MCID: AND001
MIFTS: 46

Anodontia

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Anodontia

MalaCards integrated aliases for Anodontia:

Name: Anodontia 12 76 53 29 15
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 53
Developmental Absence of Tooth 12
Absence of Permanent Teeth 53
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD10 33 K00.0
ICD9CM 35 520.0
MeSH 44 D000848
UMLS 73 C0399352

Summaries for Anodontia

NIH Rare Diseases : 53 Anodontia is a dental condition characterized by complete absence of teeth. The primary (baby) or permanent (adult) teeth may be involved. Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified. Treatment involves replacement of the teeth with dentures or implants.

MalaCards based summary : Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant and ectodermal dysplasia. An important gene associated with Anodontia is PAX9 (Paired Box 9), and among its related pathways/superpathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotypes are anodontia and craniofacial

Wikipedia : 76 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 31.1 EDAR EDARADD
2 ectodermal dysplasia 30.5 EDAR EDARADD
3 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 30.1 EDAR EDARADD MSX1 PAX9
4 hypotrichosis 29.7 EDAR EDARADD
5 tooth agenesis 29.5 AXIN2 EDAR EDARADD MSX1 PAX9
6 cleft lip 29.3 MSX1 PAX9
7 anodontia of permanent dentition 12.1
8 brachymetapody-anodontia-hypotrichosis-albinoidism 12.0
9 epidermolysis bullosa simplex with anodontia/hypodontia 11.9
10 aloi tomasini isaia syndrome 11.4
11 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.2
12 ectodermal dysplasia 1, hypohidrotic, x-linked 11.2
13 tooth agenesis, selective, 1 10.9
14 cleft lip/palate-ectodermal dysplasia syndrome 10.9
15 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.9
16 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.9
17 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
18 zlotogora syndrome 10.9
19 hypohidrotic ectodermal dysplasia autosomal recessive 10.0 EDAR EDARADD
20 tooth size 10.0 MSX1 PAX9
21 mouth disease 9.9 MSX1 PAX9
22 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.8
23 teeth, supernumerary 9.8
24 gapo syndrome 9.8
25 3-methylglutaconic aciduria, type iii 9.8
26 rothmund-thomson syndrome 9.8
27 incontinentia pigmenti 9.8
28 erythrokeratodermia variabilis et progressiva 5 9.8
29 alopecia 9.8
30 anhidrosis 9.8
31 ankylosis 9.8
32 epidermolysis bullosa 9.8
33 epidermolysis bullosa simplex 9.8
34 waardenburg's syndrome 9.8
35 medullary sponge kidney 9.8
36 mosaic trisomy 13 9.8
37 orofacial cleft 9.6 MSX1 PAX9
38 clouston syndrome 9.4 ANTXR1 EDAR EDARADD
39 cleft palate, isolated 9.4 MSX1 PAX9
40 hypohidrosis 9.3 EDAR EDARADD MSX1
41 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 7.8 AXIN2 EDAR EDARADD MSX1 PAX9

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

Human phenotypes related to Anodontia:

32
# Description HPO Frequency HPO Source Accession
1 anodontia 32 hallmark (90%) HP:0000674

MGI Mouse Phenotypes related to Anodontia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.91 ANTXR1 AXIN2 EDAR EDARADD MSX1 PAX9
2 endocrine/exocrine gland MP:0005379 9.88 AXIN2 EDAR EDARADD MSX1 PAX9 ANTXR1
3 growth/size/body region MP:0005378 9.85 ANTXR1 AXIN2 EDAR EDARADD MSX1 PAX9
4 mortality/aging MP:0010768 9.73 ANTXR1 AXIN2 EDAR EDARADD MSX1 PAX9
5 limbs/digits/tail MP:0005371 9.72 AXIN2 EDAR EDARADD MSX1 PAX9
6 reproductive system MP:0005389 9.55 ANTXR1 AXIN2 EDAR EDARADD PAX9
7 skeleton MP:0005390 9.43 ANTXR1 AXIN2 EDAR EDARADD MSX1 PAX9
8 vision/eye MP:0005391 8.92 EDAR EDARADD MSX1 AXIN2

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
4
Cetylpyridinium Approved Phase 4 7773-52-6
5 Acetaminophen, hydrocodone drug combination Phase 4
6 Pharmaceutical Solutions Phase 4
7 Anti-Infective Agents Phase 4,Not Applicable
8 Anti-Infective Agents, Local Phase 4,Not Applicable
9
Cobalt Phase 1, Phase 2,Not Applicable 7440-48-4 104729
10 Micronutrients Phase 1, Phase 2
11 Trace Elements Phase 1, Phase 2
12 Tea Nutraceutical Phase 2
13
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
14
Flurbiprofen Approved, Investigational Early Phase 1 5104-49-4 3394
15
Cimetidine Approved, Investigational Not Applicable 51481-61-9 2756
16
Histamine Approved, Investigational Not Applicable 75614-87-8, 51-45-6 774
17 Calcium, Dietary Not Applicable
18 Mitogens Not Applicable
19 Analgesics Not Applicable,Early Phase 1
20 Analgesics, Non-Narcotic Not Applicable,Early Phase 1
21 Anti-Inflammatory Agents Not Applicable,Early Phase 1
22 Anti-Inflammatory Agents, Non-Steroidal Not Applicable,Early Phase 1
23 Antirheumatic Agents Not Applicable,Early Phase 1
24 Carbon fiber Not Applicable
25 Peripheral Nervous System Agents Not Applicable,Early Phase 1
26 Antidepressive Agents Not Applicable
27 Antimanic Agents Not Applicable
28 Central Nervous System Depressants Not Applicable
29 Lithium carbonate Not Applicable 554-13-2
30 Psychotropic Drugs Not Applicable
31 Tranquilizing Agents Not Applicable
32 Cyclooxygenase Inhibitors Early Phase 1
33 Antacids Not Applicable
34 Anti-Ulcer Agents Not Applicable
35 Cytochrome P-450 CYP1A2 Inhibitors Not Applicable
36 Cytochrome P-450 Enzyme Inhibitors Not Applicable
37 Gastrointestinal Agents Not Applicable
38 Histamine Antagonists Not Applicable
39 Histamine H2 Antagonists Not Applicable
40
Histamine Phosphate Not Applicable 51-74-1 65513
41 Neurotransmitter Agents Not Applicable

Interventional clinical trials:

(show top 50) (show all 66)
# Name Status NCT ID Phase Drugs
1 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4 Medications
2 The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Completed NCT00868777 Phase 4
3 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
4 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
5 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Recruiting NCT02158377 Phase 4
6 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
7 Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development Unknown status NCT00466414 Phase 2
8 Interventions for Patients With a Shortened Dental Arch Completed NCT01597206 Phase 1, Phase 2
9 Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design Completed NCT02761226 Phase 2
10 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
11 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
12 Clinical Trial of Zirconia and Metal Adhesive Bridges Unknown status NCT01347177 Not Applicable
13 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
14 Hypodontia and Ovarian Cancer Unknown status NCT01470235
15 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Unknown status NCT02397044
16 Clinical Study on Zirconia Bridges Unknown status NCT01835834 Not Applicable
17 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
18 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995 Not Applicable
19 Vertical Augmentation With Osteon at Dental Implant Placement Unknown status NCT01162629
20 Stability of Implants With Different Surface Treatment: Randomized Clinical Trial Unknown status NCT01699568 Not Applicable
21 Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries Unknown status NCT02056262
22 OHQoL With Removable Partial Dentures; a Pilot Study Completed NCT01953991 Not Applicable
23 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420 Not Applicable
24 Radiographic and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement Completed NCT03302143 Not Applicable
25 Effect of Implant Thread Design on Implant Stability Quotient (ISQ) in Early Healing Period Completed NCT02701387 Not Applicable
26 Chewing Side Preference and Hemispheric Laterality in Healthy Adults Completed NCT03054246 Not Applicable
27 Risk Factors for Implant Bone Loss in Patients With Diabetes Mellitus Completed NCT00933491
28 An Assessment of Bone Augmentation in Post-Extraction Sockets Completed NCT00641316 Not Applicable
29 Esthetic Outcomes of Immediately Placed Implants Receiving Immediate Provisionalization and Delayed Restoration Completed NCT01925339 Not Applicable
30 Longitudinal Efficacy of Dental Implants in Anterior Areas Completed NCT00641277
31 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Completed NCT01603693 Not Applicable
32 Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects Completed NCT00001211
33 Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft Completed NCT01924390 Not Applicable
34 Evaluation of the ACE Dental Implant Completed NCT00641576
35 Electromyographic Estimation of Neuro-muscular Coordination of Masticatory Muscles in Patients Treated With Implants (D-2012-057) Completed NCT03415971 Not Applicable
36 Oral Health and People With Systemic Sclerosis Completed NCT01817361
37 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718 Not Applicable
38 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311 Not Applicable
39 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Recruiting NCT03059914 Not Applicable
40 REFRAME RPD Post-Market Clinical Study Recruiting NCT03198520 Not Applicable
41 Long Term Dental Effects in Adolescents Who Were Treated for Cancer in Childhood Recruiting NCT02742363
42 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors Study Recruiting NCT03445026
43 Temporary Anchorage Devices for Ridge Preservation Recruiting NCT03205800 Not Applicable
44 Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study Recruiting NCT03100435 Not Applicable
45 Oral Health for Healthy Cognitive Aging Recruiting NCT02986386 Not Applicable
46 Program to Improve Dental Care: Children With ASD Recruiting NCT03546504 Not Applicable
47 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
48 The Effect of Platform-Matching Versus Platform-Switching Dental Implants on Peri-implant Hard and Soft Tissue Healing Active, not recruiting NCT02536716 Not Applicable
49 Lithium Disilicate (CAD/CAM) Fixed Partial Dentures (FPD) Clinical Study Active, not recruiting NCT03036566 Not Applicable
50 The Clinical Performance of Inlay Zirconia Bridges Active, not recruiting NCT02995876 Not Applicable

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

# Genetic test Affiliating Genes
1 Anodontia 29

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

41
Bone, Skin, Kidney, Liver

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 115)
# Title Authors Year
1
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. ( 29364376 )
2017
2
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
3
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. ( 27307674 )
2016
4
Dental management of Rothmund-Thomson syndrome with partial anodontia. ( 26032705 )
2015
5
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. ( 23857653 )
2013
6
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. ( 23919206 )
2013
7
Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia. ( 25206157 )
2012
8
Total anodontia in patient with hypohidrotic ectodermal dysplasia. Report of rare case of Christ-Siemens Touraine syndrome. ( 21417166 )
2011
9
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. ( 22090765 )
2011
10
Ectodermal dysplasia with true anodontia. ( 22529591 )
2011
11
Ectodermal dysplasia with anodontia: a report of two cases. ( 20396456 )
2010
12
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. ( 23204727 )
2010
13
Congenital oligodontia of the deciduous teeth and anodontia of the permanent teeth in a cat. ( 18835802 )
2009
14
Congenital anodontia in ectodermal dysplasia. ( 19189682 )
2008
15
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. ( 19008629 )
2008
16
Congenital hypotrichosis and partial anodontia in a crossbred beef calf. ( 17616058 )
2007
17
Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition. ( 18197325 )
2007
18
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. ( 17216912 )
2007
19
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. ( 16891749 )
2006
20
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. ( 12464063 )
2002
21
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. ( 12397238 )
2002
22
Ectodermal dysplasia with total anodontia: rehabilitation of a seven year old child. ( 12435010 )
2002
23
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. ( 12413164 )
2002
24
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. ( 11314218 )
2001
25
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). ( 11763226 )
2001
26
Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. ( 10730287 )
2000
27
Partial anodontia in a case of Waardenburg's syndrome. ( 10605569 )
1999
28
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. ( 10431618 )
1999
29
Primary tuberculous liver abscess associated with progressive symmetric erythrokeratodermia, anodontia and ectodermal dysplasias. ( 9828554 )
1998
30
Implant-supported prosthesis in a child with hereditary mandibular anodontia: the use of ball attachments. ( 9558550 )
1998
31
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. ( 9617452 )
1998
32
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. ( 9477872 )
1997
33
Prosthetic rehabilitation of a child with induced anodontia. ( 8634197 )
1995
34
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. ( 7568733 )
1995
35
Treating severe partial anodontia: a 10-year history of patient treatment. ( 7798481 )
1994
36
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. ( 1629447 )
1992
37
Anodontia associated with hypohidrotic ectodermal dysplasia. ( 1344283 )
1992
38
Overdentures in partial anodontia: simple solutions for complex problems. ( 1860126 )
1991
39
Anodontia of the permanent dentition: fourteen years after initial diagnosis. ( 2319058 )
1990
40
Complete anodontia of the permanent dentition: case report. ( 2133936 )
1990
41
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. ( 2346400 )
1990
42
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. ( 2097249 )
1990
43
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. ( 2222925 )
1990
44
[Absence of permanent teeth buds in three generations of a family]. ( 2104354 )
1990
45
Unilateral linear basal cell nevus associated with diffuse osteoma cutis, unilateral anodontia, and abnormal bone mineralization. ( 2715453 )
1989
46
Partial anodontia: a case report. ( 2598201 )
1989
47
Congenital partial anodontia: prosthodontic considerations. ( 3250573 )
1988
48
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. ( 3045169 )
1988
49
A genetic, pathological and virological study of congenital hypotrichosis and incisor anodontia in cattle. ( 2836985 )
1988
50
Familial medullary sponge kidney in association with congenital absence of teeth (anodontia). ( 3352850 )
1988

Variations for Anodontia

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 AXIN2 MSX1
2 11.06 AXIN2 MSX1 PAX9
3 10.43 EDAR EDARADD

GO Terms for Anodontia

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.55 AXIN2 EDAR EDARADD MSX1 PAX9
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.37 EDAR EDARADD
3 odontogenesis of dentin-containing tooth GO:0042475 9.32 EDAR MSX1
4 face morphogenesis GO:0060325 9.26 MSX1 PAX9
5 regulation of odontogenesis GO:0042481 8.96 MSX1 PAX9
6 odontogenesis GO:0042476 8.8 AXIN2 MSX1 PAX9

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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