MCID: ANM031
MIFTS: 32

Anomalous Left Coronary Artery from the Pulmonary Artery

Categories: Cardiovascular diseases

Aliases & Classifications for Anomalous Left Coronary Artery from the Pulmonary Artery

MalaCards integrated aliases for Anomalous Left Coronary Artery from the Pulmonary Artery:

Name: Anomalous Left Coronary Artery from the Pulmonary Artery 12 15
Bland White Garland Syndrome 44 73
Bland-White-Garland Syndrome 12
White-Garland Syndrome 12
Alcapa 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060562
MeSH 44 D063748
UMLS 73 C1735886

Summaries for Anomalous Left Coronary Artery from the Pulmonary Artery

Disease Ontology : 12 A coronary artery anomaly in which the left coronary artery (LCA) branches off the pulmonary artery instead of the aortic sinus.

MalaCards based summary : Anomalous Left Coronary Artery from the Pulmonary Artery, also known as bland white garland syndrome, is related to coronary artery anomaly and myocardial infarction. An important gene associated with Anomalous Left Coronary Artery from the Pulmonary Artery is GJA1 (Gap Junction Protein Alpha 1), and among its related pathways/superpathways is Antiarrhythmic Pathway, Pharmacodynamics. Affiliated tissues include heart, skin and spleen, and related phenotypes are Decreased HIV-1 infection and cellular

Related Diseases for Anomalous Left Coronary Artery from the Pulmonary Artery

Diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 coronary artery anomaly 29.7 GJA1 PF4 SMUG1 TET1
2 myocardial infarction 10.5
3 mitral valve insufficiency 10.4
4 arteries, anomalies of 10.3
5 orthostatic intolerance 10.3
6 leber congenital amaurosis 10.3
7 ventricular septal defect 10.3
8 coronary aneurysm 10.3
9 congestive heart failure 10.3
10 cardiomyopathy, dilated, 1o 10.1 GJA1 KCNJ11
11 tricuspid valve stenosis 10.1 CRELD1 GJA1
12 cardiac conduction defect 10.1
13 tetralogy of fallot 10.1
14 endocardial fibroelastosis 10.1
15 patent ductus arteriosus 1 10.1
16 peripartum cardiomyopathy 10.1
17 infective endocarditis 10.1
18 endocarditis 10.1
19 ischemia 10.1
20 myocarditis 10.1
21 aortopulmonary window 10.1
22 coronary artery aneurysm 10.1
23 pulmonary venous return anomaly 10.1
24 endocardium disease 10.1 SMUG1 TAZ
25 mitral valve stenosis 10.1 CRELD1 PF4
26 rectosigmoid junction neoplasm 10.0 KCNJ11 SMUG1
27 secondary hypertrophic osteoarthropathy 10.0 KCNJ11 SMUG1
28 laryngeal tuberculosis 10.0 KCNJ11 SMUG1
29 malignant skin fibrous histiocytoma 10.0 KCNJ11 SMUG1
30 atrial standstill 1 10.0
31 atrial heart septal defect 10.0
32 malignant dermis tumor 10.0 KCNJ11 SMUG1
33 atrioventricular septal defect 10.0 CRELD1 GJA1
34 cogan syndrome 10.0 KCNJ11 SMUG1
35 kleine-levin hibernation syndrome 10.0 KCNJ11 SMUG1
36 spleen angiosarcoma 10.0 SMUG1 VWF
37 platelet aggregation, spontaneous 10.0 PF4 VWF
38 heart valve disease 9.9 CRELD1 VWF
39 lymphangiosarcoma 9.9 SMUG1 VWF
40 blood coagulation disease 9.9 PF4 VWF
41 thrombophilia due to activated protein c resistance 9.9 PF4 VWF
42 atrial fibrillation 9.9 GJA1 PF4 VWF
43 blood platelet disease 9.8 PF4 VWF
44 heart disease 9.6 CRELD1 GJA1 PF4 TAZ VWF

Graphical network of the top 20 diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery:



Diseases related to Anomalous Left Coronary Artery from the Pulmonary Artery

Symptoms & Phenotypes for Anomalous Left Coronary Artery from the Pulmonary Artery

GenomeRNAi Phenotypes related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HIV-1 infection GR00226-A 8.8 KCNJ11 PTPRN2 VWF

MGI Mouse Phenotypes related to Anomalous Left Coronary Artery from the Pulmonary Artery:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 CRELD1 EHD1 GJA1 PDIA3 SMUG1 TAZ
2 homeostasis/metabolism MP:0005376 9.56 EHD1 GJA1 KCNJ11 PF4 PTPRN2 SMUG1
3 mortality/aging MP:0010768 9.23 CRELD1 EHD1 GJA1 KCNJ11 PDIA3 SMUG1

Drugs & Therapeutics for Anomalous Left Coronary Artery from the Pulmonary Artery

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery Terminated NCT00268112

Search NIH Clinical Center for Anomalous Left Coronary Artery from the Pulmonary Artery

Cochrane evidence based reviews: bland white garland syndrome

Genetic Tests for Anomalous Left Coronary Artery from the Pulmonary Artery

Anatomical Context for Anomalous Left Coronary Artery from the Pulmonary Artery

MalaCards organs/tissues related to Anomalous Left Coronary Artery from the Pulmonary Artery:

41
Heart, Skin, Spleen

Publications for Anomalous Left Coronary Artery from the Pulmonary Artery

Articles related to Anomalous Left Coronary Artery from the Pulmonary Artery:

(show top 50) (show all 192)
# Title Authors Year
1
The outcome of mitral regurgitation after the repair of anomalous left coronary artery from the pulmonary artery in infants and older children. ( 29528421 )
2018
2
Anomalous Left Coronary Artery From the Pulmonary Artery: Masquerading as Peripartum Cardiomyopathy. ( 29530774 )
2018
3
Anomalous left coronary artery from the pulmonary artery (ALCAPA) diagnosed in adulthood: Varied clinical presentation, therapeutic approach and outcome. ( 29548537 )
2018
4
Vascular Network Inside the Hearta88- Collateral Flow on Color Doppler Echo in a Child With Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA). ( 29628455 )
2018
5
Presence of reduced regional left ventricular function even in the absence of left ventricular wall scar tissue in the long term after repair of an anomalous left coronary artery from the pulmonary artery. ( 29091021 )
2018
6
Levosimendan for Pediatric Anomalous Left Coronary Artery From the Pulmonary Artery Undergoing Repair: A Single-Center Experience. ( 30155453 )
2018
7
An unusual presentation of anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome in a 70-year-old man: a case report. ( 30343670 )
2018
8
Bland-White-Garland syndrome on coronary CT angiography. ( 29636337 )
2018
9
Bland-White-Garland syndrome in a 39-year-old lumberjack. ( 29984813 )
2018
10
Multimodal Imaging of Anomalous Left Coronary Artery from the Pulmonary Artery in a 75-Year-Old Woman. ( 29276438 )
2017
11
Misdiagnosed anomalous left coronary artery from the pulmonary artery as endocardial fibroelastosis in infancy: A case series. ( 28614263 )
2017
12
Multimodality Imaging of Anomalous Left Coronary Artery from the Pulmonary Artery. ( 29093774 )
2017
13
Long-term outcome after anomalous left coronary artery from the pulmonary artery repair: a 40-year single-centre experience. ( 29182759 )
2017
14
Anomalous Left Coronary Artery from the Pulmonary Artery Presenting with Atypical Chest Pain in an Adult: A Case Report. ( 29062380 )
2017
15
Echocardiographic Diagnosis, Surgical Treatment, and Outcomes of Anomalous Left Coronary Artery from the Pulmonary Artery. ( 28651802 )
2017
16
Cardiac MRI T1 mapping in unrepaired anomalous left coronary artery from the pulmonary artery. ( 28554340 )
2017
17
Late presentation of an anomalous left coronary artery from the pulmonary artery treated with conservative surgical management with long-term cardiac magnetic resonance imaging follow-up. ( 28321308 )
2017
18
Adult Bland-White-Garland syndrome presenting as a sudden cardiac death: successful resuscitation, implantable cardioverter defibrillator and surgery. ( 25062269 )
2017
19
Nicorandil was an Effective Treatment Option for a Patient with Bland-White-Garland Syndrome. ( 28794372 )
2017
20
A case of successful bystander cardiopulmonary resuscitation of an adult with Bland-White-Garland syndrome. ( 29152274 )
2017
21
An adult case of Bland-White-Garland syndrome with collaterals from giant right coronary artery and bronchial artery. ( 30279793 )
2017
22
Whole Exome Sequencing in a Rare Disease: A Patient with Anomalous Left Coronary Artery from the Pulmonary Artery (Bland-White-Garland Syndrome). ( 27195969 )
2016
23
Bypassing the Pump: Midterm Follow-Up of an Off-Pump Technique for Anomalous Left Coronary Artery From the Pulmonary Artery. ( 27098608 )
2016
24
Midterm outcome after surgical correction of anomalous left coronary artery from the pulmonary artery. ( 27562655 )
2016
25
Anomalous left coronary artery from the pulmonary artery discovered following total anomalous pulmonary venous return repair: a rare entity. ( 27573031 )
2016
26
Anomalous Left Coronary Artery From the Pulmonary Artery in Infants and Toddlers Misdiagnosed as Myocarditis. ( 26414630 )
2016
27
A Rare Case of Anomalous Left Coronary Artery From the Pulmonary Artery (Bland-White-Garland Syndrome) in a 68-Year-Old Woman. ( 27401860 )
2016
28
Unusual Survival of Anomalous Left Coronary Artery From the Pulmonary Artery With Severe Rheumatic Mitral Stenosis in Septuagenarian Women: Foes Becoming Friends? ( 27635184 )
2016
29
A curious course of an intramural anomalous left coronary artery from the pulmonary artery. ( 27993364 )
2016
30
Contrast Media Delivery in the Assessment of Anomalous Left Coronary Artery From the Pulmonary Artery. ( 27146172 )
2016
31
Coronary Artery Bypass Grafting for an Anomalous Left Coronary Artery from the Pulmonary Artery in a 73-Year-Old Female. ( 27102973 )
2016
32
Surgical Treatment of an Anomalous Left Coronary Artery From the Pulmonary Artery in a Sexagenarian Woman. ( 26971237 )
2016
33
Temporary left ventricular assistance for extreme postoperative heart failure in two infants with Bland-White-Garland syndrome. ( 27785147 )
2016
34
Two adult cases of Bland-White-Garland syndrome with lethal arrhythmia due to coronary steal phenomenon during physical or mental stress. ( 30546646 )
2016
35
Oblique coronary artery prolongation approach in anomalous left coronary artery from the pulmonary artery in a low-birth-weight neonate. ( 25870360 )
2015
36
Repair of anomalous left coronary artery from the pulmonary artery in the modern era: preoperative predictors of immediate postoperative outcomes and long term cardiac follow-up. ( 25301273 )
2015
37
Takeuchi repair of anomalous left coronary artery from the pulmonary artery. ( 25843240 )
2015
38
Combined Non-Invasive Doppler Echocardiography and Coronary Computed Tomography Lead to Diagnosis of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA) Syndrome. ( 25739407 )
2015
39
Unusual late clinical manifestation of Bland-White-Garland syndrome as sudden cardiac death survival. ( 25412599 )
2015
40
Bland-White-Garland syndrome. ( 24890555 )
2015
41
Bland-White-Garland syndrome diagnosed by computed tomography. ( 26313868 )
2015
42
Mechanical circulatory support after surgical repair of Bland-White-Garland syndrome. A study of three cases. ( 26336486 )
2015
43
Repair of Bland-White-Garland Syndrome via a Modified Technique. ( 26504455 )
2015
44
Aneurysm of the Left Coronary Artery in Postoperative Bland-White-Garland Syndrome. ( 26770839 )
2015
45
Midterm results of left coronary artery reimplantation through the transverse sinus of the pericardium in adult Bland-White-Garland syndrome. ( 26943392 )
2015
46
Giant coronary artery aneurysm after takeuchi repair for anomalous left coronary artery from the pulmonary artery. ( 24169018 )
2014
47
Myocardial perfusion, scarring, and function in anomalous left coronary artery from the pulmonary artery syndrome: a long-term analysis using magnetic resonance imaging. ( 25130077 )
2014
48
Left ventricular thrombus formation after repair of anomalous left coronary artery from the pulmonary artery. ( 24668990 )
2014
49
Surviving sudden cardiac death secondary to anomalous left coronary artery from the pulmonary artery: a case report and literature review. ( 25012636 )
2014
50
Cardiovascular magnetic resonance assessment of ventricular function and myocardial scarring before and early after repair of anomalous left coronary artery from the pulmonary artery. ( 24387660 )
2014

Variations for Anomalous Left Coronary Artery from the Pulmonary Artery

Expression for Anomalous Left Coronary Artery from the Pulmonary Artery

Search GEO for disease gene expression data for Anomalous Left Coronary Artery from the Pulmonary Artery.

Pathways for Anomalous Left Coronary Artery from the Pulmonary Artery

Pathways related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.37 GJA1 KCNJ11

GO Terms for Anomalous Left Coronary Artery from the Pulmonary Artery

Cellular components related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.33 CRELD1 PF4 VWF
2 platelet alpha granule lumen GO:0031093 9.26 PF4 VWF
3 intercalated disc GO:0014704 8.96 GJA1 KCNJ11
4 myelin sheath GO:0043209 8.8 EHD1 KCNJ11 PDIA3

Biological processes related to Anomalous Left Coronary Artery from the Pulmonary Artery according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ischemia GO:0002931 8.62 GJA1 KCNJ11

Sources for Anomalous Left Coronary Artery from the Pulmonary Artery

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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73 UMLS
74 UMLS via Orphanet
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