Aliases & Classifications for Anoxia

MalaCards integrated aliases for Anoxia:

Name: Anoxia 53 70

External Ids:

UMLS 70 C0003130

Summaries for Anoxia

NINDS : 53 Cerebral hypoxia refers to a condition in which there is a decrease of oxygen supply to the brain even though there is adequate blood flow. Drowning, strangling, choking, suffocation, cardiac arrest, head trauma, carbon monoxide poisoning, and complications of general anesthesia can create conditions that can lead to cerebral hypoxia. Symptoms of mild cerebral hypoxia include inattentiveness, poor judgment, memory loss, and a decrease in motor coordination. Brain cells are extremely sensitive to oxygen deprivation and can begin to die within five minutes after oxygen supply has been cut off. When hypoxia lasts for longer periods of time, it can cause coma, seizures, and even brain death.  In brain death, there is no measurable activity in the brain, although cardiovascular function is preserved. Life support is required for respiration.

MalaCards based summary : Anoxia is related to varicocele and cataract, and has symptoms including dyspnea, respiratory distress and cyanosis. An important gene associated with Anoxia is STK25 (Serine/Threonine Kinase 25), and among its related pathways/superpathways are Folate Metabolism and Photodynamic therapy-induced NF-kB survival signaling. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and cortex, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 The term anoxia means a total depletion in the level of oxygen, an extreme form of hypoxia or "low... more...

Related Diseases for Anoxia

Diseases related to Anoxia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 varicocele 29.3 SOD1 NOS2
2 cataract 28.7 XDH SOD1 ICAM1 AKR1A1
3 vascular disease 28.5 XDH SOD1 NOS2 ICAM1
4 ischemia 28.4 XDH SOD1 NOS2 KCNJ5 ICAM1 ADORA1
5 cerebral hypoxia 11.0
6 acute mountain sickness 11.0
7 hypoxia 10.6
8 papillomatosis, confluent and reticulated 10.5
9 cardiac arrest 10.4
10 hypoglycemia 10.4
11 ocular motor apraxia 10.3
12 encephalopathy 10.2
13 ventricular fibrillation, paroxysmal familial, 1 10.2
14 cerebral palsy 10.2
15 seizure disorder 10.2
16 amnestic disorder 10.2
17 lactic acidosis 10.2
18 cyanosis, transient neonatal 10.1
19 metabolic acidosis 10.1
20 hyperglycemia 10.1
21 48,xyyy 10.1
22 myoclonus 10.1
23 status epilepticus 10.1
24 polycythemia 10.1
25 sudden infant death syndrome 10.0
26 yemenite deaf-blind hypopigmentation syndrome 10.0
27 pertussis 10.0
28 brain edema 10.0
29 b-cell lymphoma 10.0
30 neonatal hypoxic and ischemic brain injury 10.0
31 peyronie disease 10.0 SOD1 NOS2
32 attention deficit-hyperactivity disorder 10.0
33 pulmonary hypertension 10.0
34 basal ganglia calcification 10.0
35 hemiplegia 10.0
36 corneal edema 10.0
37 asphyxia neonatorum 10.0
38 disseminated intravascular coagulation 10.0
39 heart disease 10.0
40 encephalomalacia 10.0
41 poliomyelitis 10.0
42 cerebrovascular disease 10.0
43 head injury 10.0
44 persistent vegetative state 10.0
45 arthus reaction 9.9 NOS2 ICAM1
46 eales disease 9.9 SOD1 NOS2
47 retinal vasculitis 9.9 SOD1 NOS2
48 pheochromocytoma 9.9
49 polykaryocytosis inducer 9.9
50 triiodothyronine receptor auxiliary protein 9.9

Graphical network of the top 20 diseases related to Anoxia:



Diseases related to Anoxia

Symptoms & Phenotypes for Anoxia

UMLS symptoms related to Anoxia:


dyspnea; respiratory distress; cyanosis; anoxemia; signs and symptoms, respiratory; labored breathing; symptoms

GenomeRNAi Phenotypes related to Anoxia according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 10.02 ACOX1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.02 ACOX1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.02 AKR1A1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-142 10.02 ACOX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-160 10.02 SIRT2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.02 AKR1A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-173 10.02 SIRT2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.02 ACOX1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.02 SIRT2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.02 ACOX1 SIRT2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-197 10.02 SIRT2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.02 SIRT2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.02 SIRT2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.02 AKR1A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.02 SIRT2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-34 10.02 SIRT2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-55 10.02 SIRT2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.02 SIRT2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.02 SIRT2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.02 SIRT2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-92 10.02 ACOX1 SIRT2
22 shRNA abundance <= 50% GR00343-S 9.1 ADORA1 AKR1A1 ICAM1 KCNJ5 SOD1 STK25

MGI Mouse Phenotypes related to Anoxia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 ACOX1 AKR1A1 ICAM1 NOS2 SIRT2 SOD1
2 homeostasis/metabolism MP:0005376 9.86 ACOX1 ADORA1 AKR1A1 ICAM1 NOS2 SIRT2
3 endocrine/exocrine gland MP:0005379 9.8 ACOX1 ICAM1 NOS2 SIRT2 SOD1 XDH
4 integument MP:0010771 9.63 ADORA1 ICAM1 NOS2 SIRT2 SOD1 XDH
5 mortality/aging MP:0010768 9.56 ADORA1 AKR1A1 ICAM1 NOS2 SIRT2 SOD1
6 neoplasm MP:0002006 9.02 ACOX1 ICAM1 NOS2 SIRT2 SOD1

Drugs & Therapeutics for Anoxia

Drugs for Anoxia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a Novel Signal Acquisition Technique for Intrapartum Cardiotocography Unknown status NCT03268486
2 MRI & CT Angiogram and Hyperbaric Oxygen in Chronic Stable Brain Injury Completed NCT01126515
3 Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation Completed NCT00740220
4 Performance Comparison of a New Fetal/Maternal Monitor With an FDA-cleared Method Completed NCT01889316
5 Accuracy Validation of the Cadwell Pulse Oximetry System Completed NCT02842476
6 Cerebral Near-infrared Spectroscopy (NIRS) Monitoring Throughout Caesarean Deliveries Completed NCT02473978
7 Repeated tDCS in Chronic Minimally Conscious State Patients : a Sham-controlled Randomized Double Blind Study Completed NCT02019615
8 Evaluation of Cerebral, Hemodynamic and Neuronal Activities in Neonates in the Immediate Postpartum Not yet recruiting NCT04225975

Search NIH Clinical Center for Anoxia

Genetic Tests for Anoxia

Anatomical Context for Anoxia

MalaCards organs/tissues related to Anoxia:

40
Brain, Endothelial, Cortex, Smooth Muscle, Skeletal Muscle, Cardiac Myocytes, Spinal Cord

Publications for Anoxia

Articles related to Anoxia:

(show top 50) (show all 9567)
# Title Authors PMID Year
1
New insights into physiological effects of anoxia under darkness on the iconic seagrass Zostera marina based on a combined analysis of transcriptomics and metabolomics. 61
33736305 2021
2
The efficacy of Phoslock® in reducing internal phosphate loading varies with bottom water oxygenation. 61
33763640 2021
3
Human health risk from consumption of aquatic species in arsenic-contaminated shallow urban lakes. 61
33736365 2021
4
Ex vivo evaluation of the biventricular cardiac function for donation after circulatory death model: An experimental study. 61
33001457 2021
5
Management of temperature control in post-cardiac arrest care: an expert report. 61
32703653 2021
6
Observation of dose dependent intravaginal Prostaglandin E2 application in free farrowing sows during parturition - a pilot study. 61
33810812 2021
7
Phosphorus supply pathways and mechanisms in shallow lakes with different regime. 61
33581400 2021
8
Implication of O2 dynamics for both N2O and CH4 emissions from soil during biological soil disinfestation. 61
33758268 2021
9
The Invention of Hypoxia. 61
33703942 2021
10
Photolytic radical persistence due to anoxia in viscous aerosol particles. 61
33741973 2021
11
Impact of neonatal anoxia and hypothermic treatment on development and memory of rats. 61
33713657 2021
12
Nrf2 activates antioxidant enzymes in the anoxia-tolerant red-eared slider turtle, Trachemys scripta elegans. 61
33773070 2021
13
CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls. 61
33656270 2021
14
Exploring pathways of NO and H2S signaling in metabolic depression: The case of anoxic turtles. 61
33276130 2021
15
VDAC1 promotes cardiomyocyte autophagy in anoxia/reoxygenation injury via the PINK1/Parkin pathway. 61
33675282 2021
16
Pharmacological Pre- and Postconditioning With Levosimendan Protect H9c2 Cardiomyoblasts From Anoxia/Reoxygenation-induced Cell Death via PI3K/Akt Signaling. 61
33662980 2021
17
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury. 61
33484825 2021
18
Renal Warm Ischemia in Organ Donors After Circulatory Death. 61
32799784 2021
19
[Prognostic implications of stone heart syndrome in cardiac arrest]. 61
32803299 2021
20
Impact of physical processes on oxygen loss and production of hydrogen sulphide and methane in a tropical freshwater reservoir. 61
33761073 2021
21
Not all patients with convulsive status epilepticus intubated in pre-hospital settings meet the criteria for refractory status epilepticus. 61
33799137 2021
22
Enolase2 and enolase1 cooperate against neuronal injury in stroke model. 61
33484738 2021
23
miR-146a inhibits mitochondrial dysfunction and myocardial infarction by targeting cyclophilin D. 61
33717647 2021
24
Tumor Microenvironment-Activatable Cyclic Cascade Reaction to Reinforce Multimodal Combination Therapy by Destroying the Extracellular Matrix. 61
33720684 2021
25
Greenhouse gas emissions (CO2 and CH4) and inorganic carbon behavior in an urban highly polluted tropical coastal lagoon (SE, Brazil). 61
33723789 2021
26
Causes of early mortality in pediatric trauma patients. 61
33492107 2021
27
Different triggers for the two pulses of mass extinction across the Permian and Triassic boundary. 61
33758284 2021
28
Revisiting the concept of 'enzymic latch' on carbon in peatlands. 61
33744584 2021
29
GABA receptor inhibition and severe hypoxia induce a paroxysmal depolarization shift in goldfish neurons. 61
33296606 2021
30
Variations of sedimentary Fe and Mn fractions under changing lake mixing regimes, oxygenation and land surface processes during Late-glacial and Holocene times. 61
33229087 2021
31
A high-resolution record of Holocene primary productivity and water-column mixing from the varved sediments of Lake Żabińskie, Poland. 61
33229096 2021
32
Modulation of mitochondrial site-specific hydrogen peroxide efflux by exogenous stressors. 61
33383085 2021
33
Low-oxygen hormetic conditioning improves field performance of sterile insects by inducing beneficial plasticity. 61
33664795 2021
34
Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury. 61
33578393 2021
35
A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion. 61
33572206 2021
36
Overexpression of SP1 restores autophagy to alleviate acute renal injury induced by ischemia-reperfusion through the miR-205/PTEN/Akt pathway. 61
33546692 2021
37
Natural History of Pleural Complications After Lung Transplantation. 61
32853567 2021
38
Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat. 61
33639200 2021
39
Freezing stress adaptations: Critical elements to activate Nrf2 related antioxidant defense in liver and skeletal muscle of the freeze tolerant wood frogs. 61
33548505 2021
40
Effects of Seasonal Anoxia on the Microbial Community Structure in Demosponges in a Marine Lake in Lough Hyne, Ireland. 61
33536324 2021
41
Effects of the induction of anoxia in photobioreactor on effective cultivation of Scenedesmus acuminatus under mixotrophic cultivation mode. 61
33475031 2021
42
Response of Anatolian mountain frogs (Rana macrocnemis and Rana holtzi) to freezing, anoxia, and dehydration: Glucose as a cryoprotectant. 61
33285112 2021
43
Tolerance to excess moisture in soybean is enhanced by over-expression of the Glycine max Phytoglobin (GmPgb1). 61
33421908 2021
44
Fossil evidence for vampire squid inhabiting oxygen-depleted ocean zones since at least the Oligocene. 61
33603225 2021
45
Dexmedetomidine at a dose of 1 µM attenuates H9c2 cardiomyocyte injury under 3 h of hypoxia exposure and 3 h of reoxygenation through the inhibition of endoplasmic reticulum stress. 61
33376514 2021
46
Ca2+ -permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease. 61
33533533 2021
47
Hepatotropic Properties of SARS-CoV-2-Preliminary Results of Cross-Sectional Observational Study from the First Wave COVID-19 Pandemic. 61
33572429 2021
48
In Vivo Transcutaneous Monitoring of Hemoglobin Derivatives Using a Red-Green-Blue Camera-Based Spectral Imaging Technique. 61
33546389 2021
49
The etiology of rhabdomyolysis: an interaction between genetic susceptibility and external triggers. 61
32978841 2021
50
Oxidative Damage? Not a Problem! The Characterization of Humanin-like Mitochondrial Peptide in Anoxia Tolerant Freshwater Turtles. 61
33387248 2021

Variations for Anoxia

Expression for Anoxia

Search GEO for disease gene expression data for Anoxia.

Pathways for Anoxia

Pathways related to Anoxia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 XDH SOD1 ICAM1
2
Show member pathways
11.26 NOS2 ICAM1
3
Show member pathways
11.2 SOD1 NOS2
4 11.17 XDH SOD1 NOS2 ACOX1
5 10.97 NOS2 ICAM1
6 10.81 XDH SOD1
7 10.64 NOS2 AKR1A1
8
Show member pathways
10.53 XDH SOD1 NOS2 AKR1A1
9 10.06 XDH NOS2

GO Terms for Anoxia

Cellular components related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.96 NOS2 ACOX1
2 peroxisome GO:0005777 8.92 XDH SOD1 NOS2 ACOX1

Biological processes related to Anoxia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.54 NOS2 ICAM1 ADORA1
2 response to hydrogen peroxide GO:0042542 9.51 STK25 SOD1
3 ovarian follicle development GO:0001541 9.49 SOD1 ICAM1
4 negative regulation of protein catabolic process GO:0042177 9.48 SIRT2 NOS2
5 response to amphetamine GO:0001975 9.46 SOD1 ICAM1
6 negative regulation of blood pressure GO:0045776 9.43 NOS2 ADORA1
7 cell aging GO:0007569 9.4 SOD1 ICAM1
8 superoxide metabolic process GO:0006801 9.32 SOD1 NOS2
9 response to copper ion GO:0046688 9.26 SOD1 ICAM1
10 hydrogen peroxide biosynthetic process GO:0050665 9.16 SOD1 ACOX1
11 oxidation-reduction process GO:0055114 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1
12 relaxation of vascular smooth muscle GO:0060087 8.96 SOD1 ADORA1

Molecular functions related to Anoxia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.56 XDH STK25 NOS2 ACOX1
2 FAD binding GO:0071949 9.16 XDH ACOX1
3 flavin adenine dinucleotide binding GO:0050660 9.13 XDH NOS2 ACOX1
4 oxidoreductase activity GO:0016491 9.02 XDH SOD1 NOS2 AKR1A1 ACOX1

Sources for Anoxia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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