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MCID: ANK001
MIFTS: 51

Ankylosis

Categories: Bone diseases, Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Ankylosis

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MalaCards integrated aliases for Ankylosis:

Name: Ankylosis 12 74 15 71

Classifications:

MalaCards categories:
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:227
ICD9CM 34 718.5
SNOMED-CT 67 36504009
ICD10 32 M24.6
UMLS 71 C0003090
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Summaries for Ankylosis

About this section
Disease Ontology : 12 Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself.

MalaCards based summary : Ankylosis is related to proximal symphalangism and fibrodysplasia ossificans progressiva, and has symptoms including joint stiffness, arthralgia and metatarsalgia. An important gene associated with Ankylosis is ANKH (ANKH Inorganic Pyrophosphate Transport Regulator), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Celecoxib and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 Ankylosis is a stiffness of a joint due to abnormal adhesion and rigidity of the bones of the joint,... more...

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Related Diseases for Ankylosis

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Diseases related to Ankylosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 proximal symphalangism 32.7 NOG BMP4 BMP2 ACVR1
2 fibrodysplasia ossificans progressiva 32.7 NOG BMP4 BMP2 ACVR1
3 auriculocondylar syndrome 1 32.4 PLCB4 GNAI3
4 pfeiffer syndrome 32.3 SP7 RUNX2 NOG FGFR2 FGFR1 CCR6
5 spondyloarthropathy 1 32.3 TNFRSF11B MRAP CCR6 BGLAP ANKH
6 syngnathia 32.1 GNAI3 BMP4
7 hyperostosis 31.1 TNFRSF11B TGFB1 ANKH
8 myositis ossificans 30.9 SP7 BMP4 BGLAP ACVR1
9 chondrocalcinosis 30.6 TNFRSF11B ENPP1 ANKH
10 otosclerosis 30.6 TNFRSF11B TGFB1 NOG BMP4 BMP2
11 exostosis 30.6 MRAP BMP2 BGLAP
12 osteoarthritis 30.5 TNFRSF11B TGFB1 RUNX2 BMP2 BGLAP
13 dysostosis 30.5 RUNX2 NOG FGFR2 FGFR1
14 synostosis 30.5 RUNX2 NOG FGFR2 FGFR1 BMP4 BMP2
15 enthesopathy 30.4 MRAP ENPP1 CCR6
16 calcinosis 30.2 FGFR2 ENPP1 ANKH
17 craniometaphyseal dysplasia, autosomal dominant 30.1 SP7 RUNX2 IBSP ENPP1 BGLAP ANKH
18 chromosome 2q35 duplication syndrome 30.0 NOG FGFR2 FGFR1 BMP4 BMP2
19 hypophosphatemia 29.9 FGFR1 ENPP1 BGLAP
20 tooth agenesis 29.9 RUNX2 FGFR2 FGFR1 BMP4 BMP2
21 tooth resorption 29.9 TNFRSF11B RUNX2 IBSP BMP2 BGLAP
22 cleft palate, isolated 29.8 SP7 RUNX2 NOG FGFR2 FGFR1 BMP4
23 osteonecrosis 29.8 TNFRSF11B RUNX2 HIF1A BMP2 BGLAP
24 scoliosis 29.7 TNFRSF11B TGFB1 RUNX2 FGFR2 BMP4 BGLAP
25 bone resorption disease 29.7 TNFRSF11B SP7 RUNX2 IBSP CCR6 BMP2
26 osseous heteroplasia, progressive 29.4 RUNX2 NOG ENPP1 BMP4 BMP2 BGLAP
27 connective tissue disease 29.3 TNFRSF11B RUNX2 MRAP IBSP CCR6 BGLAP
28 osteoporosis 28.9 TNFRSF11B TGFB1 SP7 RUNX2 NOG IBSP
29 tooth ankylosis 12.8
30 stapes ankylosis with broad thumbs and toes 12.7
31 temporomandibular ankylosis 12.7
32 permanent molars, secondary retention of 12.6
33 craniostenosis, sagittal, with congenital heart disease, mental deficiency, and mandibular ankylosis 12.5
34 congenital temporomandibular joint ankylosis 12.3
35 glossopalatine ankylosis 12.3
36 glossopalatine ankylosis micrognathia ear anomalies 12.2
37 arthropathy 12.2
38 deafness, progressive, with stapes fixation 11.7
39 piussan lenaerts mathieu syndrome 11.5
40 symphalangism, proximal, 1a 11.5
41 multiple synostoses syndrome 11.5
42 hypoglossia-hypodactylia 11.5
43 restrictive dermopathy, lethal 11.3
44 auriculocondylar syndrome 2 11.3
45 pseudoarthrogryposis 11.2
46 distal arthrogryposis 11.2
47 symphalangism, distal 11.1
48 auriculocondylar syndrome 3 11.1
49 charlie m syndrome 11.1
50 inflammatory spondylopathy 10.7

Graphical network of the top 20 diseases related to Ankylosis:



Diseases related to Ankylosis
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Symptoms & Phenotypes for Ankylosis

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UMLS symptoms related to Ankylosis:


joint stiffness, arthralgia, metatarsalgia, joint symptom

MGI Mouse Phenotypes related to Ankylosis:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACVR1 ANKH BMP2 BMP4 CCR6 ENPP1
2 cellular MP:0005384 10.43 ACVR1 ANKH BGLAP BMP2 BMP4 ENPP1
3 craniofacial MP:0005382 10.42 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
4 homeostasis/metabolism MP:0005376 10.42 ACVR1 ANKH BGLAP BMP2 BMP4 CCR6
5 growth/size/body region MP:0005378 10.41 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
6 hematopoietic system MP:0005397 10.36 ANKH BGLAP BMP2 BMP4 CCR6 FGFR1
7 immune system MP:0005387 10.35 ACVR1 ANKH BGLAP BMP2 CCR6 ENPP1
8 mortality/aging MP:0010768 10.31 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
9 endocrine/exocrine gland MP:0005379 10.29 BGLAP BMP4 FGFR1 FGFR2 HIF1A MRAP
10 digestive/alimentary MP:0005381 10.27 ACVR1 BMP2 BMP4 FGFR1 FGFR2 HIF1A
11 limbs/digits/tail MP:0005371 10.27 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
12 hearing/vestibular/ear MP:0005377 10.22 ACVR1 ANKH BMP2 BMP4 ENPP1 FGFR1
13 embryo MP:0005380 10.21 ACVR1 BMP2 BMP4 FGFR1 FGFR2 HIF1A
14 nervous system MP:0003631 10.13 ACVR1 BMP2 BMP4 CCR6 ENPP1 FGFR1
15 muscle MP:0005369 10.11 ACVR1 ANKH BMP4 ENPP1 FGFR1 FGFR2
16 liver/biliary system MP:0005370 10.09 BMP4 ENPP1 FGFR2 HIF1A MRAP PLCB4
17 reproductive system MP:0005389 9.96 ANKH BGLAP BMP2 BMP4 FGFR1 FGFR2
18 skeleton MP:0005390 9.91 ACVR1 ANKH BGLAP BMP2 BMP4 ENPP1
19 respiratory system MP:0005388 9.81 ANKH BMP4 FGFR2 HIF1A MRAP NOG
20 vision/eye MP:0005391 9.32 BMP4 ENPP1 FGFR1 FGFR2 HIF1A NOG
Sources

Drugs & Therapeutics for Ankylosis

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Drugs for Ankylosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3 Analgesics, Non-Narcotic Phase 4
4 Analgesics Phase 4
5 Cyclooxygenase 2 Inhibitors Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Antirheumatic Agents Phase 4
10 Cholestyramine Resin Phase 4
11
Etanercept Approved, Investigational Phase 2, Phase 3 185243-69-0
12
Adalimumab Approved Phase 3 331731-18-1 16219006
13
tiludronate Approved, Investigational, Vet_approved Phase 3 89987-06-4 60937
14 Gastrointestinal Agents Phase 2, Phase 3
15 Immunologic Factors Phase 2, Phase 3
16 Immunosuppressive Agents Phase 2, Phase 3
17
Nitisinone Approved, Investigational Phase 2 104206-65-7 115355
18
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
19 Immunoglobulins Phase 1
20 Antibodies Phase 1
21 Antibodies, Monoclonal Phase 1
22
Infliximab Approved 170277-31-3
23 Dermatologic Agents
24 Tea

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Effects of Nonsteroidal Anti-inflammatory Drug (NSAID) on Inflammatory Lesion of Axial Spondyloarthritis Results From MRI Finding Completed NCT03190603 Phase 4 Celecoxib
2 Effects of NSAIDs on RAdiographic Damage in Ankylosing Spondylitis (ENRADAS) - a Prospective Randomised Controlled Trial Completed NCT00715091 Phase 4 diclophenac;diclophenac
3 Phase III Study of Human Bone Marrow-Derived Mesenchymal Stem Cells to Treat AS Unknown status NCT02809781 Phase 2, Phase 3 Etanercept
4 Review of Safety and Efficacy With Adalimumab in Patients With Active Ankylosing Spondylitis - An Open-Label Study to Evaluate the Response to Adalimumab in Patients Who Have Failed Standard Therapy or TNF-Alpha Inhibitors (RHAPSODY) Completed NCT00478660 Phase 3 adalimumab (Humira)
5 Mechanism of Action Study of Anti-IL17 Treatment in Spondyloarthritis: Impact on Cellular and Molecular Pathways of Synovial Inflammation and Tissue Remodeling Completed NCT03358134 Phase 3 Secukinumab
6 Therapeutic Efficacy of Tiludronic Acid on Inner Ear Involvement in Advanced Otosclerosis Terminated NCT01617057 Phase 3 tiludronic acid;Placebo
7 Arthrotomy With Irrigation and Debridement Versus Serial Arthrocentesis as Treatment for Septic Arthritis in Adults Withdrawn NCT00313365 Phase 3
8 Impact of Physical Therapy Program in Mouthbreathing Children After Adenotonsillectomy: Randomized Clinical Trial. Unknown status NCT02373553 Phase 1, Phase 2
9 Long-Term Clinical Trial of Nitisinone in Alkaptonuria Completed NCT00107783 Phase 2 Nitisinone (NTBC)
10 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
11 Periodontal Tissue Regeneration Using Autologous Periodontal Ligament Stem Cells: Randomized Controlled Clinical Trial Unknown status NCT01357785 Phase 1
12 An Ascending Single- and Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Gimsilumab in Healthy Subjects and Subjects With Ankylosing Spondylitis Completed NCT04205851 Phase 1 KIN-1901;Placebo
13 Performance of Pelvic Radiograph, CT -Scan and MRI of the Sacroiliac Joints to Diagnose Structural Sacroiliitis in a Large Cohort of Patients With Suspicion of Spondyloarthritis Unknown status NCT02888938
14 Selective Bilateral Laryngeal Reinnervation as a Secondary Treatment in Case of Bilateral Vocal Fold Paralysis: Analysis of Phonatory and Ventilatory Results Unknown status NCT02400008
15 Clinical and Radiological Outcomes of Centralization as a Surgical Management for Radial Club Hand Unknown status NCT03432052
16 An Open Label Extension, Investigator Initiated Trial to Examine Radiographic Progression , Efficacy and Safety of Long-Term Treatment With Infliximab in Patients With Ankylosing Spondylitis. EASIC (European Ankylosing Spondylitis Infliximab Cohort) Unknown status NCT00237419 infliximab
17 Transport Distraction Osteogenesis for Reconstruction of Ramus-Condyle Unit Following Release of Temporomandibular Joint Ankylosis Completed NCT04383964
18 CT Follow-Up of the SImmetry Sacroiliac Joint Fusion System Completed NCT02425631
19 Total Temporomandibular Joint Replacement System Post Approval Study Completed NCT00762944
20 FUNCTIONAL LIMITATIONS DUE TO the FOOT INVOLVEMENT IN SPONDYLOARTHRITIS Completed NCT01833468
21 The Effect Of Platelet Rich Fibrin on Implant Stability Completed NCT02190409
22 Effect Of Anti TNF Alpha Therapy On Disease Activity And Bone Health, And Their Adverse Effects In Ankylosing Spondylitis In A North Indian Population Completed NCT01361542 anti TNF alpha agent;Anti TNF alpha therapy
23 Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot Study Completed NCT02456272
24 Application of Virtual Mandibular Position in Temporomandibular Jont Reconstruction With Costochondral Graft in Children Jaw Deformity. Recruiting NCT03845088
25 Study of Validation of Measurements of the Movement of Stiff Treated Teeth and Orthodontic Corticotomy Recruiting NCT02337153
26 Post Market Clinical Follow-Up Study Protocol for PROCOTYL® C Acetabular Components Recruiting NCT03576573
27 Retrospective and Prospective Clinical Outcomes Study of the Zimmer® Nexelâ„¢ Total Elbow Recruiting NCT02469662
28 Actis Total Hip System 2 Year Follow-up Recruiting NCT02783274
29 International, Multicenter, Prospective Registry to Collect Data of Patients Treated With Alloplastic Total Temporomandibular Joint (TMJ) Replacements Recruiting NCT03991728
30 Studies on the Natural History and Pathogenesis of Spondyloarthritis Recruiting NCT01422694
31 Pre-surgical CT Scan Assessment of Femoral Head Bone Mineral Density Before Resection of Neurogenic Heterotopic Ossification (NHO) of the Hip Active, not recruiting NCT03914521
32 Post Market Clinical Follow-up Study Protocol for PROFEMUR® Xm Femoral Stems Active, not recruiting NCT02309593
33 Post Market Clinical Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts Active, not recruiting NCT02351414
34 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator Cemented Femoral Stems Active, not recruiting NCT02397746
35 Evolusion Study Using the Zyga SImmetry Sacroiliac Joint Fusion System Active, not recruiting NCT02074761
36 Contribution of EOS in the Structural Evaluation of Spondyloarthritis Active, not recruiting NCT03863756
37 Post Market Clinical Follow-up Study Protocol for PROFEMUR® Gladiator Plasma Femoral Stems and PROCOTYL® L Beaded Acetabular Components Enrolling by invitation NCT02823834
38 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® L Revision Femoral Stems Enrolling by invitation NCT02314702
39 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator HA Coated Modular Femoral Stems Enrolling by invitation NCT02314611
40 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® TL Modular Femoral Stems Enrolling by invitation NCT02239783
41 Post Market Clinical Follow-up Study Protocol for DYNASTY® BioFoam® Acetabular Components Enrolling by invitation NCT02149667
42 Post Market Clinical Follow-Up Study Protocol for CONSERVE® Press-Fit Femoral Components Enrolling by invitation NCT02285842
43 Post Market Clinical Follow-Up Study for PROFEMUR® Preserve Classic Femoral Stem Not yet recruiting NCT04147559
44 The Use of Proximal Carpal Row Versus Iliac Crest Bone Graft in Total Wrist Fusion - a Randomized Controlled Multicenter Trial Comparing Two Operative Techniques (PROOF II - Trial) Not yet recruiting NCT04403958
45 Fatigue and Skeletal Muscle Impact in Severe Axial Spondylarthritis Not yet recruiting NCT03940911
46 Comparative Study Between Internal and External Distraction Osteogenesis in Lower Face Asymmetry Not yet recruiting NCT03540329
47 SI Joint Fusion and Decortication Using the SImmetry System Terminated NCT02560714
48 Evaluation of Circulating Osteogenic Factors in Trauma Patients (BMP-9) Terminated NCT01433536
49 Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Am Femoral Components and PROCOTYL® O HA Coated Acetabular Components Withdrawn NCT02507258

Search NIH Clinical Center for Ankylosis

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Genetic Tests for Ankylosis

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Anatomical Context for Ankylosis

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MalaCards organs/tissues related to Ankylosis:

40
Bone, Spinal Cord, Skin, Brain, Bone Marrow, Skeletal Muscle, T Cells
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Publications for Ankylosis

About this section

Articles related to Ankylosis:

(show top 50) (show all 4534)
# Title Authors PMID Year
1
MRI of the sacroiliac joints: what is and what is not sacroiliitis? 61
32453038 2020
2
Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators. 61
32224162 2020
3
Ultrasonographic Involvement of the anterior chest wall in Spondyloarthritis: Factors associated with 5-years structural progression. A prospective study in 58 patients. 61
32147567 2020
4
nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish. 61
32527964 2020
5
Post-traumatic arthritis of the sacroiliac joints mimicking inflammatory sacroiliitis: analysis of consecutive computed tomography examinations. 61
32044095 2020
6
MRI of sacroiliac joints for the diagnosis of axial SpA: prevalence of inflammatory and structural lesions in nulliparous, early postpartum and late postpartum women. 61
32522743 2020
7
Consequences of spinal ankylosis on bone trabecular fragility assessed on CT scans in patients with ankylosing spondylitis. A retrospective study. 61
32534203 2020
8
Fibrodysplasia Ossificans Progressiva 61
32525643 2020
9
Costochondral graft in growing patients with hemifacial microsomia case series: Long term results compared with non treated patients. 61
32515152 2020
10
Evaluating upadacitinib for the treatment of rheumatoid arthritis. 61
32515665 2020
11
Identification of an unknown frameshift variant of NOG in a Han Chinese family with proximal symphalangism. 61
32478388 2020
12
Endoscopic Management of Malleus Head Fixation in Revision Stapes Surgery. 61
32080028 2020
13
Neurophysiological mechanisms of hypertonia and hypotonia in children with spastic cerebral palsy: surgical implications. 61
32548670 2020
14
Influence of anti-allergic drugs used systemically on the process of root resorption during delayed tooth replantation: A study in rats. 61
31845526 2020
15
The Nuances of Temporomandibular Joint Ankylosis Surgery: Tips and Tricks. 61
32346227 2020
16
Total Hip Arthroplasty for Ankylosis Requiring Rotational Rectus Femoris Flap and Skin Graft for Wound Closure. 61
32346585 2020
17
Computer-guided gap arthroplasty: a new approach to the execution of preplanned osteotomies for the treatment of bony ankylosis of the temporomandibular joint. 61
32534812 2020
18
Evaluation of Success of Transport Disc Distraction Osteogenesis and Costochondral Graft for Ramus Condyle Unit Reconstruction in Pediatric Temporomandibular Joint Ankylosis. 61
32105616 2020
19
Effect of Preoperative Intramuscular Injection of Botulinum Toxin A on Pain and Mouth Opening After Surgical Intervention in Temporomandibular Joint Ankylosis Cases: A Controlled Clinical Trial. 61
32171600 2020
20
Surgical correction of ankylosed TMJ in a child: case report. 61
32572708 2020
21
Application of Human Amniotic Membrane in Temporomandibular Joint Osteoarthritis. 61
32195845 2020
22
Scoring magnetic resonance imaging (MRI) inflammation and structural lesions in sacroiliac joints of patients with axial spondyloarthritis: assessment of all MRI slices of the cartilaginous compartment versus standardized six or five slices. 61
31847676 2020
23
Is dermis fat arthroplasty better than plain gap arthroplasty? A prospective randomised controlled trial. 61
32456996 2020
24
Bilateral temporomandibular joint reconstructions with stock alloplastic prostheses on a distracted mandible - A case report. 61
32407250 2020
25
Self-reported baseline phenotypes from the International Fibrodysplasia Ossificans Progressiva (FOP) Association Global Registry. 61
32062004 2020
26
Consequences of tooth luxation associated with complicated crown fracture: a case report. 61
32348245 2020
27
Negative Regulation of Osteoclast Commitment by Intracellular Protein Phosphatase Magnesium-Dependent 1A. 61
31762216 2020
28
Facet joint ankylosis in r-axSpA: detection and 2-year progression on whole spine low-dose CT and comparison with syndesmophyte progression. 61
32417911 2020
29
Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis. 61
32448352 2020
30
Strategy for the Treatment of Zygomatic-Coronoid Ankylosis. 61
31856134 2020
31
Patellofemoral ankylosis: case report and technical note. 61
32361953 2020
32
Orthodontic treatment recommendation and expected adverse reactions in patients with a history of dental trauma: A survey among general dentists, paediatric dentists, and orthodontic specialists. 61
31803975 2020
33
Intentional replantation of periodontally involved hopeless teeth: a case series study. 61
31410671 2020
34
Pediatric Mandibular Condylar Fractures With Concomitant Cervical Spine Injury: A Treatment Protocol for Prevention of Temporomandibular Joint Ankylosis. 61
32028362 2020
35
Evaluating the remodeling of condyles reconstructed by transport distraction osteogenesis in the treatment of temporomandibular joint ankylosis. 61
32209271 2020
36
Re: Protocol for the management of ankylosis of the temporomandibular joint. 61
32386945 2020
37
Evaluation of Mandibular Symmetry in Patients With Condylar Osteochondroma Who Underwent Intro-Oral Condylar Resection and Simultaneous Bimaxillary Orthognathic Surgery. 61
32310874 2020
38
Outcomes and Survivorship of Biomet Microfixation Total Joint Replacement System: Results From an FDA Postmarket Study. 61
32439381 2020
39
Surgical reconstruction of the foramen tympanicum: What is known and how we do it. 61
32360752 2020
40
3D Printed Patient-Specific Acetabular Jig for Cup Placement in Total Hip Arthroplasty. 61
32257035 2020
41
Radiographic scoring systems for psoriatic arthritis are insufficient for psoriatic arthritis mutilans: results from the Nordic PAM Study. 61
32426163 2020
42
Correction to: Reducing macrophage numbers alleviates temporomandibular joint ankylosis. 61
31736014 2020
43
Re: Protocol for the management of ankylosis of the temporomandibular joint. 61
32081444 2020
44
A new clinical classification and treatment strategies for temporomandibular joint ankylosis. 61
32247547 2020
45
Risk of ankylosis of 400 avulsed and replanted human teeth in relation to length of dry storage: A re-evaluation of a long-term clinical study. 61
31631495 2020
46
Early resection of ectopic bone in patients with heterotopic ossification about the hip after trauma. 61
32035630 2020
47
Treatment of avulsed immature permanent teeth in Beijing China: A retrospective comparison between 2008 and 2015. 61
32216025 2020
48
"Choledochoscope" as an Important Addition in Difficult Airway Management: A Case Report. 61
31876560 2020
49
Total hip arthroplasty by direct anterior approach in the lateral position for the treatment of ankylosed hips. 61
32185574 2020
50
Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children. 61
32209120 2020
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Variations for Ankylosis

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Expression for Ankylosis

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Search GEO for disease gene expression data for Ankylosis.
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Pathways for Ankylosis

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Pathways related to Ankylosis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.77 TGFB1 PLCB4 HIF1A GNAI3 FGFR2 FGFR1
2
PEDF Induced Signaling 63
Show member pathways
 13.61 TNFRSF11B TGFB1 PLCB4 GNAI3 FGFR2 FGFR1
3
Akt Signaling 63
Show member pathways
 13.31 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 CCR6
4
CREB Pathway 63
Show member pathways
 13.28 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
5
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.24 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
6
PAK Pathway 63
Show member pathways
 13.23 TGFB1 PLCB4 FGFR2 FGFR1 CCR6 BMP4
7
Phospholipase-C Pathway 63
Show member pathways
 12.99 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1 BMP4
8
p70S6K Signaling 63
Show member pathways
 12.96 TGFB1 HIF1A GNAI3 FGFR2 FGFR1 BMP4
9
NFAT and Cardiac Hypertrophy 63
Show member pathways
 12.81 TGFB1 PLCB4 GNAI3 FGFR2 FGFR1
10
NF-KappaB Family Pathway 63
Show member pathways
 12.66 TGFB1 FGFR2 FGFR1 BMP4 BMP2
11
Pathways in cancer 36
12.48 TGFB1 PLCB4 HIF1A GNAI3 FGFR2 FGFR1
12
Mesodermal Commitment Pathway 1
Show member pathways
 12.46 TGFB1 NOG FGFR1 BMP4 ACVR1
13
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.36 TGFB1 FGFR2 FGFR1 BMP4 BMP2
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.22 TGFB1 FGFR2 FGFR1 BMP4 BMP2
15
Signaling pathways regulating pluripotency of stem cells 36
12.07 FGFR2 FGFR1 BMP4 ACVR1
16
Adipogenesis 1
12.01 TGFB1 HIF1A BMP4 BMP2
17
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 11.94 TGFB1 NOG GNAI3 FGFR2 BMP4 BMP2
18
Angiogenesis (CST) 4
11.77 TGFB1 HIF1A FGFR2 FGFR1
19
Neural Stem Cells and Lineage-specific Markers 64
11.74 FGFR1 BMP4 BMP2
20
Parathyroid hormone synthesis, secretion and action 36
11.74 RUNX2 PLCB4 GNAI3 FGFR1 BGLAP
21
Elastic fibre formation 65
Show member pathways
 11.7 TGFB1 BMP4 BMP2
22
Signaling by BMP 65
Show member pathways
 11.69 RUNX2 NOG BMP2
23
G-protein signaling_RhoA regulation pathway 22
11.69 TGFB1 FGFR2 FGFR1 BMP4 BMP2
24
Central carbon metabolism in cancer 36
11.68 HIF1A FGFR2 FGFR1
25
TGF-beta signaling pathway (KEGG) 36
11.63 TGFB1 NOG BMP4 BMP2 ACVR1
26
Endochondral Ossification 1
11.61 TGFB1 RUNX2 FGFR1 ENPP1
27
Cardiac Progenitor Differentiation 1
11.54 TGFB1 NOG BMP4
28
TGF-beta Receptor Signaling (WikiPathways) 1
11.52 TGFB1 RUNX2 NOG BMP4
29
Notch-mediated HES/HEY network 1
11.49 RUNX2 HIF1A BGLAP
30
Differentiation Pathway 1
11.49 TGFB1 NOG BMP4
31
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.45 TNFRSF11B RUNX2 BGLAP
32
FGF signaling pathway 1
11.41 RUNX2 FGFR2 FGFR1 BGLAP
33
Interleukin-11 Signaling Pathway 1
11.35 TGFB1 RUNX2 IBSP BGLAP
34
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.26 RUNX2 PLCB4 IBSP BGLAP
35
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.15 TGFB1 SP7 RUNX2 NOG BMP4 BMP2
36
G-protein signaling_Rap2B regulation pathway 22
10.96 TGFB1 GNAI3 FGFR2 FGFR1 BMP4 BMP2
37
Osteoblast Signaling 1
10.8 TNFRSF11B IBSP BGLAP
Sources

GO Terms for Ankylosis

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Cellular components related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 SLC20A2 FGFR2 FGFR1 ENPP1 CCR6 ANKH
2 extracellular space GO:0005615 9.76 TNFRSF11B TGFB1 NOG IBSP ENPP1 BMP4
3 extracellular region GO:0005576 9.65 TNFRSF11B TGFB1 NOG IBSP FGFR2 FGFR1
4 BMP receptor complex GO:0070724 8.62 BMP2 ACVR1

Biological processes related to Ankylosis according to GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.24 TGFB1 SP7 RUNX2 NOG HIF1A FGFR2
2 negative regulation of transcription by RNA polymerase II GO:0000122 10.23 TGFB1 NOG FGFR2 FGFR1 BMP4 BMP2
3 positive regulation of transcription, DNA-templated GO:0045893 10.18 TGFB1 RUNX2 HIF1A BMP4 BMP2 ACVR1
4 positive regulation of cell proliferation GO:0008284 10.16 TGFB1 RUNX2 FGFR2 FGFR1 BMP4
5 positive regulation of gene expression GO:0010628 10.13 TGFB1 RUNX2 NOG HIF1A BMP4 BMP2
6 regulation of gene expression GO:0010468 10.1 TGFB1 RUNX2 HIF1A FGFR1 BMP4
7 positive regulation of cell migration GO:0030335 10.06 TGFB1 BMP4 BMP2 ACVR1
8 heart development GO:0007507 10.06 TGFB1 BMP4 BMP2 ACVR1
9 negative regulation of gene expression GO:0010629 10.05 TGFB1 NOG HIF1A FGFR1 BMP4 BMP2
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.04 TGFB1 FGFR2 BMP4 BMP2
11 angiogenesis GO:0001525 10.04 HIF1A FGFR2 FGFR1 BMP4 ACVR1
12 in utero embryonic development GO:0001701 10.02 NOG FGFR2 FGFR1 BMP2 ACVR1
13 positive regulation of neuron differentiation GO:0045666 9.95 FGFR1 BMP4 BMP2
14 lung development GO:0030324 9.94 FGFR2 FGFR1 BMP4
15 wound healing GO:0042060 9.94 TGFB1 NOG FGFR2
16 neural tube closure GO:0001843 9.94 TGFB1 NOG BMP4
17 positive regulation of endothelial cell proliferation GO:0001938 9.92 HIF1A BMP4 BMP2
18 cell fate commitment GO:0045165 9.92 FGFR2 BMP4 BMP2
19 cartilage development GO:0051216 9.92 NOG HIF1A BMP4 BMP2
20 negative regulation of epithelial cell proliferation GO:0050680 9.91 TGFB1 FGFR2 BMP4
21 bone development GO:0060348 9.91 FGFR2 BMP4 BGLAP
22 SMAD protein signal transduction GO:0060395 9.91 TGFB1 BMP4 BMP2
23 positive regulation of epithelial cell proliferation GO:0050679 9.91 TGFB1 NOG FGFR2 BMP4
24 odontogenesis of dentin-containing tooth GO:0042475 9.9 RUNX2 BMP4 BMP2
25 outflow tract morphogenesis GO:0003151 9.9 NOG HIF1A BMP4
26 positive regulation of blood vessel endothelial cell migration GO:0043536 9.9 TGFB1 HIF1A FGFR1
27 positive regulation of osteoblast differentiation GO:0045669 9.9 RUNX2 BMP4 BMP2 ACVR1
28 ossification GO:0001503 9.89 RUNX2 IBSP BMP4 BMP2 BGLAP
29 positive regulation of cell differentiation GO:0045597 9.88 FGFR1 BMP4 BMP2
30 negative regulation of cell cycle GO:0045786 9.88 TGFB1 BMP4 BMP2
31 regulation of cell differentiation GO:0045595 9.88 RUNX2 FGFR1 BMP4
32 skeletal system morphogenesis GO:0048705 9.87 RUNX2 FGFR2 FGFR1
33 positive regulation of epithelial to mesenchymal transition GO:0010718 9.87 TGFB1 BMP4 BMP2
34 odontogenesis GO:0042476 9.86 FGFR2 BMP4 BGLAP
35 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.86 TGFB1 BMP4 BMP2 ACVR1
36 mesoderm formation GO:0001707 9.85 NOG BMP4 ACVR1
37 biomineral tissue development GO:0031214 9.85 IBSP ENPP1 BGLAP
38 bone mineralization GO:0030282 9.85 IBSP FGFR2 BMP2 BGLAP
39 chondrocyte differentiation GO:0002062 9.85 TGFB1 RUNX2 FGFR1 BMP4 BMP2
40 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.84 TGFB1 HIF1A BMP4 BMP2
41 embryonic cranial skeleton morphogenesis GO:0048701 9.83 RUNX2 FGFR2 BMP4
42 endoderm development GO:0007492 9.83 TGFB1 NOG BMP4
43 positive regulation of bone mineralization GO:0030501 9.83 TGFB1 BMP4 BMP2 ACVR1
44 ureteric bud development GO:0001657 9.83 TGFB1 NOG FGFR2 FGFR1 BMP4
45 outflow tract septum morphogenesis GO:0003148 9.82 FGFR2 BMP4 ACVR1
46 regulation of bone mineralization GO:0030500 9.8 ENPP1 BGLAP ANKH
47 BMP signaling pathway GO:0030509 9.8 TGFB1 RUNX2 NOG BMP4 BMP2 ACVR1
48 endocardial cushion morphogenesis GO:0003203 9.79 NOG BMP2 ACVR1
49 positive regulation of SMAD protein signal transduction GO:0060391 9.77 TGFB1 BMP4
50 regulation of osteoblast differentiation GO:0045667 9.77 RUNX2 FGFR2

Molecular functions related to Ankylosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 TNFRSF11B TGFB1 BMP4 BMP2
2 BMP receptor binding GO:0070700 9.32 BMP4 BMP2
3 co-receptor binding GO:0039706 9.26 BMP4 BMP2
4 inorganic phosphate transmembrane transporter activity GO:0005315 8.96 SLC20A2 ANKH
5 fibroblast growth factor-activated receptor activity GO:0005007 8.62 FGFR2 FGFR1
Sources

Sources for Ankylosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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