Aliases & Classifications for Ankylosis

MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 76 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:227
ICD10 33 M24.6
ICD9CM 35 718.5 718.50
MeSH 44 D000844
SNOMED-CT 68 36504009
UMLS 73 C0003090

Summaries for Ankylosis

Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to fibrodysplasia ossificans progressiva and auriculocondylar syndrome 1, and has symptoms including joint stiffness, arthralgia and metatarsalgia. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Sulfasalazine and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related phenotypes are Decreased IL-13 protein expression and cardiovascular system

Wikipedia : 76 Ankylosis or anchylosis (from Greek �?γκύλο�?, bent, crooked) is a stiffness of a joint due to abnormal... more...

Related Diseases for Ankylosis

Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 fibrodysplasia ossificans progressiva 32.0 ACVR1 BMP4 NOG
2 auriculocondylar syndrome 1 31.7 GNAI3 PLCB4
3 proximal symphalangism 31.5 BMP4 NOG
4 pfeiffer syndrome 31.2 BGLAP FGFR2 RUNX2 SP7
5 craniometaphyseal dysplasia, autosomal dominant 29.9 ACVR1 ANKH SP7
6 otosclerosis 29.4 BMP2 BMP4 NOG TNFRSF11B
7 periodontitis 29.2 BGLAP RUNX2 TNFRSF11B
8 osseous heteroplasia, progressive 29.0 ACVR1 BGLAP BMP2 BMP4 NOG RUNX2
9 osteoporosis 28.1 BGLAP BMP2 BMP4 IBSP NOG RUNX2
10 tooth ankylosis 12.6
11 stapes ankylosis with broad thumbs and toes 12.5
12 temporomandibular ankylosis 12.5
13 permanent molars, secondary retention of 12.3
14 congenital temporomandibular joint ankylosis 12.1
15 glossopalatine ankylosis 12.1
16 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 12.0
17 glossopalatine ankylosis micrognathia ear anomalies 12.0
18 arthropathy 12.0
19 cardiocranial syndrome 11.7
20 spondyloarthropathy 1 11.4
21 piussan lenaerts mathieu syndrome 11.3
22 syngnathia 11.3
23 deafness, progressive, with stapes fixation 11.1
24 restrictive dermopathy, lethal 11.1
25 auriculocondylar syndrome 2 11.1
26 pseudoarthrogryposis 11.0
27 distal arthrogryposis 11.0
28 johnson hall krous syndrome 11.0
29 hypoglossia-hypodactylia 11.0
30 symphalangism, distal 11.0
31 symphalangism, proximal, 1a 11.0
32 auriculocondylar syndrome 3 11.0
33 multiple synostoses syndrome 11.0
34 charlie m syndrome 11.0
35 arthritis 10.6
36 spondylitis 10.5
37 rheumatoid arthritis 10.4
38 hemifacial hyperplasia 10.2
39 root resorption 10.2
40 septic arthritis 10.2
41 noma 10.2
42 humeroradial synostosis 10.2 FGFR2 NOG
43 auriculo-condylar syndrome 10.2 GNAI3 PLCB4
44 psoriatic arthritis 10.2
45 spondyloarthropathy 10.2
46 hyperostosis 10.1
47 bone fracture 10.1 BGLAP BMP2
48 sleep apnea 10.1
49 synostosis 10.1
50 osteochondroma 10.1

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis

Symptoms & Phenotypes for Ankylosis

UMLS symptoms related to Ankylosis:


joint stiffness, arthralgia, metatarsalgia, joint symptom

GenomeRNAi Phenotypes related to Ankylosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-13 protein expression GR00219-A 8.62 ACVR1 FGFR2

MGI Mouse Phenotypes related to Ankylosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.19 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3
2 cellular MP:0005384 10.18 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
3 growth/size/body region MP:0005378 10.18 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
4 craniofacial MP:0005382 10.16 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
5 homeostasis/metabolism MP:0005376 10.06 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3
6 digestive/alimentary MP:0005381 10.04 ACVR1 BMP2 BMP4 FGFR2 IBSP NOG
7 hematopoietic system MP:0005397 10.03 ANKH BMP2 BMP4 FGFR2 GNAI3 IBSP
8 limbs/digits/tail MP:0005371 10.02 ACVR1 ANKH BMP2 BMP4 FGFR2 IBSP
9 hearing/vestibular/ear MP:0005377 10 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
10 immune system MP:0005387 9.97 ACVR1 ANKH BMP2 FGFR2 GNAI3 IBSP
11 mortality/aging MP:0010768 9.96 ACVR1 ANKH BMP2 BMP4 FGFR2 NOG
12 muscle MP:0005369 9.7 ACVR1 ANKH BMP4 FGFR2 NOG PLCB4
13 respiratory system MP:0005388 9.43 ANKH BMP4 FGFR2 NOG RUNX2 SP7
14 skeleton MP:0005390 9.4 ACVR1 ANKH BMP2 BMP4 FGFR2 GNAI3

Drugs & Therapeutics for Ankylosis

Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1 599-79-1 5353980 5359476
2
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 185243-69-0
3
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
4
Adalimumab Approved Phase 4,Phase 2,Phase 3,Not Applicable 331731-18-1 16219006
5
Pamidronate Approved Phase 4 40391-99-9 4674
6
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
7
Infliximab Approved Phase 4,Phase 3,Phase 1,Not Applicable 170277-31-3
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 59-05-2, 1959-05-2 126941
9
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 6006 143
10
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
13
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3 302-25-0
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3 2921-57-5
15
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
16
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
17
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
18
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Aceclofenac Approved, Investigational Phase 4 89796-99-6
21
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
22
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 54677470 5281106
23
Indomethacin Approved, Investigational Phase 4,Phase 3 53-86-1 3715
24
Hydroxychloroquine Approved Phase 4 118-42-3 3652
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
26
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3 2920-86-7
27 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Not Applicable
29 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Immunosuppressive Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Not Applicable
32 Cyclooxygenase 2 Inhibitors Phase 4,Phase 3,Not Applicable
33 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
34 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
36 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
37 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
39 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Natriuretic Agents Phase 4
41 Natriuretic Peptide, Brain Phase 4
42 Vitamin B9 Phase 4,Phase 3,Phase 2
43 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
45 Vitamin B Complex Phase 4,Phase 3,Phase 2
46 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
47 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
48 Folate Phase 4,Phase 3,Phase 2
49 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
50 Prednisolone acetate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 360)
# Name Status NCT ID Phase Drugs
1 Gait Analysis of Ankle Arthroplasty and Arthrodesis Unknown status NCT00921076 Phase 4
2 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
3 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
4 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
5 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
6 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
7 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Completed NCT03190603 Phase 4 Celecoxib
8 A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis Completed NCT01162421 Phase 4 Methotrexate
9 Prevention of Heterotopic Ossification With Arcoxia After Total Hip Replacement Completed NCT01022190 Phase 4 Etoricoxib (Arcoxia)
10 Efficacy and Safety of Etanercept in Active RA Despite Methotrexate Therapy in Japan Completed NCT00688103 Phase 4 ETN Alone;ETN+MTX
11 A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies. Completed NCT00462345 Phase 4 rituximab;Methotrexate;Corticosteroid or NSAID
12 CAMEO: Canadian Methotrexate and Etanercept Outcome Study Completed NCT00654368 Phase 4 Methotrexate
13 A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis. Completed NCT00502853 Phase 4 rituximab [MabThera/Rituxan];Methotrexate
14 A Pilot Study of the Feasibility of Discontinuation of Adalimumab in Stable Rheumatoid Arthritis Patients in Clinical Remission Completed NCT00808509 Phase 4 methotrexate
15 Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis Completed NCT03800797 Phase 4 Loxoprofen sodium hydrogel patch;Loxoprofen sodium tablet
16 Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study Completed NCT02915354 Phase 4 Etanercept
17 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4 Celecoxib 200 milligrams;Celecoxib 400 milligrams;diclofenac 50 milligrams
18 Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Active Ankylosing Spondylitis Completed NCT01934933 Phase 4 celebrex;Enbrel;Enbrel plus Celebrex
19 Effect of the Combination of Methotrexate and Adalimumab on Reduction of Immunization in Ankylosing Spondylitis (COMARIS) Completed NCT01895764 Phase 4 Adalimumab;Methotrexate
20 The Incidence of Extra-Articular Manifestations in Participants With Ankylosing Spondylitis Treated With Golimumab (MK-8259-012) Completed NCT01668004 Phase 4
21 Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy Completed NCT01517620 Phase 4 Total Glucosides Paeony Capsules
22 Effect of Anti-TNF (Alpha) Treatment on Vascular Stiffness in Ankylosing Spondylitis (AS) Completed NCT01212653 Phase 4 Simponi
23 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
24 Efficacy and Safety of Kunxian Capsule in Treatment Patients With Early Ankylosing Spondylitis Completed NCT00953979 Phase 4 kunxian capsule
25 Efficacy and Safety Study of Infliximab (Remicade) to Treat Early Ankylosing Spondylitis Completed NCT00936143 Phase 4 infliximab
26 Study Evaluating Etanercept in Subjects With Ankylosing Spondylitis in Spain Completed NCT00873730 Phase 4 etanercept;etanercept/placebo
27 Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED) Completed NCT00779935 Phase 4
28 A Study of the Efficacy and Tolerance of Remicade in the Treatment of Active Ankylosing Spondylitis (Study P04042)(COMPLETED) Completed NCT00779012 Phase 4
29 Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED) Completed NCT00778869 Phase 4
30 Effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) on RAdiographic Damage in Ankylosing Spondylitis Completed NCT00715091 Phase 4 diclophenac;diclophenac
31 Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis Completed NCT00647517 Phase 4 Ultracet
32 Infliximab and Methotrexate in Ankylosing Spondylitis Completed NCT00507403 Phase 4 infliximab
33 Study Evaluating Etanercept in Patients With Ankylosing Spondylitis Completed NCT00458185 Phase 4 etanercept
34 An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis Completed NCT00444340 Phase 4 Enbrel (Etanercept)
35 Combination Methotrexate and Infliximab Completed NCT00432432 Phase 4 Infliximab and MTX
36 Study Evaluating Etanercept for the Treatment of Active, Severe, and Advanced Axial Ankylosing Spondylitis Completed NCT00420238 Phase 4 Etanercept (Enbrel)
37 Extension Study Evaluating Etanercept in Ankylosing Spondylitis Completed NCT00410046 Phase 4 Enbrel (etanercept)
38 Study Evaluating Etanercept and Sulphasalazine in Ankylosing Spondylitis Completed NCT00247962 Phase 4 etanercept;sulphasalazine (SSZ)
39 TNFalfa Blocking Treatment of Spondylarthropathies Completed NCT00133315 Phase 4 Infliximab;Etanercept;Adalimumab
40 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
41 Treat-to-target With Secukinumab in Axial Spondyloarthritis Recruiting NCT03639740 Phase 4 Secukinumab 150 milligram [Cosentyx]
42 Non-Steroidal Anti-inflammatory Drugs in Axial Spondyloarthritis Recruiting NCT03473665 Phase 4 Indomethacin;Diclofenac;Meloxicam;Celecoxib
43 Sequential Application of Yisaipu® and DMARDs in Treating Mild-to-Moderate AS Recruiting NCT03411798 Phase 4 Yisaipu®
44 Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis Recruiting NCT03350815 Phase 4 150 mg open-label secukinumab;150 mg double-blinded secukinumab;300 mg double-blinded secukinumab
45 A Randomized, Double-blind, Placebo-controlled Multicenter Study of Secukinumab (AIN457) to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis Recruiting NCT02763046 Phase 4 AIN457/Secukinumab Placebo
46 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Recruiting NCT02634541 Phase 4 Adalimumab
47 Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients Recruiting NCT02492217 Phase 4 Adalimumab
48 NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis Active, not recruiting NCT02758782 Phase 4 Celecoxib
49 Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA Active, not recruiting NCT02509026 Phase 4
50 A Study of Golimumab in the Treatment of Indian Participants With Active Spondyloarthropathy of Ankylosing Spondylitis or Psoriatic Arthritis Not yet recruiting NCT03733925 Phase 4 Golimumab

Search NIH Clinical Center for Ankylosis

Cochrane evidence based reviews: ankylosis

Genetic Tests for Ankylosis

Anatomical Context for Ankylosis

MalaCards organs/tissues related to Ankylosis:

41
Bone, Skin, Spinal Cord, Brain, Spleen, Tonsil, Heart

Publications for Ankylosis

Articles related to Ankylosis:

(show top 50) (show all 1021)
# Title Authors Year
1
Clinical experience in managing temporomandibular joint ankylosis: five-year appraisal in a Nigerian subpopulation. ( 29963492 )
2018
2
Temporomandibular Joint Ankylosis: Algorithm of Treatment. ( 29509170 )
2018
3
Autogenous Dermis-fat Graft in Temporomandibular Joint Ankylosis Surgery. ( 29963448 )
2018
4
Evaluation of Hemoglobin Concentration and Hematocrit Values in Temporomandibular Joint Ankylosis Patients in Comparison to Nonankylosed Patients. ( 29422472 )
2018
5
Retrograde intubation in a dog with severe temporomandibular joint ankylosis: case report. ( 29587754 )
2018
6
Protocol for Single-Stage Bilateral Temporomandibular Joint Replacement Using Intraoperative Navigation in Patients With Ankylosis. ( 29530748 )
2018
7
The First Record of Incidences of Ankylosis in Seven Triplefin Fishes (Pisces: Tripterygiidae) from New Zealand. ( 29059718 )
2018
8
Temporomandibular Joint Ankylosis: "A Pediatric Difficult Airway Management". ( 29628599 )
2018
9
Coexistence of Ankylosing Spondylitis and Myotonic Dystrophy: Camptocormia or Thoracic Ankylosis. ( 29465620 )
2018
10
Traumatic Bony Ankylosis of Temporomandibular Joint as a Complication After Reduction Malarplasty. ( 29554062 )
2018
11
Use of Kerrison Rongeur for safe and effective removal of bone in temporomandibular joint ankylosis. ( 29340886 )
2018
12
Augmentation surgery on the cartilaginous portion of the vocal fold in a patient with cricoarytenoid joint ankylosis. ( 29307442 )
2018
13
Management of Temporomandibular Joint Ankylosis With Dentofacial Deformities in Children. ( 29381640 )
2018
14
A Bone Conduction Implantable Device as a Functional Treatment Option in Unilateral Microtia with Bilateral Stapes Ankylosis: A Report of Two Cases. ( 29358571 )
2018
15
Orthognathic treatment of facial asymmetry due to temporomandibular joint ankylosis. ( 29076326 )
2018
16
Extra-Articular Ankylosis of the Coronoid Process With the Zygomatic Bone: A Rare Case Treated With an Alternative Approach. ( 29742575 )
2018
17
Endoscopically Assisted Transoral Gap Arthroplasty of the Temporomandibular Joint Ankylosis in a Pediatric Patient. ( 29742569 )
2018
18
Surgical treatment of hip ankylosis due to heterotopic ossification secondary to spinal cord injury. ( 29477350 )
2018
19
Zygomatico-coronoid Ankylosis as Sequel of Inadequate Treatment. ( 29963447 )
2018
20
Concomitant Temporomandibular Joint Ankylosis and Maxillomandibular Fusion in a Child with Klippel-Feil Syndrome: A Case Report. ( 29763351 )
2018
21
Preserving the Fibrous Layer of the Mandibular Condyle Reduces the Risk of Ankylosis in a Sheep Model of Intracapsular Condylar Fracture. ( 29908889 )
2018
22
Monitoring of incremental changes in maximum interincisal opening after gap arthroplasty omits the risk of Re-ankylosis. ( 29037918 )
2018
23
A New Method of Treatment of Temporomandibular Joint Ankylosis with Osteodistraction Using the Sh-Device: A Case Report. ( 29971123 )
2018
24
Cricoarytenoid Joint Ankylosis: Classification and Transoral Laser Microsurgical Treatment. ( 29306525 )
2018
25
The sequential treatment of temporomandibular joint ankylosis with secondary deformities by distraction osteogenesis and arthroplasty or TMJ reconstruction. ( 29706239 )
2018
26
Double non-contiguous fractures in a patient with spondylo-epiphyseal dysplasia with spinal ankylosis treated with open and percutaneous spinal fixation technique: a case report. ( 29415765 )
2018
27
Temporomandibular Joint Ankylosis After Ramus Construction With Free Fibula Flaps in Children With Hemifacial Microsomia. ( 29852140 )
2018
28
Change in the posterior airway after mandibular distraction osteogenesis in patients with ankylosis of the temporomandibular joint: a retrospective study. ( 29887252 )
2018
29
Bilateral total mandibular reconstruction with patient specific implants for temporomandibular joint ankylosis. ( 29777779 )
2018
30
Grafts of autogenous coronoid process to reconstruct the mandibular condyle in children with unilateral ankylosis of the temporomandibular joint: long-term effects on mandibular growth. ( 29254874 )
2018
31
Interpositional Arthroplasty by Temporalis Fascia Flap and Galea Aponeurotica Combined With Distraction Osteogenesis: a Modified Method in Treatment of Adult Patients With Temporomandibular Joint Ankylosis and Mandibular Dysplasia. ( 29303852 )
2018
32
Delayed tooth reimplantation with 4-year follow-up: the management of ankylosis during facial growth. ( 29714701 )
2018
33
A case of localized cervical bony ankylosis due to ulcerative colitis. ( 30071932 )
2018
34
Accuracy of Virtual Surgical Planning in Treatment of Temporomandibular Joint Ankylosis Using Distraction Osteogenesis: Comparison of Planned and Actual Results. ( 30092217 )
2018
35
The surgical management of extra-articular ankylosis in noma patients. ( 30104131 )
2018
36
Alternate technique of exchanging nasotracheal tube in a case of temporomandibular joint ankylosis. ( 30104857 )
2018
37
Persistent stapedial artery with ankylosis of the stapes footplate. ( 30138512 )
2018
38
Condyle-preserved arthroplasty versus costochondral grafting in paediatric temporomandibular joint ankylosis: a retrospective investigation. ( 30145062 )
2018
39
Versatility of uniplanar prearthoplastic distraction osteogenesis in the correction of post-ankylosis facial deformities-a report of five different cases. ( 30203137 )
2018
40
Pre-arthroplastic mandibular distraction osteogenesis for the correction of OSA in TMJ ankylosis: a prospective observational study of 25 cases. ( 30255279 )
2018
41
Sacroiliac Joint Ankylosis In Young Spondyloarthritis Patients Receiving Biologic Therapy: Observation of Serial MRI scans. ( 30295426 )
2018
42
Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia. ( 30356088 )
2018
43
Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis. ( 30408613 )
2018
44
Ankylosis of the Coronoid Process to the Zygomatic Bone: A Case Report and Review of the Literature. ( 30439329 )
2018
45
Post-infectious ankylosis of the cervical spine in an army veteran: a case report. ( 30450191 )
2018
46
Role of extra oral monofocal distractor device in the correction of the facial asymmetry, sleep apnoea, and quality of life associated with TMJ ankylosis. ( 30513389 )
2018
47
Infraclavicular catheter as an aid to physiotherapy in postoperative patients of elbow ankylosis. ( 30532335 )
2018
48
Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study. ( 29016762 )
2017
49
Micrognathia with temporomandibular joint ankylosis and obstructive sleep apnea treated with mandibular distraction osteogenesis using skeletal anchorage: a case report. ( 29126455 )
2017
50
Multidisciplinary management of post-ankylosis malocclusion and mandibular deformity. ( 29364827 )
2017

Variations for Ankylosis

Expression for Ankylosis

Search GEO for disease gene expression data for Ankylosis.

Pathways for Ankylosis

Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
2
Show member pathways
13.15 ACVR1 BMP2 BMP4 FGFR2 GNAI3 PLCB4
3
Show member pathways
12.8 BMP2 BMP4 FGFR2 GNAI3 PLCB4
4 12.6 BMP2 BMP4 FGFR2 GNAI3 PLCB4
5 11.89 BMP4 FGFR2 TNFRSF11B
6 11.87 ACVR1 BMP4 FGFR2
7 11.65 BGLAP GNAI3 PLCB4 RUNX2
8
Show member pathways
11.54 ACVR1 BMP2 BMP4 FGFR2 GNAI3 NOG
9
Show member pathways
11.53 BMP2 NOG RUNX2
10 11.48 ACVR1 BMP2 BMP4 NOG
11 11.4 BMP4 NOG RUNX2
12 11.28 BGLAP FGFR2 RUNX2
13 11.23 BGLAP RUNX2 TNFRSF11B
14 11.19 BGLAP IBSP RUNX2
15 11.03 GNAI3 PLCB4
16 10.97 BMP2 BMP4
17 10.91 BMP2 BMP4
18 10.85 BGLAP IBSP PLCB4 RUNX2
19 10.48 BGLAP IBSP TNFRSF11B

GO Terms for Ankylosis

Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 BGLAP BMP2 BMP4 FGFR2 IBSP NOG

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 in utero embryonic development GO:0001701 9.94 ACVR1 BMP2 FGFR2 NOG
2 cartilage development GO:0051216 9.86 BMP2 BMP4 NOG
3 cell fate commitment GO:0045165 9.84 BMP2 BMP4 FGFR2
4 positive regulation of epithelial cell proliferation GO:0050679 9.83 BMP4 FGFR2 NOG
5 odontogenesis of dentin-containing tooth GO:0042475 9.83 BMP2 BMP4 RUNX2
6 ossification GO:0001503 9.83 BGLAP BMP2 BMP4 RUNX2
7 bone development GO:0060348 9.82 BGLAP BMP4 FGFR2
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 ACVR1 BMP2 BMP4
9 positive regulation of osteoblast differentiation GO:0045669 9.8 ACVR1 BMP2 BMP4 RUNX2
10 ureteric bud development GO:0001657 9.79 BMP4 FGFR2 NOG
11 chondrocyte differentiation GO:0002062 9.78 BMP2 BMP4 RUNX2
12 cellular response to growth factor stimulus GO:0071363 9.78 BGLAP BMP2 BMP4 IBSP
13 epithelial to mesenchymal transition GO:0001837 9.77 BMP2 FGFR2 NOG
14 embryonic cranial skeleton morphogenesis GO:0048701 9.77 BMP4 FGFR2 RUNX2
15 odontogenesis GO:0042476 9.76 BGLAP BMP4 FGFR2
16 positive regulation of bone mineralization GO:0030501 9.75 ACVR1 BMP2 BMP4
17 endoderm development GO:0007492 9.74 BMP4 NOG
18 mesoderm formation GO:0001707 9.74 ACVR1 BMP4 NOG
19 pituitary gland development GO:0021983 9.73 BMP4 NOG
20 telencephalon development GO:0021537 9.73 BMP2 BMP4
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.73 BMP2 BMP4
22 endochondral ossification GO:0001958 9.73 BMP4 RUNX2
23 cardiac muscle cell differentiation GO:0055007 9.73 BMP2 BMP4
24 negative regulation of apoptotic signaling pathway GO:2001234 9.72 GNAI3 NOG
25 anatomical structure formation involved in morphogenesis GO:0048646 9.72 BMP4 NOG
26 regulation of bone mineralization GO:0030500 9.72 ANKH BGLAP
27 lung morphogenesis GO:0060425 9.72 BMP4 NOG
28 osteoblast development GO:0002076 9.71 BGLAP RUNX2
29 positive regulation of cartilage development GO:0061036 9.71 BMP2 BMP4
30 positive regulation of ossification GO:0045778 9.71 BMP2 BMP4
31 regulation of ossification GO:0030278 9.71 ACVR1 RUNX2
32 regulation of osteoblast differentiation GO:0045667 9.71 FGFR2 RUNX2
33 outflow tract septum morphogenesis GO:0003148 9.71 ACVR1 BMP4 FGFR2
34 bone mineralization GO:0030282 9.71 BGLAP BMP2 FGFR2 IBSP
35 smooth muscle cell differentiation GO:0051145 9.7 ACVR1 BMP4
36 mesodermal cell differentiation GO:0048333 9.7 BMP4 FGFR2
37 pathway-restricted SMAD protein phosphorylation GO:0060389 9.7 ACVR1 BMP2
38 response to inorganic substance GO:0010035 9.7 BGLAP TNFRSF11B
39 atrioventricular valve morphogenesis GO:0003181 9.69 ACVR1 BMP2
40 embryonic skeletal joint morphogenesis GO:0060272 9.69 BMP4 NOG
41 pharyngeal arch artery morphogenesis GO:0061626 9.69 BMP4 NOG
42 endocardial cushion morphogenesis GO:0003203 9.69 ACVR1 BMP2 NOG
43 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.68 BMP2 RUNX2
44 bud elongation involved in lung branching GO:0060449 9.68 BMP4 FGFR2
45 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.68 BMP4 FGFR2
46 regulation of fibroblast growth factor receptor signaling pathway GO:0040036 9.67 FGFR2 RUNX2
47 telencephalon regionalization GO:0021978 9.67 BMP2 BMP4
48 regulation of smooth muscle cell differentiation GO:0051150 9.66 BMP4 FGFR2
49 branching involved in prostate gland morphogenesis GO:0060442 9.65 BMP4 FGFR2
50 prostate gland morphogenesis GO:0060512 9.65 BMP4 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 co-receptor binding GO:0039706 8.96 BMP2 BMP4
2 BMP receptor binding GO:0070700 8.62 BMP2 BMP4

Sources for Ankylosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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