MCID: ANT004
MIFTS: 36

Anterior Cerebral Artery Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Anterior Cerebral Artery Infarction

MalaCards integrated aliases for Anterior Cerebral Artery Infarction:

Name: Anterior Cerebral Artery Infarction 12 15 17
Infarction, Anterior Cerebral Artery 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3528
MeSH 44 D020243
UMLS 70 C0751843

Summaries for Anterior Cerebral Artery Infarction

MalaCards based summary : Anterior Cerebral Artery Infarction, also known as infarction, anterior cerebral artery, is related to carotid artery occlusion and basal ganglia cerebrovascular disease. An important gene associated with Anterior Cerebral Artery Infarction is AGXT (Alanine--Glyoxylate And Serine--Pyruvate Aminotransferase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Neuroscience. The drugs Anticholesteremic Agents and Rosuvastatin Calcium have been mentioned in the context of this disorder. Affiliated tissues include heart, pituitary and bone marrow, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Anterior Cerebral Artery Infarction

Diseases in the Anterior Cerebral Artery Infarction family:

Posterior Cerebral Artery Infarction

Diseases related to Anterior Cerebral Artery Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 carotid artery occlusion 30.3 RBFOX3 PLG PLAT
2 basal ganglia cerebrovascular disease 10.3 PLG PLAT
3 ligneous conjunctivitis 10.3 PLG PLAT
4 basilar artery insufficiency 10.3 PLG PLAT
5 brain stem infarction 10.3 PLG PLAT
6 vertebral artery occlusion 10.3 PLG PLAT
7 inferior myocardial infarction 10.3 PLG PLAT
8 plasminogen deficiency, type i 10.3 PLG PLAT
9 conversion disorder 10.3 PLG PLAT
10 chronic pain 10.3 P2RX4 P2RX3
11 anterior spinal artery syndrome 10.3 PLG F2
12 perforated corneal ulcer 10.3 PLG PLAT
13 aphasia 10.3
14 kidney cortex necrosis 10.3 PLG F2
15 hemopericardium 10.3 PLG F2
16 hereditary angioedema with normal c1inh 10.3 PLG PLAT
17 middle cerebral artery infarction 10.2 PLG PLAT
18 femoral neuropathy 10.2 PLAT F2
19 myocardial infarction 2 10.2 PLAT AVP
20 occlusion precerebral artery 10.2 RBFOX3 PLG PLAT
21 pleural empyema 10.2 PLG F2
22 apraxia 10.2
23 mutism 10.2
24 akinetic mutism 10.2
25 dystonia 10.2
26 alien hand syndrome 10.2
27 supine hypotensive syndrome 10.1 F2 AVP
28 cerebral falx meningioma 10.1 PLG PLAT F2
29 basilar artery occlusion 10.1 PLG PLAT F2
30 acute pulmonary heart disease 10.1 PLG PLAT F2
31 acute cor pulmonale 10.1 PLG PLAT F2
32 subleukemic leukemia 10.1 RBFOX3 AVP
33 cardiac tamponade 10.1 PLG PLAT F2
34 paralytic ileus 10.1 F2 AVP
35 chromophobe adenoma 10.1 PRL AVP
36 pituitary infarct 10.1 PRL AVP
37 intracranial berry aneurysm 10.1 PLG PLAT AVP
38 benign essential hypertension 10.1 PRL AVP
39 sheehan syndrome 10.0 PRL AVP
40 hypothalamic disease 10.0 PRL AVP
41 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 10.0 TH RBFOX3 P2RX4
42 spasmodic dystonia 10.0
43 parkinsonism 10.0
44 facial paralysis 10.0
45 carotid artery disease 10.0
46 cerebrovascular disease 10.0
47 nervous system disease 10.0
48 subacute delirium 10.0
49 spasmodic dysphonia 10.0
50 aneurysm 10.0

Graphical network of the top 20 diseases related to Anterior Cerebral Artery Infarction:



Diseases related to Anterior Cerebral Artery Infarction

Symptoms & Phenotypes for Anterior Cerebral Artery Infarction

MGI Mouse Phenotypes related to Anterior Cerebral Artery Infarction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 AGXT AVP F2 KITLG P2RX3 P2RX4
2 cardiovascular system MP:0005385 10.02 F2 IGFBP2 KITLG P2RX3 P2RX4 PLAT
3 immune system MP:0005387 9.93 AVP CSF3R EEF1A2 F2 IGFBP2 KITLG
4 nervous system MP:0003631 9.7 AVP EEF1A2 F2 KITLG P2RX3 P2RX4
5 renal/urinary system MP:0005367 9.17 AGXT AVP IGFBP2 P2RX4 PLG SERPINC1

Drugs & Therapeutics for Anterior Cerebral Artery Infarction

Drugs for Anterior Cerebral Artery Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticholesteremic Agents Phase 4
2 Rosuvastatin Calcium Phase 4 147098-20-2
3 Antimetabolites Phase 4
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
5 Hypolipidemic Agents Phase 4
6 Lipid Regulating Agents Phase 4
7 Calcium, Dietary Phase 4
8
Calcium Nutraceutical Phase 4 7440-70-2 271
9
Ginseng Approved, Investigational, Nutraceutical 50647-08-0
10 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients Unknown status NCT02484027 Phase 4 Rosuvastatin
2 Intravenous Autologous Bone Marrow-derived Stem Cells Therapy for Patients With Acute Ischemic Stroke: A Multi-Institutional Project Completed NCT02425670 Phase 2
3 Effect of Different Transplantation Time for Human Umbilical Cord Mesenchymal Stem Cells(MSCs) on Prognosis of Acute Cerebral Infarction Patients Enrolling by invitation NCT04093336 Phase 1, Phase 2
4 A Non-interventional, Controlled, Open-label, Observational Registry Study to Investigate the Safety and Effectiveness of LUOTAI (Panax Notoginseng) Injectable and Soft Capsules in Patients With Acute Ischemic Stroke in Vietnam Completed NCT03679364

Search NIH Clinical Center for Anterior Cerebral Artery Infarction

Cochrane evidence based reviews: infarction, anterior cerebral artery

Genetic Tests for Anterior Cerebral Artery Infarction

Anatomical Context for Anterior Cerebral Artery Infarction

MalaCards organs/tissues related to Anterior Cerebral Artery Infarction:

40
Heart, Pituitary, Bone Marrow, Cortex, Parietal Lobe, Bone, Brain

Publications for Anterior Cerebral Artery Infarction

Articles related to Anterior Cerebral Artery Infarction:

(show all 37)
# Title Authors PMID Year
1
Bilateral anterior cerebral artery infarction presenting with acute paraparesis and parkinsonism. 61
32042488 2019
2
Transient Left Alien Hand Syndrome after Left Anterior Cerebral Artery Infarction. 61
30692774 2019
3
Alien hand syndrome and migraine with aura: A case report. 61
29504481 2018
4
Rare etiology for splenium of corpus callosum infarction: Anterior cerebral artery dissecting aneurysm. 61
30177529 2018
5
Herniation despite Decompressive Hemicraniectomy in Large Hemispherical Ischemic Strokes. 61
29107638 2018
6
Frequent neck massage leading to bilateral anterior cerebral artery infarction. 61
29103012 2017
7
Akinetic mutism reversibility after L-dopa therapy in unilateral left anterior cerebral artery infarction. 61
28447507 2017
8
Confined anterior cerebral artery infarction manifesting as isolated unilateral axial weakness. 61
28131184 2017
9
Asterixis in the leg induced by anterior cerebral artery infarction. 61
26803758 2016
10
Erectile dysfunction (ED) after ischemic stroke: association between prevalence and site of lesion. 61
26374302 2015
11
On clipping of anterior communicating artery aneurysm via eyebrow-lateral keyhole approach. 61
26885043 2015
12
Nonfluent aphasia and cognitive impairment caused by anterior cerebral artery infarction. 61
24165417 2013
13
Acute loss of bladder control in a stroke of the frontal cortex. 61
23983877 2012
14
Crossed transcortical motor aphasia, left spatial neglect, and limb and magnetic apraxia due to right anterior cerebral artery infarction. 61
22506227 2011
15
Spontaneous intra-cranial arterial dissection frequently causes anterior cerebral artery infarction. 61
21402388 2011
16
Bilateral anterior cerebral artery infarction following viper bite. 61
19753762 2009
17
Paradoxical progression of intracranial tuberculomas and anterior cerebral artery infarction. 61
18591510 2008
18
Laryngeal dystonia in a patient with bilateral anterior cerebral artery infarction during treatment of delirium with haloperidol. 61
18442876 2008
19
Anterior cerebral artery infarction: stroke mechanism and clinical-imaging study in 100 patients. 61
18541871 2008
20
Involuntary masturbation and hemiballismus after bilateral anterior cerebral artery infarction. 61
17961914 2008
21
["Hypermetamorphosis". Heinrich Neumann's (1814-1884) legacy]. 61
17119892 2007
22
[Exophiala species--a rare cause of endocarditis with cerebral abscess formation]. 61
15856151 2005
23
The impact of extensive medial frontal lobe damage on 'Theory of Mind' and cognition. 61
14998913 2004
24
Impaired volitional closure of the left eyelid after right anterior cerebral artery infarction: apraxia due to interhemispheric disconnection? 61
14967778 2004
25
Single stroke dementia: insights from 12 cases in Singapore. 61
12417363 2002
26
Unusually prolonged progressing stroke: an expanding anterior cerebral artery infarction. 61
11810013 2002
27
BIPLEDs in akinetic mutism caused by bilateral anterior cerebral artery infarction. 61
11514256 2001
28
Clinical effects of anterior cerebral artery infarction. 61
17895117 1998
29
Motor behavior in stroke patients with isolated medial frontal ischemic infarction. 61
9303021 1997
30
Alien hand syndrome: influence of neglect on the clinical presentation of frontal and callosal variants. 61
9220259 1997
31
[Akinetic mutism with right hemiplegia caused by infarction in the territory of the left anterior cerebral artery]. 61
8761628 1996
32
Post-hemiplegic dystonia following right anterior cerebral artery infarction. 61
1953523 1991
33
Bilateral anterior cerebral artery infarction resulting from explosion-type injury to the head and neck. 61
2057983 1991
34
Left alien hand sign and mirror writing after left anterior cerebral artery infarction. 61
2008645 1991
35
Left-handed mirror writing following right anterior cerebral artery infarction: evidence for nonmirror transformation of motor programs by right supplementary motor area. 61
3336465 1988
36
Radiology of anterior cerebral artery infarction. 61
6478807 1984
37
Left medial parietal lobe and receptive language functions: mixed transcortical aphasia after left anterior cerebral artery infarction. 61
7188794 1980

Variations for Anterior Cerebral Artery Infarction

Expression for Anterior Cerebral Artery Infarction

Search GEO for disease gene expression data for Anterior Cerebral Artery Infarction.

Pathways for Anterior Cerebral Artery Infarction

GO Terms for Anterior Cerebral Artery Infarction

Cellular components related to Anterior Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 SERPINC1 PRL PLG PLAT KITLG IGFBP2
2 collagen-containing extracellular matrix GO:0062023 9.67 SERPINC1 PLG PLAT F2
3 extracellular region GO:0005576 9.61 SERPINC1 PRL PLG PLAT KITLG IGFBP2
4 blood microparticle GO:0072562 9.58 SERPINC1 PLG F2
5 terminal bouton GO:0043195 9.33 TH P2RX4 P2RX3
6 integral component of nuclear inner membrane GO:0005639 9.32 P2RX4 P2RX3
7 neuronal cell body GO:0043025 9.02 TH RBFOX3 P2RX4 P2RX3 EEF1A2

Biological processes related to Anterior Cerebral Artery Infarction according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 response to ATP GO:0033198 9.54 P2RX4 P2RX3
2 cellular response to ATP GO:0071318 9.52 P2RX4 P2RX3
3 inorganic cation transmembrane transport GO:0098662 9.51 P2RX4 P2RX3
4 hemostasis GO:0007599 9.5 SERPINC1 PLG F2
5 positive regulation of calcium-mediated signaling GO:0050850 9.49 P2RX4 P2RX3
6 positive regulation of calcium ion transport into cytosol GO:0010524 9.48 P2RX4 P2RX3
7 regulation of blood coagulation GO:0030193 9.46 SERPINC1 F2
8 behavioral response to pain GO:0048266 9.43 P2RX4 P2RX3
9 negative regulation of fibrinolysis GO:0051918 9.4 PLG F2
10 purinergic nucleotide receptor signaling pathway GO:0035590 9.37 P2RX4 P2RX3
11 cellular protein metabolic process GO:0044267 9.35 SERPINC1 PRL PLG IGFBP2 F2
12 fibrinolysis GO:0042730 9.33 PLG PLAT F2
13 positive regulation of lipid kinase activity GO:0090218 9.26 F2 EEF1A2
14 blood coagulation GO:0007596 9.1 SERPINC1 PLG PLAT P2RX4 P2RX3 F2

Molecular functions related to Anterior Cerebral Artery Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type peptidase activity GO:0008236 9.5 PLG PLAT F2
2 amino acid binding GO:0016597 9.26 TH AGXT
3 extracellularly ATP-gated cation channel activity GO:0004931 9.16 P2RX4 P2RX3
4 signaling receptor binding GO:0005102 9.1 PLG PLAT P2RX4 IGFBP2 F2 AVP
5 purinergic nucleotide receptor activity GO:0001614 8.96 P2RX4 P2RX3

Sources for Anterior Cerebral Artery Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....