MCID: AND001
MIFTS: 44

Anodontia

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Anodontia

MalaCards integrated aliases for Anodontia:

Name: Anodontia 12 77 54 30 15
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 54
Developmental Absence of Tooth 12
Absence of Permanent Teeth 54
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD9CM 36 520.0
MeSH 45 D000848
SNOMED-CT 69 16958000 26624006
ICD10 34 K00.0
UMLS 74 C0399352

Summaries for Anodontia

NIH Rare Diseases : 54 Anodontia is a dental condition characterized by complete absence of teeth. The primary (baby) or permanent (adult) teeth may be involved. Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified. Treatment involves replacement of the teeth with dentures or implants.

MalaCards based summary : Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to tooth agenesis and ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive. An important gene associated with Anodontia is PAX9 (Paired Box 9), and among its related pathways/superpathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotypes are anodontia and craniofacial

Wikipedia : 77 Anodontia is a rare genetic disorder characterized by the congenital absence of all primary or permanent... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 tooth agenesis 31.4 AXIN2 EDA EDARADD MSX1 PAX9
2 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 31.2 EDA EDARADD MSX1 PAX9
3 ectodermal dysplasia 30.9 EDA EDARADD
4 cleft lip 29.7 MSX1 PAX9
5 anodontia of permanent dentition 12.3
6 brachymetapody-anodontia-hypotrichosis-albinoidism 12.2
7 epidermolysis bullosa simplex with anodontia/hypodontia 12.1
8 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.4
9 ectodermal dysplasia 1, hypohidrotic, x-linked 11.4
10 tooth agenesis, selective, 1 11.1
11 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 11.1
12 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 11.1
13 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 11.1
14 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 11.1
15 zlotogora syndrome 11.1
16 hypotrichosis 10.3
17 teeth, supernumerary 10.1
18 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.0
19 split-hand/foot malformation 1 10.0
20 gapo syndrome 10.0
21 3-methylglutaconic aciduria, type iii 10.0
22 rothmund-thomson syndrome 10.0
23 incontinentia pigmenti 10.0
24 erythrokeratodermia variabilis et progressiva 5 10.0
25 alopecia 10.0
26 anhidrosis 10.0
27 patau syndrome 10.0
28 ankylosis 10.0
29 epidermolysis bullosa 10.0
30 epidermolysis bullosa simplex 10.0
31 waardenburg's syndrome 10.0
32 medullary sponge kidney 10.0
33 isolated split hand-split foot malformation 10.0
34 tooth size 10.0 MSX1 PAX9
35 mouth disease 9.9 MSX1 PAX9
36 cleft palate, isolated 9.7 MSX1 PAX9
37 clouston syndrome 9.6 ANTXR1 EDA EDARADD
38 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 9.2 AXIN2 EDARADD MSX1 PAX9

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

Human phenotypes related to Anodontia:

33
# Description HPO Frequency HPO Source Accession
1 anodontia 33 hallmark (90%) HP:0000674

MGI Mouse Phenotypes related to Anodontia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.77 ANTXR1 AXIN2 EDARADD MSX1 PAX9
2 endocrine/exocrine gland MP:0005379 9.72 ANTXR1 AXIN2 EDARADD MSX1 PAX9
3 growth/size/body region MP:0005378 9.65 ANTXR1 AXIN2 EDARADD MSX1 PAX9
4 hearing/vestibular/ear MP:0005377 9.33 EDARADD MSX1 PAX9
5 limbs/digits/tail MP:0005371 9.26 AXIN2 EDARADD MSX1 PAX9
6 skeleton MP:0005390 9.02 ANTXR1 AXIN2 EDARADD MSX1 PAX9

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Cetylpyridinium Approved Phase 4 7773-52-6
4 Pharmaceutical Solutions Phase 4
5 Acetaminophen, hydrocodone drug combination Phase 4
6 Anti-Infective Agents, Local Phase 4,Not Applicable
7 Anti-Infective Agents Phase 4,Not Applicable
8 Z 350 Phase 3
9
Cobalt Approved, Experimental Phase 1, Phase 2,Not Applicable 7440-48-4 104729
10 Trace Elements Phase 1, Phase 2
11 Nutrients Phase 1, Phase 2
12 Micronutrients Phase 1, Phase 2
13 Tea Phase 2
14
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
15
Lithium carbonate Approved Not Applicable 554-13-2
16
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
17
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
18
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
19
Racepinephrine Approved Not Applicable 329-65-7 838
20
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
21
Flurbiprofen Approved, Investigational Early Phase 1 5104-49-4 3394
22
Histamine Approved, Investigational Not Applicable 51-45-6 774
23
Cimetidine Approved, Investigational Not Applicable 51481-61-9 2756
24
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
25
Lobeline Investigational 90-69-7
26 Mitogens Not Applicable
27 Calcium, Dietary Not Applicable
28 Hormones Not Applicable
29 Central Nervous System Stimulants Not Applicable
30 Peripheral Nervous System Agents Not Applicable,Early Phase 1
31 Neurotransmitter Uptake Inhibitors Not Applicable
32 Adrenergic Agents Not Applicable
33 Neurotransmitter Agents Not Applicable
34 Dopamine Agents Not Applicable
35 Sympathomimetics Not Applicable
36 Dopamine Uptake Inhibitors Not Applicable
37 Autonomic Agents Not Applicable
38 Carbon Fiber Not Applicable
39 Epinephryl borate Not Applicable
40 Tranquilizing Agents Not Applicable
41 Antidepressive Agents Not Applicable
42 Central Nervous System Depressants Not Applicable
43 Antimanic Agents Not Applicable
44 Psychotropic Drugs Not Applicable
45 Buchu Not Applicable
46 Keratolytic Agents Not Applicable
47 Antifungal Agents Not Applicable
48 Dermatologic Agents Not Applicable
49 Anesthetics ,Not Applicable
50 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1

Interventional clinical trials:

(show top 50) (show all 86)
# Name Status NCT ID Phase Drugs
1 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Unknown status NCT02158377 Phase 4
2 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4 Medications
3 The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Completed NCT00868777 Phase 4
4 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
5 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
6 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
7 Impact of Patients Risk Factors on the Longevity of Aesthetic Restorations Active, not recruiting NCT03834636 Phase 3
8 Pontic Site Development Using Soft Tissue Augmentation Not yet recruiting NCT03834649 Phase 3
9 Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development Unknown status NCT00466414 Phase 2
10 Interventions for Patients With a Shortened Dental Arch Completed NCT01597206 Phase 1, Phase 2
11 Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design Completed NCT02761226 Phase 2
12 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
13 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
14 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Active, not recruiting NCT03059914 Phase 1
15 Clinical Trial of Zirconia and Metal Adhesive Bridges Unknown status NCT01347177 Not Applicable
16 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
17 Hypodontia and Ovarian Cancer Unknown status NCT01470235
18 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Unknown status NCT02397044
19 Clinical Study on Zirconia Bridges Unknown status NCT01835834 Not Applicable
20 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
21 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995 Not Applicable
22 Vertical Augmentation With Osteon at Dental Implant Placement Unknown status NCT01162629
23 Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants Unknown status NCT02937220 Not Applicable
24 Stability of Implants With Different Surface Treatment: Randomized Clinical Trial Unknown status NCT01699568 Not Applicable
25 Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries Unknown status NCT02056262
26 OHQoL With Removable Partial Dentures; a Pilot Study Completed NCT01953991 Not Applicable
27 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420 Not Applicable
28 Sonographic Imaging of Oral and Dental Anatomical Structures (A Pilot Study) Completed NCT03657589
29 Radiographic and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement Completed NCT03302143 Not Applicable
30 Effect of Implant Thread Design on Implant Stability Quotient (ISQ) in Early Healing Period Completed NCT02701387 Not Applicable
31 Chewing Side Preference and Hemispheric Laterality in Healthy Adults Completed NCT03054246 Not Applicable
32 The Clinical Performance of Inlay Zirconia Bridges Completed NCT02995876 Not Applicable
33 Risk Factors for Implant Bone Loss in Patients With Diabetes Mellitus Completed NCT00933491
34 Perception of Children With Visible Untreated and Treated Caries Completed NCT02899273
35 An Assessment of Bone Augmentation in Post-Extraction Sockets Completed NCT00641316 Not Applicable
36 Esthetic Outcomes of Immediately Placed Implants Receiving Immediate Provisionalization and Delayed Restoration Completed NCT01925339 Not Applicable
37 Longitudinal Efficacy of Dental Implants in Anterior Areas Completed NCT00641277
38 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Completed NCT01603693 Not Applicable
39 An Implant With an Acid-etched Fixture Surface and Internal-hex Collar May Achieve Greater Osseointegration. Completed NCT01641198 Not Applicable
40 Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects Completed NCT00001211
41 Effects of Fixed and Removable Space Maintainers on Periodontal Health and DMFT/Dft Values Completed NCT03608345
42 Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft Completed NCT01924390 Not Applicable
43 Evaluation of the ACE Dental Implant Completed NCT00641576
44 Electromyographic Estimation of Neuro-muscular Coordination of Masticatory Muscles in Patients Treated With Implants (D-2012-057) Completed NCT03415971 Not Applicable
45 Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study Completed NCT03614871
46 Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden Completed NCT03918902
47 Oral Health and People With Systemic Sclerosis Completed NCT01817361
48 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718 Not Applicable
49 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311 Not Applicable
50 A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA Recruiting NCT03655990

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

# Genetic test Affiliating Genes
1 Anodontia 30

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

42
Bone, Skin, Kidney, Liver

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 122)
# Title Authors Year
1
Hypodontia, Oligodontia and Anodontia in West Virginia Appalachia. ( 31015306 )
2019
2
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. ( 29364376 )
2017
3
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
4
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. ( 27307674 )
2016
5
Dental management of Rothmund-Thomson syndrome with partial anodontia. ( 26032705 )
2015
6
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. ( 23857653 )
2013
7
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. ( 23919206 )
2013
8
Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia. ( 25206157 )
2012
9
Total anodontia in patient with hypohidrotic ectodermal dysplasia. Report of rare case of Christ-Siemens Touraine syndrome. ( 21417166 )
2011
10
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. ( 22090765 )
2011
11
Ectodermal dysplasia with true anodontia. ( 22529591 )
2011
12
Ectodermal dysplasia with anodontia: a report of two cases. ( 20396456 )
2010
13
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. ( 23204727 )
2010
14
Congenital oligodontia of the deciduous teeth and anodontia of the permanent teeth in a cat. ( 18835802 )
2009
15
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. ( 19008629 )
2008
16
Congenital anodontia in ectodermal dysplasia. ( 19189682 )
2008
17
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. ( 17216912 )
2007
18
Congenital hypotrichosis and partial anodontia in a crossbred beef calf. ( 17616058 )
2007
19
Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition. ( 18197325 )
2007
20
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. ( 16891749 )
2006
21
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. ( 12397238 )
2002
22
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. ( 12413164 )
2002
23
Ectodermal dysplasia with total anodontia: rehabilitation of a seven year old child. ( 12435010 )
2002
24
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. ( 12464063 )
2002
25
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. ( 11314218 )
2001
26
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). ( 11763226 )
2001
27
Anodontia of permanent teeth (OMIM # 206780) and pegged/missing maxillary lateral incisors (OMIM # 150400) in the same family. ( 10710232 )
2000
28
Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. ( 10730287 )
2000
29
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. ( 10431618 )
1999
30
Partial anodontia in a case of Waardenburg's syndrome. ( 10605569 )
1999
31
Implant-supported prosthesis in a child with hereditary mandibular anodontia: the use of ball attachments. ( 9558550 )
1998
32
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. ( 9617452 )
1998
33
Primary tuberculous liver abscess associated with progressive symmetric erythrokeratodermia, anodontia and ectodermal dysplasias. ( 9828554 )
1998
34
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. ( 9477872 )
1997
35
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. ( 7568733 )
1995
36
Prosthetic rehabilitation of a child with induced anodontia. ( 8634197 )
1995
37
Treating severe partial anodontia: a 10-year history of patient treatment. ( 7798481 )
1994
38
Longitudinal study of jaw growth and prosthetic management in a patient with ectodermal dysplasia and anodontia. ( 8329334 )
1993
39
Anodontia associated with hypohidrotic ectodermal dysplasia. ( 1344283 )
1992
40
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. ( 1629447 )
1992
41
Overdentures in partial anodontia: simple solutions for complex problems. ( 1860126 )
1991
42
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. ( 2097249 )
1990
43
Complete anodontia of the permanent dentition: case report. ( 2133936 )
1990
44
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. ( 2222925 )
1990
45
Anodontia of the permanent dentition: fourteen years after initial diagnosis. ( 2319058 )
1990
46
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. ( 2346400 )
1990
47
[Absence of permanent teeth buds in three generations of a family]. ( 2104354 )
1990
48
Partial anodontia: a case report. ( 2598201 )
1989
49
Unilateral linear basal cell nevus associated with diffuse osteoma cutis, unilateral anodontia, and abnormal bone mineralization. ( 2715453 )
1989
50
A genetic, pathological and virological study of congenital hypotrichosis and incisor anodontia in cattle. ( 2836985 )
1988

Variations for Anodontia

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 AXIN2 MSX1
2 11.06 AXIN2 MSX1 PAX9
3 10.43 EDA EDARADD

GO Terms for Anodontia

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.55 AXIN2 EDA EDARADD MSX1 PAX9
2 positive regulation of canonical Wnt signaling pathway GO:0090263 9.4 AXIN2 EDA
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.37 EDA EDARADD
4 odontogenesis of dentin-containing tooth GO:0042475 9.32 EDA MSX1
5 face morphogenesis GO:0060325 9.26 MSX1 PAX9
6 regulation of odontogenesis GO:0042481 8.96 MSX1 PAX9
7 odontogenesis GO:0042476 8.8 AXIN2 MSX1 PAX9

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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