Aliases & Classifications for Anoxia

MalaCards integrated aliases for Anoxia:

Name: Anoxia 53 71

External Ids:

UMLS 71 C0003130

Summaries for Anoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Anoxia is related to varicocele and cataract, and has symptoms including dyspnea, respiratory distress and cyanosis. An important gene associated with Anoxia is STK25 (Serine/Threonine Kinase 25), and among its related pathways/superpathways are Folate Metabolism and Photodynamic therapy-induced NF-kB survival signaling. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or "low... more...

Related Diseases for Anoxia

Diseases related to Anoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 varicocele 29.4 SOD1 NOS2
2 cataract 28.9 XDH SOD1 ICAM1 AKR1A1
3 vascular disease 28.8 XDH SOD1 NOS2 ICAM1
4 ischemia 28.7 XDH SOD1 NOS2 KCNJ5 ICAM1 ADORA1
5 cerebral hypoxia 11.0
6 acute mountain sickness 11.0
7 hypoxia 10.6
8 papillomatosis, confluent and reticulated 10.5
9 cardiac arrest 10.4
10 hypoglycemia 10.4
11 ocular motor apraxia 10.3
12 encephalopathy 10.2
13 ventricular fibrillation, paroxysmal familial, 1 10.2
14 cerebral palsy 10.2
15 seizure disorder 10.2
16 amnestic disorder 10.2
17 lactic acidosis 10.2
18 cyanosis, transient neonatal 10.1
19 metabolic acidosis 10.1
20 hyperglycemia 10.1
21 48,xyyy 10.1
22 myoclonus 10.1
23 status epilepticus 10.1
24 polycythemia 10.1
25 peyronie disease 10.0 SOD1 NOS2
26 sudden infant death syndrome 10.0
27 yemenite deaf-blind hypopigmentation syndrome 10.0
28 pertussis 10.0
29 brain edema 10.0
30 b-cell lymphoma 10.0
31 neonatal hypoxic and ischemic brain injury 10.0
32 arthus reaction 10.0 NOS2 ICAM1
33 eales disease 10.0 SOD1 NOS2
34 attention deficit-hyperactivity disorder 10.0
35 pulmonary hypertension 10.0
36 basal ganglia calcification 10.0
37 hemiplegia 10.0
38 corneal edema 10.0
39 asphyxia neonatorum 10.0
40 disseminated intravascular coagulation 10.0
41 encephalomalacia 10.0
42 poliomyelitis 10.0
43 cerebrovascular disease 10.0
44 head injury 10.0
45 persistent vegetative state 10.0
46 retinal vasculitis 9.9 SOD1 NOS2
47 mild pre-eclampsia 9.9 XDH SOD1
48 pheochromocytoma 9.9
49 polykaryocytosis inducer 9.9
50 triiodothyronine receptor auxiliary protein 9.9

Graphical network of the top 20 diseases related to Anoxia:



Diseases related to Anoxia

Symptoms & Phenotypes for Anoxia

UMLS symptoms related to Anoxia:


dyspnea, respiratory distress, cyanosis, anoxemia, signs and symptoms, respiratory, labored breathing, symptoms

GenomeRNAi Phenotypes related to Anoxia according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 10.02 ACOX1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.02 ACOX1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.02 AKR1A1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-142 10.02 ACOX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-160 10.02 SIRT2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.02 AKR1A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.02 SIRT2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.02 ACOX1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.02 SIRT2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.02 ACOX1 SIRT2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.02 SIRT2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.02 SIRT2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.02 SIRT2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.02 AKR1A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.02 SIRT2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-34 10.02 SIRT2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-55 10.02 SIRT2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.02 SIRT2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.02 SIRT2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.02 SIRT2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.02 ACOX1 SIRT2
22 shRNA abundance <= 50% GR00343-S 9.1 ADORA1 AKR1A1 ICAM1 KCNJ5 SOD1 STK25

MGI Mouse Phenotypes related to Anoxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ACOX1 AKR1A1 ICAM1 NOS2 SIRT2 SOD1
2 homeostasis/metabolism MP:0005376 9.86 ACOX1 ADORA1 AKR1A1 ICAM1 NOS2 SIRT2
3 endocrine/exocrine gland MP:0005379 9.8 ACOX1 ICAM1 NOS2 SIRT2 SOD1 XDH
4 integument MP:0010771 9.63 ADORA1 ICAM1 NOS2 SIRT2 SOD1 XDH
5 mortality/aging MP:0010768 9.56 ADORA1 AKR1A1 ICAM1 NOS2 SIRT2 SOD1
6 neoplasm MP:0002006 9.02 ACOX1 ICAM1 NOS2 SIRT2 SOD1

Drugs & Therapeutics for Anoxia

Drugs for Anoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a Novel Signal Acquisition Technique for Intrapartum Cardiotocography Unknown status NCT03268486
2 Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation Completed NCT00740220
3 MRI & CT Angiogram and Hyperbaric Oxygen in Chronic Stable Brain Injury Completed NCT01126515
4 Repeated tDCS in Chronic Minimally Conscious State Patients : a Sham-controlled Randomized Double Blind Study Completed NCT02019615
5 Performance Comparison of a New Fetal/Maternal Monitor With an FDA-cleared Method Completed NCT01889316
6 Cerebral Near-infrared Spectroscopy (NIRS) Monitoring Throughout Caesarean Deliveries Completed NCT02473978
7 Accuracy Validation of the Cadwell Pulse Oximetry System Completed NCT02842476
8 Evaluation of Cerebral, Hemodynamic and Neuronal Activities in Neonates in the Immediate Postpartum Not yet recruiting NCT04225975

Search NIH Clinical Center for Anoxia

Genetic Tests for Anoxia

Anatomical Context for Anoxia

MalaCards organs/tissues related to Anoxia:

40
Brain, Endothelial, Cortex, Smooth Muscle, Skeletal Muscle, Cardiac Myocytes, Spinal Cord

Publications for Anoxia

Articles related to Anoxia:

(show top 50) (show all 9511)
# Title Authors PMID Year
1
Exploring pathways of NO and H2S signaling in metabolic depression: The case of anoxic turtles. 61
33276130 2021
2
Causes of early mortality in pediatric trauma patients. 61
33492107 2021
3
Effects of the induction of anoxia in photobioreactor on effective cultivation of Scenedesmus acuminatus under mixotrophic cultivation mode. 61
33475031 2021
4
Response of Anatolian mountain frogs (Rana macrocnemis and Rana holtzi) to freezing, anoxia, and dehydration: Glucose as a cryoprotectant. 61
33285112 2021
5
Effects of Seasonal Anoxia on the Microbial Community Structure in Demosponges in a Marine Lake in Lough Hyne, Ireland. 61
33536324 2021
6
Natural History of Pleural Complications After Lung Transplantation. 61
32853567 2021
7
A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion. 61
33572206 2021
8
Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury. 61
33578393 2021
9
Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway. 61
33546692 2021
10
Freezing stress adaptations: Critical elements to activate Nrf2 related antioxidant defense in liver and skeletal muscle of the freeze tolerant wood frogs. 61
33548505 2021
11
Long-term sustainable phosphorus (P) retention in a low-P stormwater wetland for Everglades restoration. 61
33280863 2021
12
Dexmedetomidine at a dose of 1 µM attenuates H9c2 cardiomyocyte injury under 3 h of hypoxia exposure and 3 h of reoxygenation through the inhibition of endoplasmic reticulum stress. 61
33376514 2021
13
Ca2+ -permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease. 61
33533533 2021
14
A multiwell plate-based system for toxicity screening under multiple static or cycling oxygen environments. 61
33597640 2021
15
In Vivo Transcutaneous Monitoring of Hemoglobin Derivatives Using a Red-Green-Blue Camera-Based Spectral Imaging Technique. 61
33546389 2021
16
The etiology of rhabdomyolysis: an interaction between genetic susceptibility and external triggers. 61
32978841 2021
17
Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles. 61
33387248 2021
18
Hepatotropic Properties of SARS-CoV-2-Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic. 61
33572429 2021
19
A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear. 61
33589396 2021
20
Assessment of National Organ Donation Rates and Organ Procurement Organization Metrics. 61
33263743 2021
21
Tolerance to excess moisture in soybean is enhanced by over-expression of the Glycine max Phytoglobin (GmPgb1). 61
33421908 2021
22
Depth-discrete metagenomics reveals the roles of microbes in biogeochemical cycling in the tropical freshwater Lake Tanganyika. 61
33564113 2021
23
Phosphorus supply pathways and mechanisms in shallow lakes with different regime. 61
33581400 2021
24
Fossil evidence for vampire squid inhabiting oxygen-depleted ocean zones since at least the Oligocene. 61
33603225 2021
25
Variations of sedimentary Fe and Mn fractions under changing lake mixing regimes, oxygenation and land surface processes during Late-glacial and Holocene times. 61
33229087 2021
26
A high-resolution record of Holocene primary productivity and water-column mixing from the varved sediments of Lake Żabińskie, Poland. 61
33229096 2021
27
Modulation of mitochondrial site-specific hydrogen peroxide efflux by exogenous stressors. 61
33383085 2021
28
The anaerobic threshold: 50+ years of controversy. 61
33112439 2021
29
GABA receptor inhibition and severe hypoxia induce a paroxysmal depolarization shift in goldfish neurons. 61
33296606 2021
30
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury. 61
33484825 2021
31
Nicotinamide as a Foundation for Treating Neurodegenerative Disease and Metabolic Disorders. 61
33397266 2021
32
Reduction of anoxia-induced bioenergetic disturbance in astrocytes by methanol fruit extract of Tetrapleura tetraptera and in silico evaluation of the effect of its antioxidative constituents on excitotoxicity. 61
33552925 2021
33
Evaluating the effect of CFH-12® and Phoslock® on phosphorus dynamics during anoxia and resuspension in shallow eutrophic lakes. 61
33280914 2021
34
Upper limits on the extent of seafloor anoxia during the PETM from uranium isotopes. 61
33452243 2021
35
Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming. 61
32949769 2021
36
Pharmacological properties of some mangrove sediment-associated bacillus isolates. 61
32749660 2021
37
Evolution of coding sequence and gene expression of blowflies and botflies with contrasting feeding habits. 61
33022358 2021
38
Enolase2 and enolase1 cooperate against neuronal injury in stroke model. 61
33484738 2021
39
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review. 61
33397238 2021
40
Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway. 61
33220608 2021
41
Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial&nbsp;cells by activating aryl hydrocarbon receptor. 61
33179104 2021
42
River ecosystem resilience risk index: A tool to quantitatively characterize resilience and critical transitions in human-impacted large rivers. 61
33069044 2021
43
Acclimation to warm temperatures has important implications for mitochondrial function in Atlantic salmon (Salmo salar). 61
33288533 2021
44
Rice with SUB1 QTL possesses greater initial leaf gas film thickness leading to delayed perception of submergence stress. 61
32939540 2021
45
Microbial sulfate reduction and organic sulfur formation in sinking marine particles. 61
33335018 2021
46
Disentangling natural vs. anthropogenic induced environmental variability during the Holocene: Marambaia Cove, SW sector of the Sepetiba Bay (SE Brazil). 61
33420935 2021
47
Chronic Oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced GABAergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature. 61
33022295 2021
48
Pgant4 and Tango1 Mediate Anoxia and Reoxygenation Injury. 61
32803622 2020
49
miR-708 affords protective efficacy in anoxia/reoxygenation-stimulated cardiomyocytes by blocking the TLR4 signaling via targeting HMGB1. 61
32866662 2020
50
An Improved HRPE-Based Transcriptional Output Reporter to Detect Hypoxia and Anoxia in Plant Tissue. 61
33287141 2020

Variations for Anoxia

Expression for Anoxia

Search GEO for disease gene expression data for Anoxia.

Pathways for Anoxia

Pathways related to Anoxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.83 XDH SOD1 ICAM1
2
Show member pathways
11.26 NOS2 ICAM1
3
Show member pathways
11.2 SOD1 NOS2
4 11.17 XDH SOD1 NOS2 ACOX1
5 10.97 NOS2 ICAM1
6 10.86 XDH SOD1
7 10.64 NOS2 AKR1A1
8
Show member pathways
10.53 XDH SOD1 NOS2 AKR1A1
9 10.06 XDH NOS2

GO Terms for Anoxia

Cellular components related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.96 NOS2 ACOX1
2 peroxisome GO:0005777 8.92 XDH SOD1 NOS2 ACOX1

Biological processes related to Anoxia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.54 NOS2 ICAM1 ADORA1
2 response to hydrogen peroxide GO:0042542 9.51 STK25 SOD1
3 ovarian follicle development GO:0001541 9.49 SOD1 ICAM1
4 negative regulation of protein catabolic process GO:0042177 9.48 SIRT2 NOS2
5 response to amphetamine GO:0001975 9.46 SOD1 ICAM1
6 negative regulation of blood pressure GO:0045776 9.43 NOS2 ADORA1
7 cell aging GO:0007569 9.4 SOD1 ICAM1
8 superoxide metabolic process GO:0006801 9.32 SOD1 NOS2
9 response to copper ion GO:0046688 9.26 SOD1 ICAM1
10 hydrogen peroxide biosynthetic process GO:0050665 9.16 SOD1 ACOX1
11 oxidation-reduction process GO:0055114 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1
12 relaxation of vascular smooth muscle GO:0060087 8.96 SOD1 ADORA1

Molecular functions related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.56 XDH STK25 NOS2 ACOX1
2 FAD binding GO:0071949 9.16 XDH ACOX1
3 flavin adenine dinucleotide binding GO:0050660 9.13 XDH NOS2 ACOX1
4 oxidoreductase activity GO:0016491 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1

Sources for Anoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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