MCID: ANR003
MIFTS: 32

Anorectal Stricture

Categories: Gastrointestinal diseases

Aliases & Classifications for Anorectal Stricture

MalaCards integrated aliases for Anorectal Stricture:

Name: Anorectal Stricture 12 15 70
Stenosis of Rectum and Anus 12
Anorectal Malformations 44

Classifications:



External Ids:

Disease Ontology 12 DOID:11014
ICD9CM 34 569.2
MeSH 44 D000071056
SNOMED-CT 67 197216007
ICD10 32 K62.4
UMLS 70 C0156183

Summaries for Anorectal Stricture

MalaCards based summary : Anorectal Stricture, also known as stenosis of rectum and anus, is related to intestinal obstruction and intestinal perforation. An important gene associated with Anorectal Stricture is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Matrix Metalloproteinases and Angiogenesis (CST). The drugs Bisacodyl and Cola have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, and related phenotypes are cardiovascular system and cellular

Related Diseases for Anorectal Stricture

Diseases related to Anorectal Stricture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 30.0 TNF NOD2 CRP
2 intestinal perforation 29.5 TNF NOD2 CRP
3 perinatal necrotizing enterocolitis 29.5 TNF NOD2 CRP
4 rectal disease 29.5 TNF NOD2 CRP
5 crohn's disease 28.8 TPMT TNFSF15 TNF NOD2 IRGM DLG5
6 bifid nose with or without anorectal and renal anomalies 11.5
7 anus, imperforate 11.5
8 currarino syndrome 11.1
9 vater/vacterl association 11.1
10 constipation 10.9
11 anorectal anomalies 10.6
12 hirschsprung disease 1 10.5
13 pelvic organ prolapse 10.5
14 esophageal atresia 10.5
15 acute cystitis 10.5
16 neurogenic bladder 10.4
17 urinary tract infection 10.4
18 urethral diverticulum 10.4
19 lipomatosis, multiple 10.4
20 tracheoesophageal fistula with or without esophageal atresia 10.4
21 pleomorphic lipoma 10.4
22 tethered spinal cord syndrome 10.3
23 hydronephrosis 10.3
24 neural tube defects 10.3
25 renal hypodysplasia/aplasia 1 10.3
26 vesicoureteral reflux 1 10.3
27 vacterl association 10.3
28 drug reaction with eosinophilia and systemic symptoms 10.2 TNF CRP
29 anterior scleritis 10.2 TNF CRP
30 rheumatoid arthritis interstitial lung disease 10.2 TNF CRP
31 posterior scleritis 10.2 TNF CRP
32 skeletal tuberculosis 10.2 TNF CRP
33 tuberculous epididymitis 10.2 TNF CRP
34 meningovascular neurosyphilis 10.2 TNF CRP
35 critical illness polyneuropathy 10.2 TNF CRP
36 louse-borne relapsing fever 10.2 TNF CRP
37 opportunistic bacterial infectious disease 10.2 TNF CRP
38 down syndrome 10.2
39 orchitis 10.2
40 teratoma 10.2
41 chromosomal triplication 10.2
42 tertiary syphilis 10.2 TNF CRP
43 nocardiosis 10.2 TNF CRP
44 arachnoiditis 10.2 TNF CRP
45 soft tissue sarcoma 10.2 TNF CRP
46 oral tuberculosis 10.2 TNF CRP
47 cerebritis 10.2 TNF CRP
48 aspiration pneumonitis 10.2 TNF CRP
49 inflammatory and toxic neuropathy 10.2 TNF CRP
50 granulomatous hepatitis 10.2 TNF CRP

Graphical network of the top 20 diseases related to Anorectal Stricture:



Diseases related to Anorectal Stricture

Symptoms & Phenotypes for Anorectal Stricture

MGI Mouse Phenotypes related to Anorectal Stricture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ATG16L1 CLDN4 CRP ETS1 PRDM1 RBL2
2 cellular MP:0005384 10 ATG16L1 CLDN4 DLG5 ETS1 NOD2 PRDM1
3 hematopoietic system MP:0005397 9.93 ATG16L1 CLDN4 ETS1 KLRB1 NCF4 NOD2
4 homeostasis/metabolism MP:0005376 9.83 ATG16L1 CLDN4 CRP DLG5 ETS1 IRGM
5 immune system MP:0005387 9.36 ATG16L1 CRP ETS1 KLRB1 NCF4 NOD2

Drugs & Therapeutics for Anorectal Stricture

Drugs for Anorectal Stricture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisacodyl Approved 603-50-9
2 Cola
3 Antibiotics, Antitubercular
4 Anti-Bacterial Agents
5 Central Nervous System Stimulants
6 Cathartics
7 Laxatives

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 NASHA/Dx as a Perianal Implant for the Treatment of Persistent Fecal Incontience After Anorectal Malformation Completed NCT03746834 Phase 4
2 Laparoscopically Assisted Anorectal Pull-through Versus Posterior Sagittal Anorectoplasty for High and Intermediate Anorectal Malformations : A Comparative Study Unknown status NCT03174028
3 Long-term Outcome in Patients Operated for Congenital Anorectal Malformations Unknown status NCT02624232
4 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
5 Urodynamic Evaluation in Patients With Anorectal Malformation According to Spinal Cord Abnormalities Completed NCT00909415
6 National Study on the Quality of Life of Patients With Anorectal Malformation (MARQOL) Completed NCT02029248
7 3D High Resolution Anorectal Manometry in Children After Surgery for Anorectal Disorders Completed NCT02296008
8 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries: A Multi-Centre, International, Prospective Cohort Study Completed NCT03666767
9 Comparative Study of the House Advancement Flap, Rhomboid Flap, and Y-V Anoplasty in Treatment of Anal Stenosis: A Prospective Randomized Study Completed NCT00883571
10 Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation: a Case-control Study on Invasive and Non-invasive Neuromodulatory Treatment Recruiting NCT04713085
11 Non-invasive Sacral Nerve Stimulation in Children and Adolescents With Chronic Constipation: a Case-control Study on External Neuromodulatory Treatment Recruiting NCT04710433
12 Translation and Validation of the Hirschsprung and Anorectal Malformation Quality of Life (HAQL) Questionnaire in a Danish Hirschsprung Population Recruiting NCT04730128
13 Transition of Care for Patients With Hirschsprung Disease and Anorectal Malformations Enrolling by invitation NCT04106947

Search NIH Clinical Center for Anorectal Stricture

Cochrane evidence based reviews: anorectal malformations

Genetic Tests for Anorectal Stricture

Anatomical Context for Anorectal Stricture

MalaCards organs/tissues related to Anorectal Stricture:

40
Spinal Cord

Publications for Anorectal Stricture

Articles related to Anorectal Stricture:

(show all 22)
# Title Authors PMID Year
1
Comparison of the short-term outcomes of using DST and PPH staplers in the treatment of grade III and IV hemorrhoids. 61
32251336 2020
2
Late-onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. 61
31322729 2019
3
Experience with the Redo Pull-Through for Hirschsprung's Disease. 61
30686887 2019
4
High grade anorectal stricture complicating Crohn's disease: endoscopic treatment using insulated-tip knife. 61
27433152 2016
5
Transanal anorectal stricturoplasty using the Heineke-Mikulicz principle: a novel technique. 61
26247634 2016
6
Anorectal stricture in 102 patients with Crohn's disease: natural history in the era of biologics. 61
25109493 2014
7
Comparing the effect of An's Shaobei Injection ([symbols; see text]) with Xiaozhiling Injection ([symbols; see text]) in patients with internal hemorrhoids of grade I-III: a prospective cohort study. 61
24972583 2014
8
Rectal perforation caused by anal stricture after hemorrhoid treatment. 61
23586012 2013
9
A New Technique Using Ultra-slim Endoscopy for High-Grade Crohn's Stricture. 61
23185708 2012
10
New application of the gluteal-fold flap for the treatment of anorectal stricture. 61
21212967 2011
11
Long-term efficacy of infliximab maintenance therapy for perianal Crohn's disease. 61
21448422 2011
12
The morbidity of constipation in patients with anorectal malformations. 61
20620325 2010
13
Rectal lumen obliteration from stapled hemorrhoidopexy: can it be prevented? 61
19768522 2009
14
Transanal coloanal anastomosis for Hirschsprung's disease: comparison between endorectal and perirectal pull-through procedures. 61
17160774 2006
15
Experience of 3711 stapled haemorrhoidectomy operations. 61
16323166 2006
16
[Role of color Doppler echography in the visualization of perianal fistulae with injections of physiologic solutions]. 61
11155449 2000
17
Rectal sleeve advancement: repair of rectovaginal fistula associated with anorectal stricture in Crohn's disease. 61
9645750 1998
18
[Stenosing anal mass and venereal lymphogranuloma]. 61
7939526 1994
19
Magnetic resonance imaging facilitates assessment of perianal Crohn's disease. 61
8010916 1994
20
Hirschsprung's disease. Identification of risk factors for enterocolitis. 61
2964227 1988
21
Carcinoma in anorectal fistula of rectal mucosal origin. 61
6087605 1984
22
Congenital anorectal stricture. 61
15422490 1950

Variations for Anorectal Stricture

Expression for Anorectal Stricture

Search GEO for disease gene expression data for Anorectal Stricture.

Pathways for Anorectal Stricture

Pathways related to Anorectal Stricture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 TNF TIMP3 TIMP2
2 11.08 TIMP3 TIMP2 ETS1
3 10.7 TNF KLRB1 ETS1

GO Terms for Anorectal Stricture

Biological processes related to Anorectal Stricture according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.77 CRP ETS1 PRDM1 TNF TWIST1
2 defense response to Gram-positive bacterium GO:0050830 9.67 CRP NOD2 TNF
3 positive regulation of interleukin-6 production GO:0032755 9.61 NOD2 TNF TWIST1
4 response to organic substance GO:0010033 9.58 TIMP2 TIMP3 TNF
5 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.48 ETS1 TNF
6 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.46 NOD2 TWIST1
7 negative regulation of lipid storage GO:0010888 9.32 TNF CRP
8 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.26 TIMP3 TIMP2
9 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.16 IRGM NOD2
10 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 8.96 NOD2 TNF
11 protein lipidation involved in autophagosome assembly GO:0061739 8.62 ATG16L1 IRGM

Molecular functions related to Anorectal Stricture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase inhibitor activity GO:0008191 9.16 TIMP3 TIMP2
2 CARD domain binding GO:0050700 8.96 IRGM NOD2
3 protease binding GO:0002020 8.8 TNF TIMP3 TIMP2

Sources for Anorectal Stricture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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