MCID: ANT051
MIFTS: 21

Anterior Cruciate Ligament Tears

Categories: Muscle diseases

Aliases & Classifications for Anterior Cruciate Ligament Tears

MalaCards integrated aliases for Anterior Cruciate Ligament Tears:

Name: Anterior Cruciate Ligament Tears 55

Classifications:



Summaries for Anterior Cruciate Ligament Tears

MalaCards based summary : Anterior Cruciate Ligament Tears is related to osteoarthritis and aging. An important gene associated with Anterior Cruciate Ligament Tears is RLN2 (Relaxin 2). The drugs Parecoxib and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and bone marrow.

Related Diseases for Anterior Cruciate Ligament Tears

Diseases related to Anterior Cruciate Ligament Tears via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 osteoarthritis 10.2
2 aging 10.1
3 body mass index quantitative trait locus 1 10.1
4 hemarthrosis 10.1
5 trochlear dysplasia 10.1

Graphical network of the top 20 diseases related to Anterior Cruciate Ligament Tears:



Diseases related to Anterior Cruciate Ligament Tears

Symptoms & Phenotypes for Anterior Cruciate Ligament Tears

Drugs & Therapeutics for Anterior Cruciate Ligament Tears

Drugs for Anterior Cruciate Ligament Tears (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4 198470-84-7
2
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
3
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
5
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
6
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Racepinephrine Approved Phase 4 329-65-7 838
9 Dexamethasone acetate Phase 4,Not Applicable 1177-87-3
10 Analgesics Phase 4,Not Applicable
11 glucocorticoids Phase 4,Phase 2,Not Applicable
12
protease inhibitors Phase 4,Not Applicable
13 Central Nervous System Depressants Phase 4,Not Applicable
14 Gastrointestinal Agents Phase 4,Not Applicable
15 Cyclooxygenase 2 Inhibitors Phase 4
16 Cyclooxygenase Inhibitors Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 HIV Protease Inhibitors Phase 4,Not Applicable
19 Anesthetics Phase 4,Not Applicable
20 Hormone Antagonists Phase 4,Phase 2,Not Applicable
21 Anesthetics, Local Phase 4,Not Applicable
22 Hormones Phase 4,Phase 2,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Not Applicable
25 Antiemetics Phase 4,Not Applicable
26 Anti-Inflammatory Agents Phase 4,Phase 2,Not Applicable
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4
28 Antirheumatic Agents Phase 4,Phase 1,Phase 2
29 BB 1101 Phase 4,Not Applicable
30 Autonomic Agents Phase 4,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 4,Not Applicable
32 Epinephryl borate Phase 4
33
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
34 triamcinolone acetonide Phase 2
35 Triamcinolone diacetate Phase 2
36 Triamcinolone hexacetonide Phase 2
37 Pharmaceutical Solutions Phase 2
38 Immunosuppressive Agents Phase 2
39 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2,Phase 2
40
Oxybutynin Approved, Investigational Not Applicable 5633-20-5 4634
41
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
42
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
43
Menthol Approved 2216-51-5 16666
44
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
45
Mepivacaine Approved, Vet_approved Not Applicable 96-88-8 4062
46
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
47 Hops Approved, Nutraceutical Not Applicable
48
Vitamin C Approved, Nutraceutical Not Applicable 50-81-7 5785 54670067
49 Chlorhexidine gluconate Not Applicable
50 Adjuvants, Immunologic Not Applicable

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Anterior Cruciate Ligament (ACL) Reconstruction: Single Bundle Versus Double Bundle Unknown status NCT01025895 Phase 4
2 Evaluation of Biocleanse Allografts For ACL Reconstruction Completed NCT00187876 Phase 4
3 Liposomal Bupivacaine for Pain Control Following Anterior Cruciate Ligament Reconstruction Completed NCT02189317 Phase 4 Exparel
4 COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined Completed NCT01361789 Phase 4 parecoxib, valdecoxib, etoricoxib;Dexamethasone;parecoxib, valdecoxib, parecoxib and dexamethasone
5 Pain Relief Results After Anterior Cruciate Ligament (ACL) Reconstruction Completed NCT00022854 Phase 4
6 Simultaneous Multiple Cruciate Ligament Reconstructions Using a Single Achilles Allograft Completed NCT01440348 Phase 4
7 Local Infiltration Analgesia vs Adductor Canal Block for Analgesia After Anterior Cruciate Ligament Reconstruction Completed NCT02524652 Phase 4 Ropivacaine 0.5% 20 mLs
8 Analgesic Benefits of Genicular Nerve Blocks of the Posterior Knee for Patients Undergoing ACL Reconstruction Terminated NCT02008617 Phase 4 Bupivacaine;Preservative free normal saline
9 Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? Not yet recruiting NCT03496389 Phase 2, Phase 3 Gabapentin;Tramadol;Panadol
10 Early Treatment for Acute ACL Tear Completed NCT01692756 Phase 2 Kenalog or placebo;Kenalog then Placebo;Kenalog;Placebo
11 Comparison of Early Versus Delay Reconstruction in Anterior Cruciate Ligament Tearing Completed NCT01580722 Phase 2
12 Evaluation of Tibial and Femoral Tunnel Position After Arthroscopic Reconstruction of the Anterior Cruciate Ligament Completed NCT01267435 Phase 2
13 RCT of PEP Program to Reduce ACL Injuries in Female Collegiate Soccer Players Completed NCT00140270 Phase 2
14 Study to Prevent Cartilage Damage Following Acute Knee Injury. Completed NCT00332254 Phase 1, Phase 2 Anakinra
15 Evaluation of rGH Therapy to Prevent Muscle Atrophy in Patients With ACL Tears Recruiting NCT02420353 Phase 2 Somatropin;Placebo
16 IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions Not yet recruiting NCT02930122 Phase 2 Saline (0.9%) and anakinra (150mg);anakinra (150mg) and Saline (0.9%)
17 Can PRP Reduce Pro-Inflammatory Biomarkers Following ACL Injury Not yet recruiting NCT03389685 Phase 2
18 Bridge-Enhanced ACL Repair-Safety Study (BEAR Trial) Completed NCT02292004 Phase 1
19 Efficacy of Preoperative Re-education on Patients With an Anterior Cruciate Ligament Rupture Unknown status NCT02505659 Not Applicable
20 Retrospective CT Imaging of BioComposite Interference Screw With BTB Unknown status NCT02450292
21 Anterior Cruciate Ligament Radiology Follow-up Study Unknown status NCT02816606
22 Comparison of Remnant Preserving Versus Remnant Resecting Anterior Cruciate Ligament Reconstruction Unknown status NCT02555917 Not Applicable
23 Study of Single And Double Bundle Anterior Cruciate Ligament (ACL) Graft Cross-sectional Dimensions Unknown status NCT02834962 Not Applicable
24 The Effect of Functional Electrical Stimulation Unknown status NCT02817399 Not Applicable
25 Comparison of Femoral Tunnel and Clinical Outcome Using Two Anterior Cruciate Ligament Reconstruction Techniques Unknown status NCT02754674 Not Applicable
26 A Pilot Study to Investigate Biomarkers in Anterior Cruciate Ligament (ACL) Patients and Healthy Controls Unknown status NCT02300012 Not Applicable
27 Safety and Efficacy of the Knee-T-nol Anterior Cruciate Ligament (ACL) Prosthesis Unknown status NCT01450332 Not Applicable
28 Quadriceps Function Prior to Anterior Cruciate Ligament Reconstruction Unknown status NCT00971451 Not Applicable
29 Comparison of Dynamic Knee Stability and Functional Outcomes in Anatomical ACL Reconstruction at AM or Central Position Unknown status NCT02074917 Not Applicable
30 Proprioceptive Function, Postural Stability & Clinical Outcome After Stump Preserving Anterior Cruciate Ligament Reconstruction Surgery Unknown status NCT01348945 Not Applicable
31 Comparison of Doubled Quadrupled Versus Quadrupled Allograft Tissue Constructs for Anterior Cruciate Ligament (ACL) Reconstruction Unknown status NCT01148784 Not Applicable
32 Magnetic Resonance Imaging and Functional Performance Outcome After ACL Repair With Internal Brace Technique Completed NCT02760589
33 Characterizing Clinical and Biomechanical Contributions to Function Following ACL Reconstruction Completed NCT03132987 Not Applicable
34 Induced ACL Healing With the Ligamys Technique: a Prospective, Multicenter Observational Case Series Completed NCT02203214
35 Effect of Tunnel Placements on Clinical and MRI Findings Two Years After ACL Reconstruction With DB Technique Completed NCT02000258 Not Applicable
36 Single Bundle Anterior Cruciate Ligament Reconstruction in Active Young Men Completed NCT01533025 Not Applicable
37 Femoral Tunnel Position on Conventional MRI After Anterior Cruciate Ligament Reconstruction-Transtibial Technique Versus Transportal Technique Completed NCT01513434 Not Applicable
38 Stability of the Knee Joint After Single and Double Bundle Anterior Cruciate Ligament Reconstruction Completed NCT01391650 Not Applicable
39 The Effect of Early WBVT on Neuromuscular Control After ACLR Completed NCT01300182 Not Applicable
40 BioCleanse Tibialis Tendon Anterior Cruciate Ligament (ACL) Study Completed NCT00975845
41 Anterior Cruciate Ligament (ACL) Reconstruction- Bioabsorbable Screw Completed NCT01069588
42 Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction Completed NCT01537588 Not Applicable
43 Clinical Trial Comparing Three Anterior Cruciate Ligament Reconstructive Procedures Completed NCT00418964 Not Applicable
44 Efficacy and Tolerability of a Nutritional Supplement, Plactive Progen, in ACL Reconstruction Completed NCT03355651 Not Applicable
45 Regenexx™ SD Versus Exercise Therapy for ACL Tears Recruiting NCT01850758 Not Applicable
46 Longitudinal Assessment of Cartilage Injury and Remodeling After Anterior Cruciate Ligament Rupture and Reconstruction: Recruiting NCT03497780
47 Anterior Cruciate Ligament Rupture Recruiting NCT02740452 Not Applicable
48 Arthroscopic Primary Repair of the Anterior Cruciate Ligament (ACL) Recruiting NCT03510845 Not Applicable
49 Moderated Blood Flow Restriction After Anterior Cruciate Ligament Reconstruction Recruiting NCT02911909 Not Applicable
50 LIBRE (Ligamys, Internal Bracing, REconstruction) Study: Comparing Three Surgery Techniques After an Acute ACL Rupture. Recruiting NCT03441295 Not Applicable

Search NIH Clinical Center for Anterior Cruciate Ligament Tears

Genetic Tests for Anterior Cruciate Ligament Tears

Anatomical Context for Anterior Cruciate Ligament Tears

MalaCards organs/tissues related to Anterior Cruciate Ligament Tears:

41
Testes, Bone, Bone Marrow

Publications for Anterior Cruciate Ligament Tears

Articles related to Anterior Cruciate Ligament Tears:

(show top 50) (show all 154)
# Title Authors Year
1
Clinical Outcomes of Arthroscopic Primary Repair of Proximal Anterior Cruciate Ligament Tears Are Maintained at Midterm Follow-up. ( 29373290 )
2018
2
Validation of Noncontact Anterior Cruciate Ligament Tears Produced by a Mechanical Impact Simulator Against the Clinical Presentation of Injury. ( 29864374 )
2018
3
Video Analysis of Anterior Cruciate Ligament Tears in Professional American Football Athletes. ( 29466019 )
2018
4
Clinical diagnosis of partial or complete anterior cruciate ligament tears using patients' history elements and physical examination tests. ( 29894492 )
2018
5
Association of Compartmental Bone Bruise Distribution With Concomitant Intra-articular and Extra-articular Injuries in Acute Anterior Cruciate Ligament Tears After Noncontact Sports Trauma. ( 29780838 )
2018
6
Chinese Ethnicity Is Associated With Concomitant Cartilage Injuries in Anterior Cruciate Ligament Tears. ( 29376084 )
2018
7
Prospective comparative study of knee laxity with four different methods in anterior cruciate ligament tears. ( 29396803 )
2018
8
Presence of meniscus tear alters gene expression profile of anterior cruciate ligament tears. ( 29668032 )
2018
9
Comparison of magnetic resonance imaging for patients with acute and chronic anterior cruciate ligament tears. ( 29517656 )
2018
10
Regarding "Acute Proximal Anterior Cruciate Ligament Tears: Outcomes After Arthroscopic Suture Anchor Repair Versus Anatomic Single-Bundle Reconstruction". ( 28476365 )
2017
11
The Quandary of Treating Anterior Cruciate Ligament Tears in Children and Adolescents: Commentary on an article by Travis J. Dekker, MD, et al.: "Return to Sport After Pediatric Anterior Cruciate Ligament Reconstruction and Its Effect on Subsequent Anterior Cruciate Ligament Injury". ( 28590388 )
2017
12
Prospective Comparison between Remnant-Preserving Augmentation and Double-Bundle Reconstruction in Anterior Cruciate Ligament Tears. ( 28647932 )
2017
13
The Locations of Anterior Cruciate Ligament Tears in Pediatric and Adolescent Patients: A Magnetic Resonance Study. ( 28777283 )
2017
14
Magnetic Resonance Signal Abnormalities Within the Pericruciate Fat Pad: A Possible Secondary Sign for Acute Anterior Cruciate Ligament Tears. ( 28888741 )
2017
15
Advantages of RNA-seq compared to RNA microarrays for transcriptome profiling of anterior cruciate ligament tears. ( 28749036 )
2017
16
Incidence of Second Anterior Cruciate Ligament Tears and Identification of Associated Risk Factors From 2001 to 2010 Using a Geographic Database. ( 28840155 )
2017
17
Regarding "Acute Proximal Anterior Cruciate Ligament Tears: Outcomes After Arthroscopic Suture Anchor Repair Versus Anatomic Single-Bundle Reconstruction". ( 28372698 )
2017
18
The Location of Anterior Cruciate Ligament Tears: A Prevalence Study Using Magnetic Resonance Imaging. ( 28680889 )
2017
19
Acute non-contact anterior cruciate ligament tears are associated with relatively increased vastus medialis to semimembranosus cross-sectional area ratio: a case-control retrospective MR study. ( 28710543 )
2017
20
Incidence of Second Anterior Cruciate Ligament Tears (1990-2000) and Associated Factors in a Specific Geographic Locale. ( 28298067 )
2017
21
Arthroscopic anterior cruciate ligament repair for proximal anterior cruciate ligament tears in skeletally immature patients: Surgical technique and preliminary results. ( 27815015 )
2016
22
Usefulness of the quantitative evaluation of diffusion-weighted mri in the diagnosis of anterior cruciate ligament tears. ( 27079566 )
2016
23
Prevalence and Classification of Injuries of Anterolateral Complex in Acute Anterior Cruciate Ligament Tears. ( 27339397 )
2016
24
Proprioception in Patients With Anterior Cruciate Ligament Tears. ( 28060536 )
2016
25
Incidence of Anterior Cruciate Ligament Tears and Reconstruction: A 21-Year Population-Based Study. ( 26920430 )
2016
26
Delayed Reconstruction for Symptomatic Anterior Cruciate Ligament Tears: A population-based study: 3102 Board #167 June 3, 3: 30 PM - 5: 00 PM. ( 27361671 )
2016
27
Rehabilitation Following Anterior Cruciate Ligament Tears in Children: A Systematic Review. ( 27490007 )
2016
28
Acute Proximal Anterior Cruciate Ligament Tears: Outcomes After Arthroscopic Suture Anchor Repair Versus Anatomic Single-Bundle Reconstruction. ( 27324969 )
2016
29
Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood. ( 27214559 )
2016
30
Changes in Transcriptome-Wide Gene Expression of Anterior Cruciate Ligament Tears Based on Time From Injury. ( 27159315 )
2016
31
Arthroscopic Primary Repair of Proximal Anterior Cruciate Ligament Tears. ( 27909675 )
2016
32
Clinical outcomes and biomechanical analysis of posterolateral bundle augmentation in patients with partial anterior cruciate ligament tears. ( 26162801 )
2015
33
Sport-Specific Yearly Risk and Incidence of Anterior Cruciate Ligament Tears in High School Athletes: A Systematic Review and Meta-analysis. ( 26657853 )
2015
34
Anterior cruciate ligament tears for the primary care sports physician: what to know on the field and in the office. ( 26559706 )
2015
35
Quadriceps Strength and Endurance After Posterior Cruciate Ligament Tears Versus Matched Group With Anterior Cruciate Ligament Tears. ( 25769481 )
2015
36
Effect of Time after Anterior Cruciate Ligament Tears on Proprioception and Postural Stability. ( 26422800 )
2015
37
Body Mass Index as an Indicator of Associated Intra-articular Injuries in Patients With Anterior Cruciate Ligament Tears. ( 26688985 )
2015
38
State-of-the-art anterior cruciate ligament tears: A primer for primary care physicians. ( 25703144 )
2015
39
Anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow nucleated cells: a case series. ( 26261424 )
2015
40
Lack of Correlation between Dynamic Balance and Hamstring-to-Quadriceps Ratio in Patients with Chronic Anterior Cruciate Ligament Tears. ( 26060609 )
2015
41
Comparison of Clinical Outcome of Autograft and Allograft Reconstruction for Anterior Cruciate Ligament Tears. ( 26612290 )
2015
42
The Importance of the Intercondylar Notch in Anterior Cruciate Ligament Tears. ( 26535388 )
2015
43
Management of anterior cruciate ligament tears in skeletally immature athletes. ( 26329291 )
2015
44
Anterior cruciate ligament tears: reconstruction and rehabilitation. ( 24457384 )
2014
45
Incidence and treatment of intra-articular lesions associated with anterior cruciate ligament tears. ( 26528008 )
2014
46
Oblique coronal and oblique sagittal MRI for diagnosis of anterior cruciate ligament tears and evaluation of anterior cruciate ligament remnant tissue. ( 23707632 )
2014
47
Partial anterior cruciate ligament tears treated with intraligamentary plasma rich in growth factors. ( 25035842 )
2014
48
The incidence of trochlear dysplasia in anterior cruciate ligament tears. ( 24515227 )
2014
49
Validity of GNRB(Ar) arthrometer compared to Telosa8c in the assessment of partial anterior cruciate ligament tears. ( 23338663 )
2014
50
Cost-Effectiveness Analysis of Early Reconstruction Versus Rehabilitation and Delayed Reconstruction for Anterior Cruciate Ligament Tears. ( 24801663 )
2014

Variations for Anterior Cruciate Ligament Tears

Expression for Anterior Cruciate Ligament Tears

Search GEO for disease gene expression data for Anterior Cruciate Ligament Tears.

Pathways for Anterior Cruciate Ligament Tears

GO Terms for Anterior Cruciate Ligament Tears

Sources for Anterior Cruciate Ligament Tears

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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