MCID: ANV001
MIFTS: 49

Anovulation

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Anovulation

MalaCards integrated aliases for Anovulation:

Name: Anovulation 12 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3781
MeSH 45 D000858
NCIt 51 C34388
SNOMED-CT 69 34571000
UMLS 74 C0003128

Summaries for Anovulation

Disease Ontology : 12 An ovarian disease that is characterized by the absence of ovulation.

MalaCards based summary : Anovulation is related to premenstrual tension and infertility. An important gene associated with Anovulation is SHBG (Sex Hormone Binding Globulin), and among its related pathways/superpathways are Metabolism of proteins and Development Endothelin-1/EDNRA signaling. The drugs Metformin and Sodium Citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, pituitary and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Anovulation is when the ovaries do not release an oocyte during a menstrual cycle. Therefore, ovulation... more...

Related Diseases for Anovulation

Diseases related to Anovulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 premenstrual tension 30.4 GNRH1 PRL SHBG
2 infertility 30.3 CYP19A1 FSHB FSHR GNRH1 PRL
3 polycystic ovary syndrome 30.3 CYP19A1 FSHR GNRH1 IGF1 IGFBP1 INS
4 hyperprolactinemia 30.2 GNRH1 IGF1 PRL SHBG
5 hyperinsulinism 29.5 IGF1 IGFBP1 INS LEP SHBG
6 hyperandrogenism 29.3 CYP19A1 GNRH1 IGF1 IGFBP1 INS PRL
7 diabetes mellitus, noninsulin-dependent 29.3 IGF1 IGFBP1 INS LEP SHBG
8 diabetes mellitus 29.2 IGF1 IGFBP1 INS LEP SHBG
9 endometrial cancer 29.1 CYP19A1 GNRH1 IGF1 IGFBP1 INS SHBG
10 amenorrhea 29.1 BMP15 FSHB FSHR GNRH1 LEP PRL
11 hypothyroidism 29.0 FSHR IGF1 LEP PRL SHBG
12 glucose intolerance 29.0 IGF1 IGFBP1 INS LEP SHBG
13 ovarian disease 28.2 BMP15 CGA CYP19A1 FSHR GNRH1 IGF1
14 resistance to lh 11.2
15 chiasmal syndrome 10.3 GNRH1 PRL
16 hypoactive sexual desire disorder 10.3 CYP19A1 SHBG
17 hypogonadotropism 10.3 GNRH1 PRL
18 seborrheic dermatitis 10.3 CGA SHBG
19 hypothalamic disease 10.3 GNRH1 PRL
20 androgen insensitivity, partial 10.3 CYP19A1 SHBG
21 luteoma 10.3 CGA CYP19A1
22 secondary adrenal insufficiency 10.3 IGF1 INS
23 alopecia, androgenetic, 1 10.3 CYP19A1 SHBG
24 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.3 IGF1 INS
25 pseudovaginal perineoscrotal hypospadias 10.3 CGA GNRH1
26 galactorrhea 10.3 IGF1 PRL
27 pigmentation disease 10.3 INS SHBG
28 marasmus 10.3 IGF1 SHBG
29 fetal erythroblastosis 10.3 INS SHBG
30 pseudohypoparathyroidism, type ia 10.3 IGF1 PRL
31 central precocious puberty 10.3 GNRH1 IGF1
32 hypogonadotropic hypogonadism 23 without anosmia 10.3 FSHR GNRH1
33 tsh producing pituitary tumor 10.2 GNRH1 PRL
34 donohue syndrome 10.2 IGF1 INS
35 pelvic varices 10.2 GNRH1 PRL SHBG
36 endometriosis 10.2
37 precocious puberty, male-limited 10.2 CYP19A1 FSHR
38 pituitary apoplexy 10.2 GNRH1 INS PRL
39 complete androgen insensitivity syndrome 10.2 CGA CYP19A1 SHBG
40 freemartinism 10.2 BMP15 GNRH1
41 type 1 diabetes mellitus 7 10.2 IGFBP1 INS
42 chromophobe adenoma 10.2 GNRH1 INS PRL
43 pituitary-dependent cushing's disease 10.2 GNRH1 INS PRL
44 male reproductive system disease 10.2 GNRH1 IGF1 SHBG
45 sebaceous gland disease 10.2 IGF1 SHBG
46 androgenic alopecia 10.2 CYP19A1 PRL SHBG
47 aromatase deficiency 10.2 CYP19A1 GNRH1 INS
48 breast cancer 10.2
49 male reproductive organ cancer 10.2 GNRH1 IGF1 SHBG
50 diabetes insipidus, neurohypophyseal 10.2 GNRH1 PRL

Graphical network of the top 20 diseases related to Anovulation:



Diseases related to Anovulation

Symptoms & Phenotypes for Anovulation

GenomeRNAi Phenotypes related to Anovulation according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.62 IGF1 LEP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.62 LEP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.62 IGF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.62 IGF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.62 IGF1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.62 IGF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.62 SHBG
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.62 IGF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.62 BMP15
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.62 IGF1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.62 BMP15 IGF1 LEP SHBG
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.62 LEP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.62 IGF1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.62 LEP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.62 IGF1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.62 BMP15

MGI Mouse Phenotypes related to Anovulation:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.2 AMHR2 BMP15 CGA CYP19A1 FSHB FSHR
2 homeostasis/metabolism MP:0005376 10.13 AMHR2 CGA CYP19A1 FSHB FSHR GNRH1
3 cellular MP:0005384 10.08 AMHR2 CYP19A1 FSHB FSHR IGF1 IGFBP1
4 immune system MP:0005387 10.06 AMHR2 CYP19A1 FSHR GNRH1 IGF1 IGFBP1
5 integument MP:0010771 9.97 AMHR2 CYP19A1 FSHR GNRH1 IGF1 INS
6 adipose tissue MP:0005375 9.89 CYP19A1 FSHR IGF1 INS LEP
7 liver/biliary system MP:0005370 9.8 CYP19A1 GNRH1 IGFBP1 INS LEP PRL
8 nervous system MP:0003631 9.76 CGA CYP19A1 FSHR GNRH1 IGF1 INS
9 neoplasm MP:0002006 9.73 AMHR2 FSHR GNRH1 IGF1 LEP PRL
10 renal/urinary system MP:0005367 9.43 AMHR2 CYP19A1 GNRH1 IGF1 INS LEP
11 reproductive system MP:0005389 9.36 AMHR2 BMP15 CGA CYP19A1 FSHB FSHR

Drugs & Therapeutics for Anovulation

Drugs for Anovulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 170)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 657-24-9 14219 4091
2
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 68-04-2
3
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 112809-51-5 3902
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Early Phase 1,Not Applicable 50-28-2 5757
5
Polyestradiol phosphate Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 28014-46-2
6
Ethinyl Estradiol Approved Phase 4,Not Applicable 57-63-6 5991
7
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
8
Zinc Approved, Investigational Phase 4,Early Phase 1 7440-66-6 32051
9
Menotropins Approved Phase 4,Phase 1,Phase 2,Not Applicable 9002-68-0, 61489-71-2 5360545
10
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
11
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Not Applicable 71-58-9
12
leucovorin Approved Phase 4,Not Applicable 58-05-9 143 6006
13
Acetylcysteine Approved, Investigational Phase 4,Not Applicable 616-91-1 12035
14
Drospirenone Approved Phase 4 67392-87-4 68873
15
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
16
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
17
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 77-92-9 311
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
19
Enclomiphene Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15690-57-0
20 Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Estrogen Receptor Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Chelating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Zuclomiphene Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Estrogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Selective Estrogen Receptor Modulators Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Citrate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
33 Fertility Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
35 Clomiphene Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Aromatase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
38 Estradiol 3-benzoate Phase 4,Phase 3,Early Phase 1,Not Applicable
39 Contraceptive Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Estradiol 17 beta-cypionate Phase 4,Phase 3,Early Phase 1,Not Applicable
41 Contraceptive Agents, Male Phase 4,Phase 3,Not Applicable
42
Cyproterone Phase 4 2098-66-0 5284537
43 Androgens Phase 4,Phase 2,Not Applicable,Early Phase 1
44 Contraceptives, Oral Phase 4,Phase 3,Not Applicable
45 Androgen Antagonists Phase 4,Phase 2,Not Applicable
46 Progestins Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
47 Tin Fluorides Phase 4,Phase 3
48 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
49 insulin Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
50 Contraceptives, Oral, Combined Phase 4

Interventional clinical trials:

(show top 50) (show all 168)
# Name Status NCT ID Phase Drugs
1 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4 Clomiphene citrate, metformin, metformin plus clomiphene citrate, gonadotropins
2 Administration of Single High Dose Letrozole for Ovulation Induction Unknown status NCT02703649 Phase 4 Letrozole
3 Concomitant CC and E2 Versus CC Alone in Ovulation Induction Unknown status NCT02186782 Phase 4 Clomiphene citrate and Estradiol;Clomiphene citrate and Placebo
4 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
5 Metformin in Infertile PCOS Patients Unknown status NCT00501904 Phase 4 Metformin
6 PCOS, Therapy and Markers of Cardiovascular Risk Unknown status NCT01798875 Phase 4 oral metformin;oral contraceptive
7 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4 Menopur
8 Treatment of Anovulatory Infertility in PCOS Patients Completed NCT00471523 Phase 4 Clomiphene citrate;Metformin
9 Second-Line Treatments for Anovulatory Infertility in PCOS Patients Completed NCT00558077 Phase 4 Metformin plus clomiphene citrate
10 Structured Exercise Training Program Versus Hypocaloric Hyperproteic Diet in Obese Anovulatory Infertile Patients With PCOS Completed NCT00473538 Phase 4
11 Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction Completed NCT01081626 Phase 4 Recombinant FSH (follitropin alpha)
12 PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene Completed NCT00795808 Phase 4 Metformin;Placebo;Metformin + Clomiphene;Metformin;Clomiphene
13 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4 Medroxyprogesterone acetate
14 Short-term Structured Exercise Training Program Plus Diet Intervention in Patients With Polycystic Ovary Syndrome (PCOS) Completed NCT01004068 Phase 4 Clomiphene citrate
15 Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients Completed NCT00953355 Phase 4 Folate plus metformin;Placebo plus metformin
16 "Stair Step Study" Completed NCT03309176 Phase 4 Medroxyprogesterone Acetate 10 MG
17 N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome Completed NCT02239107 Phase 4 N-Acetyl cysteine
18 Adding L-Carnitine to Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovary Syndrome Completed NCT03630341 Phase 4 Clomiphene Citrate 50mg;L-carnitine;Placebo Oral Tablet
19 The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS Completed NCT02866786 Phase 4 Metformin;ethinyl estradiol and cyproterone acetate
20 Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism Completed NCT01360996 Phase 4 3 mg DRSP/20 μg EE
21 Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. Completed NCT01896492 Phase 4 NAC
22 The Effect of Metformin on Different Hormones in PCOS Patients Completed NCT02568488 Phase 4 Metformin
23 Metformin Suspension and Insulin Sensitivity Completed NCT00437333 Phase 4 Metformin cloridrate
24 Aromatase Inhibitor Effects on Ovarian Function During the Follicular and Early Luteal Phase in Women Completed NCT01046578 Phase 4 Letrozole;Letrozole;Letrozole;Letrozole;Letrozole;Letrozole
25 Letrozole Versus Clomifene Citrate for Ovulation Induction Completed NCT00478504 Phase 4 Letrozole;Clomifene citrate
26 Study on Safety and Efficacy of Levetiracetam in the Adjunctive Treatment of Female Subjects With C1 Catamenial Epilepsy Completed NCT00630630 Phase 4 Levetiracetam
27 Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS Recruiting NCT03252223 Phase 4 Recombinant Follicle Stimulating Hormone
28 Continuous Versus Cyclical OCP Use in PCOS Recruiting NCT03819140 Phase 4 Yasmin
29 Endometrial Thickness and Subendometrial Vascularity in Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin Active, not recruiting NCT03486626 Phase 4 Metformin
30 Controlled Ovarian Stimulation Followed by Timed Intercourse or Intrauterine Insemination in Infertile PCOS Patients Suspended NCT00502281 Phase 4 highly purified urinary FSH
31 Pilot Study:Role of Dietary Fiber in PCOS Anovulation Terminated NCT00703092 Phase 4 Fiber-Stat
32 Low-dose Gonal-f® in Ovulation Induction Terminated NCT01871532 Phase 4 Gonal-f®
33 Metformin in Assisted Reproduction-MET-AR-study Terminated NCT00159575 Phase 4 Metformin / Placebo treatment for 4 months
34 Metformin Administration in Infertile Anovulatory PCOS Patients Withdrawn NCT00501787 Phase 4 Metformin
35 Clomiphene Citrate in Infertile PCOS Patients Withdrawn NCT00501839 Phase 4 clomiphene citrate
36 Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin Withdrawn NCT00502229 Phase 4 Clomiphene citrate, metformin, highly purified urinary FSH
37 The Clinical Trial of Acupuncture Pre-treatment on PCOS Unknown status NCT02491320 Phase 3 Letrozole
38 Phase III Clinical Study of Domestic Recombinant Human Follitropin for Injection to Treat WHO Class II Anovulation Completed NCT02335879 Phase 3
39 Trial to Assess the Clinical Efficacy and Safety of MSJ-0011 in Inducing Ovulation in Anovulatory or Oligo-ovulatory Japanese Women Completed NCT01653743 Phase 3 MSJ-0011;urinary hCG (u-hCG);Follitropin alpha
40 A Phase III Clinical Study to Compare the Efficacy and Safety of DA-3801 and That of Gonal-F® Completed NCT01820728 Phase 3 DA-3801 Injection;Gonal-F®
41 The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women Completed NCT00413179 Phase 3 Metformin;Clomiphene citrate;Placebo
42 Letrozole vs. Clomiphene Citrate in Patients With Anovulatory Infertility Completed NCT00610077 Phase 3 Letrozole;Clomiphene citrate
43 Evaluation of Efficacy and Safety of Highly Purified Urofollitropin for Ovulation Induction in Chinese Females Completed NCT01923194 Phase 3 Highly Purified Urofollitropin;Recombinant Human Follitropin Alfa
44 Traditional Clomiphene Citrate Administration vs. Stair-step Approach Completed NCT01008319 Phase 3 clomiphene citrate;clomiphene citrate
45 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH Completed NCT00296465 Phase 2, Phase 3 Pulsatile gonadotropin-releasing hormone (GnRH);Clomiphene Citrate;Placebo Pulsatile GnRH;Placebo Clomiphene Citrate
46 SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women Completed NCT01185782 Phase 3 Gonalef® (Follitropin alfa);Purified pituitary gonadotropin (Fertinorm-P®)
47 Myo-inositol and Melatonin in Pre-menopausal Women Completed NCT01115127 Phase 2, Phase 3
48 Thermosensitive Gels for the Vaginal Delivery of Sildenafil Citrate Completed NCT02766725 Phase 2, Phase 3 preparation F12 sildenafil in situ gel;preparation F2 sildenafil in situ gel;placebo gel
49 Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS Completed NCT01482286 Phase 3 Metformin
50 Extended Clomiphene Citrate Regimen in Women With Polycystic Ovary Syndrome Completed NCT02381184 Phase 2, Phase 3 clomiphene citrate

Search NIH Clinical Center for Anovulation

Cochrane evidence based reviews: anovulation

Genetic Tests for Anovulation

Anatomical Context for Anovulation

MalaCards organs/tissues related to Anovulation:

42
Ovary, Pituitary, Liver, Breast, Testes, Brain, Bone

Publications for Anovulation

Articles related to Anovulation:

(show top 50) (show all 343)
# Title Authors Year
1
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28544572 )
2018
2
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815914 )
2018
3
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 28815934 )
2018
4
Rates of Anovulation in Adolescents and Young Adults with Moderate to Severe Primary Dysmenorrhea and Those without Primary Dysmenorrhea. ( 29017868 )
2018
5
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 29210151 )
2018
6
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials. ( 29226510 )
2018
7
Gonadotrophins versus clomifene citrate with or without intrauterine insemination in women with normogonadotropic anovulation and clomifene failure (M-OVIN): a randomised, two-by-two factorial trial. ( 29273245 )
2018
8
C-Reactive protein in relation to fecundability and anovulation among eumenorrheic women. ( 29317123 )
2018
9
Altered expression of IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 could contribute to anovulation and follicular persistence in cattle. ( 29334661 )
2018
10
High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice. ( 29535265 )
2018
11
Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menstrual cycles. ( 29673411 )
2018
12
C-type natriuretic peptide: a link between hyperandrogenism and anovulation in a mouse model of polycystic ovary syndrome. ( 29739821 )
2018
13
Lysyl oxidase blockade ameliorates anovulation in polycystic ovary syndrome. ( 30272163 )
2018
14
Oligo-anovulation is not a rarer feature in women with documented endometriosis. ( 30316441 )
2018
15
Gonadotrophins versus clomiphene citrate with or without IUI in women with normogonadotropic anovulation and clomiphene failure: a cost-effectiveness analysis. ( 30576539 )
2018
16
Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation. ( 30773302 )
2018
17
Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial. ( 27754808 )
2017
18
Dairy Food Intake Is Associated with Reproductive Hormones and Sporadic Anovulation among Healthy Premenopausal Women. ( 27881593 )
2017
19
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis. ( 28143834 )
2017
20
Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice. ( 28432106 )
2017
21
Phase III trial comparing the efficacy and safety of recombinant- or urine-derived human chorionic gonadotropin for ovulation triggering in Japanese women diagnosed with anovulation or oligo-ovulation and undergoing ovulation induction with follitropin-alfa. ( 29259450 )
2017
22
Women's perspectives on ovulation induction with or without IUI as treatment for normogonadotrophic anovulation: a discrete choice experiment. ( 30895235 )
2017
23
Role of cortisol and superoxide dismutase in psychological stress induced anovulation. ( 26393311 )
2016
24
Reply: Metformin for women with hyperandrogenic anovulation. ( 26906091 )
2016
25
Metformin for women with hyperandrogenic anovulation. ( 26906093 )
2016
26
Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study. ( 27225433 )
2016
27
Effect of a low glycemic diet in patients with polycystic ovary syndrome and anovulation - a randomized controlled trial. ( 29734548 )
2016
28
Accounting for anovulation and vaginal thinning during depot medroxyprogesterone acetate use. ( 25217405 )
2015
29
Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation. ( 25336505 )
2015
30
Loss of body fat and associated decrease in leptin in early lactation are related to shorter duration of postpartum anovulation in healthy US women. ( 25596410 )
2015
31
Prevalence of conditions causing chronic anovulation and the proposed algorithm for anovulation evaluation. ( 25772812 )
2015
32
Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries. ( 26040673 )
2015
33
Factors associated with nonresponse to ovulation induction using letrozole among women with World Health Organization group II anovulation. ( 26157297 )
2015
34
Non-reproductive Effects of Anovulation: Bone Metabolism in the Luteal Phase of Premenopausal Women Differs between Ovulatory and Anovulatory Cycles. ( 26726266 )
2015
35
Lactational anovulation in mice results from a selective loss of kisspeptin input to GnRH neurons. ( 24169550 )
2014
36
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up. ( 24268702 )
2014
37
Terms and thresholds for the ultrasound evaluation of the ovaries in women with hyperandrogenic anovulation. ( 24516084 )
2014
38
Examining the ovaries by ultrasound for diagnosing hyperandrogenic anovulation: updating the threshold for newer machines. ( 24534278 )
2014
39
Visceral adiposity index (VAI) is related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome. ( 24601936 )
2014
40
Increased androgen, anti-Müllerian hormone, and sporadic anovulation in healthy, eumenorrheic women: a mild PCOS-like phenotype? ( 24606085 )
2014
41
The role of AMH in anovulation associated with PCOS: a hypothesis. ( 24770999 )
2014
42
Assessment of anovulation in eumenorrheic women: comparison of ovulation detection algorithms. ( 24875398 )
2014
43
Individual and combined effects of anovulation and cytological endometritis on the reproductive performance of dairy cows. ( 24996269 )
2014
44
Cost-effectiveness analysis on the use of rFSH + rLH for the treatment of anovulation in hypogonadotropic hypogonadal women. ( 25028553 )
2014
45
Counting ovarian follicles: updated threshold for diagnosis of hyperandrogenic anovulation. ( 25088509 )
2014
46
Willingness to pay for ovulation induction treatment in case of WHO II anovulation: a study using the contingent valuation method. ( 25328385 )
2014
47
Depressive symptoms and their relationship with endogenous reproductive hormones and sporadic anovulation in premenopausal women. ( 25453349 )
2014
48
Loss of LH-induced down-regulation of anti-Müllerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome. ( 23321213 )
2013
49
The influence of sporadic anovulation on hormone levels in ovulatory cycles. ( 23589536 )
2013
50
Clinical review: Adolescent anovulation: maturational mechanisms and implications. ( 23913942 )
2013

Variations for Anovulation

Expression for Anovulation

Search GEO for disease gene expression data for Anovulation.

Pathways for Anovulation

Pathways related to Anovulation according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 CGA FSHB IGF1 IGFBP1 INS LEP
2
Show member pathways
12.37 CGA FSHB GNRH1 IGF1
3
Show member pathways
12.16 CGA INS LEP PRL
4
Show member pathways
11.91 CGA FSHB IGF1 INS LEP
5 11.84 CGA FSHB FSHR
6 11.73 IGF1 INS LEP
7 11.24 INS LEP PRL
8 11.15 CGA CYP19A1 IGF1
9 11.04 CYP19A1 FSHR
10 10.89 FSHB FSHR
11 10.89 CGA CYP19A1 FSHB FSHR
12 10.86 BMP15 CGA CYP19A1 FSHB FSHR IGF1
13 10.83 IGF1 IGFBP1
14 10.71 GNRH1 SHBG
15 10.37 CGA FSHB FSHR GNRH1

GO Terms for Anovulation

Cellular components related to Anovulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 BMP15 CGA FSHB GNRH1 IGF1 IGFBP1
2 extracellular region GO:0005576 9.32 BMP15 CGA FSHB GNRH1 IGF1 IGFBP1
3 endosome lumen GO:0031904 9.26 INS PRL
4 follicle-stimulating hormone complex GO:0016914 9.16 CGA FSHB

Biological processes related to Anovulation according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 CGA FSHB IGF1 INS LEP PRL
2 positive regulation of cell migration GO:0030335 9.81 CGA FSHB IGF1 INS
3 positive regulation of MAPK cascade GO:0043410 9.77 IGF1 INS LEP
4 regulation of multicellular organism growth GO:0040014 9.62 IGF1 PRL
5 positive regulation of mitotic nuclear division GO:0045840 9.62 IGF1 INS
6 female pregnancy GO:0007565 9.62 FSHB GNRH1 LEP PRL
7 positive regulation of JAK-STAT cascade GO:0046427 9.61 LEP PRL
8 peptide hormone processing GO:0016486 9.61 CGA FSHB
9 positive regulation of glycolytic process GO:0045821 9.6 IGF1 INS
10 uterus development GO:0060065 9.58 CYP19A1 FSHR
11 positive regulation of glycogen biosynthetic process GO:0045725 9.58 IGF1 INS
12 female gonad development GO:0008585 9.58 AMHR2 CYP19A1 FSHR
13 positive regulation of insulin receptor signaling pathway GO:0046628 9.57 INS LEP
14 regulation of osteoclast differentiation GO:0045670 9.56 FSHB FSHR
15 response to ethanol GO:0045471 9.55 GNRH1 LEP
16 cellular protein metabolic process GO:0044267 9.55 BMP15 IGF1 IGFBP1 INS PRL
17 gonad development GO:0008406 9.54 CGA FSHR
18 bone mineralization involved in bone maturation GO:0035630 9.49 IGF1 LEP
19 Sertoli cell proliferation GO:0060011 9.48 FSHB FSHR
20 follicle-stimulating hormone signaling pathway GO:0042699 9.46 FSHB FSHR
21 positive regulation of steroid biosynthetic process GO:0010893 9.43 CGA FSHB
22 female gamete generation GO:0007292 9.43 BMP15 FSHB FSHR
23 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 FSHR IGF1 INS LEP
24 regulation of signaling receptor activity GO:0010469 9.23 BMP15 CGA FSHB GNRH1 IGF1 INS
25 ovulation cycle GO:0042698 9.22 GNRH1

Molecular functions related to Anovulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.26 IGF1 INS
2 hormone activity GO:0005179 9.17 CGA FSHB GNRH1 IGF1 INS LEP
3 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 INS
4 follicle-stimulating hormone activity GO:0016913 8.96 CGA FSHB

Sources for Anovulation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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