Aliases & Classifications for Annular Erythema

MalaCards integrated aliases for Annular Erythema:

Name: Annular Erythema 58 56 74

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
annular erythema:
Inheritance autosomal dominant inheritance


Summaries for Annular Erythema

MalaCards based summary : Annular Erythema is related to keratolytic winter erythema and sjogren syndrome. An important gene associated with Annular Erythema is CTSB (Cathepsin B), and among its related pathways/superpathways are Allograft rejection and Immune response CCR3 signaling in eosinophils. Affiliated tissues include t cells, breast and skin, and related phenotypes are erythema and cellular

Description from OMIM: 106500

Related Diseases for Annular Erythema

Graphical network of the top 20 diseases related to Annular Erythema:



Diseases related to Annular Erythema

Symptoms & Phenotypes for Annular Erythema

Human phenotypes related to Annular Erythema:

33
# Description HPO Frequency HPO Source Accession
1 erythema 33 HP:0010783

Symptoms via clinical synopsis from OMIM:

58
Skin:
annular erythema

Clinical features from OMIM:

106500

MGI Mouse Phenotypes related to Annular Erythema:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.46 CTSB HSPG2 ICAM1 ITGB2
2 immune system MP:0005387 9.26 CTSB HSPG2 ICAM1 ITGB2
3 integument MP:0010771 8.92 CTSB HSPG2 ICAM1 ITGB2

Drugs & Therapeutics for Annular Erythema

Search Clinical Trials , NIH Clinical Center for Annular Erythema

Genetic Tests for Annular Erythema

Anatomical Context for Annular Erythema

MalaCards organs/tissues related to Annular Erythema:

42
T Cells, Breast, Skin, Colon, Prostate, Thyroid, Neutrophil

Publications for Annular Erythema

Articles related to Annular Erythema:

(show top 50) (show all 112)
# Title Authors Year
1
Neonate with annular erythema on his face and scalp at birth. ( 31017361 )
2019
2
Neonate with annular erythema on his face and scalp at birth. ( 31017364 )
2019
3
Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. ( 30186440 )
2018
4
Two cases of annular erythema without bullous lesions by autoimmune blistering diseases. ( 26382039 )
2018
5
Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome. ( 28771678 )
2018
6
Exertional myalgia, contractures and annular erythema in a patient with muscle lactate dehydrogenase (LDH) deficiency. ( 29198466 )
2018
7
Dapsone for Recalcitrant Eosinophilic Annular Erythema: A Case Report and Literature Review. ( 29222624 )
2018
8
Atypical presentation of eosinophilic annular erythema in a 5-year-old girl. ( 29341284 )
2018
9
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. ( 29387758 )
2018
10
Annular erythema nodosum leprosum reaction in a young male: a rare presentation. ( 29392708 )
2018
11
Efficacy of suplatast tosilate in a case of recurrent eosinophilic annular erythema. ( 29655235 )
2018
12
Eosinophilic annular erythema treated with dupilumab. ( 29790187 )
2018
13
Image Gallery: Annular erythema related to Capnocytophaga canimorsus bacteraemia after a dog bite. ( 30387520 )
2018
14
Eosinophilic annular erythema: A late but complete response to hydroxychloroquine. ( 26768795 )
2017
15
Bullous eosinophilic annular erythema. ( 27511273 )
2017
16
Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases. ( 28543605 )
2017
17
Eosinophilic annular erythema localized on the neck. ( 29165308 )
2017
18
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. ( 29200781 )
2017
19
Eosinophilic annular erythema in adults: report of two cases and review of the literature. ( 29267450 )
2017
20
Eosinophilic annular erythema limited on the palms and the soles and possibly associated with thymoma. ( 25816730 )
2016
21
Anti-signal recognition particle antibody-positive polymyositis in a patient with Sjögren's syndrome showing various types of annular erythema: Positive correlation between the activities of annular erythema and myositis. ( 26972113 )
2016
22
Eosinophilic annular erythema in a patient with autoimmune pancreatitis: Nicotinamide therapy may be beneficial for achieving remission. ( 27129768 )
2016
23
Eosinophilic annular erythema in childhood - Case report. ( 27579748 )
2016
24
Eosinophilic Annular Erythema Localized to the Palms and the Soles. ( 27904280 )
2016
25
Eosinophilic annular erythema in a patient with metastatic prostate adenocarcinoma. ( 25515818 )
2015
26
Eosinophilic annular erythema: complete clinical response with dapsone. ( 25556880 )
2015
27
Pyoderma gangrenosum and annular erythema associated with Sjögren's syndrome controlled with minocycline. ( 25899670 )
2015
28
Eosinophilic annular erythema: successful response to ultraviolet B therapy. ( 25958878 )
2015
29
Annular erythema and papules in infantile atopic dermatitis. ( 24202180 )
2014
30
Annular erythema associated with Sjögren's syndrome preceding overlap syndrome of rheumatoid arthritis and polymyositis with anti-PL-12 autoantibodies. ( 24322624 )
2014
31
Annular erythema in primary Sjogren's syndrome: description of 43 non-Asian cases. ( 24326481 )
2014
32
Annular erythema of Sjögren's syndrome treated successfully with low-dose cyclosporine. ( 24801928 )
2014
33
Immunohistochemical Analysis of Interleukin-17 Producing T Helper Cells and Regulatory T Cells Infiltration in Annular Erythema Associated with Sjögren's Syndrome. ( 24882975 )
2014
34
Eosinophilic annular erythema: attention must be paid. ( 25823085 )
2014
35
Eosinophilic annular erythema is a peculiar subtype in the spectrum of Wells syndrome: a multicentre long-term follow-up study. ( 22731886 )
2013
36
Bullous annular erythema as a cutaneous sign of vaginal stump adenocarcinoma. ( 23463841 )
2013
37
Annular erythema and photosensitivity as manifestations of efavirenz-induced cutaneous reactions: a review of five consecutive cases. ( 23852540 )
2013
38
A new type of annular erythema with perieccrine inflammation: erythema papulatum centrifugum. ( 23948702 )
2013
39
Systemic allergic contact dermatitis to palladium inlay manifesting as annular erythema. ( 22759481 )
2012
40
Eosinophilic annular erythema. ( 22483519 )
2012
41
Spontaneously resolving eosinophilic annular erythema. ( 22794821 )
2012
42
Familial annular erythema--a rare dermatology diagnosis. ( 21276056 )
2011
43
Recurrent annular erythema after thymectomy. ( 21527370 )
2011
44
Eosinophilic annular erythema: an expression of the clinical and pathological polymorphism of Wells syndrome. ( 21920240 )
2011
45
Annular erythema associated with Sjögren's syndrome: review of the literature on the management and clinical analysis of skin lesions. ( 20054701 )
2010
46
Annular erythema as a sign of recurrent breast cancer. ( 20546222 )
2010
47
Is annular erythema developing in a pregnant patient with Sjögren's syndrome a predictor of potential neonatal lupus erythematosus in the infant? ( 21039792 )
2010
48
Eosinophilic annular erythema responsive to chloroquin. ( 19171544 )
2009
49
Mycosis fungoides mimicking an annular erythema. ( 19486059 )
2009
50
Annular erythema associated with anti-Ro/SS-A and anti-La/SS-B antibodies: a new case in a Hispanic patient. ( 19999246 )
2009

Variations for Annular Erythema

Expression for Annular Erythema

Search GEO for disease gene expression data for Annular Erythema.

Pathways for Annular Erythema

Pathways related to Annular Erythema according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 CTSB ICAM1 ITGB2
2
Show member pathways
11.89 ICAM1 ITGB2
3
Show member pathways
11.71 HSPG2 ICAM1 ITGB2
4 11.7 ICAM1 ITGB2
5 11.65 ICAM1 ITGB2
6 11.6 ICAM1 ITGB2
7
Show member pathways
11.58 CTSB HSPG2 ICAM1 ITGB2
8 11.55 ICAM1 ITGB2
9
Show member pathways
11.52 HSPG2 ICAM1 ITGB2
10 11.44 ICAM1 ITGB2
11 11.24 ICAM1 ITGB2
12
Show member pathways
11.23 CTSB HSPG2 ITGB2
13 11.06 ICAM1 ITGB2
14 11 ICAM1 ITGB2
15 10.9 ICAM1 ITGB2

GO Terms for Annular Erythema

Cellular components related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.46 CTSB HSPG2 ICAM1 ITGB2
2 membrane raft GO:0045121 9.26 ICAM1 ITGB2
3 focal adhesion GO:0005925 9.13 HSPG2 ICAM1 ITGB2
4 collagen-containing extracellular matrix GO:0062023 8.8 CTSB HSPG2 ICAM1

Biological processes related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.48 ICAM1 ITGB2
2 leukocyte migration GO:0050900 9.46 ICAM1 ITGB2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 ICAM1 ITGB2
4 regulation of cell shape GO:0008360 9.4 ICAM1 ITGB2
5 cell-cell adhesion GO:0098609 9.37 ICAM1 ITGB2
6 viral entry into host cell GO:0046718 9.32 CTSB ICAM1
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 ICAM1 ITGB2
8 leukocyte cell-cell adhesion GO:0007159 9.16 ICAM1 ITGB2
9 cell adhesion mediated by integrin GO:0033627 8.96 ICAM1 ITGB2
10 extracellular matrix organization GO:0030198 8.8 HSPG2 ICAM1 ITGB2

Molecular functions related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.96 ICAM1 ITGB2
2 integrin binding GO:0005178 8.62 ICAM1 ITGB2

Sources for Annular Erythema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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