MCID: AND001
MIFTS: 43

Anodontia

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Anodontia

MalaCards integrated aliases for Anodontia:

Name: Anodontia 12 73 20 29 15 32
Absence of Permanent Teeth 20 6
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 20
Developmental Absence of Tooth 12
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD9CM 34 520.0
MeSH 44 D000848
SNOMED-CT 67 234951001
ICD10 32 K00.0
UMLS 70 C0399352

Summaries for Anodontia

GARD : 20 Anodontia is a dental condition characterized by complete absence of teeth. The primary (baby) or permanent (adult) teeth may be involved. Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified. Treatment involves replacement of the teeth with dentures or implants.

MalaCards based summary : Anodontia, also known as absence of permanent teeth, is related to tooth agenesis, selective, 1 and ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant. An important gene associated with Anodontia is SBDS (SBDS Ribosome Maturation Factor), and among its related pathways/superpathways are TRAF Pathway and Wnt / Hedgehog / Notch. The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and skin, and related phenotypes are craniofacial and growth/size/body region

Disease Ontology : 12 A tooth disease that is characterized by complete absence of permanent teeth.

Wikipedia : 73 Anodontia is a rare genetic disorder characterized by the congenital absence of all primary or permanent... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 tooth agenesis, selective, 1 31.5 PAX9 MSX1 EDA
2 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 30.8 PAX9 EDARADD EDAR EDA2R EDA
3 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 30.8 PAX9 EDARADD EDAR EDA2R EDA
4 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 30.8 PAX9 EDARADD EDAR EDA2R EDA
5 ectodermal dysplasia 1, hypohidrotic, x-linked 30.8 WNT10A EDARADD EDAR EDA2R EDA
6 hypotrichosis 30.3 WNT10A EDARADD EDAR EDA
7 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.3 WNT10A PAX9 MSX1 IKBKG EDARADD EDAR
8 tooth size 30.3 PAX9 MSX1
9 anhidrosis 30.2 IKBKG EDARADD EDAR EDA
10 incontinentia pigmenti 29.6 IKBKG EDAR EDA
11 tooth agenesis 28.0 WNT10A PAX9 MSX1 IKBKG GREM2 EVC2
12 ectodermal dysplasia 28.0 WNT10A MSX1 IKBKG GREM2 EVC2 EVC
13 brachymetapody-anodontia-hypotrichosis-albinoidism 11.2
14 epidermolysis bullosa simplex with anodontia/hypodontia 11.2
15 anodontia of permanent dentition 11.1
16 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.0
17 osteoglophonic dysplasia 10.9
18 cleft lip/palate-ectodermal dysplasia syndrome 10.9
19 ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome 10.9
20 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
21 alopecia 10.2
22 pompholyx 10.2 EDAR EDA
23 taurodontism 10.1 WNT10A EDA
24 atrophic rhinitis 10.1 EDARADD EDA
25 teeth, supernumerary 10.1
26 ankyloglossia with or without tooth anomalies 10.1 PAX9 MSX1
27 witkop syndrome 10.1 PAX9 MSX1 EDAR
28 sweat gland disease 10.1 EDARADD EDAR EDA
29 hair whorl 10.1
30 gapo syndrome 10.1
31 3-methylglutaconic aciduria, type iii 10.1
32 schopf-schulz-passarge syndrome 10.0 WNT10A EDARADD EDAR
33 tooth agenesis, selective, 5 10.0
34 hypohidrotic ectodermal dysplasia autosomal recessive 10.0 WNT10A EDARADD EDAR
35 osteoporosis 10.0
36 bone mineral density quantitative trait locus 8 10.0
37 bone mineral density quantitative trait locus 15 10.0
38 cleft palate, isolated 10.0
39 autosomal recessive disease 10.0
40 keratosis 10.0
41 cleft lip 10.0
42 hidrotic ectodermal dysplasia 2 10.0
43 hair disease 9.9 EDAR EDA ANTXR1
44 ectodermal dysplasia 4, hair/nail type 9.9 EDARADD EDAR
45 physical disorder 9.9 PAX9 MSX1 EVC2
46 androgenic alopecia 9.9 WNT10A EDA2R
47 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 9.9 WNT10A GREM2 EDARADD
48 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.8
49 tooth agenesis, selective, 4 9.8
50 split-hand/foot malformation 1 9.8

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

MGI Mouse Phenotypes related to Anodontia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 10.13 ANTXR1 AXIN2 EDAR EDARADD EVC EVC2
2 growth/size/body region MP:0005378 10.1 ANTXR1 AXIN2 EDAR EDARADD EVC EVC2
3 endocrine/exocrine gland MP:0005379 10.02 ANTXR1 AXIN2 EDAR EDARADD IKBKG MSX1
4 mortality/aging MP:0010768 9.9 ANTXR1 AXIN2 EDAR EDARADD EVC EVC2
5 digestive/alimentary MP:0005381 9.88 EDAR IKBKG MSX1 PAX9 SBDS WNT10A
6 limbs/digits/tail MP:0005371 9.86 AXIN2 EDAR EDARADD EVC EVC2 MSX1
7 normal MP:0002873 9.5 AXIN2 EDA2R EVC2 IKBKG MSX1 PAX9
8 skeleton MP:0005390 9.36 ANTXR1 AXIN2 EDAR EDARADD EVC EVC2

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3 Acetaminophen, hydrocodone drug combination Phase 4
4 Pharmaceutical Solutions Phase 4
5
Cobalt Approved, Experimental 7440-48-4 104729
6
Denosumab Approved 615258-40-7
7
Lithium carbonate Approved 554-13-2
8
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
9 Anesthetics
10 Anti-Bacterial Agents
11 Antibiotics, Antitubercular
12 Diphosphonates
13 Psychotropic Drugs
14 Antidepressive Agents

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 The Effectiveness of the Cytoplast Technique in Preventing Bone Loss Around Immediate Implant Placement in the Esthetic Zone. A Randomized Clinical Trial. Completed NCT01628367 Phase 4 Medications
2 A Phase III, Randomized, Controlled Clinical Trial of Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
3 Evaluation of Retention of Metal Reinforced Polyamide Denture Base Compared to Conventional Heat Cured Acrylic Resin Denture Base in Complete Mandibular Denture Unknown status NCT03385746
4 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
5 Clinical Assessment Of Inlay Retained Bridge Designs (Tub Shaped And Inlay Shaped) In Missing Posterior Teeth Cases. Unknown status NCT03715842
6 A Comparison of Zirconia CAD/CAM and Conventionally Fabricated Single Implant Abutments and Restorations in the Esthetic Zone: a Randomized Controlled Clinical Trial. Unknown status NCT01229995
7 A Single-centre Randomised Controlled Clinical Trial of Zirconia-based Versus Metal-based Adhesive Bridges for Replacing 2 Missing Teeth or Less in Adults. Unknown status NCT01347177
8 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors: A Cross Sectional Study Unknown status NCT03445026
9 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
10 Evaluation of the Effect of Slopped Shoulder Implant Neck Versus Conventional Implant Neck Design on the Crestal Bone Level in the Maxilla: Randomized Clinical Trial (RCT) Unknown status NCT03614442
11 Immediate and Early Loading of Hydrothermally Treated, Hydroxyapatite-Coated Dental Implants:a Controlled Randomized Prospective Clinical Study Unknown status NCT02397044
12 Clinical Study on Zirconia Bridges Unknown status NCT01835834
13 Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer. Unknown status NCT01470235
14 Correlation Study Between Socio-economical Deprivation and Oral Health in in French Children of 9 Years of Age in 2017. A Nationwide Database Retrospective Observational Cohort Study Completed NCT03817437
15 A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth Official Title: Completed NCT02793037
16 The Effect of Platform-Matching Versus Platform-Switching Using Standard Internal Versus Tapered Internal Plus Dental Implants on Peri-implant Hard and Soft Tissue Healing Completed NCT02536716
17 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Completed NCT02239718
18 A Pilot Study Investigating Oral Health Related Quality of Life Improvements in Removable Partial Denture Treatments for the Replacement of Missing Teeth Completed NCT01953991
19 A Comparative, Randomized, Prospective, Clinical Study to Evaluate the Facial Bone and Esthetic Outcome of Buccal Augmentation Bone Grafting Techniques in Early (Type 2) Implant Placement Completed NCT03302143
20 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420
21 Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model Completed NCT03877419
22 REFRAME RPD Post-Market Clinical Study Completed NCT03198520
23 A Histomorphometric Analysis of New Bone Formation Following Sinus Augmentation Using Two Different Bone Graft Materials. A Pilot Study in Humans. Completed NCT03059914
24 A Prospective, Single-Centre, Post-Market Study to Evaluate the Use of Polyetheretherketone (PEEK) Full-Arch Implant-Supported Prostheses in the Edentulous Jaw Recruiting NCT03655990
25 Evaluation Of Innovative 3D Printed Space Maintainer Versus Conventional One Recruiting NCT04221243
26 Evaluation of the Efficacy of Clear Aligners in the Correction of Severe Dental Crowding Cases Combined With Premolar Extraction Versus Vestibular Fixed Orthodontic Appliances: A Randomized Clinical Controlled Trial Recruiting NCT03645356
27 Effect of Neurectomy of Nasopalatine Nerve on Sensation of Anterior Palate in Patient Undergoing Rehabilitation of Atrophic Anterior Maxillary Ridge With Dental Implant Recruiting NCT04153851
28 Dental Rehabilitation of Cancer Patients With Bone Metastases on High Dose Antiresorptives Recruiting NCT04741906
29 Autotransplantation of Teeth With Advanced or Completed Root Development With Intraoperative Extra-corporal Apicoectomy Recruiting NCT04041518
30 Retention and Durability of the Anterior Zirconia Wing Bridge Recruiting NCT04378140
31 Clinical Evaluation of Chairside Computer Assisted Design/Computer Assisted Machining (CAD/CAM) Lithium Disilicate Fixed Partial Dentures (FPD) Active, not recruiting NCT03036566
32 No-preparation Resin Bonded Bridges for the Replacement of Single Missing Teeth Not yet recruiting NCT03029637
33 Alveolar Ridge Expansion by Osseodensification and Its Impact on Implant Survival and Success: A Case Series Not yet recruiting NCT04741594
34 X-space Implants in Post-extraction Sites. A CBCT Randomized Clinical Trial Not yet recruiting NCT04492111
35 Randomized Controlled Clinical Trial of Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia on Titanium Base Abutments or Porcelain-fused to Metal on Gold Abutments Not yet recruiting NCT04713800
36 The Use of Bio-Oss Collagen for Sinus Augmentation Using the Transcrestal Approach. Not yet recruiting NCT04581304
37 Observational, Case-Series Study Evaluation of Bone Width and Dental Implant Stability When Using the Densah Bur™ Bone Compaction Process to Prepare Dental Implant Sites Withdrawn NCT02502058

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

# Genetic test Affiliating Genes
1 Anodontia 29

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

40
Bone, Kidney, Skin

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 475)
# Title Authors PMID Year
1
X-Linked Hypohidrotic Ectodermal Dysplasia in Crossbred Beef Cattle Due to a Large Deletion in EDA. 61
33801223 2021
2
Satisfaction with resilient denture liner versus acrylic resin telescopic prostheses for patients with ectodermal dysplasia: A nonrandomized crossover clinical trial. 61
33674122 2021
3
Ectodermal Dysplasia Presenting as Heat Exhaustion in an Adolescent Boy. 61
33767934 2021
4
No evidence for preferential X-chromosome inactivation as the main cause of divergent phenotypes in sisters with X-linked hypohidrotic ectodermal dysplasia. 61
33622384 2021
5
Managing restorative space, color matching, and tooth replacement with a novel implant through interdisciplinary treatment: A case report of partial anodontia and malformed teeth in the esthetic zone. 61
32945584 2021
6
Bone metabolism of the jaw in response to bisphosphonate: a quantitative analysis of bone scintigraphy images. 61
32140951 2020
7
Case report expanding the germline AXIN2- related phenotype to include olfactory neuroblastoma and gastric adenoma. 61
32807118 2020
8
Genodermatoses with teeth abnormalities. 61
32027427 2020
9
Continuous tooth eruption adjacent to single-implant restorations in the anterior maxilla: aetiology, mechanism and outcomes - A review of the literature. 61
32149398 2020
10
Comprehensive Rehabilitation for a Permanent Tooth Anodontia Patient Using an Integrated Digital Approach. 61
32233191 2020
11
Jaw bones' involvement and dental features of type I and type III Gaucher disease: a radiographic study of 42 paediatric patients. 61
31531808 2020
12
Antxr1, Which is a Target of Runx2, Regulates Chondrocyte Proliferation and Apoptosis. 61
32244499 2020
13
Prosthodontic Management of a Pediatric Patient with Christ-Siemens-Touraine Syndrome: A Case Report. 61
32440077 2019
14
Oral Rehabilitation of a Child with Hypohidrotic Ectodermal Dysplasia. 61
31645258 2019
15
Morphometric analysis of the palatal shape and arch dimension in subjects with palatally displaced canine. 61
30602006 2019
16
Ectodermal dysplasia - A rare case report. 61
31681695 2019
17
Hypodontia, Oligodontia and Anodontia in West Virginia Appalachia. 61
31015306 2019
18
Autotransplantation of premolars and space closure in a patient with inflamed sinuses. 61
30712699 2019
19
Esthetic Rehabilitation of Retained Primary Teeth-A Conservative Approach. 61
28398648 2019
20
Converging physiological roles of the anthrax toxin receptors. 61
31448094 2019
21
Distinct impacts of bi-allelic WNT10A mutations on the permanent and primary dentitions in odonto-onycho-dermal dysplasia. 61
30569517 2019
22
Infrared meibography and molecular assessment of p63 gene mutations in a Mexican patient with EEC syndrome. 61
30025988 2018
23
Patterns of Dental Agenesis Highlight the Nature of the Causative Mutated Genes. 61
29879364 2018
24
Mutation Screening of the EDA Gene in Seven Chinese Families with X-Linked Hypohidrotic Ectodermal Dysplasia. 61
30117778 2018
25
Prosthetic rehabilitation of patients with hypohidrotic ectodermal dysplasia: A systematic review. 61
29679503 2018
26
"Burden of the Triumph:" Burden of peri-implantitis in Indian population - A mathematical model. 61
30127202 2018
27
[Implant prosthesis design scheme for sophisticated congenital partial edentia]. 61
29984941 2018
28
Orthognathic surgery in Melnick-Needles syndrome: a review of the literature and report of two siblings. 61
29336932 2018
29
Unilateral Focal Dermal Hypoplasia (Goltz Syndrome): Case Report and Literature Review. 61
29867430 2018
30
A review on non-syndromic tooth agenesis associated with PAX9 mutations. 61
29628999 2018
31
Oral Care Program for Successful Long-Term Full Mouth Habilitation of Patients with Hypohidrotic Ectodermal Dysplasia. 61
30627453 2018
32
[Hedgehog pathway antagonist-induced oromandibular limb hypogenesis in mouse]. 61
29972962 2018
33
Dental anomalies and lesions in Eastern Atlantic harbor seals, Phoca vitulina vitulina (Carnivora, Phocidae), from the German North Sea. 61
30281623 2018
34
Osteoglophonic Dysplasia: Phenotypic and Radiological Clues. 61
29147600 2017
35
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. 61
29364376 2017
36
Contemporary surgical management of hypodontia. 61
28410841 2017
37
[Morphometric analysis of maxillofacial bone in 48 patients with ectodermal dysplasia]. 61
28815251 2017
38
[Effect of dental arch length decrease during orthodontic treatment in the upper airway development. A review]. 61
28229850 2017
39
Mutation analysis by direct and whole exome sequencing in familial and sporadic tooth agenesis. 61
27665865 2016
40
Fragile X syndrome: panoramic radiographic evaluation of dental anomalies, dental mineralization stage, and mandibular angle. 61
27812623 2016
41
Fell-Muir Lecture: Regulatory mechanisms of skeletal and connective tissue development and homeostasis - lessons from studies of human disorders. 61
27581728 2016
42
Clinical outcomes of implant therapy in ectodermal dysplasia patients: a systematic review. 61
27052318 2016
43
Ectodermal Dysplasia: Management of Knife-Edged Irregular Ridge and Its Rehabilitation with Hybrid Implant Prosthesis. 61
27437373 2016
44
Christ Siemens Touraine syndrome: A rare case report. 61
27080972 2016
45
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. 61
27307674 2016
46
Dental abnormalities after chemotherapy in long-term survivors of childhood acute lymphoblastic leukemia 7-40 years after diagnosis. 61
26361760 2016
47
[Incidence of combination syndrome based on the orthopantomograms made between 2009 és 2014 at the Department of Prosthodontics, University of Pécs, Hungary]. 61
27188158 2016
48
Oculodentodigital dysplasia. 61
27146935 2016
49
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. 61
26759063 2016
50
Diagnosis and Management of a Patient with Congenitally Missing Maxillary First Permanent Molars: A Rare Case Report. 61
27525130 2016

Variations for Anodontia

ClinVar genetic disease variations for Anodontia:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SBDS NM_016038.4(SBDS):c.258+2T>C SNV Pathogenic 3196 rs113993993 GRCh37: 7:66459197-66459197
GRCh38: 7:66994210-66994210
2 SBDS NM_016038.4(SBDS):c.184A>T (p.Lys62Ter) SNV Likely pathogenic 449095 rs120074160 GRCh37: 7:66459273-66459273
GRCh38: 7:66994286-66994286

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 IKBKG EDAR EDA2R EDA
2 11.69 PAX9 MSX1 AXIN2
3
Show member pathways
11.17 EDARADD EDAR EDA2R EDA
4 11.04 IKBKG EDARADD EDAR EDA2R EDA

GO Terms for Anodontia

Cellular components related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane protein complex GO:0098797 8.62 EVC2 EVC

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.67 IKBKG EDAR EDA2R EDA
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.65 IKBKG EDA2R EDA
3 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.63 EDARADD EDAR EDA
4 odontogenesis of dentin-containing tooth GO:0042475 9.61 MSX1 EDAR EDA
5 pigmentation GO:0043473 9.51 EDAR EDA
6 face morphogenesis GO:0060325 9.49 PAX9 MSX1
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 EDARADD EDAR EDA2R EDA
8 hair follicle development GO:0001942 9.43 WNT10A EDAR EDA
9 salivary gland cavitation GO:0060662 9.4 EDAR EDA
10 regulation of odontogenesis GO:0042481 9.32 PAX9 MSX1
11 multicellular organism development GO:0007275 9.28 WNT10A PAX9 MSX1 GREM2 EDARADD EDAR
12 odontogenesis GO:0042476 9.26 WNT10A PAX9 MSX1 AXIN2

Molecular functions related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 EDAR EDA2R ANTXR1
2 receptor ligand activity GO:0048018 8.8 WNT10A GREM2 EDA

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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