Anterior Cranial Fossa Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Anterior Cranial Fossa Meningioma

MalaCards integrated aliases for Anterior Cranial Fossa Meningioma:

Name: Anterior Cranial Fossa Meningioma ¹² ¹⁵ ⁷³

Meningioma of the Anterior Fossa ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4436

NCIt ⁵⁰ C5286

UMLS ⁷³ C1332301

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Summaries for Anterior Cranial Fossa Meningioma

MalaCards based summary : Anterior Cranial Fossa Meningioma, also known as meningioma of the anterior fossa, is related to tracheal stenosis and tracheal disease, and has symptoms including headache and seizures. An important gene associated with Anterior Cranial Fossa Meningioma is PGRMC1 (Progesterone Receptor Membrane Component 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. Affiliated tissues include brain, and related phenotypes are Increased proliferation and cardiovascular system

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Related Diseases for Anterior Cranial Fossa Meningioma

Diseases related to Anterior Cranial Fossa Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)

#	Related Disease	Score	Top Affiliating Genes
1	tracheal stenosis	10.8	PGRMC1 RHNO1
2	tracheal disease	10.8	PGRMC1 RHNO1
3	cecal disease	10.7	CHGA PGRMC1
4	tanycytic ependymoma	10.7	CHGA NF2
5	lung meningioma	10.7	NF2 PGR
6	petrous apex meningioma	10.6	KANTR PGRMC1
7	foramen magnum meningioma	10.6	KANTR NF2
8	benign meningioma	10.6	NF2 PGR
9	clear cell meningioma	10.6	CHGA PGR
10	malignant skin fibrous histiocytoma	10.6	CHGA F7
11	pancreatic serous cystadenoma	10.6	CHGA PGR
12	substernal goiter	10.5	F7 KANTR
13	malignant dermis tumor	10.5	CHGA F7
14	facial nerve disease	10.5	KANTR NF2
15	dermoid cyst	10.5	CHGA PGR
16	visual agnosia	10.5	F7 KANTR
17	chronic myocardial ischemia	10.5	CHGA PLG
18	cerebral convexity meningioma	10.5	NF2 TP53
19	conjugate gaze palsy	10.5	F3 PLG
20	peritoneal mesothelioma	10.5	NF2 PGR
21	spinal cancer	10.5	NF2 TP53
22	chordoid glioma	10.4	NF2 TP53
23	cerebellopontine angle tumor	10.4	KANTR NF2
24	malignant ependymoma	10.4	NF2 TP53
25	radiation cystitis	10.4	F7 KANTR
26	cellular ependymoma	10.4	CHGA TP53
27	corneal abscess	10.4	PGR PLG
28	hemophilia a	10.4	F3 F7
29	atypical follicular adenoma	10.4	CHGA TP53
30	small cell sarcoma	10.4	NF2 TP53
31	hemometra	10.4	F3 KANTR
32	conjunctival disease	10.4	PLG RHNO1
33	vertebral artery occlusion	10.4	F3 PLG
34	lemierre's syndrome	10.4	F3 PLG
35	acute anterolateral myocardial infarction	10.3	KANTR PLG
36	posterolateral myocardial infarction	10.3	KANTR PLG
37	facial neuralgia	10.3	KANTR PLG
38	cerebral arteritis	10.3	KANTR PLG
39	shwartzman phenomenon	10.3	F3 KANTR
40	pulmonary blastoma	10.3	CHGA TP53
41	apical myocardial infarction	10.3	KANTR PLG
42	tubular adenocarcinoma	10.3	CHGA PGR
43	optic nerve neoplasm	10.3	NF2 TP53
44	endometrium carcinoma in situ	10.3	PGR TP53
45	breast papillary carcinoma	10.3	CHGA PGR
46	vestibular gland benign neoplasm	10.3	PGR TP53
47	pleomorphic xanthoastrocytoma	10.3	CHGA TP53
48	alveolar periostitis	10.3	KANTR PLG
49	bartholin's gland adenoma	10.3	PGR TP53
50	intermediate coronary syndrome	10.3	F3 PLG

Graphical network of the top 20 diseases related to Anterior Cranial Fossa Meningioma:

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Symptoms & Phenotypes for Anterior Cranial Fossa Meningioma

UMLS symptoms related to Anterior Cranial Fossa Meningioma:

headache, seizures

GenomeRNAi Phenotypes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 TP53

MGI Mouse Phenotypes related to Anterior Cranial Fossa Meningioma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.87	CHGA F2 F3 F7 PGR PLG
2	mortality/aging	MP:0010768	9.81	F7 NF2 PGR PGRMC1 PLG TP53
3	integument	MP:0010771	9.73	F2 F3 NF2 PGR PLG TP53
4	neoplasm	MP:0002006	9.35	F3 NF2 PGR PLG TP53
5	reproductive system	MP:0005389	9.17	CHGA F2 NF2 PGR PGRMC1 PLG

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Drugs & Therapeutics for Anterior Cranial Fossa Meningioma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Actigraphic Measurement of a Neurosurgical Procedure	Completed	NCT00945230	Not Applicable

Search NIH Clinical Center for Anterior Cranial Fossa Meningioma

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Genetic Tests for Anterior Cranial Fossa Meningioma

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Anatomical Context for Anterior Cranial Fossa Meningioma

MalaCards organs/tissues related to Anterior Cranial Fossa Meningioma:

⁴¹

Brain

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Publications for Anterior Cranial Fossa Meningioma

Articles related to Anterior Cranial Fossa Meningioma:

#	Title	Authors	Year
1	The Radiographic Effects of Surgical Approach and Use of Retractors on the Brain After Anterior Cranial Fossa Meningioma Resection. ( 29367000 )	Chaichana K.L....Quinones-Hinojosa A.	2018
2	Incidental finding of anterior cranial fossa meningioma on 18F-fluoride PET/CT. ( 24096998 )	Zacchi S.R....Buchpiguel C.A.	2013
3	Psychiatric symptoms and an anterior cranial fossa meningioma. ( 9861864 )	Hutchinson G....Neehall J.E.	1998

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Genes for Anterior Cranial Fossa Meningioma

Genes related to Anterior Cranial Fossa Meningioma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGRMC1	Progesterone Receptor Membrane Component 1	Protein Coding	14.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	NF2	Neurofibromin 2	Protein Coding	14.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	14.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	F7	Coagulation Factor VII	Protein Coding	14.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CHGA	Chromogranin A	Protein Coding	14.01	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	F3	Coagulation Factor III, Tissue Factor	Protein Coding	13.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	PGR	Progesterone Receptor	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	PLG	Plasminogen	Protein Coding	13.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	TP53	Tumor Protein P53	Protein Coding	13.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	F2	Coagulation Factor II, Thrombin	Protein Coding	13.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	KANTR	KDM5C Adjacent Transcript	RNA Gene	3.71	DISEASES inferred ¹⁵

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Variations for Anterior Cranial Fossa Meningioma

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Expression for Anterior Cranial Fossa Meningioma

Search GEO for disease gene expression data for Anterior Cranial Fossa Meningioma.

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Pathways for Anterior Cranial Fossa Meningioma

Pathways related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.88	F2 F3 F7 PLG TP53
2	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	11.79	F2 F7 PLG TP53
3	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.46	F2 F3 F7 PLG
4	Complement and coagulation cascades ¹ ³⁷	11.07	F2 F3 F7 PLG
5	Syndecan-4-mediated signaling events ¹	10.86	F2 PLG
6	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶	10.64	F2 PLG
7	Warfarin Pathway, Pharmacodynamics ⁶¹	10.43	F2 F7

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GO Terms for Anterior Cranial Fossa Meningioma

Cellular components related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type peptidase complex	GO:1905286	8.62	F3 F7

Biological processes related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to ionizing radiation	GO:0071479	9.52	RHNO1 TP53
2	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.51	F2 TP53
3	signal peptide processing	GO:0006465	9.49	F2 F7
4	fibrinolysis	GO:0042730	9.48	F2 PLG
5	positive regulation of blood coagulation	GO:0030194	9.46	F2 F7
6	positive regulation of positive chemotaxis	GO:0050927	9.43	F3 F7
7	peptidyl-glutamic acid carboxylation	GO:0017187	9.4	F2 F7
8	negative regulation of fibrinolysis	GO:0051918	9.37	F2 PLG
9	blood coagulation, extrinsic pathway	GO:0007598	9.32	F3 F7
10	positive regulation of platelet-derived growth factor receptor signaling pathway	GO:0010641	9.26	F3 F7
11	blood coagulation	GO:0007596	9.26	F2 F3 F7 PLG
12	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway	GO:1900738	9.16	CHGA F2
13	hemostasis	GO:0007599	8.92	F2 F3 F7 PLG

Molecular functions related to Anterior Cranial Fossa Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	steroid binding	GO:0005496	9.16	PGR PGRMC1
2	serine-type peptidase activity	GO:0008236	9.13	F2 F7 PLG
3	serine-type endopeptidase activity	GO:0004252	8.92	F2 F3 F7 PLG

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