MCID: AND017
MIFTS: 23

Anodontia of Permanent Dentition

Categories: Oral diseases, Rare diseases

Aliases & Classifications for Anodontia of Permanent Dentition

MalaCards integrated aliases for Anodontia of Permanent Dentition:

Name: Anodontia of Permanent Dentition 58
Teeth, Permanent, Absence of 58
Anodontia 60

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
anodontia of permanent dentition:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 60  
Rare odontological diseases


External Ids:

OMIM 58 206780
MESH via Orphanet 46 D000848
ICD10 via Orphanet 35 K00.0
UMLS via Orphanet 75 C0399352
Orphanet 60 ORPHA99797
MedGen 43 C1290511
SNOMED-CT via HPO 70 16958000 258211005 26624006

Summaries for Anodontia of Permanent Dentition

MalaCards based summary : Anodontia of Permanent Dentition, also known as teeth, permanent, absence of, is related to brachymetapody-anodontia-hypotrichosis-albinoidism and epidermolysis bullosa simplex with anodontia/hypodontia. The drugs Amoxicillin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include bone and kidney, and related phenotype is anodontia.

Description from OMIM: 206780

Related Diseases for Anodontia of Permanent Dentition

Diseases related to Anodontia of Permanent Dentition via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 brachymetapody-anodontia-hypotrichosis-albinoidism 12.2
2 epidermolysis bullosa simplex with anodontia/hypodontia 12.1
3 tooth agenesis 12.1
4 anodontia 11.6
5 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 11.5
6 late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome 11.4
7 ectodermal dysplasia 1, hypohidrotic, x-linked 11.4
8 tooth agenesis, selective, 1 11.1
9 ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant 11.1
10 ectodermal dysplasia 11a, hypohidrotic/hair/tooth type, autosomal dominant 11.1
11 ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive 11.1
12 ectodermal dysplasia 12, hypohidrotic/hair/tooth/nail type 11.1
13 zlotogora syndrome 11.1
14 ectodermal dysplasia 10.7
15 hypotrichosis 10.3
16 teeth, supernumerary 10.1
17 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.0
18 split-hand/foot malformation 1 10.0
19 gapo syndrome 10.0
20 3-methylglutaconic aciduria, type iii 10.0
21 rothmund-thomson syndrome 10.0
22 incontinentia pigmenti 10.0
23 erythrokeratodermia variabilis et progressiva 5 10.0
24 alopecia 10.0
25 anhidrosis 10.0
26 patau syndrome 10.0
27 ankylosis 10.0
28 epidermolysis bullosa 10.0
29 epidermolysis bullosa simplex 10.0
30 waardenburg's syndrome 10.0
31 cleft lip 10.0
32 medullary sponge kidney 10.0
33 isolated split hand-split foot malformation 10.0

Graphical network of the top 20 diseases related to Anodontia of Permanent Dentition:



Diseases related to Anodontia of Permanent Dentition

Symptoms & Phenotypes for Anodontia of Permanent Dentition

Human phenotypes related to Anodontia of Permanent Dentition:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anodontia 60 33 Very frequent (99-80%) HP:0000674

Symptoms via clinical synopsis from OMIM:

58
Teeth:
anodontia, permanent dentition
primary dentition unaffected
pegged or missing maxillary lateral incisors in heterozygotes

Clinical features from OMIM:

206780

Drugs & Therapeutics for Anodontia of Permanent Dentition

Drugs for Anodontia of Permanent Dentition (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3 Pharmaceutical Solutions Phase 4
4 Acetaminophen, hydrocodone drug combination Phase 4
5
Cobalt Approved, Experimental Not Applicable 7440-48-4 104729
6
Lithium carbonate Approved Not Applicable 554-13-2
7
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
8
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
9 Tranquilizing Agents Not Applicable
10 Antidepressive Agents Not Applicable
11 Central Nervous System Depressants Not Applicable
12 Antimanic Agents Not Applicable
13 Psychotropic Drugs Not Applicable
14 Anti-Infective Agents Not Applicable
15 Buchu Not Applicable
16 Keratolytic Agents Not Applicable
17 Antifungal Agents Not Applicable
18 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Guided Bone Regeneration Around Immediate Implants Completed NCT01628367 Phase 4 Medications
2 Lateral Ridge Augmentation Using Autogenous Bone Blocks or Xenogenic Bone Block Grafts Loaded With Recombinant Human Bone Morphogenic Protein 2 Active, not recruiting NCT01541345 Phase 3 InductOs
3 A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials. Active, not recruiting NCT03059914 Phase 1
4 Linkage and Identification of (a) Candidate Gene(s) for Tooth Disorders Unknown status NCT00026026
5 "Prospective Evaluation of Immediate & Early Loading of Zimmer Hydroxyapatite Coated Dental Implants" Unknown status NCT02397044
6 Clinical Study on Zirconia Bridges Unknown status NCT01835834 Not Applicable
7 Clinical Trial of Zirconia and Metal Adhesive Bridges Unknown status NCT01347177 Not Applicable
8 Randomized Controlled Clinical Trial of CAD/CAM and Conventionally Fabricated Singl Implant Abutments. Unknown status NCT01229995 Not Applicable
9 Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant Unknown status NCT01510470
10 Hypodontia and Ovarian Cancer Unknown status NCT01470235
11 Platform Switching vs Regular Platform Implants. One Year Results From a RCT Completed NCT02123420 Not Applicable
12 OHQoL With Removable Partial Dentures; a Pilot Study Completed NCT01953991 Not Applicable
13 Radiographic and the Esthetic Outcome of Two Different Bone Grafting Techniques in Early Implant Placement Completed NCT03302143 Not Applicable
14 Frequency of Hypodontia After Chemotherapy in Childhood Cancer Survivors Study Recruiting NCT03445026
15 A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA Recruiting NCT03655990
16 Novel Use of 2-unit Cantilever Resin-bonded Bridges for Replacing Missing Molar Teeth - a Randomized Clinical Trial Recruiting NCT02239718 Not Applicable
17 REFRAME RPD Post-Market Clinical Study Recruiting NCT03198520 Not Applicable
18 One-Tooth One-Time (1T1T) A Straightforward Approach to Replace Missing Teeth in the Posterior Region: a Case Series Recruiting NCT02898311 Not Applicable
19 Comparison Between Clear Aligners and Traditional Fixed Appliances in the Treatment of Four-premolar-extraction Cases Recruiting NCT03645356 Not Applicable
20 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
21 Lithium Disilicate (CAD/CAM) Fixed Partial Dentures (FPD) Clinical Study Active, not recruiting NCT03036566 Not Applicable
22 The Effect of Platform-Matching Versus Platform-Switching Dental Implants on Peri-implant Hard and Soft Tissue Healing Active, not recruiting NCT02536716 Not Applicable
23 Correlation Study Between Socio-economical Deprivation and Oral Health in Children of 9 Years of Age Active, not recruiting NCT03817437
24 A Proof of Concept for All-ceramic Zirconia Resin Bonded Bridges for Canine, Premolar and Short Span Posterior Teeth Enrolling by invitation NCT02793037 Not Applicable
25 Retention of Metal Reinforced Polyamide Denture Base and Heat Cured Acrylic Resin Denture Base in Complete Mandibular Denture Not yet recruiting NCT03385746 Not Applicable
26 Comparison of Different Drilling Speed to Classify Bone Quality by Tactile Sensation on a Saw Bone Model Not yet recruiting NCT03877419
27 Clinical Assessment Of Inlay Retained Bridge Designs (Tub Shaped And Inlay Shaped) In Missing Posterior Teeth Cases. Not yet recruiting NCT03715842 Not Applicable
28 Effect of Slopped Shoulder Implant Neck vs Conventional Implant Neck Design on Crestal Bone Level in the Maxilla Not yet recruiting NCT03614442 Not Applicable
29 No-preparation Resin Bonded Bridges for the Replacement of Single Missing Teeth Not yet recruiting NCT03029637 Not Applicable
30 Dental Implant Stability When Using the Densah Bur™ Bone Compaction Process to Prepare Dental Implant Sites Withdrawn NCT02502058

Search NIH Clinical Center for Anodontia of Permanent Dentition

Genetic Tests for Anodontia of Permanent Dentition

Anatomical Context for Anodontia of Permanent Dentition

MalaCards organs/tissues related to Anodontia of Permanent Dentition:

42
Bone, Kidney

Publications for Anodontia of Permanent Dentition

Variations for Anodontia of Permanent Dentition

Expression for Anodontia of Permanent Dentition

Search GEO for disease gene expression data for Anodontia of Permanent Dentition.

Pathways for Anodontia of Permanent Dentition

GO Terms for Anodontia of Permanent Dentition

Sources for Anodontia of Permanent Dentition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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