Anterior Cranial Fossa Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Anterior Cranial Fossa Meningioma

MalaCards integrated aliases for Anterior Cranial Fossa Meningioma:

Name: Anterior Cranial Fossa Meningioma ¹² ¹⁵ ⁷⁴

Meningioma of the Anterior Fossa ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4436

NCIt ⁵¹ C5286

UMLS ⁷⁴ C1332301

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Summaries for Anterior Cranial Fossa Meningioma

MalaCards based summary : Anterior Cranial Fossa Meningioma, also known as meningioma of the anterior fossa, is related to spinal meningioma and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Anterior Cranial Fossa Meningioma is PGRMC1 (Progesterone Receptor Membrane Component 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. Affiliated tissues include colon, breast and brain.

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Related Diseases for Anterior Cranial Fossa Meningioma

Diseases related to Anterior Cranial Fossa Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)

#	Related Disease	Score	Top Affiliating Genes
1	spinal meningioma	30.5	CHGA NF2 PGR
2	meningioma, familial	29.8	KANTR NF2 PGR SYP
3	optic nerve neoplasm	10.4	NF2 SYP
4	malignant skin fibrous histiocytoma	10.4	CHGA F7
5	malignant dermis tumor	10.4	CHGA F7
6	chronic maxillary sinusitis	10.4	RHNO1 SYP
7	malignant pheochromocytoma	10.4	CHGA SYP
8	central neurocytoma	10.4	CHGA SYP
9	cranial nerve malignant neoplasm	10.4	CHGA SYP
10	olfactory neuroblastoma	10.4	CHGA SYP
11	cerebellar liponeurocytoma	10.4	CHGA SYP
12	hemophilia a	10.4	F3 F7
13	gastric tubular adenocarcinoma	10.4	CHGA SYP
14	cervix small cell carcinoma	10.4	CHGA SYP
15	binswanger's disease	10.4	CHGA SYP
16	carcinoid syndrome	10.4	CHGA SYP
17	granulosa cell tumor of the ovary	10.4	CHGA SYP
18	horseshoe kidney	10.4	CHGA SYP
19	tracheal stenosis	10.4	PGRMC1 RHNO1
20	ureter small cell carcinoma	10.3	CHGA SYP
21	tracheal disease	10.3	PGRMC1 RHNO1
22	esophageal neuroendocrine tumor	10.3	CHGA SYP
23	urinary bladder small cell neuroendocrine carcinoma	10.3	CHGA SYP
24	ovarian large-cell neuroendocrine carcinoma	10.3	CHGA SYP
25	auditory system cancer	10.3	CHGA SYP
26	acinar cell cystadenocarcinoma	10.3	CHGA SYP
27	peritoneal serous adenocarcinoma	10.3	CHGA SYP
28	cellular ependymoma	10.3	CHGA SYP
29	benign ependymoma	10.3	NF2 SYP
30	primary hepatic neuroendocrine carcinoma	10.3	CHGA SYP
31	small cell carcinoma of the bladder	10.3	CHGA SYP
32	gastrointestinal neuroendocrine tumor	10.3	CHGA SYP
33	pulmonary large cell neuroendocrine carcinoma	10.3	CHGA SYP
34	large cell neuroendocrine carcinoma	10.3	CHGA SYP
35	gallbladder small cell carcinoma	10.3	CHGA SYP
36	chordoid meningioma	10.3	CHGA SYP
37	cauda equina neoplasm	10.3	CHGA SYP
38	conjunctival disease	10.3	PLG RHNO1
39	conventional angiosarcoma	10.3	CHGA SYP
40	olfactory nerve neoplasm	10.3	CHGA SYP
41	autonomic nervous system benign neoplasm	10.3	CHGA SYP
42	partial motor epilepsy	10.3	F3 SYP
43	nodular ganglioneuroblastoma	10.3	CHGA SYP
44	pulmonary sclerosing hemangioma	10.3	CHGA SYP
45	pancreatic cystadenoma	10.3	CEACAM5 CHGA
46	pineocytoma	10.3	CHGA SYP
47	anaplastic ependymoma	10.3	NF2 SYP
48	pancreatoblastoma	10.3	CHGA SYP
49	ovarian mucinous neoplasm	10.3	CEACAM5 SYP
50	subependymoma	10.3	CHGA SYP

Graphical network of the top 20 diseases related to Anterior Cranial Fossa Meningioma:

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Symptoms & Phenotypes for Anterior Cranial Fossa Meningioma

UMLS symptoms related to Anterior Cranial Fossa Meningioma:

seizures, headache

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Drugs & Therapeutics for Anterior Cranial Fossa Meningioma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Actigraphic Measurement of a Neurosurgical Procedure	Completed	NCT00945230	Not Applicable

Search NIH Clinical Center for Anterior Cranial Fossa Meningioma

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Genetic Tests for Anterior Cranial Fossa Meningioma

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Anatomical Context for Anterior Cranial Fossa Meningioma

MalaCards organs/tissues related to Anterior Cranial Fossa Meningioma:

⁴²

Colon, Breast, Brain, Lung, Kidney, Liver, Spinal Cord

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Publications for Anterior Cranial Fossa Meningioma

Articles related to Anterior Cranial Fossa Meningioma:

#	Title	Authors	Year
1	The Radiographic Effects of Surgical Approach and Use of Retractors on the Brain After Anterior Cranial Fossa Meningioma Resection. ( 29367000 )	Chaichana KL...Quinones-Hinojosa A	2018
2	Incidental finding of anterior cranial fossa meningioma on 18F-fluoride PET/CT. ( 24096998 )	Zacchi SR...Buchpiguel CA	2013
3	Psychiatric symptoms and an anterior cranial fossa meningioma. ( 9861864 )	Hutchinson G...Neehall JE	1998

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Genes for Anterior Cranial Fossa Meningioma

Genes related to Anterior Cranial Fossa Meningioma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	14.8	DISEASES inferred ¹⁵
2	NF2	Neurofibromin 2	Protein Coding	14.58	DISEASES inferred ¹⁵
3	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	14.5	DISEASES inferred ¹⁵
4	F7	Coagulation Factor VII	Protein Coding	14.15	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	13.87	DISEASES inferred ¹⁵
6	SYP	Synaptophysin	Protein Coding	13.71	DISEASES inferred ¹⁵
7	F3	Coagulation Factor III, Tissue Factor	Protein Coding	13.41	DISEASES inferred ¹⁵
8	PGR	Progesterone Receptor	Protein Coding	13.23	DISEASES inferred ¹⁵
9	PLG	Plasminogen	Protein Coding	13.2	DISEASES inferred ¹⁵
10	F2	Coagulation Factor II, Thrombin	Protein Coding	13.12	DISEASES inferred ¹⁵
11	KANTR	KDM5C Adjacent Transcript	RNA Gene	3.71	DISEASES inferred ¹⁵
12	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	3.13	DISEASES inferred ¹⁵

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Variations for Anterior Cranial Fossa Meningioma

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Expression for Anterior Cranial Fossa Meningioma

Search GEO for disease gene expression data for Anterior Cranial Fossa Meningioma.

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Pathways for Anterior Cranial Fossa Meningioma

Pathways related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁷ Show member pathways Disinhibition of SNARE formation ⁶⁷ Hemostasis ⁶⁷ Platelet activation, signaling and aggregation ⁶⁷ Platelet degranulation ⁶⁷	12.93	CEACAM5 F2 F3 F7 PLG
2	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.94	F2 F7 PLG
3	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	11.6	CHGA F2 PLG
4	Adhesion ⁴	11.52	CEACAM5 F3 PLG
5	Formation of Fibrin Clot (Clotting Cascade) ⁶⁷ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁶ Common Pathway of Fibrin Clot Formation ⁶⁷ Extrinsic Pathway of Fibrin Clot Formation ⁶⁷ Extrinsic Prothrombin Activation Pathway ⁶⁵ Intrinsic Pathway of Fibrin Clot Formation ⁶⁷	11.46	F2 F3 F7 PLG
6	Complement and coagulation cascades ¹ ³⁸	11.07	F2 F3 F7 PLG
7	Syndecan-4-mediated signaling events ¹	10.9	F2 PLG
8	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁷	10.69	F2 PLG
9	Warfarin Pathway, Pharmacodynamics ⁶²	10.33	F2 F7

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GO Terms for Anterior Cranial Fossa Meningioma

Cellular components related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type peptidase complex	GO:1905286	8.62	F3 F7

Biological processes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	fibrinolysis	GO:0042730	9.46	F2 PLG
2	positive regulation of blood coagulation	GO:0030194	9.43	F2 F7
3	positive regulation of positive chemotaxis	GO:0050927	9.4	F3 F7
4	negative regulation of fibrinolysis	GO:0051918	9.37	F2 PLG
5	blood coagulation, extrinsic pathway	GO:0007598	9.32	F3 F7
6	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	GO:1900738	9.26	CHGA F2
7	blood coagulation	GO:0007596	9.26	F2 F3 F7 PLG
8	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:0010641	9.16	F3 F7
9	hemostasis	GO:0007599	8.92	F2 F3 F7 PLG

Molecular functions related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:0005496	9.16	PGR PGRMC1
2	serine-type peptidase activity	GO:0008236	9.13	F2 F7 PLG
3	serine-type endopeptidase activity	GO:0004252	8.92	F2 F3 F7 PLG

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Sources for Anterior Cranial Fossa Meningioma

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