MCID: ANM031
MIFTS: 26

Anomalous Left Coronary Artery from the Pulmonary Artery

Categories: Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Anomalous Left Coronary Artery from the Pulmonary Artery

MalaCards integrated aliases for Anomalous Left Coronary Artery from the Pulmonary Artery:

Name: Anomalous Left Coronary Artery from the Pulmonary Artery 12 15
Bland White Garland Syndrome 44 70
Bland-White-Garland Syndrome 12
White-Garland Syndrome 12
Alcapa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060562
MeSH 44 D063748
UMLS 70 C1735886

Summaries for Anomalous Left Coronary Artery from the Pulmonary Artery

Disease Ontology : 12 A coronary artery anomaly in which the left coronary artery (LCA) branches off the pulmonary artery instead of the aortic sinus.

MalaCards based summary : Anomalous Left Coronary Artery from the Pulmonary Artery, also known as bland white garland syndrome, is related to heart septal defect and left bundle branch hemiblock. An important gene associated with Anomalous Left Coronary Artery from the Pulmonary Artery is GJA1 (Gap Junction Protein Alpha 1). Affiliated tissues include heart and brain, and related phenotypes are cardiovascular system and muscle

Related Diseases for Anomalous Left Coronary Artery from the Pulmonary Artery

Diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 heart septal defect 31.1 TBX18 GJA1
2 left bundle branch hemiblock 30.4 PKP2 NPPB
3 right bundle branch block 30.3 PKP2 NPPB
4 tetralogy of fallot 30.3 TBX18 NPPB GJA1
5 dilated cardiomyopathy 29.9 PKP2 NPPB LRRC10 GJA1 GATAD1
6 atrial heart septal defect 29.7 TBX18 NPPB GJA1
7 lipoprotein quantitative trait locus 29.7 TBX18 PKP2 NPPB GJA1 BMPER
8 mitral valve insufficiency 11.0
9 congestive heart failure 10.7
10 cardiac conduction defect 10.7
11 cardiac arrest 10.6
12 ventricular septal defect 10.5
13 aortopulmonary window 10.5
14 atrial standstill 1 10.4
15 endocardial fibroelastosis 10.4
16 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
17 ventricular fibrillation, paroxysmal familial, 1 10.4
18 patent ductus arteriosus 1 10.4
19 anterolateral myocardial infarction 10.4
20 progressive familial heart block, type ia 10.3
21 coronary aneurysm 10.3
22 noonan syndrome 1 10.3
23 pulmonary hypertension, primary, 1 10.3
24 orthostatic intolerance 10.3
25 peripartum cardiomyopathy 10.3
26 infective endocarditis 10.3
27 endocarditis 10.3
28 respiratory failure 10.3
29 heart disease 10.3
30 hypertrophic cardiomyopathy 10.3
31 bronchopneumonia 10.3
32 patent foramen ovale 10.3
33 mitral valve stenosis 10.3
34 myocarditis 10.3
35 hypoplastic left heart syndrome 10.3
36 coronary artery aneurysm 10.3
37 pseudo-turner syndrome 10.3
38 pulmonary venous return anomaly 10.3
39 single ventricular heart 10.3
40 aneurysm 10.3
41 fainting 10.3
42 syncope 10.3
43 progressive familial heart block, type ib 10.2
44 myocardial infarction 10.2
45 aortic dissection 10.2
46 lateral myocardial infarction 10.2
47 aorta-pulmonary artery fistula 10.2
48 mitral valve prolapse, familial, x-linked 10.2
49 posttransplant acute limbic encephalitis 10.2
50 sinoatrial node disease 10.2 TBX18 GJA1

Graphical network of the top 20 diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery:



Diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery

Symptoms & Phenotypes for Anomalous Left Coronary Artery from the Pulmonary Artery

MGI Mouse Phenotypes related to Anomalous Left Coronary Artery from the Pulmonary Artery:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 BMPER DNAH6 GJA1 LRRC10 ODAD3 PKP2
2 muscle MP:0005369 9.02 GJA1 LRRC10 PKP2 SCX TBX18

Drugs & Therapeutics for Anomalous Left Coronary Artery from the Pulmonary Artery

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Resynchronization of Left Ventricular Contraction After Re-implantation of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA) Evaluated by Tissue Doppler Imaging Terminated NCT00268112

Search NIH Clinical Center for Anomalous Left Coronary Artery from the Pulmonary Artery

Cochrane evidence based reviews: bland white garland syndrome

Genetic Tests for Anomalous Left Coronary Artery from the Pulmonary Artery

Anatomical Context for Anomalous Left Coronary Artery from the Pulmonary Artery

MalaCards organs/tissues related to Anomalous Left Coronary Artery from the Pulmonary Artery:

40
Heart, Brain

Publications for Anomalous Left Coronary Artery from the Pulmonary Artery

Articles related to Anomalous Left Coronary Artery from the Pulmonary Artery:

(show top 50) (show all 381)
# Title Authors PMID Year
1
Characteristics and Surgical Outcomes of Patients With Late Presentation of Anomalous Left Coronary Artery From the Pulmonary Artery: A Multicenter Study. 61
32858217 2021
2
Impact of Reverse Left Ventricular Remodeling on Outcomes of Patients with Anomalous Left Coronary Artery from the Pulmonary Artery after Surgical Correction. 61
33394115 2021
3
Anomalous left coronary artery from the pulmonary artery repair outcomes: Preoperative mitral regurgitation persists in the follow-up. 61
33331064 2021
4
Unexplained near-drowning can reveal ALCAPA in children. 61
33495076 2021
5
Current Strategies for the Management of Anomalous Origin of Coronary Arteries from the Pulmonary Artery. 61
33635248 2021
6
Anomalous left coronary artery from the pulmonary artery: An unusual cause of cardiac arrest. 61
33279451 2020
7
Intermediate Outcomes After Repair of Anomalous Left Coronary Artery From the Pulmonary Artery. 61
32961142 2020
8
Anomalous left coronary artery from the pulmonary artery: modified extra-anatomic reimplantation. 61
32944745 2020
9
Intravascular ultrasound use for stent optimization during percutaneous coronary intervention in a toddler with post-surgical stenosis after coronary reimplantation for ALCAPA. 61
32774525 2020
10
Transthoracic echocardiography features of adult-type anomalous left coronary artery from the pulmonary artery before and after surgery: highlights from observational study in a single center of China. 61
32328871 2020
11
Left Ventricular Thrombus Formation During Cardiopulmonary Bypass Diagnosed by Intraoperative Transesophageal Echocardiography in a Case of Anomalous Left Coronary Artery From the Pulmonary Artery. 61
32798167 2020
12
Abnormal Origin of the Left Coronary Artery From the Pulmonary Artery Discovered at Age 67: What to Do? 61
30336750 2020
13
Ring of Vieussens: a collateral coronary pathway on electrocardiography-gated 320-row CT in a 10-week-old boy with the anomalous left coronary artery from the pulmonary artery. 61
32347082 2020
14
Anomalous left coronary artery from the pulmonary artery: a rare cause of an out-of-hospital cardiac arrest in an adult-a case report. 61
32617493 2020
15
Surgical outcomes for anomalous left coronary artery from the pulmonary artery: Influence of late presentation. 61
31767362 2020
16
Myocardial Function Following Repair of Anomalous Origin of Left Coronary Artery from the Pulmonary Artery in Children. 61
32122741 2020
17
Commentary: Anomalous left coronary artery from the pulmonary artery-Time is of the essence. 61
31718849 2020
18
A case of robotic assisted percutaneous coronary intervention of the left main coronary artery in a patient with very late baffle stenosis after surgical correction of anomalous left coronary artery from the pulmonary artery. 61
31250510 2020
19
[Reconstruction Using a Saphenous Vein for Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in an Adult;Report of a Case]. 61
32393695 2020
20
Effective myocardial perfusion and concomitant haemodynamic status determine the clinical diversity of anomalous left coronary artery from the pulmonary artery. 61
31964440 2020
21
Diagnosis and Surgical Outcomes of Patients with Anomalous Left Coronary Artery from the Pulmonary Artery: A Single Taiwanese Medical Center Experience. 61
32364892 2020
22
The role of multimodal imaging in the diagnosis of an asymptomatic patient with congenital anomaly. 61
32190864 2020
23
Adult ALCAPA: from histological picture to clinical features. 61
31931842 2020
24
Anomalous left coronary artery from the pulmonary artery (ALCAPA) as a concealed cause of severe mitral regurgitation in children and adults: Case reports. 61
32950944 2020
25
123I-BMIPP/201Tl dual myocardial SPECT proves the efficacy of surgical treatment for an adult with Bland-White-Garland syndrome. 61
31933706 2020
26
N-terminal pro-brain natriuretic peptide levels in patients with anomalous left coronary artery from pulmonary artery. 61
31931857 2020
27
Implantation of a Coronary Sinus Reducer to Treat Refractory Angina in a 38-Year-Old with an Anomalous Left Coronary Artery and No Revascularization Options. 61
32007999 2020
28
Myocardial protection in adult Bland-White-Garland syndrome. 61
31765016 2020
29
Reoperation With Coronary Reimplantation After Takeuchi Repair of Bland-White-Garland Syndrome. 61
31175872 2019
30
Anomalous Left Coronary Artery From The Pulmonary Artery (ALCAPA) as a Cause of Heart Failure. 61
31790381 2019
31
Bland-White-Garland syndrome with aortic stenosis. 61
31536140 2019
32
First report of successfully palliating a hypoplastic left heart syndrome patient with anomalous left coronary artery from the pulmonary artery beyond Fontan. 61
31516293 2019
33
Noonan syndrome associated with anomalous left coronary artery from the pulmonary artery in a patient with the rare RAF1 mutation: A case report and review of literature. 61
31516287 2019
34
Anomalous Left Coronary Artery From the Pulmonary Artery Presenting as Dilated Cardiomyopathy With Regional Wall Motion Abnormality on Point-of-Care Ultrasound. 61
30702648 2019
35
A Kaleidoscope heart. 61
31025758 2019
36
A patient with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA syndrome) and 13 live births. 61
30729975 2019
37
The detection of retrograde flow from the left anterior descending artery into the main pulmonary artery by 4D-flow cardiac magnetic resonance in a patient with Bland-White-Garland syndrome. 61
30629145 2019
38
Anomalous Left Coronary Artery from Pulmonary Artery: An Important Cause of Ischemic Mitral Regurgitation in Children. 61
31245227 2019
39
Reconstruction of anomalous left coronary artery from pulmonary artery in an adult patient: a case report. 61
30808374 2019
40
Anesthetic management in untreated Bland-White-Garland syndrome: a case report and literature review. 61
31406472 2019
41
Myocardial function in patients with anomalous left coronary artery from the pulmonary artery syndrome: A long-term speckle tracking echocardiographic study. 61
31613933 2019
42
An unusual presentation of anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome in a 70-year-old man: a case report. 61
30343670 2018
43
Vascular Network Inside the Heart - Collateral Flow on Color Doppler Echo in a Child With Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA). 61
29628455 2018
44
The outcome of mitral regurgitation after the repair of anomalous left coronary artery from the pulmonary artery in infants and older children. 61
29528421 2018
45
Anomalous Left Coronary Artery From the Pulmonary Artery: Masquerading as Peripartum Cardiomyopathy. 61
29530774 2018
46
Adult-type ALCAPA syndrome: A rare coronary artery anomaly. 61
29749648 2018
47
Anomalous left coronary artery from the pulmonary artery (ALCAPA) diagnosed in adulthood: Varied clinical presentation, therapeutic approach and outcome. 61
29548537 2018
48
Transcatheter closure for baffle leak after Takeuchi repair of anomalous left coronary artery from the pulmonary artery: a case report. 61
31020111 2018
49
Long-term outcome after anomalous left coronary artery from the pulmonary artery repair: a 40-year single-centre experience. 61
29182759 2018
50
Bland-White-Garland syndrome on coronary CT angiography. 61
29636337 2018

Variations for Anomalous Left Coronary Artery from the Pulmonary Artery

Expression for Anomalous Left Coronary Artery from the Pulmonary Artery

Search GEO for disease gene expression data for Anomalous Left Coronary Artery from the Pulmonary Artery.

Pathways for Anomalous Left Coronary Artery from the Pulmonary Artery

GO Terms for Anomalous Left Coronary Artery from the Pulmonary Artery

Cellular components related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intercalated disc GO:0014704 8.62 PKP2 GJA1

Biological processes related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication by electrical coupling involved in cardiac conduction GO:0086064 8.62 PKP2 GJA1

Sources for Anomalous Left Coronary Artery from the Pulmonary Artery

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....