9.8 SLC20A2 FGFR2 FGFR1 ENPP1 CCR6 ANKH
3 extracellular region GO:0005576 9.36 TNFRSF11B TGFB1 NOG IBSP FGFR2 FGFR1
4 BMP receptor complex GO:0070724 8.96 BMP2 ACVR1

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.24 TGFB1 NOG FGFR2 EDN1 BMP4 BMP2
2 positive regulation of transcription, DNA-templated GO:0045893 10.21 TGFB1 RUNX2 HIF1A BMP4 BMP2 ACVR1
3 positive regulation of cell proliferation GO:0008284 10.17 TGFB1 RUNX2 FGFR2 FGFR1 EDN1 BMP4
4 positive regulation of gene expression GO:0010628 10.14 TGFB1 RUNX2 NOG HIF1A BMP4 BMP2
5 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 TGFB1 SP7 RUNX2 NOG HIF1A FGFR2
6 negative regulation of gene expression GO:0010629 10.08 TGFB1 NOG HIF1A EDN1 BMP4 BMP2
7 angiogenesis GO:0001525 10.06 HIF1A FGFR2 BMP4 ACVR1
8 positive regulation of cell migration GO:0030335 10.06 TGFB1 EDN1 BMP4 BMP2 ACVR1
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.05 TGFB1 FGFR2 BMP4 BMP2
10 heart development GO:0007507 10.04 TGFB1 EDN1 BMP4 BMP2 ACVR1
11 response to hypoxia GO:0001666 10.03 TGFB1 HIF1A EDN1 BMP2
12 in utero embryonic development GO:0001701 10.03 NOG FGFR2 EDN1 BMP2 ACVR1
13 positive regulation of neuron differentiation GO:0045666 9.94 FGFR1 BMP4 BMP2
14 neural tube closure GO:0001843 9.94 TGFB1 NOG BMP4
15 positive regulation of endothelial cell proliferation GO:0001938 9.93 HIF1A BMP4 BMP2
16 cell fate commitment GO:0045165 9.93 FGFR2 BMP4 BMP2
17 negative regulation of epithelial cell proliferation GO:0050680 9.92 TGFB1 FGFR2 BMP4
18 SMAD protein signal transduction GO:0060395 9.92 TGFB1 BMP4 BMP2
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 FGFR2 EDN1 BMP4
20 positive regulation of osteoblast differentiation GO:0045669 9.92 RUNX2 BMP4 BMP2 ACVR1
21 positive regulation of epithelial cell proliferation GO:0050679 9.92 TGFB1 NOG FGFR2 BMP4
22 cellular response to transforming growth factor beta stimulus GO:0071560 9.91 TGFB1 FGFR2 EDN1
23 positive regulation of MAP kinase activity GO:0043406 9.91 TGFB1 FGFR1 EDN1
24 bone development GO:0060348 9.91 FGFR2 BMP4 BGLAP
25 odontogenesis of dentin-containing tooth GO:0042475 9.91 TGFB1 RUNX2 BMP4 BMP2
26 ossification GO:0001503 9.91 RUNX2 IBSP BMP4 BMP2 BGLAP
27 negative regulation of cell cycle GO:0045786 9.9 TGFB1 BMP4 BMP2
28 regulation of cell differentiation GO:0045595 9.9 RUNX2 FGFR1 BMP4
29 positive regulation of blood vessel endothelial cell migration GO:0043536 9.9 TGFB1 HIF1A FGFR1
30 outflow tract morphogenesis GO:0003151 9.9 NOG HIF1A BMP4
31 positive regulation of epithelial to mesenchymal transition GO:0010718 9.89 TGFB1 BMP4 BMP2
32 positive regulation of cell differentiation GO:0045597 9.89 FGFR1 BMP4 BMP2
33 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.89 TGFB1 BMP4 BMP2 ACVR1
34 skeletal system morphogenesis GO:0048705 9.88 RUNX2 FGFR2 FGFR1
35 bone mineralization GO:0030282 9.88 IBSP FGFR2 BMP2 BGLAP
36 dorsal/ventral pattern formation GO:0009953 9.87 NOG EDN1 ACVR1
37 lung alveolus development GO:0048286 9.87 TGFB1 FGFR2 BMP4
38 odontogenesis GO:0042476 9.87 FGFR2 BMP4 BGLAP
39 chondrocyte differentiation GO:0002062 9.87 TGFB1 RUNX2 BMP4 BMP2
40 biomineral tissue development GO:0031214 9.86 IBSP ENPP1 BGLAP
41 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.86 TGFB1 HIF1A BMP4 BMP2
42 embryonic cranial skeleton morphogenesis GO:0048701 9.85 RUNX2 FGFR2 BMP4
43 mesoderm formation GO:0001707 9.85 NOG BMP4 ACVR1
44 ureteric bud development GO:0001657 9.85 TGFB1 NOG FGFR2 BMP4
45 cartilage development GO:0051216 9.85 NOG HIF1A EDN1 BMP4 BMP2
46 BMP signaling pathway GO:0030509 9.85 TGFB1 RUNX2 NOG BMP4 BMP2 ACVR1
47 endoderm development GO:0007492 9.84 TGFB1 NOG BMP4
48 outflow tract septum morphogenesis GO:0003148 9.83 FGFR2 BMP4 ACVR1
49 positive regulation of bone mineralization GO:0030501 9.83 TGFB1 BMP4 BMP2 ACVR1
50 regulation of bone mineralization GO:0030500 9.81 ENPP1 BGLAP ANKH

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 9.32 BMP4 BMP2
2 co-receptor binding GO:0039706 9.26 BMP4 BMP2
3 inorganic phosphate transmembrane transporter activity GO:0005315 9.16 SLC20A2 ANKH
4 cytokine activity GO:0005125 9.02 TNFRSF11B TGFB1 EDN1 BMP4 BMP2
5 fibroblast growth factor-activated receptor activity GO:0005007 8.96 FGFR2 FGFR1

Sources for Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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