Anterior Cranial Fossa Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Anterior Cranial Fossa Meningioma

MalaCards integrated aliases for Anterior Cranial Fossa Meningioma:

Name: Anterior Cranial Fossa Meningioma ¹¹ ¹⁴ ⁷¹

Meningioma of the Anterior Fossa ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4436

NCIt ⁴⁹ C5286

UMLS ⁷¹ C1332301

Sources

Summaries for Anterior Cranial Fossa Meningioma

MalaCards based summary: Anterior Cranial Fossa Meningioma, also known as meningioma of the anterior fossa, is related to meningioma, familial and full schwannomatosis, and has symptoms including headache and seizures. An important gene associated with Anterior Cranial Fossa Meningioma is TRAF7 (TNF Receptor Associated Factor 7), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Hedgehog signaling pathway. Affiliated tissues include brain, and related phenotypes are Increased proliferation and neoplasm

Sources

Related Diseases for Anterior Cranial Fossa Meningioma

Diseases related to Anterior Cranial Fossa Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)

#	Related Disease	Score	Top Affiliating Genes
1	meningioma, familial	28.1	TRAF7 SUFU SMARCE1 SMARCB1 PTCH1 POLR2A
2	full schwannomatosis	10.2	SMARCB1 NF2
3	posterior pituitary gland neoplasm	10.2	SMARCB1 NF2
4	intraneural perineurioma	10.2	TRAF7 NF2
5	peripheral nerve schwannoma	10.2	SMARCB1 NF2
6	pineal region meningioma	10.2	SMARCB1 NF2
7	petroclival meningioma	10.2	TRAF7 NF2
8	plexiform schwannoma	10.2	SMARCB1 NF2
9	schwannomatosis 1	10.2	SMARCB1 NF2
10	cerebellopontine angle tumor	10.2	SMARCB1 NF2
11	cellular schwannoma	10.2	SMARCB1 NF2
12	cerebellopontine angle meningioma	10.2	SMARCE1 NF2
13	atypical neurofibroma	10.2	SMARCB1 NF2
14	optic nerve neoplasm	10.2	SMARCB1 NF2
15	melanotic neurilemmoma	10.2	SMARCB1 NF2
16	schwannoma of twelfth cranial nerve	10.2	SMARCB1 NF2
17	hypoglossal nerve disease	10.2	SMARCB1 NF2
18	spinal cord ependymoma	10.2	SMARCB1 NF2
19	cranial nerve malignant neoplasm	10.2	SMARCB1 NF2
20	anaplastic ependymoma	10.2	SMARCB1 NF2
21	plexiform neurofibroma	10.1	SMARCB1 NF2
22	high grade ependymoma	10.1	SMARCB1 NF2
23	cerebral ventricle cancer	10.1	SMARCB1 NF2
24	optic nerve sheath meningioma	10.1	TRAF7 SMARCB1 NF2
25	breast cancer	10.1
26	dementia, lewy body	10.1
27	parkinsonism	10.1
28	psychotic disorder	10.1
29	chordoid meningioma	10.1	TRAF7 SMARCB1 NF2
30	melanotic medulloblastoma	10.1	SUFU SMARCB1
31	foramen magnum meningioma	10.1	TRAF7 POLR2A NF2
32	psammomatous meningioma	10.1	TRAF7 POLR2A NF2
33	sphenoorbital meningioma	10.1	TRAF7 SMARCE1 NF2
34	microcystic meningioma	10.1	TRAF7 SMARCE1 NF2
35	cerebrospinal fluid leak	10.1
36	solitary fibrous tumor/hemangiopericytoma	10.1	TRAF7 SMARCE1 SMARCB1
37	clark-baraitser syndrome	10.1	SMARCE1 SMARCB1
38	cerebrum cancer	10.1	SMARCB1 NF2
39	supratentorial cancer	10.1	SMARCB1 NF2
40	foster-kennedy syndrome	10.0	MAL2 HOXA6
41	petrous apex meningioma	10.0	NF2 EPB41
42	autosomal dominant intellectual developmental disorder	10.0	SMARCE1 SMARCB1
43	small intestine leiomyoma	10.0	PTCH1 NF2
44	tuberculum sellae meningioma	10.0	TRAF7 NF2 EPB41
45	childhood meningioma	10.0	TRAF7 SMARCE1 SMARCB1 NF2
46	sella turcica neoplasm	10.0	TRAF7 NF2 EPB41
47	spinal cancer	10.0	TRAF7 SMARCE1 SMARCB1 NF2
48	cavernous sinus meningioma	9.9	TRAF7 SMARCE1 POLR2A NF2
49	intraventricular meningioma	9.9	TRAF7 SMARCE1 POLR2A NF2
50	tinea capitis	9.9	PTCH1 NF2

Graphical network of the top 20 diseases related to Anterior Cranial Fossa Meningioma:

Sources

Symptoms & Phenotypes for Anterior Cranial Fossa Meningioma

UMLS symptoms related to Anterior Cranial Fossa Meningioma:

headache; seizures

GenomeRNAi Phenotypes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

MGI Mouse Phenotypes related to Anterior Cranial Fossa Meningioma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.43	KLF4 NF2 POLR2A PTCH1 SMARCB1 SUFU
2	digestive/alimentary	MP:0005381	9.1	KLF4 NF2 POLR2A PTCH1 SMARCB1 SUFU

Sources

Drugs & Therapeutics for Anterior Cranial Fossa Meningioma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Analysis of Post Surgical Response in A Fifty-Six Year Old Female With An Incidental Large Left Anterior Cranial Fossa Meningioma	Completed	NCT00945230

Search NIH Clinical Center for Anterior Cranial Fossa Meningioma

Sources

Genetic Tests for Anterior Cranial Fossa Meningioma

Sources

Anatomical Context for Anterior Cranial Fossa Meningioma

Organs/tissues related to Anterior Cranial Fossa Meningioma:

MalaCards : Brain

Sources

Publications for Anterior Cranial Fossa Meningioma

Articles related to Anterior Cranial Fossa Meningioma:

#	Title	Authors	PMID	Year
1	Minimally invasive nummular approach to a giant meningioma of the anterior fossa. ⁶²	Mandel M...da Silva IAF	35673653	2022
2	Multifocal spinal glioblastoma and leptomeningeal carcinomatosis in an elderly male with hydrocephalus and myelopathy. ⁶²	Koutsouras GW...Babu H	34992912	2021
3	Anatomical Variations in the Location of Veins Draining Into the Anterior Superior Sagittal Sinus: Implications for the Transbasal Approach. ⁶²	Borghei-Razavi H...Recinos PF	31748805	2020
4	Secondary Parkinsonism Due to a Large Anterior Cranial Fossa Meningioma. ⁶²	Al-Janabi WSA...Memon AB	31139580	2019
5	The Radiographic Effects of Surgical Approach and Use of Retractors on the Brain After Anterior Cranial Fossa Meningioma Resection. ⁶²	Chaichana KL...Quinones-Hinojosa A	29367000	2018
6	Incidental finding of anterior cranial fossa meningioma on 18F-fluoride PET/CT. ⁶²	Zacchi SR...Buchpiguel CA	24096998	2013
7	Nasoethmoid schwannoma with intracranial extension. Case report and review of literature. ⁶²	George KJ...Price R	19234915	2009
8	Psychiatric symptoms and an anterior cranial fossa meningioma. ⁶²	Hutchinson G...Neehall JE	9861864	1998

Sources

Genes for Anterior Cranial Fossa Meningioma

Genes related to Anterior Cranial Fossa Meningioma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	6.5	DISEASES inferred ¹⁴
2	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	6.25	DISEASES inferred ¹⁴
3	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.26	DISEASES inferred ¹⁴
4	POLR2A	RNA Polymerase II Subunit A	Protein Coding	5.23	DISEASES inferred ¹⁴
5	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	5.15	DISEASES inferred ¹⁴
6	ITPK1	Inositol-Tetrakisphosphate 1-Kinase	Protein Coding	5.14	DISEASES inferred ¹⁴
7	KLF4	KLF Transcription Factor 4	Protein Coding	5.08	DISEASES inferred ¹⁴
8	HOXA6	Homeobox A6	Protein Coding	4.64	DISEASES inferred ¹⁴
9	MAL2	Mal, T Cell Differentiation Protein 2	Protein Coding	4.57	DISEASES inferred ¹⁴
10	EPB41	Erythrocyte Membrane Protein Band 4.1	Protein Coding	4.54	DISEASES inferred ¹⁴
11	PTCH1	Patched 1	Protein Coding	4.46	DISEASES inferred ¹⁴
12	SUFU	SUFU Negative Regulator Of Hedgehog Signaling	Protein Coding	4.45	DISEASES inferred ¹⁴

Sources

Variations for Anterior Cranial Fossa Meningioma

Sources

Expression for Anterior Cranial Fossa Meningioma

Search GEO for disease gene expression data for Anterior Cranial Fossa Meningioma.

Sources

Pathways for Anterior Cranial Fossa Meningioma

Pathways related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Wnt / Hedgehog / Notch ³	11.59	SUFU PTCH1 KLF4
2	Hedgehog signaling pathway ⁷⁴	10.99	SUFU PTCH1
3	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ⁶⁶	10.9	SMARCE1 SMARCB1
4	Hedgehog signaling events mediated by Gli proteins ⁶¹	10.84	SUFU PTCH1
5	Tumor suppressor activity of SMARCB1 ⁷⁴ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶	10.33	SMARCE1 SMARCB1 PTCH1
6	Validated nuclear estrogen receptor beta network ⁶¹	10.13	SMARCE1 SMARCB1

Sources

GO Terms for Anterior Cranial Fossa Meningioma

Cellular components related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nBAF complex	GO:0071565	9.62	SMARCE1 SMARCB1
2	RSC-type complex	GO:0016586	9.56	SMARCE1 SMARCB1
3	npBAF complex	GO:0071564	9.46	SMARCE1 SMARCB1
4	brahma complex	GO:0035060	9.26	SMARCE1 SMARCB1
5	bBAF complex	GO:0140092	8.92	SMARCE1 SMARCB1

Biological processes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleosome disassembly	GO:0006337	9.46	SMARCE1 SMARCB1
2	negative regulation of DNA-binding transcription factor activity	GO:0043433	9.35	SUFU PTCH1 KLF4
3	positive regulation of cell differentiation	GO:0045597	9.1	SMARCE1 SMARCB1 NF2

Sources

Sources for Anterior Cranial Fossa Meningioma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ANT022 MIFTS: 26	Anterior Cranial Fossa Meningioma Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables