Anodontia of Permanent Dentition

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Anodontia of Permanent Dentition

MalaCards integrated aliases for Anodontia of Permanent Dentition:

Name: Anodontia of Permanent Dentition 57
Teeth, Permanent, Absence of 57
Absent Permanent Teeth 6
Anodontia 58



57 (Updated 05-Mar-2021)
autosomal recessive


anodontia of permanent dentition:
Inheritance autosomal recessive inheritance


Orphanet: 58  
Rare odontological diseases

External Ids:

OMIM® 57 206780
MESH via Orphanet 45 D000848
ICD10 via Orphanet 33 K00.0
UMLS via Orphanet 72 C0399352
Orphanet 58 ORPHA99797
MedGen 41 C1290511
SNOMED-CT via HPO 68 16958000 258211005 26624006

Summaries for Anodontia of Permanent Dentition

MalaCards based summary : Anodontia of Permanent Dentition, also known as teeth, permanent, absence of, is related to anodontia and brachymetapody-anodontia-hypotrichosis-albinoidism. An important gene associated with Anodontia of Permanent Dentition is SBDS (SBDS Ribosome Maturation Factor). The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotype is anodontia.

More information from OMIM: 206780

Related Diseases for Anodontia of Permanent Dentition

Diseases related to Anodontia of Permanent Dentition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 anodontia 11.4
2 brachymetapody-anodontia-hypotrichosis-albinoidism 11.2
3 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 11.1
4 epidermolysis bullosa simplex with anodontia/hypodontia 11.1
5 tooth agenesis 11.1
6 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.0
7 tooth agenesis, selective, 1 10.9
8 ectodermal dysplasia 1, hypohidrotic, x-linked 10.9
9 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 10.9
10 osteoglophonic dysplasia 10.9
11 cleft lip/palate-ectodermal dysplasia syndrome 10.9
12 ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome 10.9
13 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 10.9
14 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 10.9
15 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 10.9
16 ectodermal dysplasia 10.7
17 hypotrichosis 10.4
18 anhidrosis 10.3
19 alopecia 10.2
20 teeth, supernumerary 10.1
21 hair whorl 10.1
22 gapo syndrome 10.1
23 3-methylglutaconic aciduria, type iii 10.1
24 johanson-blizzard syndrome 10.0
25 branchiootic syndrome 1 10.0
26 hypothyroidism 10.0
27 dwarfism 10.0
28 cleft palate, isolated 10.0
29 tooth size 10.0
30 autosomal recessive disease 10.0
31 keratosis 10.0
32 cleft lip 10.0
33 hidrotic ectodermal dysplasia 2 10.0
34 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 9.8
35 tooth agenesis, selective, 4 9.8
36 split-hand/foot malformation 1 9.8
37 epidermolysis bullosa, late-onset localized junctional, with mental retardation 9.8
38 nephronophthisis 1 9.8
39 rothmund-thomson syndrome, type 2 9.8
40 incontinentia pigmenti 9.8
41 brittle bone disorder 9.8
42 patau syndrome 9.8
43 ankylosis 9.8
44 epidermolysis bullosa 9.8
45 dentinogenesis imperfecta 9.8
46 epidermolysis bullosa simplex 9.8
47 waardenburg's syndrome 9.8
48 periodontosis 9.8
49 chromosomal triplication 9.8
50 medullary sponge kidney 9.8

Graphical network of the top 20 diseases related to Anodontia of Permanent Dentition:

Diseases related to Anodontia of Permanent Dentition

Symptoms & Phenotypes for Anodontia of Permanent Dentition

Human phenotypes related to Anodontia of Permanent Dentition:

# Description HPO Frequency HPO Source Accession
1 anodontia 31 HP:0000674

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
anodontia, permanent dentition
primary dentition unaffected
pegged or missing maxillary lateral incisors in heterozygotes

Clinical features from OMIM®:

206780 (Updated 05-Mar-2021)

Drugs & Therapeutics for Anodontia of Permanent Dentition

Drugs for Anodontia of Permanent Dentition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Ibuprofen Approved Phase 4 15687-27-1 3672
3 Pharmaceutical Solutions Phase 4
4 Acetaminophen, hydrocodone drug combination Phase 4
Cobalt Approved, Experimental 7440-48-4 104729
Denosumab Approved 615258-40-7
Lithium carbonate Approved 554-13-2
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
9 Antibiotics, Antitubercular
10 Anesthetics
11 Anti-Bacterial Agents
12 Diphosphonates
13 Antidepressive Agents
14 Psychotropic Drugs

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 The Effectiveness of the Cytoplast Technique in Preventing Bone Loss Around Immediate Implant Placement in the Esthetic Zone. A Randomized Clinical Trial. Completed NCT01628367 Phase 4 Medications
2 A Phase III, Randomized, Controlled Clinical Trial of Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
3 Evaluation of Retention of Metal Reinforced Polyamide Denture Base Compared to Conventional Heat Cured Acrylic Resin Denture Base in Complete Mandibular Denture Unknown status NCT03385746
4 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
5 A Single-centre Randomised Controlled Clinical Trial of Zirconia-based Versus Metal-based Adhesive Bridges for Replacing 2 Missing Teeth or Less in Adults. Unknown status NCT01347177
6 Clinical Study on Zirconia Bridges Unknown status NCT01835834
7 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors: A Cross Sectional Study Unknown status NCT03445026
8 Hypodontia and Ovarian Cancer - the Connection Between Dental Agenesis and Epithelial Cancers, Especially Ovarian Cancer. Unknown status NCT01470235
9 A Comparison of Zirconia CAD/CAM and Conventionally Fabricated Single Implant Abutments and Restorations in the Esthetic Zone: a Randomized Controlled Clinical Trial. Unknown status NCT01229995
10 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
11 Immediate and Early Loading of Hydrothermally Treated, Hydroxyapatite-Coated Dental Implants:a Controlled Randomized Prospective Clinical Study Unknown status NCT02397044
12 Evaluation of the Effect of Slopped Shoulder Implant Neck Versus Conventional Implant Neck Design on the Crestal Bone Level in the Maxilla: Randomized Clinical Trial (RCT) Unknown status NCT03614442
13 Clinical Assessment Of Inlay Retained Bridge Designs (Tub Shaped And Inlay Shaped) In Missing Posterior Teeth Cases. Unknown status NCT03715842
14 A Pilot Study Investigating Oral Health Related Quality of Life Improvements in Removable Partial Denture Treatments for the Replacement of Missing Teeth Completed NCT01953991
15 A Comparative, Randomized, Prospective, Clinical Study to Evaluate the Facial Bone and Esthetic Outcome of Buccal Augmentation Bone Grafting Techniques in Early (Type 2) Implant Placement Completed NCT03302143
16 Correlation Study Between Socio-economical Deprivation and Oral Health in in French Children of 9 Years of Age in 2017. A Nationwide Database Retrospective Observational Cohort Study Completed NCT03817437
17 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420
18 A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth Official Title: Completed NCT02793037
19 The Effect of Platform-Matching Versus Platform-Switching Using Standard Internal Versus Tapered Internal Plus Dental Implants on Peri-implant Hard and Soft Tissue Healing Completed NCT02536716
20 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Completed NCT02239718
21 A Histomorphometric Analysis of New Bone Formation Following Sinus Augmentation Using Two Different Bone Graft Materials. A Pilot Study in Humans. Completed NCT03059914
22 Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model Completed NCT03877419
23 REFRAME RPD Post-Market Clinical Study Completed NCT03198520
24 Retention and Durability of the Anterior Zirconia Wing Bridge Recruiting NCT04378140
25 Autotransplantation of Teeth With Advanced or Completed Root Development With Intraoperative Extra-corporal Apicoectomy Recruiting NCT04041518
26 Effect of Neurectomy of Nasopalatine Nerve on Sensation of Anterior Palate in Patient Undergoing Rehabilitation of Atrophic Anterior Maxillary Ridge With Dental Implant Recruiting NCT04153851
27 Dental Rehabilitation of Cancer Patients With Bone Metastases on High Dose Antiresorptives Recruiting NCT04741906
28 Evaluation Of Innovative 3D Printed Space Maintainer Versus Conventional One Recruiting NCT04221243
29 A Prospective, Single-Centre, Post-Market Study to Evaluate the Use of Polyetheretherketone (PEEK) Full-Arch Implant-Supported Prostheses in the Edentulous Jaw Recruiting NCT03655990
30 Evaluation of the Efficacy of Clear Aligners in the Correction of Severe Dental Crowding Cases Combined With Premolar Extraction Versus Vestibular Fixed Orthodontic Appliances: A Randomized Clinical Controlled Trial Recruiting NCT03645356
31 Clinical Evaluation of Chairside Computer Assisted Design/Computer Assisted Machining (CAD/CAM) Lithium Disilicate Fixed Partial Dentures (FPD) Active, not recruiting NCT03036566
32 The Use of Bio-Oss Collagen for Sinus Augmentation Using the Transcrestal Approach. Not yet recruiting NCT04581304
33 Randomized Controlled Clinical Trial of Two-unit Cantilever Implant Prostheses Made of Monolithic Zirconia on Titanium Base Abutments or Porcelain-fused to Metal on Gold Abutments Not yet recruiting NCT04713800
34 No-preparation Resin Bonded Bridges for the Replacement of Single Missing Teeth Not yet recruiting NCT03029637
35 Alveolar Ridge Expansion by Osseodensification and Its Impact on Implant Survival and Success: A Case Series Not yet recruiting NCT04741594
36 X-space Implants in Post-extraction Sites. A CBCT Randomized Clinical Trial Not yet recruiting NCT04492111
37 Observational, Case-Series Study Evaluation of Bone Width and Dental Implant Stability When Using the Densah Bur™ Bone Compaction Process to Prepare Dental Implant Sites Withdrawn NCT02502058

Search NIH Clinical Center for Anodontia of Permanent Dentition

Genetic Tests for Anodontia of Permanent Dentition

Anatomical Context for Anodontia of Permanent Dentition

MalaCards organs/tissues related to Anodontia of Permanent Dentition:


Publications for Anodontia of Permanent Dentition

Articles related to Anodontia of Permanent Dentition:

# Title Authors PMID Year
WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. 57
19559398 2009
Anodontia of permanent teeth (OMIM # 206780) and pegged/missing maxillary lateral incisors (OMIM # 150400) in the same family. 57
10710232 2000
Agenesis of succedaneous teeth: an expression of the homozygous state of the gene for the pegged or missing maxillary lateral incisor trait. 57
3812593 1987
Complete absence of the permanent dentition: an autosomal recessive disorder. 57
7011028 1980
Complete absence of the permanent dentition: an autosomal recessive disorder. 57
7395912 1980
Anodontia of the permanent dentition: report of case. 57
319130 1977
Case report of complete anodontia of the permanent teeth. 57
20272163 1947
Determination of vertical dimension in prosthodontic rehabilitation of a growing patient with severe oligodontia. 61
25793956 2015

Variations for Anodontia of Permanent Dentition

ClinVar genetic disease variations for Anodontia of Permanent Dentition:

# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SBDS NM_016038.4(SBDS):c.258+2T>C SNV Pathogenic 3196 rs113993993 7:66459197-66459197 7:66994210-66994210
2 SBDS NM_016038.4(SBDS):c.184A>T (p.Lys62Ter) SNV Likely pathogenic 449095 rs120074160 7:66459273-66459273 7:66994286-66994286

Expression for Anodontia of Permanent Dentition

Search GEO for disease gene expression data for Anodontia of Permanent Dentition.

Pathways for Anodontia of Permanent Dentition

GO Terms for Anodontia of Permanent Dentition

Sources for Anodontia of Permanent Dentition

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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