Anterior Cranial Fossa Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Anterior Cranial Fossa Meningioma

MalaCards integrated aliases for Anterior Cranial Fossa Meningioma:

Name: Anterior Cranial Fossa Meningioma ¹² ¹⁵ ⁷³

Meningioma of the Anterior Fossa ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4436

NCIt ⁵⁰ C5286

UMLS ⁷³ C1332301

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Summaries for Anterior Cranial Fossa Meningioma

MalaCards based summary : Anterior Cranial Fossa Meningioma, also known as meningioma of the anterior fossa, is related to tracheal disease and cecal disease, and has symptoms including seizures and headache. An important gene associated with Anterior Cranial Fossa Meningioma is PGRMC1 (Progesterone Receptor Membrane Component 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Microglia Activation During Neuroinflammation: Overview. Affiliated tissues include brain, lung and colon, and related phenotypes are Increased proliferation and cardiovascular system

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Related Diseases for Anterior Cranial Fossa Meningioma

Diseases related to Anterior Cranial Fossa Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)

#	Related Disease	Score	Top Affiliating Genes
1	tracheal disease	10.3	PGRMC1 RHNO1
2	cecal disease	10.3	CHGA PGRMC1
3	malignant skin fibrous histiocytoma	10.3	CHGA F7
4	chronic maxillary sinusitis	10.3	RHNO1 SYP
5	anaplastic ependymoma	10.3	NF2 SYP
6	carcinoid tumors, intestinal	10.2	CHGA SYP
7	respiratory system benign neoplasm	10.2	CHGA SYP
8	central neurocytoma	10.2	CHGA SYP
9	cranial nerve malignant neoplasm	10.2	CHGA SYP
10	papillary ependymoma	10.2	CHGA SYP
11	gastric squamous cell carcinoma	10.2	CHGA SYP
12	gastric small cell carcinoma	10.2	CHGA SYP
13	pancreatoblastoma	10.2	CHGA SYP
14	non-functioning pancreatic endocrine tumor	10.2	CHGA SYP
15	binswanger's disease	10.2	CHGA SYP
16	carcinoid syndrome	10.2	CHGA SYP
17	horseshoe kidney	10.2	CHGA SYP
18	subependymoma	10.2	CHGA SYP
19	benign meningioma	10.2	NF2 PGR
20	ureter small cell carcinoma	10.2	CHGA SYP
21	esophageal neuroendocrine tumor	10.2	CHGA SYP
22	urinary bladder small cell neuroendocrine carcinoma	10.2	CHGA SYP
23	ovarian large-cell neuroendocrine carcinoma	10.2	CHGA SYP
24	dermoid cyst	10.2	CHGA PGR
25	facial nerve disease	10.2	KANTR NF2
26	auditory system cancer	10.2	CHGA SYP
27	adenoma of the pancreas	10.2	CHGA SYP
28	acinar cell cystadenocarcinoma	10.2	CHGA SYP
29	peritoneal serous adenocarcinoma	10.2	CHGA SYP
30	gallbladder small cell carcinoma	10.2	CHGA SYP
31	primary hepatic neuroendocrine carcinoma	10.2	CHGA SYP
32	small cell carcinoma of the bladder	10.2	CHGA SYP
33	spermatocele	10.2	PGR SYP
34	perivascular epithelioid cell tumor	10.2	PGR SYP
35	gastrointestinal neuroendocrine tumor	10.2	CHGA SYP
36	sertoli cell tumor	10.2	PGR SYP
37	pulmonary large cell neuroendocrine carcinoma	10.2	CHGA SYP
38	chordoid meningioma	10.2	CHGA SYP
39	petrous apex meningioma	10.2	KANTR PGRMC1
40	radiation cystitis	10.2	F7 KANTR
41	cauda equina neoplasm	10.2	CHGA SYP
42	conventional angiosarcoma	10.2	CHGA SYP
43	foramen magnum meningioma	10.2	KANTR NF2
44	partial motor epilepsy	10.2	F3 SYP
45	abducens nerve disease	10.2	KANTR SYP
46	functional colonic disease	10.2	KANTR SYP
47	intraocular retinoblastoma	10.2	KANTR SYP
48	small cell sarcoma	10.2	NF2 TP53
49	olfactory nerve neoplasm	10.2	CHGA SYP
50	benign ependymoma	10.2	NF2 SYP

Graphical network of the top 20 diseases related to Anterior Cranial Fossa Meningioma:

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Symptoms & Phenotypes for Anterior Cranial Fossa Meningioma

UMLS symptoms related to Anterior Cranial Fossa Meningioma:

seizures, headache

GenomeRNAi Phenotypes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 TP53

MGI Mouse Phenotypes related to Anterior Cranial Fossa Meningioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.91	CHGA F2 F3 F7 PGR PLG
2	mortality/aging	MP:0010768	9.91	CHGA F2 F3 F7 NF2 PGR
3	integument	MP:0010771	9.8	F2 F3 NF2 PGR PLG TP53
4	nervous system	MP:0003631	9.56	CHGA F2 F3 NF2 PGRMC1 PLG
5	neoplasm	MP:0002006	9.55	F3 NF2 PGR PLG TP53
6	reproductive system	MP:0005389	9.17	CHGA F2 NF2 PGR PGRMC1 PLG

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Drugs & Therapeutics for Anterior Cranial Fossa Meningioma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Actigraphic Measurement of a Neurosurgical Procedure	Completed	NCT00945230	Not Applicable

Search NIH Clinical Center for Anterior Cranial Fossa Meningioma

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Genetic Tests for Anterior Cranial Fossa Meningioma

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Anatomical Context for Anterior Cranial Fossa Meningioma

MalaCards organs/tissues related to Anterior Cranial Fossa Meningioma:

⁴¹

Brain, Lung, Colon, Breast, Ovary, Spinal Cord, Cerebellum

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Publications for Anterior Cranial Fossa Meningioma

Articles related to Anterior Cranial Fossa Meningioma:

#	Title	Authors	Year
1	The Radiographic Effects of Surgical Approach and Use of Retractors on the Brain After Anterior Cranial Fossa Meningioma Resection. ( 29367000 )	Chaichana K.L....Quinones-Hinojosa A.	2018
2	Incidental finding of anterior cranial fossa meningioma on 18F-fluoride PET/CT. ( 24096998 )		2013
3	Psychiatric symptoms and an anterior cranial fossa meningioma. ( 9861864 )	Hutchinson G....Neehall J.E.	1998

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Genes for Anterior Cranial Fossa Meningioma

Genes related to Anterior Cranial Fossa Meningioma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	14.74	DISEASES inferred ¹⁵
2	NF2	Neurofibromin 2	Protein Coding	14.52	DISEASES inferred ¹⁵
3	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	14.45	DISEASES inferred ¹⁵
4	F7	Coagulation Factor VII	Protein Coding	14.08	DISEASES inferred ¹⁵
5	CHGA	Chromogranin A	Protein Coding	13.83	DISEASES inferred ¹⁵
6	SYP	Synaptophysin	Protein Coding	13.66	DISEASES inferred ¹⁵
7	F3	Coagulation Factor III, Tissue Factor	Protein Coding	13.34	DISEASES inferred ¹⁵
8	PGR	Progesterone Receptor	Protein Coding	13.18	DISEASES inferred ¹⁵
9	PLG	Plasminogen	Protein Coding	13.13	DISEASES inferred ¹⁵
10	TP53	Tumor Protein P53	Protein Coding	13.06	DISEASES inferred ¹⁵
11	F2	Coagulation Factor II, Thrombin	Protein Coding	13.04	DISEASES inferred ¹⁵
12	KANTR	KDM5C Adjacent Transcript	RNA Gene	3.65	DISEASES inferred ¹⁵

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Variations for Anterior Cranial Fossa Meningioma

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Expression for Anterior Cranial Fossa Meningioma

Search GEO for disease gene expression data for Anterior Cranial Fossa Meningioma.

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Pathways for Anterior Cranial Fossa Meningioma

Pathways related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.79	F2 F7 PLG TP53
2	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	11.6	CHGA F2 PLG
3	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.46	F2 F3 F7 PLG
4	Complement and coagulation cascades ¹ ³⁷	11.07	F2 F3 F7 PLG
5	Syndecan-4-mediated signaling events ¹	10.9	F2 PLG
6	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶	10.69	F2 PLG
7	Warfarin Pathway, Pharmacodynamics ⁶¹	10.43	F2 F7

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GO Terms for Anterior Cranial Fossa Meningioma

Cellular components related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type peptidase complex	GO:1905286	8.62	F3 F7

Biological processes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.48	F2 TP53
2	fibrinolysis	GO:0042730	9.46	F2 PLG
3	positive regulation of blood coagulation	GO:0030194	9.43	F2 F7
4	positive regulation of positive chemotaxis	GO:0050927	9.4	F3 F7
5	negative regulation of fibrinolysis	GO:0051918	9.37	F2 PLG
6	blood coagulation, extrinsic pathway	GO:0007598	9.32	F3 F7
7	positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	GO:1900738	9.26	CHGA F2
8	blood coagulation	GO:0007596	9.26	F2 F3 F7 PLG
9	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:0010641	9.16	F3 F7
10	hemostasis	GO:0007599	8.92	F2 F3 F7 PLG

Molecular functions related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:0005496	9.16	PGR PGRMC1
2	serine-type peptidase activity	GO:0008236	9.13	F2 F7 PLG
3	serine-type endopeptidase activity	GO:0004252	8.92	F2 F3 F7 PLG

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Sources for Anterior Cranial Fossa Meningioma

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²⁰ GeneAnalytics

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⁴¹ MalaCards

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

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⁷⁶ Wikipedia