MCID: ANS006
MIFTS: 36

Anosognosia

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Anosognosia

MalaCards integrated aliases for Anosognosia:

Name: Anosognosia 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060133
UMLS 74 C0234507

Summaries for Anosognosia

Disease Ontology : 12 An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments.

MalaCards based summary : Anosognosia is related to alexia and anton's syndrome, and has symptoms including other general symptoms An important gene associated with Anosognosia is ECI1 (Enoyl-CoA Delta Isomerase 1), and among its related pathways/superpathways is A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, parietal lobe and testes, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 77 Anosognosia is a deficit of self-awareness, a condition in which a person with a disability seems... more...

Related Diseases for Anosognosia

Diseases related to Anosognosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 alexia 30.0 APOE KANTR WDFY2
2 anton's syndrome 11.5
3 alzheimer disease 10.8
4 hemiplegia 10.8
5 dementia 10.6
6 depression 10.4
7 alzheimer disease 4 10.3 APOE PSEN2
8 locked-in syndrome 10.3 EP300 PLG
9 dysbaric osteonecrosis 10.3 ECI1 PLG
10 cerebral atherosclerosis 10.3 APOE MTHFR
11 gait apraxia 10.2 APOE CDR2
12 posterolateral myocardial infarction 10.2 KANTR PLG
13 acute anterolateral myocardial infarction 10.2 KANTR PLG
14 facial neuralgia 10.2 KANTR PLG
15 cerebral falx meningioma 10.2 KANTR PLG
16 cerebral arteritis 10.2 KANTR PLG
17 leech infestation 10.2 KANTR PLG
18 aphasia 10.2
19 cortical blindness 10.2
20 intracranial vasospasm 10.2 APOE KANTR
21 apical myocardial infarction 10.2 KANTR PLG
22 auditory agnosia 10.2 EP300 KANTR
23 alveolar periostitis 10.1 KANTR PLG
24 livedoid vasculitis 10.1 MTHFR PLG
25 amyotrophic lateral sclerosis 1 10.1
26 schizophrenia 10.1
27 apraxia 10.1
28 lateral sclerosis 10.1
29 cochlear disease 10.1 GATA3 KANTR
30 anteroseptal myocardial infarction 10.1 KANTR PLG
31 anterior cranial fossa meningioma 10.1 KANTR PLG
32 visual agnosia 10.1 KANTR PSEN2
33 partial fetal alcohol syndrome 10.1 EP300 RTN4
34 brown-sequard syndrome 10.1 KANTR PLG
35 arteries, anomalies of 10.1 APOE KANTR PLG
36 speech and communication disorders 10.1 APOE KANTR PLG
37 brain injury 10.1
38 amnestic disorder 10.1
39 agnosia 10.1
40 capgras syndrome 10.1
41 retinal vascular occlusion 10.0 MTHFR PLG
42 accommodative esotropia 10.0 KANTR WDFY2
43 carotid artery dissection 10.0 KANTR MTHFR PLG
44 multiple personality disorder 10.0 CCAR1 WDFY2
45 cerebellar degeneration 10.0 CDR1 CDR2
46 nervous system disease 10.0 APOE KANTR PLG
47 disease of mental health 9.9 APOE EP300 RTN4
48 tardive dyskinesia 9.9
49 cognitive function 1, social 9.9
50 ataxia and polyneuropathy, adult-onset 9.9

Graphical network of the top 20 diseases related to Anosognosia:



Diseases related to Anosognosia

Symptoms & Phenotypes for Anosognosia

UMLS symptoms related to Anosognosia:


other general symptoms

MGI Mouse Phenotypes related to Anosognosia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 APOE BCS1L CBSL ECI1 EP300 EPHX2
2 endocrine/exocrine gland MP:0005379 9.86 APOE BCS1L CBSL EP300 GATA3 PLG
3 renal/urinary system MP:0005367 9.56 APOE BCS1L CBSL ECI1 EP300 GATA3
4 vision/eye MP:0005391 9.23 APOE CBSL EP300 EPHX2 GATA3 MTHFR

Drugs & Therapeutics for Anosognosia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Perception and Multisensory Integration in Neurological Patients Using fMRI Unknown status NCT01469858 Not Applicable
2 Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) Completed NCT00908999
3 Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS Completed NCT02537496 Not Applicable
4 Anosognosia Evaluation After Cranocerebral Trauma Moderate to Severe Recruiting NCT02333006 Not Applicable
5 Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson's Recruiting NCT02561715
6 The Effects of tDCS on Illness Awareness in Schizophrenia Recruiting NCT02848885 Not Applicable
7 An Executive/Monitoring Treatment Protocol on Everyday Life Activities Recruiting NCT03958487 Not Applicable
8 Combining Physical Therapy With Vestibular Stimulation to Improve Postural Stability in Pusher's Syndrome Recruiting NCT03831594 Not Applicable
9 Cognitive-functional Evaluation of Anosognosia Enrolling by invitation NCT03712839
10 Processing Integration in Neurological Patients Using fMRI Not yet recruiting NCT02722070

Search NIH Clinical Center for Anosognosia

Genetic Tests for Anosognosia

Anatomical Context for Anosognosia

MalaCards organs/tissues related to Anosognosia:

42
Brain, Parietal Lobe, Testes, Cortex, Appendix, Cingulate Cortex, Caudate Nucleus

Publications for Anosognosia

Articles related to Anosognosia:

(show top 50) (show all 295)
# Title Authors Year
1
Interaction between memory impairment and depressive symptoms can exacerbate anosognosia: a comparison of Alzheimer's disease with mild cognitive impairment. ( 29528693 )
2019
2
Online and offline awareness deficits: Anosognosia for spatial neglect. ( 29648845 )
2019
3
Anosognosia of financial ability in mild cognitive impairment. ( 30968462 )
2019
4
A case of somatoparaphrenia characterized by very mild somatosensory disturbance and absence of anosognosia for hemiplegia and personal neglect. ( 30979503 )
2019
5
Olfactory anosognosia is a predictor of cognitive decline and dementia conversion in Parkinson's disease. ( 31011798 )
2019
6
Anosognosia, denial of illness and the right hemisphere dominance for emotions: Some historical and clinical notes. ( 29102412 )
2018
7
Examining Anosognosia of Neglect. ( 29251546 )
2018
8
Different impact of prism adaptation rehabilitation in spatial neglect and anosognosia for hemiplegia. ( 29357315 )
2018
9
Anosognosia in mild Alzheimer's disease is correlated with not only neural dysfunction but also compensation. ( 29409154 )
2018
10
Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. ( 29444971 )
2018
11
Cross domain self-monitoring in anosognosia for memory loss in Alzheimer's disease. ( 29518705 )
2018
12
Assessing Anosognosia in Apraxia of Common Tool-Use With the VATA-NAT. ( 29636672 )
2018
13
Anosognosia for cognitive and behavioral symptoms in Parkinson's disease with mild dementia and mild cognitive impairment: Frequency and neuropsychological/neuropsychiatric correlates. ( 29709507 )
2018
14
Anosognosia. ( 29731103 )
2018
15
Neural Correlates of Anosognosia in Alzheimer's Disease and Mild Cognitive Impairment: A Multi-Method Assessment. ( 29867398 )
2018
16
Teaching NeuroImages: Distinct visual anosognosia after serial lesions of Meyer loop and the lateral geniculate body. ( 29967211 )
2018
17
Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients. ( 30056422 )
2018
18
Understanding Anosognosia for Hemiplegia After Stroke. ( 30086101 )
2018
19
Over- and underestimation of motor ability after a stroke: Implications for anosognosia. ( 30098977 )
2018
20
Anosognosia in degenerative brain diseases: The role of the right hemisphere and of its dominance for emotions. ( 30179807 )
2018
21
Anosognosia for chronic dysphagia. ( 30292345 )
2018
22
Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease. ( 28421896 )
2017
23
Repressive Coping Does Not Contribute to Anosognosia in First-Diagnosis Patients With Alzheimer Disease. ( 27819840 )
2017
24
The "self-awareness-anosognosia" paradox explained: How can one process be associated with activation of, and damage to, opposite sides of the brain? ( 27093371 )
2017
25
Mnemonic anosognosia in Alzheimer's disease is caused by a failure to transfer online evaluations of performance: Evidence from memory training programs. ( 27677926 )
2017
26
The Proactive Self in Space: How Egocentric and Allocentric Spatial Impairments Contribute to Anosognosia in Alzheimer's Disease. ( 27767990 )
2017
27
Cognitive and anatomical correlates of anosognosia in amnestic mild cognitive impairment and early-stage Alzheimer's disease. ( 27780496 )
2017
28
Integrating the Constructs of Anosognosia and Metacognition: a Review of Recent Findings in Dementia. ( 28283961 )
2017
29
A Framework for Ethical Decision Making in the Rehabilitation of Patients with Anosognosia. ( 28436930 )
2017
30
Modulating anosognosia for hemiplegia: The role of dangerous actions in emergent awareness. ( 28501758 )
2017
31
Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. ( 28616381 )
2017
32
Brain regions associated with anosognosia for memory disturbance in Alzheimer's disease: a magnetic resonance imaging study. ( 28740390 )
2017
33
Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism. ( 29022655 )
2017
34
Double Disassociation of Anosognosia for Alexia and Simultanagnosia but Quantitative Awareness of Optic Ataxia. ( 26368835 )
2016
35
Anosognosia in Alzheimer disease: Prevalence, associated factors, and influence on disease progression. ( 25976940 )
2016
36
Clinical factorial distribution of Anosognosia Questionnaire for Dementia (AQ-D) in a sample of patients with Alzheimer's disease. ( 27059694 )
2016
37
The Longitudinal Association Between a Discrepancy Measure of Anosognosia in Patients with Dementia, Caregiver Burden and Depression. ( 27258415 )
2016
38
Presence or absence of cognitive complaints in Parkinson's disease: mood disorder or anosognosia? ( 27332067 )
2016
39
Anosognosia in Dementia. ( 27438597 )
2016
40
Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory. ( 27447979 )
2016
41
Motor versus body awareness: Voxel-based lesion analysis in anosognosia for hemiplegia and somatoparaphrenia following right hemisphere stroke. ( 27494375 )
2016
42
Consequences of Anosognosia on the Cost of Caregivers' Care in Alzheimer's Disease. ( 27636844 )
2016
43
Mood-congruent recollection and anosognosia in Alzheimer's disease. ( 27697664 )
2016
44
Examination of the metacognitive errors that contribute to anosognosia in Alzheimer's disease. ( 27750070 )
2016
45
Blissfully unaware: Anosognosia and anosodiaphoria after acquired brain injury. ( 25686381 )
2016
46
Effects of anosognosia and neuropsychiatric symptoms on the quality of life of patients with Alzheimer's disease: a 24-month follow-up study. ( 25963296 )
2016
47
Heterogeneity of Cognitive Anosognosia and its Variation with the Severity of Dementia in Patients with Alzheimer's Disease. ( 26638866 )
2016
48
Anosognosia increases caregiver burden in mild cognitive impairment. ( 26643996 )
2016
49
Mentalizing the body: spatial and social cognition in anosognosia for hemiplegia. ( 26811254 )
2016
50
Functional cerebral space theory: Towards an integration of theory and mechanisms of left hemineglect, anosognosia, and anosodiaphoria. ( 26889731 )
2016

Variations for Anosognosia

Expression for Anosognosia

Search GEO for disease gene expression data for Anosognosia.

Pathways for Anosognosia

Pathways related to Anosognosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.98 PLG PSEN2

GO Terms for Anosognosia

Biological processes related to Anosognosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 EP300 PROP1
2 regulation of cholesterol metabolic process GO:0090181 8.96 APOE EPHX2
3 homocysteine metabolic process GO:0050667 8.62 CBSL MTHFR

Sources for Anosognosia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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