Aliases & Classifications for Anoxia

MalaCards integrated aliases for Anoxia:

Name: Anoxia 54 72

External Ids:

UMLS 72 C0003130

Summaries for Anoxia

NINDS : 54 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Anoxia is related to ischemia and vascular disease, and has symptoms including dyspnea, respiratory distress and cyanosis. An important gene associated with Anoxia is SIRT2 (Sirtuin 2), and among its related pathways/superpathways are Selenium Micronutrient Network and cAMP signaling pathway. The drugs Fentanyl and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 75 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or "low... more...

Related Diseases for Anoxia

Diseases related to Anoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 ischemia 29.2 XDH SOD1 NOS2 ICAM1 ADORA1
2 vascular disease 29.1 XDH SOD1 NOS2
3 cerebral hypoxia 11.6
4 acute mountain sickness 11.3
5 hypoxia 10.8
6 papillomatosis, confluent and reticulated 10.6
7 cardiac arrest 10.6
8 hypoglycemia 10.5
9 ocular motor apraxia 10.5
10 encephalopathy 10.4
11 48,xyyy 10.3
12 ventricular fibrillation, paroxysmal familial, 1 10.3
13 cerebral palsy 10.3
14 hydrops, lactic acidosis, and sideroblastic anemia 10.2
15 amnestic disorder 10.2
16 visual epilepsy 10.2
17 lactic acidosis 10.2
18 seizure disorder 10.2
19 cyanosis, transient neonatal 10.2
20 metabolic acidosis 10.2
21 hyperglycemia 10.2
22 myoclonus 10.2
23 heart disease 10.1
24 status epilepticus 10.1
25 peyronie disease 10.1 SOD1 NOS2
26 retinal vasculitis 10.1 SOD1 NOS2
27 sudden infant death syndrome 10.1
28 yemenite deaf-blind hypopigmentation syndrome 10.1
29 myocardial infarction 10.1
30 pertussis 10.1
31 brain edema 10.1
32 polycythemia 10.1
33 neonatal hypoxic and ischemic brain injury 10.1
34 attention deficit-hyperactivity disorder 10.0
35 pulmonary hypertension 10.0
36 basal ganglia calcification 10.0
37 hemiplegia 10.0
38 corneal edema 10.0
39 asphyxia neonatorum 10.0
40 disseminated intravascular coagulation 10.0
41 encephalomalacia 10.0
42 poliomyelitis 10.0
43 b-cell lymphoma 10.0
44 cataract 10.0
45 head injury 10.0
46 persistent vegetative state 10.0
47 rapidly involuting congenital hemangioma 10.0
48 arthus reaction 10.0 NOS2 ICAM1
49 mild pre-eclampsia 10.0 XDH SOD1
50 colorectal cancer 9.9

Graphical network of the top 20 diseases related to Anoxia:



Diseases related to Anoxia

Symptoms & Phenotypes for Anoxia

UMLS symptoms related to Anoxia:


dyspnea, respiratory distress, cyanosis, anoxemia, signs and symptoms, respiratory, labored breathing, symptoms

MGI Mouse Phenotypes related to Anoxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 ACOX1 EEF2K ICAM1 NOS2 OXTR SIRT2
2 homeostasis/metabolism MP:0005376 9.92 ACOX1 ADORA1 EEF2K ICAM1 NOS2 SIRT2
3 integument MP:0010771 9.8 ADORA1 ICAM1 NOS2 OXTR SIRT2 SOD1
4 muscle MP:0005369 9.55 ICAM1 NOS2 OXTR SOD1 XDH
5 neoplasm MP:0002006 9.35 ACOX1 ICAM1 NOS2 SIRT2 SOD1
6 nervous system MP:0003631 9.17 ADORA1 EEF2K ICAM1 NOS2 OXTR SIRT2

Drugs & Therapeutics for Anoxia

Drugs for Anoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3
Lorazepam Approved Phase 4 846-49-1 3958
4
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
5
Etomidate Approved Phase 4 33125-97-2 36339 667484
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7
Desflurane Approved Phase 4 57041-67-5 42113
8
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10 Central Nervous System Depressants Phase 4
11 Anesthetics, General Phase 4
12 Anesthetics Phase 4
13 Anesthetics, Intravenous Phase 4
14 Neurotransmitter Agents Phase 4
15 Peripheral Nervous System Agents Phase 4
16 Neuromuscular Nondepolarizing Agents Phase 4
17 Neuromuscular Agents Phase 4
18 Cholinergic Agents Phase 4
19 Cholinergic Antagonists Phase 4
20 Neuromuscular Blocking Agents Phase 4
21 Platelet Aggregation Inhibitors Phase 4
22 Vecuronium Bromide Phase 4 50700-72-6
23 Anesthetics, Inhalation Phase 4
24 Bromides Phase 4
25 Hypnotics and Sedatives Phase 4
26
Thiopental Approved, Vet_approved Phase 3 76-75-5 3000715
27
Pentobarbital Approved, Investigational, Vet_approved Phase 3 76-74-4 4737
28 GABA Agents Phase 3
29 Adjuvants, Anesthesia Phase 3
30 GABA Modulators Phase 3
31 Anticonvulsants Phase 3
32 Fluoroazomycin arabinoside Phase 2
33 Radiopharmaceuticals Phase 2
34 Fluorodeoxyglucose F18 Phase 2
35
Etanidazole Investigational Phase 1 22668-01-5
36
Morphine Approved, Investigational 57-27-2 5288826
37
Ketamine Approved, Vet_approved 6740-88-1 3821
38 Pharmaceutical Solutions
39 Narcotics
40 Analgesics
41 Analgesics, Opioid
42 Excitatory Amino Acid Antagonists
43 Anesthetics, Dissociative
44 Excitatory Amino Acids

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Influence of Cardiopulmonary Bypass and Sevoflurane or Propofol Anesthesia on Tissue Oxygen Saturation of Thenar Muscle in Adults. Completed NCT02593448 Phase 4
2 To Evaluate the Efficacy and Safety of Xinnaoning Capsule in Treating Chronic Stable Angina Pectoris (Qi Stagnation and Blood Stasis Syndrome) : a Randomized, Double-blind, Parallel Controlled, Multi-center Clinical Study Recruiting NCT03914131 Phase 4 Xinnaoning Capsule
3 Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study Recruiting NCT03729011 Phase 4 Volatile agent;Propofol
4 Lateral Cord Magnetic Stimulation For Refractory Spastic Cerebral Palsy - Multicenter Double Blind Randomized and Controlled Trial Not yet recruiting NCT03676439 Phase 2, Phase 3
5 A Randomized Clinical Trial for the Treatment of Refractory Status Epilepticus Terminated NCT00265616 Phase 3 propofol;thiopental/pentobarbital
6 Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury Completed NCT00830453 Phase 2
7 A Phase II Pre-Treatment Hypoxia PET Imaging Study Using 18F-FAZA in Patients With Invasive Duct Carcinoma of the Breast Terminated NCT00771381 Phase 2 18F-FAZA PET scan;FluGlucoScan Injection (18F-FDB) PET scan
8 Phase I Trial of EF5, an Agent for the Detection of Hypoxia Completed NCT00003282 Phase 1 EF5
9 Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion (RICE PAC) Study Not yet recruiting NCT03152799 Phase 1
10 Influence of the Administration of Autologous Bone Marrow Mononuclear Cells for the Duration of Functioning Aorto-coronary Bypass Grafts in the Surgical Treatment of Coronary Heart Disease Unknown status NCT02059512
11 Evaluation of a Novel Signal Acquisition Technique for Intrapartum Cardiotocography Unknown status NCT03268486
12 Functional Outcome After Cardiac Arrest; Prediction and Prognosis Factors for Patients Awake Within the First 15 Days Completed NCT02292147
13 Multimodal Magnetic Resonance (MRI) Development in Comatose Patients for an Algorithm in the Prediction of Consciousness Recovery Completed NCT00577954
14 Performance Comparison of a New Fetal/Maternal Monitor With an FDA-cleared Method Completed NCT01889316
15 Selective Bronchial Intubation (SBI) at Marie Lannelongue Hospital (HML) : Epidemiology of Expected and Unexpected Difficult Intubations. Completed NCT03204656
16 Pilot Study : Evaluation of a Mandibular and Abdominal Motion Detection Sensors (JAWAC) to Prevent Apnea During Sedation With Propofol in TCI Mode Completed NCT02909309
17 Cerebral Near-infrared Spectroscopy (NIRS) Monitoring Throughout Caesarean Deliveries Completed NCT02473978
18 Repeated tDCS in Chronic Minimally Conscious State Patients : a Sham-controlled Randomized Double Blind Study Completed NCT02019615
19 Establishing 1H Nuclear Magnetic Resonance (NMR) Based Metabonomics Fingerprinting Profile for Severe Poly Trauma Patients Completed NCT01279239
20 Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation Completed NCT00740220
21 The Role of Perioperative Ventilation (Gas Exchange) During Intrabdominal Surgery on Cognitive Function: a Randomized Clinical Study Completed NCT02267031
22 MRI & CT Angiogram and Hyperbaric Oxygen in Chronic Stable Brain Injury Completed NCT01126515
23 Accuracy Validation of the Cadwell Pulse Oximetry System Completed NCT02842476
24 Bone Loss, Fractures, and Management of Bone Health in People With Stroke in Managed Rehabilitation Settings Completed NCT00462683
25 Extracorporeal Membrane Oxygenation and Cerebral Blood Flow Velocity Evaluated by Transcranial Doppler Recruiting NCT03457090
26 The NEUROlogically-impaired Extubation Timing Trial Recruiting NCT02920580
27 The Home-Use of Semiconducting QUantum Excitonic Device: Image Converter/Sound Converter/Electromagnetic Converter to Improve Communicative Efforts, Speech, Language and Related Cognitive Functions in Children With Autism Recruiting NCT03222375
28 Cardioverter Defibrillator Replacement With Induction of Ventricular Fibrillation and Defibrillation Testing Recruiting NCT02513030
29 Treatment of Patients With Morphine or/and Ketamine During Out-of-hospital Cardiac Pulmonary Resuscitation Not yet recruiting NCT04009759 Morphine;Ketamine Injectable Solution;Saline 0.9%

Search NIH Clinical Center for Anoxia

Genetic Tests for Anoxia

Anatomical Context for Anoxia

MalaCards organs/tissues related to Anoxia:

41
Brain, Heart, Liver, Endothelial, Cortex, Lung, Kidney

Publications for Anoxia

Articles related to Anoxia:

(show top 50) (show all 9225)
# Title Authors PMID Year
1
Thermal conditions during neonatal anoxia affect the endogenous level of brain-derived neurotrophic factor. 38
31257630 2019
2
Initial nitrite concentration promote nitrite-oxidizing bacteria activity recovery from transient anoxia: Experimental and modeling investigations. 38
31323722 2019
3
Thermally coupled dark-anoxia incubation: A platform technology to induce auto-fermentation and thus cell-wall thinning in both nitrogen-replete and nitrogen-deplete Nannochloropsis slurries. 38
31323512 2019
4
Seasonal variation of arsenic and antimony in surface waters of small subarctic lakes impacted by legacy mining pollution near Yellowknife, NT, Canada. 38
31153079 2019
5
NO/cGMP/PKG activation protects Drosophila cells subjected to hypoxic stress. 38
31150868 2019
6
Decreased body temperature during anoxia affects the endogenous BDNF level in tertiary phase of injury. 38
31394123 2019
7
Suppression of root-endogenous fungi in persistently inundated Typha roots. 38
31390954 2019
8
Dual-tracer PET of viable tumor volume and hypoxia for identification of necrosis-containing radio-resistant Sub-volumes. 38
31432722 2019
9
Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtle. 38
31141433 2019
10
A modified calcium retention capacity assay clarifies the roles of extra-and intracellular calcium pools in mitochondrial permeability transition pore opening. 38
31434742 2019
11
Tolerance of roots to low oxygen: 'Anoxic' cores, the phytoglobin-nitric oxide cycle, and energy or oxygen sensing. 38
31255944 2019
12
Diverse role of γ-aminobutyric acid in dynamic plant cell responses. 38
30739138 2019
13
Hypoxia-induced synthesis of respiratory nitrate reductase 2 of Streptomyces coelicolor A3(2) depends on the histidine kinase OsdK in mycelium but not in spores. 38
31259680 2019
14
Paroxysmal Sympathetic Hyperactivity Rate in Vegetative or Minimally Conscious State after Acquired Brain Injury Evaluated by Paroxysmal Sympathetic Hyperactivity Assessment Measure. 38
30887860 2019
15
Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function. 38
31228469 2019
16
Twenty years of the 'Preparation for Oxidative Stress' (POS) theory: Ecophysiological advantages and molecular strategies. 38
30978470 2019
17
Brief oxygenation events in locally anoxic oceans during the Cambrian solves the animal breathing paradox. 38
31406148 2019
18
In defense of proteins: Chaperones respond to freezing, anoxia, or dehydration stress in tissues of freeze tolerant wood frogs. 38
31276323 2019
19
Rapid cold hardening and octopamine modulate chill tolerance in Locusta migratoria. 38
30991118 2019
20
Evidence for the development of local anoxia during the Cambrian SPICE event in eastern North America. 38
30729650 2019
21
Heterogeneous bioapatite carbonation in western painted turtles is unchanged after anoxia. 38
30930203 2019
22
Global marine redox changes drove the rise and fall of the Ediacara biota. 38
31353777 2019
23
Gas chromatographic-sulfur chemiluminescent detector procedures for the simultaneous determination of free forms of volatile sulfur compounds including sulfur dioxide and for the determination of their metal-complexed forms. 38
30837163 2019
24
EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates. 38
31029679 2019
25
Lentivirus-mediated microRNA-26a-modified neural stem cells improve brain injury in rats with cerebral palsy. 38
31264214 2019
26
Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster. 38
31311780 2019
27
FDX5 deletion affects metabolism of algae during the different phases of S-deprivation. 38
31350361 2019
28
Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors. 38
31295864 2019
29
Metabolomics of anoxia tolerance in D. melanogaster: evidence against substrate limitation and for roles of protective metabolites and paralytic hypometabolism. 38
31322917 2019
30
The complete mitochondrial genome of Dryophytes versicolor: Phylogenetic relationship among Hylidae and mitochondrial protein-coding gene expression in response to freezing and anoxia. 38
30936008 2019
31
Experimental evolution of response to anoxia in Drosophilamelanogaster: recovery of locomotion following CO2 or N2 exposure. 38
31285245 2019
32
The role of aquaporin-4 and transient receptor potential vaniloid isoform 4 channels in the development of cytotoxic edema and associated extracellular diffusion parameter changes. 38
30633415 2019
33
A Standardized Care Pathway following Mandibular Distraction in Infants Less Than 3 Months of Age. 38
31331240 2019
34
Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors. 38
30994640 2019
35
Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles ( Chelydra serpentina). 38
31238852 2019
36
Shallow plant-dominated lakes - extreme environmental variability, carbon cycling and ecological species challenges. 38
31189010 2019
37
Metabolic versatility in a modern lineage of cyanobacteria from terrestrial hot springs. 38
31163257 2019
38
Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepod Tigriopus californicus. 38
31182611 2019
39
Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway. 38
31201434 2019
40
Impact of fertiliser, water table, and warming on celery yield and CO2 and CH4 emissions from fenland agricultural peat. 38
30826678 2019
41
Root-zone hypoxia reduces growth of the tropical forage grass Urochloa humidicola in high-nutrient but not low-nutrient conditions. 38
31152584 2019
42
Antioxidant capacity and anoxia tolerance in Austrofundulus limnaeus embryos. 38
31160427 2019
43
The expression of genes involved in excitatory and inhibitory neurotransmission in turtle (Trachemys scripta) brain during anoxic submergence at 21 °C and 5 °C reveals the importance of cold as a preparatory cue for anoxia survival. 38
30780100 2019
44
Bacterial fermentation and respiration processes are uncoupled in anoxic permeable sediments. 38
30858573 2019
45
Deepwater ocean outfalls: A sustainable solution for sewage discharge for mega-coastal cities (Sydney, Australia): Influence of deepwater ocean outfalls on shelf benthic infauna. 38
31256853 2019
46
Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles. 38
31109970 2019
47
Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. 38
31105007 2019
48
Loss of fixed nitrogen causes net oxygen gain in a warmer future ocean. 38
31243270 2019
49
Symbiosis, Selection and Novelty: Freshwater Adaptation in the Unique Sponges of Lake Baikal. 38
31236592 2019
50
Possible links between extreme oxygen perturbations and the Cambrian radiation of animals. 38
31178922 2019

Variations for Anoxia

Expression for Anoxia

Search GEO for disease gene expression data for Anoxia.

Pathways for Anoxia

GO Terms for Anoxia

Cellular components related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.56 SOD1 SIRT2 OXTR NOS2 KCNJ5 ICAM1
2 peroxisomal matrix GO:0005782 9.16 NOS2 ACOX1
3 peroxisome GO:0005777 8.92 XDH SOD1 NOS2 ACOX1

Biological processes related to Anoxia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 XDH SOD1 NOS2 ACOX1
2 response to drug GO:0042493 9.72 SOD1 OXTR ICAM1
3 negative regulation of apoptotic process GO:0043066 9.58 SOD1 EEF2K ADORA1
4 protein targeting to peroxisome GO:0006625 9.57 NOS2 ACOX1
5 positive regulation of synapse assembly GO:0051965 9.56 OXTR EEF2K
6 lactation GO:0007595 9.54 XDH OXTR
7 response to hypoxia GO:0001666 9.54 NOS2 ICAM1 ADORA1
8 ovarian follicle development GO:0001541 9.51 SOD1 ICAM1
9 negative regulation of protein catabolic process GO:0042177 9.49 SIRT2 NOS2
10 positive regulation of vasoconstriction GO:0045907 9.48 OXTR ICAM1
11 negative regulation of blood pressure GO:0045776 9.46 NOS2 ADORA1
12 cell aging GO:0007569 9.43 SOD1 ICAM1
13 superoxide metabolic process GO:0006801 9.32 SOD1 NOS2
14 positive regulation of blood pressure GO:0045777 9.26 OXTR ADORA1
15 response to copper ion GO:0046688 9.16 SOD1 ICAM1
16 relaxation of vascular smooth muscle GO:0060087 8.96 SOD1 ADORA1
17 response to amphetamine GO:0001975 8.8 SOD1 OXTR ICAM1

Molecular functions related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.26 XDH SOD1 NOS2 ACOX1
2 FAD binding GO:0071949 9.16 XDH ACOX1
3 flavin adenine dinucleotide binding GO:0050660 8.8 XDH NOS2 ACOX1

Sources for Anoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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