MCID: ANS006
MIFTS: 34

Anosognosia

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Anosognosia

MalaCards integrated aliases for Anosognosia:

Name: Anosognosia 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060133
UMLS 70 C0234507

Summaries for Anosognosia

Disease Ontology : 12 An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments.

MalaCards based summary : Anosognosia is related to apraxia and amnestic disorder, and has symptoms including other general symptoms An important gene associated with Anosognosia is APOE (Apolipoprotein E), and among its related pathways/superpathways are Neuroscience and Alzheimers Disease Pathway. Affiliated tissues include brain, parietal lobe and cortex, and related phenotypes are nervous system and respiratory system

Wikipedia : 73 Anosognosia is a condition in which a person with a disability is cognitively unaware of having it due... more...

Related Diseases for Anosognosia

Diseases related to Anosognosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 apraxia 30.3 PSEN1 C9orf72 APOE
2 amnestic disorder 30.1 PSEN1 HTR1A APOE
3 aphasia 30.1 PSEN1 PLG C9orf72 APOE
4 agraphia 30.0 C9orf72 APOE
5 simultanagnosia 29.9 PSEN1 APOE
6 anterograde amnesia 29.8 HTR1A APOE
7 frontotemporal dementia 29.8 PSEN1 C9orf72 APOE
8 stroke, ischemic 29.4 RTN4 PSEN1 PLG APOE
9 amyotrophic lateral sclerosis 1 29.2 RTN4 PSEN1 CDR2 CDR1 C9orf72 APOE
10 anton's syndrome 11.0
11 hemiplegia 10.8
12 mild cognitive impairment 10.5
13 alzheimer disease 10.5
14 dementia 10.4
15 yemenite deaf-blind hypopigmentation syndrome 10.3
16 cortical blindness 10.2
17 paraneoplastic cerebellar degeneration 10.2 CDR2 CDR1
18 cerebellar degeneration 10.2 CDR2 CDR1
19 acute diffuse nephritis 10.2 CDR2 CDR1
20 ideomotor apraxia 10.2 C9orf72 APOE
21 alzheimer disease 7 10.2 C9orf72 APOE
22 agnosia 10.1
23 schuurs-hoeijmakers syndrome 10.1 CDR2 CDR1
24 gerstmann syndrome 10.1 PSEN1 APOE
25 visual agnosia 10.1 PSEN1 APOE
26 lateral sclerosis 10.1
27 basal ganglia cerebrovascular disease 10.1 PLG APOE
28 alzheimer disease 2 10.1 PSEN1 APOE
29 cerebral amyloid angiopathy, app-related 10.1 PSEN1 APOE
30 progressive non-fluent aphasia 10.1 PSEN1 C9orf72
31 alzheimer disease 4 10.0 PSEN1 APOE
32 communicating hydrocephalus 10.0 PSEN1 APOE
33 alcohol dependence 10.0
34 huntington disease 10.0
35 schizophrenia 10.0
36 branchiootic syndrome 1 10.0
37 brain injury 10.0
38 early-onset, autosomal dominant alzheimer disease 10.0 PSEN1 APOE
39 alzheimer disease 3 10.0 PSEN1 APOE
40 ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 10.0 PSEN1 APOE
41 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 10.0 PSEN1 APOE
42 hand skill, relative 9.9
43 cortical deafness 9.9
44 alexia 9.9
45 mood disorder 9.9
46 capgras syndrome 9.9
47 head injury 9.9
48 nominal aphasia 9.9 PSEN1 C9orf72 APOE
49 semantic dementia 9.9 PSEN1 C9orf72 APOE
50 normal pressure hydrocephalus 9.9 PSEN1 C9orf72 APOE

Graphical network of the top 20 diseases related to Anosognosia:



Diseases related to Anosognosia

Symptoms & Phenotypes for Anosognosia

UMLS symptoms related to Anosognosia:


other general symptoms

MGI Mouse Phenotypes related to Anosognosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 APOE C9orf72 HTR1A PLG PROP1 PSEN1
2 respiratory system MP:0005388 9.02 APOE C9orf72 PLG PROP1 PSEN1

Drugs & Therapeutics for Anosognosia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe Unknown status NCT02333006
2 FMRI of Anosognosia in Amnestic MCI and AD: Focus on Cortical Midline Structures Completed NCT00908999
3 Cognitive and Cerebral Mechanisms of Anosognosia in Patients With Acquired Brain Damage: New Evaluation Strategies Based on Daily Tasks Enrolling by invitation NCT03712839
4 Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study to Examine the Effects of Anosognosia on Self-Reported Quality of Life for People With Parkinson's Withdrawn NCT02561715

Search NIH Clinical Center for Anosognosia

Genetic Tests for Anosognosia

Anatomical Context for Anosognosia

MalaCards organs/tissues related to Anosognosia:

40
Brain, Parietal Lobe, Cortex, Eye, Occipital Lobe, Cingulate Cortex, Kidney

Publications for Anosognosia

Articles related to Anosognosia:

(show top 50) (show all 754)
# Title Authors PMID Year
1
Exploring the relationship between impaired illness awareness and visuospatial inattention in patients with schizophrenia. 61
33168197 2021
2
Unravelling the neural basis of spatial delusions after stroke. 61
33811370 2021
3
Anosognosia for limb and bucco-facial apraxia as inferred from the recognition of gestural errors. 61
32080980 2021
4
Effect of Prism Adaptation Therapy on the Activities of Daily Living and Awareness for Spatial Neglect: A Secondary Analysis of the Randomized, Controlled Trial. 61
33803412 2021
5
White matter network disruption and cognitive correlates underlying impaired memory awareness in mild cognitive impairment. 61
33780863 2021
6
Singularity and consciousness: A neuropsychological contribution. 61
33522716 2021
7
The Motor Unawareness Assessment (MUNA): A new tool for the assessment of Anosognosia for hemiplegia. 61
33588707 2021
8
Auditory agnosia with anosognosia. 61
33647851 2021
9
Anosognosia for memory in dementia with Lewy bodies compared with Alzheimer's disease. 61
33594752 2021
10
Functional connectivity differences in Alzheimer's disease and amnestic mild cognitive impairment associated with AT(N) classification and anosognosia. 61
33561787 2021
11
Cerebral trauma-induced dyschromatopsia in the left hemifield: case presentation. 61
33504343 2021
12
Altered awareness of cognitive and neuropsychiatric symptoms in Parkinson's disease and Dementia with Lewy Bodies: A systematic review. 61
32869379 2021
13
The importance of the insular cortex for vestibular and spatial syndromes. 61
33270346 2020
14
Long-term cognitive disability after traumatic brain injury: Contribution of the DEX relative questionnaires. 61
31116085 2020
15
A combined therapy for limb apraxia and related anosognosia. 61
31210088 2020
16
Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease. 61
33263761 2020
17
In schizophrenia, are lack of capacity and lack of insight more usefully understood as anosognosia? 61
33347780 2020
18
Anosognosia for theory of mind deficits: A single case study and a review of the literature. 61
33058921 2020
19
Anton's syndrome as a presentation of Trousseau syndrome involving the bilateral optic radiation. 61
33233982 2020
20
Anosognosia in amyotrophic lateral sclerosis: a cross-sectional study of 85 individuals and their relatives. 61
33065300 2020
21
What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review. 61
32679396 2020
22
Awareness of cognitive abilities in the execution of activities of daily living after acquired brain injury: an evaluation protocol. 61
33109646 2020
23
Mnemonic monitoring in anosognosia for memory loss. 61
32852998 2020
24
Neuroanatomical and cognitive correlates of domain-specific anosognosia in early Alzheimer's disease. 61
32534349 2020
25
The predictors of proxy- and self-reported quality of life among individuals with acquired brain injury. 61
32847433 2020
26
Cognitive anosognosia is associated with frontal dysfunction and lower depression in Parkinson's disease. 61
32090410 2020
27
Patients' experiences of unilateral spatial neglect between stroke onset and discharge from inpatient rehabilitation: a thematic analysis of qualitative interviews. 61
30466328 2020
28
How is carer strain related to the recovery of stroke survivors with right hemisphere dysfunction? Implications for practice. 61
32543914 2020
29
Neuropsychological Correlates of Anosognosia for Objective Functional Difficulties in Older Adults on the Mild Cognitive Impairment Spectrum. 61
31875876 2020
30
Anosognosia in patients with Alzheimer's disease: current perspectives. 61
31930617 2020
31
Anton's Syndrome associated with autotopagnosia. 61
30661390 2020
32
Anosognosia and schizophrenia - a reminder. 61
32469641 2020
33
Measuring Awareness in People With Dementia: Results of a Systematic Scoping Review. 61
32400259 2020
34
Speech-Language Pathology Practices for Adults With Right Hemisphere Stroke: What Are We Missing? 61
32330389 2020
35
Evaluation of a performance-rating method to assess awareness of cognitive functioning in Huntington's disease. 61
31322031 2020
36
Hippocampal diaschisis contributes to anosognosia for hemiplegia: Evidence from lesion network-symptom-mapping. 61
31870945 2020
37
Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. 61
31696223 2020
38
The behavioral presentation of an individual with a disordered sense of self. 61
31977238 2020
39
Evolution of anosognosia in alzheimer's disease and its relationship to amyloid. 61
31750553 2020
40
Impact of a Healing Garden on Self-Consciousness in Patients with Advanced Alzheimer's Disease: An Exploratory Study1. 61
32444537 2020
41
Novel Alzheimer's disease subtypes identified using a data and knowledge driven strategy. 61
31992745 2020
42
Awareness of Chorea in Huntington's Disease. 61
31707371 2020
43
The Impact of Anosognosia on Clinical and Patient-Reported Assessments of Psychiatric Symptoms in Huntington's Disease. 61
32925080 2020
44
CADASIL presenting as late-onset mania with anosognosia. 61
31998484 2020
45
Anosognosia Is Associated With Greater Caregiver Burden and Poorer Executive Function in Huntington Disease. 61
31213121 2020
46
The Merging Tracks of Anosognosia and Neglect. 61
32927461 2020
47
Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation. 61
31713017 2020
48
Understanding Anosognosia for Hemiplegia After Stroke. 61
30086101 2020
49
Dissociations between perception and awareness in hemianopia. 61
31929128 2020
50
Understanding Anosognosia for Hemiplegia After Stroke. 61
31876873 2020

Variations for Anosognosia

Expression for Anosognosia

Search GEO for disease gene expression data for Anosognosia.

Pathways for Anosognosia

Pathways related to Anosognosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 RTN4 PSEN1 HTR1A APOE
2 10.91 PSEN1 APOE
3
Show member pathways
10.62 RTN4 PSEN1 PLG
4 10.52 PSEN1 PLG

GO Terms for Anosognosia

Cellular components related to Anosognosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.92 PSEN1 HTR1A C9orf72 APOE

Biological processes related to Anosognosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 PSEN1 PLG APOE
2 gene expression GO:0010467 9.4 PSEN1 APOE
3 negative regulation of amyloid-beta formation GO:1902430 9.32 RTN4 APOE
4 positive regulation of dendritic spine development GO:0060999 9.26 PSEN1 APOE
5 negative regulation of axonogenesis GO:0050771 9.16 RTN4 PSEN1
6 amyloid precursor protein metabolic process GO:0042982 8.96 PSEN1 APOE
7 positive regulation of amyloid fibril formation GO:1905908 8.62 PSEN1 APOE

Sources for Anosognosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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