MCID: AND001
MIFTS: 39

Anodontia

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Anodontia

MalaCards integrated aliases for Anodontia:

Name: Anodontia 12 76 53 29 15
Total Anodontia of Permanent and Deciduous Teeth 12
Anodontia of Permanent Dentition 53
Developmental Absence of Tooth 12
Absence of Permanent Teeth 53
Complete Absence of Teeth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13714
ICD10 33 K00.0
ICD9CM 35 520.0
MeSH 44 D000848
SNOMED-CT 68 16958000 26624006
UMLS 73 C0399352

Summaries for Anodontia

NIH Rare Diseases : 53 Anodontia is a dental condition characterized by complete absence of teeth. The primary (baby) or permanent (adult) teeth may be involved. Anodontia is extremely rare when present in a pure form (without associated abnormalities). In most cases, the phenomenon is associated with a group of conditions called the ectodermal dysplasias. In these cases, abnormalities are also noted in the hair, nails, and sweat glands. Anodontia is an autosomal recessive condition. A specific gene has not yet been identified. Treatment involves replacement of the teeth with dentures or implants.

MalaCards based summary : Anodontia, also known as total anodontia of permanent and deciduous teeth, is related to tooth agenesis and ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive. An important gene associated with Anodontia is PAX9 (Paired Box 9), and among its related pathways/superpathways are Neural Crest Differentiation and Wnt / Hedgehog / Notch. The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver, and related phenotypes are anodontia and craniofacial

Wikipedia : 76 In dentistry, anodontia, also called anodontia vera, is a rare genetic disorder characterized by the... more...

Related Diseases for Anodontia

Diseases related to Anodontia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 tooth agenesis 31.9 AXIN2 EDA EDARADD MSX1 PAX9
2 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 31.5 EDA EDARADD MSX1 PAX9
3 ectodermal dysplasia 30.9 EDA EDARADD
4 hypotrichosis 30.3 EDA EDARADD
5 cleft lip 29.8 MSX1 PAX9
6 anodontia of permanent dentition 12.2
7 brachymetapody-anodontia-hypotrichosis-albinoidism 12.1
8 epidermolysis bullosa simplex with anodontia/hypodontia 12.0
9 aloi tomasini isaia syndrome 11.6
10 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.4
11 ectodermal dysplasia 1, hypohidrotic, x-linked 11.3
12 tooth agenesis, selective, 1 11.0
13 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 11.0
14 cleft lip/palate-ectodermal dysplasia syndrome 11.0
15 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 11.0
16 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 11.0
17 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 11.0
18 zlotogora syndrome 11.0
19 teeth, supernumerary 10.1
20 tooth size 10.0 MSX1 PAX9
21 mouth disease 10.0 MSX1 PAX9
22 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.9
23 gapo syndrome 9.9
24 3-methylglutaconic aciduria, type iii 9.9
25 rothmund-thomson syndrome 9.9
26 incontinentia pigmenti 9.9
27 erythrokeratodermia variabilis et progressiva 5 9.9
28 alopecia 9.9
29 anhidrosis 9.9
30 ankylosis 9.9
31 epidermolysis bullosa 9.9
32 epidermolysis bullosa simplex 9.9
33 waardenburg's syndrome 9.9
34 medullary sponge kidney 9.9
35 orofacial cleft 9.9 MSX1 PAX9
36 cleft palate, isolated 9.8 MSX1 PAX9
37 clouston syndrome 9.8 ANTXR1 EDA EDARADD
38 hypohidrosis 9.7 EDA EDARADD MSX1
39 fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly 9.5 AXIN2 EDARADD MSX1 PAX9

Graphical network of the top 20 diseases related to Anodontia:



Diseases related to Anodontia

Symptoms & Phenotypes for Anodontia

Human phenotypes related to Anodontia:

32
# Description HPO Frequency HPO Source Accession
1 anodontia 32 hallmark (90%) HP:0000674

MGI Mouse Phenotypes related to Anodontia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.77 ANTXR1 AXIN2 EDARADD MSX1 PAX9
2 endocrine/exocrine gland MP:0005379 9.72 ANTXR1 AXIN2 EDARADD MSX1 PAX9
3 growth/size/body region MP:0005378 9.65 ANTXR1 AXIN2 EDARADD MSX1 PAX9
4 hearing/vestibular/ear MP:0005377 9.33 EDARADD MSX1 PAX9
5 limbs/digits/tail MP:0005371 9.26 AXIN2 EDARADD MSX1 PAX9
6 skeleton MP:0005390 9.02 ANTXR1 AXIN2 EDARADD MSX1 PAX9

Drugs & Therapeutics for Anodontia

Drugs for Anodontia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Cetylpyridinium Approved Phase 4 7773-52-6
4 Acetaminophen, hydrocodone drug combination Phase 4
5 Pharmaceutical Solutions Phase 4
6 Anti-Infective Agents Phase 4,Not Applicable
7 Anti-Infective Agents, Local Phase 4,Not Applicable
8
Cobalt Approved, Experimental Phase 1, Phase 2,Not Applicable 7440-48-4 104729
9 Micronutrients Phase 1, Phase 2
10 Trace Elements Phase 1, Phase 2
11 Tea Phase 2
12
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
13
Lithium carbonate Approved Not Applicable 554-13-2
14
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
15
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
16
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
17
Racepinephrine Approved Not Applicable 329-65-7 838
18
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
19
Flurbiprofen Approved, Investigational Early Phase 1 5104-49-4 3394
20
Histamine Approved, Investigational Not Applicable 51-45-6, 75614-87-8 774
21
Cimetidine Approved, Investigational Not Applicable 51481-61-9 2756
22 Mitogens Not Applicable
23 Calcium, Dietary Not Applicable
24 Peripheral Nervous System Agents Not Applicable,Early Phase 1
25 Sympathomimetics Not Applicable
26 Dopamine Agents Not Applicable
27 Autonomic Agents Not Applicable
28 Neurotransmitter Uptake Inhibitors Not Applicable
29 Adrenergic Agents Not Applicable
30 Dopamine Uptake Inhibitors Not Applicable
31 Central Nervous System Stimulants Not Applicable
32 Neurotransmitter Agents Not Applicable
33 Analgesics, Non-Narcotic Not Applicable,Early Phase 1
34 Analgesics Not Applicable,Early Phase 1
35 Antirheumatic Agents Not Applicable,Early Phase 1
36 Anti-Inflammatory Agents, Non-Steroidal Not Applicable,Early Phase 1
37 Anti-Inflammatory Agents Not Applicable,Early Phase 1
38 Carbon fiber Not Applicable
39 Epinephryl borate Not Applicable
40 Central Nervous System Depressants Not Applicable
41 Psychotropic Drugs Not Applicable
42 Antidepressive Agents Not Applicable
43 Tranquilizing Agents Not Applicable
44 Antimanic Agents Not Applicable
45 Dermatologic Agents Not Applicable
46 Keratolytic Agents Not Applicable
47 Antifungal Agents Not Applicable
48 Buchu Not Applicable
49 Cyclooxygenase Inhibitors Early Phase 1
50 Histamine H2 Antagonists Not Applicable

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 TM vs TSV Implants Loaded Early vs Conventional in Anterior and Posterior Areas Unknown status NCT02158377 Phase 4
2 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4 Medications
3 The Influence of Dimensional Anatomic Variables on the Outcomes of Maxillary Sinus Grafting Procedures Completed NCT00868777 Phase 4
4 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
5 Peri-implant Bone Changes in Post-menopausal Osteoporotic Women Recruiting NCT02884401 Phase 4
6 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
7 Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development Unknown status NCT00466414 Phase 2
8 Interventions for Patients With a Shortened Dental Arch Completed NCT01597206 Phase 1, Phase 2
9 Clinical and Radiographic Evaluation of Crestal Bone Loss Around Implant With or Without Platform Switching Design Completed NCT02761226 Phase 2
10 A Phase II Trial to Assess the Effects of Green Tea in Oral Leukoplakia Terminated NCT00176566 Phase 2 Lozenge Intake
11 The Use of Platelet Rich Fibrin in Pulpal and Periodontal Regeneration in Mature Teeth Withdrawn NCT02477358 Phase 1, Phase 2
12 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Active, not recruiting NCT03059914 Phase 1
13 Clinical Trial of Zirconia and Metal Adhesive Bridges Unknown status NCT01347177 Not Applicable
14 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
15 Hypodontia and Ovarian Cancer Unknown status NCT01470235
16 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Unknown status NCT02397044
17 Clinical Study on Zirconia Bridges Unknown status NCT01835834 Not Applicable
18 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
19 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995 Not Applicable
20 Vertical Augmentation With Osteon at Dental Implant Placement Unknown status NCT01162629
21 Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants Unknown status NCT02937220 Not Applicable
22 Perception of Early Childhood Caries Unknown status NCT02899273
23 Stability of Implants With Different Surface Treatment: Randomized Clinical Trial Unknown status NCT01699568 Not Applicable
24 Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries Unknown status NCT02056262
25 OHQoL With Removable Partial Dentures; a Pilot Study Completed NCT01953991 Not Applicable
26 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420 Not Applicable
27 Sonographic Imaging of Oral and Dental Anatomical Structures (A Pilot Study) Completed NCT03657589
28 Radiographic and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement Completed NCT03302143 Not Applicable
29 Effect of Implant Thread Design on Implant Stability Quotient (ISQ) in Early Healing Period Completed NCT02701387 Not Applicable
30 Chewing Side Preference and Hemispheric Laterality in Healthy Adults Completed NCT03054246 Not Applicable
31 The Clinical Performance of Inlay Zirconia Bridges Completed NCT02995876 Not Applicable
32 Risk Factors for Implant Bone Loss in Patients With Diabetes Mellitus Completed NCT00933491
33 An Assessment of Bone Augmentation in Post-Extraction Sockets Completed NCT00641316 Not Applicable
34 Esthetic Outcomes of Immediately Placed Implants Receiving Immediate Provisionalization and Delayed Restoration Completed NCT01925339 Not Applicable
35 Longitudinal Efficacy of Dental Implants in Anterior Areas Completed NCT00641277
36 Bone Quality and Quantity Following Guided Bone Regeneration Prior to Dental Implant Placement Completed NCT01603693 Not Applicable
37 An Implant With an Acid-etched Fixture Surface and Internal-hex Collar May Achieve Greater Osseointegration. Completed NCT01641198 Not Applicable
38 Clinical Study of Oral Endosseous Titanium Implants in Edentulous Subjects Completed NCT00001211
39 Effects of Fixed and Removable Space Maintainers on Periodontal Health and DMFT/Dft Values Completed NCT03608345
40 Histological Comparison of Ridge Preservation Using Mineralized FDBA Alone Versus a Combined Mineralized-Demineralized Freeze Dried Bone Allograft Completed NCT01924390 Not Applicable
41 Evaluation of the ACE Dental Implant Completed NCT00641576
42 Electromyographic Estimation of Neuro-muscular Coordination of Masticatory Muscles in Patients Treated With Implants (D-2012-057) Completed NCT03415971 Not Applicable
43 Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study Completed NCT03614871
44 Oral Health and People With Systemic Sclerosis Completed NCT01817361
45 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718 Not Applicable
46 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311 Not Applicable
47 A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA Recruiting NCT03655990
48 REFRAME RPD Post-Market Clinical Study Recruiting NCT03198520 Not Applicable
49 Comparison Between Clear Aligners and Traditional Fixed Appliances in the Treatment of Four-premolar-extraction Cases Recruiting NCT03645356 Not Applicable
50 Survival of Endocrowns Made From Different Ceramics Recruiting NCT03542019 Not Applicable

Search NIH Clinical Center for Anodontia

Genetic Tests for Anodontia

Genetic tests related to Anodontia:

# Genetic test Affiliating Genes
1 Anodontia 29

Anatomical Context for Anodontia

MalaCards organs/tissues related to Anodontia:

41
Skin, Kidney, Liver, Bone

Publications for Anodontia

Articles related to Anodontia:

(show top 50) (show all 121)
# Title Authors Year
1
"Maxillary lateral incisor partial anodontia sequence": a clinical entity with epigenetic origin. ( 29364376 )
2017
2
DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia. ( 26759063 )
2016
3
Early functional, esthetic, and psychological rehabilitation of preschool child with nonsyndromic oligodontia and anodontia in mixed dentition stage through conservative systematic approach: A case report with 5-year follow-up. ( 27307674 )
2016
4
Dental management of Rothmund-Thomson syndrome with partial anodontia. ( 26032705 )
2015
5
PAX9 polymorphism and susceptibility to sporadic non-syndromic severe anodontia: a case-control study in southwest China. ( 23857653 )
2013
6
Prosthodontic management of hypohidrotic ectodermal dysplasia with anodontia: a case report in pediatric patient and review of literature. ( 23919206 )
2013
7
Prosthetic rehabilitation of a child suffering from hypohidrotic ectodermal dysplasia with complete anodontia. ( 25206157 )
2012
8
Total anodontia in patient with hypohidrotic ectodermal dysplasia. Report of rare case of Christ-Siemens Touraine syndrome. ( 21417166 )
2011
9
Prosthetic rehabilitation of a preschooler with induced anodontia - A clinical report. ( 22090765 )
2011
10
Ectodermal dysplasia with true anodontia. ( 22529591 )
2011
11
Ectodermal dysplasia with anodontia: a report of two cases. ( 20396456 )
2010
12
Prosthodontic rehabilitation of a patient with true partial anodontia - A case report. ( 23204727 )
2010
13
Congenital oligodontia of the deciduous teeth and anodontia of the permanent teeth in a cat. ( 18835802 )
2009
14
Congenital anodontia in ectodermal dysplasia. ( 19189682 )
2008
15
Prosthetic rehabilitation of an adolescent with hypohidrotic ectodermal dysplasia with partial anodontia: case report. ( 19008629 )
2008
16
Congenital hypotrichosis and partial anodontia in a crossbred beef calf. ( 17616058 )
2007
17
Hypohidrotic ectodermal dysplasia with true anodontia of the primary dentition. ( 18197325 )
2007
18
Prosthodontic treatment of hypohidrotic ectodermal dysplasia with complete anodontia: case report. ( 17216912 )
2007
19
Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case. ( 16891749 )
2006
20
Congenital hypotrichosis with anodontia in cattle: a genetic, clinical and histological analysis. ( 12464063 )
2002
21
Prosthodontic rehabilitation of a patient with partial anodontia: a clinical report. ( 12397238 )
2002
22
Ectodermal dysplasia with total anodontia: rehabilitation of a seven year old child. ( 12435010 )
2002
23
Clinical management of hypohidrotic ectodermal dysplasia with anodontia: case report. ( 12413164 )
2002
24
A rare non-syndrome case of concomitant multiple supernumerary teeth and partial anodontia. ( 11314218 )
2001
25
Oxygen, sulphide and nutrient uptake of the mangrove mud clam Anodontia edentula (Family: Lucinidae). ( 11763226 )
2001
26
Anodontia with hypohidrotic ectodermal dysplasia in a young female: a case report. ( 10730287 )
2000
27
Anodontia of permanent teeth (OMIM # 206780) and pegged/missing maxillary lateral incisors (OMIM # 150400) in the same family. ( 10710232 )
2000
28
Partial anodontia in a case of Waardenburg's syndrome. ( 10605569 )
1999
29
The use of colored elastomeric "O"s as a motivational instrument for patients with anodontia: report of case. ( 10431618 )
1999
30
Primary tuberculous liver abscess associated with progressive symmetric erythrokeratodermia, anodontia and ectodermal dysplasias. ( 9828554 )
1998
31
Implant-supported prosthesis in a child with hereditary mandibular anodontia: the use of ball attachments. ( 9558550 )
1998
32
Craniofacial changes following early prosthetic treatment in a case of hypohidrotic ectodermal dysplasia with complete anodontia. ( 9617452 )
1998
33
The use of magnets in the comprehensive treatment of congenital partial anodontia: a case report. ( 9477872 )
1997
34
Prosthetic rehabilitation of a child with induced anodontia. ( 8634197 )
1995
35
Oral rehabilitation of a patient with congenital partial anodontia using a rotational path removable partial denture: report of a case. ( 7568733 )
1995
36
Treating severe partial anodontia: a 10-year history of patient treatment. ( 7798481 )
1994
37
Longitudinal study of jaw growth and prosthetic management in a patient with ectodermal dysplasia and anodontia. ( 8329334 )
1993
38
Dentocraniofacial structure with complete anodontia of permanent teeth: report of case. ( 1629447 )
1992
39
Anodontia associated with hypohidrotic ectodermal dysplasia. ( 1344283 )
1992
40
Overdentures in partial anodontia: simple solutions for complex problems. ( 1860126 )
1991
41
Anodontia of the permanent dentition: fourteen years after initial diagnosis. ( 2319058 )
1990
42
Complete anodontia of the permanent dentition: case report. ( 2133936 )
1990
43
Prosthetic management of hypohydrotic ectodermal dysplasia with anodontia. Case report. ( 2346400 )
1990
44
Anodontia and jaw dysplasia syndrome: an isolated, idiopathic aberration. ( 2097249 )
1990
45
Anodontia as the sole clinical sign of the ectrodactyly-ectodermal dysplasia-cleft lip (EEC) syndrome. ( 2222925 )
1990
46
[Absence of permanent teeth buds in three generations of a family]. ( 2104354 )
1990
47
Unilateral linear basal cell nevus associated with diffuse osteoma cutis, unilateral anodontia, and abnormal bone mineralization. ( 2715453 )
1989
48
Partial anodontia: a case report. ( 2598201 )
1989
49
Congenital partial anodontia: prosthodontic considerations. ( 3250573 )
1988
50
Ectodermal dysplasia with partial anodontia: prosthetic treatment with implant fixed prosthesis. ( 3045169 )
1988

Variations for Anodontia

Expression for Anodontia

Search GEO for disease gene expression data for Anodontia.

Pathways for Anodontia

Pathways related to Anodontia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 AXIN2 MSX1
2 11.06 AXIN2 MSX1 PAX9
3 10.43 EDA EDARADD

GO Terms for Anodontia

Biological processes related to Anodontia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.55 AXIN2 EDA EDARADD MSX1 PAX9
2 positive regulation of canonical Wnt signaling pathway GO:0090263 9.4 AXIN2 EDA
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.37 EDA EDARADD
4 odontogenesis of dentin-containing tooth GO:0042475 9.32 EDA MSX1
5 face morphogenesis GO:0060325 9.26 MSX1 PAX9
6 regulation of odontogenesis GO:0042481 8.96 MSX1 PAX9
7 odontogenesis GO:0042476 8.8 AXIN2 MSX1 PAX9

Sources for Anodontia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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