MCID: AND017
MIFTS: 24

Anodontia of Permanent Dentition

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Anodontia of Permanent Dentition

MalaCards integrated aliases for Anodontia of Permanent Dentition:

Name: Anodontia of Permanent Dentition 56
Teeth, Permanent, Absence of 56
Anodontia 58

Characteristics:

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
anodontia of permanent dentition:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare odontological diseases


External Ids:

OMIM 56 206780
MESH via Orphanet 44 D000848
ICD10 via Orphanet 33 K00.0
UMLS via Orphanet 72 C0399352
Orphanet 58 ORPHA99797
MedGen 41 C1290511
SNOMED-CT via HPO 68 16958000 258211005 26624006

Summaries for Anodontia of Permanent Dentition

MalaCards based summary : Anodontia of Permanent Dentition, also known as teeth, permanent, absence of, is related to brachymetapody-anodontia-hypotrichosis-albinoidism and epidermolysis bullosa simplex with anodontia/hypodontia. The drugs Ibuprofen and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and kidney, and related phenotype is anodontia.

More information from OMIM: 206780

Related Diseases for Anodontia of Permanent Dentition

Diseases related to Anodontia of Permanent Dentition via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 brachymetapody-anodontia-hypotrichosis-albinoidism 12.3
2 epidermolysis bullosa simplex with anodontia/hypodontia 12.2
3 tooth agenesis 12.2
4 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 11.7
5 anodontia 11.7
6 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.6
7 tooth agenesis, selective, 1 11.5
8 ectodermal dysplasia 1, hypohidrotic, x-linked 11.5
9 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 11.2
10 osteoglophonic dysplasia 11.2
11 cleft lip/palate-ectodermal dysplasia syndrome 11.2
12 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 11.2
13 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 11.2
14 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 11.2
15 ectodermal dysplasia 10.9
16 hypotrichosis 10.6
17 anhidrosis 10.5
18 alopecia 10.4
19 teeth, supernumerary 10.3
20 hair whorl 10.3
21 gapo syndrome 10.3
22 3-methylglutaconic aciduria, type iii 10.3
23 cleft palate, isolated 10.2
24 autosomal recessive disease 10.2
25 keratosis 10.2
26 cleft lip 10.2
27 hidrotic ectodermal dysplasia 2 10.2
28 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.0
29 tooth agenesis, selective, 4 10.0
30 split-hand/foot malformation 1 10.0
31 epidermolysis bullosa, late-onset localized junctional, with mental retardation 10.0
32 nephronophthisis 1 10.0
33 rothmund-thomson syndrome, type 2 10.0
34 incontinentia pigmenti 10.0
35 tooth size 10.0
36 brittle bone disorder 10.0
37 patau syndrome 10.0
38 diarrhea 10.0
39 ankylosis 10.0
40 epidermolysis bullosa 10.0
41 dentinogenesis imperfecta 10.0
42 epidermolysis bullosa simplex 10.0
43 waardenburg's syndrome 10.0
44 periodontosis 10.0
45 48,xyyy 10.0
46 chromosomal triplication 10.0
47 medullary sponge kidney 10.0
48 isolated split hand-split foot malformation 10.0

Graphical network of the top 20 diseases related to Anodontia of Permanent Dentition:



Diseases related to Anodontia of Permanent Dentition

Symptoms & Phenotypes for Anodontia of Permanent Dentition

Human phenotypes related to Anodontia of Permanent Dentition:

31
# Description HPO Frequency HPO Source Accession
1 anodontia 31 HP:0000674

Symptoms via clinical synopsis from OMIM:

56
Teeth:
anodontia, permanent dentition
primary dentition unaffected
pegged or missing maxillary lateral incisors in heterozygotes

Clinical features from OMIM:

206780

Drugs & Therapeutics for Anodontia of Permanent Dentition

Drugs for Anodontia of Permanent Dentition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3 Acetaminophen, hydrocodone drug combination Phase 4
4 Pharmaceutical Solutions Phase 4
5
Cobalt Approved, Experimental 7440-48-4 104729
6
Dopamine Approved 51-61-6, 62-31-7 681
7
Methamphetamine Approved, Illicit 537-46-2 10836
8
Lithium carbonate Approved 554-13-2
9
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
10
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
11 Anesthetics
12 Anti-Bacterial Agents
13 Antibiotics, Antitubercular
14 Neurotransmitter Agents
15 Sympathomimetics
16 Dopamine Agents
17 Dopamine Uptake Inhibitors
18 Central Nervous System Stimulants
19 Autonomic Agents
20 Adrenergic Agents
21 Tranquilizing Agents
22 Psychotropic Drugs
23 Antimanic Agents
24 Central Nervous System Depressants
25 Antidepressive Agents
26 Keratolytic Agents
27 Antifungal Agents
28 Dermatologic Agents
29 Buchu
30 Anti-Infective Agents

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 The Effectiveness of the Cytoplast Technique in Preventing Bone Loss Around Immediate Implant Placement in the Esthetic Zone. A Randomized Clinical Trial. Completed NCT01628367 Phase 4 Medications
2 A Phase III, Randomized, Controlled Clinical Trial of Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
3 Evaluation of Retention of Metal Reinforced Polyamide Denture Base Compared to Conventional Heat Cured Acrylic Resin Denture Base in Complete Mandibular Denture Unknown status NCT03385746
4 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
5 Clinical Study on Zirconia Bridges Unknown status NCT01835834
6 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
7 Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer. Unknown status NCT01470235
8 Immediate and Early Loading of Hydrothermally Treated, Hydroxyapatite-Coated Dental Implants:a Controlled Randomized Prospective Clinical Study Unknown status NCT02397044
9 A Single-centre Randomised Controlled Clinical Trial of Zirconia-based Versus Metal-based Adhesive Bridges for Replacing 2 Missing Teeth or Less in Adults. Unknown status NCT01347177
10 A Comparison of Zirconia CAD/CAM and Conventionally Fabricated Single Implant Abutments and Restorations in the Esthetic Zone: a Randomized Controlled Clinical Trial. Unknown status NCT01229995
11 A Pilot Study Investigating Oral Health Related Quality of Life Improvements in Removable Partial Denture Treatments for the Replacement of Missing Teeth Completed NCT01953991
12 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420
13 A Comparative, Randomized, Prospective, Clinical Study to Evaluate the Facial Bone and Esthetic Outcome of Buccal Augmentation Bone Grafting Techniques in Early (Type 2) Implant Placement Completed NCT03302143
14 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors: A Cross Sectional Study Recruiting NCT03445026
15 Effect of Neurectomy of Nasopalatine Nerve on Sensation of Anterior Palate in Patient Undergoing Rehabilitation of Atrophic Anterior Maxillary Ridge With Dental Implant Recruiting NCT04153851
16 Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model Recruiting NCT03877419
17 A Prospective, Single-Centre, Post-Market Study to Evaluate the Use of Polyetheretherketone (PEEK) Full-Arch Implant-Supported Prostheses in the Edentulous Jaw Recruiting NCT03655990
18 Evaluation of the Efficacy of Clear Aligners in the Correction of Severe Dental Crowding Cases Combined With Premolar Extraction Versus Vestibular Fixed Orthodontic Appliances: A Randomized Clinical Controlled Trial Recruiting NCT03645356
19 Autotransplantation of Teeth With Advanced or Completed Root Development With Intraoperative Extra-corporal Apicoectomy Recruiting NCT04041518
20 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718
21 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
22 REFRAME RPD Post-Market Clinical Study Active, not recruiting NCT03198520
23 Correlation Study Between Socio-economical Deprivation and Oral Health in in French Children of 9 Years of Age in 2017. A Nationwide Database Retrospective Observational Cohort Study Active, not recruiting NCT03817437
24 A Histomorphometric Analysis of New Bone Formation Following Sinus Augmentation Using Two Different Bone Graft Materials. A Pilot Study in Humans. Active, not recruiting NCT03059914
25 Clinical Evaluation of Chairside Computer Assisted Design/Computer Assisted Machining (CAD/CAM) Lithium Disilicate Fixed Partial Dentures (FPD) Active, not recruiting NCT03036566
26 The Effect of Platform-Matching Versus Platform-Switching Using Standard Internal Versus Tapered Internal Plus Dental Implants on Peri-implant Hard and Soft Tissue Healing Active, not recruiting NCT02536716
27 A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth Official Title: Enrolling by invitation NCT02793037
28 No-preparation Resin Bonded Bridges for the Replacement of Single Missing Teeth Not yet recruiting NCT03029637
29 Evaluation of the Effect of Slopped Shoulder Implant Neck Versus Conventional Implant Neck Design on the Crestal Bone Level in the Maxilla: Randomized Clinical Trial (RCT) Not yet recruiting NCT03614442
30 Clinical Assessment Of Inlay Retained Bridge Designs (Tub Shaped And Inlay Shaped) In Missing Posterior Teeth Cases. Not yet recruiting NCT03715842
31 Observational, Case-Series Study Evaluation of Bone Width and Dental Implant Stability When Using the Densah Bur™ Bone Compaction Process to Prepare Dental Implant Sites Withdrawn NCT02502058

Search NIH Clinical Center for Anodontia of Permanent Dentition

Genetic Tests for Anodontia of Permanent Dentition

Anatomical Context for Anodontia of Permanent Dentition

MalaCards organs/tissues related to Anodontia of Permanent Dentition:

40
Bone, Salivary Gland, Kidney

Publications for Anodontia of Permanent Dentition

Articles related to Anodontia of Permanent Dentition:

# Title Authors PMID Year
1
WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. 56
19559398 2009
2
Anodontia of permanent teeth (OMIM # 206780) and pegged/missing maxillary lateral incisors (OMIM # 150400) in the same family. 56
10710232 2000
3
Agenesis of succedaneous teeth: an expression of the homozygous state of the gene for the pegged or missing maxillary lateral incisor trait. 56
3812593 1987
4
Complete absence of the permanent dentition: an autosomal recessive disorder. 56
7011028 1980
5
Complete absence of the permanent dentition: an autosomal recessive disorder. 56
7395912 1980
6
Anodontia of the permanent dentition: report of case. 56
319130 1977
7
Case report of complete anodontia of the permanent teeth. 56
20272163 1947
8
Determination of vertical dimension in prosthodontic rehabilitation of a growing patient with severe oligodontia. 61
25793956 2015

Variations for Anodontia of Permanent Dentition

Expression for Anodontia of Permanent Dentition

Search GEO for disease gene expression data for Anodontia of Permanent Dentition.

Pathways for Anodontia of Permanent Dentition

GO Terms for Anodontia of Permanent Dentition

Sources for Anodontia of Permanent Dentition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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