Aliases & Classifications for Anoxia

MalaCards integrated aliases for Anoxia:

Name: Anoxia 53 71

External Ids:

UMLS 71 C0003130

Summaries for Anoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Anoxia is related to varicocele and ischemia, and has symptoms including dyspnea, respiratory distress and cyanosis. An important gene associated with Anoxia is STK25 (Serine/Threonine Kinase 25), and among its related pathways/superpathways are Folate Metabolism and Photodynamic therapy-induced NF-kB survival signaling. The drugs Fentanyl and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or "low... more...

Related Diseases for Anoxia

Diseases related to Anoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 varicocele 28.9 SOD1 NOS2
2 ischemia 28.8 XDH SOD1 NOS2 KCNJ5 ICAM1
3 cataract 28.7 XDH SOD1 ICAM1 AKR1A1
4 vascular disease 28.5 XDH SOD1 NOS2 ICAM1
5 cerebral hypoxia 11.6
6 acute mountain sickness 11.3
7 hypoxia 10.8
8 papillomatosis, confluent and reticulated 10.6
9 cardiac arrest 10.6
10 hypoglycemia 10.5
11 ocular motor apraxia 10.5
12 encephalopathy 10.4
13 48,xyyy 10.3
14 ventricular fibrillation, paroxysmal familial, 1 10.3
15 cerebral palsy 10.3
16 hydrops, lactic acidosis, and sideroblastic anemia 10.2
17 amnestic disorder 10.2
18 visual epilepsy 10.2
19 lactic acidosis 10.2
20 seizure disorder 10.2
21 cyanosis, transient neonatal 10.2
22 metabolic acidosis 10.2
23 hyperglycemia 10.2
24 myoclonus 10.2
25 status epilepticus 10.1
26 sudden infant death syndrome 10.1
27 yemenite deaf-blind hypopigmentation syndrome 10.1
28 myocardial infarction 10.1
29 pertussis 10.1
30 heart disease 10.1
31 brain edema 10.1
32 polycythemia 10.1
33 neonatal hypoxic and ischemic brain injury 10.1
34 attention deficit-hyperactivity disorder 10.0
35 pulmonary hypertension 10.0
36 basal ganglia calcification 10.0
37 hemiplegia 10.0
38 corneal edema 10.0
39 asphyxia neonatorum 10.0
40 disseminated intravascular coagulation 10.0
41 encephalomalacia 10.0
42 poliomyelitis 10.0
43 b-cell lymphoma 10.0
44 head injury 10.0
45 persistent vegetative state 10.0
46 rapidly involuting congenital hemangioma 10.0
47 colorectal cancer 9.9
48 pheochromocytoma 9.9
49 polykaryocytosis inducer 9.9
50 triiodothyronine receptor auxiliary protein 9.9

Graphical network of the top 20 diseases related to Anoxia:



Diseases related to Anoxia

Symptoms & Phenotypes for Anoxia

UMLS symptoms related to Anoxia:


dyspnea, respiratory distress, cyanosis, anoxemia, signs and symptoms, respiratory, labored breathing, symptoms

GenomeRNAi Phenotypes related to Anoxia according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.98 ACOX1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.98 SIRT2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.98 AKR1A1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.98 ACOX1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.98 SIRT2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.98 SIRT2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-172 9.98 AKR1A1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.98 SIRT2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.98 ACOX1 AKR1A1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.98 SIRT2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.98 ACOX1 AKR1A1 SIRT2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.98 SIRT2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.98 SIRT2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.98 ACOX1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.98 SIRT2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.98 AKR1A1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.98 SIRT2
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.98 SIRT2
19 shRNA abundance <= 50% GR00343-S 9.17 AKR1A1 ICAM1 KCNJ5 NOS2 PMM1 SOD1

MGI Mouse Phenotypes related to Anoxia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 AKR1A1 ICAM1 NOS2 SIRT2 SOD1 STK25
2 endocrine/exocrine gland MP:0005379 9.43 ACOX1 ICAM1 NOS2 SIRT2 SOD1 XDH
3 neoplasm MP:0002006 9.02 ACOX1 ICAM1 NOS2 SIRT2 SOD1

Drugs & Therapeutics for Anoxia

Drugs for Anoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Lorazepam Approved Phase 4 846-49-1 3958
3
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
4
Etomidate Approved Phase 4 33125-97-2 36339 667484
5
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
8
Desflurane Approved Phase 4 57041-67-5 42113
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10 Anesthetics Phase 4
11 Anesthetics, General Phase 4
12 Central Nervous System Depressants Phase 4
13 Anesthetics, Intravenous Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15 Vecuronium Bromide Phase 4 50700-72-6
16 Anesthetics, Inhalation Phase 4
17 Bromides Phase 4
18 Hypnotics and Sedatives Phase 4
19
Thiopental Approved, Vet_approved Phase 3 76-75-5 3000715
20
Pentobarbital Approved, Investigational, Vet_approved Phase 3 76-74-4 4737
21 Neurotransmitter Agents Phase 3
22 Adjuvants, Anesthesia Phase 3
23 GABA Agents Phase 3
24 Anticonvulsants Phase 3
25 GABA Modulators Phase 3
26 Fluorodeoxyglucose F18 Phase 2
27 Fluoroazomycin arabinoside Phase 2
28 Radiopharmaceuticals Phase 2
29
Etanidazole Investigational Phase 1 22668-01-5
30
Ketamine Approved, Vet_approved 6740-88-1 3821
31
Morphine Approved, Investigational 57-27-2 5288826
32 Narcotics
33 Pharmaceutical Solutions
34 Analgesics, Opioid
35 Anesthetics, Dissociative
36 Analgesics
37 Excitatory Amino Acid Antagonists
38 Excitatory Amino Acids

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Influence of Cardiopulmonary Bypass and Sevoflurane or Propofol Anesthesia on Tissue Oxygen Saturation of Thenar Muscle in Adults. Completed NCT02593448 Phase 4
2 To Evaluate the Efficacy and Safety of Xinnaoning Capsule in Treating Chronic Stable Angina Pectoris (Qi Stagnation and Blood Stasis Syndrome) : a Randomized, Double-blind, Parallel Controlled, Multi-center Clinical Study Recruiting NCT03914131 Phase 4 Xinnaoning Capsule
3 Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study Recruiting NCT03729011 Phase 4 Volatile agent;Propofol
4 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
5 A Randomized Clinical Trial for the Treatment of Refractory Status Epilepticus Terminated NCT00265616 Phase 3 propofol;thiopental/pentobarbital
6 Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury Completed NCT00830453 Phase 2
7 A Phase II Pre-Treatment Hypoxia PET Imaging Study Using 18F-FAZA in Patients With Invasive Duct Carcinoma of the Breast Terminated NCT00771381 Phase 2 18F-FAZA PET scan;FluGlucoScan Injection (18F-FDB) PET scan
8 Phase I Trial of EF5, an Agent for the Detection of Hypoxia Completed NCT00003282 Phase 1 EF5
9 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Not yet recruiting NCT03152799 Phase 1
10 Influence of the Administration of Autologous Bone Marrow Mononuclear Cells for the Duration of Functioning Aorto-coronary Bypass Grafts in the Surgical Treatment of Coronary Heart Disease Unknown status NCT02059512
11 Evaluation of a Novel Signal Acquisition Technique for Intrapartum Cardiotocography Unknown status NCT03268486
12 Cardioverter Defibrillator Replacement With Induction of Ventricular Fibrillation and Defibrillation Testing Unknown status NCT02513030
13 Functional Outcome After Cardiac Arrest; Prediction and Prognosis Factors for Patients Awake Within the First 15 Days Completed NCT02292147
14 Selective Bronchial Intubation (SBI) at Marie Lannelongue Hospital (HML) : Epidemiology of Expected and Unexpected Difficult Intubations. Completed NCT03204656
15 Performance Comparison of a New Fetal/Maternal Monitor With an FDA-cleared Method Completed NCT01889316
16 Multimodal Magnetic Resonance (MRI) Development in Comatose Patients for an Algorithm in the Prediction of Consciousness Recovery Completed NCT00577954
17 Pilot Study : Evaluation of a Mandibular and Abdominal Motion Detection Sensors (JAWAC) to Prevent Apnea During Sedation With Propofol in TCI Mode Completed NCT02909309
18 Cerebral Near-infrared Spectroscopy (NIRS) Monitoring Throughout Caesarean Deliveries Completed NCT02473978
19 Repeated tDCS in Chronic Minimally Conscious State Patients : a Sham-controlled Randomized Double Blind Study Completed NCT02019615
20 Establishing 1H Nuclear Magnetic Resonance (NMR) Based Metabonomics Fingerprinting Profile for Severe Poly Trauma Patients Completed NCT01279239
21 Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation Completed NCT00740220
22 The Role of Perioperative Ventilation (Gas Exchange) During Intrabdominal Surgery on Cognitive Function: a Randomized Clinical Study Completed NCT02267031
23 MRI & CT Angiogram and Hyperbaric Oxygen in Chronic Stable Brain Injury Completed NCT01126515
24 Accuracy Validation of the Cadwell Pulse Oximetry System Completed NCT02842476
25 Bone Loss, Fractures, and Management of Bone Health in People With Stroke in Managed Rehabilitation Settings Completed NCT00462683
26 Extracorporeal Membrane Oxygenation and Cerebral Blood Flow Velocity Evaluated by Transcranial Doppler Recruiting NCT03457090
27 The NEUROlogically-impaired Extubation Timing Trial Recruiting NCT02920580
28 Effect of Endotracheal Tube Plus STYLET Versus Endotracheal Tube Alone on Successful First-Pass Orotracheal Intubation Among Critically Ill Patients: the Randomised STYLETO Study Protocol" Recruiting NCT04079387
29 The Home-Use of Semiconducting QUantum Excitonic Device: Image Converter/Sound Converter/Electromagnetic Converter to Improve Communicative Efforts, Speech, Language and Related Cognitive Functions in Children With Autism Recruiting NCT03222375
30 Treatment of Patients With Morphine or/and Ketamine During Out-of-hospital Cardiac Pulmonary Resuscitation Not yet recruiting NCT04009759 Morphine;Ketamine Injectable Solution;Saline 0.9%
31 Pancreatic Islet Transplantation to the Anterior Chamber of the Eye Not yet recruiting NCT04198350

Search NIH Clinical Center for Anoxia

Genetic Tests for Anoxia

Anatomical Context for Anoxia

MalaCards organs/tissues related to Anoxia:

40
Brain, Heart, Liver, Endothelial, Cortex, Lung, Kidney

Publications for Anoxia

Articles related to Anoxia:

(show top 50) (show all 9308)
# Title Authors PMID Year
1
The genus Tragopogon (Asteraceae): A review of its traditional uses, phytochemistry, and pharmacological properties. 61
31837413 2020
2
Lentivirus-mediated microRNA-26a-modified neural stem cells improve brain injury in rats with cerebral palsy. 61
31264214 2020
3
An hypoxia-tolerant flatfish: consequences of sustained stress on the slender sole Lyopsetta exilis (Pleuronectidae) in the context of a changing ocean. 61
31755100 2020
4
Resting stages of sSkeletonema marinoi assimilate nitrogen from the ambient environment under dark, anoxic conditions. 61
32012281 2020
5
Diagnosis of cyanide poisoning using an automated, field-portable sensor for rapid analysis of blood cyanide concentrations. 61
31948575 2020
6
Advances and applications of environmental stress adaptation research. 61
31778815 2020
7
Mathematical predictions of oxygen availability in micro- and macro-encapsulated human and porcine pancreatic islets. 61
31013399 2020
8
Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let‑7a‑5p/IGF2BP3 in cardiomyocytes. 61
31894303 2020
9
Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia. 61
31836416 2020
10
Modulation activity of heat-treated and untreated lactoferrin on the TLR-4 pathway in anoxia cell model and cerebral ischemia reperfusion mouse model. 61
31837800 2020
11
Heart mitochondria from naked mole-rats (Heterocephalus glaber) are more coupled, but similarly susceptible to anoxia-reoxygenation stress than in laboratory mice (Mus musculus). 61
31678269 2020
12
Impaired Vps34 complex activity-mediated autophagy inhibition contributes to endothelial progenitor cells damage in the ischemic conditions. 61
32029275 2020
13
Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation. 61
31999976 2020
14
Hepatocellular HO-1 mediated iNOS-induced hepatoprotection against liver ischemia reperfusion injury. 61
31733834 2020
15
MiR-183-5p protects rat hearts against myocardial ischemia/reperfusion injury through targeting VDAC1. 61
31618500 2020
16
Long non‑coding RNA GAS5 regulates myocardial ischemia‑reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR‑532‑5p. 61
31985016 2020
17
Human umbilical cord mesenchymal stem cells-derived exosomes transfers microRNA-19a to protect cardiomyocytes from acute myocardial infarction by targeting SOX6. 61
31924121 2020
18
The endemic and endangered Maugean Skate (Zearaja maugeana) exhibits short-term severe hypoxia tolerance. 61
31976076 2020
19
Implementation of a monitoring approach: the Palic-Ludas lake system in the Republic of Serbia. 61
31997015 2020
20
Adjusting Tropical Marine Water Quality Guideline Values for Elevated Ocean Temperatures. 61
31845576 2020
21
A novel class of cardioprotective small-molecule PTP inhibitors. 61
31759087 2020
22
Activated carbon stimulates microbial diversity and PAH biodegradation under anaerobic conditions in oil-polluted sediments. 61
32007777 2020
23
Naked Mole-Rats: Blind, Naked, and Feeling No Pain. 61
30365235 2020
24
Anoxia remediation and internal loading modulation in eutrophic lakes using geoengineering method based on oxygen nanobubbles. 61
31982760 2020
25
Photoautotrophic cultures of Chlamydomonas reinhardtii: sulfur deficiency, anoxia, and hydrogen production. 61
31897856 2020
26
Biomechanical properties of the hypoxic and dying brain quantified by magnetic resonance elastography. 61
31726251 2020
27
Is rapid cold-hardening an aerobic process? Characterization of changes in metabolic activity during its induction and effects of anoxia in flesh fly. 61
31837292 2020
28
Anoxia can increase the rate of decay for cnidarian tissue: Using Actinia equina to understand the early fossil record. 61
31990129 2020
29
Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia/reoxygenation injury. 61
31707350 2020
30
Interfacial oxygen nanobubbles reduce methylmercury production ability of sediments in eutrophic waters. 61
31706242 2020
31
Photostability of organic red food dyes. 61
32000082 2020
32
Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs). 61
31882095 2020
33
Expression Analysis of Important Genes Involved in Nitrogen Metabolism Under Hypoxia. 61
31595470 2020
34
Protein Kinase A-Mediated Suppression of the Slow Afterhyperpolarizing KCa3.1 Current in Temporal Lobe Epilepsy. 61
31672789 2019
35
The anti-fatigue and anti-anoxia effects of Tremella extract. 61
31889793 2019
36
Stochastic multicellular modeling of x-ray irradiation, DNA damage induction, DNA free-end misrejoining and cell death. 61
31827107 2019
37
A diverse uncultivated microbial community is responsible for organic matter degradation in the Black Sea sulphidic zone. 61
31858660 2019
38
Brusatol Protects HepG2 Cells against Oxygen-Glucose Deprivation-Induced Injury via Inhibiting Mitochondrial Reactive Oxygen Species-Induced Oxidative Stress. 61
31825932 2019
39
The Impact of Therapeutic Hypothermia Used to Treat Anoxic Brain Injury After Cardiopulmonary Resuscitation on Organ Donation Outcomes. 61
30848704 2019
40
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia. 61
31490091 2019
41
MitosRNAs and extreme anoxia tolerance in embryos of the annual killifish Austrofundulus limnaeus. 61
31874982 2019
42
Neonatal anoxia impairs long-term energy metabolism and somatic development of Wistar rats. 61
31715265 2019
43
Development-specific transcriptomic profiling suggests new mechanisms for anoxic survival in the ventricle of overwintering turtles. 61
31862849 2019
44
Oxygen and brain death; back from the brink. 61
31605408 2019
45
Endothelial cell dysfunction during anoxia-reoxygenation is associated with a decrease in adenosine triphosphate levels, rearrangement in lipid bilayer phosphatidylserine asymmetry, and an increase in endothelial cell permeability. 61
31464867 2019
46
ADHD symptoms induced by prenatal methamphetamine exposure. 61
31928052 2019
47
Subglacial meltwater supported aerobic marine habitats during Snowball Earth. 61
31792178 2019
48
Ca(2+)N It Be Measured? Detection of Extramitochondrial Calcium Movement With High-Resolution FluoRespirometry. 61
31848391 2019
49
The driving mechanisms of the carbon cycle perturbations in the late Pliensbachian (Early Jurassic). 61
31804521 2019
50
Waste water discharge from a large Ni-Zn open cast mine degrades benthic integrity of Lake Nuasjärvi (Finland). 61
31574392 2019

Variations for Anoxia

Expression for Anoxia

Search GEO for disease gene expression data for Anoxia.

Pathways for Anoxia

Pathways related to Anoxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 XDH SOD1 ICAM1
2
Show member pathways
11.26 NOS2 ICAM1
3
Show member pathways
11.2 SOD1 NOS2
4 11.18 XDH SOD1 NOS2 ACOX1
5 10.97 NOS2 ICAM1
6 10.81 XDH SOD1
7 10.64 NOS2 AKR1A1
8
Show member pathways
10.53 XDH SOD1 NOS2 AKR1A1
9 10.06 XDH NOS2

GO Terms for Anoxia

Cellular components related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.96 NOS2 ACOX1
2 peroxisome GO:0005777 8.92 XDH SOD1 NOS2 ACOX1

Biological processes related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hydrogen peroxide GO:0042542 9.43 STK25 SOD1
2 negative regulation of protein catabolic process GO:0042177 9.4 SIRT2 NOS2
3 ovarian follicle development GO:0001541 9.37 SOD1 ICAM1
4 response to amphetamine GO:0001975 9.32 SOD1 ICAM1
5 cell aging GO:0007569 9.26 SOD1 ICAM1
6 superoxide metabolic process GO:0006801 9.16 SOD1 NOS2
7 oxidation-reduction process GO:0055114 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1
8 response to copper ion GO:0046688 8.96 SOD1 ICAM1

Molecular functions related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.56 XDH STK25 SOD1 NOS2
2 FAD binding GO:0071949 9.16 XDH ACOX1
3 flavin adenine dinucleotide binding GO:0050660 9.13 XDH NOS2 ACOX1
4 oxidoreductase activity GO:0016491 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1

Sources for Anoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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