Aliases & Classifications for Annular Erythema

MalaCards integrated aliases for Annular Erythema:

Name: Annular Erythema 57 55 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
annular erythema:
Inheritance autosomal dominant inheritance


Summaries for Annular Erythema

MalaCards based summary : Annular Erythema is related to polymyositis and wells syndrome. An important gene associated with Annular Erythema is HSPG2 (Heparan Sulfate Proteoglycan 2), and among its related pathways/superpathways are Integrin Pathway and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. Affiliated tissues include t cells, prostate and skin, and related phenotypes are erythema and integument

Description from OMIM: 106500

Related Diseases for Annular Erythema

Diseases related to Annular Erythema via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 polymyositis 10.0
2 wells syndrome 10.0
3 myositis 9.9
4 cutaneous lupus erythematosus 9.9
5 dermatitis 9.9
6 lupus erythematosus 9.9
7 subacute cutaneous lupus erythematosus 9.9
8 rheumatoid arthritis 9.7
9 mycosis fungoides 9.7
10 sjogren syndrome 9.7
11 suppression of tumorigenicity 12 9.7
12 dermatitis, atopic 9.7
13 arthritis 9.7
14 autoimmune hepatitis 9.7
15 hepatitis 9.7
16 prostatitis 9.7
17 hidradenitis 9.7
18 contact dermatitis 9.7
19 adenocarcinoma 9.7
20 allergic contact dermatitis 9.7
21 churg-strauss syndrome 9.7
22 thymoma 9.7
23 purpura 9.7
24 pyoderma 9.7
25 pancreatitis 9.7
26 pyoderma gangrenosum 9.7
27 vasculitis 9.7
28 genital herpes 9.7
29 allergic angiitis 9.7
30 autoimmune pancreatitis 9.7
31 mooren's ulcer 9.2 ICAM1 ITGB2
32 neutrophil migration 9.1 ICAM1 ITGB2
33 myocarditis 8.9 ICAM1 ITGB2

Graphical network of the top 20 diseases related to Annular Erythema:



Diseases related to Annular Erythema

Symptoms & Phenotypes for Annular Erythema

Symptoms via clinical synopsis from OMIM:

57
Skin:
annular erythema


Clinical features from OMIM:

106500

Human phenotypes related to Annular Erythema:

32
# Description HPO Frequency HPO Source Accession
1 erythema 32 HP:0010783

MGI Mouse Phenotypes related to Annular Erythema:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.13 HSPG2 ICAM1 ITGB2
2 vision/eye MP:0005391 8.8 HSPG2 ICAM1 ITGB2

Drugs & Therapeutics for Annular Erythema

Search Clinical Trials , NIH Clinical Center for Annular Erythema

Genetic Tests for Annular Erythema

Anatomical Context for Annular Erythema

MalaCards organs/tissues related to Annular Erythema:

41
T Cells, Prostate, Skin

Publications for Annular Erythema

Articles related to Annular Erythema:

(show all 46)
# Title Authors Year
1
Two cases of annular erythema without bullous lesions by autoimmune blistering diseases. ( 26382039 )
2018
2
Annular erythema nodosum leprosum reaction in a young male: a rare presentation. ( 29392708 )
2018
3
Exertional myalgia, contractures and annular erythema in a patient with muscle lactate dehydrogenase (LDH) deficiency. ( 29198466 )
2018
4
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. ( 29387758 )
2018
5
Atypical presentation of eosinophilic annular erythema in a 5-year-old girl. ( 29341284 )
2018
6
Efficacy of suplatast tosilate in a case of recurrent eosinophilic annular erythema. ( 29655235 )
2018
7
Eosinophilic annular erythema treated with dupilumab. ( 29790187 )
2018
8
Eosinophilic annular erythema: A late but complete response to hydroxychloroquine. ( 26768795 )
2017
9
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. ( 29200781 )
2017
10
Bullous eosinophilic annular erythema. ( 27511273 )
2017
11
Eosinophilic annular erythema in adults: report of two cases and review of the literature. ( 29267450 )
2017
12
Eosinophilic annular erythema localized on the neck. ( 29165308 )
2017
13
Dapsone for Recalcitrant Eosinophilic Annular Erythema: A Case Report and Literature Review. ( 29222624 )
2017
14
Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of SjAPgren syndrome. ( 28771678 )
2017
15
Eosinophilic annular erythema is clinically characterized by central pigmentation reflecting basal melanosis: a clinicopathological study of 10 cases. ( 28543605 )
2017
16
Eosinophilic Annular Erythema Localized to the Palms and the Soles. ( 27904280 )
2016
17
Eosinophilic annular erythema in a patient with autoimmune pancreatitis: Nicotinamide therapy may be beneficial for achieving remission. ( 27129768 )
2016
18
Anti-signal recognition particle antibody-positive polymyositis in a patient with SjAPgren's syndrome showing various types of annular erythema: Positive correlation between the activities of annular erythema and myositis. ( 26972113 )
2016
19
Eosinophilic annular erythema in childhood - Case report. ( 27579748 )
2016
20
Pyoderma gangrenosum and annular erythema associated with SjAPgren's syndrome controlled with minocycline. ( 25899670 )
2015
21
Eosinophilic annular erythema limited on the palms and the soles and possibly associated with thymoma. ( 25816730 )
2015
22
Eosinophilic annular erythema: successful response to ultraviolet B therapy. ( 25958878 )
2015
23
Eosinophilic annular erythema in a patient with metastatic prostate adenocarcinoma. ( 25515818 )
2015
24
Annular erythema in primary Sjogren's syndrome: description of 43 non-Asian cases. ( 24326481 )
2014
25
Eosinophilic annular erythema: attention must be paid. ( 25823085 )
2014
26
Eosinophilic annular erythema is a peculiar subtype in the spectrum of Wells syndrome: a multicentre long-term follow-up study. ( 22731886 )
2013
27
Annular Erythema Associated with SjAPgren's Syndrome Preceding Overlap Syndrome of Rheumatoid Arthritis and Polymyositis with Anti-PL-12 Autoantibodies. ( 24322624 )
2013
28
Annular Erythema and Papules in Infantile Atopic Dermatitis. ( 24202180 )
2013
29
Systemic allergic contact dermatitis to palladium inlay manifesting as annular erythema. ( 22759481 )
2012
30
Eosinophilic annular erythema: an expression of the clinical and pathological polymorphism of Wells syndrome. ( 21920240 )
2011
31
Mycosis fungoides mimicking an annular erythema. ( 19486059 )
2009
32
Eosinophilic annular erythema: a subset of Wells' syndrome or a distinct entity? ( 18638225 )
2008
33
Annular erythema responding to tacrolimus ointment. ( 12884468 )
2003
34
An annular erythema secondary to primary genital herpes. ( 10678482 )
2000
35
The relationship between facial annular erythema and anti-SS-A/Ro antibodies in three East Asian women. ( 10215784 )
1999
36
Analysis of T cell receptor Vbeta repertoires of annular erythema associated with SjAPgren's syndrome. ( 9649694 )
1998
37
Spongiotic annular erythema in SS-A/SS-B antibody negative SjAPgren's syndrome. ( 9563275 )
1998
38
Similar Ro/SS-A autoantibody epitope and titer responses in annular erythema of SjAPgren's syndrome and subacute cutaneous lupus erythematosus. ( 8624149 )
1996
39
Recurrent annular erythema with purpura: a new variant of leucocytoclastic vasculitis responsive to dapsone. ( 8977722 )
1996
40
[Recurrent annular erythema--cutaneous manifestation of SjAPgren syndrome with anti SS-A (Ro) and anti SS-B (La) antibodies]. ( 8531373 )
1995
41
Clinical and immunological analysis of annular erythema associated with SjAPgren syndrome. ( 7519484 )
1994
42
Lymphocyte response to staphylococcal enterotoxin B in patients with annular erythema associated with SjAPgren syndrome. ( 2071745 )
1991
43
Annular erythema. A comparative study of SjAPgren syndrome with subacute cutaneous lupus erythematosus. ( 1938076 )
1991
44
ICAM-1 and LFA-1 expressions in the lesional skin of annular erythema associated with SjAPgren syndrome. ( 1982291 )
1990
45
[Centrifugal annular erythema caused by insect bites]. ( 3320628 )
1987
46
'Persistent' annular erythema of infancy. ( 6465915 )
1984

Variations for Annular Erythema

Expression for Annular Erythema

Search GEO for disease gene expression data for Annular Erythema.

Pathways for Annular Erythema

Pathways related to Annular Erythema according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 HSPG2 ICAM1 ITGB2
2
Show member pathways
12.16 ICAM1 ITGB2
3
Show member pathways
12.09 HSPG2 ICAM1
4
Show member pathways
12.03 ICAM1 ITGB2
5 11.95 ICAM1 ITGB2
6
Show member pathways
11.88 ICAM1 ITGB2
7
Show member pathways
11.79 HSPG2 ICAM1 ITGB2
8 11.67 ICAM1 ITGB2
9
Show member pathways
11.65 HSPG2 ITGB2
10 11.61 ICAM1 ITGB2
11 11.55 ICAM1 ITGB2
12 11.49 ICAM1 ITGB2
13 11.36 ICAM1 ITGB2
14 11.12 ICAM1 ITGB2
15 11.01 ICAM1 ITGB2
16
Show member pathways
10.98 HSPG2 ICAM1 ITGB2
17 10.94 ICAM1 ITGB2
18 10.8 ICAM1 ITGB2

GO Terms for Annular Erythema

Cellular components related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.16 ICAM1 ITGB2
2 extracellular matrix GO:0031012 8.96 HSPG2 ICAM1
3 membrane raft GO:0045121 8.62 ICAM1 ITGB2

Biological processes related to Annular Erythema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 ICAM1 ITGB2
2 regulation of immune response GO:0050776 9.43 ICAM1 ITGB2
3 leukocyte migration GO:0050900 9.4 ICAM1 ITGB2
4 regulation of cell shape GO:0008360 9.37 ICAM1 ITGB2
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.32 ICAM1 ITGB2
6 cell-cell adhesion GO:0098609 9.26 ICAM1 ITGB2
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.16 ICAM1 ITGB2
8 leukocyte cell-cell adhesion GO:0007159 8.96 ICAM1 ITGB2
9 extracellular matrix organization GO:0030198 8.8 HSPG2 ICAM1 ITGB2

Sources for Annular Erythema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....