Aliases & Classifications for Annular Erythema

MalaCards integrated aliases for Annular Erythema:

Name: Annular Erythema 57 54 70

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
annular erythema:
Inheritance autosomal dominant inheritance


External Ids:

OMIM® 57 106500
MedGen 41 C0234906
UMLS 70 C0234906

Summaries for Annular Erythema

MalaCards based summary : Annular Erythema is related to vasculitis and rheumatoid arthritis. An important gene associated with Annular Erythema is CTSB (Cathepsin B), and among its related pathways/superpathways are Allograft rejection and Immune response CCR3 signaling in eosinophils. Affiliated tissues include skin, breast and t cells, and related phenotypes are erythema and integument

More information from OMIM: 106500

Related Diseases for Annular Erythema

Diseases related to Annular Erythema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.5 ITGB2 ICAM1
2 rheumatoid arthritis 28.8 ITGB2 ICAM1 CTSB
3 keratolytic winter erythema 11.2
4 cutaneous lupus erythematosus 10.4
5 subacute cutaneous lupus erythematosus 10.4
6 hypereosinophilic syndrome 10.4
7 lupus erythematosus 10.3
8 sjogren syndrome 10.3
9 wells syndrome 10.3
10 exanthem 10.2
11 autoimmune disease 10.2
12 systemic lupus erythematosus 10.2
13 mycosis fungoides 10.2
14 polymyositis 10.1
15 lyme disease 10.1
16 keratoconjunctivitis sicca 10.1
17 enthesopathy 10.1
18 dermatitis 10.1
19 myositis 10.0
20 dowling-degos disease 1 10.0
21 rheumatic fever-related antigen 10.0
22 dermatitis, atopic 10.0
23 erythema nodosum 10.0
24 angioimmunoblastic t-cell lymphoma 10.0
25 sleeping sickness 10.0
26 trypanosomiasis 10.0
27 xerophthalmia 10.0
28 rheumatic fever 10.0
29 autoimmune hepatitis 10.0
30 adenocarcinoma 10.0
31 cellulitis 10.0
32 skin disease 10.0
33 pyoderma 10.0
34 pyoderma gangrenosum 10.0
35 ulcerative colitis 10.0
36 gingival overgrowth 9.9 HSPG2 CTSB
37 breast cancer 9.9
38 hashimoto thyroiditis 9.9
39 scleroderma, familial progressive 9.9
40 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
41 thymoma, familial 9.9
42 suppression of tumorigenicity 12 9.9
43 dermatitis herpetiformis, familial 9.9
44 systemic lupus erythematosus 1 9.9
45 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
46 myelodysplastic syndrome 9.9
47 peripheral vascular disease 9.9
48 autoimmune pancreatitis 9.9
49 hemophagocytic lymphohistiocytosis 9.9
50 erythema multiforme 9.9

Graphical network of the top 20 diseases related to Annular Erythema:



Diseases related to Annular Erythema

Symptoms & Phenotypes for Annular Erythema

Human phenotypes related to Annular Erythema:

31
# Description HPO Frequency HPO Source Accession
1 erythema 31 HP:0010783

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skin:
annular erythema

Clinical features from OMIM®:

106500 (Updated 20-May-2021)

MGI Mouse Phenotypes related to Annular Erythema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 CTSB HSPG2 ICAM1 ITGB2

Drugs & Therapeutics for Annular Erythema

Search Clinical Trials , NIH Clinical Center for Annular Erythema

Genetic Tests for Annular Erythema

Anatomical Context for Annular Erythema

MalaCards organs/tissues related to Annular Erythema:

40
Skin, Breast, T Cells, Thyroid, Prostate

Publications for Annular Erythema

Articles related to Annular Erythema:

(show top 50) (show all 241)
# Title Authors PMID Year
1
Familial annular erythema. An apparently new dominant mutation. 61 57
5908098 1966
2
Analysis of T cell receptor Vbeta repertoires of annular erythema associated with Sjögren's syndrome. 61 54
9649694 1998
3
Spongiotic annular erythema in SS-A/SS-B antibody negative Sjögren's syndrome. 54 61
9563275 1998
4
[Recurrent annular erythema--cutaneous manifestation of Sjögren syndrome with anti SS-A (Ro) and anti SS-B (La) antibodies]. 54 61
8531373 1995
5
Lymphocyte response to staphylococcal enterotoxin B in patients with annular erythema associated with Sjögren syndrome. 54 61
2071745 1991
6
[Eosinophilic annular erythema in a 20-month-old girl]. 61
32930857 2021
7
Vitiligo masquerading as annular erythema in a young woman with low-grade skin phototype. 61
33660276 2021
8
A sinister rash in a lady with breast malignancy. 61
33742647 2021
9
sQUIZ your knowledge: Pruritic annular erythema on skin folds. 61
33772520 2021
10
Dupilumab use in dermatologic conditions beyond atopic dermatitis - a systematic review. 61
31693426 2021
11
[Purpura annularis telangiectodes : Case report and review of the literature]. 61
32803361 2021
12
Neonatal lupus erythematosus exacerbated by vaccination. 61
32881039 2020
13
Eosinophilic annular erythema: Report of four cases. 61
33025705 2020
14
Two Cases of Wells Syndrome with Marked Swelling in the Hands. 61
33344351 2020
15
Eosinophilic annular erythema in adults: a new case of this rare entity. 61
33460086 2020
16
Annular erythema as a cutaneous sign of recurrent ductal breast carcinoma, misdiagnosed as erythema chronicum migrans. 61
33054939 2020
17
Refractory eosinophilic annular erythema treated successfully with dupilumab. 61
32909389 2020
18
sQuiz your knowledge: a recurrent annular erythema. 61
32969818 2020
19
Mepolizumab Therapy for Recalcitrant Eosinophilic Annular Erythema in an Adult: A Case Report and Review of Treatment Options. 61
32578132 2020
20
Can artificial intelligence replace manual search for systematic literature? Review on cutaneous manifestations in primary Sjögren's syndrome. 61
31504928 2020
21
Overview on the treatment of Lyme disease in pregnancy. 61
31210468 2020
22
Erythema papulatum centrifugum and new diagnostic criteria. 61
31691949 2020
23
Relapsing annular erythema. 61
31997453 2020
24
Neonate with annular erythema on his face and scalp at birth. 61
31017364 2019
25
Neonate with annular erythema on his face and scalp at birth. 61
31017361 2019
26
Symmetric acral annular erythema: a variant of erythema annulare centrifugum, necrolytic acral erythema or a distinct clinical entity? 61
31320861 2019
27
Neutrophilic figurate erythema of infancy: A diagnostic challenge. 61
30430608 2019
28
Image Gallery: Annular erythema related to Capnocytophaga canimorsus bacteraemia after a dog bite. 61
30387520 2018
29
Dry skin manifestations in Sjögren syndrome and atopic dermatitis related to aberrant sudomotor function in inflammatory allergic skin diseases. 61
30104151 2018
30
Prolonged Treatment of Eosinophilic Erythema Annulare with Chloroquine. 61
30390730 2018
31
Efficacy of suplatast tosilate in a case of recurrent eosinophilic annular erythema. 61
29655235 2018
32
Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. 61
30186440 2018
33
Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome. 61
28771678 2018
34
Eosinophilic annular erythema treated with dupilumab. 61
29790187 2018
35
Atypical presentation of eosinophilic annular erythema in a 5-year-old girl. 61
29341284 2018
36
Annular erythema nodosum leprosum reaction in a young male: a rare presentation. 61
29392708 2018
37
Dapsone for Recalcitrant Eosinophilic Annular Erythema: A Case Report and Literature Review. 61
29222624 2018
38
Exertional myalgia, contractures and annular erythema in a patient with muscle lactate dehydrogenase (LDH) deficiency. 61
29198466 2018
39
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. 61
29387758 2018
40
Two cases of annular erythema without bullous lesions by autoimmune blistering diseases. 61
26382039 2018
41
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. 61
29200781 2017
42
Eosinophilic annular erythema localized on the neck. 61
29165308 2017
43
Cutaneous and Mucosal Manifestations of Sjögren's Syndrome. 61
28871434 2017
44
Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases. 61
28543605 2017
45
Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects. 61
29344321 2017
46
Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum. 61
29252183 2017
47
Eritema anular eosinofílico en un adulto Eosinophilic anular erythema in an adult. 61
29469795 2017
48
Eosinophilic annular erythema: A late but complete response to hydroxychloroquine. 61
26768795 2017
49
Urticaria vasculitis in a child: a case report and literature review. 61
28781836 2017
50
Neutrophilic Figurate Erythema. 61
28426486 2017

Variations for Annular Erythema

Expression for Annular Erythema

Search GEO for disease gene expression data for Annular Erythema.

Pathways for Annular Erythema

Pathways related to Annular Erythema according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 ITGB2 ICAM1 CTSB
2
Show member pathways
11.9 ITGB2 ICAM1
3 11.89 ITGB2 ICAM1
4 11.71 ITGB2 ICAM1
5
Show member pathways
11.68 ITGB2 HSPG2
6 11.64 ITGB2 ICAM1
7 11.58 ITGB2 ICAM1
8
Show member pathways
11.58 ITGB2 ICAM1 HSPG2 CTSB
9 11.53 ITGB2 ICAM1
10 11.44 ITGB2 ICAM1
11 11.4 ITGB2 ICAM1
12
Show member pathways
11.32 ITGB2 ICAM1 HSPG2
13 11.22 ITGB2 ICAM1
14 11.02 ITGB2 ICAM1
15 10.94 ITGB2 ICAM1
16 10.8 ITGB2 ICAM1

GO Terms for Annular Erythema

Cellular components related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.56 ITGB2 ICAM1 HSPG2 CTSB
2 focal adhesion GO:0005925 9.33 ITGB2 ICAM1 HSPG2
3 external side of plasma membrane GO:0009897 9.13 ITGB2 ICAM1 CTSB
4 collagen-containing extracellular matrix GO:0062023 8.8 ICAM1 HSPG2 CTSB

Biological processes related to Annular Erythema according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.51 ITGB2 ICAM1
2 leukocyte migration GO:0050900 9.49 ITGB2 ICAM1
3 cell-cell adhesion GO:0098609 9.48 ITGB2 ICAM1
4 receptor-mediated endocytosis GO:0006898 9.46 ITGB2 HSPG2
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 ITGB2 ICAM1
6 regulation of cell shape GO:0008360 9.4 ITGB2 ICAM1
7 viral entry into host cell GO:0046718 9.37 ICAM1 CTSB
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 ITGB2 ICAM1
9 leukocyte cell-cell adhesion GO:0007159 9.26 ITGB2 ICAM1
10 cell adhesion mediated by integrin GO:0033627 9.16 ITGB2 ICAM1
11 extracellular matrix organization GO:0030198 9.13 ITGB2 ICAM1 HSPG2
12 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 8.62 ITGB2 ICAM1

Molecular functions related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.16 ITGB2 ICAM1
2 integrin binding GO:0005178 8.96 ITGB2 ICAM1
3 amyloid-beta binding GO:0001540 8.62 ITGB2 HSPG2

Sources for Annular Erythema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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